TY  - JOUR
A1  - Wagner, Torsten
A1  - Miyamoto, K.
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
A1  - Yoshinobu, T.
T1  - Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS)
Y1  - 2011
U6  - http://dx.doi.org/10.1166/sl.2011.1620
VL  - 9
IS  - 2
SP  - 812
EP  - 815
PB  - American Scientific Publishers
CY  - Stevenson Ranch, Calif.
ER  - 
TY  - CHAP
A1  - Damm, Sebastian
A1  - Ritz, Thomas
A1  - Strauch, Jakob
T1  - Adaption of archetype patterns for mobile cloud-based business apps
T2  - 2011 IEEE International Conference on Pervasive Computing and Communications workshops (PerCom workshops 2011) : Seattle, Washington, USA, 21 - 25 March 2011
Y1  - 2011
SN  - 978-1-61284-938-6 (Print)
SN  - 978-1-61284-936-2 (E-Book)
U6  - http://dx.doi.org/10.1109/PERCOMW.2011.5766849
SP  - 100
EP  - 105
PB  - IEEE Service Center
CY  - Piscataway, NJ
ER  - 
TY  - CHAP
A1  - Fuchs, Britta
A1  - Ritz, Thomas
A1  - Halbach, Bastian
A1  - Hartl, Florian
ED  - Marca, David A.
T1  - Blended shopping : interactivity and individualization
T2  - Proceedings of the International Conference on e-Business : Seville, Spain, 18 - 21 July 2011 ; [... integrated in the ICETE (International Conference on e-Business and Telecommunications) joint conference]
Y1  - 2011
SN  - 978-989-8425-70-6
SP  - 47
EP  - 52
PB  - SciTePress
CY  - [Lissabon]
ER  - 
TY  - CHAP
A1  - Stieglitz, Kristian
A1  - Wollert, Jörg
T1  - Approach of using ultra-wideband-radio in industrial real-time ethernet networks
T2  - The 4th International Multi-Conference on Engineering and Technological Innovation : IMETI : July 19th - July 22nd, 2011, Orlando, Florida, USA
Y1  - 2011
SP  - 1
EP  - 6
ER  - 
TY  - JOUR
A1  - Raab, Monika
A1  - Kappel, Sven
A1  - Krämer, Andrea
A1  - Sanhaji, Mourad
A1  - Matthess, Yves
A1  - Kurunci-Csacsko, Elisabeth
A1  - Calzada-Wack, Julia
A1  - Rathkolb, Birgit
A1  - Rosman, Jan
A1  - Adler, Thure
A1  - Busch, Dirk H.
A1  - Esposito, Irene
A1  - Fuchs, Helmut
A1  - Gailus-Durner, Valérie
A1  - Klingenspor, Martin
A1  - Wolf, Eckhard
A1  - Sänger, Nicole
A1  - Prinz, Florian
A1  - Hrabe de Angelis, Martin
A1  - Seibler, Jost
A1  - Yuan, Juping
A1  - Bergmann, Martin
A1  - Knecht, Rainald
A1  - Kreft, Bertolt
A1  - Strebhardt, Klaus
T1  - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
JF  - Nature Communications
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncomms1395
SN  - 2041-1723
VL  - 2
IS  - 395
SP  - 1
EP  - 11
PB  - Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Hasegawa, Maki
A1  - Kapelyukh, Yury
A1  - Tahara, Harunobu
A1  - Seibler, Jost
A1  - Rode, Anja
A1  - Krueger, Sylvia
A1  - Lee, Dongtao N.
A1  - Wolf, C. Roland
A1  - Scheer, Nico
T1  - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
JF  - Molecular Pharmacology
Y1  - 2011
U6  - http://dx.doi.org/10.1124/mol.111.071845
SN  - 1521-0111
VL  - 80
IS  - 33
SP  - 518
EP  - 528
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Jordan, Sabine D.
A1  - Krüger, Markus
A1  - Willmes, Diana M.
A1  - Redemann, Nora
A1  - Wunderlich, F. Thomas
A1  - Brönneke, Hella S.
A1  - Merkwirth, Carsten
A1  - Kashkar, Hamid
A1  - Olkkonen, Vesa M.
A1  - Böttger, Thomas
A1  - Braun, Thomas
A1  - Seibler, Jost
A1  - Brüning, Jens C.
T1  - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
JF  - Nature Cell Biology
N2  - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Y1  - 2011
U6  - http://dx.doi.org/10.1038/ncb2211
SN  - 1465-7392
VL  - 13
IS  - 4
SP  - 434
EP  - 446
PB  - Nature
CY  - New York
ER  - 
TY  - JOUR
A1  - Inagaki, Akiko
A1  - Sleddens-Linkels, Esther
A1  - Wassenaar, Evelyne
A1  - Ooms, Marja
A1  - Cappellen, Wiggert A. van
A1  - Hoeijmakers, Jan H. J.
A1  - Seibler, Jost
A1  - Vogt, Thomas F.
A1  - Shin, Myung K.
A1  - Grootegoed, J. Anton
A1  - Baarends, Willy M.
T1  - Meiotic functions of RAD18
JF  - Journal of Cell Science
Y1  - 2011
U6  - http://dx.doi.org/10.1242/jcs.081968
SN  - 1477-9137
VL  - 124
IS  - 16
SP  - 2837
EP  - 2850
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - CHAP
A1  - Fissabre, Anke
A1  - Niethammer, Bernd
ED  - Graf, Franz
T1  - Early Glazed Curtain Walls and their Preservation
