TY - JOUR A1 - Levers, A. A1 - Staat, Manfred A1 - Laack, Walter van T1 - Analysis of the long-term effect of the MBST® nuclear magnetic resonance therapy on gonarthrosis JF - Orthopedic Practice Y1 - 2016 VL - 47 IS - 11 SP - 521 EP - 528 ER - TY - BOOK A1 - Gebhardt, Andreas A1 - Kessler, Julia A1 - Thurn, Laura T1 - 3D-Drucken: Grundlagen und Anwendungen des additive manufacturing (AM) Y1 - 2016 SN - 978-3-446-44672-4 U6 - https://doi.org/10.3139/9783446448452 PB - Hanser CY - München ET - 2., neu bearbeitete und erweiterte Auflage ER - TY - CHAP A1 - Bhattarai, Aroj A1 - Staat, Manfred ED - Erni, Daniel T1 - Female pelvic floor dysfunction: progress weakening of the support system T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The structure of the female pelvic floor (PF) is an inter-related system of bony pelvis,muscles, pelvic organs, fascias, ligaments, and nerves with multiple functions. Mechanically, thepelvic organ support system are of two types: (I) supporting system of the levator ani (LA) muscle,and (II) the suspension system of the endopelvic fascia condensation [1], [2]. Significantdenervation injury to the pelvic musculature, depolimerization of the collagen fibrils of the softvaginal hammock, cervical ring and ligaments during pregnancy and vaginal delivery weakens thenormal functions of the pelvic floor. Pelvic organ prolapse, incontinence, sexual dysfunction aresome of the dysfunctions which increases progressively with age and menopause due toweakened support system according to the Integral theory [3]. An improved 3D finite elementmodel of the female pelvic floor as shown in Fig. 1 is constructed that: (I) considers the realisticsupport of the organs to the pelvic side walls, (II) employs the improvement of our previous FEmodel [4], [5] along with the patient based geometries, (III) incorporates the realistic anatomy andboundary conditions of the endopelvic (pubocervical and rectovaginal) fascia, and (IV) considersvarying stiffness of the endopelvic fascia in the craniocaudal direction [3]. Several computationsare carried out on the presented computational model with healthy and damaged supportingtissues, and comparisons are made to understand the physiopathology of the female PF disorders. Y1 - 2016 U6 - https://doi.org/10.17185/duepublico/40821 SP - 11 EP - 12 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Kahmann, Stephanie A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Müller, Lars-Peter A1 - Staat, Manfred ED - Erni, Daniel T1 - Impact of a proximal radial shortening osteotomy on the distribution of forces and the stability of the elbow T2 - 1st YRA MedTech Symposium 2016 : April 8th / 2016 / University of Duisburg-Essen N2 - The human arm consists of the humerus (upper arm), the medial ulna and the lateral radius (forearm). The joint between the humerus and the ulna is called humeroulnar joint and the joint between the humerus and the radius is called humeroradial joint. Lateral and medial collateral ligaments stabilize the elbow. Statistically, 2.5 out of 10,000 people suffer from radial head fractures [1]. In these fractures the cartilage is often affected. Caused by the injured cartilage, degenerative diseases like posttraumatic arthrosis may occur. The resulting pain and reduced range of motion have an impact on the patient’s quality of life. Until now, there has not been a treatment which allows typical loads in daily life activities and offers good long-term results. A new surgical approach was developed with the motivation to reduce the progress of the posttraumatic arthrosis. Here, the radius is shortened by 3 mm in the proximal part [2]. By this means, the load of the radius is intended to be reduced due to a load shift to the ulna. Since the radius is the most important stabilizer of the elbow it has to be confirmed that the stability is not affected. In the first test (Fig. 1 left), pressure distributions within the humeroulnar and humeroradial joints a native and a shortened radius were measured using resistive pressure sensors (I5076 and I5027, Tekscan, USA). The humerus was loaded axially in a tension testing machine (Z010, Zwick Roell, Germany) in 50 N steps up to 400 N. From the humerus the load is transmitted through both the radius and the ulna into the hand which is fixed on the ground. In the second test (Fig. 1 right), the joint stability was investigated using a digital image correlation system to measure the displacement of the ulna. Here, the humerus is fixed with a desired flexion angle and the unconstrained forearm lies on the ground. A rope connects the load actuator with a hook fixed in the ulna. A guide roller is used so that the rope pulls the ulna horizontally when a tensile load is applied. This creates a moment about the elbow joint with a maximum value of 7.5 Nm. Measurements were performed with varying flexion angles (0°, 30°, 60°, 90°, 120°). For both tests and each measurement, seven specimens were used. Student ́s t-test was employed to determine whether the mean values of the measurements in native specimen and operated specimens differ significantly. Y1 - 2016 U6 - https://doi.org/10.17185/duepublico/40821 SP - 7 EP - 8 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Teixeira Boura, Cristiano José A1 - Niederwestberg, Stefan A1 - McLeod, Jacqueline A1 - Herrmann, Ulf A1 - Hoffschmidt, Bernhard T1 - Development of heat exchanger for high temperature energy storage with bulk materials T2 - AIP Conference Proceedings Y1 - 2016 U6 - https://doi.org/10.1063/1.4949106 VL - 1734 IS - 1 SP - 050008-1 EP - 050008-7 ER - TY - CHAP A1 - Krause, Thomas A1 - Oettel, Britta T1 - Baumaschinen T2 - Zahlentafeln für den Baubetrieb