TY - JOUR A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Savitkaya, I.S. A1 - Zhubanova, A.A. A1 - Tastambek, K.T. T1 - Investigations of LPS endotoxin elimination in the flowing column conditions with the sorbent on the basis of carbonized rice husk JF - KazNU Bulletin. Biology series Y1 - 2013 SN - 1563-0218 N1 - Original in russischer Sprache VL - 57 IS - 1 SP - 124 EP - 127 ER - TY - JOUR A1 - Laack, Walter van A1 - Refisch, A. T1 - Die neuralgische Amyotrophie des Lumbalbereiches / Refisch, A. ; Laack, W. van JF - Orthopädische Praxis. 7 (1989) Y1 - 1989 SN - 0030-588x SP - 437 ER - TY - JOUR A1 - Fabo, Sabine T1 - Joseph Beuys und das Kapital : zur Erweiterung eines Begriffs JF - Diagonal : Zeitschrift der Universität Siegen Y1 - 1991 SN - 0938-7161 VL - 2 (1991) IS - Heft "Geld" SP - 145 EP - 152 ER - TY - JOUR A1 - Gerigk, M. A1 - Bujnicki, R. A1 - Ganpo-Nkwenkwa, E. A1 - Bongaerts, Johannes A1 - Sprenger, G. A1 - Takors, Ralf T1 - Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains JF - Biotechnology and bioengineering Y1 - 2002 SN - 1097-0290 (E-Journal); 0006-3592 (Print) VL - Vol. 80 IS - Iss. 7 SP - 746 EP - 754 ER - TY - JOUR A1 - Ferrein, Alexander A1 - Jacobs, Stefan A1 - Lakemeyer, Gerhard T1 - Unreal Golog Bots / Jacobs, Stefan ; Ferrein, Alexander ; Lakemeyer, Gerhard JF - IJCAI-05 Workshop on Reasoning, Representation, and Learning in Computer Games Y1 - 2005 SP - 31 EP - 36 ER - TY - JOUR A1 - Laack, Walter van A1 - Ohnsorge, J. T1 - Technik und Ergebnisse der arthroskopischen Fixation von Dissekaten an der medialen Femurrolle mit resorbierbaren EthipinR-Stiften JF - Abstracts : SICOT 87, XVII. world congress, Munich, 16 - 21 August 1987 / [ed.: H. Wagner] Y1 - 1987 SN - 3-921512-85-9 N1 - International Society of Orthopaedic Surgery and Traumatology / Société Internationale de Chirurgie Orthopédique et de Traumatologie SP - 277 PB - Demeter CY - Gräfelfing ER - TY - JOUR A1 - Fabo, Sabine T1 - Entgrenzung und Vereinnahmung : zum Verhältnis von Kunst und Kunstbetrieb in den 80er Jahren JF - Aufbruch in die Neunziger : Ideen, Entwicklungen, Perspektiven der achtziger Jahre / Christian W. Thomsen (Hrsg.) Y1 - 1991 SN - 3-7701-2512-6 N1 - DuMont-Taschenbücher ; 254 SP - 303 EP - 333 PB - DuMont CY - Köln ER - TY - JOUR A1 - Golland, Alexander A1 - Kriegesmann, Torben ED - Härting, Niko T1 - Der Schutz virtueller Identitäten durch die DSGVO JF - PinG Privacy in Germany N2 - Die Frage des Schutzes von virtuellen Identitäten ist – insbesondere bei Online-Medien – von elementarer Bedeutung: Ihre Beantwortung entscheidet über die Anwendbarkeit des Datenschutzrechts auf vermeintlich anonyme Nutzerprofile im Internet. Eine differenzierte Auseinandersetzung mit der Problematik, ob und unter welchen Umständen virtuelle Identitäten dem Datenschutzrecht unterfallen, fehlt bislang. Der vorliegende Beitrag gibt einen Überblick über den Schutz virtueller Identitäten und zeigt Ansätze auf, mittels derer bestimmt werden kann, wann virtuelle Identitäten nach Inkrafttreten der DSGVO durch das Datenschutzrecht geschützt werden. Y1 - 2017 SN - 2197-1862 U6 - https://doi.org/10.37307/j.2196-9817.2017.02.03 VL - 5 IS - 2 SP - 45 EP - 50 PB - Erich Schmidt Verlag CY - Berlin ER - TY - JOUR A1 - Heuermann, Holger A1 - Schiek, B. T1 - Results of network analyzer measurements with leakage errors-corrected with direct calibration techniques JF - IEEE transactions on instrumentation and measurement : IM / Institute of Electrical and Electronics Engineers, Instrumentation and Measurement Group. 