T2  - Il vetro nell’architettura del XX secolo : conservazione e restauro = Glass in the 20th Century Architecture : Preservation and Restoration
Y1  - 2011
SN  - 9788887624502
SP  - 185
EP  - 199
PB  - Mendrisio Academy Press
CY  - Mendrisio
ER  - 
TY  - JOUR
A1  - Mottaghy, Darius
A1  - Pechnig, Renate
A1  - Vogt, Christian
T1  - The geothermal project Den Haag: 3D numerical models for temperature prediction and reservoir simulation
JF  - Geothermics
N2  - The proposed Den Haag Zuidwest district heating system of the city of The Hague consists of a deep doublet in a Jurassic sandstone layer that is designed for a production temperature of 75 °C and a reinjection temperature of 40 °C at a flow rate of 150 m3 h−1. The prediction of reservoir temperature and production behavior is crucial for success of the proposed geothermal doublet. This work presents the results of a study of the important geothermal and geohydrological issues for the doublet design. In the first phase of the study, the influences of the three-dimensional (3D) structures of anticlines and synclines on the temperature field were examined. A comprehensive petrophysical investigation was performed to build a large scale 3D-model of the reservoir. Several bottomhole temperatures (BHTs), as well as petrophysical logs were used to calibrate the model using thermal conductivity measurements on 50 samples from boreholes in different lithological units in the study area. Profiles and cross sections extracted from the calculated temperature field were used to study the temperature in the surrounding areas of the planned doublet. In the second phase of the project, a detailed 3D numerical reservoir model was set up, with the aim of predicting the evolution of the producer and injector temperatures, and the extent of the cooled area around the injector. The temperature model from the first phase provided the boundary conditions for the reservoir model. Hydraulic parameters for the target horizons, such as porosity and permeability, were taken from data available from the nearby exploration wells. The simulation results are encouraging as no significant thermal breakthrough is predicted. For the originally planned location of the producer, the extracted water temperature is predicted to be around 79 °C, with an almost negligible cooling in the first 50 years of production. When the producer is located shallower parts of the reservoir, the yield water temperatures is lower, starting at ≈76 °C and decreasing to ≈74 °C after 50 years of operation. This comparatively larger decrease in temperature with time is caused by the structural feature of the reservoir, namely a higher dip causes the cooler water to easily move downward. In view of the poor reservoir data, the reservoir simulation model is constructed to allow iterative updates using data assimilation during planned drilling, testing, and production phases. Measurements during an 8 h pumping test carried out in late 2010 suggest that a flow rate of 150 m3 h−1 is achievable. Fluid temperatures of 76.5 °C were measured, which is very close to the predicted value.
Y1  - 2011
U6  - http://dx.doi.org/10.1016/j.geothermics.2011.07.001
SN  - 0375-6505
VL  - 40
IS  - 3
SP  - 199
EP  - 210
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Fleischhaker, Robert
A1  - Evers, Jörg
T1  - A Maxwell–Schrödinger solver for quantum optical few-level systems
JF  - Computer Physics Communications
N2  - The msprop program presented in this work is capable of solving the Maxwell–Schrödinger equations for one or several laser fields propagating through a medium of quantum optical few-level systems in one spatial dimension and in time. In particular, it allows to numerically treat systems in which a laser field interacts with the medium with both its electric and magnetic component at the same time. The internal dynamics of the few-level system is modeled by a quantum optical master equation which includes coherent processes due to optical transitions driven by the laser fields as well as incoherent processes due to decay and dephasing. The