TY  - JOUR
A1  - Bronder, Thomas
A1  - Jessing, Max P.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors
JF  - Analytical Chemistry
N2  - Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.
Y1  - 2018
U6  - https://doi.org/10.1021/acs.analchem.8b01807
SN  - 0003-2700
VL  - 90
IS  - 12
SP  - 7747
EP  - 7753
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Ditzhaus, Marc
A1  - Gaigall, Daniel
T1  - A consistent goodness-of-fit test for huge dimensional and functional data
JF  - Journal of Nonparametric Statistics
N2  - A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cramér-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals.
KW  - Cramér-von-Mises statistic
KW  - separable Hilbert space
KW  - huge dimensional data
KW  - functional data
Y1  - 2018
U6  - https://doi.org/10.1080/10485252.2018.1486402
SN  - 1029-0311
VL  - 30
IS  - 4
SP  - 834
EP  - 859
PB  - Taylor & Francis
CY  - Abingdon
ER  - 
TY  - GEN
A1  - Ross-Jones, J.
A1  - Teumer, T.
A1  - Capitain, C.
A1  - Tippkötter, Nils
A1  - Krause, M. J.
A1  - Methner, F.-J.
A1  - Rädle, M.
T1  - Analytical methods for in-line characterization of beer haze
T2  - Trends in Brewing
N2  - In most beers, producers strive to minimize haze to maximize visual appeal. To detect the formation of particulates, a measurement system for sub-micron particles is required. Beer haze is naturally occurring, composed of protein or polyphenol particles; in their early stage of growth their size is smaller than 2 µm. Microscopy analysis is time and resource intensive; alternatively, backscattering is an inexpensive option for detecting particle sizes of interest.
Y1  - 2018
N1  - Trends in Brewing, April 8 –12, 2018, Ghent, Belgium
ER  - 
TY  - CHAP
A1  - Finkenberger, Isabel Maria
T1  - Die Stadt als städtisch-theatrale Versuchsanordnung: Wie wollen wir in Zukunft leben und welche Stadt brauchen wir dafür?
T2  - Un/Certain Futures - Rollen des Designs in gesellschaftlichen Transformationsprozessen
Y1  - 2024
SN  - 9783839443323
U6  - https://doi.org/https://doi.org/10.1515/9783839443323-009
SP  - 86
EP  - 95
PB  - transcript
CY  - Bielefeld
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Oberländer, Jan
A1  - Kirchner, Patrick
A1  - Keusgen, Michael
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Experimental and Numerical Analyzes of a Sensor Based on Interdigitated Electrodes for Studying Microbiological Alterations
JF  - physica status solidi (a): applications and materials science
N2  - In this work, a cell-based biosensor to evaluate the sterilization efficacy of hydrogen peroxide vapor sterilization processes is characterized. The transducer of the biosensor is based on interdigitated gold electrodes fabricated on an inert glass substrate. Impedance spectroscopy is applied to evaluate the sensor behavior and the alteration of test microorganisms due to the sterilization process. These alterations are related to changes in relative permittivity and electrical conductivity of the bacterial spores. Sensor measurements are conducted with and without bacterial spores (Bacillus atrophaeus), as well as after an industrial sterilization protocol. Equivalent two-dimensional numerical models based on finite element method of the periodic finger structures of the interdigitated gold electrodes are designed and validated using COMSOL® Multiphysics software by the application of known dielectric properties. The validated models are used to compute the electrical properties at different sensor states (blank, loaded with spores, and after sterilization). As a final result, we will derive and tabulate the frequency-dependent electrical parameters of the spore layer using a novel model that combines experimental data with numerical optimization techniques.
Y1  - 2018
U6  - https://doi.org/10.1002/pssa.201700920
SN  - 1862-6319
VL  - 215
IS  - 15
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - BOOK
A1  - Laack, Walter van
T1  - Sterben und Tod aus wissenschaftlicher Sicht - dying and death from a scientific point of view
Y1  - 2018
SN  - 978-3-936624-41-0
PB  - van Laack GmbH
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Kurz, Melanie
T1  - Was heißt: Verantwortung im Design? Historische Positionen
JF  - Boxhorn: das Magazin aus dem Fachbereich Gestaltung der FH Aachen
Y1  - 2018
IS  - 34
SP  - 26
EP  - 33
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Baringhaus, Ludwig
A1  - Gaigall, Daniel
T1  - Efficiency comparison of the Wilcoxon tests in paired and independent survey samples
JF  - Metrika
N2  - The efficiency concepts of Bahadur and Pitman are used to compare the Wilcoxon tests in paired and independent survey samples. A comparison through the length of corresponding confidence intervals is also done. Simple conditions characterizing the dominance of a procedure are derived. Statistical tests for checking these conditions are suggested and discussed.
