TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, Ko-ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Eurosensor XXIV Conference SP - 520 EP - 523 ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Friedrich, Peter A1 - Rysstad, G. A1 - Berger, J. A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Realization of a calorimetric gas sensor on polyimide foil for applications in aseptic food industry JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Eurosensor XXIV Conference SP - 264 EP - 267 ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Kaneko, Kazumi A1 - Matsuo, Akira A1 - Wagner, Torsten A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Miniaturized chemical imaging sensor system using an OLED display panel JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Eurosensor XXIV Conference SP - 516 EP - 519 ER - TY - JOUR A1 - Bohrn, U. A1 - Stütz, E. A1 - Fleischer, M. A1 - Schöning, Michael Josef T1 - Real-time detection of CO by eukaryotic cells JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Eurosensor XXIV Conference SP - 17 EP - 20 ER - TY - JOUR A1 - Werner, Frederik A1 - Schusser, Sebastian A1 - Spalthahn, Heiko A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Field-programmable gate array based controller for multi spot light-addressable potentiometric sensors with integrated signal correction mode JF - Electrochimica Acta N2 - A light-addressable potentiometric sensor (LAPS) can measure the concentration of one or several analytes at the sensor surface simultaneously in a spatially resolved manner. A modulated light pointer stimulates the semiconductor structure at the area of interest and a responding photocurrent can be read out. By simultaneous stimulation of several areas with light pointers of different modulation frequencies, the read out can be performed at the same time. With the new proposed controller electronic based on a field-programmable gate array (FPGA), it is possible to control the modulation frequencies, phase shifts, and light brightness of multiple light pointers independently and simultaneously. Thus, it is possible to investigate the frequency response of the sensor, and to examine the analyte concentration by the determination of the surface potential with the help of current/voltage curves and phase/voltage curves. Additionally, the ability to individually change the light intensities of each light pointer is used to perform signal correction. Y1 - 2011 U6 - http://dx.doi.org/10.1016/j.electacta.2011.03.012 SN - 0013-4686 VL - 56 IS - 26 SP - 9656 EP - 9660 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Pedraza, A. M. A1 - Gandhi, D. A1 - Ingebrandt, S. A1 - Moritz, W. A1 - Schöning, Michael Josef T1 - An array of field-effect nanoplate SOI capacitors for (bio-)chemical sensing JF - Biosensors and Bioelectronics. 26 (2011), H. 6 Y1 - 2011 SN - 0956-5663 SP - 3023 EP - 3028 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kirchner, Patrick A1 - Li, Bin A1 - Spelthahn, Heiko A1 - Henkel, Hartmut A1 - Schneider, Andreas A1 - Friedrich, Peter A1 - Kolstad, Jens A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Thin-film calorimetric H2O2 gas sensor for the validation of germicidal effectivity in aseptic filling processes JF - Sensors and Actuators B: Chemical. 154 (2011), H. 2 Y1 - 2011 SN - 1873-3077 N1 - EUROSENSORS XXIII SP - 257 EP - 263 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef T1 - Phase-mode LAPS and its application to chemical imaging JF - Sensors and Actuators B: Chemical. 154 (2011), H. 1 Y1 - 2011 SN - 1873-3077 SP - 28 EP - 32 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Yoshida, Midori A1 - Sakai, Taito A1 - Matsuzaka, Atsushi A1 - Wagner, Torsten A1 - Kanoh, Sanoh A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Differential setup of light-addressable potentiometric sensor with an enzyme reactor in a flow channel JF - Japanese Journal of Applied Physics. 50 (2011) Y1 - 2011 SN - 0021-4922 SP - 04DL08-1 EP - 04DL08-5 PB - Japan Society of Applied Physics CY - Bristol ER - TY - JOUR A1 - Gasparyan, F.V. A1 - Vitusevich, S.A. A1 - Offenhäusser, A. A1 - Schöning, Michael Josef T1 - Modified charge fluctuation noise model for electrolyte-insulator-semiconductor devices JF - Modern Physics Letters B (MPLB). 