TY - CHAP A1 - Tamaldin, Noreffendy A1 - Mansor, Muhd Rizuan A1 - Mat Yamin, Ahmad Kamal A1 - Bin Abdollah, Mohd Fazli A1 - Esch, Thomas A1 - Tonoli, Andrea A1 - Reisinger, Karl Heinz A1 - Sprenger, Hanna A1 - Razuli, Hisham ED - Bin Abdollah, Mohd Fadzli ED - Amiruddin, Hilmi ED - Singh, Amrik Singh Phuman ED - Munir, Fudhail Abdul ED - Ibrahim, Asriana T1 - Development of UTeM United Future Fuel Design Training Center Under Erasmus+ United Program T2 - Proceedings of the 7th International Conference and Exhibition on Sustainable Energy and Advanced Materials (ICE-SEAM 2021), Melaka, Malaysia N2 - The industrial revolution IR4.0 era have driven many states of the art technologies to be introduced especially in the automotive industry. The rapid development of automotive industries in Europe have created wide industry gap between European Union (EU) and developing countries such as in South-East Asia (SEA). Indulging this situation, FH Joanneum, Austria together with European partners from FH Aachen, Germany and Politecnico Di Torino, Italy is taking initiative to close the gap utilizing the Erasmus+ United grant from EU. A consortium was founded to engage with automotive technology transfer using the European ramework to Malaysian, Indonesian and Thailand Higher Education Institutions (HEI) as well as automotive industries. This could be achieved by establishing Engineering Knowledge Transfer Unit (EKTU) in respective SEA institutions guided by the industry partners in their respective countries. This EKTU could offer updated, innovative, and high-quality training courses to increase graduate’s employability in higher education institutions and strengthen relations between HEI and the wider economic and social environment by addressing Universityindustry cooperation which is the regional priority for Asia. It is expected that, the Capacity Building Initiative would improve the quality of higher education and enhancing its relevance for the labor market and society in the SEA partners. The outcome of this project would greatly benefit the partners in strong and complementary partnership targeting the automotive industry and enhanced larger scale international cooperation between the European and SEA partners. It would also prepare the SEA HEI in sustainable partnership with Automotive industry in the region as a mean of income generation in the future. KW - Erasmus+ United KW - technology transfer KW - UTeM Engineering Knowledge Transfer Unit KW - Malaysian automotive industry Y1 - 2022 SN - 978-981-19-3178-9 SN - 978-981-19-3179-6 (E-Book) U6 - https://doi.org/10.1007/978-981-19-3179-6_50 SN - 2195-4356 N1 - 7th International Conference and Exhibition on Sustainable Energy and Advanced Material (ICE-SEAM 2021), Universiti Teknikal Malaysia Melaka (UTeM), Malaysia, in association with the Universitas Sebelas Maret (UNS), Indonesia, 23 November 2021 SP - 274 EP - 278 PB - Springer Nature CY - Singapore ER - TY - JOUR A1 - Herssens, Nolan A1 - Cowburn, James A1 - Albracht, Kirsten A1 - Braunstein, Bjoern A1 - Cazzola, Dario A1 - Colyer, Steffi A1 - Minetti, Alberto E. A1 - Pavei, Gaspare A1 - Rittweger, Jörn A1 - Weber, Tobias A1 - Green, David A. ED - Cattaneo, Luigi T1 - Movement in low gravity environments (MoLo) programme – the MoLo-L.O.O.P. study protocol JF - PLOS ONE / Public Library of Science N2 - Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity. Y1 - 2022 U6 - https://doi.org/10.1371/journal.pone.0278051 SN - 1932-6203 VL - 17 IS - 11 PB - Plos CY - San Francisco ER - TY - JOUR A1 - Coll-Perales, Baldomero A1 - Schulte-Tigges, Joschua A1 - Rondinone, Michele A1 - Gozalvez, Javier A1 - Reke, Michael A1 - Matheis, Dominik A1 - Walter, Thomas T1 - Prototyping and evaluation of infrastructure-assisted transition of control for cooperative automated vehicles JF - IEEE Transactions on Intelligent Transportation Systems N2 - Automated