TY - CHAP A1 - Kroll-Ludwigs, Kathrin ED - Oetker, Hartmut ED - Rixecker, Roland ED - Säcker, Jürgen T1 - Kommentierung zu §§ 1802 - 1834 T2 - Münchener Kommentar zum BGB Band 9, Familienrecht II Y1 - 2017 SN - 978-3-406-66548-6 PB - C.H.Beck CY - München ET - 7. Auflage ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Kommentierung zu §§ 1837 - 1851 T2 - Münchener Kommentar zum BGB Band 9, Familienrecht II Y1 - 2017 SN - 978-3-406-66548-6 PB - C.H.Beck CY - München ET - 7. Auflage ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Kommentierung zu §§ 1852 - 1857a T2 - Münchener Kommentar zum BGB Band 9, Familienrecht II Y1 - 2017 SN - 978-3-406-66548-6 PB - C.H.Beck CY - München ET - 7. Auflage ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin ED - Weller, Marc-Philippe ED - Kindler, Peter T1 - Art. 48 EGBGB: Wahl eines in einem anderen Mitgliedstaat der Europäischen Union erworbenen Namens, Rn. 5-8, Rn. 11-14, Rn. 45-47, Rn. 48-51 T2 - Beck‘scher Online-Großkommentar zum Bürgerlichen Recht (BeckOGK), Band: Internationales Privatrecht Y1 - 2017 PB - C.H.Beck CY - München ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Names of individuals T2 - European Encyclopedia of Private International Law Y1 - 2017 SN - 9781782547228 PB - Edward Elgar Publishing CY - Cheltenham, UK ER - TY - CHAP A1 - Kroll-Ludwigs, Kathrin T1 - Small Claims Regulation T2 - European Encyclopedia of Private International Law Y1 - 2017 SN - 9781782547228 PB - Edward Elgar Publishing CY - Cheltenham, UK ER - TY - CHAP A1 - Samuelsson, K. A1 - Scheer, Nico A1 - Wilson, I. A1 - Wolf, C.R. A1 - Henderson, C.J. ED - Chackalamannil, Samuel T1 - Genetically Humanized Animal Models T2 - Comprehensive Medicinal Chemistry III. 3rd Edition N2 - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development. KW - Chimeric liver-humanized mice KW - Drug distribution KW - Drug metabolism KW - Toxicology KW - Knockout mice Y1 - 2017 SN - 978-0-12-803201-5 U6 - http://dx.doi.org/10.1016/B978-0-12-409547-2.12376-5 SP - 130 EP - 149 PB - Elsevier CY - Saint Louis ER - TY - CHAP A1 - Finkenberger, Isabel Maria A1 - Baumeister, Eva-Maria ED - Berger, Hilke Marit ED - Ziemer, Gesa T1 - Working in between : Die Stadt von der anderen Seite sehen : Where Urban Planning Meets Artistic Practice T2 - New Stakeholders of Urban Change : A Question of Culture and Attitude?. - (Perspectives in Metropolitan Research ; IV) Y1 - 2017 SN - 978-3-86859-487-4 SP - 119 EP - 129 PB - JOVIS Verlag CY - Berlin ER - TY - CHAP A1 - Altherr, Lena A1 - Dörig, Bastian A1 - Ederer, Thorsten A1 - Pelz, Peter Franz A1 - Pfetsch, Marc A1 - Wolf, Jan T1 - A mixed-integer nonlinear program for the design of gearboxes T2 - Operations Research Proceedings 2016 N2 - Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution. Y1 - 2017 SN - 978-3-319-55701-4 U6 - http://dx.doi.org/10.1007/978-3-319-55702-1_31 SP - 227 EP - 233 PB - Springer CY - Cham ER - TY - CHAP A1 - Fabo, Sabine T1 - Künstlerische Interventionen im öffentlichen Raum T2 - Die Experimentalstadt : Kreativität und die kulturelle Dimension der Nachhaltigen Entwicklung / Julia-Lena Reinermann, Friederike Behr (Hrsg.) N2 - Künstlerische Einlassungen auf den öffentlichen Raum folgten lange Zeit dem Prinzip des subkulturellen Widerstands. Nur in dem strategischen, invasiven Akt der Intervention sah man noch die Möglichkeit einer weitgreifenden Kritik am kulturellen System. Begriffe wie Cultural Hacking, Guerilla Marketing, Adbusting, Konsumguerilla oder parasitäre Strategien prägten eine rebellische Auffassung der künstlerischen Einmischung. Gleichzeitig konnten diese Haltungen aufgrund ihres rebellischen Chics mühelos von dem, was sie kritisierten, aufgenommen und vereinnahmt werden. Künstlerisches Handeln verharrt jedoch nicht in der Pose des