TY  - JOUR
A1  - Jansen, S. V.
A1  - Behbahani, Mehdi
A1  - Laumen, M.
A1  - Kaufmann, T.
A1  - Hormes, M.
A1  - Behr, M.
A1  - Schmitz-Rode, T.
A1  - Steinseifer, U.
T1  - Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation
Y1  - 2010
N1  - Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010
ER  - 
TY  - JOUR
A1  - Jan Thimo, Grundmann
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, David
T1  - Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs
JF  - Acta Astronautica
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.actaastro.2018.03.019
SN  - 0094-5765
VL  - 156
IS  - 3
SP  - 330
EP  - 362
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Jabbari, Medisa
A1  - Bhattarai, Aroj
A1  - Anding, Ralf
A1  - Staat, Manfred
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Biomechanical simulation of different prosthetic meshes for repairing uterine/vaginal vault prolapse
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - http://dx.doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 118
EP  - 119
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - CHAP
A1  - Iomdina, Elena N.
A1  - Kiseleva, Anna A.
A1  - Kotliar, Konstantin
A1  - Luzhnov, Petr V.
T1  - Quantification of Choroidal Blood Flow Using the OCT-A System Based on Voxel Scan Processing
T2  - 2020 International Conference on Biomedical Innovations and Applications (BIA)
Y1  - 2020
SN  - 978-1-7281-7073-2
U6  - http://dx.doi.org/10.1109/BIA50171.2020.9244511
SP  - 41
EP  - 44
ER  - 
TY  - BOOK
A1  - Iomdina, E. N.
A1  - Bauer, S. M.
A1  - Kotliar, Konstantin
T1  - БИОМЕХАНИКА ГЛАЗА: ТЕОРЕТИЧЕСКИЕ АСПЕКТЫ И КЛИНИЧЕСКИЕ ПРИЛОЖЕНИЯ
T2  - Eye biomechanics : theoretical aspects and clinical applications
Y1  - 2015
SN  - 978-5-903025-57-2
PB  - Real Time
CY  - Moscow
ER  - 
TY  - JOUR
A1  - Hunker, Jan L.
A1  - Gossmann, Matthias
A1  - Raman, Aravind Hariharan
A1  - Linder, Peter
T1  - Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility
JF  - Journal of Pharmacological and Toxicological Methods
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.vascn.2021.107044
SN  - 1056-8719
VL  - 111
IS  - Article number 107044
PB  - Elsevier
CY  - New York
ER  - 
TY  - CHAP
A1  - Hunker, Jan
A1  - Jung, Alexander
A1  - Goßmann, Matthias
A1  - Linder, Peter
A1  - Staat, Manfred
ED  - Staat, Manfred
ED  - Erni, Daniel
T1  - Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue
T2  - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2  - The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.
Y1  - 2019
SN  - 978-3-940402-22-6
U6  - http://dx.doi.org/10.17185/duepublico/48750
SP  - 7
EP  - 8
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Staat, Manfred
A1  - Perez-Viana, Daniel
A1  - Simmen, Hans-Peter
A1  - Neuhaus, Valentin
A1  - Pape, Hans-Christoph
A1  - Prescher, Andreas
A1  - Ciritsis, Bernhard
T1  - Biomechanical in vitro examination of a standardized low-volume tubular femoroplasty
JF  - Clinical Biomechanics
N2  - Background
Osteoporosis is associated with the risk of fractures near the hip. Age and comorbidities increase the perioperative risk. Due to the ageing population, fracture of the proximal femur also proves to be a socio-economic problem. Preventive surgical measures have hardly been used so far.

Methods
10 pairs of human femora from fresh cadavers were divided into control and low-volume femoroplasty groups and subjected to a Hayes fall-loading fracture test. The results of the respective localization and classification of the fracture site, the Singh index determined by computed tomography (CT) examination and the parameters in terms of fracture force, work to fracture and stiffness were evaluated statistically and with the finite element method. In addition, a finite element parametric study with different position angles and variants of the tubular geometry of the femoroplasty was performed.

