TY - CHAP A1 - Reisgen, Uwe A1 - Schoene, Jens A1 - Schleser, Markus A1 - Jerabek, Jakub A1 - Keil, Allessandra ED - Brameshuber, Wolfgang T1 - Theoretical and experimental investigations on textile-reinforced concrete spalling behavior T2 - Textile reinforced concrete : 2nd ICTRC : International RILEM Conference on Material Science : Aachen Germany, September 6 - 8, 2010. Vol. 1. (RILEM Proceedings PRO ; 75) Y1 - 2010 SN - 978-2-35158-106-3 SP - 153 EP - 162 PB - RILEM Publ. CY - Bagneux ER - TY - CHAP A1 - Schoene, Jens A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Jerabek, Jakub A1 - Chudoba, Rostislav ED - Fisher, Gregor T1 - Theoretical and experimental investigations on textile-reinforced concrete spalling behavior T2 - 8th International PhD Symposium in Civil Engineering : Lyngby, June 20-23, 2010 : proceedings Y1 - 2010 SN - 9788778773012 SP - 383 EP - 388 PB - Technical University of Denmark, Dept. of Civil Engineering CY - Lyngby ER - TY - CHAP A1 - Goldbach, Daniel A1 - Ament, Christoph ED - Scharff, Peter T1 - Stabilized reversing with vehicle trailer combinations T2 - Crossing borders within the ABC : automation, biomedical engineering and computer science; proceedings; 55. IWK Internationales Wissenschaftliches Kolloquium; 13 - 17 September 2010, Ilmenau Y1 - 2010 SN - 978-3-938843-53-6 SP - 352 EP - 357 PB - Verl. ISLE CY - Ilmenau ER - TY - CHAP A1 - Bung, Daniel B. A1 - Oertel, M. A1 - Schlenkhoff, A. A1 - Schlurmann, Torsten ED - Obrusnik, Ivan T1 - Flash flood awareness and prevention in Germany T2 - Early warning for flash floods : international workshop, Praha 2011 : workshop proceedings Y1 - 2010 SN - 978-80-86690-91-9 SP - 34 EP - 40 ER - TY - CHAP A1 - Heinz, G. A1 - Oertel, Mario A1 - Bung, Daniel B. ED - Janssen, Robert T1 - Investigations on a cooling water system for a gas tubine facility concerning air vortexes and sediment transport T2 - Hydraulic structures: useful water harvesting systems or relics? : Third International Junior Researcher and Engineer Workshop on Hydraulic Structures (IJREWHS'10) : Edinburgh, Scotland, U.K., 2-3 May 2010 Y1 - 2010 SN - 9781742720159 SP - 109 EP - 116 PB - School of Civil Engineering, The University of Queensland CY - Brisbane ER - TY - CHAP A1 - Kerpen, N. B. A1 - Bung, Daniel B. A1 - Schlurmann, Torsten ED - Janssen, Robert T1 - Physical model investigations of ships passing through a lock T2 - Hydraulic structures: useful water harvesting systems or relics? : Third International Junior Researcher and Engineer Workshop on Hydraulic Structures (IJREWHS'10) : Edinburgh, Scotland, U.K., 2-3 May 2010 Y1 - 2010 SN - 9781742720159 SP - 93 EP - 100 PB - School of Civil Engineeering, The University of Queensland CY - Brisbane ER - TY - CHAP A1 - Bung, Daniel B. A1 - Schlenkhoff, Andreas T1 - Self-aerated skimming flow on embankment stepped spillways : the effect of additional micro-roughness on energy dissipation and oxygen transfer T2 - Proceedings from first IAHR European congress : May 2010, Edinburgh Y1 - 2010 SN - 9780956595102 SP - Artikelkennnummer HSIIId PB - Heriot-Watt University, School of the Built Environment CY - Edinburgh ER - TY - CHAP A1 - Kerpen, N. B. A1 - Bung, Daniel B. A1 - Schlurmann, Torsten T1 - Physical model investigations of pressure distributions next to ships passing through a lock T2 - 5th Chinese-German Joint Symposium on Hydraulic and Ocean Engineering : CG JOINT 2010 Y1 - 2010 SN - 978-7-5618-3671-2 SP - 514 EP - 519 PB - Univ. Press CY - Tianjin ER - TY - CHAP A1 - Bung, Daniel B. T1 - A comparative study of self-aerated stepped spillway and smooth invert chute flow: the effect of step-induced macro roughness T2 - 5th Chinese-German Joint Symposium on Hydraulic and Ocean Engineering : CG JOINT 2010 Y1 - 2010 SN - 978-7-5618-3671-2 SP - 451 EP - 456 PB - Univ. Press CY - Tianjin ER - TY - CHAP A1 - Feldhusen, Jörg A1 - Brezing, Alexander Nikolaus A1 - Pütz, Claus A1 - Wählisch, Georg T1 - Multi-system CAD-teaching in large classes T2 - When design education and design research meet : proceedings of the 12th International Conference on Engineering and Product Design Education, Norwegian University of Science and