TY - CHAP A1 - Thenent, N. E. A1 - Dahmann, Peter T1 - Hydrostatic propeller drive T2 - Proceedings of the conference : 18 - 20 May, 2011 Tampere, Finland / the Twelth Scandinavian International Conference on Fluid Power, SICFP'11. Ed.: Harri Sairiala ... Vol. 1 Y1 - 2011 SN - 978-952-15-2517-9 SP - 217 EP - 227 CY - Tampere ER - TY - JOUR A1 - Schwarzer, Klemens A1 - Vieira da Silva, Maria Eugenia A1 - Schwarzer, Tarik T1 - Field results in Namibia and Brazil of the new solar desalination system for decentralised drinking water production JF - Desalination and water treatment. Vol. 31 (2011), iss. 1-3: selected papers presented at EuroMed 2010 — Desalination for Clean Water and Energy: Cooperation among Mediterranean Countries of Europe and MENA Region, 3–7 October 2010, Tel Aviv, Israel Y1 - 2011 SP - 379 EP - 386 ER - TY - CHAP A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard A1 - Rau, Christoph A1 - Sattler, Johannes, Christoph T1 - Choice of solar share of a hybrid power plant of a central receiver system and a biogas plant in dependency of the geographical latitude T2 - World Renewable Energy Congress-Sweden : 8 -13 May, 2011, Linköping, Sweden / ed.: Bahram Moshfegh Y1 - 2011 SN - 9789173930703 SP - 3710 EP - 3717 PB - Univ. Electronic Pr. CY - Linköping ER - TY - CHAP A1 - Hoffschmidt, Bernhard A1 - Telle, R. A1 - Sauerborn, Markus A1 - Wagner, M. T1 - Optical measurement system for high temperature absorbers T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Teixeira Boura, Cristiano José A1 - Eckstein, J. A1 - Felinks, J. A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard A1 - Schmitz, S. T1 - 3-D CFD simulation of an air-sand heat exchanger T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Baumann, Torsten A1 - Teixeira Boura, Cristiano José A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard A1 - Schmitz, Stefan A1 - Zunft, Stefan T1 - Air-sand heat exchanger: materials and flow properties T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Achenbach, Timm A1 - Göttsche, Joachim A1 - Kaufhold, O. A1 - Hoffschmidt, Bernhard T1 - Development of an edge module for open volumetric receiver for the use of the radiation at the receiver boundary region T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Achenbach, Timm A1 - Geimer, K. A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard A1 - Lynen, A. A1 - Bauer, J. T1 - Simulation and flow measurements of volumetric high temperature absorbers for solar tower power plants T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Hirsch, Tobias A1 - Ahlbrink, Nils A1 - Pitz-Paal, Robert A1 - Teixeira Boura, Cristiano José A1 - Hoffschmidt, Bernhard A1 - Gall, Jan A1 - Abel, Dirk A1 - Nolte, Vera A1 - Wirsum, Manfred A1 - Andersson, Joel A1 - Diehl, Moritz T1 - Dynamic simulation of a solar tower system with open volumetric receiver - a review on the ViCERP project T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Fricke, Barbara A1 - Ziolko, C. A1 - Anthrakidis, Anette A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard A1 - Dillig, M. A1 - Giese, F. T1 - InnoSol - life cycle analysis of solar power tower plants T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard A1 - Rau, Christoph T1 - Comparison of steady-state and transient simulations for solar tower power plants with open-volumetric receiver T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - CHAP A1 - Sauerborn, Markus T1 - Investigations to the influence of clouds and aerosols to the haze of the sunshape T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - JOUR A1 - Mukherjee, Krishnendu A1 - Ramazani, Ali A1 - Yang, Li A1 - Prahl, Ulrich A1 - Bleck, Wolfgang A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Abdurakhmanov, Aydemir T1 - Characterization of gas metal arc welded hot rolled DP600 steel JF - Steel research international Y1 - 2011 SN - 1869-344X (E-Book); 1611-3683 (Print) VL - Vol. 82 IS - Iss. 12 SP - 1408 EP - 1416 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Abdurakhmanov, Aydemir A1 - Turichin, Gleb A1 - Valdaitseva, Elena A1 - Bach, Friedrich-Wilhelm A1 - Hassel, Thomas A1 - Beniyashi, Alexander T1 - Investigation of factors for defect-free weld formation by non-vacuum electron beam welding T2 - Laser technologies in welding and materials processing : proceedings of the fifth international conference, 24 - 27 May 2011, Katsiveli, Crimea, Ukraine Y1 - 2011 SP - 104 EP - 109 PB - Paton Publ. House CY - Kiev ER - TY - JOUR A1 - Glowania, Michael A1 - Gries, Thomas A1 - Schoene, Jens A1 - Schleser, Markus A1 - Reisgen, Uwe T1 - Innovative coating technology for textile reinforcements of concrete applications JF - 13th International Congress on Polymers in Concrete : 10 - 12 February 2010, Funchal, Madeira, Portugal.(Key engineering materials. Vol. 466) Y1 - 2011 SN - 978-3-03785-008-4 SN - 1013-9826 (E-Journal) ; 0252-1059 (Print) SP - 167 EP - 173 PB - Trans Tech Publications CY - Bäch ER - TY - JOUR A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Mokrov, Oleg A1 - Ahmed, Essam T1 - Numerical and experimental investigation of tensile behavior of laser beam welded TRIP700 steel JF - ISIJ international Y1 - 2011 SN - 1347-5460 (E-Journal); 0915-1559 (Print) VL - Vol. 51 IS - No. 3 SP - 429 EP - 434 PB - ISIJ CY - Tōkyō ER - TY - CHAP A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Scheik, Sven A1 - Michaeli, Walter A1 - Grönlund, Oliver A1 - Neuß, Andreas A1 - Wunderle, Johannes A1 - Poprawe, Reinhart A1 - Rösner, A. A1 - Bobzin, Kirsten A1 - Schläfer, Thomas A1 - Theiß, Sebastian A1 - Kutschmann, Pia A1 - Haberstroh, Edmund A1 - Flock, Dustin A1 - Bührig-Polaczek, Andreas A1 - Jakob, M. ED - Thoben, Klaus-Dieter T1 - Novel process chains for the production of plastics/metal-hybrids T2 - 17th International Conference on Concurrent Enterprising (ICE 2011) : Aachen, Germany, 20 - 22 June 2011 Y1 - 2011 SN - 978-1-457-70772-8 ; 978-3-943024-05-0 SP - 596 EP - 604 PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Roesner, Andreas A1 - Scheik, Sven A1 - Olowinsky, Alexander A1 - Gillner, Arnold A1 - Propawe, Reinhart A1 - Schleser, Markus A1 - Reisgen, Uwe T1 - Innovative approach of joining hybrid components JF - Journal of laser applications Y1 - 2011 SN - 1042-346X VL - Vol. 23 IS - Iss. 3 SP - 32007 PB - Laser Institute of America CY - Orlando, Fla. ER - TY - JOUR A1 - Roesner, Andreas A1 - Scheik, Sven A1 - Olowinsky, Alexander A1 - Gillner, Arnold A1 - Reisgen, Uwe A1 - Schleser, Markus T1 - Laser assisted joining of plastic metal hybrids JF - Lasers in manufacturing 2011 : proceedings of the sixth International WLT Conference on Lasers in Manufacturing, Munich, May 23 - 26 2011. (Physics procedia ; Vol. 12 (2011), Part B) Y1 - 2011 SN - 1875-3892 (E-Journal); 1875-3884 (Print) SP - 370 EP - 377 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Mokrov, Oleg A1 - Zabirov, Alexander T1 - Virtual welding equipment for simulation of GMAW processes with integration of power source regulation JF - Frontiers of materials science Y1 - 2011 SN - 2095-0268 (E-Journal); 2095-025X (Print) VL - Vol. 5 IS - Iss. 2 SP - 79 EP - 89 PB - Springer CY - Berlin ER - TY - CHAP A1 - Huber, Frédéric A1 - Bleck, Wolfgang A1 - Scheik, Sven A1 - Schleser, Markus A1 - Reisgen, Uwe T1 - Investigation of galvanneal coating adherence in adhesive bonded joints using lap shear test T2 - Galvatech 2011 : 8th International Conference on Zinc and Zinc Alloy Coated Steel Sheet, June 21 - 24, 2011, Genova (Italy) ; proceedings Y1 - 2011 