46 (1997), H. 5 Y1 - 1997 SN - 0018-9456 SP - 1120 EP - 1127 ER - TY - JOUR A1 - Finger, Felix A1 - Braun, Carsten A1 - Bil, Cees T1 - Comparative assessment of parallel-hybrid-electric propulsion systems for four different aircraft JF - Journal of Aircraft N2 - Until electric energy storage systems are ready to allow fully electric aircraft, the combination of combustion engine and electric motor as a hybrid-electric propulsion system seems to be a promising intermediate solution. Consequently, the design space for future aircraft is expanded considerably, as serial hybrid-electric, parallel hybrid-electric, fully electric, and conventional propulsion systems must all be considered. While the best propulsion system depends on a multitude of requirements and considerations, trends can be observed for certain types of aircraft and certain types of missions. This Paper provides insight into some factors that drive a new design toward either conventional or hybrid propulsion systems. General aviation aircraft, regional transport aircraft vertical takeoff and landing air taxis, and unmanned aerial vehicles are chosen as case studies. Typical missions for each class are considered, and the aircraft are analyzed regarding their takeoff mass and primary energy consumption. For these case studies, a high-level approach is chosen, using an initial sizing methodology. Only parallel-hybrid-electric powertrains are taken into account. Aeropropulsive interaction effects are neglected. Results indicate that hybrid-electric propulsion systems should be considered if the propulsion system is sized by short-duration power constraints. However, if the propulsion system is sized by a continuous power requirement, hybrid-electric systems offer hardly any benefit. Y1 - 2020 U6 - https://doi.org/10.2514/1.C035897 SN - 1533-3868 VL - 57 IS - 5 PB - AIAA CY - Reston, Va. ER - TY - JOUR A1 - Bongaerts, Johannes A1 - Bovenberg, Roel A1 - Krämer, Marco A1 - Müller, Ulrike A1 - Raeven, Leon A1 - Wubbolts, Marcel T1 - Metabolic engineering to produce fine chemicals in Escherichia coli JF - Chemie - Ingenieur - Technik (CIT) Y1 - 2002 SN - 1522-2640 (E-Journal); 0009-286X (Print) N1 - Printausg. in der Bibliothek vorhanden: 63 ZS 022 VL - Vol. 74 IS - Iss. 5 SP - 694 ER - TY - JOUR A1 - Golland, Alexander ED - Hoeren, Thomas ED - Schneider, Jochen ED - Selmayr, Martin ED - Spies, Axel ED - Wybitul, Tim T1 - Gemeinsam einsam: Ein „Like“ für die gemeinsame Verantwortlichkeit? JF - ZD Zeitschrift für Datenschutz Y1 - 2019 SN - 2192-5593 VL - 9 IS - 9 SP - 381 EP - 382 PB - Beck CY - München ER - TY - JOUR A1 - Bialonski, Stephan A1 - Wellmer, Jörg A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis JF - Epilepsia Y1 - 2006 SN - 0013-9580 VL - 47 SP - 36 ER - TY - JOUR A1 - Ferrein, Alexander A1 - Böhnstedt, Lutz A1 - Lakemeyer, Gerhard T1 - Options in readylog reloaded -- generating decision-theoretic plan libraries in golog / Böhnstedt, Lutz ; Ferrein, Alexander ; Lakemeyer, Gerhard JF - KI 2007: advances in artificial intelligence : 30th Annual German Conference on AI, KI 2007, Osnabrück, Germany, September 10 - 13, 2007 ; proceedings Y1 - 2007 SN - 978-3-540-74564-8 N1 - Lecture Notes in Computer Science ; 4667 SP - 352 EP - 366 PB - Springer CY - Berlin ER - TY - JOUR A1 - Gerigk, M. A1 - Maaß, D. A1 - Takors, Ralf A1 - Kreutzer, A. A1 - Wandrey, Christian A1 - Bongaerts, Johannes A1 - Wubbolts, Marcel T1 - Fermentative Herstellung von L-Phenylalanin im Fed-Batch Verfahren mit E. coli unter Einbindung eines integrierten Aufarbeitungsverfahrens JF - Chemie-Ingenieur-Technik (CIT) Y1 - 2000 SN - 1522-2640 (E-Journal); 0009-286X (Print) N1 - Printausg. in der Bibliothek vorhanden: 63 ZS 022 VL - Vol. 72 IS - Iss. 9 SP - 926 EP - 927 ER - TY - JOUR A1 - Heuermann, Holger T1 - LZY: A Self-Calibration Approach in Competition to the LRM Method for On-Wafer Measurements Y1 - 1995 N1 - 45th ARFTG Conference digest, Spring 1995 : [conference topic: Testing and design of RFIC'S], May 19, 1995, Orange County Convention Center, Orlando, Florida / Automatic RF Techniques Group. Publications chairman: Ed Godshalk; ARFTG Conference digest ; 4 SP - 129 EP - 136 ER - TY - JOUR A1 - Golland, Alexander T1 - Datenschutzrechtliche Fragen personalisierter Preise — Herausforderungen von Algorithmen im Schnittbereich von Ethik, Ökonomie und Datenschutz JF - CR Computer und Recht Y1 - 2020 SN - 2194-4172 U6 - https://doi.org/10.9785/cr-2020-360313 VL - 36 IS - 3 SP - 186 EP - 194 PB - Verlag Dr. Otto Schmidt CY - Köln ER - TY - JOUR A1 - Heuermann, Holger A1 - Stolle, Reinhard A1 - Schiek, Burkhard T1 - Auswertemethoden zur Praezisions-Entfernungsmessung mit FMCW-Systemen und deren Anwendung im Mikrowellenbereich JF - tm - Technisches Messen. 62. 1995 (1995), H. 2 Y1 - 1995 SP - 66 EP - 73 ER - TY - JOUR A1 - Laack, Walter van A1 - Refisch, A. A1 - Ohnsorge, J. A1 - Dürselen, L. T1 - Proximaler Femurteilersatz - Alternative zum Schaftwechsel zementfixierter Hüftendoprothesen JF - Orthopädische Praxis. 20 (1984), H. 11 Y1 - 1984 SN - 0030-588x SP - 856 ER - TY - JOUR A1 - Golland, Alexander T1 - Der räumliche Anwendungsbereich der DS-GVO JF - DuD Datenschutz und Datensicherheit N2 - Die Datenschutz-Grundverordnung (DS-GVO) regelt in ihrem Art. 3 das räumlich anwendbare Datenschutzrecht und zielt dabei gerade auch auf Angebote nichteuropäischer Diensteanbieter ab. Die bisherige Diskussion konzentriert sich bislang in erster Linie darauf, das eingeführte Marktortprinzip zu thematisieren; das weitgehend unangetastete Niederlassungsprinzip und vor allem die Probleme, die sich durch dessen unveränderte Beibehaltung ergeben, werden dagegen nicht erörtert. Der folgende Beitrag versucht sich an einer systematischen Analyse eines teils kontrovers, teils kaum diskutierten Themas. Y1 - 2018 SN - 1862-2607 VL - 42 IS - 6 SP - 351 EP - 357 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Wolf, Martin R. A1 - Foltz, Christian A1 - Schlick, Christopher A1 - Luczak, Holger T1 - Development and evaluation of a groupware system to support chemical design processes / Wolf, Martin ; Foltz, Christian ; Schlick, Christopher ; Luczak, Holger JF - International Journal of Human-Computer Interaction . 14 (2002), H. 2 Y1 - 2002 SN - 1044-7318 SP - 181 EP - 198 PB - - ER - TY - JOUR A1 - Bongaerts, Johannes A1 - Zoschke, Sascha A1 - Weidner, Uwe A1 - Linden, Gottfried T1 - Transcriptional regulation of the proton translocating NADH JF - Molecular microbiology Y1 - 1995 SN - 1365-2958 (E-Journal); 0950-382x (Print) VL - Vol. 16 IS - Iss. 3 SP - 521 EP - 534 ER - TY - JOUR A1 - Staat, Manfred T1 - Problems and Chances for Probabilistic Fracture Mechanics in the Analysis of Steel Pressure Boundary Reliability JF - Technical feasibility and reliability of passive safety systems for nuclear power plants. Proceedings of an Advisory Group Meeting held in Jülich, 21-24 November 1994 Y1 - 1996 N1 - IAEA-TECDOC-920 ; Onlinezugriff erfolgt auf die überarb. Ausg. 2006 SP - 43 EP - 55 CY - Vienna ER - TY - JOUR A1 - Stulpe, Werner T1 - Conditional Expectations, Conditional Distributions, and A Posteriori Ensembles in Generalized Probability Theory JF - International Journal of Theoretical Physics. 27 (1988), H. 5 Y1 - 1988 SN - 1572-9575 SP - 587 EP - 611 ER - TY - JOUR A1 - Laack, Walter van T1 - Allgemeine physiotherapeutische Behandlung nach Hüft- und Kniegelenkoperationen JF - Physiotherapie. 77 (1986), H. 2 Y1 - 1986 SN - 0031-9392 SP - 68 EP - 72 ER - TY - JOUR A1 - Golland, Alexander T1 - Reichweite des “Joint Controllership”: Neue Fragen der gemeinsamen Verantwortlichkeit JF - K&R Kommunikation & Recht N2 - Kein Urteil zum Datenschutzrecht sorgte im vergangenen Jahr für mehr panische Reaktionen als die Entscheidung des EuGH in der Rechtssache “Wirtschaftsakademie Schleswig-Holstein”(C-210/16). Das Urteil warf in datenschutzrechtlicher Literatur und Öffentlichkeit zahlreiche Fragen auf: Ist jetzt jeder “gemeinsam” Verantwortlicher? Was sind die Kriterien? Der EuGH hat kürzlich in einem – dem allgemeinen Vernehmen nach aufsehenerregenden, de facto aber kaum überraschenden – Urteil für Klarheit gesorgt. Dabei hat das Gericht jedoch einige Fragen offengelassen und neue Fragen aufgeworfen. Ein Blick auf alte und neue Herausforderungen in Kooperationsszenarien. Y1 - 2019 SN - 1434-6354 N1 - Zugleich Kommentar zu EuGH, Urteil vom 29. 