TY  - JOUR
A1  - Grieger, Niklas
A1  - Schwabedal, Justus T. C.
A1  - Wendel, Stefanie
A1  - Ritze, Yvonne
A1  - Bialonski, Stephan
T1  - Automated scoring of pre-REM sleep in mice with deep learning
JF  - Scientific Reports
N2  - Reliable automation of the labor-intensive manual task of scoring animal sleep can facilitate the analysis of long-term sleep studies. In recent years, deep-learning-based systems, which learn optimal features from the data, increased scoring accuracies for the classical sleep stages of Wake, REM, and Non-REM. Meanwhile, it has been recognized that the statistics of transitional stages such as pre-REM, found between Non-REM and REM, may hold additional insight into the physiology of sleep and are now under vivid investigation. We propose a classification system based on a simple neural network architecture that scores the classical stages as well as pre-REM sleep in mice. When restricted to the classical stages, the optimized network showed state-of-the-art classification performance with an out-of-sample F1 score of 0.95 in male C57BL/6J mice. When unrestricted, the network showed lower F1 scores on pre-REM (0.5) compared to the classical stages. The result is comparable to previous attempts to score transitional stages in other species such as transition sleep in rats or N1 sleep in humans. Nevertheless, we observed that the sequence of predictions including pre-REM typically transitioned from Non-REM to REM reflecting sleep dynamics observed by human scorers. Our findings provide further evidence for the difficulty of scoring transitional sleep stages, likely because such stages of sleep are under-represented in typical data sets or show large inter-scorer variability. We further provide our source code and an online platform to run predictions with our trained network.
Y1  - 2021
U6  - http://dx.doi.org/10.1038/s41598-021-91286-0
SN  - 2045-2322
N1  - Corresponding author: Stephan Bialonski
VL  - 11
IS  - Art. 12245
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Ball, Christopher Stephen
A1  - Vögele, Stefan
A1  - Grajewski, Matthias
A1  - Kuckshinrichs, Wilhelm
T1  - E-mobility from a multi-actor point of view: Uncertainties and their impacts
JF  - Technological Forecasting and Social Change
Y1  - 2021
SN  - 0040-1625
U6  - http://dx.doi.org/10.1016/j.techfore.2021.120925
VL  - 170
IS  - Art. 120925
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Slabu, Ioana
T1  - Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating
T2  - Magnetic nanoparticles in human health and medicine
Y1  - 2021
SN  - 978-1-119-75467-1
SP  - 327
EP  - 354
PB  - Wiley-Blackwell
CY  - Hoboken, New Jeersey
ER  - 
TY  - CHAP
A1  - Bornheim, Tobias
A1  - Grieger, Niklas
A1  - Bialonski, Stephan
T1  - FHAC at GermEval 2021: Identifying German toxic, engaging, and fact-claiming comments with ensemble learning
T2  - Proceedings of the GermEval 2021 Workshop on the Identification of Toxic, Engaging, and Fact-Claiming Comments : 17th Conference on Natural Language Processing KONVENS 2021
Y1  - 2021
U6  - http://dx.doi.org/10.48415/2021/fhw5-x128
N1  - <Conference on Natural Language Processing, KONVENS, 17, 2021>
SP  - 105
EP  - 111
PB  - Heinrich Heine University
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Hagenkamp, Markus
A1  - Blanke, Tobias
A1  - Döring, Bernd
T1  - Thermoelectric building temperature control: a potential assessment
JF  - International Journal of Energy and Environmental Engineering
N2  - This study focuses on thermoelectric elements (TEE) as an alternative for room temperature control. TEE are semi-conductor devices that can provide heating and cooling via a heat pump effect without direct noise emissions and no refrigerant use. An efficiency evaluation of the optimal operating mode is carried out for different numbers of TEE, ambient temperatures, and heating loads. The influence of an additional heat recovery unit on system efficiency and an unevenly distributed heating demand are examined. The results show that TEE can provide heat at a coefficient of performance (COP) greater than one especially for small heating demands and high ambient temperatures. The efficiency increases with the number of elements in the system and is subject to economies of scale. The best COP exceeds six at optimal operating conditions. An additional heat recovery unit proves beneficial for low ambient temperatures and systems with few TEE. It makes COPs above one possible at ambient temperatures below 0 ∘C. The effect increases efficiency by maximal 0.81 (from 1.90 to 2.71) at ambient temperature 5 K below room temperature and heating demand Q˙h=100W but is subject to diseconomies of scale. Thermoelectric technology is a valuable option for electricity-based heat supply and can provide cooling and ventilation functions. A careful system design as well as an additional heat recovery unit significantly benefits the performance. This makes TEE superior to direct current heating systems and competitive to heat pumps for small scale applications with focus on avoiding noise and harmful refrigerants.
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s40095-021-00424-x
N1  - Corresponding author: Markus Hagenkamp
VL  - 13
SP  - 241
EP  - 254
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Kern, Alexander
A1  - Imani Vashiani, Anahita
A1  - Timmermanns, Tobias
T1  - Threat for human beings due to touch voltages and body currents caused by direct lightning strikes in case of non-isolated lightning protection systems using natural components
T2  - 35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)
N2  - For typical cases of non-isolated lightning
protection systems (LPS) the impulse currents are investigated which may flow through a human body directly touching a structural part of the LPS. Based on a basic LPS model with conventional down-conductors especially the cases of external and internal steel columns and metal façades are considered and compared. Numerical simulations of the line quantities voltages and currents in the time domain are performed with an equivalent circuit of the entire LPS.
As a result it can be stated that by increasing the number of conventional down-conductors and external steel columns the threat for a human being can indeed be reduced, but not down to an acceptable limit. In case of internal steel columns used as natural down-conductors the threat can be reduced sufficiently, depending on the low-resistive connection of the steel columns to the lightning equipotential bonding or the earth termination system, resp. If a metal façade is used the threat for human beings touching is usually very low, if the façade is sufficiently interconnected and multiply connected to the lightning equipotential bonding or the earth termination system, resp.
