TY - JOUR A1 - Ziebura, Dawid A1 - Bremen, Sebastian A1 - Schleifenbaum, Johannes Henrich A1 - Gebhardt, Andreas T1 - Machbarkeitsstudie zur Verarbeitung von nicht rostendem Stahl 1.4404 unter Verwendung einer Diodenlaser-basierten LPBF-Maschine mit kartesischem Achssystem JF - RTejournal - Forum für Rapid Technologie Y1 - 2018 SN - 1614-0923 VL - 15 ER - TY - JOUR A1 - Müller, Janina A1 - Beckers, Mario A1 - Mußmann, Nina A1 - Bongaerts, Johannes A1 - Büchs, Jochen T1 - Elucidation of auxotrophic deficiencies of Bacillus pumilus DSM 18097 to develop a defined minimal medium JF - Microbial Cell Factories N2 - Background Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is prone to significant variations from batch to batch and quality control is difficult. Therefore, the use of chemically defined media receives more and more attention in commercial fermentations. This concept results in better reproducibility, it simplifies downstream processing of secreted products and enable rapid scale-up. Culturing bacteria with unknown auxotrophies in chemically defined media is challenging and often not possible without an extensive trial-and-error approach. In this study, a respiration activity monitoring system for shake flasks and its recent version for microtiter plates were used to clarify unknown auxotrophic deficiencies in the model organism Bacillus pumilus DSM 18097. Results Bacillus pumilus DSM 18097 was unable to grow in a mineral medium without the addition of complex compounds. Therefore, a rich chemically defined minimal medium was tested containing basically all vitamins, amino acids and nucleobases, which are essential ingredients of complex components. The strain was successfully cultivated in this medium. By monitoring of the respiration activity, nutrients were supplemented to and omitted from the rich chemically defined medium in a rational way, thus enabling a systematic and fast determination of the auxotrophic deficiencies. Experiments have shown that the investigated strain requires amino acids, especially cysteine or histidine and the vitamin biotin for growth. Conclusions The introduced method allows an efficient and rapid identification of unknown auxotrophic deficiencies and can be used to develop a simple chemically defined tailor-made medium. B. pumilus DSM 18097 was chosen as a model organism to demonstrate the method. However, the method is generally suitable for a wide range of microorganisms. By combining a systematic combinatorial approach based on monitoring the respiration activity with cultivation in microtiter plates, high throughput experiments with high information content can be conducted. This approach facilitates media development, strain characterization and cultivation of fastidious microorganisms in chemically defined minimal media while simultaneously reducing the experimental effort. Y1 - 2018 U6 - https://doi.org/10.1186/s12934-018-0956-1 SN - 1475-2859 VL - 17 IS - 1 SP - Article No. 106 PB - BioMed Central ER - TY - RPRT A1 - Fischedick, Manfred A1 - Schoof, René A1 - Hebel, Christoph A1 - Merkens, Torsten T1 - Sektorenkopplung als Herausforderung und Chance für das Energieland NRW : Handlungsoptionen und Ergebnispapier der Expertengruppe AG 4 „Sektoren- kopplung“ im Netzwerk Netze und Speicher der EnergieAgentur.NRW im Auftrag des Landes Nordrhein-Westfalen / EnergieAgentur.NRW GmbH Y1 - 2018 ER - TY - JOUR A1 - Jung, Alexander A1 - Müller, Wolfram A1 - Staat, Manfred T1 - Wind and fairness in ski jumping: A computer modelling analysis JF - Journal of Biomechanics N2 - Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping. Y1 - 2018 U6 - https://doi.org/10.1016/j.jbiomech.2018.05.001 SN - 0021-9290 IS - 75 SP - 147 EP - 153 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Jung, Alexander A1 - Staat, Manfred A1 - Müller, Wolfram T1 - Corrigendum to “Flight style optimization in ski jumping on normal, large, and ski flying hills” [J. Biomech 47 (2014) 716–722] JF - Journals of Biomechanics Y1 - 2018 U6 - https://doi.org/10.1016/j.jbiomech.2018.02.001 SN - 0021-9290 N1 - refers to Journal of Biomechanics Vol 47, Issue 3, Pages 716-722: https://doi.org/10.1016/j.jbiomech.2013.11.021 SP - 313 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Jabbari, Medisa A1 - Anding, Ralf A1 - Staat, Manfred T1 - Surgical treatment of vaginal vault prolapse using different prosthetic mesh implants: a finite element analysis JF - tm - Technisches Messen N2 - Particularly multiparous elderly women may suffer from vaginal vault prolapse after hysterectomy due to weak support from lax apical ligaments. A decreased amount of estrogen and progesterone in older age is assumed to remodel the collagen thereby reducing tissue stiffness. Sacrocolpopexy is either performed as open or laparoscopic surgery using prosthetic mesh implants to substitute lax ligaments. Y-shaped mesh models (DynaMesh, Gynemesh, and Ultrapro) are implanted in a 3D female pelvic floor finite element model in the extraperitoneal space from the vaginal cuff to the first sacral (S1) bone below promontory. Numerical simulations are conducted during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues are modeled as incompressible, isotropic hyperelastic materials whereas the meshes are modeled either as orthotropic linear elastic or as isotropic hyperlastic materials. The positions of the vaginal cuff and the bladder base are calculated from the pubococcygeal line for female pelvic floor at rest, for prolapse and after repair using the three meshes. Due to mesh mechanics and mesh pore deformation along the loaded direction, the DynaMesh with regular rectangular mesh pores is found to provide better mechanical support to the organs than the Gynemesh and the Ultrapro with irregular hexagonal mesh pores. Insbesondere ältere, mehrgebährende Frauen leiden häufiger an einem Scheidenvorfall nach einer Hysterektomie aufgrund der schwachen Unterstützung durch laxe apikale Bänder. Es wird angenommen, dass eine verringerte Menge an Östrogen und Progesteron im höheren Alter das Kollagen umformt, wodurch die Gewebesteifigkeit reduziert wird. Die Sakrokolpopexie ist eine offene oder laparoskopische Operation, die mit prothetischen Netzimplantaten durchgeführt wird, um laxe Bänder zu ersetzen. Y-förmige Netzmodelle (DynaMesh, Gynemesh und Ultrapro) werden in einem 3D-Modell des weiblichen Beckenbodens im extraperitonealen Raum vom Vaginalstumpf bis zum