TY - CHAP A1 - Evers, Jörg A1 - Fleischhaker, Robert A1 - Pálffy, A. A1 - Keitel, C. T1 - Light propagation : From atomic to nuclear quantum optics T2 - Modern optics and photonics: atoms and structured media Y1 - 2010 SN - 978-981431327-8 U6 - https://doi.org/10.1142/9789814313278_0001 SP - 3 EP - 15 PB - World Scientific Publishing Co. ER - TY - CHAP A1 - Pasligh, N. A1 - Funke, D. A1 - Röth, Thilo A1 - Krack, R. T1 - Leichtbau Quertrager als Stahlblech-Aluminiumdruckguss-Hybrid - Von der numerischen Berechnung bis zum realen Prototypen T2 - VDI BERICHTE Y1 - 2010 SN - 978-3-18-092107-5 N1 - 15. Kongress SIMVEC Berechnung und Simulation im Fahrzeugbau, Baden-Baden, 16. und 17. November 2010 PB - VDI Verlag CY - Düsseldorf ER - TY - BOOK A1 - Höhne, Tim T1 - Einflüsse von Make or Buy-Entscheidungen auf die Termintreue Y1 - 2010 SN - 978-3-940565-64-8 N1 - Ergebnisse aus der Produktionstechnik ; 2010,8 / Zugl.: Aachen, Techn. Hochsch., Diss., 2010 PB - Apprimus Verl. CY - Aachen ER - TY - JOUR A1 - Ross, Jillian A1 - Plummer, Simon M. A1 - Rode, Anja A1 - Scheer, Nico A1 - Bower, Conrad C. A1 - Vogel, Ortwin A1 - Henderson, Colin J. A1 - Wolf, C. Roland A1 - Elcombe, Clifford R. T1 - Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo JF - Toxicological Sciences N2 - Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel “humanized” and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained. Y1 - 2010 U6 - https://doi.org/10.1093/toxsci/kfq118 SN - 1096-0929 VL - 116 IS - 2 SP - 452 EP - 466 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Scheer, Nico A1 - Ross, Jillian A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Wolf, C. Roland T1 - In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice JF - Drug Metabolism and Disposition N2 - Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound. Y1 - 2010 U6 - https://doi.org/10.1124/dmd.109.031872 SN - 1521-009X VL - 38 IS - 7 SP - 1046 EP - 1053 PB - ASPET CY - Bethesda ER - TY - BOOK A1 - Matcha, Heike T1 - Therme mit Gästehaus : Masterentwurf WS 2009/2010 Y1 - 2010 SN - 978-3-88536-115-2 PB - Technische Universität Darmstadt CY - Darmstadt ER - TY - BOOK A1 - Matcha, Heike T1 - Konzerthaus in Stralsund : Masterentwurf SS 2009 Y1 - 2010 SN - 978-3-88536-114-5 PB - Technische Universität Darmstadt CY - Darmstadt ER - TY - BOOK A1 - Matcha, Heike T1 - Lamborghini an der Spree : Masterentwurf WS 2008/2009 Y1 - 2010 SN - 978-3-88536-113-8 PB - Technische Universität Darmstadt CY - Darmstadt ER - TY - BOOK A1 - Matcha, Heike A1 - Quasten, Gero A1 - Rabighomi, Hossein T1 - Qualitätssteigerung im verdichteten Wohnungsbau über Erzeugung größerer Vielfalt und Flexibilität durch individualisierte Massenfertigung am Beispiel gestapelter Reihenhäuser Y1 - 2010 SN - 978-3-8167-8216-2 PB - Fraunhofer IRB Verlag CY - Stuttgart ER - TY - CHAP A1 - Matcha, Heike ED - Hauschild, Moritz ED - Karzel, Rüdiger T1 - Regelbasierte Planung - Parametrik T2 - Digitale Prozesse: Planung, Gestaltung, Fertigung Y1 - 2010 SN - 978-3-920034-35-5 N1 - gedruckt in der Bereichsbibliothek Bayernallee unter der Signatur: 11 WTP 101 ; auch als Online-Ausgabe verfügbar SP - 24 EP - 24 PB - Ed. Detail CY - München ER - TY - CHAP A1 - Matcha, Heike ED - Hauschild, Moritz ED - Karzel, Rüdiger T1 - Regelbasierte Planung - Parametrik T2 - Digitale Prozesse : Planung, Gestaltung, Fertigung Y1 - 2010 SN - 978-3-95553-022-8 U6 - https://doi.org/10.11129/detail.9783955530228 N1 - auch gedruckt in der Bereichsbibliothek Bayernallee unter der Signatur 11 WTP 101 SP - 24 EP - 24 PB - Detail CY - München ER - TY - BOOK A1 - Matcha, Heike T1 - Expo 15 : Experimental Parametric Object ; Realisierung des Messestandes "Digital Origami" für den Fachbereich Architektur der Technischen Universität Darmstadt Y1 - 2010 PB - Technische Universität Darmstadt CY - Darmstadt ER - TY - CHAP A1 - Matcha, Heike A1 - Ljubas, Ante T1 - Parametric Origami: Adaptable temporary buildings T2 - Future cities: 28th eCAADe Conference Proceedings. eCAADe: Conferences. Zurich, Switzerland Y1 - 2010 SN - 978-0-9541183-7-2 SP - 243 EP - 251 ER - TY - RPRT A1 - Temiz Artmann, Aysegül T1 - Frühgeburtenrate mindern durch ein Prognoseverfahren für den vorzeitigen Blasensprung - PROMPT (Premature rupture of membranes prediction test) : Abschlussbericht ; Laufzeit des Vorhabens: 01.03.2007 - 31.12.2009 Y1 - 2010 U6 - https://doi.org/10.2314/GBV:644277858 N1 - Förderkennzeichen BMBF 1772X07 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Aachen ER - TY - CHAP A1 - Bitz, Andreas A1 - Kraff, O. A1 - Orzada, S. A1 - Maderwald, S. A1 - Brote, I. A1 - Ladd, M. T1 - Experimental and Numerical Assessment of RF Safety of Transmit Coils at 7 Tesla T2 - ISMRM workshop on MR safety 2010 : RF heating of the human in MRI : workshop series. The Washington County Historic Courthouse, Stillwater, Minnesota, USA, 15 - 17 October 2010 Y1 - 2010 SN - 978-1-62276-088-6 SP - 195 ER - TY - JOUR A1 - Paulßen, Elisabeth A1 - Schweighöfer, Philip V. A1 - Abram, Ulrich T1 - Reactions of [ReOX3(PPh3)2] Complexes (X = Cl, Br) with Phenylacetylene and the Structures of the Products JF - Zeitschrift für anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry N2 - Oxorhenium(V) complexes [ReOX3(PPh3)2] (X = Cl, Br) react with phenylacetylene under formation of complexes with ylide-type ligands. Compounds of the compositions [ReOCl3(PPh3){C(Ph)C(H)(PPh3)}] (1), [ReOBr3(OPPh3){C(Ph)C(H)(PPh3)}] (2), and [ReOBr3(OPPh3){C(H)C(Ph)(PPh3)}] (3) were isolated and characterized by X-ray diffraction. They contain a ligand, which was formed by a nucleophilic attack of released PPh3 at coordinated phenylacetylene. The structures of the products show that there is no preferable position for this attack. Cleavage of the Re–C bond in 3 and dimerization of the organic ligand resulted in the formation of the [{(PPh3)(H)CC(Ph)}2]2+ cation, which crystallized as its [(ReOBr4)(OReO3)]2– salt. Y1 - 2010 U6 - https://doi.org/10.1002/zaac.200900478 SN - 1521-3749 VL - 636 IS - 5 SP - 779 EP - 783 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Paulßen, Elisabeth A1 - Alberto, Roger A1 - Abram, Ulrich T1 - Synthesis, Characterization, and Structures of R3EOTcO3 Complexes (E = C, Si, Ge, Sn, Pb) and Related Compounds JF - Inorganic Chemistry N2 - AgTcO4 reacts with R3ECl compounds (E = C, Si, Ge, Sn, Pb; R = Me, iPr, tBu, Ph), tBu2SnCl2, or PhMgCl under formation of novel trioxotechnetium(VII) derivatives. The carbon and silicon derivatives readily undergo decomposition, which was proven by 99Tc NMR spectroscopy and the isolation of decomposition products such as [TcOCl3(THF)(OH2)]. Compounds [Ph3GeOTcO3], [(THF)Ph3SnOTcO3], [(O3TcO)SntBu2(OH)]2, and [(THF)4Mg(OTcO3)2] are more stable and were isolated in crystalline form and characterized by X-ray diffraction. Y1 - 2010 U6 - https://doi.org/10.1021/ic1001094 SN - 1520-510X VL - 49 IS - 7 SP - 3525 EP - 3530 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Barbazán, Paula A1 - Hagenbach, Adelheid A1 - Paulßen, Elisabeth A1 - Abram, Ulrich A1 - Carballo, Rosa A1 - Rodriguez-Hermida, Sabina A1 - Vázquez-López, Ezequiel M. T1 - Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5-Diazafluoren-9-one and 1,10-Phenanthroline-5,6-dione JF - European Journal of Inorganic Chemistry N2 - Tricarbonylrhenium(I) and -technetium(I) halide (halide = Cl and Br) complexes of ligands derived from 4,5-diazafluoren-9-one (df) and 1,10-phenanthroline-5,6-dione (phen) derivatives of benzoic and 2-hydroxybenzoic acid hydrazides have been prepared. The complexes have been characterized by elemental analysis, MS, IR, 1H NMR and absorption and emission UV/Vis spectroscopic methods. The metal centres (ReI and TcI) are coordinated through the nitrogen imine atoms and establish five-membered chelate rings, whereas the hydrazone groups stand uncoordinated. The 1H NMR spectra suggest the same behaviour in solution on the basis of only marginal variations in the chemical shifts of the hydrazine protons. Y1 - 2010 U6 - https://doi.org/10.1002/ejic.201000522 SN - 1099-0682 IS - 29 SP - 4622 EP - 4630 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Wilke, Thomas ED - Heussler, Carla T1 - Piemont – Grenzregion zwischen Frankreich und Italien T2 - Sehnsucht Italien – Die schönsten Kunstlandschaften von Piemont bis Sizilien Y1 - 2010 SN - 978-3-534-22986-4 SP - 13 EP - 24 PB - WBG CY - Darmstadt ER - TY - CHAP A1 - Wilke, Thomas ED - Castor, Markus A. T1 - Vorlagegraphik versus Künstlergraphik: Überlegungen zu Jean Lepautres Kupferstichfolgen für die Innenraumgestaltung T2 - Druckgraphik : zwischen Reproduktion und Invention Y1 - 2010 SN - 978-3-422-06940-4 N1 - Passagen ; 31 SP - 419 EP - 432 PB - Dt. Kunstverl. CY - Berlin ER -