TY - JOUR A1 - Poghossian, Arshak A1 - Berndsen, L. A1 - Lüth, H. A1 - Schultze, J. W. A1 - Schöning, Michael Josef T1 - Multi-Parameter-Detektions-System unter dem Einsatz eines einzigen Transducerprinzips sowohl für (bio-)chemische als auch physikalische Sensoren JF - Sensoren und Mess-Systeme : Vorträge der 11. ITG/GMA-Fachtagung vom 11. bis 12. März 2002 in Ludwigsburg / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ... Wiss. Tagungsleitung: C. D. Kohl .... Y1 - 2002 SN - 3-8007-2675-0 N1 - Sensoren und Mess-Systeme 2002 SP - 137 EP - 140 PB - VDE-Verl. CY - Berlin [u.a.] ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefan T1 - Mathematical and Numerical Analysis of a Robust and Efficient Grid Deformation Method in the Finite Element Context JF - SIAM Journal on Scientific Computing Y1 - 2009 U6 - https://doi.org/10.1137/050639387 VL - 31 IS - 2 SP - 1539 EP - 1557 PB - Society for Industrial and Applied Mathematics CY - Philadelphia, Pa. ER - TY - JOUR A1 - Staat, Manfred A1 - Ballmann, J. T1 - Zur Problematik tensorieller Verallgemeinerungen einachsiger nichtlinearer Materialgesetze JF - Zeitschrift für angewandte Mathematik und Mechanik : ZAMM. 69 (1989), H. 2 Y1 - 1989 SN - 0946-8463 U6 - https://doi.org/10.1515/9783112553169-006 SP - 73 EP - 81 ER - TY - JOUR A1 - Aimenova, Zh. E. A1 - Digel, Ilya A1 - Eshibaev, А. А. T1 - Dynamics of accumulation of lagochirzin in Lagochilus setulosus phytomass during the growing season and also features of its cultivation in the conditions of a typical sierozem JF - KazNU Bulletin. Biology series N2 - L.setulosus is offered for creation of biopreparation «Setulin», possesing he- mostatic action, the basic reactant of biopreparation is diterpen – lagochirzin. Results under the maintenance and dynamics of diterpen lagochirzin accumula- tion in various parts of L.setulosus are presented: in roots, stalks, leaves, flowers and calyx lobes during the growing season, and also results on conditions of cultivation L.setulosus in the conditions of a typical sierozem are resulted. From the obtained data is visible, that the given species of a plant is endemic. It is established, that dynamics of accumulation of lagochirzin in phytomass accrues from the beginning to the middle of the growing season. The chemical analysis of L.setulosus on a localization of lagochirzin in various organs of a plant, has shown, that the greatest quantity of lagochirzin collects in calyx lobes of the plants. Also it is established, that L.setulosus can be cultivated in the conditions of the typical sierozem, a mineral food is necessary for the given species of plants of Lagochilus genus, except nitric fertilizers. Comparative studying of wild-growing and cultural forms of L.setulosus has shown, that in the cultivated phytomass of plants the maintenance of lagochirzin on 17-20 % higher than in the wild-growing species. Y1 - 2016 SN - 1563-0218 N1 - Original in russischer Sprache VL - 69 IS - 4 SP - 4 EP - 11 PB - Al-Farabi Kazakh National University CY - Almaty ER - TY - JOUR A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Schnitzler, Thomas A1 - Biselli, Manfred A1 - Zang, Werner A1 - Wagner, P. T1 - Entwicklung eines modularen festkörperbasierten Sensorsystems für die Überwachung von Zellkulturfermentationen JF - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA) Y1 - 2010 SN - 978-3-8007-3260-9 N1 - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik SP - 688 EP - 698 PB - VDE Verlag CY - Berlin ER - TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Savitkaya, I.S. A1 - Zhubanova, A.A. A1 - Tastambek, K.T. T1 - Investigations of LPS endotoxin elimination in the flowing column conditions with the sorbent on the basis of carbonized rice husk JF - KazNU Bulletin. Biology series Y1 - 2013 SN - 1563-0218 N1 - Original in russischer Sprache VL - 57 IS - 1 SP - 124 EP - 127 ER - TY - JOUR A1 - Laack, Walter van A1 - Refisch, A. T1 - Die neuralgische Amyotrophie des Lumbalbereiches / Refisch, A. ; Laack, W. van JF - Orthopädische Praxis. 7 (1989) Y1 - 1989 SN - 0030-588x SP - 437 ER - TY - JOUR A1 - Laack, Walter van A1 - Ohnsorge, J. T1 - Technik und Ergebnisse der arthroskopischen Fixation von Dissekaten an der medialen Femurrolle mit resorbierbaren EthipinR-Stiften JF - Abstracts : SICOT 87, XVII. world congress, Munich, 16 - 21 August 1987 / [ed.: H. Wagner] Y1 - 1987 SN - 3-921512-85-9 N1 - International Society of Orthopaedic Surgery and Traumatology / Société Internationale de Chirurgie Orthopédique et de Traumatologie SP - 277 PB - Demeter CY - Gräfelfing ER - TY - JOUR A1 - Bialonski, Stephan A1 - Wellmer, Jörg A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis JF - Epilepsia Y1 - 2006 SN - 0013-9580 VL - 47 SP - 36 ER - TY - JOUR A1 - Laack, Walter van A1 - Refisch, A. A1 - Ohnsorge, J. A1 - Dürselen, L. T1 - Proximaler Femurteilersatz - Alternative zum Schaftwechsel zementfixierter Hüftendoprothesen JF - Orthopädische Praxis. 