TY - CHAP A1 - Richter, Charlotte A1 - Braunstein, Bjoern A1 - Stäudle, Benjamin A1 - Attias, Julia A1 - Suess, Alexander A1 - Weber, T. A1 - Rittweger, Joern A1 - Green, David A. A1 - Albracht, Kirsten T1 - In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices T2 - 23rd Annual Congress of the European College of Sport Science, Dublin, Irland Y1 - 2018 ER - TY - JOUR A1 - Bernecker, Andreas A1 - Klier, Julia A1 - Stern, Sebastian A1 - Thiel, Lea T1 - Sustaining high performance beyond public-sector pilot projects. Y1 - 2018 IS - September 2018 ER - TY - RPRT A1 - Bernecker, Andreas A1 - Boyer, Pierre A1 - Gathmann, Christina T1 - The Role of Electoral Incentives for Policy Innovation: Evidence from the US Welfare Reform T2 - CESifo Working Paper Y1 - 2018 SN - ISSN 2364‐1428 (electronic version) IS - No. 6964 ER - TY - JOUR A1 - Tekin, Nurettin A1 - Ashikaga, Mitsugu A1 - Horikawa, Atsushi A1 - Funke, Harald T1 - Enhancement of fuel flexibility of industrial gas turbines by development of innovative hydrogen combustion systems JF - Gas for energy N2 - For fuel flexibility enhancement hydrogen represents a possible alternative gas turbine fuel within future low emission power generation, in case of hydrogen production by the use of renewable energy sources such as wind energy or biomass. Kawasaki Heavy Industries, Ltd. (KHI) has research and development projects for future hydrogen society; production of hydrogen gas, refinement and liquefaction for transportation and storage, and utilization with gas turbine / gas engine for the generation of electricity. In the development of hydrogen gas turbines, a key technology is the stable and low NOx hydrogen combustion, especially Dry Low Emission (DLE) or Dry Low NOx (DLN) hydrogen combustion. Due to the large difference in the physical properties of hydrogen compared to other fuels such as natural gas, well established gas turbine combustion systems cannot be directly applied for DLE hydrogen combustion. Thus, the development of DLE hydrogen combustion technologies is an essential and challenging task for the future of hydrogen fueled gas turbines. The DLE Micro-Mix combustion principle for hydrogen fuel has been in development for many years to significantly reduce NOx emissions. This combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized “diffusion-type” flames. The major advantages of this combustion principle are the inherent safety against flashback and the low NOx-emissions due to a very short residence time of the reactants in the flame region of the micro-flames. Y1 - 2018 IS - 2 PB - Vulkan-Verlag CY - Essen ER - TY - JOUR A1 - Balakirski, Galina A1 - Kotliar, Konstantin A1 - Pauly, Karolin J. A1 - Krings, Laura K. A1 - Rübben, Albert A1 - Baron, Jens M. A1 - Schmitt, Laurenz T1 - Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience JF - Dermatologic Surgery N2 - BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7% (19/284) of the cases. In 95% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13% to 29% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients. Y1 - 2018 U6 - http://dx.doi.org/10.1097/DSS.0000000000001615 IS - 44 (12) SP - 1525 EP - 1536 PB - Wolters Kluwer ER - TY - JOUR A1 - Kampker, Achim A1 - Schleser, Markus A1 - Triebs, Johannes A1 - Berg, Alexander-Karl A1 - Hansen, Jan Ole A1 - Fiedler, Falko T1 - Bauteilintegrierte Vorrichtungsfunktionen im Karosseriebau : Aktuelle Ergebnisse im Forschungsprojekt ProeK JF - ZWF Zeitschrift für wirtschaftlichen Fabrikbetrieb N2 - Das Forschungsprojekt Produktionseffizienz