driving is now possible in diverse road and traffic conditions. However, there are still situations that automated vehicles cannot handle safely and efficiently. In this case, a Transition of Control (ToC) is necessary so that the driver takes control of the driving. Executing a ToC requires the driver to get full situation awareness of the driving environment. If the driver fails to get back the control in a limited time, a Minimum Risk Maneuver (MRM) is executed to bring the vehicle into a safe state (e.g., decelerating to full stop). The execution of ToCs requires some time and can cause traffic disruption and safety risks that increase if several vehicles execute ToCs/MRMs at similar times and in the same area. This study proposes to use novel C-ITS traffic management measures where the infrastructure exploits V2X communications to assist Connected and Automated Vehicles (CAVs) in the execution of ToCs. The infrastructure can suggest a spatial distribution of ToCs, and inform vehicles of the locations where they could execute a safe stop in case of MRM. This paper reports the first field operational tests that validate the feasibility and quantify the benefits of the proposed infrastructure-assisted ToC and MRM management. The paper also presents the CAV and roadside infrastructure prototypes implemented and used in the trials. The conducted field trials demonstrate that infrastructure-assisted traffic management solutions can reduce safety risks and traffic disruptions. KW - Automated driving KW - automated vehicles KW - connected automated vehicles KW - CAV KW - experimental evaluation Y1 - 2021 U6 - https://doi.org/10.1109/TITS.2021.3061085 SN - 1524-9050 (Print) SN - 1558-0016 (Online) VL - 23 IS - 7 SP - 6720 EP - 6736 PB - IEEE ER - TY - CHAP A1 - Fissabre, Anke A1 - Wilson, Ariane ED - Di Teodoro, Francesco P. ED - Ferretti, Emanuela ED - Frommel, Sabine ED - Schlimme, Hermann T1 - Hypotheses on the Tower of Monthoiron: A Built Design of Italian and Leonardian Inspiration in France T2 - Leonardo da Vinci: l’architettura / Léonard de Vinci : l’architecture Y1 - 2022 SN - 979-12-80956-00-2 N1 - Sprachen laut Verlagsangaben: Italienisch, Englisch, Französisch SP - 287 EP - 300 PB - Campisano Editore CY - Roma ER - TY - CHAP A1 - Chavez Bermudez, Victor Francisco A1 - Cruz Castanon, Victor Fernando A1 - Ruchay, Marco A1 - Wollert, Jörg ED - Leipzig, Hochschule für Technik, Wirtschaft und Kultur T1 - Rapid prototyping framework for automation applications based on IO-Link T2 - Tagungsband AALE 2022: Wissenstransfer im Spannungsfeld von Autonomisierung und Fachkräftemangel N2 - The development of protype applications with sensors and actuators in the automation industry requires tools that are independent of manufacturer, and are flexible enough to be modified or extended for any specific requirements. Currently, developing prototypes with industrial sensors and actuators is not straightforward. First of all, the exchange of information depends on the industrial protocol that these devices have. Second, a specific configuration and installation is done based on the hardware that is used, such as automation controllers or industrial gateways. This means that the development for a specific industrial protocol, highly depends on the hardware and the software that vendors provide. In this work we propose a rapid-prototyping framework based on Arduino to solve this problem. For this project we have focused to work with the IO-Link protocol. The framework consists of an Arduino shield that acts as the physical layer, and a software that implements the IO-Link Master protocol. The main advantage of such framework is that an application with industrial devices can be rapid-prototyped with ease as its vendor independent, open-source and can be ported easily to other Arduino compatible boards. In comparison, a typical approach requires proprietary hardware, is not easy to port to another system and is closed-source. KW - Rapid-prototyping KW - Arduino KW - IO-Link KW - Industrial Communication Y1 - 2022 SN - 978-3-910103-00-9 U6 - https://doi.org/10.33968/2022.28 N1 - 18. AALE-Konferenz. Pforzheim, 09.03.