TY - JOUR A1 - Prielmeier, Franz A1 - Merboldt, K. D. A1 - Hanicke, W. A1 - Frahm, J. T1 - Dynamic high-resolution MR imaging of brain deoxygenation during transient anoxia in the anesthetized rat JF - Journal of cerebral blood flow and metabolism. 13 (1993), H. 5 Y1 - 1993 SN - 0271-678X SP - 889 EP - 894 ER - TY - JOUR A1 - Prielmeier, Franz A1 - Nagatomo, Yasushi A1 - Wick, Markus A1 - Frahm, Jens T1 - Dynamic monitoring of cerebral metabolites during and after transient global ischemia in rats by quantitative proton NMR spectroscopy in vivo / Yasushi Nagatomo, Markus Wick, Franz Prielmeier, Jens Frahm JF - NMR in Biomedicine. 8 (1995), H. 6 Y1 - 1995 SN - 1099-1492 SP - 265 EP - 270 ER - TY - JOUR A1 - Abulnaga, El-Hussiny A1 - Pinkenburg, Olaf A1 - Schiffels, Johannes A1 - E-Refai, Ahmed A1 - Buckel, Wolfgang A1 - Selmer, Thorsten T1 - Effect of an Oxygen-Tolerant Bifurcating Butyryl Coenzyme A Dehydrogenase/Electron-Transferring Flavoprotein Complex from Clostridium difficile on Butyrate Production in Escherichia coli JF - Journal of bacteriology Y1 - 2013 SN - 1098-5530 [E-Journal] SN - 0021-9193 [Print] VL - 195 IS - 16 SP - 3704 EP - 3713 ER - TY - JOUR A1 - Heinze, D. A1 - Mang, Thomas A1 - Popescu, C. A1 - Weichold, O. T1 - Effect of side chain length and degree of polymerization on the decomposition and crystallization behaviour of chlorinated poly(vinyl ester) oligomers JF - Thermochimica Acta N2 - Four members of a homologous series of chlorinated poly(vinyl ester) oligomers CCl₃–(CH₂CH (OCO(CH₂)ₘCH₃))ₙ–Cl with degrees of polymerization of 10 and 20 were prepared by telomerisation using carbon tetrachloride. The number of side chain carbon atoms ranges from 2 (poly(vinyl acetate) to 18 (poly(vinyl stearate)). The effect of the n-alkyl side chain length and of the degree of polymerization on the thermal stability and crystallization behaviour of the synthesized compounds was investigated. All oligomers degrade in two major steps by first losing HCl and side chains with subsequent breakdown of the backbone. The members with short side chains, up to poly(vinyl octanoate), are amorphous and show internal plasticization, whereas those with high number of side chain carbon atoms are semi-crystalline due to side-chain crystallization. A better packing for poly(vinyl stearate) is also noticeable. The glass transition and melting temperatures as well as the onset temperature of decomposition are influenced to a larger extent by the side chain length than by the degree of polymerization. Thermal stability is improved if both the size and number of side chains increase, but only a long side chain causes a significant increase of the resistance to degradation. This results in a stabilization of PVAc so that oligomers from poly(vinyl octanoate) on are stable under atmospheric conditions. Thus, the way to design stable, chlorinated PVEs oligomers is to use a long n-alkyl side chain. Y1 - 2016 U6 - http://dx.doi.org/10.1016/j.tca.2016.05.015 SN - 0040-6031 (electronic) VL - 637 SP - 143 EP - 153 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Cehreli, Ruksan A1 - Akpinar, Hale A1 - Temiz Artmann, Aysegül A1 - Sagol, Ozgul T1 - Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis JF - Gastroenterology Research Y1 - 2015 U6 - http://dx.doi.org/10.14740/gr683w SN - 1918-2813 VL - 8 IS - 5 SP - 265 EP - 273 ER - TY - JOUR A1 - Baumann, Marcus A1 - Thomas, D. A1 - Gleitz, M. T1 - Efficiency of carbon assimilation and photoacclimation in a small unicellular Chaetoceros species from the Weddel Sea (Antarctica): Influence of temperature and irridiance / Thomas, D. ; Baumann, M.E.M. ; Gleitz, M. JF - Journal of Experimental Marine Biology and Ecology. 