Technology (NTNU) Trondheim, Norway, 2nd - 3rd September 2010 ; [E&PDE] Y1 - 2010 SN - 978-1-904670-19-3 SP - 204 EP - 209 PB - Design Society CY - Glasgow ER - TY - CHAP A1 - Gligorevic, Snjezana A1 - Pulini, Paola T1 - Simplified airport surface channel model based on the WSSUS assumption T2 - 2010 Integrated Communications, Navigation and Surveillance Conference (ICNS 2010) : Herndon, Virginia, USA, 11 - 13 May 2010 Y1 - 2010 SN - 978-1-4244-7457-8 SN - 2155-4943 SP - F2-1 EP - F2-11 ER - TY - CHAP A1 - Schnell, Michael A1 - Franzen, Nico A1 - Gligorevic, Snjezana T1 - L-DACS1 laboratory demonstrator development and compatibility measurement set-up T2 - IEEE/AIAA 29th Digital Avionics Systems Conference (DASC) : 3 - 7 Oct. 2010, Salt Lake City, Utah Y1 - 2010 SN - 9781424466160 ; 9781424466184 SP - 3E3-1 EP - 3E3-11 ER - TY - CHAP A1 - Walter, Michael A1 - Gligorevic, Snjezana A1 - Detert, Thorben A1 - Schnell, Michael T1 - UHF/VHF air-to-air propagation measurements T2 - Proceedings of the Fourth European Conference on Antennas and Propagation (EuCAP) : 12 - 16 April 2010, Barcelona, Spain Y1 - 2010 SN - 978-1-4244-6431-9 ; 978-84-7653-472-4 SP - 1 EP - 5 ER - TY - JOUR A1 - Ribitsch, D. A1 - Karl, W. A1 - Birner-Gruenberger, R. A1 - Gruber, K. A1 - Eiteljoerg, I. A1 - Remler, P. A1 - Wieland, S. A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Schwab, H. T1 - C-terminal truncation of a metagenome-derived detergent protease for effective expression in E. coli JF - Journal of biotechnology N2 - Recently, a new alkaline protease named HP70 showing highest homology to extracellular serine proteases of Stenotrophomonas maltophilia and Xanthomonas campestris was found in the course of a metagenome screening for detergent proteases (Niehaus et al., submitted for publication). Attempts to efficiently express the enzyme in common expression hosts had failed. This study reports on the realization of overexpression in Escherichia coli after structural modification of HP70. Modelling of HP70 resulted in a two-domain structure, comprising the catalytic domain and a C-terminal domain which includes about 100 amino acids. On the basis of the modelled structure the enzyme was truncated by deletion of most of the C-terminal domain yielding HP70-C477. This structural modification allowed effective expression of active enzyme using E. coli BL21-Gold as the host. Specific activity of HP70-C477 determined with suc-l-Ala-l-Ala-l-Pro-l-Phe-p-nitroanilide as the substrate was 30 ± 5 U/mg compared to 8 ± 1 U/mg of the native enzyme. HP70-C477 was most active at 40 °C and pH 7–11; these conditions are prerequisite for a potential application as detergent enzyme. Determination of kinetic parameters at 40 °C and pH = 9.5 resulted in KM = 0.23 ± 0.01 mM and kcat = 167.5 ± 3.6 s⁻¹. MS-analysis of peptide fragments obtained from incubation of HP70 and HP70-C477 with insulin B indicated that the C-terminal domain influences the cleavage preferences of the enzyme. Washing experiments confirmed the high potential of HP70-C477 as detergent protease. Y1 - 2010 U6 - http://dx.doi.org/10.1016/j.jbiotec.2010.09.947 SN - 1873-4863 (E-Journal); 0168-1656 (Print) VL - 150 IS - 3 SP - 408 EP - 416 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Pfaff, Raphael A1 - Larkowski, Tomasz A1 - Burnham, Keith J. T1 - An approach to adaptive control in the behavioural framework T2 - UKACC International Conference on Control 2010 (CONTROL 2010) : Coventry, United Kingdom, 7 - 10 September 2010 ; Vol. 2. (IET seminar digest ; 2010/004) Y1 - 2010 SN - 978-1-62748-119-9 SP - 833 EP - 838 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Magnor, D. A1 - Soltau, N. A1 - Bragard, Michael A1 - Schmiegel, A. A1 - De Doncker, R. W. A1 - Sauer, D. U. ED - de Santi, Giovanni Frederigo T1 - Analysis of the model dynamics for the battery and battery converter in a grid-connected 5 kW photovoltaic system T2 - Proceedings / 25th European Photovoltaic Solar Energy Conference and Exhibition ; 5th World Conference on Photovoltaic Energy Conversion ; Feria Valencia, Convention & Exhibition Centre, Valencia, Spain, conference 6 - 10 September 2010, exhibition 6 - 9 September 