propagation dynamics of the laser fields is treated in slowly varying envelope approximation resulting in a first order wave equation for each laser field envelope function. The program employs an Adams predictor formula second order in time to integrate the quantum optical master equation and a Lax–Wendroff scheme second order in space and time to evolve the wave equations for the fields. The source function in the Lax–Wendroff scheme is specifically adapted to allow taking into account the simultaneous coupling of a laser field to the polarization and the magnetization of the medium. To reduce execution time, a customized data structure is implemented and explained. In three examples the features of the program are demonstrated and the treatment of a system with a phase-dependent cross coupling of the electric and magnetic field component of a laser field is shown.
Y1  - 2011
U6  - http://dx.doi.org/10.1016/j.cpc.2010.10.018
SN  - 0010-4655
VL  - 182
IS  - 3
SP  - 739
EP  - 747
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Park, Jin
A1  - El-Daib, Khaled
A1  - Butenweg, Christoph
A1  - Gellert, Christoph
T1  - A novel macroelement approach for masonry walls
T2  - Proceedings of the 8th International Conference on Structural Dynamics, EURODYN 2011 : Leuven, Belgium, 4 - 6 July 2011 / Katholieke Universiteit Leuven, ... G. De Roeck ... (eds)
Y1  - 2011
SN  - 978-90-76019-31-4
SP  - 3281
EP  - 3286
PB  - K. U. Leuven, Dep. of Civil Engineering
CY  - Leuven
ER  - 
TY  - CHAP
A1  - Reindl, Lukas
A1  - Butenweg, Christoph
A1  - Kubalski, Thomas
T1  - Numerical simulation of unreinforced masonry walls subject to dynamic out-of-plane loading
T2  - COMPDYN 2011 : ECCOMAS Thematic Conference ; Proceedings of the 3rd International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering ; 25-28 May, 2011, Corfu, Greece / Eds.: M. Papadrakakis ...
Y1  - 2011
SN  - 978-960-99994-0-3
SP  - 1
EP  - 10
PB  - National Technical Univ. of Athens
CY  - Athen
ER  - 
TY  - CHAP
A1  - Meskouris, Konstantin
A1  - Holtschoppen, Britta
A1  - Butenweg, Christoph
A1  - Rosin, Julia
T1  - Seismic analysis of liquid storage tanks
T2  - Earthquake Geology and Archaeology: Science, Society and Critical facilities : proceedings ; 2nd INQUA-IGCP 567 International Workshop on Active Tectonics, Earthquake Geology, Archaeology and Engineering ; 19-24 September 2011, Corinth (Greece) / Eds.: C. Grützner ; R. Pérez-Lopez ; T. Fernández Steeger ; I. Papanikolaou ; K. Reicherter ; P. G. Silva ; A. Vött. Volume 2
Y1  - 2011
SN  - 978-960-466-093-3
SP  - 136
EP  - 139
PB  - The Natural hazards Laboratory, National and Kapodistrian University of Athens
CY  - Athens
ER  - 
TY  - CHAP
A1  - Taddei, Francesca
A1  - Reindl, Lukas
A1  - Park, Jin
A1  - Butenweg, Christoph
A1  - Karadogan, Faruk
T1  - Numerical investigation of AAC wall panels based on the damage plasticity constitutive law
T2  - Cement, Wapno, Beton ; 2011, 7, Special issue: 5th International Conference on Autoclaved Aerated Concrete 'Securing a sustainable future' to be held at Bydgoszcz to celebrate 60 years of AAC experience in Poland, Bydgoszcz, September 14-17, 2011
Y1  - 2011
SN  - 1425-8129
SP  - 86
EP  - 91
PB  - Stowarzyszenie Producentów Cementu i Wapna
CY  - Krakow
ER  - 
TY  - JOUR
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Catala, Maria Moreno
A1  - Goldmann, Jan-Peter
A1  - Brüggemann, Gert-Peter
T1  - Lower leg musculoskeletal geometry and sprint performance
JF  - Gait and Posture
N2  - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.
Y1  - 2011
U6  - http://dx.doi.org/10.1016/j.gaitpost.2011.03.009
SN  - 0966-6362
VL  - 34
IS  - 1
SP  - 138
EP  - 141
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Umutlu, Lale
A1  - Orzada, Stephan
A1  - Kinner, Sonja
A1  - Maderwald, Stefan
A1  - Bronte, Irina
A1  - Bitz, Andreas
A1  - Kraff, Oliver
A1  - Ladd, Susanne C.
A1  - Antoch, Gerald
A1  - Ladd, Mark E.
A1  - Quick, Harald H.
A1  - Lauenstein, Thomas C.
T1  - Renal imaging at 7 Tesla: preliminary results
JF  - European Radiology
N2  - Objective
To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil.

