TY  - JOUR
A1  - Schroth, P.
A1  - Schöning, Michael Josef
A1  - Kordos, P.
A1  - Lüth, H.
A1  - Schütz, S.
A1  - Weißbecker, B.
A1  - Hummel, Hans E.
T1  - Insectbased BioFETs with improved signal characteristics
JF  - Biosensors & Bioelectronics. 14 (1999), H. 3
Y1  - 1999
SN  - 0956-5663
SP  - 303
EP  - 308
ER  - 
TY  - JOUR
A1  - Schütz, S.
A1  - Czynski, J.
A1  - Hummel, Hans E.
A1  - Schöning, Michael Josef
A1  - Schroth, P.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Insect meets microelectronics: A BioFET as a first step to bioelectronic microsystems
JF  - Transducers '99 : proceedings of the Tenth International Conference on Solid-State Sensors and Actuators ; 7 - 10 June, 1999, Sendai, Japan / ed.: S. Middelhoek
Y1  - 2000
N1  - International Conference on Solid State Sensors and Actuators <10, 1999, Sendai, Miyagi-ken> ; Transducers '99 ; (10 : ; 1999.06.07-10 : ; Sendai)
SP  - 1104
EP  - 1107
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schroth, Peter
A1  - Lüth, Hans
A1  - Hummel, Hans E.
A1  - Schütz, Stefan
T1  - Insect chemoreceptors coupled to silicon transistors as innovative biosensors
JF  - Proceedings of SPIE. 4205 (2001)
Y1  - 2001
SP  - 152
EP  - 162
ER  - 
TY  - JOUR
A1  - Kloock, Joachim P.
A1  - Mourzina, Y.G.
A1  - Ermolenko, Y.
A1  - Doll, T.
A1  - Schubert, J.
A1  - Schöning, Michael Josef
T1  - Inorganic thin-film sensor membranes with PLD-prepared chalcogenide glasses: Challenges and implementation
JF  - Sensors. 4 (2004), H. 10
Y1  - 2004
SN  - 1424-8220
SP  - 156
EP  - 162
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schubert, J
A1  - Kloock, Joachim P.
A1  - Zander, W.
A1  - Mourzina, Y. G.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
T1  - Innovative thin film techniques for microfabricating electrochemical sensors
JF  - Lecture Notes of the ICB Seminars
Y1  - 2002
SP  - 55
EP  - 66
PB  - MCB
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Schubert, Joachim P.
A1  - Kloock, Joachim P.
A1  - Zander, W.
A1  - Mourzina, Y. G.
A1  - Legin, A.
A1  - Vlasov, Y. G.
A1  - Lüth, H.
T1  - Innovative thin film techniques for microfabricating electrochemical sensors
JF  - Biocybernetics and Biomedical Engineering. 21 (2001), H. 4
Y1  - 2001
SN  - 0208-5216
SP  - 107
EP  - 119
ER  - 
TY  - JOUR
A1  - Hamad, E. M.
A1  - Bilatto, S. E. R.
A1  - Adly, N. Y.
A1  - Correa, D. S.
A1  - Wolfrum, B.
A1  - Schöning, Michael Josef
A1  - Offenhäusser, A.
A1  - Yakushenko, A.
T1  - Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices
JF  - Lab on a Chip
N2  - Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.
Y1  - 2016
U6  - http://dx.doi.org/10.1039/C5LC01195G
SN  - 1473-0189
VL  - 16
IS  - 1
SP  - 70
EP  - 74
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Bertz, Morten
A1  - Schöning, Michael Josef
A1  - Molinnus, Denise
A1  - Homma, Takayuki
T1  - Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping
JF  - Physica status solidi (a) applications and materials science
N2  - To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem.
KW  - hydrogen peroxide
KW  - optical spore trapping
KW  - Raman spectroscopy
KW  - sterilization conditions
KW  - temperature
Y1  - 2024
U6  - http://dx.doi.org/10.1002/pssa.202300866
SN  - 1862-6319 (Online)
SN  - 1862-6300 (Print)
IS  - Early View
PB  - Wiley-VCH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Janus, Kevin Alexander
A1  - Achtsnicht, Stefan
A1  - Tempel, Laura
A1  - Drinic, Aleksaner
A1  - Kopp, Alexander
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Influence of fibroin membrane composition and curing parameters on the performance of a biodegradable enzymatic biosensor manufactured from Silicon-Free Carbon
JF  - Physica status solidi : pss. A, Applications and materials science
N2  - Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen-printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5–10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.
KW  - amperometric biosensors
KW  - biocompatible
KW  - biodegradabl
KW  - encapsulation materials
KW  - fibroin
Y1  - 2023
U6  - http://dx.doi.org/10.1002/pssa.202300081
SN  - 1862-6300 (Print)
SN  - 1862-6319 (Online)
N1  - Corresponding author: Michael J. Schöning
VL  - 220
IS  - 22
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Molinnus, Denise
A1  - Beging, Stefan
A1  - Schöning, Michael Josef
T1  - Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection
JF  - Analytical chemistry
N2  - The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor’s surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance–voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.
