TY  - JOUR
A1  - Droop, Philipp
A1  - Chen, Shaohuang
A1  - Radford, Melissa J.
A1  - Paulßen, Elisabeth
A1  - Gates, Byron D.
A1  - Reilly, Raymond M.
A1  - Radchenko, Valery
A1  - Hoehr, Cornelia
T1  - Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy
JF  - Radiochimica Acta
N2  - Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).
KW  - 197m/gHg
KW  - Gold nanoparticle (AuNP)
KW  - Meitner-Auger-electron (MAE)
KW  - Targeted radionuclide therapy (TRT)
Y1  - 2023
U6  - https://doi.org/10.1515/ract-2023-0144
SN  - 2193-3405
VL  - 111
IS  - 10
SP  - 773
EP  - 779
PB  - De Gruyter
CY  - Berlin [u.a.]
ER  - 
TY  - JOUR
A1  - Saretzki, Charlotte
A1  - Bergmann, Ole
A1  - Dahmann, Peter
A1  - Janser, Frank
A1  - Keimer, Jona
A1  - Machado, Patricia
A1  - Morrison, Audry
A1  - Page, Henry
A1  - Pluta, Emil
A1  - Stübing, Felix
A1  - Küpper, Thomas
T1  - Are small airplanes safe with regards to COVID-19 transmission?
JF  - Journal of Travel Medicine
Y1  - 2021
U6  - https://doi.org/10.1093/jtm/taab105
SN  - 1708-8305
VL  - 28
IS  - 7
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Ulmer, Jessica
A1  - Braun, Sebastian
A1  - Cheng, Chi-Tsun
A1  - Dowey, Steve
A1  - Wollert, Jörg
T1  - A human factors-aware assistance system in manufacturing based on gamification and hardware modularisation
JF  - International Journal of Production Research
N2  - Assistance systems have been widely adopted in the manufacturing sector to facilitate various processes and tasks in production environments. However, existing systems are mostly equipped with rigid functional logic and do not provide individual user experiences or adapt to their capabilities. This work integrates human factors in assistance systems by adjusting the hardware and instruction presented to the workers’ cognitive and physical demands. A modular system architecture is designed accordingly, which allows a flexible component exchange according to the user and the work task. Gamification, the use of game elements in non-gaming contexts, has been further adopted in this work to provide level-based instructions and personalised feedback. The developed framework is validated by applying it to a manual workstation for industrial assembly routines.
KW  - Human factors
KW  - assistance system
KW  - gamification
KW  - adaptive systems
KW  - manufacturing
Y1  - 2023
U6  - https://doi.org/10.1080/00207543.2023.2166140
SN  - 0020-7543 (Print)
SN  - 1366-588X (Online)
PB  - Taylor & Francis
ER  -