Methods
In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists.

Results
Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers.

Conclusion
The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value.
Y1  - 2011
SN  - 1432-1084
VL  - 21
IS  - 4
SP  - 841
EP  - 849
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Orzada, Stephan
A1  - Bitz, Andreas
A1  - Schäfer, Lena C.
A1  - Ladd, Susanne C.
A1  - Ladd, Mark E.
A1  - Maderwald, Stefan
T1  - Open design eight-channel transmit/receive coil for high-resolution and real-time ankle imaging at 7 T
JF  - Medical Physics
N2  - Purpose:
At 1.5 T, real-time MRI of joint movement has been shown to be feasible. However, 7 T, provides higher SNR and thus an improved potential for parallel imaging acceleration. The purpose of this work was to build an open, U-shaped eight-channel transmit/receive microstrip coil for 7 T MRI to enable high-resolution and real-time imaging of the moving ankle joint.

Methods:
A U-shaped eight-channel transmit/receive array for the human ankle was built.urn:x-wiley:00942405:mp3399:equation:mp3399-math-0001-parameters and urn:x-wiley:00942405:mp3399:equation:mp3399-math-0002-factor were measured. SAR calculations of different ankle postures were performed to ensure patient safety. Inhomogeneities in the transmit field consequent to the open design were compensated for by the use of static RF shimming. High-resolution and real-time imaging was performed in human volunteers.

Results:
The presented array showed good performance with regard to patient comfort and image quality. High acceleration factors of up to 4 are feasible without visible acceleration artifacts. Reasonable image homogeneity was achieved with RF shimming.

Conclusions:
Open, noncylindrical designs for transmit/receive coils are practical at 7 T and real-time imaging of the moving joint is feasible with the presented coil design.
Y1  - 2011
U6  - http://dx.doi.org/10.1118/1.3553399
SN  - 2473-4209
VL  - 38
IS  - 3
SP  - 1162
EP  - 1167
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Kraff, Oliver
A1  - Bitz, Andreas
A1  - Breyer, Tobias
A1  - Kruszona, Stefan
A1  - Maderwald, Stefan
A1  - Brote, Irina
A1  - Gizewski, Elke R.
A1  - Ladd, Mark E.
A1  - Quick, Harald H.
T1  - A transmit/receive radiofrequency array for imaging the carotid arteries at 7 Tesla: coil design and first in vivo results
JF  - Investigative Radiology
N2  - Objective: 
To develop a transmit/receive radiofrequency (RF) array for magnetic resonance imaging (MRI) of the carotid arteries at 7 T. The prototype is characterized in numerical simulations and bench measurements, and the feasibility of plaque imaging at 7 T is demonstrated in first in vivo images.