SN - 978-88-85298-82-8 SP - Paper No. 43 PB - Associazione Italiana di Metallurgia CY - Mailand ER - TY - JOUR A1 - Deppe, Veronika Maria A1 - Bongaerts, Johannes A1 - O'Connell, Timothy A1 - Maurer, Karl-Heinz A1 - Meinhardt, Friedhelm T1 - Enzymatic deglycation of Amadori products in bacteria JF - Applied microbiology and biotechnology Y1 - 2011 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 90 IS - Iss. 2 SP - 399 EP - 406 PB - Springer CY - Berlin ER - TY - JOUR A1 - Deppe, Veronika Maria A1 - Klatte, Stephanie A1 - Bongaerts, Johannes A1 - Maurer, Karl-Heinz A1 - O'Connell, Timothy A1 - Meinhardt, Friedhelm T1 - Genetic control of Amadori product degradation in Bacillus subtilis via regulation of frlBONMD expression by FrlR JF - Applied and environmental microbiology Y1 - 2011 SN - 1098-5336 (E-Journal); 0003-6919 (Print); 0099-2240 (Print) VL - Vol. 77 IS - No. 9 SP - 2839 EP - 2846 PB - American Society of Mechanical Engineers (ASME) CY - New York ER - TY - JOUR A1 - Bongaerts, Johannes A1 - Esser, Simon A1 - Lorbach, Volker A1 - Al-Momani, Lóay A1 - Müller, Michael A. A1 - Franke, Dirk A1 - Grondal, Christoph A1 - Kurutsch, Anja A1 - Bujnicki, Robert A1 - Takors, Ralf A1 - Raeven, Leon A1 - Wubbolts, Marcel A1 - Bovenberg, Roel A1 - Nieger, Martin A1 - Schürmann, Melanie A1 - Trachtmann, Natalie A1 - Kozak, Stefan A1 - Sprenger, Georg A. A1 - Müller, Michael T1 - Diversity-oriented production of metabolites derived from chorismate and their use in organic synthesis JF - Angewandte Chemie International Edition Y1 - 2011 SN - 1521-3773 (E-Journal); 0570-0833 (Print); 1433-7851 (Print) VL - Vol. 50 IS - Iss. 34 SP - 7781 EP - 7786 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Bung, Daniel B. T1 - Developing flow in skimming flow regime on embankment stepped spillways JF - Journal of hydraulic research Y1 - 2011 SN - 1814-2079 (E-Journal); 0022-1686 (Print) VL - Vol. 49 IS - Iss. 5 SP - 639 EP - 648 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Bung, Daniel B. T1 - Non-intrusive measuring of air-water flow properties in self-aerated stepped spillway flow T2 - Balance and uncertainty - water in a changing world : proceedings of the 34th IAHR world congress ; 33rd Hydrology and Water Resources Symposium ; 10th Conference on Hydraulics in Water Engineering ; 26 June - 1 July 2011, Brisbane, Australia Y1 - 2011 SN - 978-0-85825-868-6 SP - 2380 EP - 2387 ER - TY - CHAP A1 - Ahmed, H. A1 - Schlenkhoff, A. A1 - Bung, Daniel B. T1 - Hydrodynamic characteristics of vertical slotted wall breakwaters T2 - Balance and uncertainty - water in a changing world : proceedings of the 34th IAHR world congress ; 33rd Hydrology and Water Resources Symposium ; 10th Conference on Hydraulics in Water Engineering ; 26 June - 1 July 2011, Brisbane, Australia Y1 - 2011 SN - 978-0-85825-868-6 SP - 1179 EP - 1186 ER - TY - CHAP A1 - Döring, Bernd A1 - Kuhnhenne, Markus A1 - Feldmann, Markus T1 - Floor systems - key elements for sustainable multi-storey buildings T2 - SB11 Helsinki World Sustainable Building Conference : 18. - 21.10.2011 Y1 - 2011 SP - 1 EP - 6 ER - TY - CHAP A1 - Schneckenburger, N. A1 - Franzen, N. A1 - Gligorevic, Snjezana A1 - Schnell, M. T1 - L-band compatibility of LDACS1 T2 - IEEE/AIAA 30th Digital Avionics Systems Conference (DASC) : 16 - 20 Oct. 2011, Seattle, Wash. Y1 - 2011 SN - 978-1-61284-797-9 SN - 2155-7195 SP - 4C3-1 EP - 4C3-11 ER - TY - CHAP A1 - Gligorevic, Snjezana A1 - Schneckenburger, N. A1 - Franzen, N. A1 - Schnell, Michael A1 - Müller, S. A1 - Günzel, H. T1 - L-Band compatibility of LDACS1 T2 - 3rd CEAS Air and Space Conference, 24 - 28 October 2011, Venezia, Italy Y1 - 2011 SP - 1 EP - 8 ER - TY - CHAP A1 - Gligorevic, Snjezana A1 - Epple, Ulrich A1 - Schnell, Michael T1 - The LDACS1 physical layer design T2 - Future aeronautical communications Y1 - 2011 SN - 978-953-307-625-6 SP - 317 EP - 332 PB - Intech CY - London ER - TY - CHAP A1 - Usai, Pierpaolo A1 - Corucci, Alessandro A1 - Gligorevic, Snjezana A1 - Monorchio, Agostino T1 - Estimation of airport surface propagation channel: ray tracing model and measurements T2 - Proceedings of the 5th European Conference on Antennas and Propagation (EUCAP) : 11 - 15 April 2011, Rome, Italy Y1 - 2011 SN - 978-1-4577-0250-1 SP - 1634 EP - 1638 ER - TY - CHAP A1 - Schiffer, Stefan A1 - Ferrein, Alexander A1 - Lakemeyer, Gerhard T1 - Fuzzy representations and control for domestic service robots in Golog T2 - Intelligent robotics and applications : 4th International conference, ICIRA 2011, Aachen, Germany, December 6-8, 2011, proceedings, part I. (Lecture notes in computer science ; 7102) Y1 - 2011 SN - 978-3-642-25486-4 SP - 241 EP - 250 ER - TY - JOUR A1 - Niehaus, F. A1 - Gabor, E. A1 - Wieland, S. A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Eck, J. T1 - Enzymes for the laundry industries: tapping the vast metagenomic pool of alkaline proteases JF - Microbial biotechnology Y1 - 2011 SN - 1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print) VL - Vol. 4 IS - Iss. 6 SP - 767 EP - 776 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ribitsch, D. A1 - Heumann, S. A1 - Trotscha, E. A1 - Herrero Acero, E. A1 - Greimel, K. A1 - Leber, R. A1 - Birger-Gruenberger, R. A1 - Deller, S. A1 - Eiteljoerg, I. A1 - Remler, P. A1 - Weber, Th. A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Donelli, I. A1 - Freddi, G. A1 - Schwab, H. A1 - Guebitz, G. M. T1 - Hydrolysis of polyethyleneterephthalate by p-nitrobenzylesterase from Bacillus subtilis JF - Biotechnology progress Y1 - 2011 SN - 1520-6033 (E-Journal); 8756-7938 (Print) VL - Vol. 27 IS - Iss. 4 SP - 951 EP - 960 PB - Wiley CY - Hoboken ER - TY - CHAP A1 - Pfaff, Raphael A1 - Larkowski, Tomasz A1 - Burnham, Keith J. T1 - An application of adaptive control in the behavioural framework T2 - 21st International Conference on Systems Engineering (ICSEng) : 16 - 18 Aug. 2011, Las Vegas, Nevada ; proceedings Y1 - 2011 SN - 978-1-4577-1078-0 ; 978-0-7695-4495-3 SP - 49 EP - 54 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Bragard, Michael A1 - Ronge, C. A1 - De Doncker, R. W. T1 - Sandwich design of high-power thyristor based devices with integrated MOSFET structure T2 - Proceedings of the 2011 - 14th - European Conference on Power Electronics and Applications (EPE 2011) : Aug. 30, 2011 - Sept. 1, 2011, Birmingham, United Kingdom Y1 - 2011 SN - 978-1-61284-167-0 (Print) SN - 978-90-75815-15-3 (Online) PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Bragard, Michael A1 - Gottschlich, J. A1 - De Doncker, R. W. T1 - Design and realization of a credit card size driver stage for high power thyristor based devices with integrated MOS structure T2 - 2011 IEEE 8th International Conference on Power Electronics and ECCE Asia (ICPE & ECCE 2011) : Jeju, South Korea, 30 May 2011 - 3 June 2011 / [co-sponsored by the Korean Institute of Power Electronics ...] Y1 - 2011 SN - 978-1-61284-958-4 (Print) SN - 978-1-61284-956-0 (Online) U6 - http://dx.doi.org/10.1109/ICPE.2011.5944661 SP - 1182 EP - 1189 PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Eilmann, Britta A1 - Zweifel, Roman A1 - Buchmann, Nina A1 - Graf Pannatier, Elisabeth A1 - Rigling, Andreas T1 - Drought alters timing, quantity, and quality of wood formation in Scots pine JF - Journal of Experimental Botany Y1 - 2011 U6 - http://dx.doi.org/10.1093/jxb/erq443 SN - 1460-2431 (Online) SN - 0022-0957 (Print) VL - 62 IS - 8 SP - 2763 EP - 2771 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Bragard, Michael A1 - Conrad, M. A1 - van Hoek, H. A1 - De Doncker, R. W. T1 - The integrated emitter turn-off thyristor (IETO) : an innovative thyristor-based high power semiconductor device using MOS assisted turn-off JF - IEEE transactions on industry applications Y1 - 2011 U6 - http://dx.doi.org/10.1109/TIA.2011.2161432 SN - 0093-9994 VL - 47 IS - 5 SP - 2175 EP - 2182 PB - IEEE CY - New York ER - TY - JOUR A1 - Wagner, Torsten A1 - Miyamoto, K. A1 - Werner, Frederik A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) Y1 - 2011 U6 - http://dx.doi.org/10.1166/sl.2011.1620 VL - 9 IS - 2 SP - 812 EP - 815 PB - American Scientific Publishers CY - Stevenson Ranch, Calif. ER - TY - CHAP A1 - Damm, Sebastian A1 - Ritz, Thomas A1 - Strauch, Jakob T1 - Adaption of archetype patterns for mobile cloud-based business apps T2 - 2011 IEEE International Conference on Pervasive Computing and Communications workshops (PerCom workshops 2011) : Seattle, Washington, USA, 21 - 25 March 2011 Y1 - 2011 SN - 978-1-61284-938-6 (Print) SN - 978-1-61284-936-2 (E-Book) U6 - http://dx.doi.org/10.1109/PERCOMW.2011.5766849 SP - 100 EP - 105 PB - IEEE Service Center CY - Piscataway, NJ ER - TY - CHAP A1 - Fuchs, Britta A1 - Ritz, Thomas A1 - Halbach, Bastian A1 - Hartl, Florian ED - Marca, David A. T1 - Blended shopping : interactivity and individualization T2 - Proceedings of the International Conference on e-Business : Seville, Spain, 18 - 21 July 2011 ; [... integrated in the ICETE (International Conference on e-Business and Telecommunications) joint conference] Y1 - 2011 SN - 978-989-8425-70-6 SP - 47 EP - 52 PB - SciTePress CY - [Lissabon] ER - TY - CHAP A1 - Stieglitz, Kristian A1 - Wollert, Jörg T1 - Approach of using ultra-wideband-radio in industrial real-time ethernet networks T2 - The 4th International Multi-Conference on Engineering and Technological Innovation : IMETI : July 19th - July 22nd, 2011, Orlando, Florida, USA Y1 - 2011 SP - 1 EP - 6 ER - TY - JOUR A1 - Raab, Monika A1 - Kappel, Sven A1 - Krämer, Andrea A1 - Sanhaji, Mourad A1 - Matthess, Yves A1 - Kurunci-Csacsko, Elisabeth A1 - Calzada-Wack, Julia A1 - Rathkolb, Birgit A1 - Rosman, Jan A1 - Adler, Thure A1 - Busch, Dirk H. A1 - Esposito, Irene A1 - Fuchs, Helmut A1 - Gailus-Durner, Valérie A1 - Klingenspor, Martin A1 - Wolf, Eckhard A1 - Sänger, Nicole A1 - Prinz, Florian A1 - Hrabe de Angelis, Martin A1 - Seibler, Jost A1 - Yuan, Juping A1 - Bergmann, Martin A1 - Knecht, Rainald A1 - Kreft, Bertolt A1 - Strebhardt, Klaus T1 - Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells JF - Nature Communications Y1 - 2011 U6 - http://dx.doi.org/10.1038/ncomms1395 SN - 2041-1723 VL - 2 IS - 395 SP - 1 EP - 11 PB - Nature CY - London ER - TY - JOUR A1 - Hasegawa, Maki A1 - Kapelyukh, Yury A1 - Tahara, Harunobu A1 - Seibler, Jost A1 - Rode, Anja A1 - Krueger, Sylvia A1 - Lee, Dongtao N. A1 - Wolf, C. Roland A1 - Scheer, Nico T1 - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line JF - Molecular Pharmacology Y1 - 2011 U6 - http://dx.doi.org/10.1124/mol.111.071845 SN - 1521-0111 VL - 80 IS - 33 SP - 518 EP - 528 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Jordan, Sabine D. A1 - Krüger, Markus A1 - Willmes, Diana M. A1 - Redemann, Nora A1 - Wunderlich, F. Thomas A1 - Brönneke, Hella S. A1 - Merkwirth, Carsten A1 - Kashkar, Hamid A1 - Olkkonen, Vesa M. A1 - Böttger, Thomas A1 - Braun, Thomas A1 - Seibler, Jost A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism JF - Nature Cell Biology N2 - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes. Y1 - 2011 U6 - http://dx.doi.org/10.1038/ncb2211 SN - 1465-7392 VL - 13 IS - 4 SP - 434 EP - 446 PB - Nature CY - New York ER - TY - JOUR A1 - Inagaki, Akiko A1 - Sleddens-Linkels, Esther A1 - Wassenaar, Evelyne A1 - Ooms, Marja