TY  - CHAP
A1  - Altherr, Lena
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
T1  - Optimal design of resilient technical systems on the example of water supply systems
T2  - Mastering Uncertainty in Mechanical Engineering
Y1  - 2021
SN  - 978-3-030-78356-3
N1  - Unterkapitel des Kapitels "Strategies for Mastering Uncertainty"
SP  - 429
EP  - 433
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Schoutetens, Frederic
A1  - Dachwald, Bernd
A1  - Heiligers, Jeannette
T1  - Optimisation of photon-sail trajectories in the alpha-centauri system using evolutionary neurocontrol
T2  - 8th ICATT 2021
N2  - With the increased interest for interstellar exploration after the discovery of exoplanets and the proposal by Breakthrough Starshot, this paper investigates the optimisation of photon-sail trajectories in Alpha Centauri. The prime objective is to find the optimal steering strategy for a photonic sail to get captured around one of the stars after a minimum-time transfer from Earth. By extending the idea of the Breakthrough Starshot project with a deceleration phase upon arrival, the mission’s scientific yield will be increased. As a secondary objective, transfer trajectories between the stars and orbit-raising manoeuvres to explore the habitable zones of the stars are investigated. All trajectories are optimised for minimum time of flight using the trajectory optimisation software InTrance. Depending on the sail technology, interstellar travel times of 77.6-18,790 years can be achieved, which presents an average improvement of 30% with respect to previous work. Still, significant technological development is required to reach and be captured in the Alpha-Centauri system in less than a century. Therefore, a fly-through mission arguably remains the only option for a first exploratory mission to Alpha Centauri, but the enticing results obtained in this work provide perspective for future long-residence missions to our closest neighbouring star system.
Y1  - 2021
N1  - 8th ICATT (International Conference on Astrodynamics Tools and Techniques), 23 - 25 June 2021, Virtual
SP  - 1
EP  - 15
ER  - 
TY  - JOUR
A1  - Hugenroth, Kristin
A1  - Borchardt, Ralf
A1  - Ritter, Philine
A1  - Groß‑Hardt, Sascha
A1  - Meyns, Bart
A1  - Verbelen, Tom
A1  - Steinseifer, Ulrich
A1  - Kaufmann, Tim A. S.
A1  - Engelmann, Ulrich M.
T1  - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input
JF  - Scientific Reports
N2  - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.
Y1  - 2021
U6  - https://doi.org/10.1038/s41598-021-96397-2
SN  - 2045-2322
VL  - 11
IS  - Art. No. 16800
SP  - 1
EP  - 12
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Seefeldt, Patric
A1  - Grundmann, Jan Thimo
A1  - Jahnke, Rico
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Sznajder, Maciej
A1  - Tóth, Norbert
A1  - Ceriotti, Matteo
A1  - Dachwald, Bernd
A1  - Macdonald, Malcolm
A1  - McInnes, Colin
A1  - Seboldt, Wolfgang
A1  - Quantius, Dominik
A1  - Bauer, Waldemar
A1  - Wiedemann, Carsten
A1  - Grimm, Christian D.
A1  - Hercik, David
A1  - Ho, Tra-Mi
A1  - Lange, Caroline
A1  - Schmitz, Nicole
T1  - Paths not taken – The Gossamer roadmap’s other options
JF  - Advances in Space Research
KW  - Solar sail
KW  - Small spacecraft
KW  - DLR-ESTEC GOSSAMER roadmap for solar sailing
KW  - GOSSAMER-1
Y1  - 2021
U6  - https://doi.org/10.1016/j.asr.2021.01.044
SN  - 0273-1177
VL  - 67
IS  - 9
SP  - 2912
EP  - 2956
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Valero, Daniel
A1  - Schalko, Isabella
A1  - Friedrich, Heide
A1  - Abad, Jorge D.
A1  - Bung, Daniel Bernhard
A1  - Donchyts, Gennadii
A1  - Felder, Stefan
A1  - Ferreira, Rui M. L.
A1  - Hohermuth, Benjamin
A1  - Kramer, Matthias
A1  - Li, Danxun
A1  - Mendes, Luis
A1  - Moreno-Rodenas, Antonio
A1  - Nones, Michael
A1  - Paron, Paolo
A1  - Ruiz-Villanueva, Virginia
A1  - Wang, Ruo-Qian
A1  - Franca, Mario J.