7. 2019 – C-40/1 VL - 22 IS - 9 SP - 533 EP - 537 PB - dfv Mediengruppe, Deutscher Fachverlag GmbH CY - Frankfurt am Main ER - TY - JOUR A1 - Karschuck, Tobias A1 - Poghossian, Arshak A1 - Ser, Joey A1 - Tsokolakyan, Astghik A1 - Achtsnicht, Stefan A1 - Wagner, Patrick A1 - Schöning, Michael Josef T1 - Capacitive model of enzyme-modified field-effect biosensors: Impact of enzyme coverage JF - Sensors and Actuators B: Chemical N2 - Electrolyte-insulator-semiconductor capacitors (EISCAP) belong to field-effect sensors having an attractive transducer architecture for constructing various biochemical sensors. In this study, a capacitive model of enzyme-modified EISCAPs has been developed and the impact of the surface coverage of immobilized enzymes on its capacitance-voltage and constant-capacitance characteristics was studied theoretically and experimentally. The used multicell arrangement enables a multiplexed electrochemical characterization of up to sixteen EISCAPs. Different enzyme coverages have been achieved by means of parallel electrical connection of bare and enzyme-covered single EISCAPs in diverse combinations. As predicted by the model, with increasing the enzyme coverage, both the shift of capacitance-voltage curves and the amplitude of the constant-capacitance signal increase, resulting in an enhancement of analyte sensitivity of the EISCAP biosensor. In addition, the capability of the multicell arrangement with multi-enzyme covered EISCAPs for sequentially detecting multianalytes (penicillin and urea) utilizing the enzymes penicillinase and urease has been experimentally demonstrated and discussed. KW - Field-effect biosensor KW - Capacitive model KW - Enzyme coverage KW - Multianalyte detection KW - Penicillin Y1 - 2024 U6 - https://doi.org/10.1016/j.snb.2024.135530 SN - 0925-4005 (Print) SN - 1873-3077 (Online) N1 - Corresponding Author: Michael J. Schöning VL - 408 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W.K. T1 - Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard JF - Talanta N2 - Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated. In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.). KW - qNMR KW - Deuterium NMR KW - Deuterated solvents KW - Standardization Y1 - 2021 SN - 0039-9140 U6 - https://doi.org/10.1016/j.talanta.2020.121504 VL - 222 IS - Article number: 121504 PB - Elsevier ER - TY - JOUR A1 - Monakhova, Yulia A1 - Diehl, Bernd W.K. T1 - Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent JF - Journal of Pharmaceutical and Biomedical Analysis N2 - NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products. KW - NMR spectroscopy KW - Inorganic ions KW - Heparin KW - Standardization Y1 - 2022 SN - 0731-7085 U6 - https://doi.org/10.1016/j.jpba.2021.114530 VL - 209 IS - Article number: 114530 PB - Elsevier ER - TY - JOUR A1 - Özsoylu, Dua A1 - Kizildag, Sefa A1 - Schöning, Michael Josef A1 - Wagner, Torsten T1 - Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS) JF - Physics in Medicine N2 - Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO–K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO–K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images. Y1 - 2020 U6 - https://doi.org/10.1016/j.phmed.2020.100030 SN - 2352-4510 VL - 10 IS - 100030 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Pourshahidi, Mohammad Ali A1 - Shalaby, Ahmed A1 - Krause, Hans-Joachim T1 - Probing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation JF - Journal of Magnetism and Magnetic Materials N2 - Biomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application. Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing. Y1 - 2022 U6 - https://doi.org/10.1016/j.jmmm.2022.169965 SN - 0304-8853 VL - 563 IS - In progress, Art. No. 169965 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Achtsnicht, Stefan A1 - Tödter, Julia A1 - Niehues, Julia A1 - Telöken, Matthias A1 - Offenhäusser, Andreas A1 - Krause, Hans-Joachim A1 - Schröper, Florian T1 - 3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection JF - Sensors N2 - For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated. Y1 - 2019 U6 - https://doi.org/10.3390/s19010148 SN - 1424-8220 VL - 19 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Heuermann, Holger A1 - Sadeghfam, Arash T1 - Enhanced system architecture for rugged wide band data transmission / Sadeghfam, A. ; Heuermann, H. JF - European Radar Conference, 2009 : EuRAD 2009 ; Sept. 30 - Oct. 2 2009, Rome, Italy ; part of the European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association Y1 - 2009 SN - 978-2-87487-014-9 N1 - Proceedings of the 6th European Radar Conference SP - 347 EP - 350 PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Trapp, Svenja A1 - Lammers, Tom A1 - Engudar, Gokce A1 - Hoehr, Cornelia A1 - Denkova, Antonia G. A1 - Paulßen, Elisabeth A1 - de Kruijff, Robin M. T1 - Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop JF - EJNMMI Radiopharmacy and Chemistry KW - Microfluidic solvent extraction KW - Ga-68 KW - Cyclotron production KW - Medical radionuclide production KW - Metal contaminants Y1 - 2023 U6 - https://doi.org/10.1186/s41181-023-00195-2 SN - 2365-421X VL - 2023 IS - 8, Article number: 9 SP - 1 EP - 14 PB - Springer Nature ER - TY - JOUR A1 - Engelmann, Ulrich M. A1 - Shalaby, Ahmed A1 - Shasha, Carolyn A1 - Krishnan, Kannan M. A1 - Krause, Hans-Joachim T1 - Comparative modeling of frequency mixing measurements of magnetic nanoparticles using micromagnetic simulations and Langevin theory JF - Nanomaterials N2 - Dual frequency magnetic excitation of magnetic nanoparticles (MNP) enables enhanced biosensing applications. This was studied from an experimental and theoretical perspective: nonlinear sum-frequency components of MNP exposed to dual-frequency magnetic excitation were measured as a function of static magnetic offset field. The Langevin model in thermodynamic equilibrium was fitted to the experimental data to derive parameters of the lognormal core size distribution. These parameters were subsequently used as inputs for micromagnetic Monte-Carlo (MC)-simulations. From the hysteresis loops obtained from MC-simulations, sum-frequency components were numerically demodulated and compared with both experiment and Langevin model predictions. From the latter, we derived that approximately 90% of the frequency mixing magnetic response signal is generated by the largest 10% of MNP. We therefore suggest that small particles do not contribute to the frequency mixing signal, which is supported by MC-simulation results. Both theoretical approaches describe the experimental signal shapes well, but with notable differences between experiment and micromagnetic simulations. These deviations could result from Brownian relaxations which are, albeit experimentally inhibited, included in MC-simulation, or (yet unconsidered) cluster-effects of MNP, or inaccurately derived input for MC-simulations, because the largest particles dominate the experimental signal but concurrently do not fulfill the precondition of thermodynamic equilibrium required by Langevin theory. KW - Magnetic nanoparticles KW - Frequency mixing magnetic detection KW - Langevin theory KW - Micromagnetic simulation KW - Nonequilibrium dynamics Y1 - 2021 SN - 2079-4991 U6 - https://doi.org/10.3390/nano11051257 N1 - This article belongs to the Special