Promontorium implantiert. Numerische Simulationen werden während des Valsalva-Manövers mit geschwächtem Gewebe durchgeführt, das durch eine reduzierte Gewebesteifigkeit modelliert wird. Die Gewebe werden als inkompressible, isotrop hyperelastische Materialien modelliert, während die Netze entweder als orthotrope linear elastische oder als isotrope hyperlastische Materialien modelliert werden. Die Positionen des Vaginalstumpfs, der Blase und der Harnröhrenachse werden anhand der Pubococcygeallinie aus der Ruhelage, für den Prolaps und nach der Reparatur unter Verwendung der drei Netze berechnet. Aufgrund der Netzmechanik und der Netzporenverformung bietet das DynaMesh mit regelmäßigen rechteckigen Netzporen eine bessere mechanische Unterstützung und eine Neupositionierung des Scheidengewölbes, der Blase und der Urethraachse als Gynemesh und Ultrapro mit unregelmäßigen hexagonalen Netzporen. Y1 - 2018 U6 - https://doi.org/10.1515/teme-2017-0115 SN - 2196-7113 VL - 85 IS - 5 SP - 331 EP - 342 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Valero, Daniel A1 - Bung, Daniel Bernhard T1 - Reformulating self-aeration in hydraulic structures: Turbulent growth of free surface perturbations leading to air entrainment JF - International Journal of Multiphase Flow N2 - A new formulation for the prediction of free surface dynamics related to the turbulence occurring nearby is proposed. This formulation, altogether with a breakup criterion, can be used to compute the inception of self-aeration in high velocity flows like those occurring in hydraulic structures. Assuming a simple perturbation geometry, a kinematic and a non-linear momentum-based dynamic equation are formulated and forces acting on a control volume are approximated. Limiting steepness is proposed as an adequate breakup criterion. Role of the velocity fluctuations normal to the free surface is shown to be the main turbulence quantity related to self-aeration and the role of the scales contained in the turbulence spectrum are depicted. Surface tension force is integrated accounting for large displacements by using differential geometry for the curvature estimation. Gravity and pressure effects are also contemplated in the proposed formulation. The obtained equations can be numerically integrated for each wavelength, hence resulting in different growth rates and allowing computation of the free surface roughness wavelength distribution. Application to a prototype scale spillway (at the Aviemore dam) revealed that most unstable wavelength was close to the Taylor lengthscale. Amplitude distributions have been also obtained observing different scaling for perturbations stabilized by gravity or surface tension. The proposed theoretical framework represents a new conceptualization of self-aeration which explains the characteristic rough surface at the non-aerated region as well as other previous experimental observations which remained unresolved for several decades. Y1 - 2018 U6 - https://doi.org/10.1016/j.ijmultiphaseflow.2017.12.011 SN - 0301-9322 VL - 100 SP - 127 EP - 142 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Birgel, Stefan A1 - Leschinger, Tim A1 - Wegmann, Kilian A1 - Staat, Manfred T1 - Calculation of muscle forces and joint reaction loads in the shoulder area via an OpenSim based computer model JF - tm - Technisches Messen N2 - Using the OpenSim software and verified anatomical data, a computer model for the calculation of biomechanical parameters is developed and used to determine the effect of a reattachment of the Supraspinatus muscle with a medial displacement of the muscle attachment point, which may be necessary for a rupture of the supraspinatus tendon. The results include the influence of the operation on basic biomechanical parameters such as the lever arm, as well as the calculated the muscle activations for the supraspinatus and deltoid. In addition, the influence on joint stability is examined by an analysis of the joint reaction force. The study provides a detailed description of the used model, as well as medical findings to a reattachment of the supraspinatus. Mit der Software OpenSim und überprüften anatomischen Daten wird ein Computermodell zur Berechnung von biomechanischen Parametern entwickelt und genutzt, um den Effekt einer Refixierung des Supraspinatusmuskels mit einer medialen Verschiebung des Muskelansatzpunktes zu ermitteln, wie sie unter anderem nach einem Riss der Supraspinatussehne notwendig sein kann. Die Ergebnisse umfassen hierbei den Einfluss der Operation auf grundlegende biomechanische Parameter wie den Hebelarm sowie die berechneten Muskelaktivierungen für den Supraspinatus und Deltoideus. Zusätzlich wird der Einfluss auf die Gelenkstabilität betrachtet und durch eine Analyse der Gelenkreaktionskraft untersucht. Die Studie bietet eine detaillierte Beschreibung des genutzten Modells, sowie medizinische Erkenntnisse zu einer Refixierung des Supraspinatus. Y1 - 2018 U6 - https://doi.org/10.1515/teme-2017-0114 SN - 2196-7113 VL - 85 IS - 5 SP - 321 EP - 330 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Golland, Alexander T1 - Das neue kirchliche Datenschutzrecht – Herausforderungen für Unternehmen der Privatwirtschaft JF - DSB Datenschutz-Berater Y1 - 2018 SN - 0170-7256 VL - 42 IS - 9 SP - 179 EP - 181 PB - dfv Mediengruppe CY - Frankfurt a.M. ER - TY - BOOK A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Zhubanova, Azhar A. A1 - Digel, Ilya ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Biological, physical and technical basics of cell engineering Y1 - 2018 SN - 978-981-10-7903-0 PB - Springer CY - Singapore ER - TY - CHAP A1 - Müller-Abdelrazeq, Sarah Luisa A1 - Brauner, Philipp A1 - Calero Valdez, André A1 - Jansen, Ulrich A1 - Platte, Laura A1 - Schaar, Anne-Kathrin A1 - Steuer-Dankert, Linda A1 - Zachow, Sebastian A1 - Schönefeld, Kathrin A1 - Haberstroh, Max A1 - Leicht-Scholten, Carmen A1 - Ziefle, Martina ED - Pather, Shaun T1 - Interdisciplinary cooperation management in research clusters: a review of twelve years. T2 - Proceedings of the 15th International Conference on Intellectual Capital, Knowledge Management & Organisational Learning N2 - As an interdisciplinary research network, the Cluster of Excellence “Integrative Production Technology for High-Wage Countries” (CoE) comprises of around 150 researchers. Their scientific background ranges from mechanical engineering and computer science to social sciences