TY  - JOUR
A1  - Kuchler, Timon
A1  - Günthner, Roman
A1  - Ribeiro, Andrea
A1  - Hausinger, Renate
A1  - Streese, Lukas
A1  - Wöhnl, Anna
A1  - Kesseler, Veronika
A1  - Negele, Johanna
A1  - Assali, Tarek
A1  - Carbajo-Lozoya, Javier
A1  - Lech, Maciej
A1  - Adorjan, Kristina
A1  - Stubbe, Hans Christian
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Haller, Berhard
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
T1  - Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
N2  - Background
Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians.

Methods
In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204).

Measurements and main results
PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42% ± 1.77% vs. 4.64% ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5–190.2] vs. 189.1 [179.4–197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8–0.9] vs. 0.88 [0.8–0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = − 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters.

Conclusion
Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.
KW  - Endothelial dysfunction
KW  - Long COVID
KW  - Post-COVID-19 syndrome
KW  - retinal microvasculature
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s10456-023-09885-6
N1  - Corresponding author: Christoph Schmaderer
VL  - 26
SP  - 547
EP  - 563
PB  - Springer Nature
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Amin, Rashid
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
A1  - Lazarovici, Philip
A1  - Lelkes, Peter I.
T1  - Permeability of an In Vitro Model of Blood Brain Barrier (BBB)
JF  - 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]
Y1  - 2009
SN  - 978-3-540-92841-6
N1  - IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3–6 December 2008 Singapore
SP  - 81
EP  - 84
ER  - 
TY  - CHAP
A1  - Savitskaya, Irina S.
A1  - Kistaubayeva, Aida S.
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Zhubanova, Azhar A.
T1  - Performance of Bio-Composite Carbonized Materials in Probiotic Applications
T2  - World Academy of Science, Engineering and Technology International Journal of Biotechnology and Bioengineering
Y1  - 2013
VL  - 7
IS  - 7
SP  - 685
EP  - 689
ER  - 
TY  - JOUR
A1  - Gutheil, Inge
A1  - Berg, Tommy
A1  - Grotendorst, Johannes
T1  - Performance Analysis of Parallel Eigensolvers of two Libraries on BlueGene/P
JF  - Journal of Mathematics and Systems Science
N2  - Many applications in computational science and engineering require the computation of eigenvalues and vectors of dense symmetric or Hermitian matrices. For example, in DFT (density functional theory) calculations on modern supercomputers 10% to 30% of the eigenvalues and eigenvectors of huge dense matrices have to be calculated. Therefore, performance and parallel scaling of the used eigensolvers is of upmost interest. In this article different routines of the linear algebra packages ScaLAPACK and Elemental for parallel solution of the symmetric eigenvalue problem are compared concerning their performance on the BlueGene/P supercomputer. Parameters for performance optimization are adjusted for the different data distribution methods used in the two libraries. It is found that for all test cases the new library Elemental which uses a two-dimensional element by element distribution of the matrices to the processors shows better performance than the old ScaLAPACK library which uses a block-cyclic distribution.
KW  - performance analysis
KW  - Elemental
KW  - ScaLAPACK
KW  - eigensolvers
KW  - Numerical linear algebra
Y1  - 2012
U6  - http://dx.doi.org/10.17265/2159-5291/2012.04.003
SN  - 2159-5291
VL  - 2
IS  - 4
SP  - 231
EP  - 236
PB  - David Publishing
CY  - Libertyville
ER  - 
TY  - JOUR
A1  - Vant, Christianne
A1  - Staat, Manfred
A1  - Baroud, Gamal
T1  - Percutaneous Vertebroplasty: A Review of Two Intraoperative Complications
JF  - Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)
Y1  - 2008
SN  - 978-3-540-75408-4
SP  - 527
EP  - 539
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Razavi, Arash
A1  - Besmehn, Astrid
A1  - Bijnens, Nathalie
A1  - Williams, Oliver A.
A1  - Haenen, Ken
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Penicillin detection with nanocrystalline-diamond field-effect sensor
JF  - physica status solidi (a). 205 (2008), H. 9
Y1  - 2008
SN  - 1862-6319
N1  - Special Issue: Hasselt Diamond Workshop 2008 - SBDD XIII
SP  - 2141
EP  - 2145
ER  - 
TY  - JOUR
A1  - Koch, Claudia
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Wege, Christian
T1  - Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors
JF  - Nanotheranostics
N2  - The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.
Y1  - 2018
U6  - http://dx.doi.org/10.7150/ntno.22114
SN  - 2206-7418
VL  - 2
IS  - 2
SP  - 184
EP  - 196
PB  - Ivyspring
CY  - Sydney
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Thust, M.
A1  - Schroth, P.
A1  - Steffen, A.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of silicon-based field-effect structures
