TY  - JOUR
A1  - Ermolaev, A.P.
A1  - Nivokov, I.A.
A1  - Melnikova, L.I.
A1  - Kotliar, Konstantin
T1  - Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой
T1  - Comparative characteristics of the chemical composition of vitreal contents of cadaver eyes and eyes with terminal refractory glaucoma
JF  - Vestnik oftalmologii
N2  - Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.
Y1  - 2018
U6  - http://dx.doi.org/10.17116/oftalma2018134051195
VL  - 5
IS  - 2
SP  - 195
EP  - 201
PB  - Media Sfera
CY  - Moskau
ER  - 
TY  - JOUR
A1  - Ketelhut, Maike
A1  - Göll, Fabian
A1  - Braunstein, Björn
A1  - Albracht, Kirsten
A1  - Abel, Dirk
T1  - Comparison of different training algorithms for the leg extension training with an industrial robot
JF  - Current Directions in Biomedical Engineering
N2  - In the past, different training scenarios have been developed and implemented on robotic research platforms, but no systematic analysis and comparison have been done so far. This paper deals with the comparison of an isokinematic (motion with constant velocity) and an isotonic (motion against constant weight) training algorithm. Both algorithms are designed for a robotic research platform consisting of a 3D force plate and a high payload industrial robot, which allows leg extension training with arbitrary six-dimensional motion trajectories. In the isokinematic as well as the isotonic training algorithm, individual paths are defined i n C artesian s pace by sufficient s upport p oses. I n t he i sotonic t raining s cenario, the trajectory is adapted to the measured force as the robot should only move along the trajectory as long as the force applied by the user exceeds a minimum threshold. In the isotonic training scenario however, the robot’s acceleration is a function of the force applied by the user. To validate these findings, a simulative experiment with a simple linear trajectory is performed. For this purpose, the same force path is applied in both training scenarios. The results illustrate that the algorithms differ in the force dependent trajectory adaption.
KW  - Rehabilitation Technology and Prosthetics
KW  - Surgical Navigation and Robotics
Y1  - 2018
U6  - http://dx.doi.org/10.1515/cdbme-2018-0005
SN  - 2364-5504
VL  - 4
IS  - 1
SP  - 17
EP  - 20
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J
A1  - Paulsen, Gøran
A1  - Bojsen-Møller, Jens
A1  - Seynnes, Olivier R
T1  - Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing
JF  - Frontiers in physiology
N2  - During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation.
KW  - achilles tendon
KW  - energy absorption
KW  - energy dissipation
KW  - mechanical buffer
KW  - stiffness
Y1  - 2018
U6  - http://dx.doi.org/10.3389/fphys.2018.00794
SN  - 1664-042X
IS  - 9
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Kotliar, Konstantin
A1  - Lüke, Jan Niklas
A1  - Alpdogan, Serdar
A1  - Conzen, Catharina
A1  - Lindauer, Ute
A1  - Clusmann, Hans
A1  - Hescheler, Jürgen
A1  - Vilser, Walthard
A1  - Schneider, Toni
A1  - Schubert, Gerrit Alexander
T1  - Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis
JF  - Plos one
N2  - Background
Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC.

Methods
A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed.

Results
A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001).

Conclusions
To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.
Y1  - 2018
U6  - http://dx.doi.org/10.1371/journal.pone.0204689
VL  - 13
IS  - 10
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Hackl, M.
A1  - Andermahr, J.
A1  - Staat, Manfred
A1  - Bremer, I.
A1  - Borggrefe, J.
A1  - Prescher, A.
A1  - Müller, L. P.
A1  - Wegmann, K.
T1  - Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation
JF  - The Journal of Hand Surgery (European Volume)
Y1  - 2017
U6  - http://dx.doi.org/10.1177/1753193416665943
SN  - 2043-6289 (Online)
SN  - 1753-1934 (Print)
VL  - 42
IS  - 4
SP  - 370
EP  - 376
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Lanzl, I.