157 (1992), H. 2 Y1 - 1992 SN - 0022-0981 SP - 195 EP - 209 ER - TY - JOUR A1 - Iber, Michaela A1 - Schübeler, Dirk A1 - Seibler, Jost A1 - Höxter, Maria A1 - Bode, Jürgen T1 - Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions JF - Technical Tips Online Y1 - 1998 U6 - http://dx.doi.org/10.1016/S1366-2120(08)70132-6 VL - 4 IS - 1 SP - 25 EP - 29 ER - TY - CHAP A1 - Berndt, Heinz A1 - Kalbe, Jochen A1 - Kuropka, Rolf A1 - Meyer-Stork, L. Sebastian A1 - Sauter, S. L. A1 - Höcker, Hartwig T1 - Eindeutige Charakterisierung von Tierhaaren und Tierhaar-Mischungen durch DNA-Analytik T2 - Beiträge zur 15. Gemeinsamen Tagung der Aachener Textilforschungsinstitute und des "Wollfadens", zugleich 32. Arbeitstagung des Deutschen Wollforschungsinstitutes an der Technischen Hochschule Aachen : am 06. und 07. Oktober 1988. - (Schriftenreihe des Deutschen Wollforschungsinstituts an der Technischen Hochschule Aachen e. V. ; 104) Y1 - 1989 SN - 0930-3723 SP - 29 EP - 32 PB - Dt. Wollforschungsinst. CY - Aachen ER - TY - JOUR A1 - Meyer-Stork, L. Sebastian A1 - Kalbe, Jochen A1 - Kuropka, Rolf A1 - Sauter, S. L. A1 - Höcker, Hartwig A1 - Berndt, Heinz T1 - Eindeutige Provenienzanalyse von Wolle und feinen Tierhaaren mit Hilfe der Erbsubstanz (DNS) JF - Textilveredlung : schweizerische Zeitschrift für Textilchemie, Textilveredlung und deren Randgebiete Y1 - 1988 SN - 0040-5310 VL - 23 IS - 9 SP - 304 EP - 307 ER - TY - JOUR A1 - Kotter, Michael A1 - Kirch, M. A1 - Riekert, Lothar T1 - Einfluß von Dispersion und Vorgeschichte dispersen Nickels auf dessen katalytische Eigenschaften bei der Hydrierung von Benzol, CO2 und CO / R. Kirch ; M. Kotter ; L. Riekert JF - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 88 (1984) Y1 - 1984 SN - 0005-9021 SP - 1054 EP - 1057 ER - TY - BOOK A1 - Lauth, Jakob A1 - Kowalczyk, Jürgen T1 - Einführung in die Physik und Chemie der Grenzflächen und Kolloide Y1 - 2016 SN - 978-3-662-47018-3 U6 - http://dx.doi.org/10.1007/978-3-662-47018-3 PB - Springer CY - Berlin ER - TY - JOUR A1 - Mang, Thomas T1 - Elastomere zum Abdichten gegen drückendes Wasser JF - Summaries : June 30 to July 3, 2003, Nürnberg = Kurzfassungen Y1 - 2003 N1 - Internationale Kautschuk-Tagung ; <2003 : ; 2003.06.30-07.03 : ; Nürnberg> ; International Rubber Conference<2003, Nürnberg> SP - 121 EP - 123 PB - DKG, Dt. Kautschuk-Ges. CY - Frankfurt, Main ER - TY - JOUR A1 - Mang, Thomas T1 - Elastomere zum Abdichten gegen drückendes Wasser JF - Kautschuk Gummi Kunststoffe. 