TY  - JOUR
A1  - Dallas, Shannon
A1  - Salphati, Laurent
A1  - Gomez-Zepeda, David
A1  - Wanek, Thomas
A1  - Chen, Liangfu
A1  - Chu, Xiaoyan
A1  - Kunta, Jeevan
A1  - Mezler, Mario
A1  - Menet, Marie-Claude
A1  - Chasseigneaux, Stephanie
A1  - Declèves, Xavier
A1  - Langer, Oliver
A1  - Pierre, Esaie
A1  - DiLoreto, Karen
A1  - Hoft, Carolin
A1  - Laplanche, Loic
A1  - Pang, Jodie
A1  - Pereira, Tony
A1  - Andonian, Clara
A1  - Simic, Damir
A1  - Rode, Anja
A1  - Yabut, Jocelyn
A1  - Zhang, Xiaolin
A1  - Scheer, Nico
T1  - Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model
JF  - Molecular Pharmacology
N2  - Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp−/−) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP.
Y1  - 2016
U6  - https://doi.org/10.1124/mol.115.102079
SN  - 1521-0111
VL  - 89
IS  - 5
SP  - 492
EP  - 504
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Kleefeld, Andreas
A1  - Pieronek, J.
T1  - Elastic transmission eigenvalues and their computation via the method of fundamental solutions
JF  - Applicable Analysis
N2  - A stabilized version of the fundamental solution method to catch ill-conditioning effects is investigated with focus on the computation of complex-valued elastic interior transmission eigenvalues in two dimensions for homogeneous and isotropic media. Its algorithm can be implemented very shortly and adopts to many similar partial differential equation-based eigenproblems as long as the underlying fundamental solution function can be easily generated. We develop a corroborative approximation analysis which also implicates new basic results for transmission eigenfunctions and present some numerical examples which together prove successful feasibility of our eigenvalue recovery approach.
KW  - elastic scattering
KW  - method of fundamental solutions
KW  - Interior transmission eigenvalues
Y1  - 2020
U6  - https://doi.org/10.1080/00036811.2020.1721473
SN  - 1563-504X
VL  - 100
IS  - 16
SP  - 3445
EP  - 3462
PB  - Taylore & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Anik, Sabri
A1  - Frohberg, Martin G.
A1  - Kapoor, Madan Lal
T1  - Experiments and theoretical considerations on the solution of oxygen in binary metal alloys
JF  - Berichte der Bunsengesellschaft für physikalische Chemie
Y1  - 1983
SN  - 0005-9021
SN  - 0940-483X
VL  - 87
IS  - 12
SP  - 1201
EP  - 1204
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Harzheim, Thomas
A1  - Cronenbroeck, Tobias
T1  - First SIMO harmonic radar based on the SFCW concept and the HR transfer function
JF  - Remote sensing
N2  - This paper presents a new SIMO radar system based on a harmonic radar (HR) stepped frequency continuous wave (SFCW) architecture. Simple tags that can be electronically individually activated and deactivated via a DC control voltage were developed and combined to form an MO array field. This HR operates in the entire 2.45 GHz ISM band for transmitting the illumination signal and receives at twice the stimulus frequency and bandwidth centered around 4.9 GHz. This paper presents the development, the basic theory of a HR system for the characterization of objects placed into the propagation path in-between the radar and the reflectors (similar to a free-space measurement with a network analyzer) as well as first measurements performed by the system. Further detailed measurement series will be made available later on to other researchers to develop AI and machine learning based signal processing routines or synthetic aperture radar algorithms for imaging, object recognition, and feature extraction. For this purpose, the necessary information is published in this paper. It is explained in detail why this SIMO-HR can be an attractive solution augmenting or replacing existing systems for radar measurements in production technology for material under test measurements and as a simplified MIMO system. The novel HR transfer function, which is a basis for researchers and developers for material characterization or imaging algorithms, is introduced and metrologically verified in a well traceable coaxial setup.
