TY - JOUR A1 - Wollbrink, Moritz A1 - Maslo, Semir A1 - Zimmer, Daniel A1 - Abbas, Karim A1 - Arntz, Kristian A1 - Bergs, Thomas T1 - Clamping and substrate plate system for continuous additive build-up and post-processing of metal parts JF - Procedia CIRP N2 - The manufacturing share of laser powder bed fusion (L-PBF) increases in industrial application, but still many process steps are manually operated. Additionally, it is not possible to achieve tight dimensional tolerances or low surfaces roughness. Hence, a process chain has to be set up to combine additive manufacturing (AM) with further machining technologies. To achieve a continuous workpiece flow as basis for further industrialization of L-PBF, the paper presents a novel substrate system and its application on L-PBF machines and post-processing. The substrate system consists of a zero-point clamping system and a matrix-like interface of contact pins to be substantially connected to the workpiece within the L-PBF process. Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.procir.2020.04.015 SN - 2212-8271 VL - 93 SP - 108 EP - 113 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Stulpe, Werner A1 - Busch, P. A1 - Hellwig, K.-E. T1 - Classical Representations of Finite-Dimensional Quantum Mechanics. Busch, P.; Hellwig, K.-E.; Stulpe, W. JF - International Journal of Theoretical Physics. 32 (1993), H. 3 Y1 - 1993 SN - 1572-9575 SP - 399 EP - 405 ER - TY - BOOK A1 - Stulpe, Werner T1 - Classical Representations of Quantum Mechanics Related to Statistically Complete Observables Y1 - 1997 SN - 3-89685-438-0 N1 - Zugl. Berlin, Techn. Univ., Habil.-Schr. 1997 PB - Wissenschaft und Technik Verl. CY - Berlin ER - TY - JOUR A1 - Grotendorst, Johannes A1 - Eitrich, T. A1 - Kless, A. A1 - Druska, C. T1 - Classification of Highly Unbalanced CYP450 Data of Drugs Using Cost Sensitive Machine Learning Techniques / Eitrich, T. ; Kless, A. ; Druska, C. ; Meyer, W. ; Grotendorst J. JF - Journal of Chemical Information and Modeling. 47 (2007), H. 1 Y1 - 2007 SN - 1549-9596 SP - 92 EP - 103 ER - TY - CHAP A1 - Dachwald, Bernd A1 - Ulamec, Stephan A1 - Biele, Jens T1 - Clean in situ subsurface exploration of icy environments in the solar system T2 - Habitability of other planets and satellites. - (Cellular origin, life in extreme habitats and astrobiology ; 28) N2 - "To assess the habitability of the icy environments in the solar system, for example, on Mars, Europa, and Enceladus, the scientific analysis of material embedded in or underneath their ice layers is very important. We consider self-steering robotic ice melting probes to be the best method to cleanly access these environments, that is, in compliance with planetary protection standards. The required technologies are currently developed and tested." Y1 - 2013 SN - 978-94-007-6545-0 (Druckausgabe) SN - 978-94-007-6546-7 (E-Book) SP - 367 EP - 397 PB - Springer CY - Dordrecht ER - TY - CHAP A1 - Blanke, Tobias A1 - Dring, Bernd A1 - Vontein, Marius A1 - Kuhnhenne, Markus T1 - Climate Change Mitigation Potentials of Vertical Building Integrated Photovoltaic T2 - 8th International Workshop on Integration of Solar Power into Power Systems : 16-17 October 2018, Stockholm, Sweden Y1 - 2018 SP - 1 EP - 7 ER - TY - JOUR A1 - Behnam, S. A1 - Becker, A. A1 - Weber, Hans-Joachim T1 - Clinical benefit and cost-efficiency of minimized perfusion circuits for extracorporeal circulation during cardiac surgery JF - Zeitschrift für Herz-, Thorax- und Gefäßchirurgie Y1 - 2011 SN - 0930-9225 N1 - Abstracts der 40. Internationalen Jahrestagung der DGfK und 3. Fokustagung Herz Kardiotechnik – Intensivmedizin – Herzchirurgie – Rhythmustherapie 11. bis 13. November 2011 in Weimar VL - 25 IS - 