in der Kleinserie (ProeK) erarbeitet kostengünstige und effiziente Lösungsansätze für Prozessketten im Zukunftsfeld der Elektromobilität. Das Teilprojekt Karosserie setzt diese Zielsetzung durch innovative und praxisorientierte Produkt- und Prozesskonzepte mit neuartigen bauteilintegrierten Vorrichtungsfunktionen (BiV) um. Im Teilprojekt Außenhaut sollen Toleranzen adaptiv durch Anpassungen der Prozessparameter sowie Bauteilmanipulation kompensiert werden. Y1 - 2018 U6 - http://dx.doi.org/10.3139/104.112012 SN - 0947-0085 VL - 113 IS - 11 SP - 767 EP - 770 PB - De Gruyter CY - Berlin ER - TY - CHAP A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Case studies in initial sizing for hybrid-electric general aviation aircraft T2 - 2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio Y1 - 2018 U6 - http://dx.doi.org/10.2514/6.2018-5005 ER - TY - CHAP A1 - Rendon, Carlos A1 - Dieckmann, Simon A1 - Weidle, Mathias A1 - Dersch, Jürgen A1 - Teixeira Boura, Cristiano José A1 - Polklas, Thomas A1 - Kuschel, Marcus A1 - Herrmann, Ulf T1 - Retrofitting of existing parabolic trough collector power plants with molten salt tower systems T2 - AIP Conference Proceedings Y1 - 2018 U6 - http://dx.doi.org/10.1063/1.5067030 VL - 2033 IS - 1 SP - 030014-1 EP - 030014-8 ER - TY - JOUR A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs JF - CEAS Aeronautical Journal N2 - One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost–benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s13272-018-0352-x SN - 1869-5582 print SN - 1869-5590 online VL - 10 IS - 3 SP - 843 PB - Springer ER - TY - JOUR A1 - Berg, Alexander-Karl A1 - Schleser, Markus A1 - Delidovich, Artem A1 - Houben, Alexander T1 - Ultraschallunterstützter Schmelzklebstoffauftrag JF - adhäsion KLEBEN & DICHTEN Y1 - 2018 U6 - http://dx.doi.org/10.1007/s35145-018-0089-z VL - Volume 62 IS - Issue 12 SP - 32 EP - 37 PB - Springer ER - TY - CHAP A1 - Essingholt, Felix A1 - Meyer, Frederic A1 - Kuhn, Peter A1 - Schmidt, Philip A1 - Benkner, Thorsten A1 - Grabmaier, Anton T1 - Non-invasive heart beat measurement using microwave resonators T2 - Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018 Y1 - 2018 U6 - http://dx.doi.org/10.3390/proceedings2131002 SN - 2504-3900 SP - 1002 PB - MDPI CY - Basel ER - TY - JOUR A1 - Engel, Mareike A1 - Holtmann, Dirk A1 - Ulber, Roland A1 - Tippkötter, Nils T1 - Increased Biobutanol Production by Mediator‐Less Electro‐Fermentation JF - Biotechnology Journal N2 - A future bio-economy should not only be based on renewable raw materials but also in the raise of carbon yields of existing production routes. Microbial electrochemical technologies are gaining increased attention for this purpose. In this study, the electro-fermentative production of biobutanol with C. acetobutylicum without the use of exogenous mediators is investigated regarding the medium composition and the reactor design. It is shown that the use of an optimized synthetic culture medium allows higher product concentrations, increased biofilm formation, and higher conductivities compared to a synthetic medium supplemented with yeast extract. Moreover, the optimization of the reactor system results in a doubling of the maximum product concentrations for fermentation products. When a working electrode is polarized at −600 mV vs. Ag/AgCl, a shift from butyrate to acetone and butanol production is induced. This leads to an increased final solvent yield of Yᴀᴃᴇ = 0.202 gg⁻¹ (control 0.103 gg⁻¹), which is also reflected in a higher carbon efficiency of 37.6% compared