KW  - MUT measurement; scanner
KW  - transponder
KW  - SFCW
KW  - harmonic radar
KW  - nonlinear radar
Y1  - 2021
U6  - https://doi.org/10.3390/rs13245088
SN  - 2072-4292
N1  - This article belongs to the Special Issue "Nonlinear Junction Detection and Harmonic Radar"
VL  - 13
IS  - 24
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
T1  - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement
JF  - Journal of the mechanical behavior of biomedical materials
Y1  - 2017
U6  - https://doi.org/10.1016/j.jmbbm.2017.06.012
SN  - 1751-6161
VL  - 74
SP  - 400
EP  - 410
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wegner, Lena
A1  - von Arx, Georg
A1  - Sass-Klaassen, Ute G. W.
A1  - Eilmann, Britta
T1  - ROXAS – an efficient and accurate tool to detect vessels in diffuse-porous species
JF  - IAWA Journal / International Association of Wood Anatomists
Y1  - 2013
U6  - https://doi.org/10.1163/22941932-00000034
SN  - 0928-1541 (Print)
SN  - 2294-1932 (Online)
VL  - 34
IS  - 4
SP  - 425
EP  - 432
PB  - Brill
CY  - Leiden
ER  - 
TY  - JOUR
A1  - Richter, Charlotte
A1  - Braunstein, Bjoern
A1  - Stäudle, Benjamin
A1  - Attias, Julia
A1  - Suess, Alexander
A1  - Weber, Tobias
A1  - Mileva, Katja N.
A1  - Rittweger, Joern
A1  - Green, David A.
A1  - Albracht, Kirsten
T1  - Gastrocnemius medialis contractile behavior is preserved during 30% body weight supported gait training
JF  - Frontiers in Sports and Active Living
N2  - Rehabilitative body weight supported gait training aims at restoring walking function as a key element in activities of daily living. Studies demonstrated reductions in muscle and joint forces, while kinematic gait patterns appear to be preserved with up to 30% weight support. However, the influence of body weight support on muscle architecture, with respect to fascicle and series elastic element behavior is unknown, despite this having potential clinical implications for gait retraining. Eight males (31.9 ± 4.7 years) walked at 75% of the speed at which they typically transition to running, with 0% and 30% body weight support on a lower-body positive pressure treadmill. Gastrocnemius medialis fascicle lengths and pennation angles were measured via ultrasonography. Additionally, joint kinematics were analyzed to determine gastrocnemius medialis muscle–tendon unit lengths, consisting of the muscle's contractile and series elastic elements. Series elastic element length was assessed using a muscle–tendon unit model. Depending on whether data were normally distributed, a paired t-test or Wilcoxon signed rank test was performed to determine if body weight supported walking had any effects on joint kinematics and fascicle–series elastic element behavior. Walking with 30% body weight support had no statistically significant effect on joint kinematics and peak series elastic element length. Furthermore, at the time when peak series elastic element length was achieved, and on average across the entire stance phase, muscle–tendon unit length, fascicle length, pennation angle, and fascicle velocity were unchanged with respect to body weight support. In accordance with unchanged gait kinematics, preservation of fascicle–series elastic element behavior was observed during walking with 30% body weight support, which suggests transferability of gait patterns to subsequent unsupported walking.
KW  - AlterG
KW  - rehabilitation
KW  - gait
KW  - walking
KW  - ultrasound imaging
KW  - series elastic element behavior
KW  - muscle fascicle behavior
KW  - unloading
Y1  - 2021
U6  - https://doi.org/10.3389/fspor.2020.614559
SN  - 2624-9367
VL  - 2021
IS  - 2
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Bernecker, Andreas
A1  - Klier, Julia
A1  - Stern, Sebastian
A1  - Thiel, Lea
T1  - Sustaining high performance beyond public-sector pilot projects.
Y1  - 2018
IS  - September 2018
ER  - 
TY  - JOUR
A1  - Eilmann, Britta
A1  - Sterck, Frank J.
A1  - Wegner, L.
A1  - de Vries, Sven M. G.
A1  - von Arx, G.
A1  - Mohren, Godefridus M. J.
A1  - den Ouden, Jan
A1  - Sass-Klaassen, Ute G. W.