T1  - Pathways towards democratization of hydro-environment observations and data
JF  - Iahr White Paper Series
Y1  - 2021
IS  - 1
SP  - 1
EP  - 9
PB  - International Association for Hydro-Environment Engineering and Research (IAHR)
ER  - 
TY  - JOUR
A1  - Fiedler, Thomas M.
A1  - Orzada, Stephan
A1  - Flöser, Martina
A1  - Rietsch, Stefan H. G.
A1  - Quick, Harald H.
A1  - Ladd, Mark E.
A1  - Bitz, Andreas
T1  - Performance analysis of integrated RF microstrip transmit antenna arrays with high channel count for body imaging at 7 T
JF  - NMR in Biomedicine
N2  - The aim of the current study was to investigate the performance of integrated RF
transmit arrays with high channel count consisting of meander microstrip antennas
for body imaging at 7 T and to optimize the position and number of transmit ele-
ments. RF simulations using multiring antenna arrays placed behind the bore liner
were performed for realistic exposure conditions for body imaging. Simulations were
performed for arrays with as few as eight elements and for arrays with high channel
counts of up to 48 elements. The B1+ field was evaluated regarding the degrees of
freedom for RF shimming in the abdomen. Worst-case specific absorption rate
(SARwc ), SAR overestimation in the matrix compression, the number of virtual obser-
vation points (VOPs) and SAR efficiency were evaluated. Constrained RF shimming
was performed in differently oriented regions of interest in the body, and the devia-
tion from a target B1+ field was evaluated. Results show that integrated multiring
arrays are able to generate homogeneous B1+ field distributions for large FOVs, espe-
cially for coronal/sagittal slices, and thus enable body imaging at 7 T with a clinical
workflow; however, a low duty cycle or a high SAR is required to achieve homoge-
neous B1+ distributions and to exploit the full potential. In conclusion, integrated
arrays allow for high element counts that have high degrees of freedom for the pulse
optimization but also produce high SARwc , which reduces the SAR accuracy in the
VOP compression for low-SAR protocols, leading to a potential reduction in array
performance. Smaller SAR overestimations can increase SAR accuracy, but lead to a
high number of VOPs, which increases the computational cost for VOP evaluation
and makes online SAR monitoring or pulse optimization challenging. Arrays with
interleaved rings showed the best results in the study.
KW  - body imaging at UHF MRI
KW  - integrated transmit coil arrays
KW  - VOP compression
Y1  - 2021
U6  - https://doi.org/10.1002/nbm.4515
SN  - 0952-3480 (ISSN)
SN  - 1099-1492 (eISSN)
VL  - 34
IS  - 7
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Braun, Sebastian
A1  - Cheng, Chi-Tsun
A1  - Dowey, Steve
A1  - Wollert, Jörg
T1  - Performance evaluation of skill-based order-assignment in production environments with multi-agent systems
JF  - IEEE Journal of Emerging and Selected Topics in Industrial Electronics
N2  - The fourth industrial revolution introduces disruptive technologies to production environments. One of these technologies are multi-agent systems (MASs), where agents virtualize machines. However, the agent's actual performances in production environments can hardly be estimated as most research has been focusing on isolated projects and specific scenarios. We address this gap by implementing a highly connected and configurable reference model with quantifiable key performance indicators (KPIs) for production scheduling and routing in single-piece workflows. Furthermore, we propose an algorithm to optimize the search of extrema in highly connected distributed systems. The benefits, limits, and drawbacks of MASs and their performances are evaluated extensively by event-based simulations against the introduced model, which acts as a benchmark. Even though the performance of the proposed MAS is, on average, slightly lower than the reference system, the increased flexibility allows it to find new solutions and deliver improved factory-planning outcomes. Our MAS shows an emerging behavior by using flexible production techniques to correct errors and compensate for bottlenecks. This increased flexibility offers substantial improvement potential. The general model in this paper allows the transfer of the results to estimate real systems or other models.
KW  - cyber-physical production systems
KW  - event-based simulation
KW  - multi-agent systems
KW  - digital factory
KW  - industrial agents
Y1  - 2021
U6  - https://doi.org/10.1109/JESTIE.2021.3108524
SN  - 2687-9735
IS  - Early Access
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Nagamine Komesu, Cindy A.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment
JF  - Electrochemical Science Advances
N2  - Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.