N2 - Die Leistungsermittlung und Bemessung von Baumaschinen für die folgenden Bereiche werden bearbeitet: Maschinen für den Betonbau, Hebezeuge, Maschinen für den Erdbau, Straßenbaumaschinen, Rückbaugeräte und Elemente der Baustelleneinrichtung Y1 - 2016 SN - 978-3-658-02838-1 (Online) SN - 978-3-658-02837-4 (Print) U6 - https://doi.org/10.1007/978-3-658-02838-1_9 SP - 1069 EP - 1163 PB - Springer Vieweg CY - Wiesbaden ET - 9., überarb. und aktual. Aufl. ER - TY - CHAP A1 - Martin, Joachim A1 - Martin, Angelika T1 - Größen, Formeln, Bemessung T2 - Zahlentafeln für den Baubetrieb N2 - Das Kapitel 1 vermittelt eine Übersicht für den schnellen Gebrauch von Größen, Einheiten und Zeichen. Es folgt die Darstellung wichtiger Grundlagen der Mathematik, Lastannahmen und einfacher statischer Systeme. Schließlich werden Hinweise zu charakteristischen Festigkeiten und Tragfähigkeitsnachweisen für Berechnungen im Mauerwerk, Holz- und Stahlbau sowie Stahlbetonbau gegeben. Für eine weitere Vertiefung des Themas empfiehlt sich der Wendehorst Bautechnische Zahlentafel Y1 - 2016 SN - 978-3-658-02838-1 (Online) SN - 978-3-658-02837-4 (Print) U6 - https://doi.org/10.1007/978-3-658-02838-1_1 SP - 1 EP - 61 PB - Springer Vieweg CY - Wiesbaden ET - 9., überarb. und aktual. Aufl. ER - TY - CHAP A1 - Stollenwerk, Dominik A1 - Rieke, Christian A1 - Dahmen, Markus A1 - Pieper, Martin T1 - Biogas Production Modelling : A Control System Engineering Approach T2 - IOP Conference Series: Earth and Environmental Science. Bd. 32 Y1 - 2016 U6 - https://doi.org/10.1088/1755-1315/32/1/012008 SN - 1755-1315 N1 - ICARET 2016, International Conference on Advances in Renewable Energy and Technologies, Putrajaya, MY, Feb 23-25, 2016 SP - 012008/1 EP - 012008/4 ER - TY - CHAP A1 - König, Johannes Alexander A1 - Wolf, Martin R. ED - Stephanidis, C. T1 - The pyramid assessment framework for ‘competence developing games’ T2 - Communications in Computer and Information Science Y1 - 2016 SN - 978-331940541-4 U6 - https://doi.org/10.1007/978-3-319-40542-1_37 SN - 1865-0929 N1 - 18th International Conference on Posters’ Extended Abstracts, HCI International 2016; Toronto; Canada; 17 July 2016 through 22 July 2016 VL - 618 SP - 232 EP - 237 PB - Springer ER - TY - JOUR A1 - Roth, Jasmine A1 - Tippkötter, Nils T1 - Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium JF - Cellulose Chemistry and Technology N2 - Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹. Y1 - 2016 VL - 50 IS - 3-4 SP - 405 EP - 410 PB - Editura Academiei Romane CY - Bukarest ER - TY - BOOK A1 - Krause, Thomas A1 - Ulke, Bernd ED - Krause, Thomas ED - Ulke, Bernd T1 - Zahlentafeln für den Baubetrieb Y1 - 2016 SN - 978-3-658-02838-1 U6 - https://doi.org/10.1007/978-3-658-02838-1 PB - Springer Fachmedien CY - Wiesbaden ET - 9., überarb. und aktual. Aufl. ER - TY - JOUR A1 - Steinbauer, Gerald A1 - Ferrein, Alexander T1 - 20 Years of RoboCup JF - KI - Künstliche Intelligenz Y1 - 2016 U6 - https://doi.org/10.1007/s13218-016-0442-z SN - 1610-1987 VL - 30 IS - 3-4 SP - 221 EP - 224 PB - Springer CY - Berlin ER - TY - GEN A1 - Engel, M. A1 - Tippkötter, Nils T1 - Einfluss eines Phenazin-Mediators und elektrischen Potenzials auf die Aceton-Butanol-Ethanol-Fermentation T2 - Chemie Ingenieur Technik N2 - In den letzten Jahren haben nachhaltige, biotechnologische Prozesse zunehmend an Bedeutung gewonnen. Die Aceton-Butanol-Ethanol-Fermentation (ABE-Fermentation) mit dem anaeroben Bakterium Clostridium acetobutylicum zur Gewinnung von Biobutanol könnte in diesem Zusammenhang eine Möglichkeit der nachhaltigen Kraftstoffproduktion darstellen. In dieser Arbeit wird der Einfluss zusätzlich verfügbarer Elektronen durch den Einsatz des Phenazin-Farbstoffs Neutralrot als Redoxmediator sowie das Anlegen eines elektrischen Potenzials während der ABE-Fermentation untersucht. Es wird gezeigt, dass das Neutralrot keinen Einfluss auf die Leerlaufspannung von ca. 500 mV vs. Ag/AgCl während der Fermentation hat. Der Mediator bewirkt allerdings eine frühere Butanolbildung sowie höhere Butanolkonzentrationen. Wird zudem die Mediatorkonzentration von 125 mM auf 250 mM angehoben, wird dabei auch die maximale Butanolkonzentration um 36 % ± 1,8 % innerhalb von28 Stunden gesteigert. Y1 - 2016 U6 - https://doi.org/10.1002/cite.201650105 SN - 0009-286X SN - 1522-2640 (eISSN) N1 - ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen VL - 88 IS - 9 SP - 1254 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Stephan, Achim A1 - Heuermann, Holger A1 - Prantner, Michael T1 - Cutting human tissue with novel atmospheric-pressure microwave plasma jet T2 - 46th European Microwave Conference (EuMC) Y1 - 2016 SN - 978-2-87487-043-9 U6 - https://doi.org/10.1109/EuMC.2016.7824490 SP - 902 EP - 905 PB - IEEE ER - TY - CHAP A1 - Streit, Wilfried T1 - Kalkulation T2 - Zahlentafeln für den Baubetrieb N2 - Das Kapitel behandelt die Kosten- und Preisermittlung, die Kostenvorgabe und Kostenkontrolle. Der Angebotspreis wird aufgeschlüsselt in die Einzelkosten der Teilleistungen, die Baustellengemeinkosten, die Allgemeinen Geschäftskosten und einen Zuschlag für Wagnis und Gewinn. Auf der Basis der Angebotskalkulation werden die Vorgaben für die Kostenkontrolle entwickelt. Y1 - 2016 SN - 978-3-658-02838-1 (Online) SN - 978-3-658-02837-4 (Print) U6 - https://doi.org/10.1007/978-3-658-02838-1_13 SP - 1391 EP - 1501 PB - Springer Vieweg CY - Wiesbaden ET - 9., überarb. und aktual. Aufl. ER - TY - JOUR A1 - Goßmann, Matthias A1 - Frotscher, Ralf A1 - Linder, Peter A1 - Bayer, Robin A1 - Epple, U. A1 - Staat, Manfred A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells JF - Cellular physiology and biochemistry N2 - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential. KW - Inotropic compounds KW - Pharmacology KW - Ion channels KW - CellDrum KW - Heart tissue culture KW - Induced pluripotent stem cells KW - Cardiac myocytes Y1 - 2016 U6 - https://doi.org/10.1159/000443124 SN - 1421-9778 (Online) SN - 1015-8987 (Print) VL - 38 IS - 3 SP - 1182 EP - 1198 PB - Karger CY - Basel ER - TY - GEN A1 - Wulfhorst, H. A1 - Merseburg, J. A1 - Tippkötter, Nils T1 - Batteriekomponenten aus nachwachsenden Rohstoffen T2 - Chemie Ingenieur Technik N2 - In diesem Beitrag geht es um die Integration von Stoffströmen einer Lignocellulose-Bioraffinerie in Verfahren zur Batterieherstellung. Pflanzliche Reststoffe aus der Biokraftstoffherstellung wie Lignin sollen zur Herstellung neuer Batteriematerialien verwendet werden. Hierbei wird das Lignin als Matrix für die vorgraphitischen C-haltigen Einlagerungsverbindungen in den Elektroden genutzt. Die Si-C-Komposite werden durch das Einbetten von Si in eine Ligninmatrix mit anschließender Carbonisierung hergestellt. Das Lignin hierfür wird durch die sequentielle hydrothermale Vorbehandlung von Buchenholz bei variablen Bedingungen gewonnen und mit Si-Nanopartikel sowie als Referenz ohne Si-Nanopartikel gefällt. Die Ergebnisse zeigen, dass die sequenzielle Vorbehandlung höhere Ausbeuten im Vergleich zum LHW- oder Organosolv-Aufschluss liefert. Um eine Anode herzustellen, wurde das resultierende Si–C-Kompositmaterial carbonisiert, auf einen Stromsammler aufgetragen und elektro-chemisch charakterisiert. Der Einfluss der Vorbehandlungsschritte auf den Herstellungsprozess und die ökonomische Bewertung des untersuchten Bioraffinerie-Prozesses wurde mithilfe eines Stoffstrommodells analysiert. Y1 - 2016 U6 - https://doi.org/10.1002/cite.201650333 SN - 0009-286X SN - 1522-2640 (eISSN) N1 - ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen VL - 88 IS - 9 SP - 1234 EP - 1235 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Laack, Walter van T1 - Schnittstelle Tod: Wo stehen wir nach 40 Jahren NTE-Forschung? Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:101:1-201603132912 SN - 978-3-936624-30-4 (Print-Ausgabe) SN - 978-3-936624-32-8 (Online-Ausgabe) N1 - Tagungsbeiträge des 4. Europäischen Seminars am 07. November 2015 in Aachen zum Thema Nahtoderfahrungen mit dem Serientitel: "Schnittstelle Tod" PB - van Laack GmbH CY - Aachen ER - TY - GEN A1 - Roth, J. A1 - Tippkötter, Nils T1 - New Approach for Enzymatic Hydrolysis of Lignocellulose with Selective Diffusion Separation of the Monosaccharide Products T2 - Chemie Ingenieur Technik N2 - Enzymatic hydrolysis of lignocellulosic material plays an important role in the classical biorefinery approach. Apart from the pretreatment of the raw material, hydrolysis is the basis for the conversion of the cellulose and hemicellulose fraction into fermentable sugars. After hydrolysis, usually a solid-liquid separation takes place, in order to separate the residual plant material from the sugar-rich fraction, which can be subsequently used in a fermentation step. In order to factor out the separation step, the usage of in alginate immobilized crude cellulose fiber beads (CFBs) were evaluated. Pretreated cellulose fibers are incorporated in an alginate matrix together with the relevant enzymes. In doing so, sugars diffuse trough the alginate matrix, allowing a simplified delivery into the surrounding fluid. This again reduces product inhibition of the glucose on the enzyme catalysts. By means of standardized bead production the hydrolysis in lab scale was possible. First results show that liberation of glucose and xylose is possible, allowing a maximum total sugar yield of 75 %. Y1 - 2016 U6 - https://doi.org/10.1002/cite.201650301 SN - 0009-286X SN - 1522-2640 (eISSN) N1 - ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen VL - 88 IS - 9 SP - 1237 PB - Wiley-VCH CY - Weinheim ER - TY - GEN A1 - Capitain, C. A1 - Hering, T. A1 - Tippkötter, Nils T1 - Enzymatische Polymerisation von Ligninmodellkomponenten und Organosolv-Lignin mit aromatischen Aminosäuren T2 - Chemie Ingenieur Technik N2 - Die stoffliche Nutzung von Lignin aus Bioraffinerien ist ein wichtiger Bestandteil für den Wertschöpfungsprozess von nachwachsenden, pflanzlichen Rohstoffen. Lignin zählt zu den wenigen erneuerbaren Quellen für phenolische Bestandteile, wird aber derzeit meist nur thermisch verwertet. Ziel dieses Forschungsvorhabens ist die Funktionalisierung von Lignin zur Verbesserung der Adhäsionseigenschaften. Als funktionelle Gruppe wird die aromatische Aminosäure L-DOPA verwendet, die charakteristisch für die Adhäsionskraft von Muscheln ist. Lignin ist ein geeignetes Stützgerüst, da es ein Polymer ist, das durch enzymkatalysierte Polymerisation gebildet wird. Essenziell für die Entwicklung ist ein besseres Verständnis über die Bildung von Lignin-Polymeren und deren verschiedene Eigenschaften. Um die Einflussfaktoren auf Kettenlänge und Polymerisationseffizienz zu untersuchen, werden zurzeit sowohl Ligninmodellkomponenten (LMK) als auch gelöstes Organosolv-Lignin verwendet. Laufende Untersuchungen werden zeigen, ob sich die enzymatische Polymerisationsreaktion auf ein gelöstes Ligninpolymer aus einem Organosolv-Aufschluss übertragen lässt. Y1 - 2016 U6 - https://doi.org/10.1002/cite.201650374 SN - 0009-286X SN - 1522-2640 (eISSN) N1 - ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen VL - 88 IS - 9 SP - 1236 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Tippkötter, Nils ED - Kaltschmidt, Martin T1 - Grundlagen der bio-chemischen Umwandlung T2 - Energie aus Biomasse : Grundlagen, Techniken und Verfahren Y1 - 2016 SN - 978-3-662-47437-2 (Print) SN - 978-3-662-47438-9 (Online) U6 - https://doi.org/10.1007/978-3-662-47438-9 SP - 1447 EP - 1500 PB - Springer Vieweg CY - Berlin ; Heidelberg ET - 3., aktualisierte, erweiterte Auflage ER - TY - GEN A1 - Kuthan, K. A1 - Al-Kaidy, H. A1 - Tippkötter, Nils T1 - Tropfenbasierte Enzymreaktionen auf Glasoberflächen im μL-Maßstab mit ortsaufgelöster pL-Dosierung der Reaktanden T2 - Chemie Ingenieur Technik N2 - Mit der Entwicklung wässriger Tropfen, die mit einer schützenden Hülle magnetisierbarer, hydrophober Partikel umgeben sind, ergeben sich neue Möglichkeiten im Bereich der Mikrofluidik. So können die Tropfen als flüssige Mikroreaktoren eingesetzt werden. Der wässrige Kern dieser Mikroreaktoren besteht aus einer Substratlösung für enzymatische Umsetzungen. Durch Bewegen der Mikroreaktoren können diese über immobilisierten Enzymen positioniert werden, um so einen enzymatischen Umsatz innerhalb der Mikroreaktoren zu realisieren. Hierfür wurde eine neue Mikroreaktorplattform-Technologie etabliert. Die Mikroreaktoren können aufgrund ihrer magnetisierbaren Hüllenpartikel über elektromagnetische Spulen bewegt werden. Die Bewegung erfolgt dabei mit einer automatisierten Aktuatorplattform, bestehend aus einer 3x3 Doppelspulenmatrix mit Magnetkernen. Als modellhaftes Reaktionssystem wird eine Enzymkaskade eingesetzt, die sich aus einer b-Glucosidase, Glucose-Oxidase und Meerrettichperoxidase zusammensetzt. Primär untersuchte Substrate sind Fluorescein-di-b-D-glucopyranoside, und 1-(3,7-Dihydroxy-10H-phenoxazin-10-yl)-ethanon, bei deren Umsatz fluoreszierende Produkte entstehen. Y1 - 2016 U6 - https://doi.org/10.1002/cite.201650117 N1 - ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen VL - 88 IS - 9 SP - 1336 EP - 1337 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Rajan, Sreelakshmy A1 - Kubalski, Thomas A1 - Altay, Okyay A1 - Dalguer, Luis A A1 - Butenweg, Christoph T1 - Multi-dimensional fragility analysis of a RC building with components using response surface method T2 - 24th International Conference on Structural Mechanics in Reactor Technology, Busan, Korea, 20-25 August, 2017 N2 - Conventional fragility curves describe the vulnerability of the main structure under external hazards. However, in complex structures such as nuclear power plants, the safety or the risk depends also on the components associated with a system. The classical fault tree analysis gives an overall view of the failure and contains several subsystems to the main event, however, the interactions in the subsystems are not well represented. In order to represent the interaction of the components, a method suggested by Cimellaro et al. (2006) using multidimensional performance limit state functions to obtain the system fragility curves is adopted. This approach gives the possibility of deriving the cumulative fragility taking into account the interaction of the response of different components. In this paper, this approach is used to evaluate seismic risk of a representative electrical building infrastructure, including the component, of a nuclear power plant. A simplified model of the structure, with nonlinear material behavior is employed for the analysis in Abaqus©. The input variables considered are the material parameters, boundary conditions and the seismic input. The variability of the seismic input is obtained from selected ground motion time histories of spectrum compatible synthetic ccelerograms. Unlike the usual Monte Carlo methods used for the probabilistic analysis of the structure, a computationally effective response surface method is used. This method reduces the computational effort of the calculations by reducing the required number of samples. Y1 - 2017 SN - 9781510856776 SP - 3126 EP - 3135 PB - International Assn for Structural Mechanics in Reactor Technology (IASMiRT) CY - Raleigh, USA ER - TY - CHAP A1 - Bung, Daniel Bernhard A1 - Valero, Daniel T1 - FlowCV - An open-source toolbox for computer vision applications in turbulent flows T2 - Proceedings of the 37th IAHR World Congress August 13 – 18, 2017, Kuala Lumpur, Malaysia Y1 - 2017 SN - 2521-716X SP - 5356 EP - 5365 ER - TY - JOUR A1 - Peloni, Alessandro A1 - Dachwald, Bernd A1 - Ceriotti, Matteo T1 - Multiple near-earth asteroid rendezvous mission: Solar-sailing options JF - Advances in Space Research Y1 - 2017 U6 - https://doi.org/10.1016/j.asr.2017.10.017 SN - 0273-1177 IS - In Press, Corrected Proof PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Funke, Harald A1 - Beckmann, Nils A1 - Abanteriba, Sylvester T1 - A comparison of complex chemistry mechanisms for hydrogen methane blends based on the Sandia / Sydney Bluff-Body Flame HM1 T2 - Proceedings of the Eleventh Asia‐Pacific Conference on Combustion (ASPACC 2017), New South Wales, Australia, 10-14 December 2017 Y1 - 2017 SN - 978-1-5108-5646-2 SP - 262 EP - 265 ER - TY - CHAP A1 - Boesen, Niklas A1 - Rosin, Julia A1 - Butenweg, Christoph A1 - Deichsel, Anne A1 - Klinkel, Sven ED - Zabel, Volkmar ED - Beinersdorf, Silke T1 - Untersuchung vorhandenerTragreserven moderner unbewehrter Mauerwerksbauten T2 - Vortragsband der 15. D-A-CH-Tagung Erdbebeningenieurwesen und Baudynamik Y1 - 2017 SN - 978-3-930108-13-5 N1 - 21.