KW  - Lightning protection system
KW  - down-conductor
KW  - steel columns
KW  - metal façade
KW  - touch voltage
Y1  - 2021
SN  - 978-1-6654-2346-5
U6  - http://dx.doi.org/10.1109/ICLPandSIPDA54065.2021.9627465
N1  - 35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA), 20-26 Sept. 2021, Colombo, Sri Lanka
PB  - IEEE
ER  - 
TY  - BOOK
A1  - Pieper, Martin
T1  - Quantum mechanics: Introduction to mathematical formulation
N2  - Anyone who has always wanted to understand the hieroglyphs on Sheldon's blackboard in the TV series The Big Bang Theory or who wanted to know exactly what the fate of Schrödinger's cat is all about will find a short, descriptive introduction to the world of quantum mechanics in this essential. The text particularly focuses on the mathematical description in the Hilbert space. The content goes beyond popular scientific presentations, but is nevertheless suitable for readers without special prior knowledge thanks to the clear examples.
KW  - Quantenmechanik
KW  - Hilbert Room
KW  - Postulates
KW  - Schrödingers cat
KW  - Operators
Y1  - 2021
SN  - 978-3-658-32644-9
SN  - 978-3-658-32645-6
U6  - http://dx.doi.org/10.1007/978-3-658-32645-6
PB  - Springer
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Englhard, Markus
A1  - Weber, Tobias
A1  - Arent, Jan-Christoph
T1  - Efficiency enhancement for CFRP-Prepregautoclave manufacturing by means of simulation-assisted loading optimization
T2  - Proceedings of SAMPE Europe Conference 2021
N2  - A new method for improved autoclave loading within the restrictive framework of helicopter manufacturing is proposed. It is derived from experimental and numerical studies of the curing process and aims at optimizing tooling positions in the autoclave for fast and homogeneous heat-up. The mold positioning is based on two sets of information. The thermal properties of the molds, which can be determined via semi-empirical thermal simulation. The second information is a previously determined distribution of heat transfer coefficients inside the autoclave. Finally, an experimental proof of concept is performed to show a cycle time reduction of up to 31% using the proposed methodology.
Y1  - 2021
ER  - 
TY  - CHAP
A1  - Nikolovski, Gjorgji
A1  - Reke, Michael
A1  - Elsen, Ingo
A1  - Schiffer, Stefan
T1  - Machine learning based 3D object detection for navigation in unstructured environments
T2  - 2021 IEEE Intelligent Vehicles Symposium Workshops (IV Workshops)
N2  - In this paper we investigate the use of deep neural networks for 3D object detection in uncommon, unstructured environments such as in an open-pit mine. While neural nets are frequently used for object detection in regular autonomous driving applications, more unusual driving scenarios aside street traffic pose additional challenges. For one, the collection of appropriate data sets to train the networks is an issue. For another, testing the performance of trained networks often requires tailored integration with the particular domain as well. While there exist different solutions for these problems in regular autonomous driving, there are only very few approaches that work for special domains just as well. We address both the challenges above in this work. First, we discuss two possible ways of acquiring data for training and evaluation. That is, we evaluate a semi-automated annotation of recorded LIDAR data and we examine synthetic data generation. Using these datasets we train and test different deep neural network for the task of object detection. Second, we propose a possible integration of a ROS2 detector module for an autonomous driving platform. Finally, we present the performance of three state-of-the-art deep neural networks in the domain of 3D object detection on a synthetic dataset and a smaller one containing a characteristic object from an open-pit mine.
KW  - 3D object detection
KW  - LiDAR
KW  - autonomous driving
KW  - Deep learning
KW  - Three-dimensional displays
Y1  - 2021
SN  - 978-1-6654-7921-9
U6  - http://dx.doi.org/10.1109/IVWorkshops54471.2021.9669218
N1  - 2021 IEEE Intelligent Vehicles Symposium Workshops (IV Workshops), 11-17 July 2021,  Nagoya, Japan.
SP  - 236
EP  - 242
PB  - IEEE
ER  - 
TY  - JOUR
A1  - Engemann, Heiko
A1  - Cönen, Patrick
A1  - Dawar, Harshal
A1  - Du, Shengzhi
A1  - Kallweit, Stephan
T1  - A robot-assisted large-scale inspection of wind turbine blades in manufacturing using an autonomous mobile manipulator
JF  - Applied Sciences
N2  - Wind energy represents the dominant share of renewable energies. The rotor blades of a wind turbine are typically made from composite material, which withstands high forces during rotation. The huge dimensions of the rotor blades complicate the inspection processes in manufacturing. The automation of inspection processes has a great potential to increase the overall productivity and to create a consistent reliable database for each individual rotor blade. The focus of this paper is set on the process of rotor blade inspection automation by utilizing an autonomous mobile manipulator. The main innovations include a novel path planning strategy for zone-based navigation, which enables an intuitive right-hand or left-hand driving behavior in a shared human–robot workspace. In addition, we introduce a new method for surface orthogonal motion planning in connection with large-scale structures. An overall execution strategy controls the navigation and manipulation processes of the long-running inspection task. The implemented concepts are evaluated in simulation and applied in a real-use case including the tip of a rotor blade form.
KW  - mobile manipulation
KW  - large-scale inspection
KW  - wind turbine production
KW  - autonomous navigation
KW  - surface-orthogonal path planning
Y1  - 2021
U6  - http://dx.doi.org/10.3390/app11199271
SN  - 2076-3417
N1  - Belongs to the Special Issue "Advances in Industrial Robotics and Intelligent Systems"
VL  - 11
IS  - 19
SP  - 1
EP  - 22
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Leise, Philipp
T1  - Resilience as a concept for mastering uncertainty
T2  - Mastering Uncertainty in Mechanical Engineering
Y1  - 2021
SN  - 978-3-030-78353-2
U6  - http://dx.doi.org/10.1007/978-3-030-78354-9
N1  - Unterkapitel 6.3.1 des Kapitels "Strategies for Mastering Uncertainty"
SP  - 412
EP  - 417
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Altherr, Lena
A1  - Leise, Philipp
A1  - Pfetsch, Marc E.