Issue Applications and Properties of Magnetic Nanoparticles VL - 11 IS - 5 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - JOUR A1 - Aliazizi, Fereshteh A1 - Özsoylu, Dua A1 - Bakhshi Sichani, Soroush A1 - Khorshid, Mehran A1 - Glorieux, Christ A1 - Robbens, Johan A1 - Schöning, Michael Josef A1 - Wagner, Patrick T1 - Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures JF - Micromachines N2 - In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems. KW - chip-based sensor setup KW - aquaculture KW - microfluidics KW - impedance spectroscopy KW - thermometry KW - electrical conductivity of liquids Y1 - 2024 U6 - https://doi.org/10.3390/mi15060755 SN - 2072-666X N1 - This article belongs to the Special Issue "Multisensor Arrays" N1 - Corresponding author: Michael J. Schöning VL - 15 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kurz, Melanie T1 - Der Modell-Roller JF - Form : the making of design Y1 - 2006 SN - 0015-7678 VL - 2006 IS - 209 SP - 64 EP - 72 ER - TY - JOUR A1 - Zhantlessova, Sirina A1 - Savitskaya, Irina A1 - Kistaubayeva, Aida A1 - Ignatova, Ludmila A1 - Talipova, Aizhan A1 - Pogrebnjak, Alexander A1 - Digel, Ilya T1 - Correction: Zhantlessova et al. advanced “Green” prebiotic composite of bacterial cellulose/pullulan based on synthetic biology-powered microbial coculture strategy. Polymers 2022, 14, 3224 JF - Polymers Y1 - 2024 U6 - https://doi.org/10.3390/polym16131802 SN - 2073-4360 N1 - This article belongs to the Special Issue Cellulose Based Composites VL - 16 IS - 13 PB - MDPI CY - Basel ER - TY - JOUR A1 - Saretzki, Charlotte A1 - Bergmann, Ole A1 - Dahmann, Peter A1 - Janser, Frank A1 - Keimer, Jona A1 - Machado, Patricia A1 - Morrison, Audry A1 - Page, Henry A1 - Pluta, Emil A1 - Stübing, Felix A1 - Küpper, Thomas T1 - Are small airplanes safe with regards to COVID-19 transmission? JF - Journal of Travel Medicine Y1 - 2021 U6 - https://doi.org/10.1093/jtm/taab105 SN - 1708-8305 VL - 28 IS - 7 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Harris, Isaac A1 - Kleefeld, Andreas T1 - Analysis and computation of the transmission eigenvalues with a conductive boundary condition JF - Applicable Analysis N2 - We provide a new analytical and computational study of the transmission eigenvalues with a conductive boundary condition. These eigenvalues are derived from the scalar inverse scattering problem for an inhomogeneous material with a conductive boundary condition. The goal is to study how these eigenvalues depend on the material parameters in order to estimate the refractive index. The analytical questions we study are: deriving Faber–Krahn type lower bounds, the discreteness and limiting behavior of the transmission eigenvalues as the conductivity tends to infinity for a sign changing contrast. We also provide a numerical study of a new boundary integral equation for computing the eigenvalues. Lastly, using the limiting behavior we will numerically estimate the refractive index from the eigenvalues provided the conductivity is sufficiently large but unknown. KW - Boundary integral equations KW - Inverse spectral problem KW - Conductive boundary condition KW - Transmission eigenvalues Y1 - 2020 U6 - https://doi.org/10.1080/00036811.2020.1789598 SN - 1563-504X VL - 101 IS - 6 SP - 1880 EP - 1895 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Bähr, Brigitte T1 - [Gert Hoepner] im Interview zum Thema ; Verpackungspolitik - mehr als Hülle JF - Packaging journal : Technologie, Logistik, Marketing, Produkte Y1 - 2012 SN - 1610-0336 IS - 5 SP - 78 EP - 80 PB - Ella Verlag CY - Hürth ER - TY - JOUR A1 - Kuperjans, Isabel T1 - Exergetische und exergoökonomische Analyse thermischer Prozesse JF - Arbeitsbericht / Institut für Wirtschaftswissenschaften, Rheinisch-Westfälische Technische Hochschule Aachen Y1 - 1996 IS - 06 ER - TY - JOUR A1 - Zhen, Manghao