TY  - JOUR
A1  - Jens, Otto
A1  - Kaldenhoff, E.
A1  - Kirschner-Hermanns, R.
A1  - Mühl, Thomas
A1  - Klinge, Uwe
T1  - Elongation of textile pelvic floor implants under load is related to complete loss of effective porosity, thereby favoring incorporation in scar plates
JF  - Journal of biomedical materials research. Part A
N2  - Use of textile structures for reinforcement of pelvic floor structures has to consider mechanical forces to the implant, which are quite different to the tension free conditions of the abdominal wall. Thus, biomechanical analysis of textile devices has to include the impact of strain on stretchability and effective porosity. Prolift® and Prolift + M®, developed for tension free conditions, were tested by measuring stretchability and effective porosity applying mechanical strain. For comparison, we used Dynamesh-PR4®, which was designed for pelvic floor repair to withstand mechanical strain. Prolift® at rest showed moderate porosity with little stretchability but complete loss of effective porosity at strain of 4.9 N/cm. Prolift + M® revealed an increased porosity at rest, but at strain showed high stretchability, with subsequent loss of effective porosity at strain of 2.5 N/cm. Dynamesh PR4® preserved its high porosity even under strain, but as consequence of limited stretchability. Though in tension free conditions Prolift® and Prolift + M® can be considered as large pore class I meshes, application of mechanical strain rapidly lead to collapse of pores. The loss of porosity at mechanical stress can be prevented by constructions with high structural stability. Assessment of porosity under strain was found helpful to define requirements for pelvic floor devices. Clinical studies have to prove whether devices with high porosity as well as high structural stability can improve the patients' outcome.
Y1  - 2014
U6  - https://doi.org/10.1002/jbm.a.34767
SN  - 1552-4965
VL  - 102
IS  - 4
SP  - 1079
EP  - 1084
PB  - Wiley
CY  - New York
ER  - 
TY  - GEN
A1  - Alt, Helmut
T1  - Energiekonzept mit kurzer Brücke zu witterungsabhängigen, hohen Strompreisen :  KTG Jahrestagung in Stuttgart, 22.- 24. 5. 2012
Y1  - 2014
SP  - 1
EP  - 60
ER  - 
TY  - THES
A1  - Reyes Ochoa, Leonel
T1  - Engineering aspects of a parabolic trough collector field with direct steam generation and an organic rankine cycle
Y1  - 2014
N1  - Aachen, Fachhochsch., Masterarbeit, 2014
PB  - Fachhochschule Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Wagner, Patrick
A1  - Doll, Theodor
A1  - Schöning, Michael Josef
T1  - Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Schöning (eds.)
JF  - Physica status solidi (A) : Applications and materials science
Y1  - 2014
U6  - https://doi.org/10.1002/pssa.201470241
SN  - 1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1339
EP  - 1339
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Miyamoto, K.
A1  - Seki, K.
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination
JF  - Procedia Engineering
N2  - The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm.
Y1  - 2014
U6  - https://doi.org/10.1016/j.proeng.2014.11.563
SN  - 1877-7058
N1  - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014>
VL  - 87
SP  - 612
EP  - 615
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Duwe, Anna-Maria
A1  - Wiesen, Sebastian
A1  - Sieker, Tim
A1  - Ulber, Roland
T1  - Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids
JF  - Bioresource Technology
N2  - The development of a cost-effective hydrolysis for crude cellulose is an essential part of biorefinery developments. To establish such high solid hydrolysis, a new solid state reactor with static mixing is used. However, concentrations >10% (w/w) cause a rate and yield reduction of enzymatic hydrolysis. By optimizing the synergetic activity of cellulolytic enzymes at solid concentrations of 9%, 17% and 23% (w/w) of crude Organosolv cellulose, glucose concentrations of 57, 113 and 152 g L⁻¹ are reached. However, the glucose yield decreases from 0.81 to 0.72gg⁻¹ at 17% (w/w). Optimal conditions for hydrolysis scale-up under minimal enzyme addition are identified. As result, at 23% (w/w) crude cellulose the glucose yield increases from 0.29 to 0.49gg⁻¹. As proof of its applicability, biobutanol, succinic and itaconic acid are produced with the crude hydrolysate. The potential of the substrate is proven e.g. by a high butanol yield of 0.33gg⁻¹.