57 (2004), H. 4 Y1 - 2004 SN - 0022-9520 SP - 172 EP - 178 ER - TY - JOUR A1 - Scherer, Ulrich W. A1 - Srivastava, Alok A1 - Singh, Vivendra A1 - Chandra, Amita T1 - Electrical conductivity studies of swift heavy ion modified PVC and PVC-PANI composite / Alok Srivastava ,Virendra Singh, Amita Chandra, K.Witte, U.W.Scherer and T.V.Singh JF - Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 245 (2006), H. 1 Y1 - 2006 SN - 0168-583X SP - 277 EP - 280 ER - TY - JOUR A1 - Bäcker, Matthias A1 - Delle, L. A1 - Poghossian, Arshak A1 - Biselli, Manfred A1 - Zang, Werner A1 - Wagner, P. A1 - Schöning, Michael Josef T1 - Electrochemical sensor array for bioprocess monitoring JF - Electrochimica Acta (2011) Y1 - 2011 VL - 56 IS - 26 SP - 9673 EP - 9678 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Elbers, Gereon A1 - Lehmann, G. T1 - Electron Paramagnetic Resonance and Optical Absorption Spectra of VO2+ in CsCl Single Crystals JF - Zeitschrift für Naturforschung / Section A, a journal of physical sciences. 40 (1985) Y1 - 1985 SN - 0932-0784 SP - 511 ER - TY - JOUR A1 - Elbers, Gereon A1 - Lehmann, G. T1 - Electron paramagnetic resonance of Vanadyl ion impurities in crystalline solids: A comment JF - Journal of Physics and Chemistry of Solids. 46 (1985), H. 6 Y1 - 1985 SN - 0022-3697 SP - 761 ER - TY - BOOK A1 - Lauth, Jakob A1 - Goetz, Norbert A1 - Harreus, Albrecht T1 - Eljárás O-(2-hidroxi-alkil)-oximok elõállítására : [Ungarische Patentanmeldung ; Veröffentlichungsnummer HU216742 ; Veröffentlichungsdatum: 1999-08-30] / Anmelder: BASF AG. Erfinder: Gehrer Eugen ; Goetz Norbert ; Harreus Albrecht ... Guenther Lauth ... Y1 - 1999 N1 - Aktenzeichen HU19970000313 ; Nachweis unter http://hu.espacenet.com/ PB - Gehrer, Eugen CY - [Budapest] ER - TY - PAT A1 - Lauth, Jakob A1 - Gehrer, Eugen A1 - Goetz, Norbert A1 - Harreus, Albrecht T1 - Eljárás O-(2-hidroxi-alkil)-oximok elõállítására : [Ungarische Patentanmeldung ; Veröffentlichungsnummer HU77753 ; Veröffentlichungsdatum: 1998-07-28] / Anmelder: BASF AG. Erfinder: Gehrer Eugen ; Goetz Norbert ; Harreus Albrecht ... Guenther Lauth ... Y1 - 1998 N1 - Aktenzeichen HU9700313A 19950728 ; Nachweis unter http://hu.espacenet.com/ PB - [Hungarian Patent Office] CY - [Budapest] ER - TY - JOUR A1 - Cesari, Francesca A1 - Rennekampff, Verena A1 - Vintersten, Kristina A1 - Vuong, Lam Giang A1 - Seibler, Jost A1 - Bode, Jürgen A1 - Wiebel, Franziska F. A1 - Nordheim, Alfred T1 - Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange JF - Genesis : The Journal of Genetics and Development Y1 - 2004 U6 - http://dx.doi.org/10.1002/gene.20003 SN - 1526-968X VL - 38 IS - 2 SP - 87 EP - 92 ER - TY - JOUR A1 - Müller, Janina A1 - Beckers, Mario A1 - Mußmann, Nina A1 - Bongaerts, Johannes A1 - Büchs, Jochen T1 - Elucidation of auxotrophic deficiencies of Bacillus pumilus DSM 18097 to develop a defined minimal medium JF - Microbial Cell Factories N2 - Background Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is prone to significant variations from batch to batch and quality control is difficult. Therefore, the use of chemically defined media receives more and more attention in commercial fermentations. This concept results in better reproducibility, it simplifies downstream processing of secreted products and enable rapid scale-up. Culturing bacteria with unknown auxotrophies in chemically defined media is challenging and often not possible without an extensive trial-and-error approach. In this study, a respiration activity monitoring system for shake flasks and its recent version for microtiter plates were used to clarify unknown auxotrophic deficiencies in the model organism Bacillus pumilus DSM 18097. Results Bacillus pumilus DSM 18097 was unable to grow in a mineral medium without