-22. September 2017, Weimar. ISBN laut DNB falsch SP - 408 EP - 418 PB - Deutsche Gesellschaft für Erdbebeningenieurwesen und Baudynamik (DGEB) e.V. CY - Weimar ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Biele, Jens A1 - Dachwald, Bernd A1 - Grimm, Christian D. A1 - Lange, Caroline A1 - Ulamec, Stephan A1 - Ziach, Christian A1 - Spröwitz, Tom A1 - Ruffer, Michael A1 - Seefeldt, Patric A1 - Spietz, Peter A1 - Toth, Norbert A1 - Mimasu, Yuya A1 - Rittweger, Andreas A1 - Bibring, Jean-Pierre A1 - Braukhane, Andy A1 - Boden, Ralf Christian A1 - Dumont, Etienne A1 - Jahnke, Stephan Siegfried A1 - Jetzschmann, Michael A1 - Krüger, Hans A1 - Lange, Michael A1 - Gomez, Antonio Martelo A1 - Massonett, Didier A1 - Okada, Tatsuaki A1 - Sagliano, Marco A1 - Sasaki, Kaname A1 - Schröder, Silvio A1 - Sippel, Martin A1 - Skoczylas, Thomas A1 - Wejmo, Elisabet T1 - Small landers and separable sub-spacecraft for near-term solar sails T2 - The Fourth International Symposium on Solar Sailing 2017 N2 - Following the successful PHILAE landing with ESA's ROSETTA probe and the launch of the MINERVA rovers and the Mobile Asteroid Surface Scout, MASCOT, aboard the JAXA space probe, HAYABUSA2, to asteroid (162173) Ryugu, small landers have found increasing interest. Integrated at the instrument level in their mothership they support small solar system body studies. With efficient capabilities, resource-friendly design and inherent robustness they are an attractive exploration mission element. We discuss advantages and constraints of small sub-spacecraft, focusing on emerging areas of activity such as asteroid diversity studies, planetary defence, and asteroid mining, on the background of our projects PHILAE, MASCOT, MASCOT2, the JAXA-DLR Solar Power Sail Lander Design Study, and others. The GOSSAMER-1 solar sail deployment concept also involves independent separable sub-spacecraft operating synchronized to deploy the sail. Small spacecraft require big changes in the way we do things and occasionally a little more effort than would be anticipated based on a traditional large spacecraft approach. In a Constraints-Driven Engineering environment we apply Concurrent Design and Engineering (CD/CE), Concurrent Assembly, Integration and Verification (CAIV) and Model-Based Systems Engineering (MBSE). Near-term solar sails will likely be small spacecraft which we expect to harmonize well with nano-scale separable instrument payload packages. KW - Small Solar System Body Lander KW - Small Spacecraft KW - PHILAE KW - MASCOT KW - Solar Power Sail Y1 - 2017 N1 - The Fourth International Symposium on Solar Sailing 2017, 17-20 January 2017. Kyoto Research Park, Kyoto, Japan SP - 1 EP - 10 ER - TY - JOUR A1 - Giresini, Linda A1 - Sassu, Mauro A1 - Butenweg, Christoph A1 - Alecci, Valerio A1 - De Stefano, Mario T1 - Vault macro-element with equivalent trusses in global seismic analyses JF - Earthquakes and Structures N2 - This paper proposes a quick and simplified method to describe masonry vaults in global seismic analyses of buildings. An equivalent macro-element constituted by a set of six trusses, two for each transverse, longitudinal and diagonal direction, is introduced. The equivalent trusses, whose stiffness is calculated by fully modeled vaults of different geometry, mechanical properties and boundary conditions, simulate the vault in both global analysis and local analysis, such as kinematic or rocking approaches. A parametric study was carried out to investigate the influence of geometrical characteristics and mechanical features on the equivalent stiffness values. The method was numerically validated by performing modal and transient analysis on a three naves-church in the elastic range. Vibration modes and displacement time-histories were compared showing satisfying agreement between the complete and the simplified models. This procedure is particularly useful in engineering practice because it allows to assess, in a simplified way, the effectiveness of strengthening interventions for reducing horizontal relative displacements between vault supports. KW - vault KW - macro-element KW - equivalent stiffness KW - truss KW - churches Y1 - 2017 U6 - https://doi.org/10.12989/eas.2017.12.4.409 SN - 2092-7614 (Print) SN - 2092-7622 (Online) VL - 12 IS - 4 SP - 409 EP - 423 PB - Techno-Press CY - Taejŏn ER - TY - JOUR A1 - Kerpen, Nils B. A1 - Bung, Daniel Bernhard A1 - Valero, Daniel A1 - Schlurmann, Torsten T1 - Energy dissipation within the wave run-up at stepped revetments JF - Journal of Ocean University of China Y1 - 2017 U6 - https://doi.org/10.1007/s11802-017-3355-z SN - 1993-5021 VL - 16 IS - 4 SP - 649 EP - 654 PB - Springer CY - Berlin ER - TY - CHAP A1 - Butenweg, Christoph A1 - Marinković, Marko A1 - Kubalski, Thomas A1 - Fehling, Ekkehard A1 - Pfetzing, Thomas A1 - Meyer, Udo ED - Zabel, Volkmar ED - Beinersdorf, Silke T1 - Innovative Ansätze für die seismische Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk T2 - Vortragsband der 15. D-A-CH-Tagung Erdbebeningenieurwesen und Baudynamik KW - Stahlbetonrahmen KW - Ausfachungsmauerwerk KW - INSYSME KW - Erdbeben KW - Ziegelmauerwerk Y1 - 2017 SN - 978-3-930108-13-5 SP - 130 EP - 145 PB - Deutsche Gesellschaft für Erdbebeningenieurwesen und Baudynamik (DGEB) e.V. CY - Weimar ER - TY - CHAP A1 - Grundmann, Jan Thimo A1 - Meß, Jan-Gerd A1 - Biele, Jens A1 - Seefeldt, Patric A1 - Dachwald, Bernd A1 - Spietz, Peter A1 - Grimm, Christian D. A1 - Spröwitz, Tom A1 - Lange, Caroline A1 - Ulamec, Stephan T1 - Small spacecraft in small solar system body applications T2 - IEEE Aerospace Conference 2017, Big Sky, Montana, USA Y1 - 2017 SN - 978-1-5090-1613-6 U6 - https://doi.org/10.1109/AERO.2017.7943626 SP - 1 EP - 20 ER - TY - JOUR A1 - Wolisz, Henryk A1 - Schütz, Thomas A1 - Blanke, Tobias A1 - Hagenkamp, Markus A1 - Kohrn, Markus A1 - Wesseling, Mark A1 - Müller, Dirk T1 - Cost optimal sizing of smart buildings' energy system components considering changing end-consumer electricity markets JF - Energy Y1 - 2017 U6 - https://doi.org/10.1016/j.energy.2017.06.025 VL - 137 SP - 715 EP - 728 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Butenweg, Christoph A1 - Rosin, Julia