TY  - PAT
A1  - Ahlborn, Kristina
A1  - Gerlach, Frank
A1  - Iken, Heiko
A1  - Schöning, Michael Josef
A1  - Vonau, Winfried
T1  - Miniaturisierte, potentiometrische Indikatorelektrode und Verfahren zu deren Herstellung : Offenlegungsschrift
Y1  - 2012
ER  - 
TY  - CHAP
A1  - Dachwald, Bernd
A1  - Feldmann, Marco
A1  - Espe, Clemens
A1  - Plescher, Engelbert
A1  - Konstantinidis, K.
A1  - Forstner, R.
T1  - Enceladus explorer - A maneuverable subsurface probe for autonomous navigation through deep ice
T2  - 63rd International Astronautical Congress 2012, IAC 2012; Naples; Italy; 1 October 2012 through 5 October 2012. (Proceedings of the International Astronautical Congress, IAC ; 3)
Y1  - 2012
SN  - 978-1-62276-979-7
SP  - 1756
EP  - 1766
PB  - Curran
CY  - Red Hook, NY
ER  - 
TY  - CHAP
A1  - Kern, Alexander
A1  - Schelthoff, Christof
A1  - Mathieu, Moritz
T1  - Calculation of interception efficiencies for mesh-type air-terminations according to IEC 62305-3 using a dynamic electro-geometrical model
T2  - International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna
Y1  - 2012
SN  - 978-1-4673-1896-9 (E-Book) ; 978-1-4673-1898-3 (Print)
SP  - 1
EP  - 6
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - CHAP
A1  - Lo Piparo, G. B.
A1  - Kern, Alexander
A1  - Mazzetti, C.
T1  - Some masterpoints about risk due to lightning
T2  - International Conference on Lightning Protection (ICLP) : 2 - 7 Sept. 2012, Vienna
Y1  - 2012
SN  - 978-1-4673-1896-9 (E-Book) ; 978-1-4673-1898-3 (Print)
SP  - 1
EP  - 6
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Bragard, Michael
A1  - van Hoek, H.
A1  - De Doncker, R. W.
T1  - A major design step in IETO concept realization that allows overcurrent protection and pushes limits of switching performance
JF  - IEEE transactions on power electronics
N2  - This paper presents the latest prototype of the integrated emitter turn-off thyristor concept, which potentially ranks among thyristor high-power devices like the gate turn-off thyristor and the integrated gate-commutated thyristor (IGCT). Due to modifications of the external driver stage and mechanical press-pack design optimization, this prototype allows for full device characterization. The turn-off capability was increased to 1600 A with an active silicon area of 823mm2 . This leads to a transient peak power of 672.1kW/cm² . Within this paper, measurements and concept assessment are presented and a comparison to state-of-the-art IGCT devices is provided.
Y1  - 2012
U6  - https://doi.org/10.1109/TPEL.2012.2189136
SN  - 0885-8993
VL  - 27
IS  - 9
SP  - 4163
EP  - 4171
PB  - IEEE
CY  - New York
ER  - 
TY  - JOUR
A1  - Bragard, G.
A1  - Bragard, Michael
T1  - Ein kostengünstiges, universelles Modellbauinterface
JF  - Der mathematische und naturwissenschaftliche Unterricht : MNU ; Organ des Deutschen Vereins zur Förderung des Mathematischen und Naturwissenschaftlichen Unterrichts e.V.
N2  - Wir stellen einen USB-Baustein vor, der eine kostengünstige und universelle Möglichkeit schafft , im Unterricht den Themenkreis Messen-Steuern-Regeln zu behandeln. Die Funktionalität orientiert sich am CVK-Interface der Firma Fischertechnik. Im Gegensatz zu kommerziellen Lösungen erlaubt unser Aufbau auch den preiswerten Einsatz in Gruppen- oder Einzelarbeit. Abschließend berichten wir über ein Beispiel aus dem Unterrichtseinsatz.