T1  - Wood structural differences between northern and southern beech provenances growing at a moderate site
JF  - Tree Physiology
Y1  - 2014
U6  - https://doi.org/10.1093/treephys/tpu069
SN  - 1758-4469  (Online)
SN  - 0829-318X (Print)
VL  - 34
IS  - 8
SP  - 882
EP  - 893
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Staat, Manfred
T1  - Physical response of hyperelastic models for composite materials and soft tissues
JF  - Asia pacific journal on computational engineering
Y1  - 2015
U6  - https://doi.org/10.1186/s40540-015-0015-x
SN  - 2196-1166
VL  - 2
IS  - 3 (December 2015)
SP  - 1
EP  - 18
ER  - 
TY  - JOUR
A1  - Droop, Philipp
A1  - Chen, Shaohuang
A1  - Radford, Melissa J.
A1  - Paulßen, Elisabeth
A1  - Gates, Byron D.
A1  - Reilly, Raymond M.
A1  - Radchenko, Valery
A1  - Hoehr, Cornelia
T1  - Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy
JF  - Radiochimica Acta
N2  - Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).
KW  - 197m/gHg
KW  - Gold nanoparticle (AuNP)
KW  - Meitner-Auger-electron (MAE)
KW  - Targeted radionuclide therapy (TRT)
Y1  - 2023
U6  - https://doi.org/10.1515/ract-2023-0144
SN  - 2193-3405
VL  - 111
IS  - 10
SP  - 773
EP  - 779
PB  - De Gruyter
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Feichtinger, Linda M.
A1  - Eilmann, Britta
A1  - Buchmann, Nina
A1  - Rigling, Andreas
T1  - Trait-specific responses of Scots pine to irrigation on a short vs long time scale
JF  - Tree Physiology
Y1  - 2015
U6  - https://doi.org/10.1093/treephys/tpu114
SN  - 1758-4469  (Online)
SN  - 0829-318X (Print)
N1  - Ab 12 Monaten nach Veröffentlichung kostenfrei zugänglich.
VL  - 35
IS  - 00
SP  - 1
EP  - 12
PB  - Heron
CY  - Victoria, BC
ER  - 
TY  - JOUR
A1  - Valero, Daniel
A1  - Bung, Daniel Bernhard
A1  - Crookston, B.M.
T1  - Energy dissipation of a Type III basin under design and adverse conditions for stepped and smooth spillways
JF  - Journal of Hydraulic Engineering
N2  - New information regarding the influence of a stepped chute on the hydraulic performance of the United States Bureau of Reclamation (Reclamation) Type III hydraulic jump stilling basin is presented for design (steady) and adverse (decreasing tailwater) conditions. Using published experimental data and computational fluid dynamics (CFD) models, this paper presents a detailed comparison between smooth-chute and stepped-chute configurations for chute slopes of 0.8H:1V and 4H:1V and Froude numbers (F) ranging from 3.1 to 9.5 for a Type III basin designed for F = 8. For both stepped and smooth chutes, the relative role of each basin element was quantified, up to the most hydraulic extreme case of jump sweep-out. It was found that, relative to a smooth chute, the turbulence generated by a stepped chute causes a higher maximum velocity decay within the stilling basin, which represents an enhancement of the Type III basin’s performance but also a change in the relative role of the basin elements. Results provide insight into the ability of the CFD models [unsteady Reynolds-averaged Navier-Stokes (RANS) equations with renormalization group (RNG) k-ϵ turbulence model and volume-of-fluid (VOF) for free surface tracking] to predict the transient basin flow structure and velocity profiles. Type III basins can perform adequately with a stepped chute despite the effects steps have on the relative role of each basin element. It is concluded that the classic Type III basin design, based upon methodology by reclamation specific to smooth chutes, can be hydraulically improved for the case of stepped chutes for design and adverse flow conditions using the information presented herein.
Y1  - 2018
U6  - https://doi.org/10.1061/(ASCE)HY.1943-7900.0001482
SN  - 0733-9429
N1  - Article number 04018036
VL  - 144
IS  - 7
PB  - ASCE
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Teumer, T.
A1  - Capitain, C.
A1  - Ross-Jones, J.
A1  - Tippkötter, Nils
A1  - Rädle, M.
A1  - Methner, F.-J.