JF  - Sensors and Materials. 13 (2001), H. 4
Y1  - 2001
SN  - 0392-2510
SP  - 207
EP  - 223
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Sensors and Actuators B. 78 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 237
EP  - 242
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, T.
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]
Y1  - 2000
SN  - 87-89935-50-0
N1  - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen)
SP  - 27
EP  - 30
PB  - MIC, Mikroelektronik Centret
CY  - Lyngby, Denmark
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer
JF  - Biosensors and Bioelectronics. 25 (2009), H. 2
Y1  - 2009
SN  - 0956-5663
SP  - 497
EP  - 501
ER  - 
TY  - CHAP
A1  - Bhattarai, Aroj
A1  - Staat, Manfred
ED  - Fernandes, P.R.
ED  - Tavares, J. M.
T1  - Pectopexy to repair vaginal vault prolapse: a finite element approach
T2  - Proceedings CMBBE 2018
N2  - The vaginal prolapse after hysterectomy (removal of the uterus) is often associated with the prolapse of the vaginal vault, rectum, bladder, urethra or small bowel. Minimally
invasive surgery such as laparoscopic sacrocolpopexy and pectopexy are widely performed for the treatment of the vaginal prolapse with weakly supported vaginal vault after hysterectomy using prosthetic mesh implants to support (or strengthen) lax apical ligaments. Implants of different shape, size and polymers are selected depending on the patient’s anatomy and the surgeon’s preference. In this computational study on pectopexy, DynaMesh®-PRP soft, GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® soft and Ultrapro® are tested in a 3D finite element model of the female pelvic floor. The mesh model is implanted into the extraperitoneal space and sutured to the vaginal stump with a bilateral fixation to the iliopectineal ligament at both sides. Numerical simulations are conducted at rest, after surgery and during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues and prosthetic meshes are modeled as incompressible, isotropic hyperelastic materials. The positions of the organs are calculated with respect to the pubococcygeal line (PCL) for female pelvic floor at rest, after repair and during Valsalva maneuver using the three meshes.
Y1  - 2018
N1  - 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization. CMBBE 2018. 26-29 March 2018, Lisbon, Portugal
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
A1  - Ramakrishna, S.
T1  - PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation / X. Mo, H.-J. Weber, S. Ramakrishna
JF  - The International journal of artificial organs. 29 (2006), H. 8
Y1  - 2006
SP  - 790
EP  - 799
PB  - -
ER  - 
TY  - JOUR
A1  - Faßbender, F.
A1  - Schmitt, G.
A1  - Schöning, Michael Josef
A1  - Lüth, H.
A1  - Buß, G.
A1  - Schultze, J. W.
T1  - Passivation and corrosion of microsensor devices exemplified at microelectrode arrays
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague)
SP  - 953
EP  - 956
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Schmitt, G.
A1  - Schultze, J.-W.
A1  - Faßbender, F.
A1  - Buß, G.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Passivation and corrosion of microelectrode arrays
JF  - Electrochimica Acta. 44 (1999), H. 21-22
Y1  - 1999
SN  - 0013-4686
SP  - 3865
EP  - 3883
ER  - 
TY  - JOUR
A1  - Schmitt, G.
A1  - Faßbender, F.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
A1  - Schultze, J. W.
A1  - Buß, G.
T1  - Passivation and corrosion of microelectrode arrays
JF  - Materials and Corrosion. 51 (2000), H. 1
Y1  - 2000
SN  - 0947-5117
SP  - 20
EP  - 25
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Gono, Y.
A1  - Lieder, R. M.
A1  - Neskakis, A.
T1  - Particle-hole symmetry observed in the angular distributions of γ-rays in ¹⁸⁹,¹⁹¹,¹⁹³ Au
JF  - Physics letters / B. 70 (1977), H. 2
Y1  - 1977
SN  - 0031-9163
SP  - 159
EP  - 162
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Gono, Y.
A1  - Lieder, R. M.
A1  - Neskakis, A.
T1  - Particle-hole symmetry observed in the angular distributions of γ-rays in ¹⁸⁹,¹⁹¹,¹⁹³ Au
JF  - Annual report 1977 / Institut für Kernphysik Kernforschungsanlage Jülich
Y1  - 1978
N1  - Spezielle Berichte der Kernforschungsanlage Jülich ; 15
SP  - 45
EP  - 46
PB  - Verlag des Forschungszentrums Jülich
CY  - Jülich
ER  - 
TY  - JOUR
A1  - Müller-Veggian, Mattea
A1  - Beuscher, H.
A1  - Gono, Y.
A1  - Lieder, R. M.
T1  - Particle and collective properties of high spin states in heavy nuclei near z=82
JF  - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft (1977)
Y1  - 1977
SP  - 985
ER  - 
TY  - JOUR
A1  - Sponagel, Stefan
A1  - Baroud, G.
A1  - Steffen, T.
A1  - Wu, J.
T1  - Parameter identification for cement infiltration of osteoporotic bone
JF  - Poromechanics II : Proceedings of the Second Biot Conference on Poromechanics Grenoble, France 26 - 28 August 2002 / ed. by J.-L. Auriault ...
Y1  - 2002
SN  - 90-5809-394-8
SP  - 55
EP  - 58
PB  - Balkema
CY  - Lisse [u.a.]
ER  -