TY - JOUR A1 - Fateri, Miranda A1 - Gebhardt, Andreas A1 - Thümmler, Stefan A1 - Thurn, Laura T1 - Experimental investigation on selective laser melting of glass JF - Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014 Y1 - 2014 U6 - https://doi.org/10.1016/j.phpro.2014.08.118 SN - 1875-3892 (E-Journal); 1875-3884 (Print) VL - 56 (2014) SP - 357 EP - 364 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Altherr, Lena A1 - Ederer, Thorsten A1 - Lorenz, Ulf A1 - Pelz, Peter F. A1 - Pöttgen, Philipp ED - Lübbecke, Marco ED - Koster, Arie ED - Letmathe, Peter ED - Madlener, Reihard ED - Peis, Britta ED - Walther, Grit T1 - Experimental validation of an enhanced system synthesis approach JF - Operations Research Proceedings 2014 N2 - Planning the layout and operation of a technical system is a common task for an engineer. Typically, the workflow is divided into consecutive stages: First, the engineer designs the layout of the system, with the help of his experience or of heuristic methods. Secondly, he finds a control strategy which is often optimized by simulation. This usually results in a good operating of an unquestioned sys- tem topology. In contrast, we apply Operations Research (OR) methods to find a cost-optimal solution for both stages simultaneously via mixed integer program- ming (MILP). Technical Operations Research (TOR) allows one to find a provable global optimal solution within the model formulation. However, the modeling error due to the abstraction of physical reality remains unknown. We address this ubiq- uitous problem of OR methods by comparing our computational results with mea- surements in a test rig. For a practical test case we compute a topology and control strategy via MILP and verify that the objectives are met up to a deviation of 8.7%. Y1 - 2014 SN - 978-3-319-28695-2 U6 - https://doi.org/10.1007/978-3-319-28697-6_1 PB - Springer CY - Basel ER - TY - JOUR A1 - Kroll-Ludwigs, Kathrin A1 - Kaesling, Katharina T1 - Family Law and Culture in Europe: Developments, Challenges and Opportunities – Konferenz der Commission on European Family Law vom 29.-31. August 2013, Bonn JF - Zeitschrift für Europäisches Privatrecht (ZEuP) N2 - Vor dem Hintergrund zunehmender gesellschaftlicher Veränderungen bei den Lebens- und Familienformen hat es sich die Commission on European Family Law (CEFL) seit 2001 zum Ziel gesetzt, unverbindliche Regelungsvorschläge für ein europaweit einheitliches Familienrecht zu schaffen. Die Vorstellung und Diskussion dieser auf rechtsvergleichender Basis erstellten Principles erfolgt auf den regelmäßig veranstalteten Tagungen der CEFL. Die nunmehr fünfte Konferenz zum Thema „Family Law and Culture in Europe – Developments, Challenges and Opportunities“ fand erstmals in Deutschland statt. Ausgerichtet wurde die Veranstaltung, zu der ca. 200 Teilnehmerinnen und Teilnehmern aus Wissenschaft und Praxis aus insgesamt 33 Ländern angereist waren, von Nina Dethloff (Direktorin des Instituts für Deutsches, Europäisches und Internationales Familienrecht an der Universität Bonn), Katharina Boele-Woelki (Direktorin des Utrecht Centre for European Research into Family Law und Preisträgerin des Anneliese Maier-Forschungspreises der Alexander von Humboldt-Stiftung) und Werner Gephart (Direktor des Käte Hamburger Kollegs „Recht als Kultur“). Y1 - 2014 SN - 0943-3929 IS - 3 SP - 673 EP - 676 PB - Beck CY - München ER - TY - JOUR A1 - Maas, Marnix C. A1 - Vos, Eline K. A1 - Lagemaat, Miriam W. A1 - Bitz, Andreas A1 - Orzada, Stephan A1 - Kobus, Thiele A1 - Kraff, Oliver A1 - Maderwald, Stefan A1 - Ladd, Mark E. A1 - Scheenen, Tom W. J. T1 - Feasibility of T₂-weighted turbo spin echo imaging of the human prostate at 7 tesla JF - Magnetic Resonance in Medicine N2 - Purpose To demonstrate that high quality T₂-weighted (T2w) turbo spin-echo (TSE) imaging of the complete prostate can be achieved routinely and within safety limits at 7 T, using an external transceive body array coil only. Methods Nine healthy volunteers and 12 prostate cancer patients were scanned on a 7 T whole-body system. Preparation consisted of B₀ and radiofrequency shimming and localized flip angle calibration. T₁ and T₂ relaxation times were measured and used to define the T2w-TSE protocol. T2w imaging was performed using a TSE sequence (pulse repetition time/echo time 3000–3640/71 ms) with prolonged excitation