the addition of complex compounds. Therefore, a rich chemically defined minimal medium was tested containing basically all vitamins, amino acids and nucleobases, which are essential ingredients of complex components. The strain was successfully cultivated in this medium. By monitoring of the respiration activity, nutrients were supplemented to and omitted from the rich chemically defined medium in a rational way, thus enabling a systematic and fast determination of the auxotrophic deficiencies. Experiments have shown that the investigated strain requires amino acids, especially cysteine or histidine and the vitamin biotin for growth. Conclusions The introduced method allows an efficient and rapid identification of unknown auxotrophic deficiencies and can be used to develop a simple chemically defined tailor-made medium. B. pumilus DSM 18097 was chosen as a model organism to demonstrate the method. However, the method is generally suitable for a wide range of microorganisms. By combining a systematic combinatorial approach based on monitoring the respiration activity with cultivation in microtiter plates, high throughput experiments with high information content can be conducted. This approach facilitates media development, strain characterization and cultivation of fastidious microorganisms in chemically defined minimal media while simultaneously reducing the experimental effort. Y1 - 2018 U6 - http://dx.doi.org/10.1186/s12934-018-0956-1 SN - 1475-2859 VL - 17 IS - 1 SP - Article No. 106 PB - BioMed Central ER - TY - JOUR A1 - Krüger, Götz A1 - Grötzinger, Joachim A1 - Berndt, Heinz T1 - Enantiomeric resolution of amino acid derivatives on chiral stationary phases by high-performance liquid chromatography JF - Journal of Chromatography A Y1 - 1987 U6 - http://dx.doi.org/10.1016/S0021-9673(01)85005-6 SN - 0021-9673 VL - 1987 IS - 397 SP - 223 EP - 232 ER - TY - JOUR A1 - Dünnwald, Thomas A1 - Demir, Ayhan S. A1 - Siegert, Petra A1 - Pohl, Martina A1 - Müller, Michael T1 - Enantioselective Synthesis of (S)-2-Hydroxypropanone Derivatives by Benzoylformate Decarboxylase Catalyzed C−C Bond Formation JF - European journal of organic chemistry Y1 - 2000 SN - 0365-5490 (E-Journal); 1099-0690 (E-Journal); 0075-4617 (Print); 0170-2041 (Print); 0947-3440 (Print); 1434-193X (Print); 1434-243X (Print) VL - Vol. 2000 IS - Iss. 11 SP - 2161 EP - 2170 ER - TY - THES A1 - Maintz, Stephan T1 - Enantioselektive Reduktion prochiraler Carbonylverbindungen mit Chiralidon R & S in einem kontinuierlich betriebenen Festbettreaktor Y1 - 2014 ER - TY - RPRT A1 - Vaeßen, Christiane A1 - Ohme, H. A1 - Manderscheid, D. T1 - Endbericht Projekt Immotherm : Vorhabensbezeichnung: KMU-innovativ-Verbundvorhaben "Einsatz immobilisierter Mikroorganismen zur Entölung und Entsalzung von Kondensatwasser bei hohen Prozesstemperaturen" : Laufzeit des Vorhabens: 01.03.2009-31.08.2011 : Förderkennzeichen: 01LY0816A, 01LY0816B, 01LY0816C Y1 - 2012 ER - TY - JOUR A1 - Feuerriegel, Uwe T1 - Energetische Verwertung von Kunststoffabfällen JF - Chemie und Technologie makromolekularer Stoffe :, 16. Kolloquium. / Fachhochschule / Fachbereich Chemieingenieurwesen. 20. November 1998 an der FH Aachen, Fachbereich Chemieingenieurwesen Y1 - 1998 N1 - FH-Texte. 