to 23.3% (control) as well as a fourfold decrease in simplified E-factor to 0.43. The results are promising for further development of biobutanol production in bioelectrochemical systems in order to fulfil the principles of Green Chemistry. Y1 - 2018 U6 - http://dx.doi.org/10.1002/biot.201800514 SN - 1860-7314 IS - Volume 14, Issue 4 SP - Artikel 1800514 PB - Wiley-VCH ER - TY - CHAP A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - An Initial Sizing Methodology for Hybrid-Electric Light Aircraft T2 - AIAA AVIATION Forum 2018 Aviation Technology, Integration, and Operations Conference, Atlanta, Georgia, June 25 - 29, 2018 Y1 - 2018 U6 - http://dx.doi.org/10.2514/6.2018-4229 ER - TY - CHAP A1 - Schöning, Michael Josef A1 - Poghossian, Arshak T1 - Enzyme und Biosensorik T2 - Einführung in die Enzymtechnologie N2 - Enzymbasierte Biosensoren finden seit mehr als fünf Jahrzehnten einen prosperierenden Wachstumsmarkt und werden zunehmend auch in biotechnologischen Prozessen eingesetzt. In diesem Kapitel werden, ausgehend vom Sensorbegriff und typischen Kenngrößen für Biosensoren (Abschn. 18.1), elektrochemische Enzym-Biosensoren vorgestellt und deren typischen Einsatzgebiete diskutiert (Abschn. 18.2). Ein Blick über den „Tellerrand“ hinaus zeigt alternative Transduktorprinzipien (Abschn. 18.3) und führt abschließend in aktuelle Forschungstrends ein (Abschn. 18.4). Y1 - 2018 SN - 978-3-662-57619-9 U6 - http://dx.doi.org/10.1007/978-3-662-57619-9_18 SP - 323 EP - 347 PB - Springer Spektrum CY - Berlin ER - TY - JOUR A1 - Hirsch, Marko A1 - Kleeberg, Jochen A1 - Schmitz, Philipp T1 - Dynamische Asset-Allocation- Strategien im Niedrigzinsumfeld JF - Absolut|report : neue Perspektiven für institutionelle Investoren Y1 - 2018 IS - 6 SP - 52 PB - Absolut Research CY - Hamburg ER - TY - BOOK A1 - Focke, Markus A1 - Steinbeck, Jörn T1 - Steigerung der Anlagenproduktivität durch OEE-Management : Definitionen, Vorgehen und Methoden – von manuell bis Industrie 4.0 Y1 - 2018 SN - 978-3-658-21456-2 U6 - http://dx.doi.org/10.1007/978-3-658-21456-2 PB - Springer Fachmedien CY - Wiesbaden ER - TY - JOUR A1 - Hüning, Felix A1 - Heuermann, Holger A1 - Wache, Franz-Josef T1 - Wireless CAN without WLAN or Bluetooth JF - CAN Newsletter N2 - In two developed concepts, dual-mode radio enables CAN participants to be integrated wirelessly into a CAN network. Constructed from a few components, a protocol-free, real-time transmission and thus transparent integration into CAN is provided. Y1 - 2018 IS - December 2018 SP - 44 EP - 46 ER - TY - JOUR A1 - Wilson, C. E. A1 - Dickie, A. P. A1 - Schreiter, K. A1 - Wehr, R. A1 - Wilson, E. M. A1 - Bial, J. A1 - Scheer, Nico A1 - Wilson, I. D. A1 - Riley, R. J. T1 - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice JF - Archives of Toxicology N2 - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s00204-018-2212-1 SN - 1432-0738 VL - 92 IS - 6 SP - 1953 EP - 1967 PB - Springer ER - TY - CHAP A1 - Bindzus, Manuel A1 - Bragard, Michael T1 - Motivating Intuitive Understanding of the Switched Reluctance Machine in the Education of Undergraduate Students T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - http://dx.doi.org/10.1109/RTUCON.2018.8659870 SP - 1 EP - 6 ER - TY - CHAP A1 - Bragard, Michael A1 - Hoek, Hauke van A1 - Hoegen, Anne von A1 - Doncker, Rik W. De T1 - Motivation-based Learning: Teaching Fundamentals of Electrical Engineering with an LED Spinning Top T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - http://dx.doi.org/10.1109/RTUCON.2018.8659810 SP - 1 EP - 6 