Y1  - 2012
SN  - 0025-5866
VL  - 65
IS  - 5
SP  - 290
EP  - 293
PB  - Seeberger
CY  - Neuss
ER  - 
TY  - THES
A1  - Bragard, Michael
T1  - The integrated emitter turn-off thyristor : an innovative MOS-gated high-power device. - (Aachener Beiträge des ISEA ; 62)
N2  - This thesis introduces the Integrated Emitter Turn-Off (IETO) Thyristor as a new high-power device. Known state-of-the-art research activities like the Dual GCT, the ETO thyristor and the ICT were presented and critically reviewed. A comparison with commercialized solutions identifies the pros and cons of each type of device family. Based on this analysis, the IETO structure is proposed, covering most benefits of each device class. In particular the combination of a MOS-assisted turn-off with a thyristor-based device allows a voltage-controlled MOS switching and the low on-state voltage of the thyristors. The following synthesis of an IETO device stands on a three-dimensional field of optimization spanned by electric, mechanical and thermal aspects. From an electric point of view, the lowest possible parasitic inductance and resistance within the commutation path are optimization criteria. The mechanical construction has to withstand the required contact pressure of multiple kilo Newtons. Finally, thermal borders limit the maximum average current of the device. FEM simulations covering these three aspects are performed for several design proposals. An IETO prototype is constructed and measurements on various test benches attest thermal, mechanical and electric performance. A local decoupling of the external driver stage and the presspack housing is presented by a cable connection. This separation enables a thermal and mechanical independence, which is advantageous in terms of vibrations and thermal cycles including increased reliability. The electric pulse performance of the prototype device is a factor of 3.1 above today''s solutions. In single-pulse measurements, a current up to 1600 A was successfully turned off at 115°C with an active silicon area of 823 mm². One reason for this increased turn-off capability is the extremely low-inductive construction. Additional functionality of the IETO thyristor like over-current self-protection and defined short-circuit failure state are successfully verified.
Y1  - 2012
SN  - 978-3-8440-1152-4
N1  - Zugl.: Aachen, Techn. Hochsch., Diss., 2012
PB  - Shaker
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Rigling, Andreas
A1  - Elkin, Ché
A1  - Dobbertin, Matthias
A1  - Eilmann, Britta
A1  - Giuggiola, Arnaud
A1  - Wohlgemuth, Thomas
A1  - Bugmann, Harald
T1  - Wald und Klimawandel in der inneralpinen Trockenregion Visp
JF  - Schweizerische Zeitschrift für Forstwesen
N2  - Der Temperaturanstieg der vergangenen Jahrzehnte war in Gebirgsregionen besonders ausgeprägt. Sollte sich dieser Temperaturtrend im 21. Jahrhundert fortsetzen, dann dürf-ten sich auch die Häufigkeit und Intensität von Niederschlä-gen und Trockenperioden verändern, was die Waldwirtschaft vor grosse Herausforderungen stellen wird. Trockenheit ist ein entscheidender Faktor für die Waldökosysteme der inner-alpinen Täler, wo seit Jahren trockenheitsbedingtes Baum-sterben festgestellt wird. Der vorliegende Beitrag hat zum Ziel, die Sensitivität der verschiedenen Waldökosysteme ge-genüber Klimawandel und alternative, teilweise extreme Bewirtschaftungsvarianten in der Region Visp zu testen. Me-thodische Ansätze wie Monitoring, Feldexperimente und dy-namische Modellierung wurden kombiniert, und es wurden verschiedene Ökosystemleistungen berücksichtigt, so Holz-produktion, Schutz vor Naturgefahren, Kohlenstoffspeiche-rung und Aspekte der Biodiversität. Die Resultate deuten da-rauf hin, dass auf den Trockenstandorten der Tieflagen die einheimischen Baumarten an ihre physiologischen Grenzen stossen und längerfristig über alternative Baumarten nach-gedacht werden sollte. In den mittleren Lagen dürften Tro-ckenheit und Schadinsekten wie die Borkenkäfer die zukünf-tige Waldentwicklung steuern. In den Hochlagen hingegen werden sich die Wälder ausdehnen und besser wachsen als heute. Alle untersuchten Ökosystemleistungen werden ge-bietsweise starken Veränderungen unterworfen sein. Die dis-kutierten Bewirtschaftungsvarianten scheinen dazu geeignet, die Wasserverfügbarkeit der Bestände, hauptsächlich in tief-eren Lagen, zu erhöhen und dadurch die Widerstandskraft der Bäume gegenüber Trockenperioden vorübergehend zu stärken. Es ist aber davon ausgehen, dass nur verhältnismäs-sig starke Eingriffe wesentliche Effekte erzielen können. Die Verknüpfung von Umweltmonitoring, Feldexperimenten und Modellierung unter Miteinbezug von Ökosystemleistungen ist vielversprechend, da sie eine differenzierte Abschätzung des zukünftigen Landschaftswandels und seiner Effekte auf die Waldleistungen ermöglicht.
Y1  - 2012
U6  - https://doi.org/10.3188/szf.2012.0481
SN  - 2235-1469 (Online)
SN  - 0036-7818 (Print)
VL  - 163
IS  - 12
SP  - 481
EP  - 492
PB  - Schweizerischer Forstverein
CY  - Zürich
ER  - 
TY  - CHAP
A1  - Nötzold, K.