Findings
Compared to the control group, the work to fracture could be increased by 33.2%. The fracture force increased by 19.9%. The used technique and instrumentation proved to be standardized and reproducible with an average poly(methyl methacrylate) volume of 10.5 ml. The parametric study showed the best results for the selected angle and geometry.

Interpretation
The cadaver studies demonstrated the biomechanical efficacy of the low-volume tubular femoroplasty. The numerical calculations confirmed the optimal choice of positioning as well as the inner and outer diameter of the tube in this setting. The standardized minimally invasive technique with the instruments developed for it could be used in further comparative studies to confirm the measured biomechanical results.
Y1  - 2020
U6  - http://dx.doi.org/10.1016/j.clinbiomech.2020.105104
VL  - 80
IS  - Art. 105104
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Staat, Manfred
T1  - Optical strain measurement for the modeling of surgical meshes and their porosity
JF  - Current Directions in Biomedical Engineering
N2  - The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.
Y1  - 2018
U6  - http://dx.doi.org/10.1515/cdbme-2018-0045
SN  - 2364-5504
VL  - Band 4
IS  - 1
SP  - 181
EP  - 184
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Horbach, Andreas
A1  - Duong, Minh Tuan
A1  - Staat, Manfred
T1  - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement
JF  - Journal of the mechanical behavior of biomedical materials
Y1  - 2017
U6  - http://dx.doi.org/10.1016/j.jmbbm.2017.06.012
SN  - 1751-6161
VL  - 74
SP  - 400
EP  - 410
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Herssens, Nolan
A1  - Cowburn, James
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Cazzola, Dario
A1  - Colyer, Steffi
A1  - Minetti, Alberto E.
A1  - Pavei, Gaspare
A1  - Rittweger, Jörn
A1  - Weber, Tobias
A1  - Green, David A.
ED  - Cattaneo, Luigi
T1  - Movement in low gravity environments (MoLo) programme – the MoLo-L.O.O.P. study protocol
JF  - PLOS ONE / Public Library of Science
N2  - Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity.
Y1  - 2022
U6  - http://dx.doi.org/10.1371/journal.pone.0278051
SN  - 1932-6203
VL  - 17
IS  - 11
PB  - Plos
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Heinzel, Alexander
A1  - Schäfer, Ralf
A1  - Müller, Hans-Wilhelm
A1  - Schieffer, Andre
A1  - Ingenhag, Ariane
A1  - Northoff, Georg
A1  - Franz, Matthias
A1  - Hautzel, Hubertus
T1  - Differential modulation of valence and arousal in high-alexithymic and low-alexithymic individuals
JF  - Neuroreport
N2  - High-alexithymic individuals are characterized by an impaired ability to identify and communicate emotions whereas low-alexithymic individuals have a wide-ranging ability to deal with emotions. This study examined the hypothesis that valence and arousal modifications of emotional stimuli differentially modulate cortical regions in high-alexithymic and low-alexithymic individuals. To this end, 28 high-alexithymic and 25 low-alexithymic individuals were investigated with event-related fMRI using visual emotional stimuli. We found differential neural activations in the dorsal anterior cingulate, the insula and the amygdala. We suggest that these differences may account for the impaired ability of high-alexithymic individuals to appropriately handle emotional stimuli.
Y1  - 2010
U6  - http://dx.doi.org/10.1097/WNR.0b013e32833f38e0
SN  - 1473-558X
VL  - 21
IS  - 15
SP  - 998
EP  - 1002
PB  - Lippincott Williams & Wilkins
CY  - London
ER  - 
TY  - JOUR
A1  - Heinzel, Alexander
A1  - Schäfer, Ralf
A1  - Müller, Hans-Wilhelm
A1  - Schieffer, Andre
A1  - Ingenhag, Ariane
A1  - Eickhoff, Simon B.