T1  - In-line Haze Monitoring Using a Spectrally Resolved Back Scattering Sensor
JF  - BrewingScience
N2  - In the present work an optical sensor in combination with a spectrally resolved detection device for in-line particle-size-monitoring for quality control in beer production is presented. The principle relies on the size and wavelength dependent backscatter of growing particles in fluids. Measured interference structures of backscattered light are compared with calculated theoretical values, based on Mie-Theory, and fitted with a linear least square method to obtain particle size distributions. For this purpose, a broadband light source in combination with a process-CCD-spectrometer (charge ? coupled device spectrometer) and process adapted fiber optics are used. The goal is the development of an easy and flexible measurement device for in-line-monitoring of particle size. The presented device can be directly installed in product fill tubes or vessels, follows CIP- (cleaning in place) and removes the need of sample taking. A proof of concept and preliminary results, measuring protein precipitation, are presented.
Y1  - 2018
SN  - 1613-2041
VL  - 71
IS  - 5/6
SP  - 49
EP  - 55
PB  - Fachverlag Hans Carl
CY  - Nürnberg
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Katz, Evgeny
A1  - Schöning, Michael Josef
T1  - Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips
JF  - Electroanalysis
N2  - The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.
Y1  - 2017
U6  - https://doi.org/10.1002/elan.201700208
SN  - 1521-4109
VL  - 29
IS  - 8
SP  - 1840
EP  - 1849
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Hillebrand, Jürgen
A1  - Sadeghfam, Arash
T1  - Novel Concept of a Digital SigmaDelta-PLL-Phase-Shift-Modulator / Hillebrand, Jürgen ; Sadeghfam, Arash ; Heuermann, Holger
Y1  - 2008
SN  - 978-3-8007-3086-5
N1  - Microwave Conference (GeMIC), 2008 German
SP  - 123
EP  - 126
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Sensors and Actuators B. 78 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 237
EP  - 242
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Steinbauer, Gerald
A1  - McPhillips, Graeme
A1  - Potgieter, Anet
T1  - Establishing the RoboCup Standard League in Africa - applying for the RoboCup Standard League with a German-Austrian-South African Research Project
Y1  - 2007
SP  - 1
EP  - 5
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Chemical and biological field-effect sensors for liquids – a status report
JF  - Handbook of biosensors and biochips / ed. Robert S. Marks ... Bd. 1
Y1  - 2007
SN  - 978-0-470-01905-4
SP  - 395
EP  - 412
PB  - Wiley
CY  - Chichester
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Schiek, Burkhard
T1  - LNN (Line-Network-Network): Verfahren zur Kalibrierung von Netzwerkanalysatoren
JF  - Kleinheubacher Berichte : Vorträge und Berichte der gemeinsamen Tagung des U.R.S.I.-Landesausschusses in der Bundesrepublik Deutschland / Hrsg.: Deutsche Telekom AG. 36. 1992 (1992)
Y1  - 1992
SP  - 327
EP  - 335
ER  - 
TY  - JOUR
A1  - Valero, Daniel
A1  - Bung, Daniel Bernhard
T1  - Vectrino profiler spatial filtering for shear flows based on the mean velocity gradient equation
JF  - Journal of Hydraulic Engineering
N2  - A new methodology is proposed to spatially filter acoustic Doppler velocimetry data from a Vectrino profiler based on the differential mean velocity equation. Lower and upper bounds are formulated in terms of physically based flow constraints. Practical implementation is discussed, and its application is tested against data gathered from an open-channel flow over a stepped macroroughness surface. The method has proven to detect outliers occurring all over the distance range sampled by the Vectrino profiler and has shown to remain applicable out of the region of validity of the velocity gradient equation. Finally, a statistical analysis suggests that physically obtained bounds are asymptotically representative.
Y1  - 2018
U6  - https://doi.org/10.1061/(ASCE)HY.1943-7900.0001485
SN  - 0733-9429
N1  - Article number 04018037
VL  - 144
IS  - 7
PB  - ASCE
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - FEM-computation of load carrying capacity of highly loaded passive components by direct methods. Heitzer, M. ; Staat, M.
