TY  - JOUR
A1  - Pilas, Johanna
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Screen-printed carbon electrodes modified with graphene oxide for the design of a reagent-free NAD+-dependent biosensor array
JF  - Analytical Chemistry
Y1  - 2019
U6  - https://doi.org/10.1021/acs.analchem.9b04481
VL  - 91
IS  - 23
SP  - 15293
EP  - 15299
PB  - ACS Publications
CY  - Washington
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Abel, Thomas
A1  - Albracht, Kirsten
A1  - Strüder, Heiko K.
T1  - Reliability of muscular activation patterns and their alterations during incremental handcycling in able-bodied participants
JF  - Sports Biomechanics
Y1  - 2019
U6  - https://doi.org/10.1080/14763141.2019.1593496
SN  - 1752-6116
IS  - Article in press
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Capri, Miriam
A1  - Morsiani, Cristina
A1  - Santoro, Aurelia
A1  - Moriggi, Manuela
A1  - Conte, Maria
A1  - Martucci, Morena
A1  - Bellavista, Elena
A1  - Fabbri, Cristina
A1  - Giampieri, Enrico
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Canepari, Monica
A1  - Longa, Emanuela
A1  - Giulio, Irene Di
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Salvioli, Stefano
A1  - Gelfi, Cecilia
A1  - Franceschi, Claudio
A1  - Narici, Marco
A1  - Rittweger, Jörn
T1  - Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
JF  - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Y1  - 2019
U6  - https://doi.org/10.1096/fj.201801625R
VL  - 33
IS  - 4
SP  - 5168
EP  - 5180
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Geissler, Hanno
A1  - Schöning, Michael Josef
T1  - Rapid methods and sensors for milk quality monitoring and spoilage detection
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.04.040
SN  - 0956-5663
VL  - 140
IS  - Article 111272
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Selmer, Thorsten
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.111332
VL  - 139
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - https://doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Teeman, Eric
A1  - Slabu, Iona
A1  - Krishnan, Kannan M.
T1  - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - https://doi.org/10.1016/j.jmmm.2018.09.041
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 450
EP  - 456
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - https://doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Optimization of the flight technique in ski jumping: the influence of wind
Y1  - 2019
U6  - https://doi.org/10.1016/j.jbiomech.2019.03.023
IS  - Early view
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Baringhaus, Ludwig
A1  - Gaigall, Daniel
T1  - On an asymptotic relative efficiency concept based on expected volumes of confidence regions
JF  - Statistics - A Journal of Theoretical and Applied Statistic
N2  - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.
KW  - Volume of confidence regions
KW  - asymptotic relative efficiency
KW  - likelihood ratio test
KW  - multivariate normal distribution
KW  - multinomial distribution
Y1  - 2019
U6  - https://doi.org/10.1080/02331888.2019.1683560
SN  - 1029-4910
VL  - 53
IS  - 6
SP  - 1396
EP  - 1436
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Gaigall, Daniel
T1  - On a new approach to the multi-sample goodness-of-fit problem
JF  - Communications in Statistics - Simulation and Computation
N2  - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.
KW  - Goodness-of-fit test
KW  - Multi-sample problem
KW  - Parametric bootstrap
Y1  - 2019
U6  - https://doi.org/10.1080/03610918.2019.1618472
SN  - 1532-4141
VL  - 53
IS  - 10
SP  - 2971
EP  - 2989
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Karschuck, T. L.
A1  - Filipov, Y.
A1  - Bollella, P.
A1  - Schöning, Michael Josef
A1  - Katz, E.
T1  - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction
JF  - International Journal of Unconventional Computing
N2  - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Y1  - 2019
SN  - 1548-7199
VL  - 14
IS  - 3-4
SP  - 235
EP  - 242
PB  - Old City Publishing
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Pourshahidi, Ali Mohammad
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
T1  - Multiplex detection of different magnetic beads using frequency scanning in magnetic frequency mixing technique
JF  - Sensors
N2  - In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles’ nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil’s signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements.