5 SP - 305 EP - 306 PB - Springer CY - Berlin ER - TY - JOUR A1 - Zhang, Jin A1 - Heimbach, Tycho A1 - Scheer, Nico A1 - Barve, Avantika A1 - Li, Wenkui A1 - Lin, Wen A1 - He, Handan T1 - Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4–Humanized Mouse Studies With PBPK Modeling JF - Journal of Pharmaceutical Sciences N2 - NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir. Y1 - 2016 U6 - http://dx.doi.org/doi.org/10.1016/j.xphs.2016.01.021 SN - 0022-3549 VL - Volume 105 IS - Issue 4 SP - 1398 EP - 1404 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Meyer, Max-Arno A1 - Granrath, Christian A1 - Feyerl, Günter A1 - Richenhagen, Johannes A1 - Kaths, Jakob A1 - Andert, Jakob T1 - Closed-loop platoon simulation with cooperative intelligent transportation systems based on vehicle-to-X communication JF - Simulation Modelling Practice and Theory Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.simpat.2020.102173 SN - 1569-190X VL - 106 IS - Art. 102173 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Siepmann, Thomas A1 - Rupietta, D. T1 - Closer to the customer with computerized product support JF - Technische Mitteilungen Krupp (1993) Y1 - 1993 CY - Essen ER - TY - JOUR A1 - Engel, Mareike A1 - Gemünde, Andre A1 - Holtmann, Dirk A1 - Müller-Renno, Christine A1 - Ziegler, Christiane A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Clostridium acetobutylicum’s connecting world: cell appendage formation in bioelectrochemical systems JF - ChemElectroChem Y1 - 2019 U6 - http://dx.doi.org/10.1002/celc.201901656 SN - 2196-0216 IS - Accepted Article PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Valero, D. A1 - Bung, Daniel B. A1 - Crookston, B. M. T1 - Closure to “Energy Dissipation of a Type III Basin under Design and Adverse Conditions for Stepped and Smooth Spillways” JF - Journal of Hydraulic Engineering Y1 - 2019 U6 - http://dx.doi.org/10.1061/(ASCE)HY.1943-7900.0001669 VL - 146 IS - 2 PB - ASCE CY - Reston, Va. ER - TY - JOUR A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Nishikawa, K. A1 - Artmann, Gerhard T1 - Cluster air-ion effects on bacteria and moulds JF - Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2 Y1 - 2004 SN - 0932-4666 SP - 1040 EP - 1041 ER - TY - JOUR A1 - Krome, Cornelia A1 - Höft, Jan A1 - Sander, Volker T1 - Clustering time series applied to energy markets JF - Energy Informatics Y1 - 2019 U6 - http://dx.doi.org/10.1186/s42162-019-0076-0 SN - 2520-8942 VL - 2 IS - Article numer 17 SP - 1 EP - 20 PB - Springer CY - Berlin ER - TY - CHAP A1 - Hammer, Andreas A1 - Vieth, Matthias A1 - Maier, Frank T1 - Co-Plot as a new multivariate analysis method for operations management research? T2 - Papers of the 12th International EurOMA Conference on Operational and Global Competitiveness, Budapest, Hungary, June 19-22, 2005 / Editor: Krisztina Demeter Y1 - 2005 SN - 963-218-455-6 SP - 1007 EP - 1016 ER - TY - CHAP A1 - Dey, Thomas A1 - Elsen, Ingo A1 - Ferrein, Alexander A1 - Frauenrath, Tobias A1 - Reke, Michael A1 - Schiffer, Stefan ED - Makedon, Fillia T1 - CO2 Meter: a do-it-yourself carbon dioxide measuring device for the classroom T2 - PETRA 2021: The 14th PErvasive Technologies Related to Assistive Environments Conference N2 - In this paper we report on CO2 Meter, a do-it-yourself carbon dioxide measuring device for the classroom. Part of the current measures for dealing with the SARS-CoV-2 pandemic is proper ventilation in indoor settings. This is especially important in schools with students coming back to the classroom even with high incidents rates. Static ventilation patterns do not consider the individual situation for a particular class. Influencing factors like the type of activity, the physical structure