A1  - Northoff, Georg
A1  - Franz, Matthias
A1  - Hautzel, Hubertus
T1  - Increased Activation of the Supragenual Anterior Cingulate Cortex during Visual Emotional Processing in Male Subjects with High Degrees of Alexithymia: An Event-Related fMRI Study
JF  - Psychotherapy and Psychosomatics
N2  - Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study.
Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System.
Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala. 
Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia.
Y1  - 2010
U6  - http://dx.doi.org/10.1159/000320121
SN  - 0033-3190
VL  - 79
IS  - 6
SP  - 363
EP  - 370
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes
JF  - Isokinetics and Exercise Science
N2  - BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.
Y1  - 2018
U6  - http://dx.doi.org/10.3233/IES-184111
SN  - 1878-5913
VL  - 26
IS  - 4
SP  - 265
EP  - 274
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Increased shoulder muscle stretch reflex elicitability in supine subject posture
JF  - Isokinetics and Exercise Science
N2  - BACKGROUND: Muscle stretch reflexes are widely used to examine neural muscle function. The knowledge of reflex response in muscles crossing the shoulder is limited. OBJECTIVE: To quantify reflex modulation according to various subject postures and different procedures of muscle pre-activation steering. METHODS: Thirteen healthy male participants performed two sets of external shoulder rotation stretches in various positions and with different procedures of muscle pre-activation steering on an isokinetic dynamometer over a range of two different pre-activation levels. All stretches were applied with a dynamometer acceleration of 104∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexive response was observed in all tested muscles in all experimental conditions. The reflex elicitation rate revealed a significant muscle main effect (F (5,288) = 2.358, ρ= 0.040; η2= 0.039; f= 0.637) and a significant test condition main effect (F (1,288) = 5.884, ρ= 0.016; η2= 0.020; f= 0.143). Reflex latency revealed a significant muscle pre-activation level main effect (F (1,274) = 5.008, ρ= 0.026; η2= 0.018; f= 0.469). CONCLUSION: Muscular reflexive response was more consistent in the primary internal rotators of the shoulder. Supine posture in combination with visual feedback of muscle pre-activation level enhanced the reflex elicitation rate.
Y1  - 2020
U6  - http://dx.doi.org/10.3233/IES-192219
SN  - 1878-5913
VL  - 28
IS  - 2
SP  - 139
EP  - 146
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heinke, Lars N.
A1  - Knicker, Axel J.
A1  - Albracht, Kirsten
T1  - Test-retest reliability of the internal shoulder rotator muscles' stretch reflex in healthy men
JF  - Journal of Electromyography and Kinesiology
N2  - Until now the reproducibility of the short latency stretch reflex of the internal rotator muscles of the glenohumeral joint has not been identified. Twenty-three healthy male participants performed three sets of external shoulder rotation stretches with various pre-activation levels on two different dates of measurement to assess test-retest reliability. All stretches were applied with a dynamometer acceleration of 104°/s2 and a velocity of 150°/s. Electromyographical response was measured via surface EMG. Reflex latencies showed a pre-activation effect (ƞ2 = 0,355). ICC ranged from 0,735 to 0,909 indicating an overall “good” relative reliability. SRD 95% lay between ±7,0 to ±12,3 ms.. The reflex gain showed overall poor test-retest reproducibility. The chosen methodological approach presented a suitable test protocol for shoulder muscles stretch reflex latency evaluation. A proof-of-concept study to validate the presented methodical approach in shoulder involvement including subjects with clinically relevant conditions is recommended.
KW  - stretch reflex
KW  - shoulder
KW  - test-retest reliability
KW  - intraclass correlation coefficient
KW  - standard error of measurement
Y1  - 2021
U6  - http://dx.doi.org/10.1016/j.jelekin.2021.102611
SN  - 1050-6411
VL  - 62
IS  - Article 102611
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hein, Andreas M.
