TY  - JOUR
A1  - Bäcker, Matthias
A1  - Raue, Markus
A1  - Schusser, Sebastian
A1  - Jeitner, C.
A1  - Breuer, L.
A1  - Wagner, P.
A1  - Poghossian, Arshak
A1  - Förster, Arnold
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
T1  - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films
JF  - Physica Status Solidi  (a)
N2  - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.
Y1  - 2012
U6  - http://dx.doi.org/10.1002/pssa.201100763
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 839
EP  - 845
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - PAT
A1  - Berg, Gabriele
A1  - Bessler, Cornelius
A1  - Gerlach, Jochen
A1  - Gübitz, Georg
A1  - Heumann, Sonja
A1  - Karl, Wolfgang
A1  - Maurer, Karl-Heinz
A1  - Remler, Peter
A1  - Ribitsch, Doris
A1  - Schwab, Helmut
A1  - Siegert, Petra
A1  - Wieland, Susanne
T1  - Mittel enthaltend Proteasen aus Stenotrophomonas maltophilia [Offenlegungsschrift]
T1  - Agents containing proteases from Stenotrophomonas maltophilia [Europäische Patentanmeldung / US Patentanmeldung / Internationale Patentanmeldung]
Y1  - 2009
SP  - 1
EP  - 47
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt / USPTO / WIPO
CY  - München / Den Hague / Washington / Genf
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - http://dx.doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Kricheldorf, Hans R.
A1  - Au, M.
T1  - Models of molecular evolution. 2. Stereospecificity of dipeptide syntheses by means of cyanamides and carbodiimides / Kricheldorf, Hans R. ; Au, M. ; Mang, Thomas
JF  - International journal of peptide and protein research. 26 (1985), H. 2
Y1  - 1985
SN  - 0300-9769
SP  - 149
EP  - 157
ER  - 
TY  - JOUR
A1  - Öhlschläger, Peter
A1  - Steinberg, Thorsten
A1  - Sehr, Peter
A1  - Osen, Wolfram
T1  - Modification of HPV 16 E7 genes: correlation between the level of protein expression and CTL response after immunization of C57BL/6 mice / Steinberg, Thorsten ; Öhlschläger, Peter ; Sehr, Peter ; Osen, Wolfram ; Gissmann, Lutz
JF  - Vaccine. 23 (2005), H. 9
Y1  - 2005
SN  - 0264-410X
SP  - 1149
EP  - 1157
ER  - 
TY  - JOUR
A1  - Werkhausen, Amelie
A1  - Albracht, Kirsten
A1  - Cronin, Neil J.
A1  - Meier, Rahel
A1  - Mojsen-Moeller, Jens
A1  - Seynnes, Olivier R.
T1  - Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task
JF  - Journal of Experimental Biology
Y1  - 2017
U6  - http://dx.doi.org/10.1242/jeb.164111
SN  - 0022-0949
VL  - 220
IS  - 22
SP  - 4141
EP  - 4149
ER  - 
TY  - BOOK
A1  - Baüer, Herbert
A1  - Gilch, Heinz Gerhard
A1  - Rath, Walter
A1  - Schümann, Uwe
T1  - Moisture-curing polyurethane-based hot-melt compositions = Feuchthärtbare Heisschmelz-Zusammensetzungen auf Polyurethanbasis
Y1  - 1990
N1  - EP0386879 18.10.1990 Veröffentlichungstag im Patentblatt  ; Volltext recherchierbar über
PB  - Europäisches Patentamt
CY  - München
ER  - 
TY  - BOOK
A1  - Gilch, Heinz Gerhard
A1  - Rath, Walter
T1  - Moisture-curing, polyurethane hot-melt compositions = Feuchtigkeitshärtende Polyurethan-Schmelzklebstoff-Zusammensetzungen
Y1  - 1995
N1  - EP 0369607 30.03.1995 Veröffentlichungstag im Patentblatt ; Volltext recherchierbar über:
PB  - Europäisches Patentamt
CY  - München
ER  - 
TY  - CHAP
A1  - Medlin, L. K.