A1 - Cappellen, Wiggert A. van A1 - Hoeijmakers, Jan H. J. A1 - Seibler, Jost A1 - Vogt, Thomas F. A1 - Shin, Myung K. A1 - Grootegoed, J. Anton A1 - Baarends, Willy M. T1 - Meiotic functions of RAD18 JF - Journal of Cell Science Y1 - 2011 U6 - http://dx.doi.org/10.1242/jcs.081968 SN - 1477-9137 VL - 124 IS - 16 SP - 2837 EP - 2850 PB - Company of Biologists Limited CY - Cambridge ER - TY - CHAP A1 - Fissabre, Anke A1 - Niethammer, Bernd ED - Graf, Franz T1 - Early Glazed Curtain Walls and their Preservation T2 - Il vetro nell’architettura del XX secolo : conservazione e restauro = Glass in the 20th Century Architecture : Preservation and Restoration Y1 - 2011 SN - 9788887624502 SP - 185 EP - 199 PB - Mendrisio Academy Press CY - Mendrisio ER - TY - JOUR A1 - Mottaghy, Darius A1 - Pechnig, Renate A1 - Vogt, Christian T1 - The geothermal project Den Haag: 3D numerical models for temperature prediction and reservoir simulation JF - Geothermics N2 - The proposed Den Haag Zuidwest district heating system of the city of The Hague consists of a deep doublet in a Jurassic sandstone layer that is designed for a production temperature of 75 °C and a reinjection temperature of 40 °C at a flow rate of 150 m3 h−1. The prediction of reservoir temperature and production behavior is crucial for success of the proposed geothermal doublet. This work presents the results of a study of the important geothermal and geohydrological issues for the doublet design. In the first phase of the study, the influences of the three-dimensional (3D) structures of anticlines and synclines on the temperature field were examined. A comprehensive petrophysical investigation was performed to build a large scale 3D-model of the reservoir. Several bottomhole temperatures (BHTs), as well as petrophysical logs were used to calibrate the model using thermal conductivity measurements on 50 samples from boreholes in different lithological units in the study area. Profiles and cross sections extracted from the calculated temperature field were used to study the temperature in the surrounding areas of the planned doublet. In the second phase of the project, a detailed 3D numerical reservoir model was set up, with the aim of predicting the evolution of the producer and injector temperatures, and the extent of the cooled area around the injector. The temperature model from the first phase provided the boundary conditions for the reservoir model. Hydraulic parameters for the target horizons, such as porosity and permeability, were taken from data available from the nearby exploration wells. The simulation results are encouraging as no significant thermal breakthrough is predicted. For the originally planned location of the producer, the extracted water temperature is predicted to be around 79 °C, with an almost negligible cooling in the first 50 years of production. When the producer is located shallower parts of the reservoir, the yield water temperatures is lower, starting at ≈76 °C and decreasing to ≈74 °C after 50 years of operation. This comparatively larger decrease in temperature with time is caused by the structural feature of the reservoir, namely a higher dip causes the cooler water to easily move downward. In view of the poor reservoir data, the reservoir simulation model is constructed to allow iterative updates using data assimilation during planned drilling, testing, and production phases. Measurements during an 8 h pumping test carried out in late 2010 suggest that a flow rate of 150 m3 h−1 is achievable. Fluid temperatures of 76.5 °C were measured, which is very close to the predicted value. Y1 - 2011 U6 - http://dx.doi.org/10.1016/j.geothermics.2011.07.001 SN - 0375-6505 VL - 40 IS - 3 SP - 199 EP - 210 PB - Elsevier CY - Amsterdam ER -