such as sociology and psychology. In addition to content- and methodbased challenges, the CoE’s employees are faced with heterogenic organizational cultures, different hierarchical levels, an imbalanced gender distribution, and a high employee fluctuation. The sub-project Scientific Cooperation Engineering 1 (CSP1) addresses the challenge of interdisciplinary cooperation and organizational learning and aims at fostering interdisciplinarity and its synergies as a source of innovation. Therefore, the project examines means of reaching an organizational development, ranging from temporal structures to a sustainable network in production technology. To achieve this aim, a broad range of means has been developed during the last twelve years: In addition to physical measures such as regular network events and trainings, virtual measures such as the Terminology App were focused. The app is an algorithmic analysis method for uncovering latent topic structures of publications of the CoE to highlight thematic intersections and synergy potentials. The detection and promotion of has been a vital and long known element in knowledge management. Furthermore, CSP1 focusses on project management and thus developed evaluation tools to measure and control the success of interdisciplinary cooperation. In addition to the cooperation fostering measures, CSP1 conducted studies about interdisciplinarity and diversity and their relationship with innovation. The scientific background of these means and the research results of CSP1 are outlined in this paper to offer approaches for successful interdisciplinary cooperation management. Y1 - 2018 SN - 978-1-912764-09-9 N1 - hosted by University of the Western Cape, South Africa 29-30 November 2018 SP - 216 EP - 224 PB - ACPIL ER - TY - JOUR A1 - Engel, Mareike A1 - Holtmann, Dirk A1 - Ulber, Roland A1 - Tippkötter, Nils T1 - Increased Biobutanol Production by Mediator‐Less Electro‐Fermentation JF - Biotechnology Journal N2 - A future bio-economy should not only be based on renewable raw materials but also in the raise of carbon yields of existing production routes. Microbial electrochemical technologies are gaining increased attention for this purpose. In this study, the electro-fermentative production of biobutanol with C. acetobutylicum without the use of exogenous mediators is investigated regarding the medium composition and the reactor design. It is shown that the use of an optimized synthetic culture medium allows higher product concentrations, increased biofilm formation, and higher conductivities compared to a synthetic medium supplemented with yeast extract. Moreover, the optimization of the reactor system results in a doubling of the maximum product concentrations for fermentation products. When a working electrode is polarized at −600 mV vs. Ag/AgCl, a shift from butyrate to acetone and butanol production is induced. This leads to an increased final solvent yield of Yᴀᴃᴇ = 0.202 gg⁻¹ (control 0.103 gg⁻¹), which is also reflected in a higher carbon efficiency of 37.6% compared to 23.3% (control) as well as a fourfold decrease in simplified E-factor to 0.43. The results are promising for further development of biobutanol production in bioelectrochemical systems in order to fulfil the principles of Green Chemistry. Y1 - 2018 U6 - https://doi.org/10.1002/biot.201800514 SN - 1860-7314 VL - 14 IS - 4 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Fernandes, P.R. ED - Tavares, J. M. T1 - Pectopexy to repair vaginal vault prolapse: a finite element approach T2 - Proceedings CMBBE 2018 N2 - The vaginal prolapse after hysterectomy (removal of the uterus) is often associated with the prolapse of the vaginal vault, rectum, bladder, urethra or small bowel. Minimally invasive surgery such as laparoscopic sacrocolpopexy and pectopexy are widely performed for the treatment of the vaginal prolapse with weakly supported vaginal vault after hysterectomy using prosthetic mesh implants to support (or strengthen) lax apical ligaments. Implants of different shape, size and polymers are selected depending on the patient’s anatomy and the surgeon’s preference. In this computational study on pectopexy, DynaMesh®-PRP soft, GYNECARE GYNEMESH® PS Nonabsorbable PROLENE® soft and Ultrapro® are tested in a 3D finite element model of the female pelvic floor. The mesh model is implanted into the extraperitoneal space and sutured to the vaginal stump with a bilateral fixation to the iliopectineal ligament at both sides. Numerical simulations are conducted at rest, after surgery and during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues and prosthetic meshes are modeled as incompressible, isotropic hyperelastic materials. The positions of the organs are calculated with respect to the pubococcygeal line (PCL) for female pelvic floor at rest, after repair and during Valsalva maneuver using the three meshes. Y1 - 2018 N1 - 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and 3rd Conference on Imaging and Visualization. CMBBE 2018. 26-29 March 2018, Lisbon, Portugal ER - TY - CHAP A1 - Duwe, A. A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Lignocellulose-Biorefinery: Ethanol-Focused T2 - Biorefineries N2 - The development prospects of the world markets for petroleum and other liquid fuels are diverse and partly contradictory. However, comprehensive changes for the energy supply of the future are essential. Notwithstanding the fact that there are still very large deposits of energy resources from a geological point of view, the finite nature of conventional oil reserves is indisputable. To reduce our dependence on oil, the EU, the USA, and other major economic zones rely on energy diversification. For this purpose, alternative materials and technologies are being sought, and is most obvious in the transport sector. The objective is to progressively replace fossil fuels with renewable and more sustainable fuels. In this respect, biofuels have a pre-eminent position in terms of their capability of blending with fossil fuels and being usable in existing cars without substantial modification. Ethanol can be considered as the primary renewable liquid fuel. In this chapter enzymes, micro-organisms, and processes for ethanol production based on renewable resources are described. KW - Bioethanol KW - Biorefinery KW - Lignocellulose feedstook Y1 - 2018 U6 - https://doi.org/10.1007/10_2016_72 N1 - Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE,volume 166) SP - 177 EP - 215 PB - Springer CY - Cham ER - TY - JOUR A1 - Hüning, Felix A1 - Heuermann, Holger A1 - Wache, Franz-Josef T1 - Wireless CAN without WLAN or Bluetooth JF - CAN Newsletter N2 - In two developed concepts, dual-mode radio enables CAN participants to be integrated wirelessly into a CAN network. Constructed from a few components, a protocol-free, real-time transmission and thus transparent integration into CAN is provided. Y1 - 2018 IS - December 2018 SP - 44 EP - 46 ER - TY - JOUR A1 - Bhattarai, Aroj A1 - Staat, Manfred T1 - Modelling of Soft Connective Tissues to Investigate Female Pelvic Floor Dysfunctions JF - Computational and Mathematical Methods in Medicine N2 - After menopause, decreased levels of estrogen and progesterone remodel the collagen of the soft tissues thereby reducing their stiffness. Stress urinary incontinence is associated with involuntary urine leakage due to pathological movement of the pelvic organs resulting from lax suspension system, fasciae, and ligaments. This study compares the changes in the orientation and position of the female pelvic organs due to weakened fasciae, ligaments, and their combined laxity. A mixture theory weighted by respective volume fraction of elastin-collagen fibre compound (5%), adipose tissue (85%), and smooth muscle (5%) is adopted to characterize the mechanical behaviour of the fascia. The load carrying response (other than the functional response to the pelvic organs) of each fascia component, pelvic organs, muscles, and ligaments are assumed to be isotropic, hyperelastic, and incompressible. Finite element simulations are conducted during Valsalva manoeuvre with weakened tissues modelled by reduced tissue stiffness. A significant dislocation of the urethrovesical junction is observed due to weakness of the fascia (13.89 mm) compared to the ligaments (5.47 mm). The dynamics of the pelvic floor observed in this study during Valsalva manoeuvre is associated with urethral-bladder hypermobility, greater levator plate angulation, and positive Q-tip test which are observed in incontinent females. Y1 - 2018 U6 - https://doi.org/10.1155/2018/9518076 SN - 1748-6718 VL - 2018 IS - Article ID 9518076 SP - 1 EP - 16 PB - Hindawi CY - New York, NY ER - TY - JOUR A1 - Bung, Daniel Bernhard A1 - Valero, Daniel T1 - Re-aeration on stepped spillways with special consideration of entrained and entrapped air JF - Geosciences N2 - As with most high-velocity free-surface flows, stepped spillway flows become self-aerated when the drop height exceeds a critical value. Due to the step-induced macro-roughness, the flow field becomes more turbulent than on a similar smooth-invert chute. For this reason, cascades are oftentimes used as re-aeration structures in wastewater treatment. However, for stepped spillways as flood release structures downstream of deoxygenated reservoirs, gas transfer is also of crucial significance to meet ecological requirements. Prediction of mass transfer velocities becomes challenging, as the flow regime differs from typical previously studied flow conditions. In this paper, detailed air-water flow measurements are conducted on stepped spillway models with different geometry, with the aim to estimate the specific air-water interface. Re-aeration performances are determined by applying the absorption method. In contrast to earlier studies, the aerated water body is considered a continuous mixture up to a level where 75% air concentration is reached. Above this level, a homogenous surface wave field is considered, which is found to significantly affect the total air-water interface available for mass transfer. Geometrical characteristics of these surface waves are obtained from high-speed camera investigations. The results show that both the mean air concentration and the mean flow velocity have influence on the mass transfer. Finally, an empirical relationship for the mass transfer on stepped spillway models is proposed. Y1 - 2018 SN - 2076-3263 VL - 8 IS - 9 SP - Article number 333 PB - MDPI CY - Basel ER - TY - CHAP A1 - Digel, Ilya A1 - Akimbekov, Nuraly S. A1 - Kistaubayeva, Aida A1 - Zhubanova, Azhar A. ED - Artmann, Gerhard ED - Temiz Artmann, Aysegül ED - Zhubanova, Azhar A. ED - Digel, Ilya T1 - Microbial Sampling from Dry Surfaces: Current Challenges and Solutions T2 - Biological, Physical and Technical Basics of Cell Engineering N2 - Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms’ recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling. KW - Sampling methods KW - Surface microorganisms KW - Dry surfaces KW - Microbial adhesion KW - Swabbing Y1 - 2018 SN - 978-981-10-7904-7 U6 - https://doi.org/10.1007/978-981-10-7904-7_19 SP - 421 EP - 456 PB - Springer CY - Singapore ER - TY - JOUR A1 - Hofmann, Till A1 - Limpert, Nicolas A1 - Mataré, Victor A1 - Schönitz, Sebastian A1 - Niemueller, Tim A1 - Ferrein, Alexander A1 - Lakemeyer, Gerhard T1 - The Carologistics RoboCup Logistics Team 2018 N2 - The Carologistics team participates in the RoboCup Logistics League for the seventh year. The RCLL requires precise vision, manipulation and path planning, as well as complex high-level decision making and multi-robot coordination. We outline our approach with an emphasis on recent modifications to those components. The team members in 2018 are David Bosen, Christoph Gollok, Mostafa Gomaa, Daniel Habering, Till Hofmann, Nicolas Limpert, Sebastian Schönitz, Morian Sonnet, Carsten Stoffels, and Tarik Viehmann. This paper is based on the last year’s team description. Y1 - 2018 ER - TY - CHAP A1 - Jean-Pierre P., de Vera A1 - Baque, Mickael A1 - Billi, Daniela A1 - Böttger, Ute A1 - Bulat, Sergey A1 - Czupalla, Markus A1 - Dachwald, Bernd A1 - de la Torre, Rosa A1 - Elsaesser, Andreas A1 - Foucher, Frédéric A1 - Korsitzky, Hartmut A1 - Kozyrovska, Natalia A1 - Läufer, Andreas A1 - Moeller, Ralf A1 - Olsson-Francis, Karen A1 - Onofri, Silvano A1 - Sommer, Stefan A1 - Wagner, Dirk A1 - Westall, Frances T1 - The search for life on Mars and in the Solar System - strategies, logistics and infrastructures T2 - 69th International Astronautical Congress (IAC) N2 - The question "Are we alone in the Universe?" is perhaps the most fundamental one that affects mankind. How can we address the search for life in our Solar System? Mars, Enceladus and Europa are the focus of the search for life outside the terrestrial biosphere. While it is