69; In Jülich unter der Signatur: 61 ZOW 405-16 SP - 169 EP - 189 PB - Fachhochschule Aachen CY - Aachen ER - TY - JOUR A1 - Manea, Marilena A1 - Leurs, Ulrike A1 - Orban, Erika A1 - Baranyai, Zsuzsa A1 - Öhlschläger, Peter A1 - Marquardt, Andreas A1 - Schulcz, Akos A1 - Tejeda, Miguel T1 - Enhanced Enzymatic Stability and Antitumor Activity of Daunorubicin-GnRH-III Bioconjugates Modified in Position 4 JF - Bioconjugate Chemistry Y1 - 2011 SN - 1520-4812 VL - 22 IS - 7 SP - 1320 EP - 1329 PB - ACS CY - Washington, DC ER - TY - JOUR A1 - Gerigk, M. A1 - Maaß, D. A1 - Kreutzer, A. A1 - Sprenger, G. A1 - Bongaerts, Johannes A1 - Wubbolts, Marcel A1 - Takors, Ralf T1 - Enhanced pilot-scale fed-batch L-phenylalanine production with recombinant Escherichia coli by fully integrated reactive extraction JF - Bioprocess and biosystems engineering Y1 - 2002 SN - 1432-0797 (E-Journal); 1615-7605 (E-Journal); 0178-515X (Print); 1615-7591 (Print) VL - Vol. 25 IS - Iss. 1 SP - 43 EP - 52 ER - TY - JOUR A1 - Plum, Leona A1 - Ma, Xiaosong A1 - Hampel, Brigitte A1 - Balthasar, Nina A1 - Coppari, Roberto A1 - Münzberg, Heike A1 - Shanabrough, Marya A1 - Burdakov, Denis A1 - Rother, Eva A1 - Janoschek, Ruth A1 - Alber, Jens A1 - Belgardt, Bengt F. A1 - Koch, Linda A1 - Seibler, Jost A1 - Schenk, Frieder A1 - Fekete, Csaba A1 - Suzuki, Akira A1 - Mak, Tak W. A1 - Krone, Wilhelm A1 - Horvath, Tamas L. A1 - Ashcroft, Frances M. A1 - Brüning, Jens C. T1 - Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity JF - The Journal of Clinical Investigation (JCI) Y1 - 2006 U6 - http://dx.doi.org/10.1172/JCI27123 SN - 1558-8238 VL - 116 IS - 7 SP - 1886 EP - 1901 ER - TY - JOUR A1 - Öhlschläger, Peter A1 - Quetting, Michael A1 - Alvarez, Gerardo A1 - Dürst, Matthias A1 - Gissmann, Lutz A1 - Kaufmann, Andreas M. T1 - Enhancement of immunogenicity of a therapeutic cervical cancer DNA-based vaccine by co-application of sequence-optimized genetic adjuvants JF - International Journal of Cancer Y1 - 2009 SN - 1097-0215 VL - 125 IS - 1 SP - 189 EP - 198 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Kotter, Michael A1 - Riekert, Lothar A1 - Turek, Thomas T1 - Entfernung von Ammoniak aus Abwässern durch Strippung und Sorption an Zeolithen : [Synopse 1724] JF - Chemie - Ingenieur - Technik. 61 (1989), H. 1 Y1 - 1989 SN - 0009-286X N1 - ISSN der E-Ausg.: 1522-2640; Das vollständige Manuskript dieser Arbeit umfasst 45 Seiten. Es ist [lt. Verl.] als Fotokopie oder Mikrofiche MS 1724/88 erhältlich. SP - 74 EP - 75 ER - TY - JOUR A1 - Mang, Thomas A1 - Haulena, Friedhelm A1 - Brill, B. T1 - Entsorgung beflockter Verbundwerkstoffe JF - Flock 97 : 14. Internationales Flockseminar Seeheim bei Darmstadt 16. - 17. Januar 1997. Y1 - 1997 N1 - International Flock Symposium <14, 1997, Seeheim> SP - 10-1 EP - 10-18 PB - Flock-Verl. CY - Büdingen ER - TY - JOUR A1 - Biselli, Manfred A1 - Bäcker, Matthias A1 - Poghossian, Arshak A1 - Schöning, Michael Josef A1 - Schnitzler, Thomas A1 - Zang, Werner A1 - Wagner, P. T1 - Entwicklung eines modularen festkörperbasierten Sensorsystems für die Überwachung von Zellkulturfermenationen JF - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA) Y1 - 2010 SN - 978-3-8007-3260-9 N1 - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik SP - 688 EP - 691 PB - VDE Verlag CY - Berlin ER - TY - BOOK A1 - Elbers, Gereon T1 - Entwicklung eines