JF  - Nuclear Engineering and Design. 193 (1999), H. 3
Y1  - 1999
SN  - 0029-5493
SP  - 349
EP  - 358
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Weil, M.
A1  - Cherstvy, A. G.
A1  - Schöning, Michael Josef
T1  - Electrical monitoring of polyelectrolyte multilayer formation by means of capacitive field-effect devices
JF  - Analytical and bioanalytical chemistry
N2  - The semiconductor field-effect platform represents a powerful tool for detecting the adsorption and binding of charged macromolecules with direct electrical readout. In this work, a capacitive electrolyte–insulator–semiconductor (EIS) field-effect sensor consisting of an Al-p-Si-SiO2 structure has been applied for real-time in situ electrical monitoring of the layer-by-layer formation of polyelectrolyte (PE) multilayers (PEM). The PEMs were deposited directly onto the SiO2 surface without any precursor layer or drying procedures. Anionic poly(sodium 4-styrene sulfonate) and cationic weak polyelectrolyte poly(allylamine hydrochloride) have been chosen as a model system. The effect of the ionic strength of the solution, polyelectrolyte concentration, number and polarity of the PE layers on the characteristics of the PEM-modified EIS sensors have been studied by means of capacitance–voltage and constant-capacitance methods. In addition, the thickness, surface morphology, roughness and wettabilityof the PE mono- and multilayers have been characterised by ellipsometry, atomic force microscopy and water contact-angle methods, respectively. To explain potential oscillations on the gate surface and signal behaviour of the capacitive field-effect EIS sensor modified with a PEM, a simplified electrostatic model that takes into account the reduced electrostatic screening of PE charges by mobile ions within the PEM has been proposed and discussed.
Y1  - 2013
U6  - https://doi.org/10.1007/s00216-013-6951-9
SN  - 1432-1130 ; 1618-2642
VL  - 405
IS  - 20
SP  - 6425
EP  - 6436
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Recent advances in biologically sensitive field-effect transistors (BioFETs)
JF  - Analyst. 127 (2002)
Y1  - 2002
SN  - 0003-2654
SP  - 1137
EP  - 1151
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Fritz, Christian
A1  - Lakemeyer, Gerhard
T1  - Using Golog for Deliberation and Team Coordination in Robotic Soccer / Ferrein, Alexander ; Fritz, Christian ; Lakemeyer, Gerhard
JF  - Künstliche Intelligenz : KI. 19 (2005), H. 1
Y1  - 2005
SN  - 0933-1875
SP  - 24
EP  - 30
ER  - 
TY  - JOUR
A1  - Sattler, Johannes Christoph
A1  - Röger, Marc
A1  - Schwarzbözl, Peter
A1  - Buck, Reiner
A1  - Macke, Ansgar
A1  - Raeder, Christian
A1  - Göttsche, Joachim
T1  - Review of heliostat calibration and tracking control methods
JF  - Solar Energy
N2  - Large scale central receiver systems typically deploy between thousands to more than a hundred thousand heliostats. During solar operation, each heliostat is aligned individually in such a way that the overall surface normal bisects the angle between the sun’s position and the aim point coordinate on the receiver. Due to various tracking error sources, achieving accurate alignment ≤1 mrad for all the heliostats with respect to the aim points on the receiver without a calibration system can be regarded as unrealistic. Therefore, a calibration system is necessary not only to improve the aiming accuracy for achieving desired flux distributions but also to reduce or eliminate spillage. An overview of current larger-scale central receiver systems (CRS), tracking error sources and the basic requirements of an ideal calibration system is presented. Leading up to the main topic, a description of general and specific terms on the topics heliostat calibration and tracking control clarifies the terminology used in this work. Various figures illustrate the signal flows along various typical components as well as the corresponding monitoring or measuring devices that indicate or measure along the signal (or effect) chain. The numerous calibration systems are described in detail and classified in groups. Two tables allow the juxtaposition of the calibration methods for a better comparison. In an assessment, the advantages and disadvantages of individual calibration methods are presented.