ER - TY - CHAP A1 - Rütters, René A1 - Weinheimer, Marius A1 - Bragard, Michael T1 - Teaching Control Theory with a Simplified Helicopter Model and a Classroom Fitting Hardware Test-Bench T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - http://dx.doi.org/10.1109/RTUCON.2018.8659871 ER - TY - CHAP A1 - Serror, Martin A1 - Henze, Martin A1 - Hack, Sacha A1 - Schuba, Marko A1 - Wehrle, Klaus T1 - Towards in-network security for smart homes T2 - 13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018 Y1 - 2018 SN - 978-145036448-5 U6 - http://dx.doi.org/10.1145/3230833.3232802 SP - Article numer 3232802 ER - TY - CHAP A1 - Röth, Thilo A1 - Deutskens, Christoph A1 - Kreisköther, Kai A1 - Heimes, Heiner Hans A1 - Schittny, Bastian A1 - Ivanescu, Sebastian A1 - Kleine Büning, Max A1 - Reinders, Christian A1 - Wessels, Saskia A1 - Haunreiter, Andreas A1 - Reisgen, Uwe A1 - Thiele, Regina A1 - Hameyer, Kay A1 - Doncker, Rik W. de A1 - Sauer, Uwe A1 - Hoek, Hauke van A1 - Hübner, Mareike A1 - Hennen, Martin A1 - Stolze, Thilo A1 - Vetter, Andreas A1 - Hagedorn, Jürgen A1 - Müller, Dirk A1 - Rewitz, Kai A1 - Wesseling, Mark A1 - Flieger, Björn T1 - Entwicklung von elektrofahrzeugspezifischen Systemen T2 - Elektromobilität N2 - Die Batterie ist eine der absolut zentralen Komponenten des Elektrofahrzeugs. Die serielle Entwicklung und Produktion dieser Batterien und die Verbesserung der Leistungen wird entscheidend für den Erfolg der Elektromobilität sein. Die Batterie ist jedoch nicht das einzige elektrofahrzeugspezifische System, das neu entwickelt, umkonzipiert oder verbessert werden muss. So sind ebenso die Entwicklung der neuen Fahrzeugstruktur sowie des elektrifizierten Antriebsstranges Teil dieses Kapitels. Weiterhin wird ein Blick auf das bedeutende Thema des Thermomanagements geworfen. Y1 - 2018 SN - 978-3-662-53137-2 U6 - http://dx.doi.org/10.1007/978-3-662-53137-2_6 SP - 279 EP - 386 PB - Springer Vieweg CY - Berlin, Heidelberg ER - TY - JOUR A1 - Laura, C.O. A1 - Drechsler, Klaus A1 - Erdt, M. A1 - Wesarg, S. A1 - Bale, R. T1 - Intervention assessment tool for primary tumors in the liver JF - Current Directions in Biomedical Engineering N2 - After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm. Y1 - 2018 U6 - http://dx.doi.org/10.1515/cdbme-2018-0081 SN - 2364-5504 VL - 4 IS - 1 SP - 337 EP - 340 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Heinke, Lars N. A1 - Knicker, Axel J. A1 - Albracht, Kirsten T1 - Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes JF - Isokinetics and Exercise Science N2 - BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results. Y1 - 2018 U6 - http://dx.doi.org/10.3233/IES-184111 SN - 1878-5913 VL - 26 IS - 4 SP - 265 EP - 274 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Lanzl, Ines T1 - Vaskuläre Biomarker der retinalen Gefäβanalyse T1 - Vascular Biomarkers in Retinal Vessel Analysis JF - Klinische Monatsblätter fur Augenheilkunde N2 - Mit modernen nicht invasiven bildgebenden Verfahren lassen sich anhand der Fundusfotografie bzw. der optischen Verfilmung Aspekte der funktionellen und strukturellen retinalen Gefäßveränderungen objektiv untersuchen. Der Zustand und das Verhalten retinaler Gefäße beeinflussen im prä-, post- und kapillaren Bereich den Blutfluss und strömungsbedingte Stoffwechselverhältnisse passiv und aktiv über den Gefäßdurchmesser. Retinale Gefäße gleichen von Aufbau und Funktion den zerebralen Gefäßen und spiegeln den Zustand der Mikrozirkulation wider. Mithilfe von aus den Gefäßweiten berechneten Biomarkern soll eine Aussage