A1  - Barker, G. L. A.
A1  - Baumann, Marcus
A1  - Hayes, P. K.
T1  - Molecular biology and systematics
T2  - The Haptophyte Algae (Special volume / Systematics Association : 51)
Y1  - 1994
SN  - 0-19-857772-9
SP  - 393
EP  - 411
PB  - Clarendon Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Dutta, Suryendu
A1  - Hartkopf-Fröder, Christoph
A1  - Witte, Karin
A1  - Brocke, Rainer
A1  - Mann, Ulrich
T1  - Molecular characterization of fossil palynomorphs by transmission micro-FTIR spectroscopy: implications for hydrocarbon source evaluation
JF  - International journal of coal geology
Y1  - 2013
SN  - 1872-7840 (E-Journal); 0166-5162 (Print)
VL  - Vol. 115
SP  - 13
EP  - 23
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hentschke, Reinhard
A1  - Hager, Jonathan
A1  - Hojdis, Nils
T1  - Molecular Modeling Approach to the Prediction of Mechanical Properties of Silica-Reinforced Rubbers
JF  - Journal of Applied Polymer Science
N2  - Recently, we have suggested a nanomechanical model for dissipative loss in filled elastomer networks in the context of the Payne effect. The mechanism is based on a total interfiller particle force exhibiting an intermittent loop, due to the combination of short-range repulsion and dispersion forces with a long-range elastic attraction. The sum of these forces leads, under external strain, to a spontaneous instability of “bonds” between the aggregates in a filler network and attendant energy dissipation. Here, we use molecular dynamics simulations to obtain chemically realistic forces between surface modified silica particles. The latter are combined with the above model to estimate the loss modulus and the low strain storage modulus in elastomers containing the aforementioned filler-compatibilizer systems. The model is compared to experimental dynamic moduli of silica filled rubbers. We find good agreement between the model predictions and the experiments as function of the compatibilizer's molecular structure and its bulk concentration.
KW  - theory and modeling
KW  - supramolecular structures
KW  - rubber
KW  - mechanical properties
KW  - elastomers
Y1  - 2014
U6  - http://dx.doi.org/10.1002/app.40806
SN  - 1097-4628
VL  - 131
IS  - 18
SP  - 1
EP  - 9
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Lauth, Jakob
A1  - Hoelderich, W.
A1  - Wagenblast, G.
T1  - Molecular sieves containing azo dyes
JF  - Zeolites. 15 (1995), H. 2
Y1  - 1995
SN  - 0144-2449
SP  - 184
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molecular sieves containing azo dyes : United States Patent ; patent number 5,573,585 ; date of patent: Nov. 12, 1996 / assignee: Wolfgang Hoelderich. Inventors: Guenter Lauth ; Wolfgang Hoelderich ; Gerhard Wagenblast ...