Widerständigen, sondern arbeitet kontinuierlich an der Problematisierung und Gestaltung der öffentlichen Wahrnehmung. Viele Interventionen der Gegenwartskunst weisen unterschiedliche Grade der Ästhetisierung, der Partizipation und der Kooperation in der Auseinandersetzung mit dem öffentlichen Raum auf. Das wache Agieren im urbanen Kontext, die Irritation von Erwartungshaltungen, Fake und Desillusionierungsarbeit verstehen sich als künstlerische Arbeit an der Sensibilisierung der Wahrnehmung. KW - Künstlerische Intervention KW - Hacking KW - Parasitäre Strategie KW - Konsumkritik KW - Fake Y1 - 2017 SN - 978-3-658-14980-2 (Print) SN - 978-3-658-14981-9 (E-Book) SP - 201 EP - 217 PB - Springer Fachmedien CY - Wiesbaden ER - TY - CHAP A1 - Fabo, Sabine T1 - Das Dokumentarische als offene Konstruktion T2 - Doris Frohnapfel, Documentary derivative Y1 - 2017 SN - 978-3-942040-03-7 N1 - Diese Publikation erscheint anlässlich: Doris Frohnapfel, Documentary Derivative, COFA Contemporary 2016, 17.-20.11.2016, Halle 11.2, Stand B 028, Köln SP - 5 EP - 23 PB - Totalverlag CY - Köln ER - TY - CHAP A1 - Steuer-Dankert, Linda A1 - Bouffier, Anna A1 - Gaedicke, Sonja A1 - Leicht-Scholten, Carmen T1 - Diversifying engineering education: a transdisciplinary approach from RWTH Aachen University T2 - Strategies for increasing diversity in engineering majors and careers N2 - Engineers and therefore engineering education are challenged by the increasing complexity of questions to be answered globally. The education of future engineers therefore has to answer with curriculums that build up relevant skills. This chapter will give an example how to bring engineering and social responsibility successful together to build engineers of tomorrow. Through the integration of gender and diversity perspectives, engineering research and teaching is expanded with new perspectives and contents providing an important potential for innovation. Aiming on the enhancement of engineering education with distinctive competencies beyond technical expertise, the teaching approach introduced in the chapter represents key factors to ensure that coming generations of engineers will be able to meet the requirements and challenges a changing globalized world holds for them. The chapter will describe how this approach successfully has been implemented in the curriculum in engineering of a leading technical university in Germany. Y1 - 2017 SN - 9781522522126 U6 - http://dx.doi.org/10.4018/978-1-5225-2212-6.ch010 SP - 201 EP - 235 PB - IGI Global CY - Hershey, USA ER - TY - CHAP A1 - Dachwald, Bernd ED - Knopf, George K. ED - Otani, Yukitoshi T1 - Light propulsion systems for spacecraft T2 - Optical nano and micro actuator technology Y1 - 2017 SN - 9781315217628 (eBook) SP - 577 EP - 598 PB - CRC Press CY - Boca Raton ER - TY - CHAP A1 - Butenweg, Christoph T1 - Passt, wackelt und hat Luft: Mauerwerksbauten aus Leichtbeton in Erdbebengebieten T2 - Beton-Bauteile, 65. Ausgabe (2017): Entwerfen - Planen - Ausführen Y1 - 2017 SN - 978-3-7625-3676-5 N1 - gedruckt in der Bereichsbibliothek Bayernallee unter der Signatur 11 XCF 81-2017 vorhanden SP - 136 EP - 140 PB - Bauverl. CY - Gütersloh ER - TY - CHAP A1 - Pielen, Michael A1 - Röth, Thilo A1 - Flatten, T. ED - Proff, H. T1 - Erfolgsfaktoren künftiger Geschäftsmodelle von urbanen, geteilten Mobilitätsdienstleistungen T2 - Mobilität und digitale Transformation. (9. Wissenschaftsforum Mobilität. Tagungsband) N2 - Digitalisierung bezeichnet die Nutzung großer Datenmengen, die zu einer umfassenden Vernetzung aller Bereiche der Wirtschaft und Gesellschaft führen wird (BMWi, 2015 und ähnlich Köhler/Wollschläger, 2014: 79). Sie umfasst die Erhebung von analogen Informationen („Big Data“ in einem engen Sinne; z.B. O´Leary, 2013), ihre Speicherung in einem