A1  - Uphues, A.
A1  - Wegener, R.
A1  - Soter, S.
A1  - Fink, K.
A1  - Bragard, Michael
A1  - Griessel, R.
T1  - Inverter based test setup for LVRT verification of a full-scale 2 MW wind power converter
T2  - EPE Joint Wind Energy and T&D Chapters Seminar : 28th and 29th of June 2012, in the Utzon Centre, Aalborg, Denmark ; papers, posters, presentations. - Session 2: Grid connection, compliance
Y1  - 2012
PB  - EPE Association
CY  - Brussels
ER  - 
TY  - CHAP
A1  - Bagayoko, Lamine
A1  - Geissler, Karsten
A1  - Koch, Eckart
T1  - Dynamik bei Eisenbahnbrücken
T2  - Stahlbau-Kalender : [Eurocode-3-Grundnorm; Brücken] ; Jg. 14 /  hrsg. von Ulrike Kuhlmann
Y1  - 2012
SN  - 978-3-433-02988-6
SP  - 575
EP  - 632
PB  - Ernst & Sohn
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Eilmann, Britta
A1  - Rigling, Andreas
ED  - Abrams, Marc
T1  - Tree-growth analyses to estimate tree species' drought tolerance
JF  - Tree Physiology
N2  - Climate change is challenging forestry management and practices. Among other things, tree species with the ability to cope with more extreme climate conditions have to be identified. However, while environmental factors may severely limit tree growth or even cause tree death, assessing a tree species' potential for surviving future aggravated environmental conditions is rather demanding. The aim of this study was to find a tree-ring-based method suitable for identifying very drought-tolerant species, particularly potential substitute species for Scots pine (Pinus sylvestris L.) in Valais. In this inner-Alpine valley, Scots pine used to be the dominating species for dry forests, but today it suffers from high drought-induced mortality. We investigate the growth response of two native tree species, Scots pine and European larch (Larix decidua Mill.), and two non-native species, black pine (Pinus nigra Arnold) and Douglas fir (Pseudotsuga menziesii Mirb. var. menziesii), to drought. This involved analysing how the radial increment of these species responded to increasing water shortage (abandonment of irrigation) and to increasingly frequent drought years. Black pine and Douglas fir are able to cope with drought better than Scots pine and larch, as they show relatively high radial growth even after irrigation has been stopped and a plastic growth response to drought years. European larch does not seem to be able to cope with these dry conditions as it lacks the ability to recover from drought years. The analysis of trees' short-term response to extreme climate events seems to be the most promising and suitable method for detecting how tolerant a tree species is towards drought. However, combining all the methods used in this study provides a complete picture of how water shortage could limit species.
Y1  - 2012
U6  - https://doi.org/10.1093/treephys/tps004
SN  - 0829-318X (Print)
SN  - 1758-4469 (Online)
VL  - 32
IS  - 2
SP  - 178
EP  - 187
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Rigling, Andreas
A1  - Bigler, Christof
A1  - Eilmann, Britta
A1  - Feldmeyer-Christe, Elisabeth
A1  - Gimmi, Urs
A1  - Ginzler, Christian
A1  - Graf, Ulrich
A1  - Mayer, Phillip
A1  - Vacchiano, Giorgio
A1  - Weber, Pascal
A1  - Wohlgemuth, Thomas
A1  - zweifel, Roman
A1  - Dobbertin, Matthias
T1  - Driving factors of a vegetation shift from Scots pine to pubescent oak in dry Alpine forests
JF  - Global Change Biology
N2  - An increasing number of studies have reported on forest declines and vegetation shifts triggered by drought. In the Swiss Rhone valley (Valais), one of the driest inner-Alpine regions, the species composition in low elevation forests is changing: The sub-boreal Scots pine (Pinus sylvestris L.) dominating the dry forests is showing high mortality rates. Concurrently the sub-Mediterranean pubescent oak (Quercus pubescens Willd.) has locally increased in abundance. However, it remains unclear whether this local change in species composition is part of a larger-scale vegetation shift. To study variability in mortality and regeneration in these dry forests we analysed data from the Swiss national forest inventory (NFI) on a regular grid between 1983 and 2003, and combined it with annual mortality data from a monitoring site. Pine mortality was found to be highest at low elevation (below 1000 m a.s.l.). Annual variation in pine mortality was correlated with a drought index computed for the summer months prior to observed tree death. A generalized linear mixed-effects model indicated for the NFI data increased pine mortality on dryer sites with high stand competition, particularly for small-diameter trees. Pine regeneration was low in comparison to its occurrence in the overstorey, whereas oak regeneration was comparably abundant. Although both species regenerated well at dry sites, pine regeneration was favoured at cooler sites at higher altitude and oak regeneration was more frequent at warmer sites, indicating a higher adaptation potential of oaks under future warming. Our results thus suggest that an extended shift in species composition is actually occurring in the pine forests in the Valais. The main driving factors are found to be climatic variability, particularly drought, and variability in stand structure and topography. Thus, pine forests at low elevations are developing into oak forests with unknown consequences for these ecosystems and their goods and services.