and refocusing pulses to reduce specific absorption rate. Results High quality T2w TSE imaging was performed in less than 2 min in all subjects. Tumors of patients with gold-standard tumor localization (MR-guided biopsy or prostatectomy) were well visualized on 7 T imaging (n = 3). The number of consecutive slices achievable within a 10-g averaged specific absorption rate limit of 10 W/kg was ≥28 in all subjects, sufficient for full prostate coverage with 3-mm slices in at least one direction. Conclusion High quality T2w TSE prostate imaging can be performed routinely and within specific absorption rate limits at 7 T with an external transceive body array. Y1 - 2014 U6 - https://doi.org/10.1002/mrm.24818 SN - 1522-2594 VL - 71 IS - 5 SP - 1711 EP - 1719 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wollert, Jörg T1 - Feldbustechnologie JF - Factory : der Durchblick in der Technik Y1 - 2014 SP - Publ. online PB - WEKA-Industriemedien CY - Wien ER - TY - JOUR A1 - Pham, Phu Tinh A1 - Staat, Manfred T1 - FEM-based shakedown analysis of hardening structures JF - Asia Pacific journal on computational engineering N2 - This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature. Y1 - 2014 U6 - https://doi.org/10.1186/2196-1166-1-4 SN - 2196-1166 (E-Journal) IS - 1 SP - Article No. 4 PB - SpringerOpen CY - Berlin ER - TY - CHAP A1 - Oberländer, Jan A1 - Kirchner, Patrick A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Flexible polyimide-based calorimetric gas sensors for monitoring hy-drogen peroxide in sterilisation processes of aseptic filling machines T2 - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250) Y1 - 2014 SN - 978-3-8007-3622-5 SP - 1 EP - 4 PB - VDE-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Stulpe, Werner T1 - From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations JF - Journal of Mathematical Physics N2 - The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered. Y1 - 2014 U6 - https://doi.org/10.1063/1.4861939 SN - 222-488 N1 - bereits unter gleichem Titel aufgenommen bei arxiv : http://arxiv.org/pdf/1307.2314.pdf VL - 55 IS - 1 PB - AIP Publishing CY - College Park, Md. ER - TY - JOUR A1 - Huber, M. A1 - Streblow, R. A1 - Müller, D. A1 - Lange, S. A1 - Joneleit, R. A1 - Sefker, T. A1 - Rau, Sebastian A1 - Wollert, Jörg T1 - Funksignalübertragung in Luftleitungen JF - HLH : Lüftung, Klima, Heizung, Sanitär, Gebäudetechnik Y1 - 2014 SN - 1436-5103 VL - Bd. 65 IS - H. 7/8 SP - 36 EP - 40 ER - TY - JOUR A1 - Wilke, Thomas T1 - Gebaute Geschichte in Turin JF - Kunsttexte.de N2 - Städte sind Stein gewordene Geschichte. Ihre realisierte Form ermöglicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der führenden Barockmetropolen Europas beeinflusste. Y1 - 2014 U6 - https://doi.org/10.18452/7197 SN - 1618-8101 VL - 2014 IS - 1 PB - Humboldt-Universität zu Berlin CY - Berlin ER - TY - CHAP A1 - Laack, Walter van T1 - Gefahren heutiger neurologischer Schlussfolgerungen für ethische Verantwortung T2 - Ethik und Moral in Staat, Wirtschaft und Gesellschaft : 5. Rotary-Tag, 14.-15.2.2014, Kleve Y1 - 2014 SN - 978-3-944011-21-9 SP - 98 EP - 114 PB - Edition Virgines CY - Lingen ER - TY - JOUR A1 - Thomas, Axel T1 - Generation Y JF - P.T. : Magazin für Wirtschaft und Gesellschaft Y1 - 2014 SN - 1860-501X VL - 10 IS - 3 SP - 6 EP - 9 PB - OPS Netzwerk CY - Leipzig ER - TY - JOUR A1 - Scheer, Nico A1 - Wolf, C. Roland T1 - Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications JF - Xenobiotica N2 - 1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug–drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug–drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed. KW - transporters KW - human metabolites KW - drug metabolising enzymes KW - drug–drug interactions KW - bioavailability Y1 - 2014 U6 - https://doi.org/10.3109/00498254.2013.815831 SN - 1366-5928 VL - 44 IS - 2 SP - 96 EP - 108 PB - Taylor & Francis CY - Abingdon ER - TY - CHAP A1 - Burger, Ulrich A1 - Kirsch, Ansgar A1 - Marcher, Thomas A1 - Höser, Sebastian T1 - Geologisch-geotechnischer Planungsprozess von Tunnelbauten mit Schwerpunkt tiefliegender Tunnel T2 - Beton-Kalender ; Bd. 103: Unterirdisches Bauen, Grundbau, Eurocode 7 Y1 - 2014 SN - 978-3-433-03051-6 ; 978-3-433-60335-2 ; 978-3-433-60508-0 ; 3-433-60508-4 SP - 37 EP - 62 PB - Ernst CY - Berlin ER - TY - CHAP A1 - Kirsch, Ansgar