TY - JOUR A1 - Achtsnicht, Stefan A1 - Tödter, Julia A1 - Niehues, Julia A1 - Telöken, Matthias A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim A1 - Schröper, Florian T1 - 3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection JF - Sensors N2 - For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated. Y1 - 2019 U6 - http://dx.doi.org/10.3390/s19010148 SN - 1424-8220 VL - 19 IS - 1 PB - MDPI CY - Basel ER - TY - BOOK A1 - Gebhardt, Andreas A1 - Kessler, Julia A1 - Thurn, Laura T1 - 3D printing : understanding additive manufacturing Y1 - 2019 SN - 978-1-56990-702-3 SN - 978-1-56990-703-0 ebook N1 - gedruckt in der Bereichsbibliothek Eupener Str. vorhanden PB - Hanser CY - München ET - 2. Auflage ER - TY - JOUR A1 - Orzada, Stephan A1 - Solbach, Klaus A1 - Gratz, Marcel A1 - Brunheim, Sascha A1 - Fiedler, Thomas M. A1 - Johst, Sören A1 - Bitz, Andreas A1 - Shooshtary, Samaneh A1 - Abuelhaija, Asjraf A1 - Voelker, Maximilian N. A1 - Rietsch, Stefan H. G. A1 - Kraff, Oliver A1 - Maderwald, Stefan A1 - Flöser, Martina A1 - Oehmingen, Mark A1 - Quick, Harald H. A1 - Ladd, Mark E. T1 - A 32-channel parallel transmit system add-on for 7T MRI JF - Plos one Y1 - 2019 U6 - http://dx.doi.org/10.1371/journal.pone.0222452 ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - A computational study of organ relocation after laparoscopic pectopexy to repair posthysterectomy vaginal vault prolapse JF - Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization Y1 - 2019 U6 - http://dx.doi.org/10.1080/21681163.2019.1670095 SN - 2168-1171 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Götten, Falk A1 - Finger, Felix A1 - Havermann, Marc A1 - Braun, Carsten A1 - Marino, Matthew A1 - Bil, Cees T1 - A highly automated method for simulating airfoil characteristics at low Reynolds number using a RANS - transition approach T2 - Deutscher Luft- und Raumfahrtkongress - DLRK 2019. Darmstadt, Germany Y1 - 2019 U6 - http://dx.doi.org/10.25967/490026 SP - 1 EP - 14 ER - TY - JOUR A1 - Dantism, Shahriar A1 - Röhlen, Desiree A1 - Wagner, Torsten A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - A LAPS-based differential sensor for parallelized metabolism monitoring of various bacteria JF - Sensors N2 - Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process. Y1 - 2019 U6 - http://dx.doi.org/10.3390/s19214692 SN - 1424-8220 VL - 19 IS - 21 PB - MDPI CY - Basel ER - TY - JOUR A1 - Leschinger, Tim A1 - Birgel, Stefan A1 - Hackl, Michael A1 - Staat, Manfred A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - A musculoskeletal shoulder simulation of moment arms and joint reaction forces after medialization of the supraspinatus footprint in rotator cuff repair JF - Computer Methods in Biomechanics and Biomedical Engineering Y1 - 2019 U6 - http://dx.doi.org/10.1080/10255842.2019.1572749 IS - Early view PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Linder, Peter A1 - Beckler, Matthias A1 - Doerr, Leo A1 - Stoelzle-Feix, Sonja A1 - Fertig, Niels A1 - Jung, Alexander A1 - Staat, Manfred A1 - Gossmann, Matthias T1 - A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions JF - Journal of Pharmacological and Toxicological Methods Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.vascn.2019.05.162 SN - 1056-8719 VL - 99 IS - Article number 106595 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Valero, Daniel A1 - Kramer, Matthias A1 - Bung, Daniel B. A1 - Chanson, Hubert T1 - A stochastic bubble generator for air-water flow research T2 - E-proceedings of the 38th IAHR World Congress, September 1-6, 