A1 - Holler, Stefan T1 - Analysis of cylindrical granular material silos under seismic excitation JF - Buildings N2 - Silos generally work as storage structures between supply and demand for various goods, and their structural safety has long been of interest to the civil engineering profession. This is especially true for dynamically loaded silos, e.g., in case of seismic excitation. Particularly thin-walled cylindrical silos are highly vulnerable to seismic induced pressures, which can cause critical buckling phenomena of the silo shell. The analysis of silos can be carried out in two different ways. In the first, the seismic loading is modeled through statically equivalent loads acting on the shell. Alternatively, a time history analysis might be carried out, in which nonlinear phenomena due to the filling as well as the interaction between the shell and the granular material are taken into account. The paper presents a comparison of these approaches. The model used for the nonlinear time history analysis considers the granular material by means of the intergranular strain approach for hypoplasticity theory. The interaction effects between the granular material and the shell is represented by contact elements. Additionally, soil–structure interaction effects are taken into account. KW - granular silo KW - earthquake engineering KW - hypoplasticity KW - nonlinear transient analyses Y1 - 2017 U6 - https://doi.org/10.3390/buildings7030061 SN - 2075-5309 VL - 7 IS - 3 SP - 1 EP - 12 PB - MDPI CY - Basel ER - TY - JOUR A1 - Steuer-Dankert, Linda A1 - Sharma, Mamta Rameshwarlal A1 - Bleck, Wolfgang A1 - Leicht-Scholten, Carmen T1 - Diversity and innovation management in large research groups JF - International Journal of Innovation Management N2 - Contemporary research appreciates a diverse workforce as a potential source of innovation. Researchers explore the fine details of why diversity management is central for generating innovations in heterogeneous research groups and how it could be effectively implemented into organizations. Complex research associations that discuss topics with a high impact on society increasingly address the necessity of establishing a diverse workforce to confront the challenges of tomorrow. Characterized by complex management structures as well as hierarchies, research associations have not been a subject of investigation until now. For this reason, the presented research project aims to develop a diversity and innovation management strategy with the ultimate goal of inducing change in the corporate culture. The proposed approach consisted of six phases; the first two phases investigated the status quo of diversity in the existing organizational structures of member institutes and the variety of particular working cultures within the research association. The third and the fourth phases utilized qualitative and quantitative studies. The third phase focused on the connection of management level to diversity and innovation, and the need for diversity and innovation management, and tailor-made methods of implementing them. The first three phases have been accomplished successfully; preliminary results are already available. The fourth phase will mainly focus on exploring the mind-set of the employees. The fifth phase will consolidate the findings in the first four phases into an implementable strategy. The final phase will address the implementation of this strategy into the organization. Phases 4 to 6 have not yet been undertaken KW - diversity management KW - innovation management KW - research association KW - change management KW - engineering Y1 - 2017 SN - 1757-5877 VL - 5 IS - 2 SP - 49 EP - 72 ER - TY - CHAP A1 - Steuer-Dankert, Linda A1 - Leicht-Scholten, Carmen T1 - Innovation and Diversity : Integrating new perspectives into research associations T2 - 12th European Conference on Innovation and Entrepreneurship (ECIE 2017) : Paris, France, 21-22 September 2017 N2 - The link between diversity and innovation is broadly discussed in the context of research and innovation processes. Many institutions and enterprises, specifically in commerce, have already tried to establish sustainable diversity management concepts, in order to increase the diversity of their workforce in addition to establishing a corporate culture of openness. Alongside the creation of a working place where different experiences and skills are valued equally, the entrepreneurial intention is to transfer diversity into economically relevant advantages. Taking into account the potential of diversity in research and innovation processes, the project “Diversity- and Innovation Management” was incorporated within a large interdisciplinary research Cluster. The project’s purpose was to study the context between diversity and innovation in research associations and to later develop a customised management concept into an interdisciplinary research Cluster on integrative production technology with full integration. The challenge of such research associations lays in an organisational structure which is often described as being decentralised. Researchers coming from different academic disciplines, while having diverse habits, conduct research on large scientific issues and challenges. In addition, these researchers are socialised in different institutions and university chairs. Theses differences in leadership styles, business cultures and organisational strategies, follow into their research team work. Taking a closer look into the management of human resources suggests that decentral organised recruitment processes, as well as allocation of human resources, lead to a lacking overview in regard to missing