KW  - Wilcoxon tests
KW  - Pitman efficiency
KW  - Bahadur efficiency
KW  - Length of confidence intervals
KW  - Kernel density estimator
Y1  - 2018
U6  - https://doi.org/10.1007/s00184-018-0661-4
SN  - 1435-926X
VL  - 2018
IS  - 81
SP  - 891
EP  - 930
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Bernecker, Andreas
A1  - Klier, Julia
A1  - Stern, Sebastian
A1  - Thiel, Lea
T1  - Sustaining high performance beyond public-sector pilot projects.
Y1  - 2018
IS  - September 2018
ER  - 
TY  - JOUR
A1  - Hirsch, Marko
A1  - Kleeberg, Jochen
A1  - Schmitz, Philipp
T1  - Dynamische Asset-Allocation- Strategien im Niedrigzinsumfeld
JF  - Absolut|report : neue Perspektiven für institutionelle Investoren
Y1  - 2018
IS  - 6
SP  - 52
PB  - Absolut Research
CY  - Hamburg
ER  - 
TY  - JOUR
A1  - Valero, Daniel
A1  - Bung, Daniel Bernhard
A1  - Crookston, B.M.
T1  - Energy dissipation of a Type III basin under design and adverse conditions for stepped and smooth spillways
JF  - Journal of Hydraulic Engineering
N2  - New information regarding the influence of a stepped chute on the hydraulic performance of the United States Bureau of Reclamation (Reclamation) Type III hydraulic jump stilling basin is presented for design (steady) and adverse (decreasing tailwater) conditions. Using published experimental data and computational fluid dynamics (CFD) models, this paper presents a detailed comparison between smooth-chute and stepped-chute configurations for chute slopes of 0.8H:1V and 4H:1V and Froude numbers (F) ranging from 3.1 to 9.5 for a Type III basin designed for F = 8. For both stepped and smooth chutes, the relative role of each basin element was quantified, up to the most hydraulic extreme case of jump sweep-out. It was found that, relative to a smooth chute, the turbulence generated by a stepped chute causes a higher maximum velocity decay within the stilling basin, which represents an enhancement of the Type III basin’s performance but also a change in the relative role of the basin elements. Results provide insight into the ability of the CFD models [unsteady Reynolds-averaged Navier-Stokes (RANS) equations with renormalization group (RNG) k-ϵ turbulence model and volume-of-fluid (VOF) for free surface tracking] to predict the transient basin flow structure and velocity profiles. Type III basins can perform adequately with a stepped chute despite the effects steps have on the relative role of each basin element. It is concluded that the classic Type III basin design, based upon methodology by reclamation specific to smooth chutes, can be hydraulically improved for the case of stepped chutes for design and adverse flow conditions using the information presented herein.
Y1  - 2018
U6  - https://doi.org/10.1061/(ASCE)HY.1943-7900.0001482
SN  - 0733-9429
N1  - Article number 04018036
VL  - 144
IS  - 7
PB  - ASCE
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Teumer, T.
A1  - Capitain, C.
A1  - Ross-Jones, J.
A1  - Tippkötter, Nils
A1  - Rädle, M.
A1  - Methner, F.-J.
T1  - In-line Haze Monitoring Using a Spectrally Resolved Back Scattering Sensor
JF  - BrewingScience
N2  - In the present work an optical sensor in combination with a spectrally resolved detection device for in-line particle-size-monitoring for quality control in beer production is presented. The principle relies on the size and wavelength dependent backscatter of growing particles in fluids. Measured interference structures of backscattered light are compared with calculated theoretical values, based on Mie-Theory, and fitted with a linear least square method to obtain particle size distributions. For this purpose, a broadband light source in combination with a process-CCD-spectrometer (charge ? coupled device spectrometer) and process adapted fiber optics are used. The goal is the development of an easy and flexible measurement device for in-line-monitoring of particle size. The presented device can be directly installed in product fill tubes or vessels, follows CIP- (cleaning in place) and removes the need of sample taking. A proof of concept and preliminary results, measuring protein precipitation, are presented.
