TY  - JOUR
A1  - Tran, Linda
A1  - Mottaghy, K.
A1  - Arlt-Körfer, Sabine
A1  - Waluga, Christian
A1  - Behbahani, Mehdi
T1  - An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system
JF  - Biomedizinische Technik
Y1  - 2017
U6  - https://doi.org/10.1515/bmt-2015-0034
SN  - 0013-5585
VL  - 62
IS  - 4
SP  - 383
EP  - 392
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Gomes, Vanderley F., Jr.
A1  - Silva, Anielle C. A.
A1  - Dantas, Noelio O.
A1  - Schöning, Michael Josef
A1  - Siqueira, José R., Jr.
T1  - Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices
JF  - Journal of Materials Science
N2  - The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance–voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film’s surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications.
Y1  - 2017
U6  - https://doi.org/10.1007/s10853-017-1369-y
SN  - 1573-4803
VL  - 52
IS  - 20
SP  - 12314
EP  - 12325
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Röhlen, Desiree
A1  - Pilas, Johanna
A1  - Schöning, Michael Josef
A1  - Selmer, Thorsten
T1  - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid
JF  - Applied Biochemistry and Biotechnology
N2  - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates.
Y1  - 2017
U6  - https://doi.org/10.1007/s12010-017-2578-1
SN  - 1559-0291
VL  - 183
SP  - 566
EP  - 581
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Yazici, Yasemen
A1  - Selmer, Thorsten
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Optimization of an amperometric biosensor array for simultaneous measurement of ethanol, formate, d- and l-lactate
JF  - Electrochimica Acta
N2  - The immobilization of NAD+-dependent dehydrogenases, in combination with a diaphorase, enables the facile development of multiparametric sensing devices. In this work, an amperometric biosensor array for simultaneous determination of ethanol, formate, d- and l-lactate is presented. Enzyme immobilization on platinum thin-film electrodes was realized by chemical cross-linking with glutaraldehyde. The optimization of the sensor performance was investigated with regard to enzyme loading, glutaraldehyde concentration, pH, cofactor concentration and temperature. Under optimal working conditions (potassium phosphate buffer with pH 7.5, 2.5 mmol L-1 NAD+, 2.0 mmol L-1 ferricyanide, 25 °C and 0.4% glutaraldehyde) the linear working range and sensitivity of the four sensor elements was improved. Simultaneous and cross-talk free measurements of four different metabolic parameters were performed successfully. The reliable analytical performance of the biosensor array was demonstrated by application in a clarified sample of inoculum sludge. Thereby, a promising approach for on-site monitoring of fermentation processes is provided.
KW  - Simultaneous determination
KW  - Enzymatic biosensor
KW  - Diaphorase
KW  - Dehydrogenase
Y1  - 2017
U6  - https://doi.org/10.1016/j.electacta.2017.07.119
SN  - 0013-4686
VL  - 251
SP  - 256
EP  - 262
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lueke, Jan Niklas
A1  - Sjapic, Volha
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Sjapic, Sergej
A1  - Alpdogan, Serdan
A1  - Schneider, Toni
A1  - Schubert, Gerrit Alexander
A1  - Neumaier, Felix
T1  - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina
JF  - Current Eye Research
Y1  - 2017
U6  - https://doi.org/10.1080/02713683.2017.1339807
SN  - 1460-2202
IS  - Article in press
SP  - 1
EP  - 9
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Rietsch, Stefan H. G.
A1  - Pfaffenrot, Viktor
A1  - Bitz, Andreas
A1  - Orzada, Stephan
A1  - Brunheim, Sascha
A1  - Lazik-Palm, Andrea
A1  - Theysohn, Jens M.
A1  - Ladd, Mark E.
A1  - Quick, Harald H.
A1  - Kraff, Oliver
T1  - An 8-channel transceiver 7-channel receive RF coil setup for high SNR ultrahigh-field MRI of the shoulder at 7T
JF  - Medical Physics
Y1  - 2017
U6  - https://doi.org/10.1002/mp.12612
SN  - 0094-2405
IS  - Article in press
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hauser, Christine
A1  - Ortner, Marion
A1  - Muggenthaler, Claudia
A1  - Diehl-Schmid, Janine
A1  - Angermann, Susanne
A1  - Hapfelmeier, Alexander
A1  - Schmaderer, Christoph
A1  - Grimmer, Timo
T1  - Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
JF  - Scientific Reports
Y1  - 2017
U6  - https://doi.org/10.1038/s41598-017-13349-5
SN  - 2045-2322
N1  - Article 12906
VL  - 7
IS  - 1
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Investigation of the spatial resolution of a laser-based stimulation process for light-addressable hydrogels with incorporated graphene oxide by means of IR thermography
JF  - Sensors and Actuators A: Physical
Y1  - 2017
U6  - https://doi.org/10.1016/j.sna.2017.11.031
SN  - 0924-4247
VL  - 268
SP  - 126
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Demmer, Julius K.
A1  - Chowdhury, Nilanjan Pal
A1  - Selmer, Thorsten
A1  - Ermler, Ulrich
A1  - Buckel, Wolfgang
T1  - The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
JF  - Nature Communications
Y1  - 2017
U6  - https://doi.org/10.1038/s41467-017-01746-3
SN  - 2041-1723
N1  - Article number 1577
VL  - 8
IS  - 1
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J.
A1  - Meier, Rahel
A1  - Mojsen-Moeller, Jens
A1  - Seynnes, Olivier R.