A1  - Schmitt, Andreas
T1  - Optimal design of resilient technical systems on the example of water supply systems
T2  - Mastering Uncertainty in Mechanical Engineering
Y1  - 2021
SN  - 978-3-030-78356-3
N1  - Unterkapitel des Kapitels "Strategies for Mastering Uncertainty"
SP  - 429
EP  - 433
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Leise, Philipp
A1  - Altherr, Lena
T1  - Experimental evaluation of resilience metrics in a fluid system
T2  - Mastering Uncertainty in Mechanical Engineering
Y1  - 2021
SN  - 978-3-030-78356-3
N1  - Unterkapitel des Kapitels "Strategies for Mastering Uncertainty"
SP  - 442
EP  - 447
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.K.
T1  - Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard
JF  - Talanta
N2  - Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated.

In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).
KW  - qNMR
KW  - Deuterium NMR
KW  - Deuterated solvents
KW  - Standardization
Y1  - 2021
SN  - 0039-9140
U6  - http://dx.doi.org/10.1016/j.talanta.2020.121504
VL  - 222
IS  - Article number: 121504
PB  - Elsevier
ER  - 
TY  - JOUR
A1  - Burmistrova, Natalia A.
A1  - Soboleva, Polina M.
A1  - Monakhova, Yulia
T1  - Is infrared spectroscopy combined with multivariate analysis a promising tool for heparin authentication?
JF  - Journal of Pharmaceutical and Biomedical Analysis
N2  - The investigation of the possibility to determine various characteristics of powder heparin (n = 115) was carried out with infrared spectroscopy. The evaluation of heparin samples included several parameters such as purity grade, distributing company, animal source as well as heparin species (i.e. Na-heparin, Ca-heparin, and heparinoids). Multivariate analysis using principal component analysis (PCA), soft independent modelling of class analogy (SIMCA), and partial least squares – discriminant analysis (PLS-DA) were applied for the modelling of spectral data. Different pre-processing methods were applied to IR spectral data; multiplicative scatter correction (MSC) was chosen as the most relevant.

Obtained results were confirmed by nuclear magnetic resonance (NMR) spectroscopy. Good predictive ability of this approach demonstrates the potential of IR spectroscopy and chemometrics for screening of heparin quality. This approach, however, is designed as a screening tool and is not considered as a replacement for either of the methods required by USP and FDA.
KW  - IR spectroscopy
KW  - Heparin
KW  - Authenticity
KW  - Principal component analysis
KW  - Soft independent modeling of class analogy
Y1  - 2021
SN  - 0731-7085
U6  - http://dx.doi.org/10.1016/j.jpba.2020.113811
VL  - 194
IS  - Article number: 113811
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W. K.
T1  - Simplification of NMR Workflows by Standardization Using 2H Integral of Deuterated Solvent as Applied to Aloe vera Preparations
JF  - Applied Magnetic Resonance
N2  - In this study, a recently proposed NMR standardization approach by 2H integral of deuterated solvent for quantitative multicomponent analysis of complex mixtures is presented. As a proof of principle, the existing NMR routine for the analysis of Aloe vera products was modified. Instead of using absolute integrals of targeted compounds and internal standard (nicotinamide) from 1H-NMR spectra, quantification was performed based on the ratio of a particular 1H-NMR compound integral and 2H-NMR signal of deuterated solvent D2O. Validation characteristics (linearity, repeatability, accuracy) were evaluated and the results showed that the method has the same precision as internal standardization in case of multicomponent screening. Moreover, a dehydration process by freeze drying is not necessary for the new routine. Now, our NMR profiling of A. vera products needs only limited sample preparation and data processing. The new standardization methodology provides an appealing alternative for multicomponent NMR screening. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and is recommended in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00723-021-01393-4
SN  - 1613-7507
VL  - 52
IS  - 11
SP  - 1591
EP  - 1600
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Burger, René
A1  - Rumpf, Jessica
A1  - Do, Xuan Tung
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W. K.
A1  - Rehahn, Matthias
A1  - Schulze, Margit
T1  - Is NMR combined with multivariate regression applicable for the molecular weight determination of randomly cross-linked polymers such as lignin?
JF  - ACS Omega
N2  - The molecular weight properties of lignins are one of the key elements that need to be analyzed for a successful industrial application of these promising biopolymers. In this study, the use of 1H NMR as well as diffusion-ordered spectroscopy (DOSY NMR), combined with multivariate regression methods, was investigated for the determination of the molecular weight (Mw and Mn) and the polydispersity of organosolv lignins (n = 53, Miscanthus x giganteus, Paulownia tomentosa, and Silphium perfoliatum). The suitability of the models was demonstrated by cross validation (CV) as well as by an independent validation set of samples from different biomass origins (beech wood and wheat straw). CV errors of ca. 7–9 and 14–16% were achieved for all parameters with the models from the 1H NMR spectra and the DOSY NMR data, respectively. The prediction errors for the validation samples were in a similar range for the partial least squares model from the 1H NMR data and for a multiple linear regression using the DOSY NMR data. The results indicate the usefulness of NMR measurements combined with multivariate regression methods as a potential alternative to more time-consuming methods such as gel permeation chromatography.
Y1  - 2021
U6  - http://dx.doi.org/10.1021/acsomega.1c03574
SN  - 2470-1343
VL  - 6
IS  - 44
SP  - 29516
EP  - 29524
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - CHAP
A1  - Czarnecki, Christian
A1  - Hong, Chin-Gi
A1  - Schmitz, Manfred
A1  - Dietze, Christian
ED  - Urbach, Nils
ED  - Röglinger, Maximilian
ED  - Kautz, Karlheinz
ED  - Alias, Rose Alinda
ED  - Saunders, Carol
ED  - Wiener, Martin
T1  - Enabling digital transformation through cognitive robotic process automation at Deutsche Telekom Services Europe
T2  - Digitalization Cases Vol. 2 :  Mastering digital transformation for global business
N2  - Subject of this case is Deutsche Telekom Services Europe (DTSE), a service center for administrative processes. Due to the high volume of repetitive tasks (e.g., 100k manual uploads of offer documents into SAP per year), automation was identified as an important strategic target with a high management attention and commitment. DTSE has to work with various backend application systems without any possibility to change those systems. Furthermore, the complexity of administrative processes differed. When it comes to the transfer of unstructured data (e.g., offer documents) to structured data (e.g., MS Excel files), further cognitive technologies were needed.