Y1  - 2020
U6  - https://doi.org/10.1016/j.solener.2020.06.030
VL  - 207
SP  - 110
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dachwald, Bernd
A1  - Wurm, Patrick
T1  - Mission analysis and performance comparison for an Advanced Solar Photon Thruster
JF  - Advances in Space Research
Y1  - 2011
SN  - 0273-1177
VL  - 48
IS  - 11
SP  - 1858
EP  - 1868
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Panc, Nicolae
A1  - Contiu, Glad
A1  - Bocanet, Vlad
A1  - Thurn, Laura
A1  - Sabau, Emilia
T1  - The influence of cutting technology on surface wear hardness
JF  - Academic Journal of Manufacturing Engineering
Y1  - 2019
SN  - 1583-7904
VL  - 17
IS  - 3
SP  - 205
EP  - 210
ER  - 
TY  - JOUR
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
T1  - ERIKA—Early Robotics Introduction at Kindergarten Age
JF  - Multimodal Technologies Interact
N2  - In this work, we report on our attempt to design and implement an early introduction to basic robotics principles for children at kindergarten age. One of the main challenges of this effort is to explain complex robotics contents in a way that pre-school children could follow the basic principles and ideas using examples from their world of experience. What sets apart our effort from other work is that part of the lecturing is actually done by a robot itself and that a quiz at the end of the lesson is done using robots as well. The humanoid robot Pepper from Softbank, which is a great platform for human–robot interaction experiments, was used to present a lecture on robotics by reading out the contents to the children making use of its speech synthesis capability. A quiz in a Runaround-game-show style after the lecture activated the children to recap the contents they acquired about how mobile robots work in principle. In this quiz, two LEGO Mindstorm EV3 robots were used to implement a strongly interactive scenario. Besides the thrill of being exposed to a mobile robot that would also react to the children, they were very excited and at the same time very concentrated. We got very positive feedback from the children as well as from their educators. To the best of our knowledge, this is one of only few attempts to use a robot like Pepper not as a tele-teaching tool, but as the teacher itself in order to engage pre-school children with complex robotics contents.
Y1  - 2018
U6  - https://doi.org/10.3390/mti2040064
SN  - 2414-4088
VL  - 2
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schwabedal, Justus T. C.
A1  - Sippel, Daniel
A1  - Brandt, Moritz D.
A1  - Bialonski, Stephan
T1  - Automated Classification of Sleep Stages and EEG Artifacts in Mice with Deep Learning
N2  - Sleep scoring is a necessary and time-consuming task in sleep studies. In animal models (such as mice) or in humans, automating this tedious process promises to facilitate long-term studies and to promote sleep biology as a data-driven f ield. We introduce a deep neural network model that is able to predict different states of consciousness (Wake, Non-REM, REM) in mice from EEG and EMG recordings with excellent scoring results for out-of-sample data. Predictions are made on epochs of 4 seconds length, and epochs are classified as artifactfree or not. The model architecture draws on recent advances in deep learning and in convolutional neural networks research. In contrast to previous approaches towards automated sleep scoring, our model does not rely on manually defined features of the data but learns predictive features automatically. We expect deep learning models like ours to become widely applied in different fields, automating many repetitive cognitive tasks that were previously difficult to tackle.
Y1  - 2018
U6  - https://doi.org/10.48550/arXiv.1809.08443
ER  - 
TY  - JOUR
A1  - Holtrup, S.
A1  - Sadeghfam, Arash
A1  - Heuermann, Holger
A1  - Awakowicz, P.
T1  - Characterization and optimization technique for microwave-driven high-intensity discharge lamps using hot S-parameters
JF  - IEEE transactions on microwave theories and techniques
N2  - High-intensity discharge lamps can be driven by radio-frequency signals in the ISM frequency band at 2.45 GHz, using a matching network to transform the impedance of the plasma to the source impedance. To achieve an optimal operating condition, a good characterization of the lamp in terms of radio frequency equivalent circuits under operating conditions is necessary, enabling the design of an efficient matching network. This paper presents the characterization technique for such lamps and presents the design of the required matching network. For the characterization, a high-intensity discharge lamp was driven by a monofrequent large signal at 2.45 GHz, whereas a frequency sweep over 300 MHz was performed across this signal to measure so-called small-signal hot S-parameters using a vector network analyzer. These parameters are then used as an equivalent load in a circuit simulator to design an appropriate matching network. Using the measured data as a black-box model in the simulation results in a quick and efficient method to simulate and design efficient matching networks in spite of the complex plasma behavior. Furthermore, photometric analysis of high-intensity discharge lamps are carried out, comparing microwave operation to conventional operation.