über die Prognose von systemischen vaskulär bedingten Erkrankungen getroffen werden. Die statische retinale Gefäßanalyse befasst sich mit der Untersuchung des Zustandes der prä- und postkapillaren Gefäßdurchmesser der retinalen Mikrozirkulation anhand einer optischen Fundusaufnahme. Bei der dynamischen retinalen Gefäßanalyse wird der Längsschnitt eines retinalen Gefäßes nicht invasiv funktionell und strukturell über einen Zeitraum vor, während und nach einer spezifischen vaskulären Stimulation untersucht. Die genaue Methodologie der Auswertung und die Bezeichnung der Parameter variieren bei unterschiedlichen Ansätzen. Mittels retinaler Gefäßanalyse wurden bislang mehrere klinische Querschnitts- und Interventionsstudien in der Augenheilkunde und anderen Fachgebieten, inkl. Kardiologie, Neurologie, Neurochirurgie, Nephrologie, Gynäkologie, Sportmedizin, Diabetologie, Hypertensiologie usw. durchgeführt. Mit der statischen retinalen Gefäßanalyse steht eine kostengünstige, reproduzierbare, nicht invasive Screeningtechnik zur Verfügung, um eine prognostische Aussage über die Gefäßgesundheit eines individuellen Patienten zu treffen. Die dynamische retinale Gefäßanalyse besitzt ein weiteres diagnostisches Anwendungsspektrum als die statische, da sie das Verhalten retinaler Gefäße zeitkontinuierlich untersucht. Die Evaluation vaskulärer Erkrankungen sowie zerebro- bzw. kardiovaskulärer Morbidität und Mortalität mittels mehrerer methodologischer Modalitäten retinaler Gefäßanalyse mit ihren jeweiligen quantitativen Biomarkern bietet eine zukunftsträchtige diagnostische Perspektive. Die interdisziplinäre klinische Anwendung dieser vaskulären Biomarker gewinnt zunehmend an Bedeutung, sowohl in der Augenheilkunde als auch in anderen Fachgebieten. Y1 - 2018 U6 - http://dx.doi.org/10.1055/a-0774-7987 SN - 0023-2165 VL - 235 IS - 12 SP - 1352 EP - 1359 PB - Thieme CY - Stuttgart ER - TY - CHAP A1 - Gao, H. A1 - Babilon, Katharina A1 - Pfaff, Raphael A1 - Gan, F. A1 - Reich, A. T1 - Model of wheel-rail contact for sanding and adhesion enhancement T2 - Proceedings of the 11th International Conference on Contact Mechanics and Wear of Rail/wheel Systems, CM 2018 Y1 - 2018 SN - 978-946186963-0 SP - 314 EP - 321 ER - TY - JOUR A1 - Franzen, Julius A1 - Pinders, Erik A1 - Pfaff, Raphael A1 - Enning, Manfred T1 - RailCrowd’s virtual fleets: Make most of your asset data JF - Deine Bahn N2 - For smaller railway operators or those with a diverse fleet, it can be difficult to collect sufficient data to improve maintenance programs. At the same time, new rules such as entity in charge of maintenance – ECM – regulations impose an additional workload by requiring a dedicated maintenance management system and specific reports. The RailCrowd platform sets out to facilitate compliance with ECM and similar regulations while at the same time pooling anonymised fleet data across operators to form virtual fleets, providing greater data insights. Y1 - 2018 SN - 0948-7263 IS - 9 SP - 11 EP - 13 PB - Bahn-Fachverlag CY - Berlin ER - TY - CHAP A1 - Pfaff, Raphael T1 - Railway Challenge 2018 - Ein Wettbewerb für Parkbahn-Lokomotiven T2 - Deine Bahn Y1 - 2018 SN - 0948-7263 SP - 22 EP - 24 ER - TY - CHAP A1 - Pfaff, Raphael A1 - Melcher, Karin A1 - Franzen, Julian T1 - Rare event simulation to optimise maintenance intervals of safety critical redundant subsystems T2 - Proceedings of the European Conference of the PHM Society Y1 - 2018 VL - 4 IS - 1 SP - 1 EP - 6 ER - TY - JOUR A1 - Schmidt, Bernd A1 - Enning, Manfred A1 - Pfaff, Raphael T1 - Güterwagen 