A1  - Eubanks, T. Marshall
A1  - Lingam, Manasvi
A1  - Hibberd, Adam
A1  - Fries, Dan
A1  - Schneider, Jean
A1  - Kervella, Pierre
A1  - Kennedy, Robert
A1  - Perakis, Nikolaos
A1  - Dachwald, Bernd
T1  - Interstellar now! Missions to explore nearby interstellar objects
JF  - Advances in Space Research
N2  - The recently discovered first hyperbolic objects passing through the Solar System, 1I/’Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system.
KW  - Interstellar objects
KW  - Trajectories
KW  - Missions
Y1  - 2022
U6  - http://dx.doi.org/10.1016/j.asr.2021.06.052
SN  - 0273-1177
VL  - 69
IS  - 1
SP  - 402
EP  - 414
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hein, Andreas M.
A1  - Eubanks, T. Marshall
A1  - Hibberd, Adam
A1  - Fries, Dan
A1  - Schneider, Jean
A1  - Lingam, Manasvi
A1  - Kennedy, Robert
A1  - Perakis, Nikolaos
A1  - Dachwald, Bernd
A1  - Kervella, Pierre
T1  - Interstellar Now! Missions to and sample returns from nearby interstellar objects
N2  - The recently discovered first high velocity hyperbolic objects passing through the Solar System, 1I/'Oumuamua and 2I/Borisov, have raised the question about near term missions to Interstellar Objects. In situ spacecraft exploration of these objects will allow the direct determination of both their structure and their chemical and isotopic composition, enabling an entirely new way of studying small bodies from outside our solar system. In this paper, we map various Interstellar Object classes to mission types, demonstrating that missions to a range of Interstellar Object classes are feasible, using existing or near-term technology. We describe flyby, rendezvous and sample return missions to interstellar objects, showing various ways to explore these bodies characterizing their surface, dynamics, structure and composition. Interstellar objects likely formed very far from the solar system in both time and space; their direct exploration will constrain their formation and history, situating them within the dynamical and chemical evolution of the Galaxy. These mission types also provide the opportunity to explore solar system bodies and perform measurements in the far outer solar system.
Y1  - 2020
SP  - 1
EP  - 8
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heiligers, Jeannette
A1  - Schoutetens, Frederic
A1  - Dachwald, Bernd
T1  - Photon-sail equilibria in the alpha centauri system
JF  - Journal of Guidance, Control, and Dynamics
Y1  - 2021
U6  - http://dx.doi.org/10.2514/1.G005446
SN  - 1533-3884
SN  - 0731-5090
SN  - 0162-3192
VL  - 44
IS  - 5
SP  - 1053
EP  - 1061
ER  - 
TY  - JOUR
A1  - Heieis, Jule
A1  - Böcker, Jonas
A1  - D'Angelo, Olfa
A1  - Mittag, Uwe
A1  - Albracht, Kirsten
A1  - Schönau, Eckhard
A1  - Meyer, Andreas
A1  - Voigtmann, Thomas
A1  - Rittweger, Jörn
T1  - Curvature of gastrocnemius muscle fascicles as function of muscle–tendon complex length and contraction in humans
JF  - Physiological Reports
N2  - It has been shown that muscle fascicle curvature increases with increasing contraction level and decreasing muscle–tendon complex length. The analyses were done with limited examination windows concerning contraction level, muscle–tendon complex length, and/or intramuscular position of ultrasound imaging. With this study we aimed to investigate the correlation between fascicle arching and contraction, muscle–tendon complex length and their associated architectural parameters in gastrocnemius muscles to develop hypotheses concerning the fundamental mechanism of fascicle curving. Twelve participants were tested in five different positions (90°/105°*, 90°/90°*, 135°/90°*, 170°/90°*, and 170°/75°*; *knee/ankle angle). They performed isometric contractions at four different contraction levels (5%, 25%, 50%, and 