2010 ; Joint World Conference of: 25th European Photovoltic Solar Energy Conference and Exhibition, 36th US IEEE Photovoltaic Specialists Conference, 20th Asia/Pacific PV Science and Engineering Conference Y1 - 2010 SN - 3-936338-26-4 (DVD-ROM) N1 - EU PVSEC WCPEC PB - WIP Renewable Energies CY - [München] ER - TY - CHAP A1 - Bragard, Michael A1 - Soltau, N. A1 - De Doncker, R. W. A1 - Schmiegel, A. T1 - Design and implementation of a 5 kW photovoltaic system with li-ion battery and additional DC-DC converter T2 - 2010 IEEE Energy Conversion Congress and Exposition (ECCE 2010) : Atlanta, Georgia, USA, 12 - 16 September 2010 / [sponsored by the IEEE Power Electronics and Industry Applications Societies] Y1 - 2010 SN - 978-1-4244-5286-6 (Print) SN - 978-1-4244-5287-3 (Online) U6 - http://dx.doi.org/10.1109/ECCE.2010.5618220 SP - 2944 EP - 2949 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Bragard, Michael A1 - Conrad, M. A1 - De Doncker, R. W. T1 - The integrated emitter turn-off thyristor (IETO) : an innovative thyristor based high power semiconductor device using MOS assisted turn-off T2 - 2010 IEEE Energy Conversion Congress and Exposition (ECCE 2010) : Atlanta, Georgia, USA, 12 - 16 September 2010 / [sponsored by the IEEE Power Electronics and Industry Applications Societies] Y1 - 2010 SN - 978-1-4244-5286-6 (Print) SN - 978-1-4244-5287-3 (Online) U6 - http://dx.doi.org/10.1109/ECCE.2010.5618410 SP - 4551 EP - 4557 PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Beging, Stefan A1 - Poghossian, Arshak A1 - Mlynek, D. A1 - Hataihimakul, S. A1 - Pedraza, A. A1 - Dhawan, S. A1 - Laube, N. A1 - Kleinen, L. A1 - Baldsiefen, G. A1 - Busch, H. A1 - Schöning, Michael Josef T1 - Ion-selective sensors for the determination of the risk of urinary stone formation T2 - Micro- and Nanosystems in biochemical diagnosis : Principles and applications Y1 - 2010 SP - 74 EP - 80 CY - Warsaw ER - TY - CHAP A1 - Schürmann, Volker A1 - Leidinger, R. A1 - Wollert, Jörg T1 - Simplified rapid-prototyping with automation technology T2 - Automobiles and sustainable mobility : FISITA 2010 World Automotive Congress, 30 May - 4 June, Budapest, Hungary ; proceedings Y1 - 2010 SN - 978-963-9058-29-3 SP - F2010C093 ER - TY - CHAP A1 - Schürmann, Volker A1 - Buda, Aurel A1 - Jonker, Stefan A1 - Palmhof, Norman A1 - Wollert, Jörg T1 - Wireless in future automotive applications T2 - Mobile and wireless communications network layer and circuit level design / ed. by Salma Ait Fares ... Y1 - 2010 SN - 978-953-307-042-1 SP - 71 EP - 92 PB - Intech CY - London ER - TY - CHAP A1 - Buda, Aurel A1 - Schürmann, Volker A1 - Wollert, Jörg T1 - Wireless technologies in factory automation T2 - Factory automation / ed. by Javier Silvestre-Blanes Y1 - 2010 SN - 978-953-7619-42-8 SP - 29 EP - 50 PB - Intech CY - London ER - TY - CHAP A1 - Seibler, Jost A1 - Schwenk, Frieder T1 - Transgenic RNAi Applications in the Mouse T2 - Methods in Enzymology : Guide to Techniques in Mouse Development, Part B: Mouse Molecular Genetics. 2nd Edition Y1 - 2010 SN - 978-0-12-384880-2 N1 - Methods in Enzymology : Vol. 477 SP - 367 EP - 386 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Kirsch, Ansgar T1 - Numerical investigation of the face stability of shallow tunnels in sand T2 - Numerical methods in geotechnical engineering : (NUMGE 2010) : proceedings of the seventh European Conference on Numerical Methods in Geotechnical Engineering, Trondheim, Norway, 2 - 4 June 2010 / ed. by Thomas Benz ... Y1 - 2010 SN - 978-0-415-59239-0 SP - 779 EP - 784 PB - Taylor and Francis CY - London ER - TY - CHAP A1 - Kirsch, Ansgar A1 - Marcher, Thomas T1 - Numerical prediction of time-dependent rock swelling based on an example of a major tunnel project in Ontario/Canada T2 - Numerical methods in geotechnical engineering : (NUMGE 2010) : proceedings of the seventh European Conference on Numerical Methods in Geotechnical Engineering, Trondheim, Norway, 2 - 4 June 2010 / ed. by Thomas Benz ... Y1 - 2010 SN - 978-0-415-59239-0 SP - 297 EP - 302 PB - Taylor and Francis CY - London ER - TY - PAT A1 - O'Connell, Timothy A1 - Siegert, Petra A1 - Maurer, Karl-Heinz A1 - Schiedel, Marc-Steffen A1 - Vockenroth, Inga Kerstin T1 - Method for improving the cleaning action of a detergent or cleaning agent [Internationale Patentanmeldung] T1 - Verfahren zur Verbesserung der Reinigungsleistung eines Wasch- oder Reinigungsmittels Y1 - 2010 SP - 1 EP - 15 PB - WIPO CY - Genf ER - TY - CHAP A1 - Gömmel, Andreas A1 - Niendorf, Thoralf A1 - Frauenrath, Tobias A1 - Otten, Mario A1 - Butenweg, Christoph A1 - Kob, Malte T1 - 3D vocal fold geometry mapping using Magnetic Resonance Imaging T2 - Fortschritte der Akustik : 36. Deutsche Jahrestagung für Akustik ; 15.