Y1  - 2021
SN  - 978-3-030-80002-4 (Print)
SN  - 978-3-030-80003-1 (Online)
U6  - http://dx.doi.org/10.1007/978-3-030-80003-1
SP  - 123
EP  - 138
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Czarnecki, Christian
A1  - Fettke, Peter
ED  - Czarnecki, Christian
ED  - Fettke, Peter
T1  - Robotic process automation :  Positioning, structuring, and framing the work
T2  - Robotic process automation : Management, technology, applications
N2  - Robotic process automation (RPA) has attracted increasing attention in research and practice. This chapter positions, structures, and frames the topic as an introduction to this book. RPA is understood as a broad concept that comprises a variety of concrete solutions. From a management perspective RPA offers an innovative approach for realizing automation potentials, whereas from a technical perspective the implementation based on software products and the impact of artificial intelligence (AI) and machine learning (ML) are relevant. RPA is industry-independent and can be used, for example, in finance, telecommunications, and the public sector. With respect to RPA this chapter discusses definitions, related approaches, a structuring framework, a research framework, and an inside as well as outside architectural view. Furthermore, it provides an overview of the book combined with short summaries of each chapter.
KW  - Robotic process automation
KW  - management
KW  - technology
KW  - applications
KW  - research framework
Y1  - 2021
SN  - 978-3-11-067668-6 (Print)
SN  - 978-3-11-067669-3 (PDF)
SN  - 978-3-11-067677-8 (ePub)
U6  - http://dx.doi.org/10.1515/9783110676693-202
SP  - 3
EP  - 24
PB  - De Gruyter
CY  - Oldenbourg
ER  - 
TY  - CHAP
A1  - Bensberg, Frank
A1  - Auth, Gunnar
A1  - Czarnecki, Christian
ED  - Czarnecki, Christian
ED  - Fettke, Peter
T1  - Finding the perfect RPA match :  a criteria-based selection method for RPA solutions
T2  - Robotic process automation : Management, technology, applications
N2  - The benefits of robotic process automation (RPA) are highly related to the usage of commercial off-the-shelf (COTS) software products that can be easily implemented and customized by business units. But, how to find the best fitting RPA product for a specific situation that creates the expected benefits? This question is related to the general area of software evaluation and selection. In the face of more than 75 RPA products currently on the market, guidance considering those specifics is required. Therefore, this chapter proposes a criteria-based selection method specifically for RPA. The method includes a quantitative evaluation of costs and benefits as well as a qualitative utility analysis based on functional criteria. By using the visualization of financial implications (VOFI) method, an application-oriented structure is provided that opposes the total cost of ownership to the time savings times salary (TSTS). For the utility analysis a detailed list of functional criteria for RPA is offered. The whole method is based on a multi-vocal review of scientific and non-scholarly literature including publications by business practitioners, consultants, and vendors. The application of the method is illustrated by a concrete RPA example. The illustrated
structures, templates, and criteria can be directly utilized by practitioners in their real-life RPA implementations. In addition, a normative decision process for selecting RPA alternatives is proposed before the chapter closes with a discussion and outlook.
KW  - robotic process automation
KW  - business process automation
KW  - commercial offthe- shelf solutions
KW  - software evaluation
KW  - software selection
Y1  - 2021
SN  - 978-3-11-067677-8
SN  - 978-3-11-067669-3
SN  - 9783110676686
U6  - http://dx.doi.org/10.1515/9783110676693-201
SP  - 47
EP  - 75
PB  - De Gruyter
CY  - Oldenbourg
ER  - 
TY  - CHAP
A1  - Croon, Philipp
A1  - Czarnecki, Christian
ED  - Czarnecki, Christian
ED  - Fettke, Peter
T1  - Liability for loss or damages caused by RPA
T2  - Robotic process automation : Management, technology, applications
N2  - Intelligent autonomous software robots replacing human activities and performing administrative processes are reality in today’s corporate world. This includes, for example, decisions about invoice payments, identification of customers for a marketing campaign, and answering customer complaints. What happens if such a software robot causes a damage? Due to the complete absence of human activities, the question is not trivial. It could even happen that no one is liable for a damage towards a third party, which could create an uncalculatable legal risk for business partners. Furthermore, the implementation and operation of those software robots involves various stakeholders, which result in the unsolvable endeavor of identifying the originator of a damage. Overall it is advisable to all involved parties to carefully consider the legal situation. This chapter discusses the liability of software robots from an interdisciplinary perspective. Based on different technical scenarios the legal aspects of liability are discussed.
KW  - robotic process automation
KW  - artificial intelligence
KW  - liability
KW  - culpability
Y1  - 2021
SN  - 9783110676778
SN  - 9783110676693
SN  - 9783110676686
U6  - http://dx.doi.org/10.1515/9783110676693-202
SP  - 135
EP  - 151
PB  - De Gruyter
CY  - Oldenbourg
ER  - 
TY  - CHAP
A1  - Ritschel, Konstantin
A1  - Stenzel, Adina
A1  - Czarnecki, Christian
A1  - Hong, Chin-Gi
ED  - Gesellschaft für Informatik e.V. (GI), 
T1  - Realizing robotic process automation potentials: an architectural perspective on a real-life implementation case
T2  - GI Edition Proceedings Band 314 "INFORMATIK 2021" Computer Science & Sustainability
N2  - The initial idea of Robotic Process Automation (RPA) is the automation of business processes through a simple emulation of user input and output by software robots. Hence, it can be assumed that no changes of the used software systems and existing Enterprise Architecture (EA) is
required. In this short, practical paper we discuss this assumption based on a real-life implementation project. We show that a successful RPA implementation might require architectural work during analysis, implementation, and migration. As practical paper we focus on exemplary lessons-learned and new questions related to RPA and EA.