-11.03.2022 CY - Leipzig ER - TY - CHAP A1 - Ulmer, Jessica A1 - Mostafa, Youssef A1 - Wollert, Jörg T1 - Digital Twin Academy: From Zero to Hero through individual learning experiences T2 - Tagungsband AALE 2022: Wissenstransfer im Spannungsfeld von Autonomisierung und Fachkräftemangel N2 - Digital twins are seen as one of the key technologies of Industry 4.0. Although many research groups focus on digital twins and create meaningful outputs, the technology has not yet reached a broad application in the industry. The main reasons for this imbalance are the complexity of the topic, the lack of specialists, and the unawareness of the twin opportunities. The project "Digital Twin Academy" aims to overcome these barriers by focusing on three actions: Building a digital twin community for discussion and exchange, offering multi-stage training for various knowledge levels, and implementing realworld use cases for deeper insights and guidance. In this work, we focus on creating a flexible learning platform that allows the user to select a training path adjusted to personal knowledge and needs. Therefore, a mix of basic and advanced modules is created and expanded by individual feedback options. The usage of personas supports the selection of the appropriate modules. KW - Digital Twins KW - Knowledge Transfer KW - Training Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bsz:l189-qucosa2-776097 SN - 978-3-910103-00-9 N1 - 18. AALE-Konferenz. Pforzheim, 09.03.-11.03.2022 SP - 1 EP - 9 ER - TY - JOUR A1 - Kempt, Hendrik A1 - Freyer, Nils A1 - Nagel, Saskia K. T1 - Justice and the normative standards of explainability in healthcare JF - Philosophy & Technology N2 - Providing healthcare services frequently involves cognitively demanding tasks, including diagnoses and analyses as well as complex decisions about treatments and therapy. From a global perspective, ethically significant inequalities exist between regions where the expert knowledge required for these tasks is scarce or abundant. One possible strategy to diminish such inequalities and increase healthcare opportunities in expert-scarce settings is to provide healthcare solutions involving digital technologies that do not necessarily require the presence of a human expert, e.g., in the form of artificial intelligent decision-support systems (AI-DSS). Such algorithmic decision-making, however, is mostly developed in resource- and expert-abundant settings to support healthcare experts in their work. As a practical consequence, the normative standards and requirements for such algorithmic decision-making in healthcare require the technology to be at least as explainable as the decisions made by the experts themselves. The goal of providing healthcare in settings where resources and expertise are scarce might come with a normative pull to lower the normative standards of using digital technologies in order to provide at least some healthcare in the first place. We scrutinize this tendency to lower standards in particular settings from a normative perspective, distinguish between different types of absolute and relative, local and global standards of explainability, and conclude by defending an ambitious and practicable standard of local relative explainability. KW - Clinical decision support systems KW - Justice KW - Medical AI KW - Explainability KW - Normative standards Y1 - 2022 U6 - https://doi.org/10.1007/s13347-022-00598-0 VL - 35 IS - Article number: 100 SP - 1 EP - 19 PB - Springer Nature CY - Berlin ER - TY - JOUR A1 - Thiebes, Anja Lena A1 - Klein, Sarah A1 - Zingsheim, Jonas A1 - Möller, Georg H. A1 - Gürzing, Stefanie