Y1  - 2018
SN  - 1613-2041
VL  - 71
IS  - 5/6
SP  - 49
EP  - 55
PB  - Fachverlag Hans Carl
CY  - Nürnberg
ER  - 
TY  - BOOK
A1  - Golland, Alexander
A1  - Koglin, Olaf
T1  - Kirchliches Datenschutzrecht: Datenschutz-Grundverordnung, Datenschutzvorschriften der Kirchen in Deutschland und Durchführungsverordnungen / herausgegeben von Alexander Golland und Olaf Koglin
N2  - Textsammlung mit allen für den Datenschutz in Kirchen maßgeblichen Regelwerken: DSGVO, KDG, KDR-OG und DSG-EKD sowie begleitende Verordnungen KDO-DVO und ITSVO-EKD. Die vorliegende Textsammlung enthält neben dem zentralen Regelwerk, der Datenschutz-Grundverordnung (DSGVO) in ihrer letzten korrigierten Fassung vom 19. April 2018, die Normen des kirchlichen Rechts, die aufgrund der DSGVO neu erlassen wurden. Auf Seiten der katholischen Kirche sind dies das Gesetz über den Kirchlichen Datenschutz (KDG) und die Kirchliche Datenschutzregelung der Ordensgemeinschaft päpstlichen Rechts (KDR-OG); zudem findet die Verordnung zur Durchführung der Anordnung über den kirchlichen Datenschutz (KDO-DVO) weiterhin entsprechende Anwendung. Die evangelische Kirche novellierte das Kirchengesetz über den Datenschutz der Evangelischen Kirche in Deutschland (DSG-EKD) und hielt an der Verordnung zur Sicherheit der Informationstechnik (ITSVO-EKD) fest. Ergänzt wird das Werk durch Verweise auf maßgebliche Veröffentlichungen der Artikel-29-Datenschutzgruppe und der weltlichen und kirchlichen Datenschutzaufsichtsbehörden. Damit richtet sich das vorliegende Werk vor allem an kirchliche Gemeinden sowie Unternehmen in kirchlicher Trägerschaft und ihre Datenschutzbeauftragten wie gleichermaßen an private Unternehmen, Kanzleien und Berater mit kirchlicher Kundschaft bzw. Mandantschaft.
Y1  - 2018
SN  - 978-1-7210-2406-3
PB  - Createspace Independent Publishing Platform
CY  - North Charleston
ET  - 1. Auflage
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
A1  - Poghossian, Arshak
A1  - Miyamoto, K.I.
A1  - Werner, C.F.
A1  - Krause, S.
A1  - Yoshinobu, T.
T1  - Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging
T2  - Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7
Y1  - 2018
SN  - 9780128097397
SP  - 295
EP  - 308
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Valero, Daniel
A1  - Bung, Daniel Bernhard
T1  - Vectrino profiler spatial filtering for shear flows based on the mean velocity gradient equation
JF  - Journal of Hydraulic Engineering
N2  - A new methodology is proposed to spatially filter acoustic Doppler velocimetry data from a Vectrino profiler based on the differential mean velocity equation. Lower and upper bounds are formulated in terms of physically based flow constraints. Practical implementation is discussed, and its application is tested against data gathered from an open-channel flow over a stepped macroroughness surface. The method has proven to detect outliers occurring all over the distance range sampled by the Vectrino profiler and has shown to remain applicable out of the region of validity of the velocity gradient equation. Finally, a statistical analysis suggests that physically obtained bounds are asymptotically representative.
Y1  - 2018
U6  - https://doi.org/10.1061/(ASCE)HY.1943-7900.0001485
SN  - 0733-9429
N1  - Article number 04018037
VL  - 144
IS  - 7
PB  - ASCE
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
T1  - ERIKA—Early Robotics Introduction at Kindergarten Age
JF  - Multimodal Technologies Interact
N2  - In this work, we report on our attempt to design and implement an early introduction to basic robotics principles for children at kindergarten age. One of the main challenges of this effort is to explain complex robotics contents in a way that pre-school children could follow the basic principles and ideas using examples from their world of experience. What sets apart our effort from other work is that part of the lecturing is actually done by a robot itself and that a quiz at the end of the lesson is done using robots as well. The humanoid robot Pepper from Softbank, which is a great platform for human–robot interaction experiments, was used to present a lecture on robotics by reading out the contents to the children making use of its speech synthesis capability. A quiz in a Runaround-game-show style after the lecture activated the children to recap the contents they acquired about how mobile robots work in principle. In this quiz, two LEGO Mindstorm EV3 robots were used to implement a strongly interactive scenario. Besides the thrill of being exposed to a mobile robot that would also react to the children, they were very excited and at the same time very concentrated. We got very positive feedback from the children as well as from their educators. To the best of our knowledge, this is one of only few attempts to use a robot like Pepper not as a tele-teaching tool, but as the teacher itself in order to engage pre-school children with complex robotics contents.
Y1  - 2018
U6  - https://doi.org/10.3390/mti2040064
SN  - 2414-4088
VL  - 2
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schwabedal, Justus T. C.
A1  - Sippel, Daniel
A1  - Brandt, Moritz D.