KW  - Robotic Process Automation
KW  - Enterprise Architecture
KW  - Implementation Case
Y1  - 2021
SN  - 9783885797081
SN  - 1617-5468
N1  - INFORMATIK 2021 – 51. Jahrestagung der Gesellschaft für Informatik, 27. September – 01. Oktober 2021 / Virtuell, Berlin.
https://informatik2021.gi.de/
SP  - 1303
EP  - 1311
PB  - Köllen
CY  - Bonn
ER  - 
TY  - JOUR
A1  - Akimbekov, Nuraly
A1  - Digel, Ilya
A1  - Abdieva, Gulzhamal
A1  - Ualieva, Perizat
A1  - Tastambek, Kuanysh
T1  - Lignite biosolubilization and bioconversion by Bacillus sp.: the collation of analytical data
JF  - Biofuels
N2  - The vast metabolic potential of microbes in brown coal (lignite) processing and utilization can greatly contribute to innovative approaches to sustainable production of high-value products from coal. In this study, the multi-faceted and complex coal biosolubilization process by Bacillus sp. RKB 7 isolate from the Kazakhstan coal-mining soil is reported, and the derived products are characterized. Lignite solubilization tests performed for surface and suspension cultures testify to the formation of numerous soluble lignite-derived substances. Almost 24% of crude lignite (5% w/v) was solubilized within 14 days under slightly alkaline conditions (pH 8.2). FTIR analysis revealed various functional groups in the obtained biosolubilization products. Analyses of the lignite-derived humic products by UV-Vis and fluorescence spectrometry as well as elemental analysis yielded compatible results indicating the emerging products had a lower molecular weight and degree of aromaticity. Furthermore, XRD and SEM analyses were used to evaluate the biosolubilization processes from mineralogical and microscopic points of view. The findings not only contribute to a deeper understanding of microbe–mineral interactions in coal environments, but also contribute to knowledge of coal biosolubilization and bioconversion with regard to sustainable production of humic substances. The detailed and comprehensive analyses demonstrate the huge biotechnological potential of Bacillus sp. for agricultural productivity and environmental health.
KW  - humic acid
KW  - Bacillus sp
KW  - lignite
KW  - Biosolubilization
Y1  - 2021
SN  - 1759-7277
VL  - 12
IS  - 3
SP  - 247
EP  - 258
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Köhler, Klemens
A1  - Röpke, René
A1  - Wolf, Martin
T1  - Through a mirror darkly – On the obscurity of teaching goals in game-based learning in IT security
JF  - ISAGA 2019: Simulation Gaming Through Times and Disciplines
N2  - Teachers and instructors use very specific language communicating teaching goals. The most widely used frameworks of common reference are the Bloom’s Taxonomy and the Revised Bloom’s Taxonomy. The latter provides distinction of 209 different teaching goals which are connected to methods. In Competence Developing Games (CDGs - serious games to convey knowledge) and in IT security education, a two- or three level typology exists, reducing possible learning outcomes to awareness, training, and education. This study explores whether this much simpler framework succeeds in achieving the same range of learning outcomes. Method wise a keyword analysis was conducted. The results were threefold: 1. The words used to describe teaching goals in CDGs on IT security education do not reflect the whole range of learning outcomes. 2. The word choice is nevertheless different from common language, indicating an intentional use of language. 3. IT security CDGs use different sets of terms to describe learning outcomes, depending on whether they are awareness, training, or education games. The interpretation of the findings is that the reduction to just three types of CDGs reduces the capacity to communicate and think about learning outcomes and consequently reduces the outcomes that are intentionally achieved.
KW  - IT security education
KW  - Competence Developing Games
KW  - Game-based learning
KW  - Keyword analysis
KW  - Bloom’s Taxonomy
Y1  - 2021
U6  - http://dx.doi.org/10.1007/978-3-030-72132-9_6
N1  - ISAGA 2019 - International Simulation and Gaming Association Conference. 26-30 August 2019. Warsaw, Poland.

Part of the Lecture Notes in Computer Science book series (LNCS, volume 11988)
SP  - 61
EP  - 73
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020
JF  - physica status solidi (a) applications and materials science
N2  - The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.
KW  - bioburdens
KW  - sterility tests
KW  - sterilization efficacy
KW  - sterilization methods
KW  - validation methods
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000732
SN  - 1862-6319
N1  - Corresponding author: Michael J. Schöning
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - THES
A1  - Bayer, Robin
T1  - Development of a novel in-vitro vascular model for determination of physiological and pathophysiological mechanobiology
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:38-362212
N1  - Dissertation, Universität zu Köln, 2021
PB  - Universität zu Köln
CY  - Köln
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Drinic, Aleksander
A1  - Iken, Heiko
A1  - Kröger, Nadja
A1  - Zinser, Max
A1  - Smeets, Ralf
A1  - Köpf, Marius
A1  - Kopp, Alexander
A1  - Schöning, Michael Josef
T1  - Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk
JF  - Biosensors and Bioelectronics
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.bios.2021.113204
SN  - 0956-5663
VL  - 183
IS  - Art. 113204
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - El Moussaoui, Noureddine
A1  - Kassmi, Khalil
A1  - Alexopoulos, Spiros
A1  - Schwarzer, Klemens
A1  - Chayeb, Hamid
A1  - Bachiri, Najib
T1  - Simulation studies on a new innovative design of a hybrid solar distiller MSDH alimented with a thermal and photovoltaic energy
T2  - Materialstoday: Proceedings
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.matpr.2021.03.115
SN  - 2214-7853
ER  - 
TY  - JOUR
A1  - Maurischat, Andreas
T1  - Algebraic independence of the Carlitz period and its hyperderivatives
KW  - Drinfeld modules
KW  - t-modules
KW  - Transcendence
KW  - Hyperdifferentials
Y1  - 2021
N1  - Zweitveröffentlichung.