Y1  - 2012
U6  - https://doi.org/10.1111/gcb.12038
SN  - 1354-1013 (Print)
SN  - 1365-2486 (Online)
VL  - 19
IS  - 1
SP  - 229
EP  - 240
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Weil, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Cherstvy, A.
T1  - Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - https://doi.org/10.5162/IMCS2012/P2.5.2
SP  - 1575
EP  - 1578
ER  - 
TY  - CHAP
A1  - Bohrn, Ulrich
A1  - Mucha, Andreas
A1  - Werner, Frederik
A1  - Stütz, Evamaria
A1  - Bäcker, Matthias
A1  - Krumbe, Christoph
A1  - Schienle, Meinrad
A1  - Fleischer, Maximilian
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Detection of toxic chromium species in water using cellbased sensor systems
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - https://doi.org/10.5162/IMCS2012/P2.1.14
SP  - 1364
EP  - 1367
ER  - 
TY  - CHAP
A1  - Bohrn, Ulrich
A1  - Stütz, Evamaria
A1  - Fleischer, Maximilian
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
T1  - Living cell-based gas sensor system for the detection of acetone in air
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - https://doi.org/10.5162/IMCS2012/3.2.3
SP  - 269
EP  - 272
ER  - 
TY  - CHAP
A1  - Takenaga, Shoko
A1  - Werner, Frederik
A1  - Sawada, Kazuaki
A1  - Schöning, Michael Josef
T1  - Comparison of label-free ACh image sensors based on CCD and LAPS
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - https://doi.org/10.5162/IMCS2012/4.2.6
SP  - 356
EP  - 359
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Bäcker, Matthias
T1  - Chip-basierte Sensoren für die Biotechnik
Y1  - 2012
SN  - 1611-0854
N1  - 4 Seiten
VL  - 13
IS  - 2
PB  - BIOCOM
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Schubert, Jürgen
A1  - Schöning, Michael Josef
T1  - Dünnschichtsensoren für die Schwermetallanalytik : Mikroelektroden auf Chalkogenidglasbasis
JF  - GIT Labor-Fachzeitschrift
N2  - Die Detektion von Schadstoffen repräsentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte Dünnschichtsensoren bieten eine kostengünstige Möglichkeit, „online“-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuführen. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgläsern zur Detektion von Schwermetallen in wässrigen Medien vorgestellt.
Y1  - 2012
IS  - 4
SP  - 285
EP  - 287
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Ritz, Thomas
A1  - Terhaar, Kristin
A1  - Wallenborn, Ramona
ED  - Reiterer, Harald
T1  - HMI für eCarSharing : ein Baustein für nachhaltige Mobilität
T2  - Mensch & Computer 2012 - Workshopband : 12. Fachübergreifende Konferenz für interaktive und kooperative Medien ; interaktiv informiert - allgegenwärtig und allumfassend!?
Y1  - 2012
SN  - 978-3-486-71990-1 (Print)
SN  - 978-3-486-71991-8 (E-Book)
U6  - https://doi.org/10.1524/9783486719918.341
N1  - Workshop Automotive HMI
SP  - 381
EP  - 388
PB  - Oldenbourg
CY  - München
ER  - 
TY  - CHAP
A1  - Fuchs, Britta
A1  - Ritz, Thomas
A1  - Strauch, Jakob
ED  - Obaidat, Mohammad S.