A1 - Felber, W. A1 - Marcher, Thomas A1 - Fuchs, W. T1 - Geotechnical challenges during design and construction of a ski resort in Azerbaijan T2 - Geotechnics of roads and railways : proceedings of the 15th Danube - European Conference on Geotechnical Engineering : 9-11 September 2014, Vienna, Austria Y1 - 2014 SN - 978‐3‐902593‐01‐6 SP - 757 EP - 762 PB - ÖIAV - Österreichischer Ingenieur- und Architekten-Verein CY - Wien ER - TY - CHAP A1 - Borchert, Jörg A1 - Bremen, Frank T1 - Geschäfts- und Organisationsmodelle für ein Strom- und Gas-Portfoliomanagement T2 - Optimierte Strom- und Gasbeschaffung in der Energiewirtschaftsbranche Y1 - 2014 SN - 978-3-9813142-9-8 SP - 11 EP - 28 PB - KS-Energy-Verl. CY - Berlin ER - TY - JOUR A1 - Olbertz, Klaus T1 - Gestaltung des Anstellungsvertrags - Der Compliance-Beauftragte JF - Arbeit und Arbeitsrecht : AuA N2 - Ein Compliance-Beauftragter soll dafür Sorge tragen, dass aus dem Unternehmen heraus keine Rechtsverletzungen begangen werden. Aber welche rechtlichen Notwendigkeiten und Möglichkeiten resultieren daraus für die Gestaltung des Anstellungsvertrags? Y1 - 2014 SN - 0323-4568 IS - 7 SP - 400 EP - 403 PB - Huss Medien CY - Berlin ER - TY - CHAP A1 - Rosin, Julia A1 - Henneböhl, Benedickt A1 - Butenweg, Christoph T1 - Global buckling analysis of cylindrical liquid storage tanks under earthquake loading T2 - 2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6 Y1 - 2014 SN - 978-1-5108-1021-1 SP - 5270 EP - 5281 PB - Curran Associates, Inc. CY - Red Hook, NY ER - TY - CHAP A1 - Dachwald, Bernd A1 - Boehnhardt, Herrmann A1 - Broj, Ulrich A1 - Geppert, Ulrich R. M. E. A1 - Grundmann, Jan-Thimo A1 - Seboldt, Wolfgang A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Johnson, Les A1 - Kührt, Ekkehard A1 - Mottola, Stefano A1 - Macdonald, Malcolm A1 - McInnes, Colin R. A1 - Vasile, Massimiliano A1 - Reinhard, Ruedeger T1 - Gossamer roadmap technology reference study for a multiple NEO Rendezvous Mission T2 - Advances in solar sailing N2 - A technology reference study for a multiple near-Earth object (NEO) rendezvous mission with solar sailcraft is currently carried out by the authors of this paper. The investigated mission builds on previous concepts, but adopts a strong micro-spacecraft philosophy based on the DLR/ESA Gossamer technology. The main scientific objective of the mission is to explore the diversity of NEOs. After direct interplanetary insertion, the solar sailcraft should—within less than 10 years—rendezvous three NEOs that are not only scientifically interesting, but also from the point of human spaceight and planetary defense. In this paper, the objectives of the study are outlined and a preliminary potential mission profile is presented. Y1 - 2014 SN - 978-3-642-34906-5 (Print) ; 978-3-642-34907-2 (E-Book) SP - 211 EP - 226 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - Macdonald, Malcolm A1 - McGrath, C. A1 - Appourchaux, T. A1 - Dachwald, Bernd A1 - Finsterle, W. A1 - Gizon, L. A1 - Liewer, P. C. A1 - McInnes, Colin R. A1 - Mengali, G. A1 - Seboldt, Wolfgang A1 - Sekii, T. A1 - Solanki, S. K. A1 - Velli, M. A1 - Wimmer-Schweingruber, R. F. A1 - Spietz, Peter A1 - Reinhard, Ruedeger ED - Macdonald, Malcolm T1 - Gossamer roadmap technology reference study for a solar polar mission T2 - Advances in solar sailing N2 - A technology reference study for a solar polar mission is presented. The study uses novel analytical methods to quantify the mission design space including the required sail performance to achieve a given solar polar observation angle within a given timeframe and thus to derive mass allocations for the remaining spacecraft sub-systems, that is excluding the solar sail sub-system. A parametric, bottom-up, system mass budget analysis is then used to establish the required sail technology to deliver a range of science payloads, and to establish where such payloads can be delivered to within a given timeframe. It is found that a solar polar mission requires a solar sail of side-length 100–125 m to deliver a ‘sufficient value’ minimum science payload, and that a 2.5 μm sail film substrate is typically required, however the design is much less sensitive to the boom specific mass. Y1 - 2014 SN - 978-3-642-34906-5 U6 - https://doi.org/10.1007/978-3-642-34907-2_17 SP - 243 EP - 257 PB - Springer CY - Berlin, Heidelberg ER -