T1  - Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task
JF  - Journal of Experimental Biology
Y1  - 2017
U6  - https://doi.org/10.1242/jeb.164111
SN  - 0022-0949
VL  - 220
IS  - 22
SP  - 4141
EP  - 4149
ER  - 
TY  - JOUR
A1  - Höttges, Jörg
T1  - QKan - Management of drainage system data with QGIS
JF  - Free and Open Source Software for Geospatial (FOSS4G) Conference Proceedings
Y1  - 2017
VL  - 17
IS  - Article 13
SP  - 95
EP  - 100
ER  - 
TY  - JOUR
A1  - Srivastava, A.
A1  - Chahar, V.
A1  - Sharma, V.
A1  - Sun, Y.
A1  - Bol, R.
A1  - Knolle, F.
A1  - Schnug, E.
A1  - Hoyler, Friedrich
A1  - Naskar, N.
A1  - Lahiri, S.
A1  - Patnaik, R.
T1  - Study of uranium toxicity using low-background gamma-ray spectrometry
JF  - Journal of Radioanalytical and Nuclear Chemistry
Y1  - 2017
U6  - https://doi.org/10.1007/s10967-017-5466-9
SN  - 1588-2780
IS  - Online first
SP  - 1
EP  - 7
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Garibaldi, F.
A1  - Beging, Stefan
A1  - Canese, R.
A1  - Carpinelli, G.
A1  - Clinthorne, N.
A1  - Colilli, S.
A1  - Cosentino, L.
A1  - Finocchiaro, P.
A1  - Giuliani, F.
A1  - Gricia, M.
A1  - Lucentini, M.
A1  - Majewski, S.
A1  - Monno, E.
A1  - Musico, P.
A1  - Santavenere, F.
A1  - Tödter, J.
A1  - Wegener, Hans-Peter
A1  - Ziemons, Karl
T1  - A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer
JF  - European Physical Journal Plus
Y1  - 2017
U6  - https://doi.org/10.1140/epjp/i2017-11662-x
SN  - 2190-5444
VL  - 132
IS  - 9
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Weber, Tobias
A1  - Ruff-Stahl, Hans-Joachim K.
T1  - Advances in Composite Manufacturing of Helicopter Parts
JF  - International Journal of Aviation, Aeronautics, and Aerospace
Y1  - 2017
U6  - https://doi.org/10.15394/ijaaa.2017.1153
SN  - 2374-6793
VL  - 4
IS  - 1
ER  - 
TY  - JOUR
A1  - Müller, Wolfram
A1  - Jung, Alexander
A1  - Ahammer, Helmut
T1  - Advantages and problems of nonlinear methods applied to analyze physiological time signals: human balance control as an example
JF  - Scientific Reports
Y1  - 2017
SN  - 2045-2322
U6  - https://doi.org/10.1038/s41598-017-02665-5
VL  - 7
IS  - Article number 2464
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Meyer, Jan
A1  - Hentschke, Reinhard
A1  - Hager, Jonathan
A1  - Hojdis, Nils
A1  - Karimi-Varzaneh, Hossein Ali
T1  - Molecular Simulation of Viscous Dissipation due to Cyclic Deformation of a Silica–Silica Contact in Filled Rubber
JF  - Macromolecules
Y1  - 2017
U6  - https://doi.org/10.1021/acs.macromol.7b00947
SN  - 1520-5835
VL  - 50
IS  - 17
SP  - 6679
EP  - 6689
ER  - 
TY  - JOUR
A1  - Mayer, Jan
A1  - Hentschke, Reinhard
A1  - Hager, Jonathan
A1  - Hojdis, Nils
A1  - Karimi-Varnaneh, Hossein Ali
T1  - A Nano-Mechanical Instability as Primary Contribution to Rolling Resistance
JF  - Scientific Reports
Y1  - 2017
SN  - 2045-2322
VL  - 7
IS  - Article number 11275
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Neu, Eugen
A1  - Janser, Frank
A1  - Khatibi, Akbar A.
A1  - Orifici, Adrian C.
T1  - Fully Automated Operational Modal Analysis using multi-stage clustering
JF  - Mechanical Systems and Signal Processing
Y1  - 2017
U6  - https://doi.org/10.1016/j.ymssp.2016.07.031
SN  - 0888-3270
VL  - Vol. 84, Part A
SP  - 308
EP  - 323
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Noureddine, Yacine
A1  - Kraff, Oliver
A1  - Ladd, Mark E.
A1  - Wrede, Karsten H.
A1  - Chen, Bixia
A1  - Quick, Harald H.
A1  - Schaefers, Gregor
A1  - Bitz, Andreas
T1  - In vitro and in silico assessment of RF-induced heating around intracranial aneurysm clips at 7 Tesla
JF  - Magnetic Resonance in Medicine
Y1  - 2017
U6  - https://doi.org/10.1002/mrm.26650
SN  - 1522-2594
IS  - Early view
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Zange, Jochen
A1  - Schopen, Kathrin
A1  - Albracht, Kirsten
A1  - Gerlach, Darius A.
A1  - Frings-Meuthen, Petra
A1  - Maffiuletti, Nicola A.
A1  - Bloch, Wilhelm
A1  - Rittweger, Jörn
T1  - Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial
JF  - Plos one
Y1  - 2017
U6  - https://doi.org/10.1371/journal.pone.0171562
VL  - 12
IS  - 2
ER  -