T1  - Usability of mobile applications : dissemination of usability engineering in small and medium enterprises
T2  - Proceedings of the International Conference on Data Communication Networking, e-Business and Optical Communication Systems : Rome, Italy, 24 - 27 July, 2012 ; [integrated in the ICETE (International Conference on e-Business and Telecommunications)]
Y1  - 2012
SN  - 978-989-8565-23-5
N1  - Nebentitel: DCNET; ICE-B; OPTICS
SP  - 272
EP  - 277
PB  - SciTePress
CY  - [Lissabon]
ER  - 
TY  - CHAP
A1  - Ritz, Thomas
A1  - Strauch, Jakob
ED  - Back, Andrea
T1  - Strukturierte Ermittlung beeinflussender Faktoren für mobile Softwarelösungen
T2  - MMS 2012 : mobile und ubiquitäre Informationssysteme ; 7. Konferenz zur "Mobile und Ubiquitäre Informationssysteme" ; 01 - 02. März 2012 in Braunschweig, Germany. - (GI-Edition lecture notes in informatics ; 202)
Y1  - 2012
SN  - 978-3-88579-296-3 (CD-ROM-Ausg.)
PB  - Ges. für Informatik
CY  - Bonn
ER  - 
TY  - CHAP
A1  - Kötter, Jens
A1  - Decker, Stefan
A1  - Detzler, Raphael
A1  - Schäfer, Jochen
A1  - Schmitz, Mark
A1  - Herrmann, Ulf
T1  - Cost Reduction of Solar Fields with HelioTrough Collector
Y1  - 2012
N1  - Concentration Solar Power and Chemical Energy Systemes : SolarPaces 2012, September 11 14 2002, Marrakesh, Morroco
PB  - FLAGSOL
CY  - Köln
ER  - 
TY  - JOUR
A1  - Fissabre, Anke
A1  - Lohmann, Daniel
T1  - Verlust einer „tragenden Wand“ : Das Haus der Jugend von Rudolf Schwarz in Aachen
JF  - Bauwelt
Y1  - 2012
SN  - 0005-6855
VL  - 103
IS  - 45
SP  - 6
EP  - 7
PB  - Bauverlag BV
CY  - Gütersloh
ER  - 
TY  - CHAP
A1  - Fissabre, Anke
A1  - Wilson, Ariane
T1  - "Lehmbaupropaganda" - Gegensätzliche Ideologien über Nachhaltigkeit in der Literatur über den Lehmbau
T1  - “Lehmbaupropaganda” - Contrasting ideologies of sustainability in earth building literature
T2  - Lehm 2012 : Tagungsbeiträge der 6. Internationalen Fachtagung für Lehmbau = 6th International Conference on Building with Earth
Y1  - 2012
SN  - 9783000396496
SP  - 200
EP  - 213
PB  - Eigenverl. Dachverband Lehm
CY  - Weimar
ER  - 
TY  - CHAP
A1  - Fissabre, Anke
A1  - Schmidt, Klaus
A1  - Sonnleitner, Andrea
T1  - Das Lehnsmühlschloß in Ortrand – ein sächsisches Herrenhaus der Renaissance
T2  - Wandel im Wohnbau zwischen Gotik und Barock : die sächsisch-böhmische Entwicklung im überregionalen Vergleich
Y1  - 2012
SN  - 978-3-89445-390-9
N1  - Jahrbuch für Hausforschung ; 53
SP  - 487
EP  - 501
PB  - Jonas
CY  - Marburg
ER  - 
TY  - CHAP
A1  - Borchert, Jörg
A1  - Lintzel, P.
ED  - Zenke, Ines
T1  - Risiken des Handels
T2  - Energiehandel in Europa
Y1  - 2012
SN  - 978-3-9813142-9-8
SP  - 303
EP  - 312
PB  - Beck
CY  - München
ET  - 3. Aufl.
ER  - 
TY  - CHAP
A1  - Borchert, Jörg
ED  - Zenke, Ines
T1  - Aufbau von Handelseinheiten
T2  - Energiehandel in Europa
Y1  - 2012
SN  - 978-3-406-63237-2
SP  - 467
EP  - 479
PB  - Beck
CY  - München
ET  - 3. Aufl.
ER  - 
TY  - CHAP
A1  - Borchert, Jörg
A1  - Michels, A.
ED  - Zenke, ines
T1  - Beschaffungsstrategien an der Schnittstelle Energiehandel / Vertrieb
T2  - Energiehandel in Europa
Y1  - 2012
SN  - 978-3-406-63237-2
SP  - 508
EP  - 522
PB  - Beck
CY  - München
ET  - 3. Aufl.
ER  - 
TY  - CHAP
A1  - Vismann, Ulrich
T1  - Stahlbetonbau
T2  - Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.
Y1  - 2012
SN  - 978-3-8348-0999-5 ; 978-3-8348-8229-5
U6  - https://doi.org/10.1007/978-3-8348-8229-5_9
SP  - 223
EP  - 262
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Stroetmann, Richard
A1  - Lohse, Wolfram
T1  - Stahlbau
T2  - Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.