KW  - enzymatic biosensor
KW  - penicillin
KW  - penicillinase
KW  - photoelectrochemistry
KW  - titanium dioxide photoanode
Y1  - 2021
U6  - https://doi.org/10.1002/elsa.202100131
SN  - 2698-5977
N1  - Corresponding author: Michael J. Schöning
VL  - 2
IS  - 4
SP  - 1
EP  - 5
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Heiligers, Jeannette
A1  - Schoutetens, Frederic
A1  - Dachwald, Bernd
T1  - Photon-sail equilibria in the alpha centauri system
JF  - Journal of Guidance, Control, and Dynamics
Y1  - 2021
U6  - https://doi.org/10.2514/1.G005446
SN  - 1533-3884
SN  - 0731-5090
SN  - 0162-3192
VL  - 44
IS  - 5
SP  - 1053
EP  - 1061
ER  - 
TY  - RPRT
A1  - Stölzle-Feix, Sonja
A1  - Thomas, Ulrich
A1  - Engelstädter, Max
A1  - Goßmann, Matthias
A1  - Linder, Peter
A1  - Staat, Manfred
A1  - Raman, Aravind Hariharan
A1  - Jung, Alexander
A1  - Fertig, Niels
T1  - Plattformtechnologie für kardiale Sicherheitspharmakologie basierend auf teilsynthetischem Herzmuskelgewebe (FLEXcyte) : gemeinsamer FuE-Abschlussbericht aller Partner des Verbundprojektes : Projektlaufzeit: 01.10.2018 bis 30.09.2020
Y1  - 2021
U6  - https://doi.org/10.2314/KXP:1813208581
N1  - Förderkennzeichen BMBF 02P18K020-021
Verbundnummer 01185221
PB  - Nanion Technologies GmbH
CY  - München
ER  - 
TY  - CHAP
A1  - Schulte, Maximilian
A1  - Eggert, Mathias
T1  - Predicting hourly bitcoin prices based on long short-term memory neural networks
T2  - Proceedings of the International Conference on Wirtschaftsinformatik (WI) 2021
N2  - Bitcoin is a cryptocurrency and is considered a high-risk asset class whose price changes are difficult to predict. Current research focusses on daily price movements with a limited number of predictors. The paper at hand aims at identifying measurable indicators for Bitcoin price movements and the development of a suitable forecasting model for hourly changes. The paper provides three research contributions. First, a set of significant indicators for predicting the Bitcoin price is identified. Second, the results of a trained Long Short-term Memory (LSTM) neural network that predicts price changes on an hourly basis is presented and compared with other algorithms. Third, the results foster discussions of the applicability of neural nets for stock price predictions. In total, 47 input features for a period of over 10 months could be retrieved to train a neural net that predicts the Bitcoin price movements with an error rate of 3.52 %.
Y1  - 2021
N1  - 16th International Conference on Wirtschaftsinformatik,
March 2021, Essen, Germany
ER  - 
TY  - JOUR
A1  - Kezerashvili, Roman Ya
A1  - Dachwald, Bernd
T1  - Preface: Solar sailing: Concepts, technology, and missions II
JF  - Advances in Space Research
Y1  - 2021
U6  - https://doi.org/10.1016/j.asr.2021.01.037
SN  - 0273-1177
VL  - 67
IS  - 9
SP  - 2559
EP  - 2560
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - THES
A1  - Ossenkop, Birte
T1  - Prepare to care: Kampagne für mehr Unterstützung und Wertschätzung von Young Carern durch ihr direktes Lebensumfeld
N2  - In jeder Schulklasse in Deutschland gibt es laut Statistik einen bis zwei Young Carer. Das sind Kinder und Jugendliche, die ein Familienmitglied pflegen. Doch wegen Unverständnis und Ausgrenzung seitens ihres sozialen Umfeldes vertrauen sich Young Carer niemandem an. Es mangelt schlichtweg an öffentlichem Bewusstsein für das Phänomen.
Die Kampagne #nichtbloßjung soll das ändern. Sie zeigt einer jungen Zielgruppe, was es bedeutet, nicht bloß jung, sondern Young Carer zu sein. Dabei regt sie dazu an, ebenfalls #nichtbloßjung zu bleiben, sondern als „Young Supporter“ die Young Carer zu unterstützen. Dazu wird diverse Informationsmaterial sowie ein kostenloses Armband bereitgestellt. Die Armbandtragenden zeigen so, dass sie Young Carer unterstützen und als Ansprechpersonen zur Verfügung stehen. So lernen Young Carer, dass sie mit ihrer Situation nicht allein sind und an wen sie sich gegebenenfalls wenden können.