A1 - Reddemann, Manuel A. A1 - Behbahani, Mehdi A1 - Cornelissen, Christian G. T1 - Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio JF - pharmaceutics N2 - Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4–33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing. KW - tri-lineage differentiation KW - survival KW - twin-fluid atomizer KW - adipose-derived stromal cells (ASCs) KW - cell atomization KW - cell aerosolization Y1 - 2022 U6 - https://doi.org/10.3390/pharmaceutics14112421 N1 - This article belongs to the Special Issue "Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells" VL - 14 IS - 11 PB - MDPI CY - Basel ER - TY - JOUR A1 - Stäudle, Benjamin A1 - Seynnes, Olivier A1 - Laps, Guido A1 - Brüggemann, Gert-Peter A1 - Albracht, Kirsten T1 - Altered gastrocnemius contractile behavior in former achilles tendon rupture patients during walking JF - Frontiers in Physiology N2 - Achilles tendon rupture (ATR) remains associated with functional limitations years after injury. Architectural remodeling of the gastrocnemius medialis (GM) muscle is typically observed in the affected leg and may compensate force deficits caused by a longer tendon. Yet patients seem to retain functional limitations during—low-force—walking gait. To explore the potential limits imposed by the remodeled GM muscle-tendon unit (MTU) on walking gait, we examined the contractile behavior of muscle fascicles during the stance phase. In a cross-sectional design, we studied nine former patients (males; age: 45 ± 9 years; height: 180 ± 7 cm; weight: 83 ± 6 kg) with a history of complete unilateral ATR, approximately 4 years post-surgery. Using ultrasonography, GM tendon morphology, muscle architecture at rest, and fascicular behavior were assessed during walking at 1.5 m⋅s–1 on a treadmill. Walking patterns were recorded with a motion capture system. The unaffected leg served as control. Lower limbs kinematics were largely similar between legs during walking. Typical features of ATR-related MTU remodeling were observed during the stance sub-phases corresponding to series elastic element (SEE) lengthening (energy storage) and SEE shortening (energy release), with shorter GM fascicles (36 and 36%, respectively) and greater pennation angles (8° and 12°, respectively). However, relative to the optimal fascicle length for force production, fascicles operated at comparable length in both legs. Similarly, when expressed relative to optimal fascicle length, fascicle contraction velocity was not different between sides, except at the time-point of peak series elastic element (SEE) length, where it was 39 ± 49% lower in the affected leg. Concomitantly, fascicles rotation during contraction was greater in the affected leg during the whole stance-phase, and architectural gear ratios (AGR) was larger during SEE lengthening. Under the present testing conditions, former ATR patients had recovered a relatively symmetrical walking gait pattern. Differences in seen AGR seem to accommodate the profound changes in MTU architecture, limiting the required fascicle shortening velocity. Overall, the contractile behavior of the GM fascicles does not restrict length- or velocity-dependent force potentials during this locomotor task. KW - tendon rupture KW - muscle fascicle behavior KW - walking gait KW - force generation KW - ultrasound imaging Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.792576 SN - 1664-042X VL - 13 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Strüder, Heiko K. T1 - Biomechanics of all-out handcycling exercise: kinetics, kinematics and muscular activity of a 15-s sprint test in able-bodied participants JF - Sports Biomechanics N2 - This study aims to quantify the kinematics, kinetics and muscular activity of all-out handcycling exercise and examine their alterations during the course of a 15-s sprint test. Twelve able-bodied competitive