-18. März 2010, [Berlin ; DAGA 2010] / DEGA ... Wiss. Ed. Michael Möser ... Band 1 Y1 - 2010 SN - 978-3-9808659-8-2 SP - 271 EP - 272 PB - Deutsche Gesellschaft für Akustik CY - Berlin ER - TY - CHAP A1 - Frauenrath, Tobias A1 - Gömmel, Andreas A1 - Butenweg, Christoph A1 - Otten, Mario A1 - Niendorf, Thoralf T1 - 3D mapping of vocal fold geometry during articulatory maneuvers using ultrashort echo time imaging at 3.0 T T2 - ISMRM-ESMRMB joint annual meeting 2010 : Stockholm, Sweden, 1 - 7 May 2010. Band 4 Y1 - 2010 SN - 978-1-617-82008-3 SP - 3087 PB - Curran CY - Red Hook, NY ER - TY - CHAP A1 - Gellert, Christoph A1 - Park, Jin A1 - Butenweg, Christoph T1 - Seismic safety verification of masonry structures T2 - Proceedings of the Eight International Masonry Conference : held in Dresden from 4th to 7th of July 2010 / [International Masonry Society ; Technische Universität Dresden]. Ed. by: Wolfram Jäger ... Volume 1. (Masonry / International Masonry Society Special Publication ; 11) Y1 - 2010 SN - 978-3-00-031381-3 SP - 813 EP - 822 PB - ARGE 8IMC Dresden CY - Radebeul ER - TY - CHAP A1 - Reindl, Lukas A1 - Park, Jin A1 - Norda, Hannah A1 - Butenweg, Christoph T1 - Seismic design of masonry walls subject to out-of-plane bending T2 - Proceedings of the Tenth International Conference on Computational Structures Technology : Valencia, Spain, 14 - 17 September 2010 / organised in association with: Universidad Politecnica de Valencia ... Ed. by B. H. V. Topping ... Y1 - 2010 SN - 978-1-905088-36-2 U6 - http://dx.doi.org/10.4203/ccp.93.348 SP - Paper 348 PB - Civil-Comp Press CY - Kippen ER - TY - CHAP A1 - Evers, Jörg A1 - Fleischhaker, Robert A1 - Pálffy, A. A1 - Keitel, C. T1 - Light propagation : From atomic to nuclear quantum optics T2 - Modern optics and photonics: atoms and structured media Y1 - 2010 SN - 978-981431327-8 U6 - http://dx.doi.org/10.1142/9789814313278_0001 SP - 3 EP - 15 PB - World Scientific Publishing Co. ER - TY - CHAP A1 - Abel, Thomas A1 - Bonin, Dominik A1 - Albracht, Kirsten A1 - Zeller, Sebastian A1 - Brüggemann, Gert-Peter A1 - Burkett, Brendan A1 - Strüder, Heiko K. T1 - Kinematic profile of the elite handcyclist T2 - 28th International Conference on Biomechanics in Sports, Marquette, Michigan, USA, July 19 – 23, 2010 Y1 - 2017 SN - 1999-4168 SP - 140 EP - 141 ER - TY - THES A1 - Albracht, Kirsten T1 - Influence of mechanical properties of the leg extensor muscletendon units on running economy Y1 - 2010 N1 - Cologne, German Sport Univ., Diss., 2010 PB - Deutsche Sporthochschule Köln CY - Köln ER - TY - CHAP A1 - Bitz, Andreas A1 - Kraff, O. A1 - Orzada, S. A1 - Maderwald, S. A1 - Brote, I. A1 - Ladd, M. T1 - Experimental and Numerical Assessment of RF Safety of Transmit Coils at 7 Tesla T2 - ISMRM workshop on MR safety 2010 : RF heating of the human in MRI : workshop series. The Washington County Historic Courthouse, Stillwater, Minnesota, USA, 15 - 17 October 2010 Y1 - 2010 SN - 978-1-62276-088-6 SP - 195 ER - TY - CHAP A1 - Muffler, Kai A1 - Tippkötter, Nils A1 - Ulber, Roland ED - Timmis, Kenneth N. T1 - Chemical feedstocks and fine chemicals from other substrates T2 - Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference) Y1 - 2010 SN - 978-3-540-77588-1 U6 - http://dx.doi.org/10.1007%2F978-3-540-77587-4_214 SP - 2891 EP - 2902 PB - Springer CY - Berlin [u.a.] ER - TY - CHAP A1 - Poth, Sebastian A1 - Monzon, Magaly A1 - Tippkötter, Nils A1 - Ulber, Roland T1 - Lignocellulosic biorefinery : process integration of hydrolysis and fermentation T2 - Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany Y1 - 2010 SP - 65 EP - 