KW  - Young Carer
KW  - Kampagne
KW  - Kinder
KW  - Sensibilisierung
KW  - Aufklärung
Y1  - 2021
PB  - FH Aachen
CY  - Aachen
ER  - 
TY  - INPR
A1  - Ringers, Christa
A1  - Bialonski, Stephan
A1  - Solovev, Anton
A1  - Hansen, Jan N.
A1  - Ege, Mert
A1  - Friedrich, Benjamin M.
A1  - Jurisch-Yaksi, Nathalie
T1  - Preprint: Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves
T2  - bioRxiv
N2  - Motile cilia are hair-like cell extensions present in multiple organs of the body. How cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine here experiments, novel analysis tools, and theory to address this knowledge gap. We investigate collective dynamics of cilia in the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Despite the fact that synchronization is local only, we observed global patterns of traveling metachronal waves across the multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right nose, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment are sufficient to generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.
Y1  - 2021
U6  - https://doi.org/10.1101/2021.11.23.469646
N1  - Veröffentlicht in eLife 12:e77701 (https://doi.org/10.7554/eLife.77701).
ER  - 
TY  - CHAP
A1  - Hoegen, Anne von
A1  - Doncker, Rik W. De
A1  - Bragard, Michael
A1  - Hoegen, Svenja von
T1  - Problem-based learning in automation engineering: performing a remote laboratory aession aerving various educational attainments
T2  - 2021 IEEE Global Engineering Education Conference (EDUCON)
N2  - During the Covid-19 pandemic, vocational colleges, universities of applied science and technical universities often had to cancel laboratory sessions requiring students’ attendance. These above of all are of decisive importance in order to give learners an understanding of theory through practical work.This paper is a contribution to the implementation of distance learning for laboratory work applicable for several upper secondary educational facilities. Its aim is to provide a paradigm for hybrid teaching to analyze and control a non-linear system depicted by a tank model. For this reason, we redesign a full series of laboratory sessions on the basis of various challenges. Thus, it is suitable to serve different reference levels of the European Qualifications Framework (EQF).We present problem-based learning through online platforms to compensate the lack of a laboratory learning environment. With a task deduced from their future profession, we give students the opportunity to develop own solutions in self-defined time intervals. A requirements specification provides the framework conditions in terms of time and content for students having to deal with the challenges of the project in a self-organized manner with regard to inhomogeneous previous knowledge. If the concept of Complete Action is introduced in classes before, they will automatically apply it while executing the project.The goal is to combine students’ scientific understanding with a procedural knowledge. We suggest a series of remote laboratory sessions that combine a problem formulation from the subject area of Measurement, Control and Automation Technology with a project assignment that is common in industry by providing extracts from a requirements specification.
Y1  - 2021
U6  - https://doi.org/10.1109/EDUCON46332.2021.9453925
N1  - 2021 IEEE Global Engineering Education Conference (EDUCON), 21-23 April 2021, Vienna, Austria
SP  - 1605
EP  - 1614
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - CHAP
A1  - Schmidt, Thomas
A1  - Kasch, Susanne
A1  - Eichler, Fabian
A1  - Thurn, Laura
T1  - Process strategies on laser-based melting of glass powder
T2  - LiM 2021 proceedings
N2  - This paper presents the laser-based powder bed fusion (L-PBF) using various glass powders (borosilicate and quartz glass). Compared to metals, these require adapted process strategies. First, the glass powders were characterized with regard to their material properties and their processability in the powder bed. This was followed by investigations of the melting behavior of the glass powders with different laser wavelengths (10.6 µm, 1070 nm). In particular, the experimental setup of a CO2 laser was adapted for the processing of glass powder. An experimental setup with integrated coaxial temperature measurement/control and an inductively heatable build platform was created. This allowed the L-PBF process to be carried out at the transformation temperature of the glasses. Furthermore, the component’s material quality was analyzed on three-dimensional test specimen with regard to porosity, roughness, density and geometrical accuracy in order to evaluate the developed L-PBF parameters and to open up possible applications.