Verlagsveröffentlichung: https://doi.org/10.1016/j.jnt.2022.01.006
SP  - 1
EP  - 12
ER  - 
TY  - JOUR
A1  - Wert, Stefan
A1  - Iken, Heiko
A1  - Schöning, Michael Josef
A1  - Matysik, Frank-Michael
T1  - Development of a temperature‐pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy
JF  - Electroanalysis
N2  - Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.
Y1  - 2021
U6  - http://dx.doi.org/10.1002/elan.202100089
SN  - 1521-4109
IS  - Early View
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Lowis, Carsten
A1  - Ferguson, Simon
A1  - Paulßen, Elisabeth
A1  - Hoehr, Cornelia
T1  - Improved Sc-44 production in a siphon-style liquid target on a medical cyclotron
JF  - Applied Radiation and Isotopes
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.apradiso.2021.109675
SN  - 0969-8043
VL  - 172
IS  - Art. 109675
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Waldvogel, Janice
A1  - Ritzmann, Ramona
A1  - Freyler, Kathrin
A1  - Helm, Michael
A1  - Monti, Elena
A1  - Albracht, Kirsten
A1  - Stäudle, Benjamin
A1  - Gollhofer, Albert
A1  - Narici, Marco
T1  - The Anticipation of Gravity in Human Ballistic Movement
JF  - Frontiers in Physiology
N2  - Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fphys.2021.614060
SN  - 1664-042X
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Bergs, Michel
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W.
A1  - Konow, Christopher
A1  - Völkering, Georg
A1  - Pude, Ralf
A1  - Schulze, Margit
T1  - Lignins isolated via catalyst-free organosolv pulping from Miscanthus x giganteus, M. sinensis, M. robustus and M. nagara: a comparative study
JF  - Molecules
N2  - As a low-input crop, Miscanthus offers numerous advantages that, in addition to agricultural applications, permits its exploitation for energy, fuel, and material production. Depending on the Miscanthus genotype, season, and harvest time as well as plant component (leaf versus stem), correlations between structure and properties of the corresponding isolated lignins differ. Here, a comparative study is presented between lignins isolated from M. x giganteus, M. sinensis, M. robustus and M. nagara using a catalyst-free organosolv pulping process. The lignins from different plant constituents are also compared regarding their similarities and differences regarding monolignol ratio and important linkages. Results showed that the plant genotype has the weakest influence on monolignol content and interunit linkages. In contrast, structural differences are more significant among lignins of different harvest time and/or season. Analyses were performed using fast and simple methods such as nuclear magnetic resonance (NMR) spectroscopy. Data was assigned to four different linkages (A: β-O-4 linkage, B: phenylcoumaran, C: resinol, D: β-unsaturated ester). In conclusion, A content is particularly high in leaf-derived lignins at just under 70% and significantly lower in stem and mixture lignins at around 60% and almost 65%. The second most common linkage pattern is D in all isolated lignins, the proportion of which is also strongly dependent on the crop portion. Both stem and mixture lignins, have a relatively high share of approximately 20% or more (maximum is M. sinensis Sin2 with over 30%). In the leaf-derived lignins, the proportions are significantly lower on average. Stem samples should be chosen if the highest possible lignin content is desired, specifically from the M. x giganteus genotype, which revealed lignin contents up to 27%. Due to the better frost resistance and higher stem stability, M. nagara offers some advantages compared to M. x giganteus. Miscanthus crops are shown to be very attractive lignocellulose feedstock (LCF) for second generation biorefineries and lignin generation in Europe.
Y1  - 2021
U6  - http://dx.doi.org/10.3390/molecules26040842
SN  - 1420-3049
N1  - Special Issue Lignin – A Natural Resource with Huge Potential https://www.mdpi.com/journal/molecules/special_issues/lignin_natural
VL  - 26
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
T1  - Light-addressable potentiometric sensors (LAPS) for cell monitoring and biosensing
JF  - Current Opinion in Electrochemistry
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.coelec.2021.100727
SN  - 2451-9103
IS  - In Press, Journal Pre-proof
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bohndick, Carla
A1  - Bosse, Elke
A1  - Jänsch, Vanessa K.
A1  - Barnat, Miriam
T1  - How different diversity factors affect the perception of first-year requirements in higher education
JF  - Frontline Learning Research
N2  - In the light of growing university entry rates, higher education institutions not only serve larger numbers of students, but also seek to meet first-year students’ ever more diverse needs. Yet to inform universities how to support the transition to higher education, research only offers limited insights. Current studies tend to either focus on the individual factors that affect student success or they highlight students’ social background and their educational biography in order to examine the achievement of selected, non-traditional groups of students. Both lines of research appear to lack integration and often fail to take organisational diversity into account, such as different types of higher education institutions or degree programmes. For a more comprehensive understanding of student diversity, the present study includes individual, social and organisational factors. To gain insights into their role for the transition to higher education, we examine how the different factors affect the students’ perception of the formal and informal requirements of the first year as more or less difficult to cope with. As the perceived requirements result from both the characteristics of the students and the institutional context, they allow to investigate transition at the interface of the micro and the meso level of higher education. Latent profile analyses revealed that there are no profiles with complex patterns of perception of the first-year requirements, but the identified groups rather differ in the overall level of perceived challenges. Moreover, SEM indicates that the differences in the perception largely depend on the individual factors self-efficacy and volition.
Y1  - 2021
U6  - http://dx.doi.org/10.14786/flr.v9i2.667
SN  - 2295-3159
VL  - 9
IS  - 2
SP  - 78
EP  - 95
PB  - EARLI
ER  - 
TY  - JOUR
A1  - Monakhova, Yulia
A1  - Diehl, Bernd W. K.
