TY  - CHAP
A1  - Digel, Ilya
A1  - Sadykov, R.
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations
T2  - Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies
Y1  - 2015
SN  - 9781634826990
SP  - 75
EP  - 99
PB  - Nova Science Publ.
ER  - 
TY  - JOUR
A1  - Waldvogel, Janice
A1  - Freyler, Kathrin
A1  - Helm, Michael
A1  - Monti, Elena
A1  - Stäudle, Benjamin
A1  - Gollhofer, Albert
A1  - Narici, Marco V.
A1  - Ritzmann, Ramona
A1  - Albracht, Kirsten
T1  - Changes in gravity affect neuromuscular control, biomechanics, and muscle-tendon mechanics in energy storage and dissipation tasks
JF  - Journal of Applied Physiology
N2  - This study evaluates neuromechanical control and muscle-tendon interaction during energy storage and dissipation tasks in hypergravity. During parabolic flights, while 17 subjects performed drop jumps (DJs) and drop landings (DLs), electromyography (EMG) of the lower limb muscles was combined with in vivo fascicle dynamics of the gastrocnemius medialis, two-dimensional (2D) kinematics, and kinetics to measure and analyze changes in energy management. Comparisons were made between movement modalities executed in hypergravity (1.8 G) and gravity on ground (1 G). In 1.8 G, ankle dorsiflexion, knee joint flexion, and vertical center of mass (COM) displacement are lower in DJs than in DLs; within each movement modality, joint flexion amplitudes and COM displacement demonstrate higher values in 1.8 G than in 1 G. Concomitantly, negative peak ankle joint power, vertical ground reaction forces, and leg stiffness are similar between both movement modalities (1.8 G). In DJs, EMG activity in 1.8 G is lower during the COM deceleration phase than in 1 G, thus impairing quasi-isometric fascicle behavior. In DLs, EMG activity before and during the COM deceleration phase is higher, and fascicles are stretched less in 1.8 G than in 1 G. Compared with the situation in 1 G, highly task-specific neuromuscular activity is diminished in 1.8 G, resulting in fascicle lengthening in both movement modalities. Specifically, in DJs, a high magnitude of neuromuscular activity is impaired, resulting in altered energy storage. In contrast, in DLs, linear stiffening of the system due to higher neuromuscular activity combined with lower fascicle stretch enhances the buffering function of the tendon, and thus the capacity to safely dissipate energy.
KW  - electromyography
KW  - locomotion
KW  - overload
KW  - stretch-shortening cycle
KW  - ultrasound
Y1  - 2023
U6  - https://doi.org/10.1152/japplphysiol.00279.2022
SN  - 1522-1601 (Onlineausgabe)
SN  - 8750-7587 (Druckausgabe)
VL  - 134
IS  - 1
SP  - 190
EP  - 202
PB  - American Physiological Society
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Neumaier, Felix
A1  - Weiss, Miriam
A1  - Veldeman, Michael
A1  - Kotliar, Konstantin
A1  - Wiesmann, Martin
A1  - Schulze-Steinen, Henna
A1  - Höllig, Anke
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
A1  - Albanna, Walid
T1  - Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage – preliminary findings from an observational cohort study
JF  - Clinical Neurology and Neurosurgery
N2  - Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.
KW  - constructive alignment
KW  - examination
KW  - long-term retention
KW  - multimodal
KW  - practical learning
Y1  - 2021
U6  - https://doi.org/10.1016/j.clineuro.2021.106870
SN  - 0303-8467
VL  - 208
IS  - Article No.: 106870
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Vögele, Stefan
A1  - Grajewski, Matthias
A1  - Govorukha, Kristina
A1  - Rübbelke, Dirk
T1  - Challenges for the European steel industry: Analysis, possible consequences and impacts on sustainable development
JF  - Applied Energy
N2  - The steel industry in the European Union (EU), important for the economy as a whole, faces various challenges. These are inter alia volatile prices for relevant input factors, uncertainties concerning the regulation of CO₂-emissions and market shocks caused by the recently introduced additional import duties in the US, which is an important sales market. We examine primary and secondary effects of these challenges on the steel industry in the EU and their impacts on European and global level. Developing and using a suitable meta-model, we analyze the competitiveness of key steel producing countries with respect to floor prices depending on selected cost factors and draw conclusions on the impacts in the trade of steel on emissions, energy demand, on the involvement of developing countries in the value chain as well on the need for innovations to avoid relocations of production. Hence, our study contributes to the assessment of sustainable industrial development, which is aimed by the Sustainability Development Goal “Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation countries”. By applying information on country-specific Human Development Indexes (reflecting aspects of life expectancy, education, and per capita income), we show that relocating energy-intensive industries from the EU may not only increase global energy demand and CO₂-emissions, but may also be to the disadvantage of developing countries.
Y1  - 2020
U6  - https://doi.org/10.1016/j.apenergy.2020.114633
SN  - 0306-2619
VL  - 264
IS  - Article number: 114633
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schubert, J.
A1  - Schöning, Michael Josef
A1  - Schmidt, C.
A1  - Siegert, M.
A1  - Mesters, S.