digitaltechnischen System (lokale Speicherung oder „Cloud Computing“ durch die Weiterentwickelung des Internets; z.B. Hashem et al., 2015: 101), die Analyse und Interpretation sowie den Transfer in andere Systeme („Internet der Dinge“ bzw. „Internet of Things“; z.B. Ashton, 2009). Y1 - 2018 SN - 978-3-658-20779-3 U6 - http://dx.doi.org/10.1007/978-3-658-20779-3_2 SP - 435 EP - 448 PB - Springer Gabler CY - Wiesbaden ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Frotscher, Ralf A1 - Staat, Manfred T1 - Computational Analysis of Pelvic Floor Dysfunction T2 - Women's Health and Biomechanics N2 - Pelvic floor dysfunction (PFD) is characterized by the failure of the levator ani (LA) muscle to maintain the pelvic hiatus, resulting in the descent of the pelvic organs below the pubococcygeal line. This chapter adopts the modified Humphrey material model to consider the effect of the muscle fiber on passive stretching of the LA muscle. The deformation of the LA muscle subjected to intra-abdominal pressure during Valsalva maneuver is compared with the magnetic resonance imaging (MRI) examination of a nulliparous female. Numerical result shows that the fiber-based Humphrey model simulates the muscle behavior better than isotropic constitutive models. Greater posterior movement of the LA muscle widens the levator hiatus due to lack of support from the anococcygeal ligament and the perineal structure as a consequence of birth-related injury and aging. Old and multiparous females with uncontrolled urogenital and rectal hiatus tend to develop PFDs such as prolapse and incontinence. KW - Pelvic muscle KW - Muscle fibers KW - Passive stretching KW - Pelvic floor dysfunction Y1 - 2018 SN - 978-3-319-71574-2 U6 - http://dx.doi.org/10.1007/978-3-319-71574-2_17 N1 - Lecture Notes in Computational Vision and Biomechanics, vol 29 SP - 217 EP - 230 PB - Springer CY - Cham ER - TY - CHAP A1 - Chwallek, Constanze A1 - Gölzer, Kaan A1 - Reichert, Walter T1 - Faymonville – Wachstum als Komplexitätstreiber T2 - Fallstudienkompendium Hidden Champions - Innovationen für den Weltmarkt N2 - Die Fallstudie FAYMONVILLE beschäftigt sich damit, wie es dem Familienunternehmen Faymonville aus Ostbelgien gelungen ist, sich zu einem der führenden Hersteller in seiner Branche zu entwickeln. Die gezielte Identifizierung neuer Märkte, die Fokussierung auf die relevanten Kundenbedürfnisse und eine konsistente Produktpolitik mit einem abgestimmten Fertigungskonzept legen die Grundsteine für den Erfolg. Das vorliegende Fallbeispiel zeigt anschaulich, wie es gelingen kann, den prinzipiellen Widerspruch zwischen wirtschaftlicher und kundenindividueller Fertigung erfolgreich aufzulösen. Y1 - 2018 SN - 978-3-658-17829-1 U6 - http://dx.doi.org/10.1007/978-3-658-17829-1_18 SP - 299 EP - 312 PB - Springer Gabler ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Mechanics of soft tissue reactions to textile mesh implants T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_11 SP - 251 EP - 275 PB - Springer CY - Singapore ER - TY - CHAP A1 - Artmann, Gerhard A1 - Meruvu, Haritha A1 - Kizildag, Sefa A1 - Temiz Artmann, Aysegül ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative “CellDrum technology” was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology. Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_7 SP - 157 EP - 192 PB - Springer CY - Singapore ER - TY - CHAP A1 - Duong, Minh Tuan A1 - Seifarth, Volker A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard A1 - Staat, Manfred ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries. KW - Mechanical simulation KW - Growth modelling KW - Ureter KW - Bladder KW - Reconstruction Y1 - 2018 SN - 978-981-10-7904-7 U6 - http://dx.doi.org/10.1007/978-981-10-7904-7_9 SP - 209 EP - 232 PB - Springer CY - Singapore ER -