Y1  - 2014
U6  - https://doi.org/10.1016/j.biortech.2014.06.052
VL  - 167
SP  - 447
EP  - 455
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Krischer, M.
A1  - Wenzel, L.
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor
JF  - Procedia Engineering
N2  - A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.
KW  - Field-effect sensor
KW  - enzymatic (bio)degradation
KW  - poly(d, l-lactic acid)
KW  - in-situ monitoring
KW  - impedance spectroscopy
Y1  - 2014
U6  - https://doi.org/10.1016/j.proeng.2014.11.689
SN  - 1877-7058
N1  - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014>
VL  - 87
SP  - 1314
EP  - 1317
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bandodkar, Amay J.
A1  - Molinnus, Denise
A1  - Mirza, Omar
A1  - Guinovart, Tomas
A1  - Windmiller, Joshua R.
A1  - Valdes-Ramirez, Gabriela
A1  - Andrade, Francisco J.
A1  - Schöning, Michael Josef
A1  - Wang, Joseph
T1  - Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring
JF  - Biosensors and bioelectronics
N2  - This article describes the fabrication, characterization and application of an epidermal temporary-transfer tattoo-based potentiometric sensor, coupled with a miniaturized wearable wireless transceiver, for real-time monitoring of sodium in the human perspiration. Sodium excreted during perspiration is an excellent marker for electrolyte imbalance and provides valuable information regarding an individual's physical and mental wellbeing. The realization of the new skin-worn non-invasive tattoo-like sensing device has been realized by amalgamating several state-of-the-art thick film, laser printing, solid-state potentiometry, fluidics and wireless technologies. The resulting tattoo-based potentiometric sodium sensor displays a rapid near-Nernstian response with negligible carryover effects, and good resiliency against various mechanical deformations experienced by the human epidermis. On-body testing of the tattoo sensor coupled to a wireless transceiver during exercise activity demonstrated its ability to continuously monitor sweat sodium dynamics. The real-time sweat sodium concentration was transmitted wirelessly via a body-worn transceiver from the sodium tattoo sensor to a notebook while the subjects perspired on a stationary cycle. The favorable analytical performance along with the wearable nature of the wireless transceiver makes the new epidermal potentiometric sensing system attractive for continuous monitoring the sodium dynamics in human perspiration during diverse activities relevant to the healthcare, fitness, military, healthcare and skin-care domains.
Y1  - 2014
U6  - https://doi.org/10.1016/j.bios.2013.11.039
SN  - 1873-4235 (E-Journal); 0956-5663 (Print)
VL  - 54
SP  - 603
EP  - 609
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Buniatyan, V. V.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Rustamyan, L. G.
A1  - Hovnikyan, H. H.
T1  - Equivalent circuit and optimization of impedance characteristics of an electrolyte conductivity sensor
T2  - Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering
Y1  - 2014
VL  - Iss. 17
IS  - No. 1
SP  - 69
EP  - 76
ER  - 
TY  - JOUR
A1  - Gellert, Christoph
A1  - Butenweg, Christoph
T1  - Seismic analysis of masonry structures in German earthquake zones according to DIN EN 1998-1
T1  - Erdbebenbemessung von Mauerwerksbauten in deutschen Erdbebengebieten nach DIN EN 1998-1
JF  - Mauerwerk : European journal of masonry
N2  - Die Erdbeben in Albstadt 1978 (Magnitude 5,7), Roermond 1992 (Magnitude 5,9) oder in Waldkirch 2004 (Magnitude 5,1) haben verdeutlicht, dass die erdbebensichere Auslegung von Mauerwerksbauten auch in Deutschland von großer Bedeutung ist. Bereits im Jahr 1981 wurde die DIN 4149 (1981) “Bauten in deutschen Erdbebengebieten – Lastannahmen, Bemessung und Ausführung üblicher Hochbauten“ eingeführt, in der aber für Mauerwerksbauten nur wenige Anforderungen gestellt wurden. Diese Norm wurde durch den NABau-Arbeitsausschuss “Erdbeben; Sonderfragen“ des Deutschen Instituts für Normung e.V. (DIN) auf Grundlage des Eurocode 8 (2004) vollständig überarbeitet und durch die DIN 4149 (2005) abgelöst, die umfangreiche Regelungen für die seismische Auslegung von Mauerwerksbauten enthält. Mittlerweile liegen die DIN EN 1998-1 (2010) und der Nationale Anhang DIN EN 1998-1/NA (2011) vor, die nach Einarbeitung der Ergebnisse der durchgeführten Anwendungserprobung bauaufsichtlich eingeführt und die DIN 4149 (2005) ersetzen werden. Der folgende Beitrag gibt einen Überblick über die seismische Berechnung und Bemessung von Mauerwerksbauten nach dem europäischen Regelwerk und illustriert deren Anwendung an einem baupraktischen Beispiel.