Y1  - 2012
SN  - 978-3-8348-0999-5 ; 978-3-8348-8229-5
U6  - https://doi.org/10.1007/978-3-8348-8229-5_10
SP  - 263
EP  - 361
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Feiser, Johannes
T1  - Geotechnik
T2  - Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.
Y1  - 2012
SN  - 978-3-8348-0999-5 ; 978-3-8348-8229-5
U6  - https://doi.org/10.1007/978-3-8348-8229-5_14
SP  - 453
EP  - 495
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Strohmeier, Andreas
T1  - Siedlungswasserwirtschaft
T2  - Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.
Y1  - 2012
SN  - 978-3-8348-0999-5 ; 978-3-8348-8229-5
U6  - https://doi.org/10.1007/978-3-8348-8229-5_16
SP  - 527
EP  - 566
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - CHAP
A1  - Biener, Ernst
T1  - Abfallwirtschaft
T2  - Wendehorst Beispiele aus der Baupraxis. - 4. Aufl.
Y1  - 2012
SN  - 978-3-8348-0999-5 ; 978-3-8348-8229-5
U6  - https://doi.org/10.1007/978-3-8348-8229-5_17
SP  - 567
EP  - 603
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Henken, F. E.
A1  - Oosterhuis, K.
A1  - Öhlschläger, Peter
A1  - Bosch, L.
A1  - Hooijberg, E.
A1  - Haanen, J. B. A. G.
A1  - Steenbergen, R. D. M.
T1  - Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7
JF  - Vaccine
N2  - Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of ‘gene-shuffled’ (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.
Y1  - 2012
U6  - https://doi.org/10.1016/j.vaccine.2012.04.013
SN  - 0264-410X
VL  - 30
IS  - 28
SP  - 4259
EP  - 4266
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Immel, Timo
A1  - Grützke, Martin
A1  - Späte, Anne-Katrin
A1  - Groth, Ulrich
A1  - Öhlschläger, Peter
A1  - Huhn, Thomas
T1  - Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy
JF  - Chemical Communications
N2  - Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
Y1  - 2012
U6  - https://doi.org/10.1039/C2CC31624B
SN  - 1364-548X
VL  - 48
IS  - 46
SP  - 5790
EP  - 5792
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - BOOK
A1  - Vismann, Ulrich
T1  - Wendehorst Beispiele aus der Baupraxis / Ulrich Vismann (Hrsg.). - 4., durchges. und aktualis. Aufl.
Y1  - 2012
SN  - 978-3-8348-0999-5 ; 978-3-8348-8229-5
U6  - https://doi.org/10.1007/978-3-8348-8229-5
PB  - Springer Vieweg
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Holtschoppen, Britta
T1  - Neuer VCI-Leitfaden für die erdbebensichere Auslegung von Industrieanlagen
JF  - Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik
Y1  - 2012
SN  - 1436-4867 (E-Journal); 0005-6650 (Print)
VL  - Band 87
SP  - S18
PB  - VDI Fachmedien
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Fehling, Ekkehard
T1  - Hintergrund für die vereinfachten Regeln bei Mauerwerksgebäuden im Erdbebenfall
JF  - Mauerwerk : European journal of masonry
N2  - Bei der Ausarbeitung des nationalen Anwendungsdokumentes zur DIN EN 1998-1 waren die in der ENV-Fassung enthaltenen vereinfachten Regeln im Lichte aktueller Forschungsergebnisse zu überprüfen und zu überarbeiten. Die gleiche Aufgabe stellte sich auch für die Neufassung der DIN 4149. In beiden Fällen sind neben konstruktiven Regeln für die Art und Anordnung der zur Gebäudeaussteifung heranzuziehenden Wände im Grundriss Tabellen enthalten, die unter bestimmten Bedingungen den Entfall eines rechnerischen Nachweises der Tragwände im Erdbebenfall ermöglichen. Dies ist für Schwachbebengebiete, wie sie in Deutschland und anderen Ländern Mitteleuropas anzutreffen sind, sinnvoll, um unnötigen Rechenaufwand sowie Probleme mit der Führbarkeit von Nachweisen so weit wie möglich auszuschalten. Im vorliegenden Beitrag werden die Hintergründe der vereinfachten Regeln diskutiert und die Ergebnisse der Anwendung mit verschiedenen Rechenverfahren verglichen und bewertet.