Y1  - 2014
U6  - http://dx.doi.org/10.1021/ac500458s
SN  - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)
VL  - 86
IS  - 11
SP  - 5370
EP  - 5375
PB  - ACS Publications
CY  - Columbus
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Schroth, P.
A1  - Töpler, A.
A1  - Schöning, Michael Josef
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Improving the detection limit of a capacitive sensor by means of a diffusion barrier
JF  - Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1
Y1  - 1998
SN  - 0-7503-0595-9
N1  - Eurosensors ; (12, 1998, Southampton) ; UK Conference on Sensors and Their Applications ; (9, 1998, Southampton)
SP  - 507
EP  - 510
PB  - Inst. of Physics Publ.
CY  - Bristol [u.a.]
ER  - 
TY  - JOUR
A1  - Schroth, P.
A1  - Schöning, Michael Josef
A1  - Schütz, S.
A1  - Epanya, P.
A1  - Steffen, A.
A1  - Weißbecker, B.
A1  - Hummel, Hans E.
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Improving the bioelectronic interface of an antenna/chip biosensor – technological aspects
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague)
SP  - 569
EP  - 572
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Miyamoto, Koichiro
A1  - Seki, Kosuke
A1  - Suto, Takeyuki
A1  - Werner, Frederik
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers
JF  - Sensor and Actuators B: Chemical
N2  - The chemical imaging sensor is a semiconductor-based chemical sensor capable of visualizing pH and ion distributions. The spatial resolution depends on the lateral diffusion of photocarriers generated by illumination of the semiconductor substrate. In this study, two types of optical setups, one based on a bundle of optical fibers and the other based on a binocular tube head, were developed to project a hybrid illumination of a modulated light beam and a ring-shaped constant illumination onto the sensor plate. An improved spatial resolution was realized by the ring-shaped constant illumination, which suppressed lateral diffusion of photocarriers by enhanced recombination due to the increased carrier concentration.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.snb.2018.07.016
SN  - 0925-4005
VL  - 273
SP  - 1328
EP  - 1333
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Delle, Lotta E.
A1  - Huck, Christina
A1  - Bäcker, Matthias
A1  - Müller, Frank
A1  - Grandthyll, Samuel
A1  - Jacobs, Karin
A1  - Lilischkis, Rainer
A1  - Vu, Xuan T.
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Thoelen, Roland
A1  - Weil, Maryam
A1  - Ingebrandt, Sven
T1  - Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide
JF  - Physica status solidi (a)
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431863
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1327
EP  - 1334
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Riedel, Marc
A1  - Kartchemnik, Julia
A1  - Schöning, Michael Josef
A1  - Lisdat, Fred
T1  - Impedimetric DNA detection – steps forward to sensorial application
JF  - Analytical chemistry
N2  - This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away.
Y1  - 2014
U6  - http://dx.doi.org/10.1021/ac501800q
SN  - 1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)
VL  - 86 (2014)
IS  - 15
SP  - 7867
EP  - 7874
PB  - ACS Publications
CY  - Columbus
ER  - 
TY  - CHAP
A1  - Oberländer, Jan
A1  - Arreola, Julio
A1  - Hansen, Christina
A1  - Greeff, Anton
A1  - Mayer, Marlena
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Impedimetric Biosensor to Enable Fast Evaluation of Gaseous Sterilization Processes
T2  - MDPI Proceedings
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040435
N1  - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017
VL  - 1
IS  - 4
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers
JF  - Physica Status Solidi (A)
N2  - Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/pssa.201200941
SN  - 1521-396X ; 0031-8965
VL  - 210
IS  - 5
SP  - 905
EP  - 910
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Mai, D.-T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
T1  - Impedance effect of an ion-sensitive membrane: characterisation of an EMIS sensor by impedance spectroscopy, capacitance-voltage and constant-capacitance method
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 423
EP  - 428
ER  - 
TY  - JOUR
A1  - Mourzina, Ioulia G.
A1  - Yoshinobu, Tatsuo
A1  - Ermolenko, Yuri E.
A1  - Vlasov, Yuri G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors
JF  - Microchimica Acta. 144 (2004), H. 1-3
Y1  - 2004
SN  - 0026-3672
SP  - 41
EP  - 50
ER  - 
TY  - JOUR
A1  - Mourzina, I.G.
A1  - Yoshinobu, T.
A1  - Ermolenko, Y.E.
A1  - Vlasov, Y. G.
A1  - Schöning, Michael Josef
A1  - Iwasaki, H.
T1  - Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors
JF  - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors
Y1  - 2004
N1  - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba)
SP  - 788
EP  - 789
PB  - Japan Association of Chemical Sensors
CY  - Fukuoka
ER  -