A1  - Zander, W.
A1  - Kordos, P.
A1  - Lüth, H.
A1  - Legin, A.
A1  - Mourzina, Y. G.
A1  - Seleznev, B.
A1  - Vlasov, Y. G.
T1  - Chalcogenide-based thin film sensors prepared by pulsed laser deposition technique
JF  - Applied Physics A. 69, (1999), H. Supplement 1
Y1  - 1999
SN  - 0947-8396
U6  - https://doi.org/10.1007/s003390051534
SP  - 803
EP  - 805
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Behr, M.
A1  - Arora, D.
A1  - Coronado, O.
A1  - Pasquali, M.
T1  - CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M.
JF  - Artificial Organs. 30 (2006), H. 11
Y1  - 2006
SN  - 1525-1594
N1  - Abstracts 14th Congress of the International Society for Rotary Blood Pumps, Leuven, Belgium, August 31–September 2, 2006 ; S7-4
SP  - A45
EP  - A46
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
A1  - Kelemen, C.
A1  - Porst, Dariusz
A1  - Büldt, G.
T1  - Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß über versteckte Materialeigenschaften zellulärer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; Büldt, G. ; Chien, Shu
JF  - Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1
Y1  - 1998
SN  - 1862-278
SP  - 446
EP  - 447
ER  - 
TY  - JOUR
A1  - Artmann, Gerhard
T1  - Cellular engineering - a challenge for engineers? / Artmann, G. M.
JF  - Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1
Y1  - 2000
SN  - 1862-278X
SP  - 449
ER  - 
TY  - CHAP
A1  - Schmidts, Oliver
A1  - Kraft, Bodo
A1  - Winkens, Marvin
A1  - Zündorf, Albert
T1  - Catalog integration of low-quality product data by attribute label ranking
T2  - Proceedings of the 9th International Conference on Data Science, Technology and Applications DATA - Volume 1
N2  - The integration of product data from heterogeneous sources and manufacturers into a single catalog is often still a laborious, manual task. Especially small- and medium-sized enterprises face the challenge of timely integrating the data their business relies on to have an up-to-date product catalog, due to format specifications, low quality of data and the requirement of expert knowledge. Additionally, modern approaches to simplify catalog integration demand experience in machine learning, word vectorization, or semantic similarity that such enterprises do not have. Furthermore, most approaches struggle with low-quality data. We propose Attribute Label Ranking (ALR), an easy to understand and simple to adapt learning approach. ALR leverages a model trained on real-world integration data to identify the best possible schema mapping of previously unknown, proprietary, tabular format into a standardized catalog schema. Our approach predicts multiple labels for every attribute of an inpu t column. The whole column is taken into consideration to rank among these labels. We evaluate ALR regarding the correctness of predictions and compare the results on real-world data to state-of-the-art approaches. Additionally, we report findings during experiments and limitations of our approach.
Y1  - 2020
SN  - 978-989-758-440-4
U6  - https://doi.org/10.5220/0009831000900101
N1  - 9th International Conference on Data Science, Technologies and Applications (DATA 2020), 7 - 9 July 2020, online
SP  - 90
EP  - 101
PB  - SciTePress
CY  - Setúbal, Portugal
ER  - 
TY  - CHAP
A1  - Schmidts, Oliver
A1  - Kraft, Bodo
A1  - Winkens, Marvin
A1  - Zündorf, Albert
T1  - Catalog integration of heterogeneous and volatile product data
T2  - DATA 2020: Data Management Technologies and Applications
N2  - The integration of frequently changing, volatile product data from different manufacturers into a single catalog is a significant challenge for small and medium-sized e-commerce companies. They rely on timely integrating product data to present them aggregated in an online shop without knowing format specifications, concept understanding of manufacturers, and data quality. Furthermore, format, concepts, and data quality may change at any time. Consequently, integrating product catalogs into a single standardized catalog is often a laborious manual task. Current strategies to streamline or automate catalog integration use techniques based on machine learning, word vectorization, or semantic similarity. However, most approaches struggle with low-quality or real-world data. We propose Attribute Label Ranking (ALR) as a recommendation engine to simplify the integration process of previously unknown, proprietary tabular format into a standardized catalog for practitioners. We evaluate ALR by focusing on the impact of different neural network architectures, language features, and semantic similarity. Additionally, we consider metrics for industrial application and present the impact of ALR in production and its limitations.
Y1  - 2021
SN  - 978-3-030-83013-7
U6  - https://doi.org/10.1007/978-3-030-83014-4_7
N1  - International Conference on Data Management Technologies and Applications, DATA 2020, 7-9 July
SP  - 134
EP  - 153
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Bäcker, Matthias
A1  - Zucolotto, Valtencir
A1  - Poghossian, Arshak
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 462
EP  - 467
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Scholl, Fabio
A1  - Morais, Paulo
A1  - Gabriel, Rayla
A1  - Schöning, Michael Josef
A1  - Siqueira, Jose Roberto, Jr.
A1  - Caseli, Luciano
T1  - Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications
JF  - Applied Materials & Interfaces
N2  - In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir–Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air–water interface was investigated by surface pressure–area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV–vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte–insulator–semiconductor (EIS) sensor device. The presence of CNTs in the enzyme–lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications.