competencies, perspectives and backgrounds in research networks. These circumstances are comparable to big corporate groups. While developing a management concept for research associations, these characteristics must be considered. To ensure this, the project follows a human-centred approach, which considers top-down, as well as bottom-up perspectives. This paper presents the applied mixed-method approach in the scientific issue described above. In the frame of the Cluster of Excellence “Integrative Production Technology for High-Wage Countries” research results based on quantitative, as well as qualitative studies, were presented as an application example. This paper provides a new perspective on the innovation and diversity context. Against the background of complex research organisations, the development approach of a management concept is particularly interesting. KW - Innovation KW - Diversity KW - Innovation Management KW - Diversity Management KW - Leadership Y1 - 2017 SN - 978-1-911218-54-8 SP - 767 EP - 776 ER - TY - CHAP A1 - Peloni, Alessandro A1 - Dachwald, Bernd A1 - Ceriotti, Matteo T1 - Multiple NEA rendezvous mission: Solar sailing options T2 - Fourth International Symposium on Solar Sailing N2 - The scientific interest in near-Earth asteroids (NEAs) and the classification of some of those as potentially hazardous asteroid for the Earth stipulated the interest in NEA exploration. Close-up observations of these objects will increase drastically our knowledge about the overall NEA population. For this reason, a multiple NEA rendezvous mission through solar sailing is investigated, taking advantage of the propellantless nature of this groundbreaking propulsion technology. Considering a spacecraft based on the DLR/ESA Gossamer technology, this work focuses on the search of possible sequences of NEA encounters. The effectiveness of this approach is demonstrated through a number of fully-optimized trajectories. The results show that it is possible to visit five NEAs within 10 years with near-term solar-sail technology. Moreover, a study on a reduced NEA database demonstrates the reliability of the approach used, showing that 58% of the sequences found with an approximated trajectory model can be converted into real solar-sail trajectories. Lastly, this second study shows the effectiveness of the proposed automatic optimization algorithm, which is able to find solutions for a large number of mission scenarios without any input required from the user. KW - Multiphase KW - Trajectory Optimization KW - Automated Optimization KW - Gossamer KW - Sequence-Search Y1 - 2017 N1 - Fourth International Symposium on Solar Sailing (ISSS 2017), Kyoto, Japan, 17-20 Jan 2017. http://www.jsforum.or.jp/ISSS2017/ SP - 1 EP - 11 ER - TY - CHAP A1 - Schiffer, Stefan A1 - Ferrein, Alexander T1 - A System Layout for Cognitive Service Robots T2 - Cognitive Robot Architectures. Proceedings of EUCognition 2016 Y1 - 2017 SN - 1613-0073 N1 - CEUR-WS Vol-1855 SP - 44 EP - 45 ER - TY - CHAP A1 - Zug, Sebastian A1 - Niemueller, Tim A1 - Hochgeschwender, Nico A1 - Seidensticker, Kai A1 - Seidel, Martin A1 - Friedrich, Tim A1 - Neumann, Tobias A1 - Karras, Ulrich A1 - Kraetzschmar, Gerhard K. A1 - Ferrein, Alexander T1 - An Integration Challenge to Bridge the Gap Among Industry-Inspired RoboCup Leagues T2 - RoboCup 2016: Robot World Cup XX. RoboCup 2016. Y1 - 2017 SN - 978-3-319-68792-6 U6 - https://doi.org/10.1007/978-3-319-68792-6_13 N1 - Lecture Notes in Computer Science, LNCS, Vol 9776 SP - 157 EP - 168 PB - Springer CY - Cham ER - TY - CHAP A1 - Stopforth, Riaan A1 - Davrajh, Shaniel A1 - Ferrein, Alexander T1 - South African robotics entity for a collaboration initiative T2 - Pattern Recognition Association of South Africa and Robotics and Mechatronics International Conference (PRASA-RobMech), 2016 Y1 - 2017 SN - 978-1-5090-3335-5 U6 - https://doi.org/10.1109/RoboMech.2016.7813144 N1 - PRASA-RobMech, Nov. 30 2016-Dec. 2 2016, Stellenbosch, South Africa SP - 1 EP - 6 PB - IEEE ER - TY - CHAP A1 - Tran, N. T. A1 - Tran, Thanh Ngoc A1 - Matthies, M. G. A1 - Stavroulakis, G. E. A1 - Staat, Manfred T1 - Shakedown Analysis Under Stochastic Uncertainty by Chance Constrained Programming T2 - Advances in Direct Methods for Materials and Structures N2 - In this paper we propose a stochastic programming method to analyse limit and shakedown of structures under uncertainty condition of strength. Based on the duality theory, the shakedown load multiplier formulated by the kinematic theorem is proved actually to be the dual form of the shakedown load multiplier formulated by static theorem. In this investigation a dual chance constrained programming algorithm is developed to calculate simultaneously both the upper and lower bounds of the plastic collapse limit and the shakedown limit. The edge-based smoothed finite element method (ES-FEM) with three-node linear triangular elements is used for structural analysis. Y1 - 2017 SN - 978-3-319-59810-9 U6 - https://doi.org/10.1007/978-3-319-59810-9_6 SP - 85 EP - 103 PB - Springer CY - Cham ER - TY - CHAP A1 - Dowidat, Linda A1 - König, Johannes Alexander A1 - Wolf, Martin R. T1 - The motivational competence developing game framework T2 - Mensch und Computer 2017 - Tagungsband N2 - Competence Developing Games (CDGs) are a new concept of how to think about games with serious intentions. In order to emphasize on this topic, a new framework has been developed. It basically relies on learning and motivation theories. This ‘motivational Competence Developing Game Framework’ demonstrates how it is possible to use these theories in a CDG development process. The theoretical derivation and use of the framework