A1  - Kotliar, Konstantin
T1  - Können Anti-VEGF-Injektionen Glaukom oder okuläre Hypertension verursachen?
T1  - Can Anti-VEGF Injections Cause Glaucoma or Ocular Hypertension?
JF  - Klinische Monatsblätter für Augenheilkunde
Y1  - 2017
U6  - http://dx.doi.org/10.1055/s-0043-101819
SN  - 0023-2165
VL  - 234
IS  - 2
SP  - 191
EP  - 193
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Kahmann, Stephanie Lucina
A1  - Heinze, Nicolai
A1  - Staat, Manfred
A1  - Neiss, Wolfram F.
A1  - Scaal, Martin
A1  - Müller, Lars P.
T1  - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow
JF  - Knee Surgery, Sports Traumatology, Arthroscopy
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s00167-017-4468-z
SN  - 1433-7347
VL  - 25
IS  - 7
SP  - 2280
EP  - 2288
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Zange, Jochen
A1  - Schopen, Kathrin
A1  - Albracht, Kirsten
A1  - Gerlach, Darius A.
A1  - Frings-Meuthen, Petra
A1  - Maffiuletti, Nicola A.
A1  - Bloch, Wilhelm
A1  - Rittweger, Jörn
T1  - Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial
JF  - Plos one
Y1  - 2017
U6  - http://dx.doi.org/10.1371/journal.pone.0171562
VL  - 12
IS  - 2
ER  - 
TY  - JOUR
A1  - Michael, Hackl
A1  - Mayer, Katharina
A1  - Weber, Mareike
A1  - Staat, Manfred
A1  - van Riet, Roger
A1  - Burkhart, Klau Josef
A1  - Müller, Lars Peter
A1  - Wegmann, Kilian
T1  - Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis
JF  - The journal of hand surgery
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.jhsa.2017.05.014
SN  - 0363-5023
VL  - 42
IS  - 10
SP  - 834.e1
EP  - 834.e7
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
T1  - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement
JF  - Journal of the mechanical behavior of biomedical materials
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.jmbbm.2017.06.012
SN  - 1751-6161
VL  - 74
SP  - 400
EP  - 410
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Tran, Linda
A1  - Mottaghy, K.
A1  - Arlt-Körfer, Sabine
A1  - Waluga, Christian
A1  - Behbahani, Mehdi
T1  - An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system
JF  - Biomedizinische Technik
Y1  - 2017
U6  - http://dx.doi.org/10.1515/bmt-2015-0034
SN  - 0013-5585
VL  - 62
IS  - 4
SP  - 383
EP  - 392
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lueke, Jan Niklas
A1  - Sjapic, Volha
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Sjapic, Sergej
A1  - Alpdogan, Serdan
A1  - Schneider, Toni
A1  - Schubert, Gerrit Alexander
A1  - Neumaier, Felix
T1  - Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina
JF  - Current Eye Research
Y1  - 2017
U6  - http://dx.doi.org/10.1080/02713683.2017.1339807
SN  - 1460-2202
IS  - Article in press
SP  - 1
EP  - 9
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Seifarth, Volker
A1  - Grosse, Joachim O.
A1  - Grossmann, Matthias
A1  - Janke, Heinz Peter
A1  - Arndt, Patrick
A1  - Koch, Sabine
A1  - Epple, Matthias
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation
JF  - Journal of Biomaterials Applications
Y1  - 2017
U6  - http://dx.doi.org/10.1177/0885328217723178
SN  - 1530-8022
VL  - 32
IS  - 3
SP  - 321
EP  - 330
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Kotliar, Konstantin
A1  - Hauser, Christine
A1  - Ortner, Marion
A1  - Muggenthaler, Claudia
A1  - Diehl-Schmid, Janine
A1  - Angermann, Susanne
A1  - Hapfelmeier, Alexander
A1  - Schmaderer, Christoph
A1  - Grimmer, Timo
T1  - Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
JF  - Scientific Reports
Y1  - 2017
U6  - http://dx.doi.org/10.1038/s41598-017-13349-5
SN  - 2045-2322
N1  - Article 12906
VL  - 7
IS  - 1
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J.