25 (2011), H. 11 Y1 - 2011 SN - 0217-9849 SP - 831 EP - 840 PB - World Scientific Publ. CY - Singapur ER - TY - JOUR A1 - Grinsven, B. van A1 - Bon, N. vanden A1 - Grieten, L. A1 - Murib, M. A1 - Janssen, S. D. A1 - Haenen, K. A1 - Schneider, E. A1 - Ingebrandt, E. A1 - Schöning, Michael Josef A1 - Vermeeren, V. A1 - Ameloot, M. A1 - Michiels, L. A1 - Thoelen, R. A1 - Ceuninck, W. de A1 - Wagner, P. T1 - Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation JF - Lab on a Chip Y1 - 2011 SN - 1473-0197 VL - 11 IS - 9 SP - 1656 EP - 1663 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Gun, Jenny A1 - Gutkin, Vitaly A1 - Lev, Ovadia A1 - Boyen, Hans-Gerd A1 - Saitner, Marc A1 - Wagner, Patrick A1 - Olieslaeger, Marc D´ A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices JF - Journal of Physical Chemistry C. 115 (2011), H. 11 Y1 - 2011 SN - 1932-7455 SP - 4439 EP - 4445 PB - American Cemical Society CY - Washington, DC ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef T1 - Phase-mode operation of FDM-LAPS JF - Sensor letters Y1 - 2011 SN - 1546-1971 VL - 9 IS - 2 SP - 691 EP - 694 PB - American Scientific Publishers CY - Stevenson Ranch, Calif. ER - TY - JOUR A1 - Bohrn, Ulrich A1 - Stütz, Evamaria A1 - Fleischer, Maximilian A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Eukaryotic cell lines as a sensitive layer for direct monitoring of carbon monoxide JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1345 EP - 1350 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Bäcker, Matthias A1 - Pouyeshman, S. A1 - Schnitzler, Thomas A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Biselli, Manfred A1 - Schöning, Michael Josef T1 - A silicon-based multi-sensor chip for monitoring of fermentation processes JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1364 EP - 1369 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Werner, Frederik A1 - Krumbe, Christoph A1 - Schumacher, Katharina A1 - Groebel, Simone A1 - Spelthahn, Heiko A1 - Stellberg, Michael A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Selmer, Thorsten A1 - Keusgen, Michael A1 - Baumann, Marcus A1 - Schöning, Michael Josef T1 - Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1340 EP - 1344 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Friedrich, Peter A1 - Berger, Jörg A1 - Suso, Henri-Pierre A1 - Kupyna, Andriy A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Optimisation and fabrication of a calorimetric gas sensor built up on a polyimide substrate for H2O2 monitoring JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1235 EP - 1240 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Werner, Moritz A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Capacitance–voltage and impedance-spectroscopy characteristics of nanoplate EISOI capacitors JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1327 EP - 1332 PB - Wiley-VCH CY - Berlin ER - TY - JOUR A1 - Reisert, Steffen A1 - Geissler, Hanno A1 - Flörke, Rudolf A1 - Näther, Niko A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Towards a multi-sensor system for the evaluation of aseptic processes employing hydrogen peroxide vapour (H2O2) JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1351 EP - 1356 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Poghossian, Arshak A1 - Wagner, Holger A1 - Schöning, Michael Josef T1 - Functional testing and characterisation of (bio-)chemical sensors on wafer level JF - Sensors and Actuators B: Chemical. 154 (2011), H. 2 Y1 - 2011 SN - 1873-3077 N1 - EUROSENSORS XXIII SP - 169 EP - 173 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wagner, Torsten A1 - Werner, Frederik A1 - Miyamoto, Ko-Ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - A high-density multi-point LAPS set-up using a VCSEL array and FPGA control JF - Sensors and Actuators B: Chemical. 154 (2011), H. 2 Y1 - 2011 SN - 1873-3077 N1 - EUROSENSORS XXIII SP - 124 EP - 128 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Mimura, Shuhei A1 - Kanoh, Shiníchiro A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Constant-phase-mode operation of the light-addressable potentiometric sensor JF - Sensors and Actuators B: Chemical. 