75% of maximum voluntary contraction) in each position. Panoramic ultrasound images of gastrocnemius muscles were collected at rest and during constant contraction. Aponeuroses and fascicles were tracked in all ultrasound images and the parameters fascicle curvature, muscle–tendon complex strain, contraction level, pennation angle, fascicle length, fascicle strain, intramuscular position, sex and age group were analyzed by linear mixed effect models. Mean fascicle curvature of the medial gastrocnemius increased with contraction level (+5 m−1 from 0% to 100%; p = 0.006). Muscle–tendon complex length had no significant impact on mean fascicle curvature. Mean pennation angle (2.2 m−1 per 10°; p < 0.001), inverse mean fascicle length (20 m−1 per cm−1; p = 0.003), and mean fascicle strain (−0.07 m−1 per +10%; p = 0.004) correlated with mean fascicle curvature. Evidence has also been found for intermuscular, intramuscular, and sex-specific intramuscular differences of fascicle curving. Pennation angle and the inverse fascicle length show the highest predictive capacities for fascicle curving. Due to the strong correlations between pennation angle and fascicle curvature and the intramuscular pattern of curving we suggest for future studies to examine correlations between fascicle curvature and intramuscular fluid pressure.
KW  - biomechanics
KW  - connective tissue
KW  - physiology
KW  - ultrasound
Y1  - 2023
U6  - http://dx.doi.org/10.14814/phy2.15739
SN  - 2051-817X
VL  - 11
IS  - 11
SP  - e15739, Seite 1-11
PB  - Wiley
ER  - 
TY  - JOUR
A1  - Hauser, C.
A1  - Kotliar, Konstantin
A1  - Tholen, S.
A1  - Hasenau, A.
A1  - Suttmann, Y.
A1  - Renders, L.
A1  - Heemann, U.
A1  - Baumann, M.
A1  - Schmaderer, C.
T1  - Dynamische retinale Gefäßreaktion bei Hämodialysepatienten
JF  - Nieren- und Hochdruckkrankheiten
Y1  - 2015
U6  - http://dx.doi.org/10.5414/NHX01743a
SN  - 0300-5224
VL  - 44
IS  - 11
SP  - 480
EP  - 480
PB  - Dustri-Verlag
CY  - Oberhaching
ER  - 
TY  - JOUR
A1  - Hasan, Istabrak
A1  - Keil, Ludger
A1  - Staat, Manfred
A1  - Wahl, Gerhard
A1  - Bourauel, Christoph
T1  - Determination of the frictional coefficient of the implant-antler interface : experimental approach
JF  - Biomedical Engineering / Biomedizinische Technik
N2  - The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5–0.7 and 0.3–0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.
Y1  - 2012
SN  - 1862-278X
VL  - 57
IS  - 5
SP  - 359
EP  - 363
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hanssen, H.
A1  - Nickel, T.
A1  - Drexel, V.
A1  - Hertel, G.
A1  - Emslander, I.
A1  - Sisic, Z.
A1  - Lorang, D.
A1  - Schuster, T.
A1  - Kotliar, Konstantin
A1  - Pressler, A.
A1  - Schmidt-Trucksäss, A.
A1  - Weis, M.
A1  - Halle, M.
T1  - Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity
JF  - Atherosclerosis
Y1  - 2011
SN  - 0021-9150
VL  - 216
IS  - 2
SP  - 433
EP  - 439
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Hamou, Hussam Aldin
A1  - Kotliar, Konstantin
A1  - Tan, Sonny Kian
A1  - Weiß, Christel
A1  - Blume, Christian
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
A1  - Albanna, Walid
T1  - Surgical nuances and placement of subgaleal drains for supratentorial procedures—a prospective analysis of efficacy and outcome in 150 craniotomies
JF  - Acta Neurochirurgica
N2  - Background
For supratentorial craniotomy, surgical access, and closure technique, including placement of subgaleal drains, may vary considerably. The influence of surgical nuances on postoperative complications such as cerebrospinal fluid leakage or impaired wound healing overall remains largely unclear. With this study, we are reporting our experiences and the impact of our clinical routines on outcome in a prospectively collected data set.