A1 - Liang, Yunpei A1 - Staat, Manfred A1 - Li, Quanqui A1 - Li, Jianbo T1 - Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression JF - Theoretical and Applied Fracture Mechanics N2 - The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress–strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress–strain curves of the fissured sandstone specimens. KW - Constitutive model KW - Damage mechanics theory KW - Discontinuous fractures KW - Uniaxial compression test KW - Non-parallel fissures Y1 - 2024 U6 - https://doi.org/10.1016/j.tafmec.2024.104373 SN - 0167-8442 VL - 131 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Keutmann, Sabine A1 - Staat, Manfred A1 - Laack, Walter van T1 - Untersuchung der thermischen Auswirkung von therapeutischem Ultraschall N2 - Zusammenfassung: In der Orthopädie zählt der therapeutische Ultraschall als Mittel zur Prävention und Therapiebegleitung. Er hat mechanische, thermische und physiko-chemische Auswirkungen auf den menschlichen Körper. Um mehr Erkenntnisse über die thermischen Auswirkungen zu erlangen, wurden Versuche an einem Hydrogel-Phantom und an Probanden durchgeführt. Dabei entstand eine signifikante Erwärmung des Gewebes, welche beim Probandenversuch an der Oberfläche und beim Hydrogelversuch in der Tiefe gemessen wurde. Summary: In orthopaedics, therapeutic ultrasound is a tool of prevention and therapy support. It has mechanical, thermal and physico-chemical effects on the human body. Tests with a hydrogel phantom and with human probands have been performed in order to obtain more knowledge about their thermal effects. Both tests measured temperature increases in cell tissue, on the surface with the human proband test and in depth with the hydrogel phantom test. T2 - Research about the thermal effects of therapeutic ultrasound Y1 - 2018 SN - 2193-5793 SN - 2193-5785 (Druckausgabe) VL - 7 IS - 10 SP - 518 EP - 522 PB - Deutscher Ärzte-Verl. CY - Köln ER - TY - JOUR A1 - Dikta, Gerhard A1 - Reißel, Martin A1 - Harlaß, Carsten T1 - Semi-parametric survival function estimators deduced from an identifying Volterra type integral equation JF - Journal of multivariate analysis N2 - Based on an identifying Volterra type integral equation for randomly right censored observations from a lifetime distribution function F, we solve the corresponding estimating equation by an explicit and implicit Euler scheme. While the first approach results in some known estimators, the second one produces new semi-parametric and pre-smoothed Kaplan–Meier estimators which are real distribution functions rather than sub-distribution functions as the former ones are. This property of the new estimators is particular useful if one wants to estimate the expected lifetime restricted to the support of the observation time. Specifically, we focus on estimation under the semi-parametric random censorship model (SRCM), that is, a random censorship model where the conditional expectation of the censoring indicator given the observation belongs to a parametric family. We show that some estimated linear functionals which are based on the new semi-parametric estimator are strong consistent, asymptotically normal, and efficient under SRCM. In a small simulation study, the performance of the new estimator is illustrated under moderate sample sizes. Finally, we apply the new estimator to a well-known real dataset. KW - Volterra integral equation KW - Product-integration KW - Asymptotic efficiency KW - Semi-parametric random censorship model KW - Censored data KW - Survival analysis Y1 - 2016 U6 - https://doi.org/10.1016/j.jmva.2016.02.008 IS - 147 SP - 273 EP - 284 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Funke, Harald A1 - Esch, Thomas A1 - Roosen, Petra T1 - Antriebssystemanpassungen zur Verwendung von LPG als Flugkraftstoff JF - Motortechnische Zeitschrift (MTZ) N2 - Auch