T1  - A step towards optimization of the qNMR workflow: proficiency testing exercise at an GxP-accredited laboratory
JF  - Applied Magnetic Resonance
N2  - Quantitative nuclear magnetic resonance (qNMR) is considered as a powerful tool for multicomponent mixture analysis as well as for the purity determination of single compounds. Special attention is currently paid to the training of operators and study directors involved in qNMR testing. To assure that only qualified personnel are used for sample preparation at our GxP-accredited laboratory, weighing test was proposed. Sixteen participants performed six-fold weighing of the binary mixture of dibutylated hydroxytoluene (BHT) and 1,2,4,5-tetrachloro-3-nitrobenzene (TCNB). To evaluate the quality of data analysis, all spectra were evaluated manually by a qNMR expert and using in-house developed automated routine. The results revealed that mean values are comparable and both evaluation approaches are free of systematic error. However, automated evaluation resulted in an approximately 20% increase in precision. The same findings were revealed for qNMR analysis of 32 compounds used in pharmaceutical industry. Weighing test by six-fold determination in binary mixtures and automated qNMR methodology can be recommended as efficient tools for evaluating staff proficiency. The automated qNMR method significantly increases throughput and precision of qNMR for routine measurements and extends application scope of qNMR.
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00723-021-01324-3
SN  - 1613-7507
N1  - Corresponding author: Yulia Monakhova
VL  - 52
SP  - 581
EP  - 593
PB  - Springer Nature
CY  - Wien
ER  - 
TY  - JOUR
A1  - Becht, Alexander
A1  - Schollmayer, Curd
A1  - Monakhova, Yulia
A1  - Holzgrabe, Ulrike
T1  - Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis
JF  - Analytical and Bioanalytical Chemistry
N2  - Most drugs are no longer produced in their own countries by the pharmaceutical companies, but by contract manufacturers or at manufacturing sites in countries that can produce more cheaply. This not only makes it difficult to trace them back but also leaves room for criminal organizations to fake them unnoticed. For these reasons, it is becoming increasingly difficult to determine the exact origin of drugs. The goal of this work was to investigate how exactly this is possible by using different spectroscopic methods like nuclear magnetic resonance and near- and mid-infrared spectroscopy in combination with multivariate data analysis. As an example, 56 out of 64 different paracetamol preparations, collected from 19 countries around the world, were chosen to investigate whether it is possible to determine the pharmaceutical company, manufacturing site, or country of origin. By means of suitable pre-processing of the spectra and the different information contained in each method, principal component analysis was able to evaluate manufacturing relationships between individual companies and to differentiate between production sites or formulations. Linear discriminant analysis showed different results depending on the spectral method and purpose. For all spectroscopic methods, it was found that the classification of the preparations to their manufacturer achieves better results than the classification to their pharmaceutical company. The best results were obtained with nuclear magnetic resonance and near-infrared data, with 94.6%/99.6% and 98.7/100% of the spectra of the preparations correctly assigned to their pharmaceutical company or manufacturer.
KW  - IR
KW  - Manufacturer
KW  - Linear discriminant analysis
KW  - Principal component analysis
Y1  - 2021
U6  - http://dx.doi.org/10.1007/s00216-021-03249-z
SN  - 1618-2650
VL  - 413
SP  - 3107
EP  - 3118
PB  - Springer Nature
ER  - 
TY  - CHAP
A1  - Ferrein, Alexander
A1  - Meeßen, Marcus
A1  - Limpert, Nicolas
A1  - Schiffer, Stefan
ED  - Lepuschitz, Wilfried
T1  - Compiling ROS Schooling Curricula via Contentual Taxonomies
T2  - Robotics in Education
Y1  - 2021
SN  - 978-3-030-67411-3
U6  - http://dx.doi.org/10.1007/978-3-030-67411-3_5
N1  - RiE: International Conference on Robotics in Education (RiE);
Advances in Intelligent Systems and Computing book series (AISC, volume 1316)
SP  - 49
EP  - 60
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Götten, Falk
A1  - Havermann, Marc
A1  - Braun, Carsten
A1  - Marino, Matthew
A1  - Bil, Cees
T1  - Aerodynamic Investigations of UAV Sensor Turrets - A Combined Wind-tunnel and CFD Approach
JF  - SciTech 2021, AIAA SciTech Forum, online, WW, Jan 11-15, 2021
Y1  - 2021
U6  - http://dx.doi.org/10.2514/6.2021-1535
SP  - 1
EP  - 12
PB  - AIAA
CY  - Reston, Va.
ER  - 
TY  - JOUR
A1  - Hugenroth, Kristin
A1  - Neidlin, Michael
A1  - Engelmann, Ulrich M.
A1  - Kaufmann, Tim A. S.
A1  - Steinseifer, Ulrich
A1  - Heilmann, Torsten
T1  - Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk‐Reduced Placement: an In Silico Proof‐of‐Concept
JF  - Artificial Organs
Y1  - 2021
U6  - http://dx.doi.org/10.1111/aor.13964
SN  - 1525-1594
IS  - Accepted Article
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Harzheim, Thomas
A1  - Mühmel, Marc
A1  - Heuermann, Holger
T1  - A SFCW harmonic radar system for maritime search and rescue using passive and active tags
JF  - International Journal of Microwave and Wireless Technologies
N2  - This paper introduces a new maritime search and rescue system based on S-band illumination harmonic radar (HR). Passive and active tags have been developed and tested while attached to life jackets and a small boat. In this demonstration test carried out on the Baltic Sea, the system was able to detect and range the active tags up to a distance of 5800 m using an illumination signal transmit-power of 100 W. Special attention is given to the development, performance, and conceptual differences between passive and active tags used in the system. Guidelines for achieving a high HR dynamic range, including a system components description, are given and a comparison with other HR systems is performed. System integration with a commercial maritime X-band navigation radar is shown to demonstrate a solution for rapid search and rescue response and quick localization.