Y1  - 2017
U6  - https://doi.org/10.1021/acsami.7b08095
SN  - 1944-8252
VL  - 9
IS  - 36
SP  - 31054
EP  - 31066
PB  - ACS
CY  - Washington
ER  - 
TY  - JOUR
A1  - Rodrigues, Raul T.
A1  - Morais, Paulo V.
A1  - Nordi, Cristina S. F.
A1  - Schöning, Michael Josef
A1  - Siqueira Jr., José R.
A1  - Caseli, Luciano
T1  - Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films
JF  - Langmuir
N2  - Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air–water interface were investigated by surface pressure–area isotherms, surface potential–area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte–insulator–semiconductor (EIS) devices, through the Langmuir–Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV–vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme–lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance–voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications.
Y1  - 2018
U6  - https://doi.org/10.1021/acs.langmuir.7b04317
SN  - 1520-5827
VL  - 34
IS  - 9
SP  - 3082
EP  - 3093
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Chaudhuri, S.
A1  - Zander, W.
A1  - Schubert, J.
A1  - Begoyan, V. K.
A1  - Buniatyan, V. V.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate
JF  - Sensors and actuators. B: Chemical
Y1  - 2014
U6  - https://doi.org/10.1016/j.snb.2014.02.103
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
IS  - 198
SP  - 102
EP  - 109
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Karschuck, Tobias
A1  - Poghossian, Arshak
A1  - Ser, Joey
A1  - Tsokolakyan, Astghik
A1  - Achtsnicht, Stefan
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage
JF  - Sensors and Actuators B: Chemical
N2  - Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed.
KW  - Field-effect biosensor
KW  - Capacitive model
KW  - Enzyme coverage
KW  - Multianalyte detection
KW  - Penicillin
Y1  - 2024
U6  - https://doi.org/10.1016/j.snb.2024.135530
SN  - 0925-4005 (Print)
SN  - 1873-3077 (Online)
N1  - Corresponding Author: Michael J. Schöning
VL  - 408
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Kurowski, A.
A1  - Thust, M.
A1  - Kordos, P.
A1  - Schultze, J. W.
A1  - Lüth, H.
T1  - Capacitive microsensors for biochemical sensing on porous silicon technology
JF  - Sensors and Actuators B. 64 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 59
EP  - 64
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Thust, M.
A1  - Kordos, P.
A1  - Schultze, J.W.
A1  - Lüth, H.
T1  - Capacitive microsensors for biochemical sensing based on porous silicon technology
JF  - Transducers '99 : proceedings of the Tenth International Conference on Solid-State Sensors and Actuators ; 7 - 10 June, 1999, Sendai, Japan / ed.: S. Middelhoek
Y1  - 2000
N1  - International Conference on Solid State Sensors and Actuators <10, 1999, Sendai, Miyagi-ken> ; Transducers '99 ; (10 : ; 1999.06.07-10 : ; Sendai)
SP  - 1184
EP  - 1187
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Münstermann, Felix
A1  - Nork, Jasmina
A1  - Molinnus, Denise
A1  - Muschallik, Lukas
A1  - Bongaerts, Johannes
A1  - Wagner, Torsten
A1  - Keusgen, Michael
A1  - Siegert, Petra
A1  - Schöning, Michael Josef
T1  - Capacitive field‐effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths
JF  - physica status solidi (a) applications and materials science
N2  - An acetoin biosensor based on a capacitive electrolyte–insulator–semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance–voltage, and constant capacitance methods, respectively.
KW  - acetoin
KW  - acetoin reductase
KW  - alcoholic beverages
KW  - biosensors
KW  - capacitive field-effect sensors
Y1  - 2021
U6  - https://doi.org/10.1002/pssa.202000765
SN  - 1862-6319
N1  - Corresponding author: Melanie Jablonski
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Buniatyan, Vahe V.
A1  - Matirosyan, N.
A1  - Abouzar, Maryam H.
A1  - Schubert, J.
A1  - Zander, W.
A1  - Gevorgian, S.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Capacitive field-effect pH sensor based on an electrolyte-ferroelectric-insulator-semiconductor structure
JF  - SENSOR 2009 : : 14th International Conference on Sensors, Technologies, Electronics and Applications; Nürnberg, Germany, 26 - 28 May 2009; proceedings; [part of] Sensor + Test Conference 2009 / AMA, Fachverband für Sensorik e.V
Y1  - 2009
SN  - 9783981099355
N1  - AMA, Fachverband für Sensorik ; Sensor International Conference ; (14 : ; 2009.05.26-28 : ; Nürnberg)
SP  - 317
EP  - 322
PB  - AMA Service
CY  - Wunstorf
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Capacitive field-effect eis chemical sensors and biosensors: A status report
JF  - Sensors
N2  - Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed.
Y1  - 2020
U6  - https://doi.org/10.3390/s20195639
SN  - 1424-8220
VL  - 20
IS  - 19
PB  - MDPI
CY  - Basel
ER  -