or the room occupancy are not incorporated. Also, existing devices are rather expensive and often provide only limited information and only locally without any networking. This leaves the potential of analysing the situation across different settings untapped. Carbon dioxide level can be used as an indicator of air quality, in general, and of aerosol load in particular. Since, according to the latest findings, SARS-CoV-2 can be transmitted primarily in the form of aerosols, carbon dioxide may be used as a proxy for the risk of a virus infection. Hence, schools could improve the indoor air quality and potentially reduce the infection risk if they actually had measuring devices available in the classroom. Our device supports schools in ventilation and it allows for collecting data over the Internet to enable a detailed data analysis and model generation. First deployments in schools at different levels were received very positively. A pilot installation with a larger data collection and analysis is underway. KW - embedded hardware KW - sensor networks KW - information systems KW - education KW - do-it-yourself Y1 - 2021 SN - 9781450387927 U6 - http://dx.doi.org/10.1145/3453892.3462697 N1 - PETRA '21: The 14th PErvasive Technologies Related to Assistive Environments Conference Corfu Greece 29 June 2021- 2 July 2021 SP - 292 EP - 299 PB - Association for Computing Machinery CY - New York ER - TY - PAT A1 - Lauth, Jakob A1 - Hoelderich, Wolfgang A1 - Harth, Klaus A1 - Hibst, Hartmuth T1 - Coated catalysts : United States Patent ; patent number 5,559,065 ; date of patent: Sep. 24, 1996 / assignee: BASF Aktiengesellschaft Y1 - 1996 N1 - Barcode: US005559065A ; Volltext über Datenbank: http://www.google.com/patents PB - [United States Trademark and Patent Office] CY - [Alexandria, VA] ER - TY - JOUR A1 - Biselli, Manfred A1 - Schröder, B. A1 - Herfurth, C. A1 - Schmoll, H.-J. T1 - Cocultivation of hematopoietic cells in a fluidized bed reactor / Schröder, B. ; Herfurth, C. ; Biselli, M. ; Schmoll, H.-J. ; Link, H. ; Ebell, W. ; Wandrey, C. JF - Animal cell technology : basic & applied aspects : proceedings of the Eighth Annual Meeting of the Japanese Association for Animal Cell Technology, Iizuka, Fukuoka, Japan, November 6-10, 1995 / edited by K. Funatsu, Y. Shirai, and T. Matsushita Y1 - 1997 SN - 0-7923-4486-3 N1 - Japanese Association for Animal Cell Technology. ; Meeting ; <8 ; 1995 : ; Iizuka-shi, Japan> SP - 137 EP - 141 PB - Kluwer Acad. Press CY - Boston ER - TY - JOUR A1 - Angermann, Susanne A1 - Günthner, Roman A1 - Hanssen, Henner A1 - Lorenz, Georg A1 - Braunisch, Matthias C. A1 - Steubl, Dominik A1 - Matschkal, Julia A1 - Kemmner, Stephan A1 - Hausinger, Renate A1 - Block, Zenonas A1 - Haller, Bernhard A1 - Heemann, Uwe A1 - Kotliar, Konstantin A1 - Grimmer, Timo A1 - Schmaderer, Christoph T1 - Cognitive impairment and microvascular function in end-stage renal disease JF - International Journal of Methods in Psychiatric Research (MPR) N2 - Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention. KW - cerebral small vessel disease KW - cognitive impairment KW - dialysis KW - retinal vessels Y1 - 2022 U6 - http://dx.doi.org/10.1002/mpr.1909 SN - 1049-8931 (Print) SN - 1557-0657 (Online) VL - 31 IS - 2 SP - 1 EP - 10 PB - Wiley ER - TY - CHAP A1 - Steinbauer, Gerald A1 - Ferrein, Alexander T1 - CogRob 2018 : Cognitive Robotics Workshop. Proceedings of the 11th Cognitive Robotics Workshop 2018 co-located with 16th International Conference on Principles of Knowledge Representation and Reasoning (KR 2018). Tempe, AZ, USA, October 27th, 2018. T2 - CEUR workshop proceedings Y1 - 2019 SN - 1613-0073 N1 - edited by Gerald Steinbauer, Alexander Ferrein IS - Vol-2325 ER -