Method
We prospectively observed 150 consecutive patients undergoing supratentorial craniotomy and recorded technical variables (type/length of incision, size of craniotomy, technique of dural and skin closure, type of dressing, and placement of subgaleal drains). Outcome variables (subgaleal hematoma/CSF collection, periorbital edema, impairment of wound healing, infection, and need for operative revision) were recorded at time of discharge and at late follow-up.

Results
Early subgaleal fluid collection was observed in 36.7% (2.8% at the late follow-up), and impaired wound healing was recorded in 3.3% of all cases, with an overall need for operative revision of 6.7%. Neither usage of dural sealants, lack of watertight dural closure, and presence of subgaleal drains, nor type of skin closure or dressing influenced outcome. Curved incisions, larger craniotomy, and tumor size, however, were associated with an increase in early CSF or hematoma collection (p < 0.0001, p = 0.001, p < 0.01 resp.), and larger craniotomy size was associated with longer persistence of subgaleal fluid collections (p < 0.05).

Conclusions
Based on our setting, individual surgical nuances such as the type of dural closure and the use of subgaleal drains resulted in a comparable complication rate and outcome. Subgaleal fluid collections were frequently observed after supratentorial procedures, irrespective of the closing technique employed, and resolve spontaneously in the majority of cases without significant sequelae. Our results are limited due to the observational nature in our single-center study and need to be validated by supportive prospective randomized design.
Y1  - 2020
U6  - http://dx.doi.org/10.1007/s00701-019-04196-6
SN  - 0942-0940
VL  - 2020
IS  - 162
SP  - 729
EP  - 736
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - CHAP
A1  - Hallmann, Marcus
A1  - Heidecker, Ansgar
A1  - Schlotterer, Markus
A1  - Dachwald, Bernd
T1  - GTOC8: results and methods of team 15 DLR
T2  - 26th AAS/AIAA Space Flight Mechanics Meeting, Napa, CA
N2  - This paper describes the results and methods used during the 8th Global Trajectory Optimization Competition (GTOC) of the DLR team. Trajectory optimization is crucial for most of the space missions and usually can be formulated as a global optimization problem. A lot of research has been done to different type of mission problems. The most demanding ones are low thrust transfers with e.g. gravity assist sequences. In that case the optimal control problem is combined with an integer problem. In most of the GTOCs we apply a filtering of the problem based on domain knowledge.
Y1  - 2016
N1  - 26th AAS/AIAA Space Flight Mechanics Meeting, February 14-18, 2016, Napa, California, U.S.A. Napa, CA
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Kahmann, Stephanie Lucina
A1  - Heinze, Nicolai
A1  - Staat, Manfred
A1  - Neiss, Wolfram F.
A1  - Scaal, Martin
A1  - Müller, Lars P.
T1  - Radial shortening osteotomy reduces radiocapitellar contact pressures while preserving valgus stability of the elbow
JF  - Knee Surgery, Sports Traumatology, Arthroscopy
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s00167-017-4468-z
SN  - 1433-7347
VL  - 25
IS  - 7
SP  - 2280
EP  - 2288
PB  - Springer
CY  - Berlin
ER  - 
TY  - GEN
A1  - Hackl, Michael
A1  - Wegmann, Kilian
A1  - Kahmann, Stephanie Lucina
A1  - Heinze, Nicolai
A1  - Staat, Manfred
A1  - Neiss, Wolfram F.
A1  - Scaal, Martin
A1  - Müller, Lars P.
