TY  - JOUR
A1  - Maggakis-Kelemen, C.
A1  - Bork, M.
A1  - Kayser, Peter
A1  - Biselli, Manfred
A1  - Artmann, Gerhard
T1  - Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells
JF  - Medical and biological engineering and computing. 41 (2003), H. 3
Y1  - 2003
SN  - 0140-0118
SP  - 350
EP  - 356
ER  - 
TY  - JOUR
A1  - Akimbekov, N. S.
A1  - Digel, Ilya
A1  - Tastambek, K. T.
A1  - Zhubanova, A. A.
T1  - Biocompatibility of carbonized rice husk with a rat heart cells line H9c2
JF  - Experimental Biology
Y1  - 2013
SN  - 1563-0218
N1  - Original in russischer Sprache
VL  - 59
IS  - 3/1
SP  - 23
EP  - 25
ER  - 
TY  - JOUR
A1  - Uysal, Karya
A1  - Creutz, Till
A1  - Firat, Ipek Seda
A1  - Artmann, Gerhard
A1  - Teusch, Nicole
A1  - Temiz Artmann, Aysegül
T1  - Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments
JF  - Polymers
N2  - Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3–4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.
Y1  - 2022
SN  - 2073-4360
VL  - 14
IS  - 11
SP  - 2213
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Mansurov, Z.
A1  - Digel, Ilya
A1  - Biisenbaev, M.
A1  - Savistkaya, I.
A1  - Kistaubaeva, A.
A1  - Akimbekov, N.
A1  - Zhubanova, A.
T1  - Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications
JF  - Eurasian Chemico-Technological Journal
Y1  - 2012
U6  - http://dx.doi.org/10.18321/ectj105
SN  - 2522-4867
VL  - 14
IS  - 2
SP  - 115
EP  - 131
PB  - Institute of Combustion Problems
CY  - Almaty
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Nishikawa, K.
A1  - Cook, M.
T1  - Bactericidal effects of plasma-generated cluster ions
JF  - Medical and Biological Engineering and Computing. 43 (2005), H. 6
Y1  - 2005
SN  - 1741-0444
SP  - 800
EP  - 807
ER  - 
TY  - JOUR
A1  - Digel, Ilya
A1  - Akimbekov, Nuraly
A1  - Rogachev, Evgeniy
A1  - Pogorelova, Natalia
T1  - Bacterial cellulose produced by Medusomyces gisevii on glucose and sucrose: biosynthesis and structural properties
JF  - Cellulose
N2  - In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy and X-ray diffraction. Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10 g L−1 after a 18–20 days incubation period. Glucose in general lead to a higher BC yield (173 g L−1) compared to sucrose (163.5 g L−1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.
KW  - Bacterial cellulose
KW  - Medusomyces gisevi
KW  - Carbon sources
KW  - Culture media
KW  - Cellulose nanostructure
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s10570-023-05592-z
SN  - 1572-882X (Online)
SN  - 0969-0239 (Print)
N1  - Corresponding author: Ilya Digel
PB  - Springer Science + Business Media
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Pogorelova, Natalia
A1  - Rogachev, Evgeniy
A1  - Digel, Ilya
A1  - Chernigova, Svetlana
A1  - Nardin, Dmitry
T1  - Bacterial Cellulose Nanocomposites: Morphology and Mechanical Properties
JF  - Materials
N2  - Bacterial cellulose (BC) is a promising material for biomedical applications due to its unique properties such as high mechanical strength and biocompatibility. This article describes the microbiological synthesis, modification, and characterization of the obtained BC-nanocomposites originating from symbiotic consortium Medusomyces gisevii. Two BC-modifications have been obtained: BC-Ag and BC-calcium phosphate (BC-Ca3(PO4)2). Structure and physicochemical properties of the BC and its modifications were investigated by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and infrared Fourier spectroscopy as well as by measurements of mechanical and water holding/absorbing capacities. Topographic analysis of the surface revealed multicomponent thick fibrils (150–160 nm in diameter and about 15 µm in length) constituted by 50–60 nm nanofibrils weaved into a left-hand helix. Distinctive features of Ca-phosphate-modified BC samples were (a) the presence of 500–700 nm entanglements and (b) inclusions of Ca3(PO4)2 crystals. The samples impregnated with Ag nanoparticles exhibited numerous roundish inclusions, about 110 nm in diameter. The boundaries between the organic and inorganic phases were very distinct in both cases. The Ag-modified samples also showed a prominent waving pattern in the packing of nanofibrils. The obtained BC gel films possessed water-holding capacity of about 62.35 g/g. However, the dried (to a constant mass) BC-films later exhibited a low water absorption capacity (3.82 g/g). It was found that decellularized BC samples had 2.4 times larger Young’s modulus and 2.2 times greater tensile strength as compared to dehydrated native BC films. We presume that this was caused by molecular compaction of the BC structure.
