TY  - JOUR
A1  - Sadykov, Rustam
A1  - Digel, Ilya
A1  - Temiz Artmann, Aysegül
A1  - Porst, Dariusz
A1  - Linder, Peter
A1  - Kayser, Peter
A1  - Artmann, Gerhard
A1  - Savitskaya, Irina
A1  - Zhubanova, Azhar
T1  - Oral lead exposure induces dysbacteriosis in rats
JF  - Journal of Occupational Health. 51 (2009) (2009), H. 1
Y1  - 2009
SN  - 1348-9585
SP  - 64
EP  - 73
ER  - 
TY  - CHAP
A1  - Sajatovic, Miodrag
A1  - Rihacek, Christoph
A1  - Haindl, Bernhard
A1  - Schnell, Michael
A1  - Brandes, Sinja
A1  - Gligorevic, Snjezana
T1  - Broadband VHF (B-VHF) project achievements and follow-on activities
T2  - Integrated Communications, Navigation and Surveillance Conference : Herndon, VA, 1 - 3 May 2007
Y1  - 2007
SN  - 1-4244-1216-1
SP  - 1
EP  - 8
ER  - 
TY  - CHAP
A1  - Sakthivel, Mariappan
A1  - Weppner, Werner
T1  - Response behaviour of a hydrogen sensor based on ionic conducting polymer-metal interfaces prepared by the chemical reduction method
N2  - A solid-state amperometric hydrogen sensor based on a protonated Nafion membrane and catalytic active electrode operating at room temperature was fabricated and tested. Ionic conducting polymer-metal electrode interfaces were prepared chemically by using the impregnation-reduction method. The polymer membrane was impregnated with tetra-ammine platinum chloride hydrate and the metal ions were subsequently reduced by using either sodium tetrahydroborate or potassium tetrahydroborate. The hydrogen sensing characteristics with air as reference gas is reported. The sensors were capable of detecting hydrogen concentrations from 10 ppm to 10% in nitrogen. The response time was in the range of 10-30 s and a stable linear current output was observed. The thin Pt films were characterized by XRD, Infrared Spectroscopy, Optical Microscopy, Atomic Force Microscopy, Scanning Electron Microscopy and EDAX.
KW  - Biosensor
KW  - Hydrogen sensor
KW  - amperometric sensor
KW  - porous Pt electrode
KW  - chemical reduction method
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1399
ER  - 
TY  - JOUR
A1  - Salpati, Laurent
A1  - Chu, Xiaoyan
A1  - Chen, Liangfu
A1  - Prasad, Bhagwat
A1  - Dallas, Shannon
A1  - Evers, Raymond
A1  - Mamaril-Fishman, Donna
A1  - Geier, Ethan G.
A1  - Kehler, Jonathan
A1  - Kunta, Jeevan
A1  - Mezler, Mario
A1  - Laplanche, Loic
A1  - Pang, Jodie
A1  - Soars, Matthew G.
A1  - Unadkat, Jashvant D.
A1  - van Waterschoot, Robert A.B.
A1  - Yabut, Jocelyn
A1  - Schinkel, Alfred H.
A1  - Scheer, Nico
A1  - Rode, Anja
T1  - Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins
JF  - Drug Metabolism and Disposition
N2  - Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography–tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.
Y1  - 2014
U6  - https://doi.org/10.1124/dmd.114.057976
SN  - 1521-009X
VL  - 42
IS  - 8
SP  - 1301
EP  - 1313
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Samm, Doris
T1  - DUMAND and the search for high energy neutrino point sources / Samm, Doris [u.a.]
JF  - Trends in astroparticle physics / ed. by Peter Christian Bosetti
Y1  - 1994
SN  - 3-8154-3017-8
N1  - (Teubner-Texte zur Physik; Bd. 28); International Conference on Trends in Astroparticle-Physics ; (2 : ;
SP  - 9
EP  - 20
PB  - Teubner
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Bosetti, P.-C.
T1  - Testmessungen an einem grossflaechigen (Durchmesser 35 cm) Photomultiplier Test measurements of a large-area (diameter 35 cm) photomultiplier / Bosetti, P.-C.; ... Samm, D. [u.a.]
JF  - Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1
Y1  - 1990
N1  - Fruehjahrstagung des Fachausschusses Teilchenphysik der Deutschen Physikalischen Gesellschaft e.V. (DPG), Hamburg (Germany), 21-24 Mar 1990
SP  - 33
EP  - 33
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Bosetti, P.-C.
T1  - DUMAND und die Suche nach extraterrestrischen Neutrinos / DUMAND and the search for extraterrestrial neutrinos / Bosetti, P.-C.; ... Samm, D. [u.a.]
JF  - Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1
Y1  - 1990
N1  - Fruehjahrstagung des Fachausschusses Teilchenphysik der Deutschen Physikalischen Gesellschaft e.V. (DPG), Hamburg (Germany), 21-24 Mar 1990
SP  - 88
EP  - 88
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Frenzel, E.