154 (2011), H. 2 Y1 - 2011 SN - 1873-3077 N1 - EUROSENSORS XXIII SP - 119 EP - 123 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Werner, Frederik A1 - Groebel, Simone A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Selmer, Thorsten A1 - Baumann, Marcus A1 - Schöning, Michael Josef T1 - Überwachung der metabolischen Aktivität von Mikroorganismen zur Kontrolle des biologischen Prozesses im Biogasfermenter JF - Biogas 2011 : Energieträger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt Y1 - 2011 SN - 978-3-18-092121-1 N1 - Gesellschaft Energie und Umwelt ; Fachtagung Biogas ; (6 : ; 2011.06.08-09 : ; Braunschweig) ; VDI-Berichte ; 2121 SP - 285 EP - 286 PB - VDI-Verl. CY - Düsseldorf ER - TY - JOUR A1 - Reisert, Steffen A1 - Geissler, H. A1 - Florke, R. A1 - Wagner, P. A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Controlling aseptic sterilization processes by means of a multi-sensor system Y1 - 2011 N1 - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France SP - 18 EP - 22 PB - IEEE CY - New York ER - TY - JOUR A1 - Heiden, W. A1 - Turek, M. A1 - Schöning, Michael Josef T1 - TasteIT : Analyzing chemical sensor data using fuzzy logic Y1 - 2011 SN - 978-1-4244-9910-6 N1 - 2011 IEEE Workshop on Merging Fields of Computational Intelligence and Sensor Technology ; 11.-15. April 2011 Paris, France SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Heiden, W. A1 - Turek, M. A1 - Schöning, Michael Josef T1 - Analysis of chemical sensor data JF - Proceedings of the 4th Russian-German Workshop "Innovation Information Technologies: Theory and practice" : Ufa, Russia, April 8-13, 2011 / eds. Yupsova, Nafisa ... Y1 - 2011 SN - 978-5-4221-0159-7 SP - 76 EP - 81 PB - State Aviation Technical Univ. CY - Ufa ER - TY - JOUR A1 - Paczkowski, Sebastian A1 - Weißbecker, Bernhard A1 - Schöning, Michael Josef A1 - Schütz, Stefan T1 - Biosensors on the Basis of Insect Olfaction JF - Insect biotechnology / Andreas Vilcinskas, ed. Y1 - 2011 SN - 978-90-481-9640-1 N1 - Biologically-inspired system ; 2 SP - 225 EP - 240 PB - Springer CY - Dordrecht [u.a.] ER - TY - JOUR A1 - Malzahn, Kerstin A1 - Windmiller, Joshua Ray A1 - Valdés-Ramírez, Gabriela A1 - Wang, Joseph A1 - Schöning, Michael Josef T1 - Wearable electrochemical sensors for in situ analysis in marine environments JF - Analyst. 136 (2011), H. 14 Y1 - 2011 SN - 0003-2654 SP - 2912 EP - 2917 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Gasparyan, Ferdinand V. A1 - Poghossian, Arshak A1 - Vitusevich, Svetlana A. A1 - Petrychuk, Mykhaylo V. A1 - Sydoruk, Viktor A. A1 - Siqueira, José R. Jr. A1 - Oliveira, Osvaldo N. Jr. A1 - Offenhäusser, Andreas A1 - Schöning, Michael Josef T1 - Low-Frequency Noise in Field-Effect Devices Functionalized With Dendrimer/Carbon-Nanotube Multilayers JF - IEEE Sensors Journal. 11 (2011), H. 1 Y1 - 2011 SN - 1530-437X SP - 142 EP - 149 PB - IEEE CY - New York ER - TY - JOUR A1 - Bäcker, Matthias A1 - Delle, L. A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Zang, Werner A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Electrochemical sensor array for bioprocess monitoring JF - Electrochimica Acta (2011) Y1 - 2011 VL - 56 IS - 26 SP - 9673 EP - 9678 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, K. A1 - Werner, Frederik A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Flexible electrochemical imaging with “zoom-in” functionality by using a new type of light-addressable potentiometric sensor Y1 - 2011 N1 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011 SP - 2133 EP - 2135 PB - IEEE CY - New York ER - TY - JOUR A1 - Miyamoto, K. A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Multi-well structure for cell culture on the chemical imaging sensor Y1 - 2011 N1 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011 SP - 2130 EP - 2132 PB - IEEE CY - New York ER - TY - JOUR A1 - Huck, Christina A1 - Jolly, Christina A1 - Wagner, Patrick A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen JF - Procedia Engineering. 