KW  - Radar
KW  - microwave measurements
KW  - harmonic radar
KW  - harmonic radar tags
KW  - nonlinear VNA measurements
Y1  - 2021
U6  - http://dx.doi.org/10.1017/S1759078721000520
VL  - 13
IS  - Special Issue 7
SP  - 691
EP  - 707
PB  - Cambridge University Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Nacov, Julia
A1  - Kammerlohr, Sandra
A1  - Staat, Manfred
A1  - Buess, Eduard
A1  - Leschinger, Tim
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Intratendinous Strain Variations of the Supraspinatus Tendon Depending on Repair Technique: A Biomechanical Analysis Regarding the Cause of Medial Cuff Failure
JF  - The American Journal of Sports Medicine
Y1  - 2021
U6  - http://dx.doi.org/10.1177/03635465211006138
SN  - 1552-3365
SN  - 0363-5465
VL  - 49
IS  - 7
SP  - 1847
EP  - 1853
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Neumaier, Felix
A1  - Kotliar, Konstantin
A1  - Haeren, Roel Hubert Louis
A1  - Temel, Yasin
A1  - Lüke, Jan Niklas
A1  - Seyam, Osama
A1  - Lindauer, Ute
A1  - Clusmann, Hans
A1  - Hescheler, Jürgen
A1  - Schubert, Gerrit Alexander
A1  - Schneider, Toni
A1  - Albanna, Walid
T1  - Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA)
JF  - Frontiers in Neurology
Y1  - 2021
U6  - http://dx.doi.org/10.3389/fneur.2021.659890
VL  - 12
SP  - 1
EP  - 11
PB  - Frontiers
ER  - 
TY  - JOUR
A1  - Givanoudi, Stella
A1  - Cornelis, Peter
A1  - Rasschaert, Geertrui
A1  - Wackers, Gideon
A1  - Iken, Heiko
A1  - Rolka, David
A1  - Yongabi, Derick
A1  - Robbens, Johan
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source
JF  - Sensors and Actuators B: Chemical
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.snb.2021.129484
SN  - 0925-4005
IS  - In Press, Journal Pre-proof
SP  - Article 129484
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Münstermann, Felix
A1  - Nork, Jasmina
A1  - Molinnus, Denise
A1  - Muschallik, Lukas
A1  - Bongaerts, Johannes
A1  - Wagner, Torsten
A1  - Keusgen, Michael
A1  - Siegert, Petra
A1  - Schöning, Michael Josef
T1  - Capacitive field‐effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths
JF  - physica status solidi (a) applications and materials science
N2  - An acetoin biosensor based on a capacitive electrolyte–insulator–semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance–voltage, and constant capacitance methods, respectively.
KW  - acetoin
KW  - acetoin reductase
KW  - alcoholic beverages
KW  - biosensors
KW  - capacitive field-effect sensors
Y1  - 2021
U6  - http://dx.doi.org/10.1002/pssa.202000765
SN  - 1862-6319
VL  - 218
IS  - 13
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Heuermann, Holger
A1  - Harzheim, Thomas
A1  - Mühmel, Marc
T1  - A maritime harmonic radar search and rescue system using passive and active tags
T2  - 2020 17th European Radar Conference (EuRAD)
KW  - Harmonic Radar
KW  - Rescue System
KW  - Frequency Doubler
KW  - Transponder
KW  - Tag
Y1  - 2021
SN  - 978-2-87487-061-3
U6  - http://dx.doi.org/10.1109/EuRAD48048.2021.00030
N1  - Proceedings of the 17th European Radar Conference, 
13th - 15th January 2021, Utrecht, Netherlands
SP  - 73
EP  - 76
PB  - IEEE
ER  - 
TY  - CHAP
A1  - Funke, Harald
A1  - Beckmann, Nils
A1  - Keinz, Jan
A1  - Horikawa, Atsushi
T1  - 30 years of dry low NOx micromix combustor research for hydrogen-rich fuels: an overview of past and present activities
T2  - Proceedings of the ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition, September 21–25, 2020, Virtual, Online. Vol.: 4B: Combustion, Fuels, and Emissions
KW  - Micromix
KW  - Hydrogen
KW  - Fuel-flexibility
KW  - NOx
KW  - Emissions
Y1  - 2021
SN  - 978-0-7918-8413-3
U6  - http://dx.doi.org/10.1115/GT2020-16328
N1  - Paper No. GT2020-16328, V04BT04A069
PB  - American Society of Mechanical Engineers (ASME)
ER  - 
TY  - CHAP
A1  - Schulte, Maximilian
A1  - Eggert, Mathias
T1  - Predicting hourly bitcoin prices based on long short-term memory neural networks
T2  - Proceedings of the International Conference on Wirtschaftsinformatik (WI) 2021
N2  - Bitcoin is a cryptocurrency and is considered a high-risk asset
class whose price changes are difficult to predict. Current research focusses
on daily price movements with a limited number of predictors. The paper at
hand aims at identifying measurable indicators for Bitcoin price movement s
and the development of a suitable forecasting model for hourly changes. The
paper provides three research contributions. First, a set of significant
indicators for predicting the Bitcoin price is identified. Second, the results of
a trained Long Short-term Memory (LSTM) neural network that predicts
price changes on an hourly basis is presented and compared with other
algorithms. Third, the results foster discussions of the applicability of neural
nets for stock price predictions. In total, 47 input features for a period of
over 10 months could be retrieved to train a neural net that predicts the
Bitcoin price movements with an error rate of 3.52 %.
Y1  - 2021
N1  - 16th International Conference on Wirtschaftsinformatik,
March 2021, Essen, Germany
ER  - 
TY  - JOUR
A1  - Erpicum, Sebastien
A1  - Crookston, Brian M.
A1  - Bombardelli, Fabian
A1  - Bung, Daniel B.
A1  - Felder, Stefan
A1  - Mulligan, Sean
A1  - Oertel, Mario
A1  - Palermo, Michele
T1  - Hydraulic structures engineering: An evolving science in a changing world
JF  - Wires Water
Y1  - 2021
U6  - http://dx.doi.org/10.1002/wat2.1505
SN  - 2049-1948
VL  - 8
IS  - 2
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Severin, Robin
A1  - Keusgen, Michael
A1  - Wege, Christian
A1  - Schöning, Michael Josef
T1  - Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles
JF  - Micromachines
N2  - Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles.
KW  - capacitive field-effect sensor
KW  - plant virus detection
KW  - tobacco mosaic virus (TMV)
KW  - TMV adsorption
KW  - Ta₂O₅ gate
Y1  - 2021
U6  - http://dx.doi.org/10.3390/mi12010057
VL  - 12
IS  - 1
PB  - MDPI
CY  - Basel
ER  -