A1  - Heinrigs, W.
T1  - Limit on axion decay into an electron pair / H. Faissner, E. Frenzel, W. Heinrigs, A. Preussger, D. Samm und U. Samm
JF  - Physics Letters B. Vol. 96 (1980), H. Issues 1-2
Y1  - 1980
SP  - 201
EP  - 205
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Frenzel, E.
A1  - Heinrigs, W.
T1  - Observation of the two-photon decay of a light penetrating particle / H. Faissner, E. Frenzel, W. Heinrigs, A. Preussger, D. Samm und U. Samm
JF  - Physics Letters B. Vol. 103 (1980), H. Issues 3
Y1  - 1980
SP  - 234
EP  - 240
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Göttlicher, P.
A1  - Matela, H.
T1  - Search for scalar and pseudoscalar bosons emitted in nuclear decays via their interactions / Faissner, H.; Goettlicher, P. ; Matela, H. ; Samm, D.
JF  - Zeitschrift für Physik A Hadrons and Nuclei. 341 (1992), H. 3
Y1  - 1992
SP  - 359
EP  - 364
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Heinrigs, W.
A1  - Preussger, A.
T1  - Search for the two-photon decay of a light penetrating particle from a 590 MeV proton beam dump / Faissner, H.; Heinrigs, W.; Preussger, A.; Reitz, J.; Samm, D. [u.a.]
JF  - Zeitschrift für Physik, C Particles and Fields. 44 (1989), H. 4
Y1  - 1989
SP  - 557
EP  - 566
ER  - 
TY  - BOOK
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Henrigs, W.
A1  - Preussger, A.
T1  - Further evidence for the radiative decay of a light, penetrating particle / Faissner, H. ;  Heinrigs, W. ; Preussger, A. ;  Samm, D.
Y1  - 1982
N1  - Also published in INIS-mf--9311
PB  - Technische Hochschule
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Moers, T.
A1  - Priem, R.
T1  - Modular wall-less drift chamber for muon detection at the LHC / H. Faissner, Th. Moers, R. Priem, ... , D. Samm [u.a.]
JF  - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 330 (1993), H. 1-2
Y1  - 1993
SP  - 76
EP  - 82
ER  - 
TY  - CHAP
A1  - Samuelsson, K.
A1  - Scheer, Nico
A1  - Wilson, I.
A1  - Wolf, C.R.
A1  - Henderson, C.J.
ED  - Chackalamannil, Samuel
T1  - Genetically Humanized Animal Models
T2  - Comprehensive Medicinal Chemistry III. 3rd Edition
N2  - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
KW  - Chimeric liver-humanized mice
KW  - Drug distribution
KW  - Drug metabolism
KW  - Toxicology
KW  - Knockout mice
Y1  - 2017
SN  - 978-0-12-803201-5
U6  - https://doi.org/10.1016/B978-0-12-409547-2.12376-5
SP  - 130
EP  - 149
PB  - Elsevier
CY  - Saint Louis
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Design and evaluation of a bandwidth broker that provides network quality of service for grid applications
Y1  - 2003
SN  - 3-00-010002-4
N1  - NIC series ; 16 ; Zugl. Aachen, Techn. Hochsch., Diss., 2002
PB  - John von Neumann Institute for Computing (NIC)
CY  - Jülich
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Optical Network Infrastructure for Grid / Simeonidou, Dimitra ... (ed.)
Y1  - 2004
N1  - GFD-I.036 Category: Informational ; GHPN-RG
PB  - Global Grid Forum
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Networking Issues for Grid Infrastructure / Sander, Volker  (ed.)
Y1  - 2004
N1  - GFD-I.037 Category: Informational ; Grid High Performance Networking Research Group
PB  - Global Grid Forum
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Czajkowski, K.
A1  - Foster, I.
A1  - Kesselman, C.
T1  - SNAP: A Protocol for Negotiating Service Level Agreements and Coordinating Resource Management in Distributed Systems / Czajkowski, K. ; Foster, I. ; Kesselman, C. ; Sander, V. ; Tuecke, S.
JF  - Job Scheduling Strategies for Parallel Processing : 8th InternationalWorkshop, JSSPP 2002 Edinburgh, Scotland, UK, July 24, 2002. Revised Papers
Y1  - 2002
SN  - 3-540-00172-7
N1  - Lecture Notes in Computer Science ; 2537 ; JSSPP <8, 2002, Edinburgh >
SP  - 153
EP  - 183
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Erwin, Dietmar
A1  - Huber, Valentina
T1  - High-performance computer management based on Java
JF  - Future Generation Computer Systems. 15 (1999), H. 3
Y1  - 1999
SN  - 0167-739X
SP  - 425
EP  - 432
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Fidler, Markus
T1  - A parameter based admission control for differentiated services networks / Fidler, Markus ; Sander, Volker
JF  - Computer Networks. 44 (2004), H. 4
Y1  - 2004
SN  - 1389-1286
SP  - 463
EP  - 479
ER  -