T1  - Reply to the letter to the editor: shortening osteotomy of the proximal radius
T2  - Knee Surgery, Sports Traumatology, Arthroscopy
Y1  - 2017
U6  - http://dx.doi.org/10.1007/s00167-017-4666-8
VL  - 25
IS  - 10
SP  - 3328
EP  - 3329
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Nacov, Julia
A1  - Kammerlohr, Sandra
A1  - Staat, Manfred
A1  - Buess, Eduard
A1  - Leschinger, Tim
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - Intratendinous Strain Variations of the Supraspinatus Tendon Depending on Repair Technique: A Biomechanical Analysis Regarding the Cause of Medial Cuff Failure
JF  - The American Journal of Sports Medicine
Y1  - 2021
U6  - http://dx.doi.org/10.1177/03635465211006138
SN  - 1552-3365
SN  - 0363-5465
VL  - 49
IS  - 7
SP  - 1847
EP  - 1853
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Müller, Lars-Peter
A1  - Staat, Manfred
A1  - Kahmann, Stephanie Lucina
A1  - Wegmann, Kilian
T1  - Proximal phalangeal neck fractures of the hand — a biomechanical comparison of three fixation techniques
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Plate osteosynthesis of displaced proximal phalangeal neck fractures of the hand allows early mobilization due to a stable internal fixation. Nevertheless, joint stiffness—because of soft tissue irritation—represents a common complication leading to high complication rates. Del Pinal et al. recently reported promising clinical results for a new, minimally invasive fixation technique with a cannulated headless intramedullary compression screw. Hence, the aim of this study was to compare plate fixation of proximal phalangeal neck fractures to less two less invasive techniques: Crossed k-wire fixation and intramedullary screw fixation. We hypothesized that these fixation techniques provide inferior stability when compared to plate osteosynthesis.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 148
EP  - 149
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Leschinger, T.
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
A1  - Wegmann, Kilian
T1  - Reconstruction of the interosseous membrane in the Essex Lopresti lesion — a biomechanical evaluation
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Surgical reconstruction of the interosseous membrane (IOM) could restore longitudinal forearm stability to avoid persisting disability due to capituloradial and ulnocarpal impingement in Essex Lopresti lesions. This biomechanical study aimed to assess longitudinal forearm stability of intact specimens, after sectioning of the IOM and after reconstruction with a TightRope construct using either a single or double bundle technique.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 130
EP  - 131
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Kahmann, Stephanie Lucina
A1  - Wegmann, Kilian
A1  - Ries, Christian
A1  - Staat, Manfred
A1  - Müller, Lars-Peter
T1  - Shortening osteotomy of the proximal radius — a treatment option for isolated osteoarthritis of the lateral column of the elbow joint?
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - Treatment of posttraumatic osteoarthritis of the radial column of the elbow joint remains a challenging yet common issue.
While partial joint replacement leads to high revision rates, radial head excision has shown to severely increase joint instability. Shortening osteotomy of the radius could be an option to decrease the contact pressure of the radiohumeral joint and thereby pain levels without causing valgus instability. Hence, the aim of this biomechanical study was to evaluate the effects of radial shortening on axial load distribution and valgus stability of the elbow joint.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4080-7
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 128
EP  - 129
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hackl, Michael
A1  - Buess, Eduard
A1  - Kammerlohr, Sandra
A1  - Nacov, Julia
A1  - Staat, Manfred
A1  - Leschinger, Tim
A1  - Müller, Lars P.
A1  - Wegmann, Kilian
T1  - A "comma sign"-directed subscapularis repair in anterosuperior rotator cuff tears yields biomechanical advantages in a cadaveric model
JF  - The american journal of sports medicine
N2  - Background:
Additional stabilization of the “comma sign” in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair.
Purpose:
This in vitro investigation aimed to investigate the influence of a comma sign–directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair.
Study Design:
Controlled laboratory study.
Methods:
A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups.
Results:
The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596).
Conclusion:
The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading.
Clinical Relevance:
The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome.