68 PB - vTi CY - Hamburg ER - TY - CHAP A1 - Lehnertz, Klaus A1 - Bialonski, Stephan A1 - Horstmann, Marie-Therese A1 - Krug, Dieter A1 - Rothkegel, Alexander A1 - Staniek, Matthäus A1 - Wagner, Tobias T1 - Epilepsy T2 - Reviews of Nonlinear Dynamics and Complexity, Volume 2 Y1 - 2010 SN - 9783527628001 U6 - http://dx.doi.org/10.1002/9783527628001.ch5 SP - 159 EP - 200 PB - Wiley-VCH ER - TY - CHAP A1 - Matcha, Heike A1 - Ljubas, Ante T1 - Parametric Origami: Adaptable temporary buildings T2 - Future cities: 28th eCAADe Conference Proceedings. eCAADe: Conferences. Zurich, Switzerland Y1 - 2010 SN - 978-0-9541183-7-2 SP - 243 EP - 251 ER - TY - JOUR A1 - Becker, Meike A1 - Frauenrath, Tobias A1 - Hezel, Fabian A1 - Krombach, Gabriele A. A1 - Kremer, Ute A1 - Koppers, Benedikt A1 - Butenweg, Christoph A1 - Goemmel, Andreas A1 - Utting, Jane F. A1 - Schulz-Menger, Jeanette A1 - Niendorf, Thoralf T1 - Comparison of left ventricular function assessment using phonocardiogram- and electrocardiogram-triggered 2D SSFP CINE MR imaging at 1.5 T and 3.0 T JF - European Radiology N2 - Objective: As high-field cardiac MRI (CMR) becomes more widespread the propensity of ECG to interference from electromagnetic fields (EMF) and to magneto-hydrodynamic (MHD) effects increases and with it the motivation for a CMR triggering alternative. This study explores the suitability of acoustic cardiac triggering (ACT) for left ventricular (LV) function assessment in healthy subjects (n=14). Methods: Quantitative analysis of 2D CINE steady-state free precession (SSFP) images was conducted to compare ACT’s performance with vector ECG (VCG). Endocardial border sharpness (EBS) was examined paralleled by quantitative LV function assessment. Results: Unlike VCG, ACT provided signal traces free of interference from EMF or MHD effects. In the case of correct Rwave recognition, VCG-triggered 2D CINE SSFP was immune to cardiac motion effects—even at 3.0 T. However, VCG-triggered 2D SSFP CINE imaging was prone to cardiac motion and EBS degradation if R-wave misregistration occurred. ACT-triggered acquisitions yielded LV parameters (end-diastolic volume (EDV), endsystolic volume (ESV), stroke volume (SV), ejection fraction (EF) and left ventricular mass (LVM)) comparable with those derived fromVCG-triggered acquisitions (1.5 T: ESVVCG=(56± 17) ml, EDVVCG=(151±32)ml, LVMVCG=(97±27) g, SVVCG=(94± 19)ml, EFVCG=(63±5)% cf. ESVACT= (56±18) ml, EDVACT=(147±36) ml, LVMACT=(102±29) g, SVACT=(91± 22) ml, EFACT=(62±6)%; 3.0 T: ESVVCG=(55±21) ml, EDVVCG=(151±32) ml, LVMVCG=(101±27) g, SVVCG=(96±15) ml, EFVCG=(65±7)% cf. ESVACT=(54±20) ml, EDVACT=(146±35) ml, LVMACT= (101±30) g, SVACT=(92±17) ml, EFACT=(64±6)%). Conclusions: ACT’s intrinsic insensitivity to interference from electromagnetic fields renders KW - Magnetic resonance imaging (MRI) KW - MR-stethoscope KW - Magnetic field strength KW - Left ventriular function KW - Cardiovascular MRI Y1 - 2010 U6 - http://dx.doi.org/10.1007/s00330-009-1676-z SN - 1432-1084 (Onlineausgabe) SN - 0938-7994 (Druckausgabe) VL - 20 SP - 1344 EP - 1355 PB - Springer CY - Berlin ER - TY - JOUR A1 - Ross, Jillian A1 - Plummer, Simon M. A1 - Rode, Anja A1 - Scheer, Nico A1 - Bower, Conrad C. A1 - Vogel, Ortwin A1 - Henderson, Colin J. A1 - Wolf, C. Roland A1 - Elcombe, Clifford R. T1 - Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo JF - Toxicological Sciences N2 - Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel “humanized” and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained. Y1 - 2010 U6 - http://dx.doi.org/10.1093/toxsci/kfq118 SN - 1096-0929 VL - 116 IS - 2 SP - 452 EP - 466 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Scheer, Nico A1 - Ross, Jillian A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Wolf, C. Roland T1 - In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice JF - Drug Metabolism and Disposition N2 - Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound. Y1 - 2010 U6 - http://dx.doi.org/10.1124/dmd.109.031872 SN - 1521-009X VL - 38 IS - 7 SP - 1046 EP - 1053 PB - ASPET CY - Bethesda ER - TY - JOUR A1 - Czarnecki, Christian A1 - Winkelmann, Axel A1 - Spiliopoulou, Myra T1 - Services in electronic telecommunication markets: a framework for planning the virtualization of processes JF - Electronic Markets N2 - The potential of electronic markets in enabling innovative product bundles through flexible and sustainable partnerships is not yet fully exploited in the telecommunication industry. One reason is that bundling requires seamless de-assembling and re-assembling of business processes, whilst processes in telecommunication companies are often product-dependent and hard to virtualize. We propose a framework for the planning of the virtualization of processes, intended to assist the decision maker in prioritizing the processes to be virtualized: (a) we transfer the virtualization pre-requisites stated by the Process Virtualization Theory in the context of customer-oriented processes in the telecommunication industry and assess their importance in this context, (b) we derive IT-oriented requirements for the removal of virtualization barriers and highlight their demand on changes at different levels of the organization. We present a first evaluation of our approach in a case study and report on lessons learned and further steps to be performed. KW - Telecommunication KW - Services KW - Process virtualization KW - Product bundling KW - Transformation Y1 - 2010 U6 - http://dx.doi.org/10.1007/s12525-010-0045-8 SN - 1422-8890 VL - 20 IS - 3-4 SP - 197 EP - 207 PB - Springer CY - Berlin ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefam T1 - Numerical analysis and implementational aspects of a new multilevel grid deformation method JF - Applied Numerical Mathematics N2 - Recently, we introduced and mathematically analysed a new method for grid deformation (Grajewski et al., 2009) [15] we call basic deformation method (BDM) here. It generalises the method proposed by Liao et al. (Bochev et al., 1996; Cai et al., 2004; Liao and Anderson, 1992) [4], [6], [20]. In this article, we employ the BDM as core of a new multilevel deformation method (MDM) which leads to vast improvements regarding robustness, accuracy and speed. We achieve this by splitting up the deformation process in a sequence of easier subproblems and by exploiting grid hierarchy. Being of optimal asymptotic complexity, we experience speed-ups up to a factor of 15 in our test cases compared to the BDM. This gives our MDM the potential for tackling large grids and time-dependent problems, where possibly the grid must be dynamically deformed once per time step according to the user's needs. Moreover, we elaborate on implementational aspects, in particular efficient grid searching, which is a key ingredient of the BDM. Y1 - 2010 U6 - http://dx.doi.org/10.1016/j.apnum.2010.03.017 SN - 0168-9274 VL - 60 IS - 8 SP - 767 EP - 781 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Borggräfe, Andreas A1 - Dachwald, Bernd T1 - Mission performance evaluation for solar sails using a refined SRP force model with variable optical coefficients T2 - 2nd International Symposium on Solar Sailing N2 - Solar sails provide ignificant advantages over other low-thrust propulsion systems because they produce thrust by the momentum exchange from solar radiation pressure (SRP) and thus do not consume any propellant.The force exerted on a very thin sail foil basically depends on the light incidence angle. Several analytical SRP force models that describe the SRP force acting on the sail have been established since the 1970s. All the widely used models use constant optical force coefficients of the reflecting sail material. In 2006,MENGALI et al. proposed a refined SRP force model that takes into account the dependancy of the force coefficients on the light incident angle,the sail’s distance from the sun (and thus the sail emperature) and the surface roughness of the sail material [1]. In this paper, the refined SRP force model is compared to the previous ones in order to identify the potential impact of the new model on the predicted capabilities of solar sails in performing low-cost interplanetary space missions. All force models have been implemented within InTrance, a global low-thrust trajectory optimization software utilizing evolutionary neurocontrol [2]. Two interplanetary rendezvous missions, to Mercury and the near-Earth asteroid 1996FG3, are investigated. Two solar sail performances in terms of characteristic acceleration are examined for both scenarios, 0.2 mm/s2 and 0.5 mm/s2, termed “low” and “medium” sail performance. In case of the refined SRP model, three different values of surface roughness are chosen, h = 0 nm, 10 nm and 25 nm. The results show that the refined SRP force model yields shorter transfer times than the standard model. Y1 - 2010 N1 - 2nd International Symposium on Solar Sailing, ISSS 2010, 2010-07-20 - 2010-07-22. New York City College of Technology of the City University of New York, USA SP - 1 EP - 6 ER - TY - CHAP A1 - Dachwald, Bernd T1 - Solar sail dynamics and control T2 - Encyclopedia of Aerospace Engineering N2 - Solar sails are large and lightweight reflective structures that are propelled by solar radiation pressure. This chapter covers their orbital and attitude dynamics and control. First, the advantages and limitations of solar sails are discussed and their history and development status is outlined. Because the dynamics of solar sails is governed by the (thermo-)optical properties of the sail film, the basic solar radiation pressure force models have to be described and compared before parameters to measure solar sail performance can be defined. The next part covers the orbital dynamics of solar sails for heliocentric motion, planetocentric motion, and motion at Lagrangian equilibrium points. Afterwards, some advanced solar radiation pressure force models are described, which allow to quantify the thrust force on solar sails of arbitrary shape, the effects of temperature, of light incidence angle, of surface roughness, and the effects of optical degradation of the sail film in the space environment. The orbital motion of a solar sail is strongly coupled to its rotational motion, so that the attitude control of these soft and flexible structures is very challenging, especially for planetocentric orbits that require fast attitude maneuvers. Finally, some potential attitude control methods are sketched and selection criteria are given. KW - solar sail KW - sailcraft KW - orbital dynamics KW - orbit control KW - attitude dynamics Y1 - 2010 U6 - http://dx.doi.org/10.1002/9780470686652.eae292 PB - Wiley CY - Hoboken ER - TY - RPRT A1 - Esch, Thomas A1 - Funke, Harald A1 - Roosen, Petra T1 - SIoBiA – Safety Implications of Biofuels in Aviation N2 - Biofuels potentially interesting also for aviation purposes are predominantly liquid fuels produced from biomass. The most common biofuels today are biodiesel and bioethanol. Since diesel engines are rather rare in aviation this survey is focusing on ethanol admixed to gasoline products. The Directive 2003/30/EC of the European Parliament and the Council of May 8th 2003 on the promotion of the use of biofuels or other renewable fuels for transport encourage a growing admixture of biogenic fuel components to fossil automotive gasoline. Some aircraft models equipped with spark ignited piston engines are approved for operation with automotive gasoline, frequently called “MOGAS” (motor gasoline). The majority of those approvals is limited to MOGAS compositions that do not contain methanol or ethanol beyond negligible amounts. In the past years (bio-)MTBE or (bio-)ETBE have been widely used as blending component of automotive gasoline whilst the usage of low-molecular alcohols like methanol or ethanol has been avoided due to the handling problems especially with regard to the strong affinity for water. With rising mandatory bio-admixtures the conversion of the basic biogenic ethanol to ETBE, causing a reduction of energetic payoff, becomes more and more unattractive. Therefore the direct ethanol admixture is accordingly favoured. Due to the national enforcements of the directive 2003/30/EC more oxygenates produced from organic materials like bioethanol have started to appear in automotive gasolines already. The current fuel specification EN 228 already allows up to 3 % volume per volume (v/v) (bio-)methanol or up to 5 % v/v (bio-)ethanol as fuel components. This is also roughly the amount