Y1  - 2020
SN  - 1996-1944
U6  - http://dx.doi.org/10.3390/ma13122849
VL  - 13
IS  - 12
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Behbahani, Mehdi
A1  - Spillner, Jan
A1  - Kopp, Rüdiger
A1  - Finocchiaro, Thomas
T1  - Assistierte Zirkulation : ein Überblick aus klinischer Sicht = Assisted circulation: an overview from a clinical perspective / Spillner, Jan ; Kopp, Rüdiger ; Finocchiaro, Thomas ; Behbahani, Mehdi ; Rossaint, Rolf ; Steinseifer, Ulrich ; Behr, Marek ; Au
JF  - Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5
Y1  - 2009
SN  - 0013-5585
N1  - Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471
SP  - 255
EP  - 267
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Albracht, Kirsten
A1  - Arampatzis, A.
A1  - Baltzopoulos, V.
T1  - Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo
JF  - Journal of Biomechanics
Y1  - 2008
U6  - http://dx.doi.org/10.1016/j.jbiomech.2008.04.020
SN  - 0021-9290
VL  - 41
SP  - 2211
EP  - 2218
ER  - 
TY  - JOUR
A1  - Ermolaev, AP
A1  - Erichev, VP
A1  - Antonov, AA
A1  - Grigoryan, GL
A1  - Kotliar, Konstantin
A1  - Levitsky, YV
A1  - Hderi, K
A1  - Mazurova, YV
T1  - Assessing retinal photosensitivity in patients with central vision impairment using a portable perimeter (a preliminary report)
JF  - Vestnik oftalmologii
Y1  - 2019
U6  - http://dx.doi.org/10.17116/oftalma201913503146
N1  - Abstract in Englisch
VL  - 135
IS  - 3
SP  - 46
EP  - 54
ER  - 
TY  - JOUR
A1  - Hunker, Jan L.
A1  - Gossmann, Matthias
A1  - Raman, Aravind Hariharan
A1  - Linder, Peter
T1  - Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility
JF  - Journal of Pharmacological and Toxicological Methods
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.vascn.2021.107044
SN  - 1056-8719
VL  - 111
IS  - Article number 107044
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Murgan, Ilina
A1  - Beyer, Sonja
A1  - Kotliar, Konstantin
A1  - Weber, Lutz
A1  - Bechtold-Dalla Pozza, Susanne
A1  - Dalla Pozza, Robert
A1  - Wegner, Aharon
A1  - Sitnikova, Diana
A1  - Stock, Konrad
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
A1  - Baumann, M.
T1  - Arterial and Retinal Vascular Changes in Hypertensive and Prehypertensive Adolescents
JF  - American Journal of Hypertension
Y1  - 2013
SN  - 1941-7225
VL  - 26
IS  - 3
SP  - 400
EP  - 408
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Savitskaya, I.S.
A1  - Kistaubayeva, A.S.
A1  - Ignatova, L.V.
A1  - Digel, Ilya
T1  - Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
JF  - Heliyon
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.heliyon.2019.e02592
SN  - 2405-8440
VL  - 5
IS  - 10
SP  - Artikelnummer e02592
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Levers, A.
A1  - Staat, Manfred
A1  - Laack, Walter van
T1  - Analysis of the long-term effect of the MBST® nuclear magnetic resonance therapy on gonarthrosis
JF  - Orthopedic Practice
Y1  - 2016
VL  - 47
IS  - 11
SP  - 521
EP  - 528
ER  - 
TY  - JOUR
A1  - Vu, Duc Khoi
A1  - Staat, Manfred
A1  - Tran, Ich Thinh
T1  - Analysis of pressure equipment by application of the primal-dual theory of shakedown
JF  - Communications in Numerical Methods in Engineering. 23 (2007), H. 3
Y1  - 2007
SN  - 1069-8299
SP  - 213
EP  - 225
ER  - 
TY  - JOUR
A1  - Levers, A.
A1  - Staat, Manfred
A1  - Laack, Walter van
T1  - Analyse der Langzeitwirkung der MBST® KernspinResonanzTherapie bei Gonarthrose
T1  - Analysis of the Long-term Effect of the MBST® Nuclear Magnetic Resonance Therapy on Gonarthrosis
N2  - Originalausgabe: Orthopädische Praxis Jg. 47. 2011 H. 11; S. 536-543. Mit freundlicher Genehmigung des Verlags Zusammenfassung: Auf der Basis von Patientenabfragen mittels Fragebogen zum Schmerzempfinden und zur Einschränkung bei Aktivitäten des alltäglichen Lebens wird die Langzeitwirkung der MBST® KernspinResonanz-Therapie bei Gonarthrose untersucht. An der Studie nahmen 39 Patienten teil, bei denen die Therapie bis zu vier Jahre zurückliegt. Neben einer Gesamtbetrachtung wird der Erfolg auch in Abhängigkeit von Alter, Geschlecht und sportlicher Aktivität analysiert. Insgesamt weist die Studie auf eine anhaltende Verbesserung des Gesundheitszustands mit zum Teil deutlicher Schmerzlinderung auch noch nach vier Jahren hin, jedoch mit einer leichten Schmerzzunahme gegen Ende des Untersuchungszeitraums von vier Jahren. Eine tendenziell positivere Wirkung bei Frauen, älteren Menschen oder auch sportlich nicht-aktiven Patienten lässt auf eine mögliche Beeinflussung des Erfolgs der Therapie durch (Über-)Belastung im Alltag schließen. Ein zusätzlich positiver Effekt der Therapie auf die Knochendichte ist ebenfalls denkbar, dies bleibt jedoch offen.