4.0 – Der Güterwagen für das Internet der Dinge Teil 3: Einführungsszenarien für aktive, kommunikative Güterwagen JF - ETR - Eisenbahntechnische Rundschau N2 - Wenn durch innovative, automatisierte Güterwagen betriebswirtschaftliche Vorteile nutzbar gemacht werden sollen, muss die Migration auf das neue System in sinnvollen Teilschritten unter Berücksichtigung der organisationellen und betrieblichen Vereinbarkeit vorgenommen werden. Eine stufenweise Migration mit Nachrüstbarkeit und Kompatibilität kann die optimale Ausstattungsvariante für die unterschiedlichen Betriebsszenarien sowie eine Steigerung der Wirtschaftlichkeit des Gesamtsystems bieten. Y1 - 2018 SN - 0013-2845 VL - 67 IS - 5 SP - 60 EP - 64 PB - DVV Media Group CY - Hamburg ER - TY - JOUR A1 - Thomas, Axel T1 - Technologiezentren in der Aachener Region – Retrospektiven und Perspektiven JF - VM Verwaltung und Management Y1 - 2018 U6 - http://dx.doi.org/10.5771/0947-9856-2018-3-147 SN - 0947-9856 VL - 24 IS - 3 SP - 147 EP - 156 PB - Nomos CY - Baden-Baden ER - TY - JOUR A1 - Thomas, Axel T1 - Zielerreichungen der Technologie- und Gründerzentren aus Sicht der kommunalen Finanzwirtschaft – dargestellt am Beispiel der Aachener Region JF - Der Gemeindehaushalt Y1 - 2018 SN - 0340-3645 VL - 119 IS - 7 SP - 149 EP - 155 PB - Kohlhammer CY - Stuttgart ER - TY - CHAP A1 - Thurn, Laura A1 - Gebhardt, Andreas T1 - Strategy of Education on Materials for Students T2 - Conference Proceedings: „New Perspectives in Science Education" Y1 - 2018 SN - 978-88-6292-976-9 SP - 156 EP - 161 CY - Florence, Italy ER - TY - CHAP A1 - Klocke, Martina T1 - Schulter an Schulter – Zusammenarbeit in einem differenzierten Hochschulsystem T2 - Lehre und Lehrentwicklung an Fachhochschulen – Festschrift für Prof. Dr. med. W. Huhn Y1 - 2018 SN - 978-3-8309-3782-1 SP - 75 EP - 80 PB - Waxmann CY - Münster ER - TY - JOUR A1 - Klocke, Martina A1 - Richert, Vera A1 - Sube, Maike T1 - Vier Jahre „Guter Studienstart im Ingenieurbereich“: Entwicklung und Perspektiven des „Nullten Semesters“ in Aachen JF - Zeitschrift für Beratung und Studium N2 - Bereits 2015 wurde in der Zeitschrift „Qualität in der Wissenschaft“ (QiW) über das Kooperationsprojekt „Guter Studienstart im Ingenieurbereich“, das Orientierungssemester von RWTH und FH Aachen, berichtet. In diesem Artikel legen wir den Schwerpunkt auf die Entwicklung des Projekts in den Jahren 2015 bis 2018 und geben eine Rückschau sowie einen Ausblick auf die Entwicklungsperspektiven nach dem offiziellen Projektende. Y1 - 2018 SN - 1860-3068 VL - 13 IS - 1 SP - 17 EP - 22 PB - Universitätsverlag Webler CY - Bielefeld ER - TY - JOUR A1 - Babilon, Katharina A1 - Wilbring, Daniela A1 - Tappert, Tim A1 - Pfaff, Raphael A1 - Enning, Manfred T1 - Schienenfahrzeugtechnik hands on – FH Aachen IMechE Railway Challenge JF - Ingenieurspiegel Y1 - 2018 SN - 1868-5919 IS - 2 SP - 20 EP - 22 PB - Public Verlag CY - Bingen ER - TY - CHAP A1 - Bücking, Henrik A1 - Pfaff, Raphael A1 - Dirksmeier, Roger T1 - Sensor positioning and thermal model for condition monitoring of pressure gas reservoirs in vehicles T2 - Proceedings of the Fourth European Conference of the Prognostics and Health Management Society, Utrecht, Netherlands, 2018 Y1 - 2018 ER - TY - JOUR A1 - Ziebura, Dawid A1 - Bremen, Sebastian A1 - Schleifenbaum, Johannes Henrich A1 - Gebhardt, Andreas T1 - Machbarkeitsstudie zur Verarbeitung von nicht rostendem Stahl 1.4404 unter Verwendung einer Diodenlaser-basierten LPBF-Maschine mit kartesischem Achssystem JF - RTejournal - Forum für Rapid