2019, Panama City, Panama Y1 - 2019 U6 - http://dx.doi.org/10.3850/38WC092019-0909 SP - 5714 EP - 5721 ER - TY - CHAP A1 - Siebigteroth, Ines A1 - Kraft, Bodo A1 - Schmidts, Oliver A1 - Zündorf, Albert T1 - A Study on Improving Corpus Creation by Pair Annotation T2 - Proceedings of the Poster Session of the 2nd Conference on Language, Data and Knowledge (LDK-PS 2019) Y1 - 2019 SN - 1613-0073 SP - 40 EP - 44 ER - TY - CHAP A1 - Ferrein, Alexander A1 - Scholl, Ingrid A1 - Neumann, Tobias A1 - Krückel, Kai A1 - Schiffer, Stefan T1 - A system for continuous underground site mapping and exploration Y1 - 2019 U6 - http://dx.doi.org/10.5772/intechopen.85859 ER - TY - JOUR A1 - Ketelhut, Maike A1 - Kolditz, Melanie A1 - Göll, Fabian A1 - Braunstein, Bjoern A1 - Albracht, Kirsten A1 - Abel, Dirk T1 - Admittance control of an industrial robot during resistance training JF - IFAC-PapersOnLine N2 - Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories. KW - Assistive technology KW - Rehabilitation engineering KW - Human-Computer interaction KW - Automatic control Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.ifacol.2019.12.102 SN - 2405-8963 N1 - 14th IFAC Symposium on Analysis, Design, and Evaluation of Human Machine Systems HMS 2019 Tallinn, Estonia, 16–91 September 2019 VL - 52 IS - 19 SP - 223 EP - 228 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Gerhards, Benjamin A1 - Schleser, Markus A1 - Otten, Christian T1 - Advancements of mobile vacuum laser welding for industrial thick sheet applications T2 - Conference Proceedings 72nd IIW Annual Assembly and International Conference, 7-12 July 2019, Bratislava Y1 - 2019 SP - 1 EP - 8 ER - TY - JOUR A1 - Schael, S. A1 - Atanasyan, A. A1 - Berdugo, J. A1 - Bretz, T. A1 - Czupalla, Markus A1 - Dachwald, Bernd A1 - Doetinchem, P. von A1 - Duranti, M. A1 - Gast, H. A1 - Karpinski, W. A1 - Kirn, T. A1 - Lübelsmeyer, K. A1 - Maña, C. A1 - Marrocchesi, P.S. A1 - Mertsch, P. A1 - Moskalenko, I.V. A1 - Schervan, T. A1 - Schluse, M. A1 - Schröder, K.-U. A1 - Schultz von Dratzig, A. A1 - Senatore, C. A1 - Spies, L. A1 - Wakely, S.P. A1 - Wlochal, M. A1 - Uglietti, D. A1 - Zimmermann, J. T1 - AMS-100: The next generation magnetic spectrometer in space – An international science platform for physics and astrophysics at Lagrange point 2 JF - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment Y1 - 2019 U6 - http://dx.doi.org/10.1016/j.nima.2019.162561 SN - 0168-9002 VL - 944 IS - 162561 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Rao, Deepak A1 - Pathrose, Plato A1 - Hüning, Felix A1 - Sid, Jithin T1 - An Approach for Validating Safety of Perception Software in Autonomous Driving Systems T2 - Model-Based Safety and Assessment: 6th International Symposium, IMBSA 2019, Thessaloniki, Greece, October 16–18, 2019, Proceedings N2 - The increasing complexity of Advanced Driver Assistance Systems (ADAS) presents a challenging task to validate safe and reliable performance of these systems under varied conditions. The test and validation of ADAS/AD with real test drives, although important, involves huge costs and time. Simulation tools provide an alternative with the added advantage of reproducibility but often use ideal sensors, which do not reflect real sensor output accurately. This paper presents a new validation methodology using fault injection, as recommended by the ISO 26262 standard, to test software and system robustness. In our work, we investigated and developed a tool capable of inserting faults at different software and system levels to verify its