N2  - Original edition: Orthopädische Praxis Vol. 47. 2011 Issue 11; P. 536-543. On the friendly authority of the publisher. Abstract: Based upon a questionnaire for patient-queries regarding pain-sensation and activity-restrictions during everyday task, the long-term effect of MBST® nuclear magnetic resonance therapy is studied in osteoarthritis of the knee. 39 patients, whose therapy dates back up to four years, participated in the study. In addition to an overall view, the success of this therapy is also analyzed regarding age, gender and physical activities. Overall, the study pointed out a sustained improvement in the patients´ local health-status with a significant pain-relief even after four years, but also with a slight increase in pain towards the end of that four-year period. There tends to be more positive effect on women, on elderly of also on even non-sports-active patients which suggest a possible influence by daily (over)-stressing on the success of the therapy. An additional positive effect of the therapy on bone density is also conceivable, however, this remains open.
KW  - Kniegelenkarthrose
KW  - Gonarthrose
KW  - MBST
KW  - Arthosetherapie
KW  - gonarthrosis
KW  - MBST
KW  - arthrosis therapy
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Pham, Phu Tinh
A1  - Staat, Manfred
T1  - An Upper Bound Algorithm for Limit and Shakedown Analysis of Bounded Linearly Kinematic Hardening Structures
JF  - Limit State of Materials and Structures : Direct Methods 2. Saxcé, Géry de (Hrsg.)
Y1  - 2013
SN  - 978-94-007-5424-9
SP  - 71
EP  - 87
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Abel, Alexander
A1  - Kahmann, Stephanie Lucina
A1  - Mellon, Stephen
A1  - Staat, Manfred
A1  - Jung, Alexander
T1  - An open-source tool for the validation of finite element models using three-dimensional full-field measurements
JF  - Medical Engineering & Physics
N2  - Three-dimensional (3D) full-field measurements provide a comprehensive and accurate validation of finite element (FE) models. For the validation, the result of the model and measurements are compared based on two respective point-sets and this requires the point-sets to be registered in one coordinate system. Point-set registration is a non-convex optimization problem that has widely been solved by the ordinary iterative closest point algorithm. However, this approach necessitates a good initialization without which it easily returns a local optimum, i.e. an erroneous registration. The globally optimal iterative closest point (Go-ICP) algorithm has overcome this drawback and forms the basis for the presented open-source tool that can be used for the validation of FE models using 3D full-field measurements. The capability of the tool is demonstrated using an application example from the field of biomechanics. Methodological problems that arise in real-world data and the respective implemented solution approaches are discussed.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.medengphy.2019.10.015
SN  - 1350-4533
VL  - 77
SP  - 125
EP  - 129
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Kühn, R.
A1  - Hauger, W.
A1  - Sponagel, Stefan
T1  - An Interpretation of Wolff’s Law
JF  - Biomedizinische Technik. 49 (2004)
Y1  - 2004
SN  - 0932-4666
N1  - Ergänzungsband 2, Teil 2
SP  - 1020
EP  - 1021
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - An extension strain type Mohr–Coulomb criterion
JF  - Rock mechanics and rock engineering
N2  - Extension fractures are typical for the deformation under low or no confining pressure. They can be explained by a phenomenological extension strain failure criterion. In the past, a simple empirical criterion for fracture initiation in brittle rock has been developed. In this article, it is shown that the simple extension strain criterion makes unrealistic strength predictions in biaxial compression and tension. To overcome this major limitation, a new extension strain criterion is proposed by adding a weighted principal shear component to the simple criterion. The shear weight is chosen, such that the enriched extension strain criterion represents the same failure surface as the Mohr–Coulomb (MC) criterion. Thus, the MC criterion has been derived as an extension strain criterion predicting extension failure modes, which are unexpected in the classical understanding of the failure of cohesive-frictional materials. In progressive damage of rock, the most likely fracture direction is orthogonal to the maximum extension strain leading to dilatancy. The enriched extension strain criterion is proposed as a threshold surface for crack initiation CI and crack damage CD and as a failure surface at peak stress CP. Different from compressive loading, tensile loading requires only a limited number of critical cracks to cause failure. Therefore, for tensile stresses, the failure criteria must be modified somehow, possibly by a cut-off corresponding to the CI stress. Examples show that the enriched extension strain criterion predicts much lower volumes of damaged rock mass compared to the simple extension strain criterion.
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00603-021-02608-7
SN  - 1434-453X
N1  - Corresponding author: Manfred Staat
VL  - 54
IS  - 12
SP  - 6207
EP  - 6233
PB  - Springer Nature
CY  - Cham
ER  -