more likely to find remnants of life (fossils of extinct life) on Mars because of its past short time window of the surface habitability, it is probably more likely to find traces of extant life on the icy moons and ocean worlds of Jupiter and Saturn. Nevertheless, even on Mars there could still be a chance to find extant life in niches near to the surface or in just discovered subglacial lakes beneath the South Pole ice cap. Here, the different approaches for the detection of traces of life in the form of biosignatures including pre-biotic molecules will be presented. We will outline the required infrastructure for this enterprise and give examples of future mission concepts to investigate the presence of life on other planets and moons. Finally, we will provide suggestions on methods, techniques, operations and strategies for preparation and realization of future life detection missions. KW - life detection KW - Mars KW - icy moons KW - habitability KW - space missions Y1 - 2018 N1 - 69th International Astronautical Congress (IAC), Bremen, Germany, 1-5 October 2018. SP - 1 EP - 8 ER - TY - JOUR A1 - Digel, Ilya A1 - Wehlitz, V. A1 - Kayser, Peter A1 - Figiel-Lange, A. A1 - Bassam, R. A1 - Rundstedt, F. von T1 - Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids JF - Plant Pathology N2 - Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel ‘suspension depletion’ approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10–12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach. Y1 - 2018 U6 - https://doi.org/10.1111/ppa.12750 SN - 1365-3059 VL - 67 IS - 2 SP - 358 EP - 365 PB - Wiley CY - Oxford ER - TY - JOUR A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Kubalski, Thomas A1 - Fehling, Ekkehard A1 - Pfetzing, Thomas A1 - Meyer, Udo ED - Voss, Michael T1 - Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk (Teil 2) T1 - Design of reinforced concrete enclosures infilled with clay block masonry (Part 2) JF - Ziegelindustrie international : ZI = Brick and tile industry international N2 - Im Rahmen des europäischen Verbundprojekts INSYSME wurden von den deutschen Partnern die Systeme IMES und INODIS zur Verbesserung des seismischen Verhaltens von ausgefachten Stahlbetonrahmen entwickelt. Ziel beider Systeme ist es, Stahlbetonrahmen und Ausfachung zu entkoppeln, anstatt die Tragfähigkeit durch aufwendige und kostspielige zusätzliche Bewehrungseinlagen zu erhöhen. Erste Ergebnisse des Systems IMES für Belastungen in und senkrecht zu der Wandebene werden vorgestellt. N2 - Within the scope of the joint European project INSYSME, the German partners developed two systems - IMES and INODIS - for improving the seismic behaviour of masonry infilled reinforced concrete frames. The purpose of both systems is to decouple frame and infill instead of working to improve their load-bearing capacity by means of elaborate, expensive, supplementary reinforcing elements. Initial findings for the IMES system with regard to the loads acting in-plane and perpendicular to the wall plane (out-of-plane) are presented. Y1 - 2018 SN - 0341-0552 IS - 6 SP - 24 EP - 43 PB - Bauverlag BV GmbH CY - Gütersloh ER - TY - JOUR A1 - Wollert, Jörg T1 - TSN – Schluss mit dem Feldbuskrieg? JF - Design & Elektronik Y1 - 2018 SN - 0933-8667 N1 - Echtzeit für Industrie 4.0. - Teil 3 IS - 3 SP - 26 EP - 31 PB - WEKA-Fachmedien CY - München ER - TY - BOOK A1 - Timme, Michael T1 - BGB Crashkurs: der sichere Weg durch die Prüfung Y1 - 2018 SN - 978-3-406-72251-6 PB - C.H. Beck CY - München ET - 5. Auflage ER - TY - JOUR A1 - Welden, Rene A1 - Scheja, Sabrina A1 - Schöning, Michael Josef A1 - Wagner, Patrick A1 - Wagner, Torsten T1 - Electrochemical Evaluation of Light‐Addressable Electrodes Based on TiO2 for the Integration in Lab‐on‐Chip Systems JF - physica status solidi a : applications and materials sciences N2 - In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol–gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated. Y1 - 2018 U6 - https://doi.org/10.1002/pssa.201800150 SN - 1862-6319 VL - 215 IS - 15 SP - Article number 1800150 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Michaux, F. A1 - Mattern, P. A1 - Kallweit, Stephan T1 - RoboPIV: how robotics enable PIV on a large industrial scale JF - Measurement Science and Technology N2 - This work demonstrates how the interaction between particle image velocimetry (PIV) and robotics can massively increase measurement efficiency. The interdisciplinary approach is shown using the complex example of an automated, large scale, industrial environment: a typical automotive wind tunnel application. Both the high degree of flexibility in choosing the measurement region and the complete automation of stereo PIV measurements are presented. The setup consists of a combination of three robots, individually used as a 6D traversing unit for the laser illumination system as well as for each of the two cameras. Synchronised movements in the same reference frame are realised through a master-slave setup with a single interface to the user. By integrating the interface into the standard wind tunnel management system, a single measurement plane or a predefined sequence of several planes can be requested through a single trigger event, providing the resulting vector fields within minutes. In this paper, a brief overview on the demands of large scale industrial PIV and the existing solutions is given. Afterwards, the concept of RoboPIV is introduced as a new approach. In a first step, the usability of a selection of commercially available robot arms is analysed. The challenges of pose uncertainty and importance of absolute accuracy are demonstrated through comparative measurements, explaining the individual pros and cons of the analysed systems. Subsequently, the advantage of integrating RoboPIV directly into the existing wind tunnel management system is shown on basis of a typical measurement sequence. In a final step, a practical measurement procedure, including post-processing, is given by using real data and results. Ultimately, the benefits of high automation are demonstrated, leading to a drastic reduction in necessary measurement time compared to non-automated systems, thus massively increasing the efficiency of PIV measurements. Y1 - 2018 U6 - https://doi.org/10.1088/1361-6501/aab5c1 SN - 1361-6501 N1 - Special Section on the 12th International Symposium on Particle Image Velocimetry (PIV 2017) VL - 29 IS - 7 SP - 074009 PB - IOP CY - Bristol ER - TY - CHAP A1 - Schulze, Sven A1 - Mühleisen, M. A1 - Feyerl, Günter T1 - Adaptive energy management strategy for a heavy-duty truck with a P2-hybrid topology T2 - 18. Internationales Stuttgarter Symposium. Proceedings Y1 - 2018 U6 - https://doi.org/10.1007/978-3-658-21194-3 SP - 75 EP - 89 PB - Springer Vieweg CY - Wiesbaden ER - TY - JOUR A1 - Jildeh, Zaid B. A1 - Oberländer, Jan A1 - Kirchner, Patrick A1 - Wagner, Patrick H. A1 - Schöning, Michael Josef T1 - Thermocatalytic Behavior of Manganese (IV) Oxide as Nanoporous Material on the Dissociation of a Gas Mixture Containing Hydrogen Peroxide JF - Nanomaterials N2 - In this article, we present an overview on the thermocatalytic reaction of hydrogen peroxide (H₂O₂) gas on a manganese (IV) oxide (MnO₂) catalytic structure. The principle of operation and manufacturing techniques are introduced for a calorimetric H₂O₂ gas sensor based on porous MnO₂. Results from surface analyses by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) of the catalytic material provide indication of the H₂O₂ dissociation reaction schemes. The correlation between theory and the experiments is documented in numerical models of the catalytic reaction. The aim of the numerical models is to provide further information on the reaction kinetics and performance enhancement of the porous MnO₂ catalyst. Y1 - 2018 U6 - https://doi.org/10.3390/nano8040262 SN - 2079-4991 VL - 8 IS - 4 PB - MDPI CY - Basel ER - TY - JOUR A1 - Fissabre, Anke A1 - Wilson, Ariane T1 - Der Turm mit zehn Spornen – Ein in Monthoiron gebauter Entwurf von Leonardo Da Vinci? JF - In situ: Zeitschrift für Architekturgeschichte Y1 - 2018 SN - 1866-959X N1 - gedruckt in der Bereichsbibliothek Bayernallee vorhanden. Signatur 13 Z 959-2018 IS - 1 SP - 65 EP - 82 PB - Wernersche Verlagsgesellschaft CY - Worms ER - TY - JOUR A1 - Aboulnaga, E. A. A1 - Zou, H. A1 - Selmer, Thorsten A1 - Xian, M. T1 - Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16 JF - Journal of Biotechnology N2 - Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism. As applications of the expression system in C. necator H16, the growth ability on glycerol was enhanced by constitutively expressing the E. coli glpk gene-encoding for glycerol kinase. Likewise, we used the system to overcome the expression toxicity of mevalonate pathway in C. necator H16. With this system, the mevalonate-genes were successfully introduced in the host and the recombinant strains could produce about 200 mg/l mevalonate. Y1 - 2018 U6 - https://doi.org/10.1016/j.jbiotec.2018.03.007 SN - 0168-1656 VL - 274 SP - 15 EP - 27 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Röth, Thilo A1 - Pielen, Michael A1 - Wolff, Klaus A1 - Lüdiger, Thomas T1 - Urbane Fahrzeugkonzepte für die Shared Mobility JF - Automobiltechnische Zeitschrift - ATZ N2 - Urbane Mobilitätskonzepte der Zukunft erfordern neue Unternehmensformen, idealerweise aus Old Economy und New Economy, sowie eine enge Anbindung an die gesellschaftsrelevante Zukunftsforschung. Für neue Fahrzeugkonzepte des Carsharing bedeutet dies, dass alle kostenverursachenden Faktoren erfasst und analysiert werden müssen. Die FH Aachen, share2drive und FEV geben einen Ausblick auf die zukünftige Fahrzeugklasse der Personal Public Vehicles als „Rolling Device“. Y1 - 2018 U6 - https://doi.org/10.1007/s35148-017-0176-8 SN - 0001-2785 VL - 120 IS - 1 SP - 18 EP - 23 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Scholl, Ingrid A1 - Suder, Sebastian A1 - Schiffer, Stefan T1 - Direct Volume Rendering in Virtual Reality T2 - Bildverarbeitung für die Medizin 2018 Y1 - 2018 SN - 978-3-662-56537-7 U6 - https://doi.org/10.1007/978-3-662-56537-7_79 SP - 297 EP - 302 PB - Springer Vieweg CY - Berlin ER - TY - JOUR A1 - Schirra, Julian A1 - Bissonnette, William A1 - Bramesfeld, Götz T1 - Wake-model effects on induced drag prediction of staggered boxwings JF - Aerospace Y1 - 2018 U6 - https://doi.org/10.3390/aerospace5010014 SN - 2226-4310 VL - 5 IS - 1 ER - TY - JOUR A1 - Druckenmüller, Katharina A1 - Günther, Klaus A1 - Elbers, Gereon T1 - Near-infrared spectroscopy (NIRS) as a tool to monitor exhaust air from poultry operations JF - Science of the Total Environment N2 - Intensive poultry operation systems emit a considerable volume of inorganic and organic matter in the surrounding environment. Monitoring cleaning properties of exhaust air cleaning systems and to detect small but significant changes in emission characteristics during a fattening cycle is important for both emission and fattening process control. In the present study, we evaluated the potential of near-infrared spectroscopy (NIRS) combined with chemometric techniques as a monitoring tool of exhaust air from poultry operation systems. To generate a high-quality data set for evaluation, the exhaust air of two poultry houses was sampled by applying state-of-the-art filter sampling protocols. The two stables were identical except for one crucial difference, the presence or absence of an exhaust air cleaning system. In total, twenty-one exhaust air samples were collected at the two sites to monitor spectral differences caused by the cleaning device, and to follow changes in exhaust air characteristics during a fattening period. The total dust load was analyzed by gravimetric determination and included as a response variable in multivariate data analysis. The filter samples were directly measured with NIR spectroscopy. Principal component analysis (PCA), linear discriminant analysis (LDA), and factor analysis (FA) were effective in classifying the NIR exhaust air spectra according to fattening day and origin. The results indicate that the dust load and the composition of exhaust air (inorganic or organic matter) substantially influence the NIR spectral patterns. In conclusion, NIR spectroscopy as a tool is a promising and very rapid way to detect differences between exhaust air samples based on still not clearly defined circumstances triggered during a fattening period and the availability of an exhaust air cleaning system. Y1 - 2018 U6 - https://doi.org/10.1016/j.scitotenv.2018.02.072 SN - 0048-9697 VL - 630 SP - 536 EP - 543 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Hüning, Felix T1 - Embedded Design For IoT With Renesas Synergy Y1 - 2018 N1 - gedruckt in der Bereichsbibliothek Eupener Str. vorhanden; Document No. R01PF0164ED0100 PB - Renesas Electronics