Y1  - 2012
U6  - https://doi.org/10.1002/dama.201200537
SN  - 1437-1022 (E-Journal); 1432-3427 (Print)
VL  - Volume 16
IS  - Issue 3
SP  - 127
EP  - 137
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Gellert, Christoph
T1  - Integrale Gebäudeplanung am Beispiel eines Geschossbaus in Ziegelmauerwerk
JF  - Mauerwerk : European journal of masonry
N2  - Moderne Mauerwerksbauten müssen nach heutigen Anforderungen architektonisch, statisch, energetisch sowie schall- und brandschutztechnisch optimal ausgelegt sein. Aufgrund der Komplexität und engen Verzahnung der einzelnen Anforderungen ist eine integrale Gebäudeplanung zur Erzielung einer qualitativ hochwertigen Bauwerkslösung unbedingt notwendig. Diese erfordert von den Fachplanern vertieftes Spezialwissen in den verschiedenen Bereichen, um insbesondere die Schnittstellen und Bauwerksdetails korrekt zu planen und auszuführen. Der Beitrag stellt die integrale Gebäudeplanung am Beispiel eines Geschossbaus in Ziegelbauweise mit Lösungen für wesentliche Detailpunkte vor
Y1  - 2012
U6  - https://doi.org/10.1002/dama.201200550
SN  - 1437-1022 (E-Journal); 1432-3427 (Print)
VL  - Volume 16
IS  - 5
SP  - 247
EP  - 254
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - PAT
A1  - Bagheri, Mohsen
A1  - Dahmann, Peter
T1  - Kletterroboter mit Gurtantrieb international [Offenlegungsschrift]
T1  - Climbing robot for masts [Europäische Patentanmeldung / Internationale Patentanmeldung / US Patentanmeldung]
Y1  - 2012
SP  - 1
EP  - 20
PB  - Deutsches Patentamt / Europäisches Patentamt / WIPO / USPTO
CY  - München / Den Hague / Genf / Alexandria, Virginia
ER  - 
TY  - JOUR
A1  - Staat, Manfred
T1  - Limit and shakedown analysis under uncertainty
JF  - Tap chi Khoa hoc & ung dung - Dai hoc Ton Duc Thang
Y1  - 2012
N1  - = Journal of Applied Sciences - Ton Duc Thang University
VL  - 19
SP  - 45
EP  - 47
ER  - 
TY  - JOUR
A1  - Wilke, Thomas
T1  - Architekturzeichnung als Instrument der Theoriebildung. Lineamenta vs. Portraicture – Architekturdarstellung zwischen Wissenschaft und Öffentlichkeit. Tagung des DFG-Netzwerks-Schnittstelle Bild in Zusammenarbeit mit dem Lehrstuhl für Kunstgeschichte der Universität Regensburg, 28.4.2012.
JF  - Kunstchronik
Y1  - 2012
SN  - 0023-5474
VL  - 65
IS  - 9/10
SP  - 494
EP  - 499
PB  - Fachverlag Hans Carl
CY  - Nürnberg
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Balimane, Praveen
A1  - Hayward, Michael D.
A1  - Buechel, Sandra
A1  - Kauselmann, Gunther
A1  - Wolf, C. Roland
T1  - Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
JF  - Drug Metabolism and Disposition
N2  - The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(−/−)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(−/−) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.
Y1  - 2012
U6  - https://doi.org/10.1124/dmd.112.047605
SN  - 1521-0111
VL  - 40
IS  - 11
SP  - 2212
EP  - 2218
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - Rode, Anja
A1  - Buechel, Sandra
A1  - Wolf, C. Roland
T1  - Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines
JF  - Molecular Pharmacology
N2  - Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.112.080036
SN  - 1521-0111
VL  - 82
IS  - 6
SP  - 1022
EP  - 1029
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Lempiäinen, Harri
A1  - Couttet, Philippe
A1  - Bolognani, Federico
A1  - Müller, Arne
A1  - Dubost, Valérie
A1  - Luisier, Raphaëlle
A1  - Rio-Espinola, Alberto del
A1  - Vitry, Veronique
A1  - Unterberger, Elif B.
A1  - Thomson, John P.
A1  - Treindl, Fridolin
A1  - Metzger, Ute
A1  - Wrzodek, Clemens
A1  - Hahne, Florian
A1  - Zollinger, Tulipan
A1  - Brasa, Sarah
A1  - Kalteis, Magdalena
A1  - Marcellin, Magali
A1  - Giudicelli, Fanny
A1  - Braeuning, Albert
A1  - Morawiec, Laurent
A1  - Zamurovic, Natasa
A1  - Längle, Ulrich
A1  - Scheer, Nico
A1  - Schübeler, Dirk
A1  - Goodman, Jay
A1  - Chibout, Salah-Dine
A1  - Marlowe, Jennifer
A1  - Theil, Dietlinde
A1  - Heard, David J.