KW  - 3D-printing
KW  - glass
KW  - additive manufactureing
KW  - laser based powder fusion
Y1  - 2021
N1  - LiM (Lasers in Manufacturing) 2021, June 21 - 24, 2021, online
ER  - 
TY  - BOOK
A1  - Pieper, Martin
T1  - Quantum mechanics: Introduction to mathematical formulation
N2  - Anyone who has always wanted to understand the hieroglyphs on Sheldon's blackboard in the TV series The Big Bang Theory or who wanted to know exactly what the fate of Schrödinger's cat is all about will find a short, descriptive introduction to the world of quantum mechanics in this essential. The text particularly focuses on the mathematical description in the Hilbert space. The content goes beyond popular scientific presentations, but is nevertheless suitable for readers without special prior knowledge thanks to the clear examples.
KW  - Quantenmechanik
KW  - Hilbert Room
KW  - Postulates
KW  - Schrödingers cat
KW  - Operators
Y1  - 2021
SN  - 978-3-658-32644-9
SN  - 978-3-658-32645-6
U6  - https://doi.org/10.1007/978-3-658-32645-6
PB  - Springer
CY  - Wiesbaden
ER  - 
TY  - THES
A1  - Flohr, Katharina Sophie
T1  - Real:ly?: Perspektiven & soziokulturelle Unterschiede in der Berichterstattung
N2  - Wie real ist unsere Realität? Wie »wirklich« ist das, was wir wahrnehmen und wie »wahr« kann die »Wahrheit« eigentlich sein? Medial vermittelte Informationen spielen für den Prozess der Meinungsbildung eine entscheidende Rolle. In der Wanderausstellung real:ly? geht es um einen Perspektivwechsel. Am Beispiel der »Atomwaffentests auf den Marshallinseln« wird das medial erzeugte Bild amerikanischer Berichterstattung persönlichen Geschichten der Marshaller*innen gegenübergestellt: Technologischer Fortschritt, das Wettrüsten mit der UdSSR und die Macht über die Atombombe treffen auf Erzählungen über Zwangsumsiedlung, Krankheit, Ausbeutung und Abhängigkeit. real:ly? soll daran erinnern, die andere Seite der Medaille zu bedenken und eine andere Perspektive einzunehmen, bevor man seine Meinung bildet. Denn alles, was wir zu wissen glauben, ist nur ein kleiner Teil der ganzen Geschichte.
KW  - Atomwaffentests
KW  - Marshallinseln
KW  - nukleares Erbe
KW  - Klimawandel
KW  - Berichterstattung
Y1  - 2021
N1  - Für diese Arbeit steht kein Volltext zur Verfügung.
PB  - FH Aachen
CY  - Aachen
ER  - 
TY  - CHAP
A1  - Ritschel, Konstantin
A1  - Stenzel, Adina
A1  - Czarnecki, Christian
A1  - Hong, Chin-Gi
ED  - Gesellschaft für Informatik e.V. (GI), 
T1  - Realizing robotic process automation potentials: an architectural perspective on a real-life implementation case
T2  - GI Edition Proceedings Band 314 "INFORMATIK 2021" Computer Science & Sustainability
N2  - The initial idea of Robotic Process Automation (RPA) is the automation of business processes through a simple emulation of user input and output by software robots. Hence, it can be assumed that no changes of the used software systems and existing Enterprise Architecture (EA) is
required. In this short, practical paper we discuss this assumption based on a real-life implementation project. We show that a successful RPA implementation might require architectural work during analysis, implementation, and migration. As practical paper we focus on exemplary lessons-learned and new questions related to RPA and EA.
KW  - Robotic Process Automation
KW  - Enterprise Architecture
KW  - Implementation Case
Y1  - 2021
SN  - 9783885797081
U6  - https://doi.org/10.18420/informatik2021-108
SN  - 1617-5468
N1  - INFORMATIK 2021 – 51. Jahrestagung der Gesellschaft für Informatik, 27. September – 01. Oktober 2021 / Virtuell
SP  - 1303
EP  - 1311
PB  - Köllen
CY  - Bonn
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Recent progress in silicon-based biologically sensitive field-effect devices
JF  - Current Opinion in Electrochemistry
N2  - Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor’s recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential.
Y1  - 2021
U6  - https://doi.org/10.1016/j.coelec.2021.100811
SN  - 2451-9103
IS  - Article number: 100811
PB  - Elsevier
CY  - Amsterdam
ER  -