CY - Düsseldorf ER - TY - JOUR A1 - Wollert, Jörg T1 - Echtzeit-Ethernet – Basis für Industrie 4.0 JF - Design & Elektronik Y1 - 2018 SN - 0933-8667 N1 - Echtzeit für Industrie 4.0. - Teil 2 PB - WEKA-Fachmedien CY - München ER - TY - JOUR A1 - Pilas, Johanna A1 - Yazici, Y. A1 - Selmer, Thorsten A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Application of a portable multi-analyte biosensor for organic acid determination in silage JF - Sensors N2 - Multi-analyte biosensors may offer the opportunity to perform cost-effective and rapid analysis with reduced sample volume, as compared to electrochemical biosensing of each analyte individually. This work describes the development of an enzyme-based biosensor system for multi-parametric determination of four different organic acids. The biosensor array comprises five working electrodes for simultaneous sensing of ethanol, formate, d-lactate, and l-lactate, and an integrated counter electrode. Storage stability of the biosensor was evaluated under different conditions (stored at +4 °C in buffer solution and dry at −21 °C, +4 °C, and room temperature) over a period of 140 days. After repeated and regular application, the individual sensing electrodes exhibited the best stability when stored at −21 °C. Furthermore, measurements in silage samples (maize and sugarcane silage) were conducted with the portable biosensor system. Comparison with a conventional photometric technique demonstrated successful employment for rapid monitoring of complex media. Y1 - 2018 U6 - https://doi.org/10.3390/s18051470 SN - 1424-8220 VL - 18 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Dantism, Shahriar A1 - Röhlen, Desiree A1 - Wagner, Torsten A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Optimization of Cell-Based Multi-Chamber LAPS Measurements Utilizing FPGA-Controlled Laser-Diode Modules JF - physica status solidi a : applications and materials sciences N2 - A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric device, which detects concentration changes of an analyte solution on the sensor surface in a spatially resolved way. It uses a light source to generate electron–hole pairs inside the semiconductor, which are separated in the depletion region due to an applied bias voltage across the sensor structure and hence, a surface-potential-dependent photocurrent can be read out. However, depending on the beam angle of the light source, scattering effects can occur, which influence the recorded signal in LAPS-based differential measurements. To solve this problem, a novel illumination unit based on a field programmable gate array (FPGA) consisting of 16 small-sized tunable infrared laser-diode modules (LDMs) is developed. Due to the improved focus of the LDMs with a beam angle of only 2 mrad, undesirable scattering effects are minimized. Escherichia coli (E. coli) K12 bacteria are used as a test microorganism to study the extracellular acidification on the sensor surface. Furthermore, a salt bridge chamber is built up and integrated with the LAPS system enabling multi-chamber differential measurements with a single Ag/AgCl reference electrode. Y1 - 2018 U6 - https://doi.org/10.1002/pssa.201800058 SN - 1862-6319 VL - 215 IS - 15 SP - Article number 1800058 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Schreiber, Marc A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - NLP Lean Programming Framework: Developing NLP Applications More Effectively T2 - Proceedings of NAACL-HLT 2018: Demonstrations, New Orleans, Louisiana, June 2 - 4, 2018 N2 - This paper presents NLP Lean Programming framework (NLPf), a new framework for creating custom natural language processing (NLP) models and pipelines by utilizing common software development build systems. This approach allows developers to train and integrate domain-specific NLP pipelines into their applications seamlessly. Additionally, NLPf provides an annotation tool which improves the annotation process significantly by providing a well-designed GUI and sophisticated way of using input devices. Due to NLPf’s properties developers and domain experts are able to build domain-specific NLP applications more efficiently. NLPf is Opensource software and available at https:// gitlab.com/schrieveslaach/NLPf. Y1 - 2018 U6 - https://doi.org/10.18653/v1/N18-5001  ER - TY - JOUR A1 - Vahidpour, Farnoosh A1 - Oberländer, Jan A1 - Schöning, Michael Josef T1 - Flexible Calorimetric Gas Sensors for Detection of a Broad Concentration Range of Gaseous Hydrogen Peroxide: A Step Forward to Online Monitoring of Food-Package Sterilization Processes JF - Phys. Status Solidi A N2 - In this study, flexible calorimetric gas sensors are developed for specificdetection of gaseous hydrogen peroxide (H₂O₂) over a wide concentrationrange, which is used in sterilization processes for aseptic packaging industry.The flexibility of these sensors is an advantage for identifying the chemical components of the sterilant on the corners of the food boxes, so-called “coldspots”, as critical locations in aseptic packaging, which are of great importance. These sensors are fabricated on flexible polyimide films by means of thin-film technique. Thin layers of titanium and platinum have been deposited on polyimide to define the conductive structures of the sensors. To detect the high-temperature evaporated H₂O₂, a differential temperature set-up is proposed. The sensors are evaluated in a laboratory-scaled sterilizationsystem to simulate the sterilization process. The concentration range of the evaporated H₂O₂ from 0 to 7.7% v/v was defined and the sensors have successfully detected high as well as low H₂O₂ concentrations with a sensitivity of 5.04 °C/% v/v. The characterizations of the sensors confirm their precise fabrication, high sensitivity and the novelty of low H₂O₂ concentration detections for future inline monitoring of food-package sterilization. Y1 - 2018 U6 - https://doi.org/10.1002/pssa.201800044 VL - 215 IS - 15 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Kunkel, Maximilian Hugo A1 - Gebhardt, Andreas A1 - Mpofu, Khumbaulani A1 - Kallweit, Stephan T1 - Statistical assessment of mechanical properties of selective laser melted specimens of stainless steel JF - The International Journal of Advanced Manufacturing Technology N2 - The rail business is challenged by long product life cycles and a broad spectrum of assembly groups and single parts. When spare part