Y1  - 2014
U6  - https://doi.org/10.1002/dama.201400626
SN  - 1437-1022 (E-Journal); 1432-3427 (Print)
VL  - 18
IS  - 3-4
SP  - 188
EP  - 196
PB  - Ernst & Sohn
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Butenweg, Christoph
A1  - Norda, H.
T1  - Erdbebenberechnung von Mauerwerksbauten nach DIN EN 1998-1:2010-12
T2  - Mauerwerksbau-Praxis nach Eurocode / Schubert, Schneider, Schoch (Hrsg.). - 3., vollständig überarbeitete Auflage
Y1  - 2014
SN  - 978-3-410-22739-7
SP  - 367
EP  - 412
PB  - Beuth
CY  - Berlin, Wien, Zürich
ER  - 
TY  - JOUR
A1  - Thomas, Axel
A1  - Wassenberg, Gerd
T1  - Erfolgreich sein im Kampf um die besten Talente : Employer Branding
JF  - Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen
Y1  - 2014
N1  - Nur noch nach Anfrage bei der IHK Aachen erhältlich: https://www.ihk.de/aachen/servicemarken/presse/medien-der-ihk/wirtschaftliche-nachrichten/aktuelle-ausgaben
PB  - IHK Aachen
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Pyschny, D.
A1  - Döring, Bernd
A1  - Feldmann, M.
T1  - Ermittlung der thermischen Leistungsfähigkeit des neuartigen multifunktionalen Verbunddeckensystems InaDeck
JF  - Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen
Y1  - 2014
SN  - 0005-6650
N1  - Printausgabe in der Bibliothek Bayernallee vorhanden: 13 Z 049-2014
VL  - 89
IS  - 3
SP  - 116
EP  - 124
PB  - VDI Fachmedien
CY  - Düsseldorf
ER  - 
TY  - GEN
A1  - Jacobs, Stephan
T1  - Es gibt keine nichtfunktionalen Tests. Es gibt nur nichtfunktionale Anforderungen!
Y1  - 2014
ER  - 
TY  - BOOK
A1  - Bernecker, Andreas
T1  - Essays in Empirical Political Economics
Y1  - 2014
N1  - Mannheim, Univ., Diss., 2014.
ER  - 
TY  - JOUR
A1  - Meyer, Udo
A1  - Butenweg, Christoph
A1  - Fehling, Ekkehard
T1  - EU-Projekt INSYSME : innovative Systeme für erdbebentaugliche Ausfachungswände aus Ziegelmauerwerk
JF  - Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt
Y1  - 2014
SN  - 1436-4867 (E-Journal); 0005-6650 (Print)
VL  - 89 (2014)
IS  - April
SP  - S14
EP  - S15
PB  - VDI Fachmedien
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Meyer, Udo
A1  - Fehling, Ekkehard
T1  - EU-Projekt INSYSME: Innovative Techniken für erdbebensichere Ausfachungswände aus Ziegelmauerwerk in Stahlbetonrahmentragwerken
JF  - Mauerwerk : European journal of masonry
N2  - Am 1. Oktober 2013 ist das auf drei Jahre angelegte EU-Forschungsprojekt INSYSME – Innovative Systeme für erdbebentaugliche Ausfachungswände aus Ziegelmauerwerk in Stahlbetonrahmentragwerken – gestartet. Unter der Koordination der Universität Padua beteiligen sich 16 Partner aus sechs europäischen Ländern (Deutschland, Griechenland, Italien, Portugal, Rumänien, Türkei). Als deutsche Partner nehmen die Arbeitsgemeinschaft Mauerziegel aus Bonn, die Universität Kassel sowie das Ingenieurbüro SDA-engineering GmbH aus Herzogenrath, teil. Ziel der deutschen Partner ist die Entwicklung von innovativen Ausfachungssystemen aus monolithischem wärmedämmenden Ziegelmauerwerk, mit denen nicht nur eine erhöhte Erdbebensicherheit, sondern auch die sichere Erfüllung der steigenden Anforderungen aus Windbeanspruchungen gewährleistet werden können. Die Forschungsergebnisse sollen vom Partner SDA-engineering GmbH in die bereits seit einigen Jahren verfügbare Softwarelösung MINEA [1] integriert werden. Weitere Informationen stehen auf den Websites des Projektes [2] zur Verfügung. Im vorliegenden Beitrag werden nach einer kurzen thematischen Einführung die Ergebnisse von Tastversuchen an senkrecht zur Ebene belasteten Ausfachungswänden aus Planziegelmauerwerk vorgestellt. Im Anschluss wird das geplante Arbeitsprogramm der deutschen Partner im Projekt INSYSME beschrieben.