Technologie Y1 - 2018 SN - 1614-0923 VL - 15 ER - TY - JOUR A1 - Raupp, Sebastian M. A1 - Schmitt, Marcel A1 - Walz, Anna-Lena A1 - Diehm, Ralf A1 - Hummel, Helga A1 - Scharfer, Philip A1 - Schabel, Wilhelm T1 - Slot die stripe coating of low viscous fluids JF - Journal of Coatings Technology and Research N2 - Slot die coating is applied to deposit thin and homogenous films in roll-to-roll and sheet-to-sheet applications. The critical step in operation is to choose suitable process parameters within the process window. In this work, we investigate an upper limit for stripe coatings. This maximum film thickness is characterized by stripe merging which needs to be avoided in a stable process. It is shown that the upper limit reduces the process window for stripe coatings to a major extent. As a result, stripe coatings at large coating gaps and low viscosities are only possible for relatively thick films. Explaining the upper limit, a theory of balancing the side pressure in the gap region in the cross-web direction has been developed. Y1 - 2018 U6 - http://dx.doi.org/10.1007/s11998-017-0039-y SN - 1935-3804 VL - 15 IS - 5 SP - 899 EP - 911 PB - Springer ER - TY - BOOK A1 - Molinnus, Denise T1 - Integration of biomolecular logic principles with electronic transducers on a chip Y1 - 2018 PB - Philipps-Universität / Fachbereich Pharmazie CY - Marburg/Lahn ER - TY - CHAP A1 - Wiesen, Patrick A1 - Engemann, Heiko A1 - Limpert, Nicolas A1 - Kallweit, Stephan T1 - Learning by Doing - Mobile Robotics in the FH Aachen ROS Summer School T2 - European Robotics Forum 2018, TRROS18 Workshop Y1 - 2018 SP - 47 EP - 58 ER - TY - CHAP A1 - Birkl, Josef A1 - Diendorfer, Gerhard A1 - Kern, Alexander A1 - Thern, Stephan T1 - Extremely high lightning peak currents T2 - 34th International Conference on Ligntning Protection, 02-07 September 2018 Y1 - 2018 SN - 978-1-5386-6635-7 ER - TY - CHAP A1 - Röth, Thilo A1 - Pielen, Michael T1 - Personal Public Vehicle – ein urbanes Fahrzeugkonzept für die „Shared Mobility“ der Zukunft T2 - Karosseriebautage Hamburg 2018, 16. ATZ-Fachtagung N2 - Die urbane Mobilität ist im Wandel und insbesondere neue innovative Geschäftsmodelle werden einen wesentlichen Teil zur Lösung von künftigen Mobilitätsbedürfnissen beitragen. Die sogenannte „Shared Mobility“ gilt aktuell neben der Elektrifizierung des Antriebes und autonomem Fahrzeugtechnologien als einer der wichtigsten Trendthemen in der Automobilindustrie. Neue Mobilitätsdienstleistungen verlangen dabei verstärkt auch neue Fahrzeugkonzepte. Y1 - 2018 U6 - http://dx.doi.org/10.1007/978-3-658-22038-9_13 SP - 189 EP - 199 PB - Springer Vieweg CY - Wiesbaden ER - TY - JOUR A1 - Jochim, Haldor E. A1 - Menzel, Christoph J. T1 - Die Trassenbündelung als Planungsmethode nachhaltiger Verkehrspolitik JF - Der Eisenbahningenieur : EI Y1 - 2018 SN - 0013-2810 VL - 69 IS - 11 SP - 26 EP - 31 PB - DVV Media Group CY - Hamburg ER - TY - JOUR A1 - Puppe, Michael A1 - Giuliano, Stefano A1 - Frantz, Cathy A1 - Uhlig, Ralf A1 - Schumacher, Ralph A1 - Ibraheem, Wagdi A1 - Schmalz, Stefan A1 - Waldmann, Barbara A1 - Guder, Christoph A1 - Peter, Dennis A1 - Schwager, Christian A1 - Teixeira Boura, Cristiano José A1 - Alexopoulos, Spiros A1 - Spiegel, Michael A1 - Wortmann, Jürgen A1 - Hinrichs, Matthias A1 - Engelhard, Manfred A1 - Aust, Michael T1 - Techno-economic optimization of molten salt solar tower plants JF - AIP Conference Proceedings art.no. 040033 N2 - In this paper the results of a techno-economic analysis of improved and optimized molten salt solar tower