Y1  - 2014
U6  - https://doi.org/10.1109/TMTT.2014.2342652
SN  - 0018-9480
VL  - 62
IS  - 10
SP  - 2471
EP  - 2480
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Ritz, Thomas
T1  - Mass Customized Production of Information Services - The combination of economies-of-scale with economies-of-scope
JF  - Media firms : structures, operations, and performance ; [World Media Economics Conference, 5th : 2002 : Turku, Finland] / ed. by Robert G. Picard
Y1  - 2002
SN  - 0-8058-4165-2
N1  - World Media Economics Conference (5, 2002, Turku)
PB  - Erlbaum
CY  - Mahwah, NJ [u.a.]
ER  - 
TY  - JOUR
A1  - Rösch, C.
A1  - Kratz, F.
A1  - Hering, T.
A1  - Trautmann, S.
A1  - Umanskaya, N.
A1  - Tippkötter, Nils
A1  - Müller-Renno, C.M.
A1  - Ulber, Roland
A1  - Hannig, M.
A1  - Ziegler, C.
T1  - Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity
JF  - Colloids and Surfaces B: Biointerfaces
N2  - The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase.
Y1  - 2016
U6  - https://doi.org/10.1016/j.colsurfb.2016.09.048
VL  - 149
IS  - 1
SP  - 115
EP  - 121
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Bäcker, Matthias
A1  - Siegert, Petra
A1  - Willenberg, H.
A1  - Poghossian, Arshak
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline Based on Substrate Recycling Amplification
JF  - Procedia Engineering
N2  - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.
Y1  - 2015
U6  - https://doi.org/10.1016/j.proeng.2015.08.708
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 540
EP  - 543
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Niemüller, Tim
A1  - Ferrein, Alexander
A1  - Beck, Daniel
A1  - Lakemeyer, Gerhard
T1  - Design Principles of the Component-Based Robot Software Framework Fawkes
JF  - Simulation, Modeling, and Programming for Autonomous Robots
Y1  - 2010
N1  - Lecture Notes in Computer Science ; 6472 ; Second International Conference, SIMPAR 2010, Darmstadt, Germany, November 15-18, 2010. Proceedings
SP  - 300
EP  - 311
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Steinbauer, Gerald
T1  - On the Way to High-Level Programming for Resource-Limited Embedded Systems with Golog
JF  - Simulation, Modeling, and Programming for Autonomous Robots
Y1  - 2010
N1  - Lecture Notes in Computer Science ; 6472 ; Second International Conference, SIMPAR 2010, Darmstadt, Germany, November 15-18, 2010. Proceedings
SP  - 229
EP  - 240
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
T1  - Robot controllers for highly dynamic environments with real-time constraints
JF  - Künstliche Intelligenz : KI. 24 (2010), H. 2
Y1  - 2010
SN  - 1610-1987
SP  - 175
EP  - 178
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Self-Adjoint Operator
JF  - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.
Y1  - 2009
SN  - 978-3-540-70622-9
SP  - 692
EP  - 697
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Unitary Operator
JF  - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.
Y1  - 2009
SN  - 978-3-540-70622-9
SP  - 807
EP  - 809
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Projection
JF  - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.
Y1  - 2009
SN  - 978-3-540-70622-9
SP  - 497
EP  - 499
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Cherstvy, Andrey G.
A1  - Pedraza, Angela M.