of biogenic components to comply with the legal requirements to avoid monetary penalties for producers and distributors of fuels. Since automotive fuel is cheaper than the common aviation gasoline (AVGAS), creates less problems with lead deposits in the engine, and in general produces less pollutants it is strongly favoured by pilots. But being designed for a different set of usage scenarios the use of automotive fuel with low molecular alcohols for aircraft operation may have adverse effects in aviation operation. Increasing amounts of ethanol admixtures impose various changes in the gasoline’s chemical and physical properties, some of them rather unexpected and not within the range of flight experiences even of long-term pilots. Y1 - 2010 N1 - Analysis of the safety implications of the use of biofuels (ethanol admixture) for piston engines and general aviation aircraft and assessment of potential environmental benefits. PB - EASA CY - Köln ER - TY - JOUR A1 - Esch, Thomas T1 - Trends in commercial vehicle powertrains JF - ATZautotechnology N2 - Low emission zones and truck bans, the rising price of diesel and increases in road tolls: all of these factors are putting serious pressure on the transport industry. Commercial vehicle manufacturers and their suppliers are in the process of identifying new solutions to these challenges as part of their efforts to meet the EEV (enhanced environmentally friendly vehicle) limits, which are currently the most robust European exhaust and emissions standards for trucks and buses. KW - European Transient Cycle KW - Common Rail Injection System KW - Commercial Vehicle KW - Selective Catalytic Reduction KW - Diesel Engine Y1 - 2010 U6 - http://dx.doi.org/10.1007/BF03247185 SN - 2192-886X VL - 2010 IS - 10 SP - 26 EP - 31 PB - Vieweg & Sohn CY - Wiesbaden ER - TY - JOUR A1 - Bernecker, Andreas T1 - A European Private Company: Is Europe’s single legal form for SMEs close to approval? JF - Research Briefing N2 - This Research Briefing, issued in July 2010, concluded that: - Small and medium-sized enterprises (SMEs) in Europe have long called for a matching legal form valid across the EU (similar to that of the European company (SE) for large firms) - The main benefits would be the availability of uniform Europe-wide company structures, significant cost reductions for businesses and further integration of the internal market - Given the differing national views regarding the concrete features of the new legal form there is currently no sign of an agreement being reached at the European level in the short term; however, it is possible that progress will be made in negotiations during the year - The key issues being discussed in depth are company formation, transnationality and employee participation rights in the new European private company (SPE). Y1 - 2010 SN - 2193-5955 PB - Deutsche Bank Research CY - Frankfurt a. M. ER - TY - JOUR A1 - Akimbekov, N. Sh. A1 - Zhubanova, A. A. A1 - Mansurov, Z. A. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Use of Carbonized Rise Shell for the local treatment of wounds JF - Eurasian ChemTech Journal N2 - On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis. Y1 - 2010 U6 - http://dx.doi.org/10.18321/ectj35 SN - 2522-4867 VL - 12 IS - 2 SP - 133 EP - 138 PB - Institute of Combustion Problems CY - Almaty ER - TY - JOUR A1 - Horstmann, Marie-Therese A1 - Bialonski, Stephan A1 - Noenning, Nina A1 - Mai, Heinke A1 - Prusseit, Jens A1 - Wellmer, Jörg A1 - Hinrichs, Hermann A1 - Lehnertz, Klaus T1 - State dependent properties of epileptic brain networks: Comparative graph–theoretical analyses of simultaneously recorded EEG and MEG JF - Clinical Neurophysiology N2 - Objective To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval. Methods We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics. Results Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings. Conclusions Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks. Significance An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks. Y1 - 2010 U6 - http://dx.doi.org/10.1016/j.clinph.2009.10.013 SN - 1388-2457 VL - 121 IS - 2 SP - 172 EP - 185 PB - Elsevier CY - Amsterdam ER -