25 (2011) Y1 - 2011 SN - 1877-7058 N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece SP - 1161 EP - 1164 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, Ko-ichiro A1 - Shigihara, Noriko A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor JF - Procedia Engineering. 25 (2011) Y1 - 2011 SN - 1877-7058 N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece SP - 791 EP - 794 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bohrn, U. A1 - Stütz, E. A1 - Fuchs, K. A1 - Fleischer, M. A1 - Schöning, Michael Josef A1 - Wagner, P. T1 - Air Quality Monitoring using a Whole-Cell based Sensor System JF - Procedia Engineering. 25 (2011) Y1 - 2011 SN - 1877-7058 N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece SP - 1421 EP - 1424 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Miyamoto, Ko-ichiro A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up JF - Procedia Engineering. 25 (2011) Y1 - 2011 SN - 1877-7058 N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece SP - 346 EP - 349 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Poghossian, Arshak A1 - Malzahn, K. A1 - Abouzar, Maryam H. A1 - Mehndiratta, P. A1 - Katz, E. A1 - Schöning, Michael Josef T1 - Integration of biomolecular logic gates with field-effect transducers JF - Electrochimica Acta. 56 (2011), H. 26 Y1 - 2011 SN - 0013-4686 SP - 9661 EP - 9665 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Arida, Hassan A. A1 - Al-haddad, Ameera A1 - Schöning, Michael Josef T1 - New Solid-State Organic Membrane Based Lead-Selective Micro-Electrode JF - International Journal of Electrochemical Science. 6 (2011), H. 9 Y1 - 2011 SN - 1452-3981 SP - 3858 EP - 3867 ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, K. A1 - Werner, Frederik A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) Y1 - 2011 U6 - http://dx.doi.org/10.1166/sl.2011.1620 VL - 9 IS - 2 SP - 812 EP - 815 PB - American Scientific Publishers CY - Stevenson Ranch, Calif. ER - TY - JOUR A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Miyamoto, Ko-ichiro A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up JF - Sensors and Actuators B: Chemical N2 - Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display. Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2011.12.102 SN - 0925-4005 N1 - Part of special issue "Selected Papers presented at Eurosensors XXV" VL - 175 SP - 118 EP - 122 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wagner, Torsten A1 - Werner, Frederik A1 - Miyamoto, Ko-Ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging JF - Sensors and Actuators B: Chemical N2 - Chemical imaging systems allow the visualisation of the distribution of chemical species on the sensor surface. This work represents a new flexible approach to read out light-addressable potentiometric sensors (LAPS) with the help of a digital light processing (DLP) set-up. The DLP, known well for video projectors, consists of a mirror-array MEMS device, which allows fast and flexible generation of light patterns. With the help of these light patterns, the sensor surface of the LAPS device can be addressed. The DLP approach has several advantages compared to conventional LAPS set-ups, e.g., the spot size and the shape of the light pointer can be changed easily and no mechanical movement is necessary, which reduces the size of the set-up and increases the stability and speed of the measurement. In addition, the modulation frequency and intensity of the light beam are important parameters of the LAPS set-up. Within this work, the authors will discuss two different ways of light modulation by the DLP set-up, investigate the influence of different modulation frequencies and different light intensities as well as demonstrate the scanning capabilities of the new set-up by pH mapping on the sensor surface. Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2010.12.003 SN - 0925-4005 N1 - Part of special issue "Eurosensors XXIV, 2010" VL - 170 SP - 34 EP - 39 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grinsven, Bart van A1 - Bon, Natalie vanden A1 - Strauven, Hannelore A1 - Grieten, Lars A1 - Murib, Mohammed A1 - Jiménez Monroy, Kathia L. A1 - Janssens, Stoffel D. A1 - Haenen, Ken A1 - Schöning, Michael Josef A1 - Vermeeren, Veronique A1 - Ameloot, Marcel A1 - Michiels, Luc A1 - Thoelen, Ronald A1 - Ceuninck, Ward de A1 - Wagner, Patrick T1 - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA. JF - ACS Nano N2 - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA. Y1 - 2012 U6 - http://dx.doi.org/10.1021/nn300147e SN - 1936-086X VL - 6 IS - 3 SP - 2712 EP - 2721 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Abouzar, Maryam H. A1 - Poghossian, Arshak A1 - Cherstvy, Andrey G. A1 - Pedraza, Angela M. A1 - Ingebrandt, Sven A1 - Schöning, Michael Josef T1 - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling JF - Physica Status Solidi (a) N2 - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface. Y1 - 2012 U6 - http://dx.doi.org/10.1002/pssa.201100710 SN - 1862-6319 VL - 209 SP - 925 EP - 934 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Bäcker, Matthias A1 - Raue, Markus A1 - Schusser, Sebastian A1 - Jeitner, C. A1 - Breuer, L. A1 - Wagner, P. A1 - Poghossian, Arshak A1 - Förster, Arnold A1 - Mang, Thomas A1 - Schöning, Michael Josef T1 - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films JF - Physica Status Solidi (a) N2 - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off. Y1 - 2012 U6 - http://dx.doi.org/10.1002/pssa.201100763 SN - 1862-6319 VL - 209 IS - 5 SP - 839 EP - 845 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Spelthahn, Heiko A1 - Schubert, Jürgen A1 - Schöning, Michael Josef T1 - Dünnschichtsensoren für die Schwermetallanalytik JF - GIT : Labor-Fachzeitschrift N2 - Die Detektion von Schadstoffen repräsentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte Dünnschichtsensoren bieten eine kostengünstige Möglichkeit, „online“-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuführen. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgläsern zur Detektion von Schwermetallen in wässrigen Medien vorgestellt. Y1 - 2012 SN - 0016-3538 VL - 56 IS - 4 SP - 285 EP - 287 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Bohrn, U. A1 - Stütz, E. A1 - Fuchs, K. A1 - Fleischer, M. A1 - Schöning, Michael Josef A1 - Wagner, P. T1 - Monitoring of irritant gas using a whole-cell-based sensor system JF - Sensors and Actuators B: Chemical N2 - Cell-based sensors for the detection of gases have long been underrepresented, due to the cellular requirement of being cultured in a liquid environment. In this work we established a cell-based gas biosensor for the detection of toxic substances in air, by adapting a commercial sensor chip (Bionas®), previously used for the measurement of pollutants in liquids. Cells of the respiratory tract (A549, RPMI 2650, V79), which survive at a gas phase in a natural context, are used as biological receptors. The physiological cell parameters acidification, respiration and morphology are continuously monitored in parallel. Ammonia was used as a highly water-soluble model gas to test the feasibility of the sensor system. Infrared measurements confirmed the sufficiency of the medium draining method. This sensor system provides a basis for many sensor applications such as environmental monitoring, building technology and public security. Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2012.05.088 SN - 0925-4005 VL - 175 SP - 208 EP - 217 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Kirchner, Patrick A1 - Reisert, Steffen A1 - Pütz, Patrick A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Characterisation of polymeric materials as passivation layer for calorimetric H2O2 gas sensors JF - Physica Status Solidi (a) N2 - Calorimetric gas sensors for monitoring the H₂O₂ concentration at elevated temperatures in industrial sterilisation processes have been presented in previous works. These sensors are built up in form of a differential set-up of a catalytically active and passive temperature-sensitive structure. Although, various types of catalytically active dispersions have been studied, the passivation layer has to be established and therefore, chemically as well as physically characterised. In the present work, fluorinated ethylene propylene (FEP), perfluoralkoxy (PFA) and epoxy-based SU-8 photoresist as temperature-stable polymeric materials have been investigated for sensor passivation in terms of their chemical inertness against H₂O₂, their hygroscopic properties