obsolescence occurs, quick solutions are needed. A reproduction of obsolete parts is often connected to long waiting times and minimum lot quantities that need to be purchased and stored. Spare part storage is therefore challenged by growing stocks, bound capital and issues of part ageing. A possible solution could be a virtual storage of spare parts which will be 3D printed through additive manufacturing technologies in case of sudden demand. As mechanical properties of additive manufactured parts are neither guaranteed by machine manufacturers nor by service providers, the utilization of this relatively young technology is impeded and research is required to address these issues. This paper presents an examination of mechanical properties of specimens manufactured from stainless steel through the selective laser melting (SLM) process. The specimens were produced in multiple batches. This paper interrogates the question if the test results follow a normal distribution pattern and if mechanical property predictions can be made. The results will be put opposite existing threshold values provided as the industrial standard. Furthermore, probability predictions will be made in order to examine the potential of the SLM process to maintain state-of-the-art mechanical property requirements. Y1 - 2018 U6 - https://doi.org/10.1007/s00170-018-2040-8 SN - 0268-3768 VL - 98 IS - 5-8 SP - 1409 EP - 1431 PB - Springer CY - London ER - TY - JOUR A1 - Wilson, C. E. A1 - Dickie, A. P. A1 - Schreiter, K. A1 - Wehr, R. A1 - Wilson, E. M. A1 - Bial, J. A1 - Scheer, Nico A1 - Wilson, I. D. A1 - Riley, R. J. T1 - The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice JF - Archives of Toxicology N2 - The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans. Y1 - 2018 U6 - https://doi.org/10.1007/s00204-018-2212-1 SN - 1432-0738 VL - 92 IS - 6 SP - 1953 EP - 1967 PB - Springer ER - TY - CHAP A1 - Bindzus, Manuel A1 - Bragard, Michael T1 - Motivating Intuitive Understanding of the Switched Reluctance Machine in the Education of Undergraduate Students T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - https://doi.org/10.1109/RTUCON.2018.8659870 SP - 1 EP - 6 ER - TY - CHAP A1 - Bragard, Michael A1 - Hoek, Hauke van A1 - Hoegen, Anne von A1 - Doncker, Rik W. De T1 - Motivation-based Learning: Teaching Fundamentals of Electrical Engineering with an LED Spinning Top T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - https://doi.org/10.1109/RTUCON.2018.8659810 SP - 1 EP - 6 ER - TY - CHAP A1 - Rütters, René A1 - Weinheimer, Marius A1 - Bragard, Michael T1 - Teaching Control Theory with a Simplified Helicopter Model and a Classroom Fitting Hardware Test-Bench T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - https://doi.org/10.1109/RTUCON.2018.8659871 ER - TY - JOUR A1 - Jochim, Haldor E. A1 - Menzel, Christoph J. T1 - Die Trassenbündelung als Planungsmethode nachhaltiger Verkehrspolitik JF - Der Eisenbahningenieur : EI Y1 - 2018 SN - 0013-2810 VL - 69 IS - 11 SP - 26 EP - 31 PB - DVV Media Group CY - Hamburg ER - TY - JOUR A1 - Klubert, Joachim A1 - Malecha, Hartmut A1 - Sparla, Peter T1 - Modernisierung der geodätischen Messtechnik der Urfttalsperre JF - Wasserwirtschaft T2 - Modernisation of the geodetic measurement technology of the Urft dam Y1 - 2018 SN - 0043-0978 N1 - gedruckt in der Bereichsbibliothek Bayernallee vorhanden VL - 108 IS - 10 SP - 14 EP - 18 PB - Springer Vieweg CY - Wiesbaden ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Roeth, Anjali A.J. A1 - Eberbeck, Dietmar A1 - Buhl, Eva Miriam A1 - Neumann, Ulf Peter A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells JF - Scientific Reports N2 - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells. Y1 - 2018 U6 - https://doi.org/10.1038/s41598-018-31553-9 SN - 2045-2322 VL - 8 IS - 1 SP - Article number 13210 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Buhl, Eva Miriam A1 - Draack, Sebastian A1 - Viereck, Thilo A1 - Frank, A1 - Schmitz-Rode, Thomas A1 - Slabu, Ioana T1 - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications JF - IEEE Magnetic Letters N2 - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy. Y1 - 2018 U6 - https://doi.org/10.1109/LMAG.2018.2879034 SN - 1949-307X VL - 9 IS - Article number 8519617 PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Foitschik, Tina A1 - Rojas-Vega, Sandra A1 - Strüder, Heiko K. T1 - Kinematics and kinetics of handcycling propulsion at increasing workloads in able-bodied subjects JF - Sports Engineereing N2 - In Paralympic sports, biomechanical optimisation of movements and equipment seems to be promising for improving performance. In handcycling, information about the biomechanics of this sport is mainly provided by case studies. The aim of the current study was (1) to examine changes in handcycling propulsion kinematics and kinetics due to increasing workloads and (2) identify parameters that are associated with peak aerobic performance. Twelve non-disabled male competitive triathletes without handcycling experience voluntarily participated in the study. They performed an initial familiarisation protocol and incremental step test until exhaustion in a recumbent racing handcycle that was attached to an ergometer. During the incremental test, tangential crank kinetics, 3D joint kinematics, blood lactate and ratings of perceived exertion (local and global) were identified. As a performance criterion, the maximal power output during the step test (Pmax) was calculated and correlated with biomechanical parameters. For higher workloads, an increase in crank torque was observed that was even more pronounced in the pull phase than in the push phase. Furthermore, participants showed an increase in shoulder internal rotation and abduction and a decrease in elbow flexion and retroversion. These changes were negatively correlated with performance. At high workloads, it seems that power output is more limited by the transition from pull to push phase than at low workloads. It is suggested that successful athletes demonstrate small alterations of their kinematic profile due to increasing workloads. Future studies should replicate and expand the test spectrum (sprint and continuous loads) as well as use methods like surface electromyography (sEMG) with elite handcyclists. Y1 - 2018 U6 - https://doi.org/10.1007/s12283-018-0269-y SN - 1460-2687 VL - 21 IS - 21 SP - 283 EP - 294 PB - Springer Nature CY - Cham ER -