Materials and Methods: 
The RF phased array coil consists of 8 surface loop coils. To allow imaging of both sides of the neck, the RF array is divided into 2 coil clusters, each with 4 overlapping loop elements. For safety validation, numerical computations of the RF field distribution and the corresponding specific absorption rate were performed on the basis of a heterogeneous human body model. To validate the coil model, maps of the transmit B1+ field were compared between simulation and measurement. In vivo images of a healthy volunteer and a patient (ulcerating plaque and a 50% stenosis of the right internal carotid artery) were acquired using a 3-dimensional FLASH sequence with a high isotropic spatial resolution of 0.54 mm as well as using pulse-triggered proton density (PD)/T2-weighted turbo spin echo sequences.

Results: 
Measurements of the S-parameters yielded a reflection and isolation of the coil elements of better than −18 and −13 dB, respectively. Measurements of the g-factor indicated good image quality for parallel imaging acceleration factors up to 2.4. A similar distribution and a very good match of the absolute values were found between the measured and simulated B1+ transmit RF field for the validation of the coil model. In vivo images revealed good signal excitation of both sides of the neck and a high vessel-to-background image contrast for the noncontrast-enhanced 3-dimensional FLASH sequence. Imaging at 7 T could depict the extent of stenosis, and revealed the disruption and ulcer of the plaque.

Conclusions: 
This study demonstrates that 2 four-channel transmit/receive RF arrays for each side of the neck is a suitable concept for in vivo MRI of the carotid arteries at 7 Tesla. Further studies are needed to explore and exploit the full potential of 7 T high-field MRI for carotid atherosclerotic plaque imaging.
Y1  - 2011
U6  - http://dx.doi.org/10.1097/RLI.0b013e318206cee4
SN  - 1536-0210
VL  - 46
IS  - 4
SP  - 246
EP  - 254
PB  - Wolters Kluwer
CY  - Köln
ER  - 
TY  - JOUR
A1  - Sieker, Tim
A1  - Neuner, Andreas
A1  - Dimitrova, Darina
A1  - Tippkötter, Nils
A1  - Muffler, Kai
A1  - Bart, Hans-Jörg
A1  - Heinzle, Elmar
A1  - Ulber, Roland
T1  - Ethanol production from grass silage by simultaneous pretreatment, saccharification and fermentation: First steps in the process development
JF  - Engineering in Life Sciences
N2  - Grass silage provides a great potential as renewable feedstock. Two fractions of the grass silage, a press juice and the fiber fraction, were evaluated for their possible use for bioethanol production. Direct production of ethanol from press juice is not possible due to high concentrations of organic acids. For the fiber fraction, alkaline peroxide or enzymatic pretreatment was used, which removes the phenolic acids in the cell wall. In this study, we demonstrate the possibility to integrate the enzymatic pretreatment with a simultaneous saccharification and fermentation to achieve ethanol production from grass silage in a one-process step. Achieved yields were about 53 g ethanol per kg silage with the alkaline peroxide pretreatment and 91 g/kg with the enzymatic pretreatment at concentrations of 8.5 and 14.6 g/L, respectively. Furthermore, it was shown that additional supplementation of the fermentation medium with vitamins, trace elements and nutrient salts is not necessary when the press juice is directly used in the fermentation step.
Y1  - 2011
U6  - http://dx.doi.org/10.1002/elsc.201000160
N1  - Special Issue "Bioprocess‐oriented plant design"
VL  - 11
IS  - 4
SP  - 436
EP  - 442
PB  - Wiley
CY  - Weinheim
ER  -