Schnellmessverfahrens zur Charakterisierung der Wirkung von Umweltschadstoffen auf Pflanzen mit der Nahinfrarot-Spektroskopie : Schlussbericht zum Forschungsvorhaben ; Vorhabensbezeichnung: Schnellmessverfahren zur Charakterisierung der Wirkung von Umweltschadstoffen ; Laufzeit des Vorhabens: 01.09.2002 bis 29.02.2004 ; Verlängerung der Laufzeit: 01.03.2004 bis 30.04.04 ; Berichtszeitraum: 01.09.2002 bis 30.04.2004 / Zuwendungsempfänger: FH-Aachen, Abt. Jülich, FB Chemie und Biotechnik. Gereon Elbers Y1 - 2004 N1 - Förderkennzeichen BMBF 1704502 ; weitere elektr. Ausgabe der TIB Hannover : http://edok01.tib.uni-hannover.de/edoks/e01fb05/485188317.pdf PB - Fachhochschule Aachen CY - Jülich ER - TY - BOOK A1 - Kotter, Michael A1 - Lintz, Hans-Günther A1 - Turek, Thomas T1 - Entwicklung eines SCR-Katalysators für instationäre Reaktionsführung. - (Forschungsbericht KfK-PEF ; 79) Y1 - 1991 N1 - ISSN der Serie: 0931-2749 ; Zsfassungen in dt. und engl. Sprache PB - Kernforschungszentrum CY - Karlsruhe ER - TY - JOUR A1 - Deppe, Veronika Maria A1 - Bongaerts, Johannes A1 - O'Connell, Timothy A1 - Maurer, Karl-Heinz A1 - Meinhardt, Friedhelm T1 - Enzymatic deglycation of Amadori products in bacteria JF - Applied microbiology and biotechnology Y1 - 2011 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 90 IS - Iss. 2 SP - 399 EP - 406 PB - Springer CY - Berlin ER - TY - JOUR A1 - Tippkötter, Nils A1 - Duwe, Anna-Maria A1 - Wiesen, Sebastian A1 - Sieker, Tim A1 - Ulber, Roland T1 - Enzymatic hydrolysis of beech wood lignocellulose at high solid contents and its utilization as substrate for the production of biobutanol and dicarboxylic acids JF - Bioresource Technology N2 - The development of a cost-effective hydrolysis for crude cellulose is an essential part of biorefinery developments. To establish such high solid hydrolysis, a new solid state reactor with static mixing is used. However, concentrations >10% (w/w) cause a rate and yield reduction of enzymatic hydrolysis. By optimizing the synergetic activity of cellulolytic enzymes at solid concentrations of 9%, 17% and 23% (w/w) of crude Organosolv cellulose, glucose concentrations of 57, 113 and 152 g L⁻¹ are reached. However, the glucose yield decreases from 0.81 to 0.72gg⁻¹ at 17% (w/w). Optimal conditions for hydrolysis scale-up under minimal enzyme addition are identified. As result, at 23% (w/w) crude cellulose the glucose yield increases from 0.29 to 0.49gg⁻¹. As proof of its applicability, biobutanol, succinic and itaconic acid are produced with the crude hydrolysate. The potential of the substrate is proven e.g. by a high butanol yield of 0.33gg⁻¹. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.biortech.2014.06.052 VL - 167 SP - 447 EP - 455 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Capitain, C. A1 - Hering, T. A1 - Tippkötter, Nils A1 - Ulber, R. T1 - Enzymatic polymerization of lignin model compounds and solubilized lignin in an aqueous ethanol extract T2 - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany Y1 - 2016 SP - 151 EP - 152 PB - DECHEMA CY - Frankfurt am Main ER - TY - JOUR A1 - Jeromin, Günter Erich A1 - Weise, Sven T1 - Enzymatische Acetylierung von (±)-1-Phthalimido-2-propanol JF - Liebigs Annalen der Chemie (1990) Y1 - 1990 SN - 0947-3440 N1 - ISSN der E-Ausg.: 1099-0690 SP - 1045 EP - 1046 