Y1  - 1996
N1  - Barcode: US005573585A ; Volltext über Datenbank: http://www.google.com/patents
PB  - [United States Trademark and Patent Office]
CY  - [Alexandria, VA]
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molecular sieves containing azo dyes ; Internationale [Pantent]anmeldung WO93/17965 ; Veröffentlichungsdatum: 16.09.1993  / Anmelder: BASF AG
Y1  - 1993
N1  - Volltext über Datenbank http://depatisnet.dpma.de/
PB  - Weltorganisation für geistiges Eigentum, Internat. Büro
CY  - [Genf]
ER  - 
TY  - JOUR
A1  - Meyer, Jan
A1  - Hentschke, Reinhard
A1  - Hager, Jonathan
A1  - Hojdis, Nils
A1  - Karimi-Varzaneh, Hossein Ali
T1  - Molecular Simulation of Viscous Dissipation due to Cyclic Deformation of a Silica–Silica Contact in Filled Rubber
JF  - Macromolecules
Y1  - 2017
U6  - http://dx.doi.org/10.1021/acs.macromol.7b00947
SN  - 1520-5835
VL  - 50
IS  - 17
SP  - 6679
EP  - 6689
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Hölderich, Wolfgang
A1  - Wagenblast, Gerhard
A1  - Schefczik, Ernst
T1  - Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo : Offenlegungsschrift DE4207339A1 ; Veröffentlichungstag im Patentblatt: 16.09.1993 / Anmelder: BASF AG, 67063 Ludwigshafen
Y1  - 1993
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo = Molecular sieves containing indigo-based dyes ; Europäische Patenanmeldung EP0630353A1 ; Veröffentlichungsdatum 28.12.1994 / Anmelder: BASF AG
Y1  - 1994
N1  - Internationale Anmeldung veröffentlicht durch die Weltorganisation für geistiges Eigentum unter der Nummer WO 93/17966
PB  - Europäisches Patentamt
CY  - [München u.a.]
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Hoelderich, Wolfgang
A1  - Wagenblast, Gerhard
T1  - Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo = Molecular sieves containing indigo-based dyes ; Internationale [Pantent]anmeldung WO 93/17966 ; Veröffentlichungsdatum 16.09.1993 / Anmelder: BASF AG
Y1  - 1993
N1  - Volltext über Datenbank http://depatisnet.dpma.de/
PB  - Weltorganisation für geistiges Eigentum, Internat. Büro
CY  - [Genf]
ER  - 
TY  - JOUR
A1  - Mang, Thomas
A1  - Haulena, Friedhelm
T1  - Monodisperse latex particles with functional groups
JF  - Modification of polymers : 4th Dresden Polymer Discussion ; September 22 to 25, 1992 at Gaussig / Dresden University of Technology, Department of Macromolecular Chemistry and Textile Chemistry; Institute of Polymer Technology Dresden. [Organizers: Claudia Kummerlöwe ...]
Y1  - 1992
N1  - Dresdner Polymer Discussion <4, 1992, Gaußig>
SP  - 68
EP  - 88
PB  - Univ.
CY  - Dresden
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
T1  - Monomodal and polymodal catalyst supports and catalysts having narrow pore size distributions and their production : United States Patent ; patent number 5,935,898 ; date of patent: Aug. 10, 1999 / assignee: BASF Aktiengesellschaft. Inventors: Peter Trubenbach ; Alfred Hagemeyer ; Gunter Lauth ...
Y1  - 1999
N1  - Barcode: US005935898A ; Volltext über Datenbank: http://www.google.com/patents ; Falsche Namensansetzung in Datenbank: Gunter ...
PB  - [United States Patent and Trademark Office]
CY  - [Alexandria, VA]
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
T1  - Monomodale und polymodale Katalysatorträger und Katalysatoren mit engen Porengrössenverteilungen und deren Herstellverfahren : Europäische Patentschrift EP0764467B1 ; EP-Patenterteilungsdatum: 05.02.2003 / Anmelder: BASF AG, 67063 Ludwigshafen. Erfinder: Peter Trübenbach ; Alfred Hagemeyer ; Günter Lauth ...
Y1  - 2003
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Europäisches Patentamt
CY  - [München u.a.]
ER  - 
TY  - PAT
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
A1  - Dingerdissen, Uwe [u.a.]
T1  - Monomodale und polymodale Katalysatorträger und Katalysatoren mit engen Porengrößenverteilungen und deren Herstellverfahren : Offenlegungschrift DE19533486A1 ; Veröffentlichungstag im Patentblatt: 13.03.1997 / Anmelder: BASF AG, 67063 Ludwigshafen. Erfinder: Peter Trübenbach ; Alfred Hagemeyer ; Günter Lauth ...