A1  - Meier, Rahel
A1  - Mojsen-Moeller, Jens
A1  - Seynnes, Olivier R.
T1  - Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task
JF  - Journal of Experimental Biology
Y1  - 2017
U6  - http://dx.doi.org/10.1242/jeb.164111
SN  - 0022-0949
VL  - 220
IS  - 22
SP  - 4141
EP  - 4149
ER  - 
TY  - JOUR
A1  - Peloni, Alessandro
A1  - Dachwald, Bernd
A1  - Ceriotti, Matteo
T1  - Multiple near-earth asteroid rendezvous mission: Solar-sailing options
JF  - Advances in Space Research
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.asr.2017.10.017
SN  - 0273-1177
IS  - In Press, Corrected Proof
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Savitskaya, I. S.
A1  - Kistaubayeva, A. S.
A1  - Digel, Ilya
A1  - Shokatayeva, D. H.
T1  - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials
JF  - Eurasian Chemico-Technological Journal
Y1  - 2017
U6  - http://dx.doi.org/10.18321/ectj670
SN  - 2522-4867
VL  - 19
IS  - 3
SP  - 255
EP  - 264
ER  - 
TY  - JOUR
A1  - Müller, Wolfram
A1  - Jung, Alexander
A1  - Ahammer, Helmut
T1  - Advantages and problems of nonlinear methods applied to analyze physiological time signals: human balance control as an example
JF  - Scientific Reports
Y1  - 2017
SN  - 2045-2322
U6  - http://dx.doi.org/10.1038/s41598-017-02665-5
VL  - 7
IS  - Article number 2464
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Kowalski, Julia
A1  - Linder, Peter
A1  - Zierke, S.
A1  - Wulfen, B. van
A1  - Clemens, J.
A1  - Konstantinidis, K.
A1  - Ameres, G.
A1  - Hoffmann, R.
A1  - Mikucki, J.
A1  - Tulaczyk, S.
A1  - Funke, O.
A1  - Blandfort, D.
A1  - Espe, Clemens
A1  - Feldmann, Marco
A1  - Francke, Gero
A1  - Hiecker, S.
A1  - Plescher, Engelbert
A1  - Schöngarth, Sarah
A1  - Dachwald, Bernd
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Eliseev, D.
A1  - Heinen, D.
A1  - Scholz, F.
A1  - Wiebusch, C.
A1  - Macht, S.
A1  - Bestmann, U.
A1  - Reineking, T.
A1  - Zetzsche, C.
A1  - Schill, K.
A1  - Förstner, R.
A1  - Niedermeier, H.
A1  - Szumski, A.
A1  - Eissfeller, B.
A1  - Naumann, U.
A1  - Helbing, K.
T1  - Navigation technology for exploration of glacier ice with maneuverable melting probes
JF  - Cold Regions Science and Technology
N2  - The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.coldregions.2015.11.006
SN  - 0165-232X
IS  - 123
SP  - 53
EP  - 70
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Goßmann, Matthias
A1  - Frotscher, Ralf
A1  - Linder, Peter
A1  - Bayer, Robin
A1  - Epple, U.
A1  - Staat, Manfred
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells
JF  - Cellular physiology and biochemistry
N2  - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
KW  - Inotropic compounds
KW  - Pharmacology
KW  - Ion channels
KW  - CellDrum
KW  - Heart tissue culture
KW  - Induced pluripotent stem cells
KW  - Cardiac myocytes
Y1  - 2016
U6  - http://dx.doi.org/10.1159/000443124
SN  - 1421-9778 (Online)
SN  - 1015-8987 (Print)
VL  - 38
IS  - 3
SP  - 1182
EP  - 1198
PB  - Karger
CY  - Basel
ER  -