as well as their morphology. The polymeric materials were deposited via spin-coating on the temperature-sensitive structure, wherein spin-coated FEP and PFA show slight agglomerates. However, they possess a low absorption of humidity due to their hydrophobic surface, whereas the SU-8 layer has a closed surface but shows a slightly higher absorption of water. All of them were inert against gaseous H₂O₂ during the characterisation in H₂O₂ atmosphere that demonstrates their suitability as passivation layer for calorimetric H₂O₂ gas sensors. Y1 - 2012 U6 - http://dx.doi.org/10.1002/pssa.201100773 SN - 1862-6319 VL - 209 IS - 5 SP - 859 EP - 863 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Spelthahn, Heiko A1 - Kirsanov, Dmitry A1 - Legin, Andrey A1 - Osterrath, Thomas A1 - Schubert, Jürgen A1 - Zander, Willi A1 - Schöning, Michael Josef T1 - Development of a thin-film sensor array for analytical monitoring of heavy metals in aqueous solutions JF - Physica Status Solidi (a) N2 - In industrial processes there is a variety of heavy metals (e.g., copper, zinc, cadmium, and lead) in use for wires, coatings, paints, alloys, batteries, etc. Since the application of these transition metals for industry is inevitable, it is a vital task to develop proper analytical techniques for their monitoring at low activity levels, especially because most of these elements are acutely toxic for biological organisms. The determination of ions in solution by means of a simple and inexpensive sensor array is, therefore, a promising task. In this work, a sensor array with heavy metal-sensitive chalcogenide glass membranes for the simultaneous detection of the four ions Ag⁺, Cu2⁺, Cd2⁺, and Pb2⁺ in solution is realized. The results of the physical characterization by means of microscopy, profilometry, Rutherford backscattering spectroscopy (RBS), and scanning electron microscopy (SEM) as well as the electrochemical characterization by means of potentiometric measurements are presented. Additionally, the possibility to expand the sensor array by polymeric sensor membranes is discussed. Y1 - 2012 SN - 1862-6319 U6 - http://dx.doi.org/10.1002/pssa.201100733 VL - 209 IS - 5 SP - 885 EP - 891 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Kaneko, Kazumi A1 - Matsuo, Akira A1 - Wagner, Torsten A1 - Kanoh, Shiníchiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Miniaturized chemical imaging sensor system using an OLED display panel JF - Sensors and Actuators B: Chemical N2 - The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the two-dimensional distribution of specific ions or molecules in the solution. In this study, we developed a miniaturized chemical imaging sensor system with an OLED display panel as a light source that scans the sensor plate. In the proposed configuration, the display panel is placed directly below the sensor plate and illuminates the back surface. The measured area defined by illumination can be arbitrarily customized to fit the size and the shape of the sample to be measured. The waveform of the generated photocurrent, the current–voltage characteristics and the pH sensitivity were investigated and pH imaging with this miniaturized system was demonstrated. KW - LAPS KW - Light-addressable potentiometric sensor KW - Chemical imaging sensor KW - Organic light-emitting diode display Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2011.02.029 SN - 0925-4005 N1 - Part of special issue "Eurosensors XXIV, 2010" VL - 170 SP - 82 EP - 87 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schusser, Sebastian A1 - Poghossian, Arshak A1 - Bäcker, Matthias A1 - Leinhos, Marcel A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Characterization of biodegradable polymers with capacitive field-effect sensors JF - Sensors and actuators B: Chemical N2 - In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. KW - Impedance spectroscopy KW - C–V method KW - Real-time monitoring KW - Poly(d,l-lacticacid) KW - (Bio)degradation KW - Field-effect sensor Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2012.07.099 SN - 0925-4005 N1 - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" VL - 187 SP - 2 EP - 7 PB - Elsevier CY - Amsterdam ER -