Y1  - 1997
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - BOOK
A1  - Lauth, Jakob
A1  - Trübenbach, Peter
A1  - Hagemeyer, Alfred
T1  - Monomodale und polymodale Katalysatorträger und Katalysatoren mit engen Porengrößenverteilungen und deren Herstellverfahren = Monomodal and polymodal catalyst supports and catalysts with a narrow pore size distribution and method for producing the same ; Europäische Patentschrift EP0761307B1 ; Veröffentlichungsdatum 05.02.2003  / Anmelder: BASF Aktiengesellschaft. Erfinder: Peter Trübenbach ; Alfred Hagemeyer ; Günther Lauth ...
Y1  - 2003
N1  - Volltext über Datenbank http://publikationen.dpma.de/ ; Falsche Namenansersetzung in Datenbank: Günther
PB  - Europäisches Patentamt
CY  - [München u.a.]
ER  - 
TY  - JOUR
A1  - Adels, Klaudia
A1  - Elbers, Gereon
A1  - Diehl, Bernd
A1  - Monakhova, Yulia
T1  - Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study
JF  - Analytical Sciences
N2  - With the prevalence of glucosamine- and chondroitin-containing dietary supplements for people with osteoarthritis in the marketplace, it is important to have an accurate and reproducible analytical method for the quantitation of these compounds in finished products. NMR spectroscopic method based both on low- (80 MHz) and high- (500–600 MHz) field NMR instrumentation was established, compared and validated for the determination of chondroitin sulfate and glucosamine in dietary supplements. The proposed method was applied for analysis of 20 different dietary supplements. In the majority of cases, quantification results obtained on the low-field NMR spectrometer are similar to those obtained with high-field 500–600 MHz NMR devices. Validation results in terms of accuracy, precision, reproducibility, limit of detection and recovery demonstrated that the developed method is fit for purpose for the marketed products. The NMR method was extended to the analysis of methylsulfonylmethane, adulterant maltodextrin, acetate and inorganic ions. Low-field NMR can be a quicker and cheaper alternative to more expensive high-field NMR measurements for quality control of the investigated dietary supplements. High-field NMR instrumentation can be more favorable for samples with complex composition due to better resolution, simultaneously giving the possibility of analysis of inorganic species such as potassium and chloride.
KW  - Glucosamine
KW  - Chondroitin sulfate
KW  - Polysaccharides
KW  - Dietary supplements
KW  - High-field NMR
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s44211-023-00433-2
SN  - 1348-2246 (Online)
SN  - 0910-6340 (Print)
N1  - Corresponding author: Yulia Monakhova
VL  - 2023
PB  - Springer Verlag
CY  - Cham
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.K.
T1  - Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent
JF  - Journal of Pharmaceutical and Biomedical Analysis
N2  - NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.
KW  - NMR spectroscopy
KW  - Inorganic ions
KW  - Heparin
KW  - Standardization
Y1  - 2022
SN  - 0731-7085
U6  - http://dx.doi.org/10.1016/j.jpba.2021.114530
VL  - 209
IS  - Article number: 114530
PB  - Elsevier
ER  - 
TY  - JOUR
A1  - Prielmeier, Franz
A1  - Lang, E. W.