A1  - Grenet, Olivier
A1  - Zell, Andreas
A1  - Templin, Markus F.
A1  - Meehan, Richard R.
A1  - Wolf, Roland C.
A1  - Elcombe, Clifford R.
A1  - Schwarz, Michael
A1  - Moulin, Pierre
A1  - Terranova, Rémi
A1  - Moggs, Jonathan G.
T1  - Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion
JF  - Toxicological Sciences
N2  - The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.
Y1  - 2012
U6  - https://doi.org/10.1093/toxsci/kfs303
SN  - 1094-2025
VL  - 131
IS  - 2
SP  - 375
EP  - 386
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Mansurov, Z.
A1  - Digel, Ilya
A1  - Biisenbaev, M.
A1  - Savistkaya, I.
A1  - Kistaubaeva, A.
A1  - Akimbekov, Nuraly S.
A1  - Zhubanova, A.
T1  - Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications
JF  - Eurasian Chemico-Technological Journal
Y1  - 2012
U6  - https://doi.org/10.18321/ectj105
SN  - 2522-4867
VL  - 14
IS  - 2
SP  - 115
EP  - 131
PB  - Institute of Combustion Problems
CY  - Almaty
ER  - 
TY  - CHAP
A1  - Bitz, Andreas
A1  - Kraff, O.
A1  - Orzada, S.
A1  - Maderwald, S.
A1  - Brote, I.
A1  - Johst, S.
A1  - Ladd, E.
T1  - Assessment of RF Safety of Transmit Coils at 7 Tesla by Experimental and Numerical Procedures (490.)
T2  - 19th annual ISMRM scientific meeting and exhibition 2011 : Montreal, Quebec, Canada, 7 - 13 May 2011
Y1  - 2012
SN  - 978-1-61839-284-8
IS  - Volume 1
SP  - 475
PB  - Curran
CY  - Red Hook, NY
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Kong, Shushu
A1  - Arciszewski, Pawel
A1  - Wielbalck, Swantje
A1  - Abram, Ulrich
T1  - Aryl and NHC Compounds of Technetium and Rhenium
JF  - Journal of the American Chemical Society
N2  - Air- and water-stable phenyl complexes with nitridotechnetium(V) cores can be prepared by straightforward procedures. [TcNPh2(PPh3)2] is formed by the reaction of [TcNCl2(PPh3)2] with PhLi. The analogous N-heterocyclic carbene (NHC) compound [TcNPh2(HLPh)2], where HLPh is 1,3,4-triphenyl-1,2,4-triazol-5-ylidene, is available from (NBu4)[TcNCl4] and HLPh or its methoxo-protected form. The latter compound allows the comparison of different Tc–C bonds within one compound. Surprisingly, the Tc chemistry with such NHCs does not resemble that of corresponding Re complexes, where CH activation and orthometalation dominate.
Y1  - 2012
U6  - https://doi.org/10.1021/ja3033718
SN  - 1520-5126
VL  - 134
IS  - 22
SP  - 9118
EP  - 9121
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Paulßen, Elisabeth
A1  - Ngyugen, Hung Huy
A1  - Kahlcke, Nils
A1  - Deflon, Victor M.
A1  - Abram, Ulrich
T1  - Tricarbonyltechnetium(I) and -rhenium(I) complexes with N′-thiocarbamoylpicolylbenzamidines
JF  - Polyhedron
N2  - N,N-Dialkylamino(thiocarbonyl)-N′-picolylbenzamidines react with (NEt4)2[M(CO)3X3] (M = Re, X = Br; M = Tc, X = Cl) under formation of neutral [M(CO)3L] complexes in high yields. The monoanionic NNS ligands bind in a facial coordination mode and can readily be modified at the (CS)NR1R2 moiety. The complexes [99Tc(CO)3(LPyMor)] and [Re(CO)3(L)] (L = LPyMor, LPyEt) were characterized by X-ray diffraction. Reactions of [99mTc(CO)3(H2O)3]+ with the N′-thiocarbamoylpicolylbenzamidines give the corresponding 99mTc complexes. The ester group in HLPyCOOEt allows linkage between biomolecules and the metal core.
Y1  - 2012
U6  - https://doi.org/10.1016/j.poly.2012.04.008
SN  - 0277-5387
VL  - 40
IS  - 1
SP  - 153
EP  - 158
PB  - Elsevier
CY  - Amsterdam
ER  -