A1  - Ingebrandt, Sven
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
JF  - Physica Status Solidi (a)
N2  - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100710
SN  - 1862-6319
VL  - 209
SP  - 925
EP  - 934
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Laack, Walter van
T1  - Therefore Fermat is right
JF  - American journal of humanities and social sciences : AJHSS
N2  - It was Fernat's idea to investigate how many numbers would fulfill the equation according to the Pythagorean Theorem if the exponent were increased to random, e.g. to a3 + b3 = c3. His question became therefore: are there two whole numbers the cubes of which add up to the volume of the cube of a third whole number? He posed this same question, of course, for all kinds of higher exponents, so that the equation could be generalized: is there an integral solution for the equation an + bn = cn, if the exponent n is higher than 2? Although in 1993, the English mathematician Andrew Wiles was able to produce an arithmetical proof for Fermat's famous theorem, I will show that there is a simple logical explanation which is also pragmatic and plausible and what is the result of a fundamental alternative idea how our world seems to be constructed.
Y1  - 2014
SN  - 2329-079X (E-Journal); 2329-0781 (Print)
VL  - 2
IS  - 2
SP  - 117
EP  - 120
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Aspects of the Quantum-Classical Connection Based on Statistical Maps
JF  - Foundations of Physics
Y1  - 2019
U6  - https://doi.org/10.1007/s10701-019-00269-9
VL  - 49
IS  - 6
SP  - 677
EP  - 692
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
T1  - Operator
JF  - Compendium of Quantum Physics : concepts, experiments, history and philosophy / Daniel Greenberger ... ed.
Y1  - 2009
SN  - 978-3-540-70622-9
SP  - 440
EP  - 444
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Ibrahim, Irfan
T1  - Novel theory and architecture of a vector signal generator implemented with two PLLs / Ibrahim, Irfan ; Heuermann, Holger
JF  - European Conference on Wireless Technology, 2008. EuWiT 2008.
Y1  - 2008
SN  - 978-2-87487-008-8
SP  - 85
EP  - 88
ER  - 
TY  - JOUR
A1  - Stulpe, Werner
A1  - Busch, P.
A1  - Hellwig, K.-E.
T1  - Classical Representations of Finite-Dimensional Quantum Mechanics. Busch, P.; Hellwig, K.-E.; Stulpe, W.
JF  - International Journal of Theoretical Physics. 32 (1993), H. 3
Y1  - 1993
SN  - 1572-9575
SP  - 399
EP  - 405
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
T1  - Dual mode radio: A new tranceiver architecture for UWB and 60 GHz-applications
JF  - European Conference on Wireless Technology, 2008. EuWiT 2008.
Y1  - 2008
SN  - 978-2-87487-008-8
SP  - 147
EP  - 150
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Krämer, Melina
A1  - Abouzar, Maryam H.
A1  - Pita, Marcos
A1  - Katz, Evgeny
A1  - Schöning, Michael Josef
T1  - Interfacing of biocomputing systems with silicon chips: Enzyme logic gates based on field-effect devices
JF  - Procedia Chemistry. 1 (2009), H. 1
Y1  - 2009
SN  - 1876-6196
N1  - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23
SP  - 682
EP  - 685
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Geissler, Hanno
A1  - Schöning, Michael Josef
T1  - Rapid methods and sensors for milk quality monitoring and spoilage detection
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.04.040
SN  - 0956-5663
VL  - 140
IS  - Article 111272
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Laack, Walter van
T1  - Nature is much smarter than expected: the Genetic Code is not degenerate
JF  - American journal of humanities and social sciences
N2  - In any books about genetics it can still today be read that our genetic code is called “degenerate” because it is still believed that 43 = 64 triplets encode the 20 essential amino acids. Indeed we have to assume the inverse law, what means that 34 = 81 exact code positions are really effective for our genetic code and encode the amino acids, compiled to proteins. This very important discovery leads to two completely new results that are limits-overlooking: 1) 34 (=81) genetic code positions mean exactly the same number as there are stable and naturally existing chemical elements in our universe. This famous argument should now lead to some alternative, as well as new fundamental conclusions about our existence. 2) A genetic code positioning system shows that nature is much smarter than expected: mutations are made less dangerous than believed, because they won't be that easily able any more to cause severe damages in the protein-synthesis. This should also lead to some alternative views upon evolution of life.
Y1  - 2014
SN  - 2329-0781 (Print) ; 2329-079X (Online)
VL  - Vol. 2
IS  - No. 1
SP  - 10
EP  - 12
ER  -