triathletes performed a 15-s all-out sprint test in a recumbent racing handcycle that was attached to an ergometer. During the sprint test, tangential crank kinetics, 3D joint kinematics and muscular activity of 10 muscles of the upper extremity and trunk were examined using a power metre, motion capturing and surface electromyography (sEMG), respectively. Parameters were compared between revolution one (R1), revolution two (R2), the average of revolution 3 to 13 (R3) and the average of the remaining revolutions (R4). Shoulder abduction and internal-rotation increased, whereas maximal shoulder retroversion decreased during the sprint. Except for the wrist angles, angular velocity increased for every joint of the upper extremity. Several muscles demonstrated an increase in muscular activation, an earlier onset of muscular activation in crank cycle and an increased range of activation. During the course of a 15-s all-out sprint test in handcycling, the shoulder muscles and the muscles associated to the push phase demonstrate indications for short-duration fatigue. These findings are helpful to prevent injuries and improve performance in all-out handcycling. KW - Handbike KW - sEMG KW - Paralympic sport KW - performance testing KW - high-intensity exercise Y1 - 2022 U6 - https://doi.org/10.1080/14763141.2020.1745266 SN - 1752-6116 (Onlineausgabe) SN - 1476-3141 (Druckausgabe) VL - 21 IS - 10 SP - 1200 EP - 1223 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Finkenberger, Isabel Maria T1 - Strukturwandel als transformative Wende JF - disP: The Planning Review Y1 - 2024 U6 - https://doi.org/10.1080/02513625.2022.2158603 SN - 0251-3625 VL - 58 IS - 3 SP - 86 EP - 94 PB - Taylor & Francis CY - Abingdon ER - TY - CHAP A1 - Finkenberger, Isabel Maria ED - Pufke, Andrea T1 - Räumliche Transformation als Planungsaufgabe T2 - Zurück in die Zukunft. Denkmalpflege und Strukturwandel im Rheinischen Revier Y1 - 2024 N1 - Mitteilungen aus dem LVR-Amt für Denkmalpflege im Rheinland 39 : Zurück in die Zukunft. Denkmalpflege und Strukturwandel im Rheinischen Revier. Dokumentation zum 7. Rheinischen Tag für Denkmalpflege in Morschenich, 2. Juni 2022 SP - 70 EP - 77 PB - LVR-Amt für Denkmalpflege im Rheinland CY - Pulheim ER - TY - JOUR A1 - Angermann, Susanne A1 - Günthner, Roman A1 - Hanssen, Henner A1 - Lorenz, Georg A1 - Braunisch, Matthias C. A1 - Steubl, Dominik A1 - Matschkal, Julia A1 - Kemmner, Stephan A1 - Hausinger, Renate A1 - Block, Zenonas A1 - Haller, Bernhard A1 - Heemann, Uwe A1 - Kotliar, Konstantin A1 - Grimmer, Timo A1 - Schmaderer, Christoph T1 - Cognitive impairment and microvascular function in end-stage renal disease JF - International Journal of Methods in Psychiatric Research (MPR) N2 - Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention. KW - cerebral small vessel disease KW - cognitive impairment KW - dialysis KW - retinal vessels Y1 - 2022 U6 - https://doi.org/10.1002/mpr.1909 SN - 1049-8931 (Print) SN - 1557-0657 (Online) VL - 31 IS - 2 SP - 1 EP - 10 PB - Wiley ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Ortner, Marion A1 - Conradi, Anna A1 - Hacker, Patricia A1 - Hauser, Christine A1 - Günthner, Roman A1 - Moser, Michaela A1 - Muggenthaler, Claudia A1 - Diehl-Schmid, Janine A1 - Priller, Josef A1 - Schmaderer, Christoph A1 - Grimmer, Timo T1 - Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance JF - Neurobiology of Aging N2 - Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis. KW - Alzheimer's disease KW - Retinal vessel analysis KW - Vasomotions KW - Pulsations KW - Mild cognitive impairment Y1 - 2022 U6 - https://doi.org/10.1016/j.neurobiolaging.2022.08.012 SN - 0197-4580 VL - 120 SP - 117 EP - 127 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Moorkamp, Wilfried A1 - Peterson, Leif Arne A1 - Uibel, Thomas ED - Fouad, Nabil A. T1 - Nachhaltige Holzbrücken für Geh- und Radwege T2 - Bauphysik