TY - CHAP A1 - Dachwald, Bernd A1 - Xu, Changsheng A1 - Feldmann, Marco A1 - Plescher, Engelbert A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Development and testing of a subsurface probe for detection of life in deep ice : [abstract] N2 - We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named “IceMole”, is currently developed, built, and tested at the FH Aachen University of Applied Sciences’ Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth). KW - Eisschicht KW - Sonde KW - subsurface probe KW - subsurface ice research Y1 - 2011 ER - TY - JOUR A1 - Digel, Ilya T1 - Primary thermosensory events in cells JF - Transient receptor potential channels / Md. Shahidul Islam, ed. Y1 - 2011 SN - 978-94-007-0264-6 N1 - (Advances in experimental medicine and biology ; 704) SP - 451 EP - 468 PB - Springer CY - Dordrecht [u.a.] ER - TY - JOUR A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - The emperor's new body : seeking for a blueprint of limb regeneration in humans JF - Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds. Y1 - 2011 SN - 978-3-642-11864-7 SP - 3 EP - 37 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Zhubanova, Azhar A. A1 - Aknazarov, S. K. A1 - Mansurov, Zulkhair A1 - Digel, Ilya A1 - Kozhalakova, A. A. A1 - Akimbekov, Nuraly Shardarbekovich A1 - O'Heras, Carlos A1 - Tazhibayeva, S. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials N2 - Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment. KW - Kohlenstofffaser KW - Lipopolysaccharide KW - nanostrukturierte carbonisierte Pflanzenteile KW - lipopolysaccharides KW - nanostructured carbonized plant parts Y1 - 2010 ER - TY - CHAP A1 - Kurulgan Demirci, Eylem A1 - Linder, Peter A1 - Demirci, Taylan A1 - Gierkowski, Jessica R. A1 - Digel, Ilya A1 - Gossmann, Matthias A1 - Temiz Artmann, Aysegül T1 - rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract] N2 - In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension. KW - Endothelzelle KW - Sepsis KW - kontraktile Spannung KW - rhAPC KW - contractile tension KW - rhAPC KW - celldrum technology Y1 - 2010 ER - TY - CHAP A1 - Artmann, Gerhard A1 - Stadler, Andreas M. A1 - Embs, Jan P. A1 - Zaccai, Giuseppe A1 - Büldt, Georg A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract] N2 - The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature KW - Hämoglobin KW - Erythrozyt KW - Körpertemperatur Y1 - 2010 ER - TY - CHAP A1 - Digel, Ilya A1 - Leimena, W. A1 - Dachwald, Bernd A1 - Linder, Peter A1 - Porst, Dariusz A1 - Kayser, Peter A1 - Funke, O. A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - In-situ biological decontamination of an ice melting probe : [abstract] N2 - The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting. KW - Sonde KW - Dekontamination KW - Wasserstoffperoxid KW - Natriumhypochlorit Y1 - 2010 ER - TY - JOUR A1 - Leimena, W. A1 - Artmann, Gerhard A1 - Dachwald, Bernd A1 - Temiz Artmann, Aysegül A1 - Gossmann, Matthias A1 - Digel, Ilya T1 - Feasibility of an in-situ microbial decontamination of an ice-melting probe JF - Eurasian Chemico-Technological Journal. 12 (2010), H. 2 Y1 - 2010 SN - 1562-3920 SP - 145 EP - 150 ER - TY - JOUR A1 - Akimbekov, N. Sh. A1 - Zhubanova, A. A. A1 - Mansurov, Z. A. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Use of Carbonized Rise Shell for the local treatment of wounds JF - Eurasian ChemTech Journal N2 - On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis. Y1 - 2010 U6 - http://dx.doi.org/10.18321/ectj35 SN - 2522-4867 VL - 12 IS - 2 SP - 133 EP - 138 PB - Institute of Combustion Problems CY - Almaty ER - TY - JOUR A1 - Kozhalakova, A. A. A1 - Zhubanova, Azhar A. A1 - Mansurov, Z. A. A1 - Digel, Ilya A1 - Tazhibayeva, S. M. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Adsorption of bacterial lipopolysaccharides on carbonized rice shell JF - Science of Central Asia (2010) Y1 - 2010 SP - 50 EP - 54 ER - TY - JOUR A1 - Digel, Ilya T1 - In-situ biological decontamination of an ice melting probe Y1 - 2010 N1 - 38th COSPAR Scientific Assembly. Held 18-15 July 2010, in Bremen, Germany Abstract unter https://www.cospar-assembly.org/abstractcd/OLD/COSPAR-10/abstracts/data/pdf/abstracts/F36-0013-10.pdf ER - TY - JOUR A1 - Kurz, R. A1 - Linder, Peter A1 - Trzewik, Jürgen A1 - Rüffer, M. A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Rothermel, A. A1 - Robitzki, A. A1 - Temiz Artmann, Aysegül T1 - Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes JF - Medical and Biological Engineering and Computing N2 - The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching. Y1 - 2010 U6 - http://dx.doi.org/10.1007/s11517-009-0552-y SN - 1741-0444 VL - 48 IS - 1 SP - 59 EP - 65 PB - Springer Nature CY - Cham ER - TY - CHAP A1 - Arinkin, Vladimir A1 - Digel, Ilya T1 - Water bridge phenomenon : [abstract] N2 - One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge" KW - Hydrodynamik KW - Elektrodynamik KW - Wasserbrücke KW - water bridge phenomenon Y1 - 2009 ER - TY - CHAP A1 - ElBashir, Rasha A1 - Digel, Ilya T1 - Effect of nitric oxide gas on hydrogels : [abstract] N2 - The results support our theory that the NO gas has an influence in increasing the translational diffusion of hydrogels and it accelerates the melting process of the gels. KW - Stickstoffmonoxid KW - Hydrogel KW - nitric oxide gas KW - hydrogel Y1 - 2009 ER - TY - CHAP A1 - O\'Heras, Carlos A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - Nanostructured carbon-based column for LPS/protein adsorption : [abstract] N2 - The absence of a general method for endotoxin removal from liquid interfaces gives an opportunity to find new methods and materials to overcome this gap. Activated nanostructured carbon is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study is to find the adsorption rates for a carboneous material produced at different temperatures, as well as to reveal possible differences between the performance of the material for each of the adsorbates used during the study (hemoglobin, serum albumin and lipopolysaccharide, LPS). KW - Kohlenstofffaser KW - Adsorption KW - Lipopolysaccharide KW - aktivierte nanostrukturierte Kohlenstofffaser KW - lipopolysaccharides KW - activated nanostructured carbon Y1 - 2009 ER - TY - CHAP A1 - Bassam, Rasha A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Effect of nitric oxide on protein thermal stability : [abstract] N2 - As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not. KW - Stickstoffmonoxid KW - Proteine KW - Hämoglobin KW - nitric oxide gas KW - protein KW - hemoglobin Y1 - 2009 ER - TY - CHAP A1 - Digel, Ilya A1 - Dachwald, Bernd A1 - Artmann, Gerhard A1 - Linder, Peter A1 - Funke, O. T1 - A concept of a probe for particle analysis and life detection in icy environments N2 - A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa’s ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live. KW - Sonde KW - Eisschicht KW - Autofluoreszenzverfahren KW - Lichtstreuungsbasierte Instrumente KW - autofluorescence-based detection system KW - light scattering analysis Y1 - 2009 ER - TY - JOUR A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Zerlin, Kay A1 - Maggakis-Kelemen, Christina A1 - Linder, Peter A1 - Porst, Dariusz A1 - Kayser, Peter A1 - Stadler, David A1 - Dikta, Gerhard A1 - Temiz Artmann, Aysegül T1 - Hemoglobin senses body temperature JF - European Biophysics Journal Y1 - 2009 SN - 0175-7571 VL - 38 IS - 5 SP - 589 EP - 600 ER - TY - JOUR A1 - Sadykov, Rustam A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Porst, Dariusz A1 - Linder, Peter A1 - Kayser, Peter A1 - Artmann, Gerhard A1 - Savitskaya, Irina A1 - Zhubanova, Azhar T1 - Oral lead exposure induces dysbacteriosis in rats JF - Journal of Occupational Health. 51 (2009) (2009), H. 1 Y1 - 2009 SN - 1348-9585 SP - 64 EP - 73 ER - TY - JOUR A1 - Demirci, Taylan A1 - Kurulgan Demirci, Eylem A1 - Trzewik, Jürgen A1 - Linder, Peter A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Sakizli, Meral A1 - Temiz Artmann, Aysegül T1 - Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress JF - IUBMB Life. 61 (2009), H. 3 Y1 - 2009 SN - 1521-6543 N1 - Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey SP - 311 EP - 312 PB - Wiley-VCH CY - Weinheim ER -