T1  - Multinuclear Spin-Lattice Relaxation Time Studies of Supercooled Aqueous LiCl-Solutions / E .W. Lang, F. X. Prielmeier
JF  - Berichte der Bunsen-Gesellschaft für Physikalische Chemie. 92 (1988)
Y1  - 1988
SN  - 0005-9021
SP  - 717
ER  - 
TY  - JOUR
A1  - Svaneborg, Carsten
A1  - Karimi-Varzaneh, Hossein Ali
A1  - Hojdis, Nils
A1  - Fleck, Franz
A1  - Everaers, Ralf
T1  - Multiscale approach to equilibrating model polymer melts
JF  - Physical Review E
N2  - We present an effective and simple multiscale method for equilibrating Kremer Grest model polymer melts of varying stiffness. In our approach, we progressively equilibrate the melt structure above the tube scale, inside the tube and finally at the monomeric scale. We make use of models designed to be computationally effective at each scale. Density fluctuations in the melt structure above the tube scale are minimized through a Monte Carlo simulated annealing of a lattice polymer model. Subsequently the melt structure below the tube scale is equilibrated via the Rouse dynamics of a force-capped Kremer-Grest model that allows chains to partially interpenetrate. Finally the Kremer-Grest force field is introduced to freeze the topological state and enforce correct monomer packing. We generate 15 melts of 500 chains of 10.000 beads for varying chain stiffness as well as a number of melts with 1.000 chains of 15.000 monomers. To validate the equilibration process we study the time evolution of bulk, collective, and single-chain observables at the monomeric, mesoscopic, and macroscopic length scales. Extension of the present method to longer, branched, or polydisperse chains, and/or larger system sizes is straightforward.
Y1  - 2016
U6  - http://dx.doi.org/10.1103/PhysRevE.94.032502
SN  - 2470-0053
VL  - 94
IS  - 032502
PB  - AIP Publishing
CY  - Melville, NY
ER  - 
TY  - JOUR
A1  - Baumann, Marcus
A1  - Gronsfeld, A.
A1  - Schütz-Lembach, G.
T1  - Nachdenklichkeit über Nachhaltigkeit : wie uns ein neues Wort alte Probleme neu entdecken läßt
JF  - Wechselwirkung : Wissenschaft & vernetztes Denken
Y1  - 1997
SN  - 0172-1623
VL  - 19
IS  - 87
SP  - 6
EP  - 11
ER  - 
TY  - BOOK
A1  - Selmer, Thorsten
T1  - Nachweis einer neuartigen posttranslationalen Modifikation in Sulfatasen und ihr Fehlen in Enzymen aus Patienten mit multipler Sulfatase-Defizienz
Y1  - 1996
N1  - Zugl.: Göttingen, Univ., Diss., 1996
PB  - Cuvillier
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Druckenmüller, Katharina
A1  - Günther, Klaus
A1  - Elbers, Gereon
T1  - Near-infrared spectroscopy (NIRS) as a tool to monitor exhaust air from poultry operations
JF  - Science of the Total Environment
N2  - Intensive poultry operation systems emit a considerable volume of inorganic and organic matter in the surrounding environment. Monitoring cleaning properties of exhaust air cleaning systems and to detect small but significant changes in emission characteristics during a fattening cycle is important for both emission and fattening process control. In the present study, we evaluated the potential of near-infrared spectroscopy (NIRS) combined with chemometric techniques as a monitoring tool of exhaust air from poultry operation systems. To generate a high-quality data set for evaluation, the exhaust air of two poultry houses was sampled by applying state-of-the-art filter sampling protocols. The two stables were identical except for one crucial difference, the presence or absence of an exhaust air cleaning system. In total, twenty-one exhaust air samples were collected at the two sites to monitor spectral differences caused by the cleaning device, and to follow changes in exhaust air characteristics during a fattening period. The total dust load was analyzed by gravimetric determination and included as a response variable in multivariate data analysis. The filter samples were directly measured with NIR spectroscopy. Principal component analysis (PCA), linear discriminant analysis (LDA), and factor analysis (FA) were effective in classifying the NIR exhaust air spectra according to fattening day and origin. The results indicate that the dust load and the composition of exhaust air (inorganic or organic matter) substantially influence the NIR spectral patterns. In conclusion, NIR spectroscopy as a tool is a promising and very rapid way to detect differences between exhaust air samples based on still not clearly defined circumstances triggered during a fattening period and the availability of an exhaust air cleaning system.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.scitotenv.2018.02.072