Kalender 2022: Holzbau, 22. Jahrgang N2 - Am Lehr- und Forschungsgebiet Holzbau der Fachhochschule Aachen wurden im Rahmen des Forschungsvorhabens „Nachhaltige Standardbrücken in Holzbauweise“ Standardtypen für Geh- und Radwegbrücken entwickelt. Die Brücken sind durch konsequente Umsetzungen von Maßnahmen des konstruktiven Holzschutzes für eine Nutzung von mehr als 80~Jahren konzipiert. Innovative Lösungen für Bauteile und Anschlüsse sowie Materialalternativen im Bereich des Belages und der Geländer ermöglichen eine wartungsarme Konstruktion und tragen somit zur Wirtschaftlichkeit und Nachhaltigkeit bei. Um den Einsatz der entwickelten Standardbrückentypen in der Praxis zu erleichtern, wurden Leistungsverzeichnisse, Musterstatiken, Musterzeichnungen und umfangreiche Detailkataloge als Unterstützung für Planer und Bauherren erstellt. Damit die Randbedingungen für eine lange Lebensdauer während der Nutzung der Brücke erhalten bleiben, wurden Leitfäden für die Pflege und Wartung sowie für die Brückenprüfung erarbeitet. Der Beitrag gibt Einblicke in das Forschungsvorhaben und seine Resultate. Y1 - 2022 SN - 9783433033609 (Print) SN - 9783433611081 (Online) U6 - https://doi.org/10.1002/9783433611081.ch17 SP - 574 EP - 592 PB - Ernst & Sohn CY - Berlin ER - TY - JOUR A1 - Werfel, Stanislas A1 - Günthner, Roman A1 - Hapfelmeier, Alexander A1 - Hanssen, Henner A1 - Kotliar, Konstantin A1 - Heemann, Uwe A1 - Schmaderer, Christoph ED - Guzik, Tomasz J. T1 - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning JF - Cardiovascular Research N2 - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations. KW - Machine learning KW - Retinal vessels KW - Microcirculation KW - Haemodialysis KW - Myocardial infarction and cardiac death Y1 - 2022 U6 - https://doi.org/10.1093/cvr/cvab040 SN - 0008-6363 VL - 118 IS - 2 SP - 612 EP - 621 PB - Oxford University Press CY - Oxford ER - TY - CHAP A1 - Veettil, Yadu Krishna Morassery A1 - Rakshit, Shantam A1 - Schopen, Oliver A1 - Kemper, Hans A1 - Esch, Thomas A1 - Shabani, Bahman ED - Bin Abdollah, Mohd Fadzli ED - Amiruddin, Hilmi ED - Singh, Amrik Singh Phuman ED - Munir, Fudhail Abdul ED - Ibrahim, Asriana T1 - Automated Control System Strategies to Ensure Safety of PEM Fuel Cells Using Kalman Filters T2 - Proceedings of the 7th International Conference and Exhibition on Sustainable Energy and Advanced Materials (ICE-SEAM 2021), Melaka, Malaysia N2 - Having well-defined control strategies for fuel cells, that can efficiently detect errors and take corrective action is critically important for safety in all applications, and especially so in aviation. The algorithms not only ensure operator safety by monitoring the fuel cell and connected components, but also contribute to extending the health of the fuel cell, its durability and safe operation over its lifetime. While sensors are used to provide peripheral data surrounding the fuel cell, the internal states of the fuel cell cannot be directly measured. To overcome this restriction, Kalman Filter has been implemented as an internal state observer. Other safety conditions are evaluated using real-time data from every connected sensor and corrective actions automatically take place to ensure safety. The algorithms discussed in this paper have been validated thorough Model-in-the-Loop (MiL) tests as well as practical validation at a dedicated test bench. KW - control system KW - PEM fuel cells KW - Kalman filter Y1 - 2022 SN - 978-981-19-3178-9 SN - 978-981-19-3179-6 (E-Book) U6 - https://doi.org/10.1007/978-981-19-3179-6_55 SN - 2195-4356 N1 - 7th International Conference and Exhibition on Sustainable Energy and Advanced Material (ICE-SEAM 2021), Universiti Teknikal Malaysia Melaka (UTeM), Malaysia, in association with the Universitas Sebelas Maret (UNS), Indonesia, 23 November 2021 SP - 296 EP - 299 PB - Springer Nature CY - Singapore ER - TY - CHAP A1 - Schopen, Oliver A1 - Shabani, Bahman A1 - Esch, Thomas A1 - Kemper, Hans A1 - Shah, Neel ED - Rahim, S.A. ED - As'arry, A. ED - Zuhri, M.Y.M. ED - Harmin, M.Y. ED - Rezali, K.A.M. ED - Hairuddin, A.A. T1 - Quantitative evaluation of health management designs for fuel cell systems in transport vehicles T2 - 2nd UNITED-SAIG International Conference Proceedings N2 - Focusing on transport vehicles, mainly with regard to aviation applications, this paper presents compilation and subsequent quantitative evaluation of methods aimed at building an optimum integrated health management solution for fuel cell systems. The methods are divided into two different main types and compiled in a related scheme. Furthermore, different methods are analysed and evaluated based on parameters specific to the aviation context of this study. Finally, the most suitable method for use in fuel cell health management systems is identified and its performance and suitability is quantified. KW - aviation application KW - health management systems KW - fuel cell systems Y1 - 2022 N1 - 2nd UNITED-SAIG International Conference, 23-24 May 2022, Putrajaya, Malaysia SP - 1 EP - 3 ER - TY - JOUR A1 - Falkenberg, Fabian A1 - Bott, Michael A1 - Bongaerts, Johannes A1 - Siegert, Petra T1 - Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae JF - Frontiers in Microbiology N2 - The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions. Subtilases are divided in several groups and especially subtilisins are of interest as they are used in various industrial sectors. Therefore, we searched for new subtilisin sequences of the family Bacillaceae using a data mining approach. The obtained 1,400 sequences were phylogenetically classified in the context of the subtilase family. This required an updated comprehensive overview of the different groups within this family. To fill this gap, we conducted a phylogenetic survey of the S8 family with characterised holotypes derived from the MEROPS database. The analysis revealed the presence of eight previously uncharacterised groups and 13 subgroups within the S8 family. The sequences that emerged from the data mining with the set filter parameters were mainly assigned to the subtilisin subgroups of true subtilisins, high-alkaline subtilisins, and phylogenetically intermediate subtilisins and represent an excellent source for new subtilisin candidates. Y1 - 2022 U6 - https://doi.org/10.3389/fmicb.2022.1017978 SN - 1664-302X VL - 2022 IS - 13 PB - Frontiers CY - Lausanne ER - TY - CHAP A1 - Losse, Ann-Kathrin A1 - Gehrke, Melanie A1 - Ullrich, André A1 - Czarnecki, Christian A1 - Sultanow, Eldar A1 - Breithaupt, Carsten A1 - Koch, Christian T1 - Entwicklung einer Open-Data-Referenzarchitektur für die Luftfahrtindustrie T2 - INFORMATIK 2022 - Informatik in den Naturwissenschaften, Proceedings N2 - Open Data impliziert die freie Zugänglichkeit, Verfügbarkeit und Wiederverwendbarkeit von Datensätzen. Obwohl hochwertige Datensätze öffentlich verfügbar sind, ist der Zugang zu diesen und die Transparenz über die Formate nicht immer gegeben. Dies mindert die optimale Nutzung des Potenzials zur Wertschöpfung, trotz der vorherrschenden Einigkeit über ihre Chancen. Denn Open Data ermöglicht das Vorantreiben von Compliance-Themen wie Transparenz und Rechenschaftspflicht bis hin zur Förderung von Innovationen. Die Nutzung von Open Data erfordert Mut und eine gemeinsame Anstrengung verschiedener Akteure und Branchen. Im Rahmen des vorliegenden Beitrags werden auf Grundlage des Design Science-Ansatzes eine Open Data Capability Map sowie darauf aufbauend eine Datenarchitektur für Open Data in der Luftfahrtindustrie an einem Beispiel entwickelt. Y1 - 2022 SN - 978-3-88579-720-3 U6 - https://doi.org/10.18420/inf2022_103 SN - 1617-5468 N1 - INFORMATIK 2022, 26. - 30. September 2022, Hamburg SP - 1203 EP - 1209 PB - GI - Gesellschaft für Informatik CY - Bonn ER -