plants (MSSTP plants) are presented. The potential improvements that were analyzed include different receiver designs, different designs of the HTF-system and plant control, increased molten salt temperatures (up to 640°C) and multi-tower systems. Detailed technological and economic models of the solar field, solar receiver and high temperature fluid system (HTF-system) were developed and used to find potential improvements compared to a reference plant based on Solar Two technology and up-to-date cost estimations. The annual yield model calculates the annual outputs and the LCOE of all variants. An improved external tubular receiver and improved HTF-system achieves a significant decrease of LCOE compared to the reference. This is caused by lower receiver cost as well as improvements of the HTF-system and plant operation strategy, significantly reducing the plant own consumption. A novel star receiver shows potential for further cost decrease. The cavity receiver concepts result in higher LCOE due to their high investment cost, despite achieving higher efficiencies. Increased molten salt temperatures seem possible with an adapted, closed loop HTF-system and achieve comparable results to the original improved system (with 565°C) under the given boundary conditions. In this analysis all multi tower systems show lower economic viability compared to single tower systems, caused by high additional cost for piping connections and higher cost of the receivers. REFERENCES Y1 - 2019 U6 - http://dx.doi.org/10.1063/1.5067069 VL - 2033 IS - Issue 1 PB - AIP Publishing CY - Melville, NY ER - TY - CHAP A1 - Gorzalka, Philip A1 - Dahlke, Dennis A1 - Göttsche, Joachim A1 - Israel, Martin A1 - Patel, Dhruvkumar A1 - Prahl, Christoph A1 - Schmiedt, Jacob Estevam A1 - Frommholz, Dirk A1 - Hoffschmidt, Bernhard A1 - Linkiewicz, Magdalena T1 - Building Tomograph–From Remote Sensing Data of Existing Buildings to Building Energy Simulation Input T2 - EBC, Annex 71, Fifth expert meeting, October 17-19, 2018, Innsbruck, Austria Y1 - 2018 ER - TY - CHAP A1 - Götten, Falk A1 - Havermann, Marc A1 - Braun, Carsten A1 - Gomez, Francisco A1 - Bil, Cees T1 - On the Applicability of Empirical Drag Estimation Methods for Unmanned Air Vehicle Design Read More: https://arc.aiaa.org/doi/10.2514/6.2018-3192 T2 - 2018 Aviation Technology, Integration, and Operations Conference, AIAA AVIATION Forum Y1 - 2018 U6 - http://dx.doi.org/10.2514/6.2018-3192 SN - 1533-385X N1 - AIAA 2018-3192 SP - Article 3192 ER - TY - JOUR A1 - Klubert, Joachim A1 - Malecha, Hartmut A1 - Sparla, Peter T1 - Modernisierung der geodätischen Messtechnik der Urfttalsperre JF - Wasserwirtschaft T2 - Modernisation of the geodetic measurement technology of the Urft dam Y1 - 2018 SN - 0043-0978 N1 - gedruckt in der Bereichsbibliothek Bayernallee vorhanden VL - 108 IS - 10 SP - 14 EP - 18 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Bauer, Waldemar A1 - Borchers, Kai A1 - Dumont, Etienne A1 - Grimm, Christian D. A1 - Ho, Tra-Mi A1 - Jahnke, Rico A1 - Lange, Caroline A1 - Maiwald, Volker A1 - Mikulz, Eugen A1 - Quantius, Dominik A1 - Reershemius, Siebo A1 - Renger, Thomas A1 - Riemann, Johannes A1 - Sasaki, Kaname A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Spröwitz, Tom A1 - Toth, Norbert A1 - Wejmo, Elisabet A1 - Biele, Jens A1 - Krause, Christian A1 - Cerotti, Matteo A1 - Peloni, Alessandro A1 - Dachwald, Bernd T1 - Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing T2 - 2018 IEEE Aerospace Conference : 3-10 March 2018 Y1 - 2018 SN - 978-1-5386-2014-4 ER -