ER - TY - JOUR A1 - Niehaus, F. A1 - Gabor, E. A1 - Wieland, S. A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Eck, J. T1 - Enzymes for the laundry industries: tapping the vast metagenomic pool of alkaline proteases JF - Microbial biotechnology Y1 - 2011 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 4 IS - Iss. 6 SP - 767 EP - 776 PB - Springer CY - Berlin ER - TY - PAT A1 - Jeromin, Günter Erich T1 - Enzymkatalysierte irreversible Veresterung von Carbonsäuren in organischem Lösungsmittel : Offenlegungsschrift DE102005061737A1 ; Offenlegungstag: 05.07.2007 Y1 - 2007 N1 - Volltext über Datenbank: http://publikationen.dpma.de/ PB - Deutsches Patent- und Markenamt CY - München ER - TY - BOOK A1 - Biselli, Manfred T1 - Enzymkatalysierte Racematspaltung von Aminosäuren mit integrierter Rückführung : dargestellt am Beispiel der Umsetzung von D,L-Alanin zu L-Alanin / Manfred Fridolin Biselli Y1 - 1992 N1 - Berichte des Forschungszentrums Jülich ; 2581 PB - Forschungszentrum Jülich, Zentralbibliothek CY - Jülich ER - TY - BOOK A1 - Biselli, Manfred T1 - Enzymkatalysierte Racematspaltung von Aminosäuren mit integrierter Rückführung : dargestellt am Beispiel der Umsetzung von D,L-Alanin zu L-Alanin / vorgelegt von Manfred Fridolin Biselli Y1 - 1992 N1 - Bonn, Univ., Diss., 1991 CY - Bonn ER - TY - JOUR A1 - Elbers, Gereon A1 - Remme, S. A1 - Lehmann, G. T1 - EPR and Optical Absorption of Cr3+ in CsCl and CsBr JF - Physica Status Solidi (B). 142 (1987), H. 2 Y1 - 1987 SN - 0031-8957 SP - 367 EP - 377 ER - TY - JOUR A1 - Elbers, Gereon A1 - Remme, S. A1 - Lehmann, G. T1 - EPR of Cr3+ in Tris(acetylacetonato)gallium(III) Single Crystals JF - Inorganic Chemistry. 25 (1986) Y1 - 1986 SN - 0020-1669 SP - 896 EP - 897 ER - TY - JOUR A1 - Sieker, Tim A1 - Neuner, Andreas A1 - Dimitrova, Darina A1 - Tippkötter, Nils A1 - Muffler, Kai A1 - Bart, Hans-Jörg A1 - Heinzle, Elmar A1 - Ulber, Roland T1 - Ethanol production from grass silage by simultaneous pretreatment, saccharification and fermentation: First steps in the process development JF - Engineering in Life Sciences N2 - Grass silage provides a great potential as renewable feedstock. Two fractions of the grass silage, a press juice and the fiber fraction, were evaluated for their possible use for bioethanol production. Direct production of ethanol from press juice is not possible due to high concentrations of organic acids. For the fiber fraction, alkaline peroxide or enzymatic pretreatment was used, which removes the phenolic acids in the cell wall. In this study, we demonstrate the possibility to integrate the enzymatic pretreatment with a simultaneous saccharification and fermentation to achieve ethanol production from grass silage in a one-process step. Achieved yields were about 53 g ethanol per kg silage with the alkaline peroxide pretreatment and 91 g/kg with the enzymatic pretreatment at concentrations of 8.5 and 14.6 g/L, respectively. Furthermore, it was shown that additional supplementation of the fermentation medium with vitamins, trace elements and nutrient salts is not necessary when the press juice is directly used in the fermentation step. Y1 - 2011 U6 - http://dx.doi.org/10.1002/elsc.201000160 N1 - Special Issue "Bioprocess‐oriented plant design" VL - 11 IS - 4 SP - 436 EP - 442 