SN  - 0048-9697
VL  - 630
SP  - 536
EP  - 543
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Wieland, Susanne
A1  - Engelskirchen, Julia
A1  - Merkel, Marion
A1  - Maurer, Karl-Heinz
A1  - Bessler, Cornelius
T1  - Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease [Offenlegungsschrift]
T1  - Novel alkaline protease from Bacillus Gibsonii and washing and cleaning agents containing said novel alkaline protease [Europäische Patentanmeldung / US Patentanmeldung / Internationale Patentanmeldung]
Y1  - 2008
SP  - 1
EP  - 51
PB  - Deutsches Patentamt / Europäisches Patentamt / WIPO
CY  - München / Den Hague / Genf
ER  - 
TY  - PAT
A1  - Merkel, Marion
A1  - Weber, Angrit
A1  - Siegert, Petra
A1  - Wieland, Susanne
A1  - Maurer, Karl-Heinz
A1  - Bessler, Cornelius
T1  - Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease [Offenlegungsschrift]
T1  - Novel alkaline protease from Bacillus Gibsonii and washing and cleaning agents containing said novel alkaline protease [Internationale Patentanmeldung]
Y1  - 2007
SP  - 1
EP  - 46
PB  - Deutsches Patent- und Markenamt / WIPO
CY  - München / Genf
ER  - 
TY  - JOUR
A1  - Biselli, Manfred
A1  - Jelinek, N.
A1  - Schmidt, S.
A1  - Hilbert, U.
T1  - Neue Bioreaktoren zur Kultivierung hämatopoetischer Zellen / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C.
JF  - Chemie Ingenieur Technik. 73 (2001), H. 7
Y1  - 2001
SN  - 0009-286X
SP  - 894
EP  - 898
ER  - 
TY  - BOOK
A1  - Berndt, Heinz
T1  - Neue Kondensations-Methoden zur Synthese definierter Peptid-Derivate
Y1  - 2014
N1  - Aachen, Techn. Hochsch., Habil.-Schr., 1982
CY  - Aachen
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Merkel, Marion
A1  - Kluin, Cornelia
A1  - Maurer, Karl-Heinz
A1  - O'Connell, Timothy
A1  - Wieland, Susanne
A1  - Hellmuth, Hendrik
T1  - Neue Proteasen und diese enthaltende Mittel [Offenlegungsschrift]
T1  - Novel proteases and compositions comprising them [Europäische Patentanmeldung / Internationale Patentanmeldung]
Y1  - 2011
SP  - 1
EP  - 21
PB  - Deutsches Patent- und Markenamt / Europäisches Patentamt / WIPO
CY  - München / Den Hague / Genf
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Mussmann, Nina
A1  - O'Connell, Timothy
A1  - Maurer, Karl-Heinz
T1  - Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]
T1  - Novel proteases and means containing said proteases [Internationale Patentanmeldung]
Y1  - 2010
SP  - 1
EP  - 30
PB  - Deutsches Patent- und Markenamt / WIPO
CY  - München / Genf
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Baumstark, Rebecca
A1  - Kluin, Cornelia
A1  - O'Connell, Timothy
A1  - Maurer, Karl-Heinz
A1  - Hellmuth, Hendrik
T1  - Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]
Y1  - 2010
SP  - 1
EP  - 30
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - PAT
A1  - Siegert, Petra
A1  - Spitz, Astrid
A1  - Maurer, Karl-Heinz
T1  - Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]
T1  - Novel proteases and compositions comprising these proteases [Internationale Patentanmeldung]
Y1  - 2010
SP  - 1
EP  - 31
PB  - Deutsches Patentamt / WIPO
CY  - München / Genf
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Mang, Thomas
T1  - Neue Technik mit magnetisierbaren Materialien : Offenlegungsschrift DE102004005201A1 ; Offenlegungstag: 11.08.2005
Y1  - 2005
N1  - Volltext über Datenbank DEPATISnet
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Schwarzer, Klemens
T1  - Neuer Wärmeträger für Solaranlagen : Offenlegungsschrift : DE 102007016738 A1 ; Offenlegungstag: 09.10.2008
Y1  - 2008
N1  - Volltext über Datenbank DEPATISnet: http://depatisnet.dpma.de/DepatisNet/depatisnet?action=pdf&docid=DE102007016738A1
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - JOUR
A1  - Selmer, Thorsten
A1  - Pierik, Antonio J.