in der allgemeinen Luftfahrt wäre es wünschenswert, die bereits vorhandenen Verbrennungsmotoren mit weniger CO₂-trächtigen Kraftstoffen als dem heute weit verbreiteten Avgas 100LL betreiben zu können. Es ist anzunehmen, dass im Vergleich die unter Normalbedingungen gasförmigen Kraftstoffe CNG, LPG oder LNG deutlich weniger Emissionen produzieren. Erforderliche Antriebssystemanpassungen wurden im Rahmen eines Forschungsprojekts an der FH Aachen untersucht. Y1 - 2022 U6 - https://doi.org/10.1007/s35146-021-0778-2 VL - 2022 IS - 83 SP - 58 EP - 62 PB - Springer Nature CY - Basel ER - TY - JOUR A1 - Michael, Hackl A1 - Mayer, Katharina A1 - Weber, Mareike A1 - Staat, Manfred A1 - van Riet, Roger A1 - Burkhart, Klau Josef A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis JF - The journal of hand surgery Y1 - 2017 U6 - https://doi.org/10.1016/j.jhsa.2017.05.014 SN - 0363-5023 VL - 42 IS - 10 SP - 834.e1 EP - 834.e7 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Salpati, Laurent A1 - Chu, Xiaoyan A1 - Chen, Liangfu A1 - Prasad, Bhagwat A1 - Dallas, Shannon A1 - Evers, Raymond A1 - Mamaril-Fishman, Donna A1 - Geier, Ethan G. A1 - Kehler, Jonathan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Soars, Matthew G. A1 - Unadkat, Jashvant D. A1 - van Waterschoot, Robert A.B. A1 - Yabut, Jocelyn A1 - Schinkel, Alfred H. A1 - Scheer, Nico A1 - Rode, Anja T1 - Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins JF - Drug Metabolism and Disposition N2 - Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography–tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans. Y1 - 2014 U6 - https://doi.org/10.1124/dmd.114.057976 SN - 1521-009X VL - 42 IS - 8 SP - 1301 EP - 1313 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Welden, Melanie A1 - Poghossian, Arshak A1 - Vahidpour, Farnoosh A1 - Wendlandt, Tim A1 - Keusgen, Michael A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers JF - Biosensors N2 - Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1–3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate. KW - urease KW - enzyme-logic gate KW - bi-enzyme biosensor KW - capacitive field-effect sensor KW - tobacco mosaic virus (TMV) KW - penicillinase Y1 - 2022 U6 - https://doi.org/10.3390/bios12010043 SN - 2079-6374 N1 - This article belongs to the Special Issue "Biosensors: 10th Anniversary Feature Papers" VL - 12 IS - 1 PB - MDPI CY - Basel ER - TY - JOUR A1 - Clausnitzer, Julian A1 - Kleefeld, Andreas T1 - A spectral Galerkin exponential Euler time-stepping scheme for parabolic SPDEs on two-dimensional domains with a C² boundary JF - Discrete and Continuous Dynamical Systems - Series B N2 - We consider the numerical approximation of second-order semi-linear parabolic stochastic partial differential equations interpreted in the mild sense which we solve on general two-dimensional domains with a C² boundary with homogeneous Dirichlet boundary conditions. The equations are driven by Gaussian additive noise, and several Lipschitz-like conditions are imposed on the nonlinear function. We discretize in space with a spectral Galerkin method and in time using an explicit Euler-like scheme. For irregular shapes, the necessary Dirichlet eigenvalues and eigenfunctions are obtained from a boundary integral equation method. This yields a nonlinear eigenvalue problem, which is discretized using a boundary element collocation method and is solved with the Beyn contour integral algorithm. We present an error analysis as well as numerical results on an exemplary asymmetric shape, and point out limitations of the approach. KW - Nonlinear eigenvalue problems KW - Boundary integral equations, KW - Exponential Euler scheme, KW - Parabolic SPDEs Y1 - 2024 U6 - https://doi.org/10.3934/dcdsb.2023148 SN - 1531-3492 SN - 1553-524X (eISSN) VL - 29 IS - 4 SP - 1624 EP - 1651 PB - AIMS CY - Springfield ER -