Y1  - 2014
U6  - https://doi.org/10.1002/dama.201400612
SN  - 1437-1022 (E-Journal); 1432-3427 (Print)
VL  - 18
IS  - 2
SP  - 78
EP  - 81
PB  - Ernst & Sohn
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Salpati, Laurent
A1  - Chu, Xiaoyan
A1  - Chen, Liangfu
A1  - Prasad, Bhagwat
A1  - Dallas, Shannon
A1  - Evers, Raymond
A1  - Mamaril-Fishman, Donna
A1  - Geier, Ethan G.
A1  - Kehler, Jonathan
A1  - Kunta, Jeevan
A1  - Mezler, Mario
A1  - Laplanche, Loic
A1  - Pang, Jodie
A1  - Soars, Matthew G.
A1  - Unadkat, Jashvant D.
A1  - van Waterschoot, Robert A.B.
A1  - Yabut, Jocelyn
A1  - Schinkel, Alfred H.
A1  - Scheer, Nico
A1  - Rode, Anja
T1  - Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
JF  - Drug Metabolism and Disposition
N2  - Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography–tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.
Y1  - 2014
U6  - https://doi.org/10.1124/dmd.114.057976
SN  - 1521-009X
VL  - 42
IS  - 8
SP  - 1301
EP  - 1313
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Lehnertz, Klaus
A1  - Ansmann, Gerrit
A1  - Bialonski, Stephan
A1  - Dickten, Henning
A1  - Geier, Christian
A1  - Porz, Stephan
T1  - Evolving networks in the human epileptic brain
JF  - Physica D: Nonlinear Phenomena
N2  - Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives.
Y1  - 2014
U6  - https://doi.org/10.1016/j.physd.2013.06.009
SN  - 0167-2789
VL  - 267
SP  - 7
EP  - 15
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Dickhoff, J.
A1  - Keinz, Jan
A1  - Anis, H. A.
A1  - Parente, A.
A1  - Hendrick, P.
T1  - Experimental and numerical study of the micromix combustion principle applied for hydrogen and hydrogen-rich syngas as fuel with increased energy density for industrial gas turbine applications
JF  - Energy procedia
N2  - The Dry Low NOx (DLN) Micromix combustion principle with increased energy density is adapted for the industrial gas turbine APU GTCP 36-300 using hydrogen and hydrogen-rich syngas with a composition of 90%-Vol. hydrogen (H₂) and 10%-Vol. carbon-monoxide (CO). Experimental and numerical studies of several combustor geometries for hydrogen and syngas show the successful advance of the DLN Micromix combustion from pure hydrogen to hydrogen-rich syngas. The impact of the different fuel properties on the combustion principle and aerodynamic flame stabilization design laws, flow field, flame structure and emission characteristics is investigated by numerical analysis using a hybrid Eddy Break Up combustion model and validated against experimental results.
Y1  - 2014
U6  - https://doi.org/10.1016/j.egypro.2014.12.201
SN  - 1876-6102 (E-Journal)
IS  - 61
SP  - 1736
EP  - 1739
PB  - Elsevier
CY  - Amsterdam
ER  -