A1  - Heider, Johann
T1  - New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria
JF  - Biological Chemistry. 386 (2005), H. 10
Y1  - 2005
SN  - 1431-6730
SP  - 981
EP  - 988
ER  - 
TY  - JOUR
A1  - Scherer, Ulrich W.
A1  - Kratz, J. V.
A1  - Gober, M. K.
A1  - Zimmermann, H. P.
T1  - New nuclide 263 105 / J.V. Kratz, M.K. Gober, H.P. Zimmermann, M. Schädel, W. Brüchle, E. Schimpf, K.E. Gregorich, A. Türler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M.J. Nurmia, D.C. Hoffman, H. Gäggeler, D. Jost, U.W. Scherer, A. Weber
JF  - Physical Review C . 45 (1992)
Y1  - 1992
SP  - 1064
EP  - 1069
ER  - 
TY  - JOUR
A1  - Falkenberg, Fabian
A1  - Voß, Leonie
A1  - Bott, Michael
A1  - Bongaerts, Johannes
A1  - Siegert, Petra
T1  - New robust subtilisins from halotolerant and halophilic Bacillaceae
JF  - Applied Microbiology and Biotechnology
N2  - The aim of the present study was the characterisation of three true subtilisins and one phylogenetically intermediate subtilisin from halotolerant and halophilic microorganisms. Considering the currently growing enzyme market for efficient and novel biocatalysts, data mining is a promising source for novel, as yet uncharacterised enzymes, especially from halophilic or halotolerant Bacillaceae, which offer great potential to meet industrial needs. Both halophilic bacteria Pontibacillus marinus DSM 16465ᵀ and Alkalibacillus haloalkaliphilus DSM 5271ᵀ and both halotolerant bacteria Metabacillus indicus DSM 16189 and Litchfieldia alkalitelluris DSM 16976ᵀ served as a source for the four new subtilisins SPPM, SPAH, SPMI and SPLA. The protease genes were cloned and expressed in Bacillus subtilis DB104. Purification to apparent homogeneity was achieved by ethanol precipitation, desalting and ion-exchange chromatography. Enzyme activity could be observed between pH 5.0–12.0 with an optimum for SPPM, SPMI and SPLA around pH 9.0 and for SPAH at pH 10.0. The optimal temperature for SPMI and SPLA was 70 °C and for SPPM and SPAH 55 °C and 50 °C, respectively. All proteases showed high stability towards 5% (w/v) SDS and were active even at NaCl concentrations of 5 M. The four proteases demonstrate potential for future biotechnological applications.
KW  - Biotechnological application
KW  - Bacillaceae
KW  - Subtilisin
KW  - Subtilases
KW  - Halotolerant protease
Y1  - 2023
U6  - http://dx.doi.org/10.1007/s00253-023-12553-w
SN  - 1432-0614
N1  - Corresponding author: Petra Siegert
VL  - 107
SP  - 3939
EP  - 3954
PB  - Springer Nature
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Thiel, Alexander
A1  - Tippkötter, Nils
A1  - Suck, Kirstin
A1  - Sohling, Ulrich
A1  - Ruf, Friedrich
A1  - Ulber, Roland
T1  - New zeolite adsorbents for downstream processing of polyphenols from renewable resources
JF  - Engineering in Life Sciences
N2  - Commercial materials with polyvinylpolypyrrolidone and polymeric amberlites (XAD7HP, XAD16) are commonly used for the adsorptive downstream processing of polyphenols from renewable resources. In this study, beta-zeolite-based adsorbent systems were examined, and their properties were compared to organic resins. Batch adsorption experiments were conducted with synthetic solutions of major polyphenols. Adsorption isotherms and desorption characteristics of individual adsorbent were determined based on these results. Maximum adsorption capacities were calculated using the Langmuir model. For example, the zeolites had capacities up to 203.2 mg/g for ferulic acid. To extend these results to a complex system, additional experiments were performed on rapeseed meal and wheat seed extracts as representative renewable resources. HPLC analysis showed that with 7.5% w/v, which is regarded as the optimum amount of zeolites, zeolites A and B could bind 100% of the major polyphenols as well as release polyphenols at high yields. Additionally, regeneration experiments were performed with isopropyl alcohol at 99°C to evaluate how zeolites regenerate under mild conditions. The results showed only a negligible loss of adsorption capacity and no loss of desorption capacity. In summary, it was concluded that beta-zeolites were promising adsorbents for developing new processes to isolate polyphenols from renewable resources.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/elsc.201200188
VL  - 13
IS  - 3
SP  - 239
EP  - 246
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Seubert, Bernhard
A1  - Beilharz, Helmut
A1  - Fickert, Werner [u.a.]