A1  - Bialonski, Stephan
T1  - Automated Classification of Sleep Stages and EEG Artifacts in Mice with Deep Learning
N2  - Sleep scoring is a necessary and time-consuming task in sleep studies. In animal models (such as mice) or in humans, automating this tedious process promises to facilitate long-term studies and to promote sleep biology as a data-driven f ield. We introduce a deep neural network model that is able to predict different states of consciousness (Wake, Non-REM, REM) in mice from EEG and EMG recordings with excellent scoring results for out-of-sample data. Predictions are made on epochs of 4 seconds length, and epochs are classified as artifactfree or not. The model architecture draws on recent advances in deep learning and in convolutional neural networks research. In contrast to previous approaches towards automated sleep scoring, our model does not rely on manually defined features of the data but learns predictive features automatically. We expect deep learning models like ours to become widely applied in different fields, automating many repetitive cognitive tasks that were previously difficult to tackle.
Y1  - 2018
U6  - https://doi.org/10.48550/arXiv.1809.08443
ER  - 
TY  - CHAP
A1  - Hofmann, Till
A1  - Mataré, Victor
A1  - Neumann, Tobias
A1  - Schönitz, Sebastian
A1  - Henke, Christoph
A1  - Limpert, Nicolas
A1  - Niemueller, Tim
A1  - Ferrein, Alexander
A1  - Jeschke, Sabina
A1  - Lakemeyer, Gerhard
T1  - Enhancing Software and Hardware Reliability for a Successful Participation in the RoboCup Logistics League 2017
Y1  - 2018
SN  - 978-3-030-00308-1
U6  - https://doi.org/10.1007/978-3-030-00308-1_40
N1  - Lecture Notes in Computer Science, vol 11175
SP  - 486
EP  - 497
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Bhattarai, Aroj
A1  - Staat, Manfred
ED  - Artmann, Gerhard
ED  - Temiz Artmann, Aysegül
ED  - Zhubanova, Azhar A.
ED  - Digel, Ilya
T1  - Mechanics of soft tissue reactions to textile mesh implants
T2  - Biological, Physical and Technical Basics of Cell Engineering
N2  - For pelvic floor disorders that cannot be treated with non-surgical procedures, minimally invasive surgery has become a more frequent and safer repair procedure. More than 20 million prosthetic meshes are implanted each year worldwide. The simple selection of a single synthetic mesh construction for any level and type of pelvic floor dysfunctions without adopting the design to specific requirements increase the risks for mesh related complications. Adverse events are closely related to chronic foreign body reaction, with enhanced formation of scar tissue around the surgical meshes, manifested as pain, mesh erosion in adjacent structures (with organ tissue cut), mesh shrinkage, mesh rejection and eventually recurrence. Such events, especially scar formation depend on effective porosity of the mesh, which decreases discontinuously at a critical stretch when pore areas decrease making the surgical reconstruction ineffective that further augments the re-operation costs. The extent of fibrotic reaction is increased with higher amount of foreign body material, larger surface, small pore size or with inadequate textile elasticity. Standardized studies of different meshes are essential to evaluate influencing factors for the failure and success of the reconstruction. Measurements of elasticity and tensile strength have to consider the mesh anisotropy as result of the textile structure. An appropriate mesh then should show some integration with limited scar reaction and preserved pores that are filled with local fat tissue. This chapter reviews various tissue reactions to different monofilament mesh implants that are used for incontinence and hernia repairs and study their mechanical behavior. This helps to predict the functional and biological outcomes after tissue reinforcement with meshes and permits further optimization of the meshes for the specific indications to improve the success of the surgical treatment.
Y1  - 2018
SN  - 978-981-10-7904-7
U6  - https://doi.org/10.1007/978-981-10-7904-7_11
SP  - 251
EP  - 275
PB  - Springer
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Hüning, Felix
A1  - Heuermann, Holger
A1  - Wache, Franz-Josef
T1  - Wireless CAN
T2  - Tagungsband AALE 2018 : das Forum für Fachleute der Automatisierungstechnik aus Hochschulen und Wirtschaft ; 15. Fachkonferenz, Regensburg ; [15. Konferenz für Angewandte Automatisierungstechnik in Lehre und Entwicklung / TH Köln; VFAALE, Verein der Freunde und Förderer der Angewandten Automatisierungstechnik]
N2  - Das vorgestellte System zu Wireless CAN bietet die Möglichkeit, CAN kabellos zu übertragen. Beide vorgestellten und entwickelten Konzepte funktionieren korrekt und ermöglichen den Auf-bau von kabellosen CAN Schnittstellen. Durch den kleinen Aufbau kann diese Technologie auch für eingebettete Systeme verwendet werden. Zudem bietet dieser Ansatz die Möglichkeit, durch die Entwicklung von geeigneten ICs die Größe des Systems bis auf Bauteilgröße zu reduzieren, um eine noch bessere Integration in eingebettete Systeme zu ermöglichen. Dadurch wird die Technologie attraktiv für Einsatzgebiete, wo die oben aufgelisteten Vorteile zum Tragen kommen können. Diese Einsatzgebiete können sowohl im Automobil als auch im Industriebereich liegen.
Y1  - 2018
SP  - 135
EP  - 144
PB  - VDE Verlag
ER  -