KW  - frequency mixing magnetic detection
KW  - magnetic sandwich immunoassay
KW  - multiparametric immunoassays
Y1  - 2019
U6  - https://doi.org/10.3390/s19112599
SN  - 1424-8220
VL  - 19
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lüke, Jan Niklas
A1  - Schubert, Gerrit Alexander
A1  - Dibué-Adjei, Maxine
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Steiger, Hans-Jakob
A1  - Hänggi, Daniel
A1  - Kamp, Marcel A.
A1  - Schneider, Toni
A1  - Neumaier, Felix
T1  - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity
JF  - Molecular and Cellular Neuroscience
Y1  - 2019
U6  - https://doi.org/10.1016/j.mcn.2019.03.003
SN  - 1044-7431
VL  - 96
IS  - 4
SP  - 35
EP  - 46
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Slabu, Ioana
A1  - Roeth, Anjali A.
A1  - Engelmann, Ulrich M.
A1  - Wiekhorst, Frank
A1  - Buhl, Eva M.
A1  - Neumann, Ulf P.
A1  - Schmitz-Rode, Thomas
T1  - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro
JF  - Nanotechnology
Y1  - 2019
U6  - https://doi.org/10.1088/1361-6528/ab033e
SN  - 1361-6528
VL  - 30
IS  - 18
SP  - 184004
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue
JF  - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik
Y1  - 2019
U6  - https://doi.org/10.1002/gamm.201900002
SN  - 1522-2608
VL  - 42
IS  - 4
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Schönenborn, Kristina
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
T1  - Measurement of the magnetophoretic velocity of different superparamagnetic beads
JF  - Journal of Magnetism and Magnetic Materials
N2  - The movement of magnetic beads due to a magnetic field gradient is of great interest in different application fields. In this report we present a technique based on a magnetic tweezers setup to measure the velocity factor of magnetically actuated individual superparamagnetic beads in a fluidic environment. Several beads can be tracked simultaneously in order to gain and improve statistics. Furthermore we show our results for different beads with hydrodynamic diameters between 200 and 1000 nm from diverse manufacturers. These measurement data can, for example, be used to determine design parameters for a magnetic separation system, like maximum flow rate and minimum separation time, or to select suitable beads for fixed experimental requirements.
KW  - magnetophoretic velocity
KW  - superparamagnetic bead
KW  - magnetic tweezers
KW  - magnetic separation
KW  - magnetic actuation
Y1  - 2019
U6  - https://doi.org/10.1016/j.jmmm.2018.10.066
SN  - 0304-8853
VL  - 477
IS  - 1
SP  - 244
EP  - 248
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Roeth, A.A.
A1  - Slabu, I.
A1  - Kessler, A.
A1  - Engelmann, Ulrich M.
T1  - Local treatment of pancreatic cancer with magnetic nanoparticles
JF  - HPB
Y1  - 2019
U6  - https://doi.org/10.1016/j.hpb.2019.10.959
SN  - 1365-182X
VL  - 21
IS  - Supplement 3
SP  - S868
EP  - S869
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Meyer, Carolin
A1  - Gaalen, Kerstin van
A1  - Leschinger, Tim
A1  - Scheyerer, Max J.
A1  - Neiss, Wolfram F.
A1  - Staat, Manfred
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement
JF  - BioMed Research International
Y1  - 2019
U6  - https://doi.org/10.1155/2019/9232813
SP  - Article ID 9232813
ER  - 
TY  - JOUR
A1  - Leschinger, Tim
A1  - Besch, Katharina
A1  - Aydin, Cansu
A1  - Staat, Manfred
A1  - Scaal, Martin
A1  - Müller, Lars Peter
A1  - Wegmann, Kilian
T1  - Irreparable rotator cuff tears: a biomechanical comparison of superior capsuloligamentous complex reconstruction techniques and an interposition graft technique
JF  - The Orthopaedic Journal of Sports Medicine
Y1  - 2019
U6  - https://doi.org/10.1177/2325967119864590
VL  - 7
IS  - 8
SP  - 1
EP  - 5
ER  -