T1  - Niedermolekulare Alkalihuminate : Verfahren zu ihrer Herstellung und Verwendung ; Offenlegungsschrift DE3707909A1 ; Offenlegungstag: 22.09.1988 / Anmelder: Rütgerswerke AG, 6000 Frankfurt. Erfinder: Bernhard Seubert ; Helmut Beilharz ; Werner Fickert ; Günter Jeromin ...
Y1  - 1988
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - PAT
A1  - Jeromin, Günter Erich
A1  - Seubert, Bernhard
A1  - Beilharz, Helmut
A1  - Fickert, Werner [u.a.]
T1  - Niedermolekulare Alkalihuminate : Verfahren zur ihrer Herstellung und Verwendung ; Europäische Patentschrift EP0281679B1 ; Veröffentlichungstag im Patentblatt: 01.08.1991 / Anmelder: Rütgerswerke AG, 6000 Frankfurt. Erfinder: Bernhard Seubert ; Helmut Beilharz ; Günter Jeromin ; Werner Fickert ...
Y1  - 1991
N1  - Volltext über Datenbank: http://publikationen.dpma.de/
PB  - Deutsches Patent- und Markenamt
CY  - München
ER  - 
TY  - JOUR
A1  - Elbers, Gereon
A1  - Gäb, Martina
A1  - Hoffmann, Katharina
A1  - Lobe, Melanie
T1  - NIR-spectroscopic investigation of foliage of ozone-stressed Fagus sylvatica trees / Gäb, Martina ; Hoffmann, Katharina ; Lobe, Melanie ; Metzger, Rut ; Ooyen, Sven van ; Elbers, Gereon ; Köllner, Barbara
JF  - Journal of Forest Research. 11 (2006), H. 2
Y1  - 2006
SN  - 1341-6979
SP  - 69
EP  - 75
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roikaew, W.
A1  - Ulber, R.
T1  - Nitrate removal from whey concentrate with biotechnological regeneration of the waste water
JF  - European dairy magazine : EDM
Y1  - 2008
SN  - 0936-6318
IS  - 1
SP  - 30
EP  - 32
ER  - 
TY  - JOUR
A1  - Tippkötter, Nils
A1  - Roikaew, N.
A1  - Ulber, R.
T1  - Nitratentfernung aus Molkekonzentrat mit biotechnologischer Regeneration der Abwässer
JF  - Deutsche Milchwirtschaft
Y1  - 2007
SN  - 0012-0480
VL  - 58
IS  - 15
SP  - 540
EP  - 542
ER  - 
TY  - JOUR
A1  - Ulber, Roland
A1  - Tippkötter, Nils
T1  - Nitratfreie Molke
JF  - Rundschau für Fleischhygiene und Lebensmittelüberwachung
Y1  - 2009
IS  - 4
SP  - 150
EP  - 152
ER  -