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Roth, Jasmine A1 - Tippkötter, Nils T1 - Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium JF - Cellulose Chemistry and Technology N2 - Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹. Y1 - 2016 VL - 50 IS - 3-4 SP - 405 EP - 410 PB - Editura Academiei Romane CY - Bukarest ER - TY - JOUR A1 - Salpati, Laurent A1 - Chu, Xiaoyan A1 - Chen, Liangfu A1 - Prasad, Bhagwat A1 - Dallas, Shannon A1 - Evers, Raymond A1 - Mamaril-Fishman, Donna A1 - Geier, Ethan G. A1 - Kehler, Jonathan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Soars, Matthew G. A1 - Unadkat, Jashvant D. A1 - van Waterschoot, Robert A.B. A1 - Yabut, Jocelyn A1 - Schinkel, Alfred H. A1 - Scheer, Nico A1 - Rode, Anja T1 - Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins JF - Drug Metabolism and Disposition N2 - Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography–tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans. Y1 - 2014 U6 - http://dx.doi.org/10.1124/dmd.114.057976 SN - 1521-009X VL - 42 IS - 8 SP - 1301 EP - 1313 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Eckert, Alexander A1 - Rudolph, Tobias A1 - Guo, Jiaqi A1 - Mang, Thomas A1 - Walther, Andreas T1 - Exceptionally Ductile and Tough Biomimetic Artificial Nacre with Gas Barrier Function JF - Advanced Materials N2 - Synthetic mimics of natural high-performance structural materials have shown great and partly unforeseen opportunities for the design of multifunctional materials. For nacre-mimetic nanocomposites, it has remained extraordinarily challenging to make ductile materials with high stretchability at high fractions of reinforcements, which is however of crucial importance for flexible barrier materials. Here, highly ductile and tough nacre-mimetic nanocomposites are presented, by implementing weak, but many hydrogen bonds in a ternary nacre-mimetic system consisting of two polymers (poly(vinyl amine) and poly(vinyl alcohol)) and natural nanoclay (montmorillonite) to provide efficient energy dissipation and slippage at high nanoclay content (50 wt%). Tailored interactions enable exceptional combinations of ductility (close to 50% strain) and toughness (up to 27.5 MJ m⁻³). Extensive stress whitening, a clear sign of high internal dynamics at high internal cohesion, can be observed during mechanical deformation, and the materials can be folded like paper into origami planes without fracture. Overall, the new levels of ductility and toughness are unprecedented in highly reinforced bioinspired nanocomposites and are of critical importance to future applications, e.g., as barrier materials needed for encapsulation and as a printing substrate for flexible organic electronics. Y1 - 2018 U6 - http://dx.doi.org/10.1002/adma.201802477 VL - 30 IS - 32 SP - Article number 1802477 PB - Wiley-VCH ER - TY - JOUR A1 - Siegert, Petra A1 - McLeish, Michael J. A1 - Baumann, Martin A1 - Iding, Hans A1 - Kneen, Malea M. A1 - Kenyon, George L. A1 - Pohl, Martina T1 - Exchanging the substrate specificities of pyruvate decarboxylase from Zymomonas mobilis and benzoylformate decarboxylase from Pseudomonas putida JF - Protein engineering, design, and selection : peds Y1 - 2005 SN - 1460-213X (E-Journal); 1741-0134 (E-Journal); 0269-2139 (Print); 1741-0126 (Print) VL - Vol. 18 IS - Iss. 7 SP - 345 EP - 357 ER -