is explained in this paper. KW - Competence Developing Games KW - Serious Games KW - Gamification KW - motivation theories KW - learning theories Y1 - 2017 U6 - https://doi.org/10.18420/muc2017-mci-0130 SP - 15 EP - 26 PB - Gesellschaft für Informatik e.V. CY - Regensburg ER - TY - CHAP A1 - Thurn, Laura A1 - Gebhardt, Andreas T1 - Arousing Enthusiasm for STEM: Teaching 3D Printing Technology T2 - Conference Proceedings: New Perspectives in Science Education Y1 - 2017 SN - 978-88-6292-847-2 SP - 87 EP - 92 PB - liberiauniversitaria.it CY - Padua ER - TY - JOUR A1 - Hackl, Michael A1 - Wegmann, Kilian A1 - Kahmann, Stephanie Lucina A1 - Heinze, Nicolai A1 - Staat, Manfred A1 - Neiss, Wolfram F. A1 - Scaal, Martin A1 - Müller, Lars P. T1 - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow JF - Knee Surgery, Sports Traumatology, Arthroscopy Y1 - 2017 U6 - https://doi.org/10.1007/s00167-017-4468-z SN - 1433-7347 VL - 25 IS - 7 SP - 2280 EP - 2288 PB - Springer CY - Berlin ER - TY - CHAP A1 - Steuer-Dankert, Linda A1 - Sharma, Mamta Rameshwarlal A1 - Bleck, Wolfgang A1 - Leicht-Scholten, Carmen ED - Farn, C. K. T1 - Innovation through Diversity - Development of a Diversity and Innovation management concept T2 - International Conference on Innovation and Management : IAM23017S : Date: July 4-7, 2017, Osaka, Japan N2 - Acknowledging that a diverse workforce could be a potential source of innovation, the current research deals with the fine details of why diversity management is central to achieving innovation in heterogeneous research groups and how this could be effectively realized in an organization. The types of heterogeneities addressed mainly include gender, qualification, academic discipline and intercultural perspectives. The type of organization being dealt with in this work is a complex association of research institutes at a technical university in Germany (RWTH Aachen University), namely a 'Cluster of Excellence', whereby several institutes of the university work collaboratively in different sub-projects. The 'Cluster of Excellence' is a part of the 'Excellence Initiative' of the German federal and state governments German Research Foundation (DFG) and German Council of Science and Humanities, with the ultimate aim of promoting cutting-edge research. To support interdisciplinary collaboration and thus the performance of the cluster, the development of a diversity and innovation management concept is presently in the conceptual phase and will be described in the frame of this paper. The 3-S-Diversity Model, composed of the three elements: skills, structure and strategy, serves as a basis for the development of the concept. The proposed concept consists of six phases; the first two phases lay the ground work by developing an understanding of the status quo on the forms of diversity in the Cluster of Excellence, the type of organizational structure of the member institutes and the varieties of specialist work cultures of the same. The third and the fourth phases build up on this foundation by means of qualitative and quantitative studies. While the third phase deals with the sensitization of the management level to the close connection between diversity and innovation; the need to manage them thereafter and find tailor-made methods of doing so, the fourth phase shall mainly focus on the mindset of the employees in this regard. The fifth phase shall consolidate the learnings and the ideas developed in the course of the first four phases into an implementable strategy. The ultimate phase shall be the implementation of this concept in the Cluster. The first three phases have been accomplished successfully and the preliminary results are already available. Y1 - 2017 SN - 2218-6387 SP - Panel C PB - Kuang Hui Chiu CY - Osaka ER - TY - CHAP A1 - Walenta, Robert A1 - Schellekens, Twan A1 - Ferrein, Alexander A1 - Schiffer, Stefan T1 - A decentralised system approach for controlling AGVs with ROS T2 - AFRICON, Proceedings Y1 - 2017 SN - 978-1-5386-2775-4 U6 - https://doi.org/10.1109/AFRCON.2017.8095693 SN - 2153-0033 N1 - AFRICON <2017, 18-20 Sept., Cape Town, South Africa> SP - 1436 EP - 1441 PB - IEEE ER - TY - CHAP A1 - Sauerborn, Markus A1 - Liebenstund, Lena A1 - Raue, Markus A1 - Mang, Thomas A1 - Herrmann, Ulf A1 - Dueing, Andreas T1 - Analytic method for material aging and quality analyzing to forecast long time stability of plastic micro heliostat components T2 - AIP Conference Proceedings Y1 - 2017 U6 - https://doi.org/10.1063/1.4984388 VL - 1850 IS - 1 SP - 030045-1 EP - 030045-8 ER - TY - JOUR A1 - Yoshinobu, Tatsuo A1 - Miyamoto, Ko-ichiro A1 - Werner, Frederik A1 - Poghossian, Arshak A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species JF - Annual Review of Analytical Chemistry N2 - A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed. Y1 - 2017 U6 - https://doi.org/10.1146/annurev-anchem-061516-045158 SN - 1936-1327 VL - 10 SP - 225 EP - 246 PB - Annual Reviews CY - Palo Alto, Calif. ER - TY - PAT A1 - Artmann, Gerhard A1 - Linder, Peter A1 - Bayer, Robin A1 - Gossmann, Matthias T1 - Celldrum electrode arrangement for measuring mechanical stress [Patent of invention] N2 - The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance. Y1 - 2017 N1 - Patent auch unter EP3403090, CN109477828, US2019033245 und LU92948 veröffentlicht. PB - WIPO CY - Geneva ER - TY - JOUR A1 - Kerres, Karsten A1 - Siekmann, Marko T1 - Wie kommuniziere ich prognosegestützte Instandhaltungsstrategien erfolgreich in politischen Entscheidungsgremien? JF - 3 R. Fachzeitschrift für sichere und effiziente Rohleitungssysteme Y1 - 2018 SN - 2191-9798 IS - 12 SP - 47 EP - 51 PB - Vulkan-Verl. CY - Essen ER -