robustness. The scope of this paper is to cover the fault injection test for the Visteon’s DriveCore™ system, a centralized domain controller for Autonomous driving which is sensor agnostic and SoC agnostic. With this new approach, the validation of safety monitoring functionality and its behavior can be tested using real-world data instead of synthetic data from simulation tools resulting in having better confidence in system performance before proceeding with in-vehicle testing. KW - Advanced driver assistance systems (ADAS/AD) KW - ISO 26262 KW - Safety-critical systems validation KW - Safety of the intended functionality (SOTIF) Y1 - 2019 SN - 978-3-030-32872-6 U6 - http://dx.doi.org/10.1007/978-3-030-32872-6_20 SP - 303 EP - 316 PB - Springer CY - Cham ER - TY - CHAP A1 - Finger, Felix A1 - Khalsa, R. A1 - Kreyer, Jörg A1 - Mayntz, Joscha A1 - Braun, Carsten A1 - Dahmann, Peter A1 - Esch, Thomas A1 - Kemper, Hans A1 - Schmitz, O. A1 - Bragard, Michael T1 - An approach to propulsion system modelling for the conceptual design of hybrid-electric general aviation aircraft T2 - Deutscher Luft- und Raumfahrtkongress 2019, 30.9.-2.10.2019, Darmstadt N2 - In this paper, an approach to propulsion system modelling for hybrid-electric general aviation aircraft is presented. Because the focus is on general aviation aircraft, only combinations of electric motors and reciprocating combustion engines are explored. Gas turbine hybrids will not be considered. The level of the component's models is appropriate for the conceptual design stage. They are simple and adaptable, so that a wide range of designs with morphologically different propulsive system architectures can be quickly compared. Modelling strategies for both mass and efficiency of each part of the propulsion system (engine, motor, battery and propeller) will be presented. Y1 - 2019 ER - TY - CHAP A1 - Alhwarin, Faraj A1 - Ferrein, Alexander A1 - Scholl, Ingrid T1 - An Efficient Hashing Algorithm for NN Problem in HD Spaces T2 - Lecture Notes in Computer Science Y1 - 2019 SN - 978-303005498-4 U6 - http://dx.doi.org/10.1007/978-3-030-05499-1_6 N1 - 7th International Conference on Pattern Recognition Applications and Methods, ICPRAM 2018; Funchal; Portugal; 16 January 2018 through 18 January 2018; Code 222779 SP - 101 EP - 115 ER - TY - JOUR A1 - Weber, Tobias A1 - Englhard, Markus A1 - Arent, Jan-Christoph A1 - Hausmann, Joachim T1 - An experimental characterization of wrinkling generated during prepreg autoclave manufacturing using caul plates JF - Journal of Composite Materials Y1 - 2019 U6 - http://dx.doi.org/10.1177/0021998319846556 SN - 1530-793X VL - 53 IS - 26-27 SP - 3757 EP - 3773 ER - TY - JOUR A1 - Scheer, Nico A1 - Henderson, Colin James A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Mclaren, Aileen W. A1 - MacLeod, Alastair Kenneth A1 - Lin, De A1 - Wright, Jayne A1 - Stanley, Lesley A1 - Wolf, C. Roland T1 - An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials JF - Drug Metabolism and Disposition Y1 - 2019 U6 - http://dx.doi.org/10.1124/dmd.119.086397 IS - Early view ER - TY - CHAP A1 - Alhwarin, Faraj A1 - Schiffer, Stefan A1 - Ferrein, Alexander A1 - Scholl, Ingrid T1 - An Optimized Method for 3D Body Scanning Applications Based on KinectFusion T2 - Communications in Computer and Information Science Y1 - 2019 U6 - http://dx.doi.org/10.1007/978-3-030-29196-9_6 SN - 1865-0929 N1 - 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018; Funchal; Portugal; 19 January 2018 through 21 January 2018 VL - 1024 SP - 100 EP - 113 PB - Springer ER -