20 (1984), H. 11 Y1 - 1984 SN - 0030-588x SP - 856 ER - TY - JOUR A1 - Staat, Manfred T1 - Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability JF - Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in Jülich, 21-24 November 1994 Y1 - 1996 N1 - IAEA-TECDOC-920 ; Onlinezugriff erfolgt auf die überarb. Ausg. 2006 SP - 43 EP - 55 CY - Vienna ER - TY - JOUR A1 - Stulpe, Werner T1 - Conditional Expectations, Conditional Distributions, and A Posteriori Ensembles in Generalized Probability Theory JF - International Journal of Theoretical Physics. 27 (1988), H. 5 Y1 - 1988 SN - 1572-9575 SP - 587 EP - 611 ER - TY - JOUR A1 - Laack, Walter van T1 - Allgemeine physiotherapeutische Behandlung nach Hüft- und Kniegelenkoperationen JF - Physiotherapie. 77 (1986), H. 2 Y1 - 1986 SN - 0031-9392 SP - 68 EP - 72 ER - TY - JOUR A1 - Karschuck, Tobias A1 - Poghossian, Arshak A1 - Ser, Joey A1 - Tsokolakyan, Astghik A1 - Achtsnicht, Stefan A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage JF - Sensors and Actuators B: Chemical N2 - Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed. KW - Field-effect biosensor KW - Capacitive model KW - Enzyme coverage KW - Multianalyte detection KW - Penicillin Y1 - 2024 U6 - https://doi.org/10.1016/j.snb.2024.135530 SN - 0925-4005 (Print) SN - 1873-3077 (Online) N1 - Corresponding Author: Michael J. Schöning VL - 408 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Özsoylu, Dua A1 - Kizildag, Sefa A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS) JF - Physics in Medicine N2 - Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO–K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO–K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images. Y1 - 2020 U6 - https://doi.org/10.1016/j.phmed.2020.100030 SN - 2352-4510 VL - 10 IS - 100030 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Pourshahidi, Mohammad Ali A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation JF - Journal of Magnetism and Magnetic Materials N2 - Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing. Y1 - 2022 U6 - https://doi.org/10.1016/j.jmmm.2022.169965 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Tödter, Julia A1 - Niehues, Julia A1 - Telöken, Matthias A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim A1 - Schröper, Florian T1 - 3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection JF - Sensors N2 - For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated. Y1 - 2019 U6 - https://doi.org/10.3390/s19010148 SN - 1424-8220 VL - 19 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shalaby, Ahmed A1 - Shasha, Carolyn A1 - Krishnan, Kannan M. A1 - Krause, Hans-Joachim T1 - Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory JF - Nanomaterials N2 - Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90% of the frequency mixing magnetic response signal is generated by the largest 10% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory. KW - Magnetic nanoparticles KW - Frequency mixing magnetic detection KW - Langevin theory KW - Micromagnetic simulation KW - Nonequilibrium dynamics Y1 - 2021 SN - 2079-4991 U6 - https://doi.org/10.3390/nano11051257 N1 - This article belongs to the Special Issue Applications and Properties of Magnetic Nanoparticles VL - 11 IS - 5 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - JOUR A1 - Aliazizi, Fereshteh A1 - Özsoylu, Dua A1 - Bakhshi Sichani, Soroush A1 - Khorshid, Mehran A1 - Glorieux, Christ A1 - Robbens, Johan A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures JF - Micromachines N2 - In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems. KW - chip-based sensor setup KW - aquaculture KW - microfluidics KW - impedance spectroscopy KW - thermometry KW - electrical conductivity of liquids Y1 - 2024 U6 - https://doi.org/10.3390/mi15060755 SN - 2072-666X N1 - This article belongs to the Special Issue "Multisensor Arrays" N1 - Corresponding author: Michael J. Schöning VL - 15 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Zhantlessova, Sirina A1 - Savitskaya, Irina A1 - Kistaubayeva, Aida A1 - Ignatova, Ludmila A1 - Talipova, Aizhan A1 - Pogrebnjak, Alexander A1 - Digel, Ilya T1 - Correction: Zhantlessova et al. advanced “Green” prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy. Polymers 2022, 14, 3224 JF - Polymers Y1 - 2024 U6 - https://doi.org/10.3390/polym16131802 SN - 2073-4360 N1 - This article belongs to the Special Issue Cellulose Based Composites VL - 16 IS - 13 PB - MDPI CY - Basel ER -