Y1  - 2021
U6  - http://dx.doi.org/10.1177/03635465211031506
SN  - 1552-3365
SN  - 0363-5465
VL  - 49
IS  - 12
SP  - 3212
EP  - 3217
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Hackl, M.
A1  - Andermahr, J.
A1  - Staat, Manfred
A1  - Bremer, I.
A1  - Borggrefe, J.
A1  - Prescher, A.
A1  - Müller, L. P.
A1  - Wegmann, K.
T1  - Suture button reconstruction of the central band of the interosseous membrane in Essex-Lopresti lesions: a comparative biomechanical investigation
JF  - The Journal of Hand Surgery (European Volume)
Y1  - 2017
U6  - http://dx.doi.org/10.1177/1753193416665943
SN  - 2043-6289 (Online)
SN  - 1753-1934 (Print)
VL  - 42
IS  - 4
SP  - 370
EP  - 376
PB  - Sage
CY  - London
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Meß, Jan-Gerd
A1  - Biele, Jens
A1  - Seefeldt, Patric
A1  - Dachwald, Bernd
A1  - Spietz, Peter
A1  - Grimm, Christian D.
A1  - Spröwitz, Tom
A1  - Lange, Caroline
A1  - Ulamec, Stephan
T1  - Small spacecraft in small solar system body applications
T2  - IEEE Aerospace Conference 2017, Big Sky, Montana, USA
Y1  - 2017
SN  - 978-1-5090-1613-6
U6  - http://dx.doi.org/10.1109/AERO.2017.7943626
SP  - 1
EP  - 20
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Lange, Caroline
A1  - Dachwald, Bernd
A1  - Grimm, Christian
A1  - Koch, Aaron
A1  - Ulamec, Stephan
T1  - Small Spacecraft in Planetary Defence Related Applications–Capabilities, Constraints, Challenges
T2  - IEEE Aerospace Conference
N2  - In this paper we present an overview of the characteristics and peculiarities of small spacecraft missions related to planetary defence applications. We provide a brief overview of small spacecraft missions to small solar system bodies. On this background we present recent missions and selected projects and related studies at the German Aerospace Center, DLR, that contribute to planetary defence related activities. These range from Earth orbit technology demonstrators to active science missions in interplanetary space. We provide a summary of experience from recently flown missions with DLR participation as well as a number of studies. These include PHILAE, the lander recently arrived on comet 67P/Churyumov-Gerasimenko aboard ESA’s ROSETTA comet rendezvous mission, and the Mobile Asteroid Surface Scout, MASCOT, now underway to near-Earth asteroid (162173) 1999 JU3 aboard the Japanese sample-return probe HAYABUSA-2. We introduce the differences between the conventional methods employed in the design, integration and testing of large spacecraft and the new approaches developed by small spacecraft projects. We expect that the practical experience that can be gained from projects on extremely
compressed timelines or with high-intensity operation phases on a newly explored small solar system body can contribute significantly to the study, preparation and realization of future planetary defence related missions. One is AIDA (Asteroid Impact & Deflection Assessment), a joint effort of ESA,JHU/APL, NASA, OCA and DLR, combining JHU/APL’s DART (Double Asteroid Redirection Test) and ESA’s AIM (Asteroid Impact Monitor) spacecraft in a mission towards
near-Eath binary asteroid (65803) Didymos.
KW  - small spacecraft
KW  - planetary defence
KW  - asteroid lander
KW  - solar sail
KW  - flotilla missions
Y1  - 2015
N1  - 2015 IEEE Aerospace Conference, 7.-13. Mar. 2015, Big Sky, Montana, USA.
SP  - 1
EP  - 18
ER  - 
TY  - JOUR
A1  - Grundmann, Jan Thimo
A1  - Dachwald, Bernd
A1  - Grimm, Christian D.
A1  - Kahle, Ralph
A1  - Koch, Aaron Dexter
A1  - Krause, Christian
A1  - Lange, Caroline
A1  - Quantius, Dominik
A1  - Ulamec, Stephan
T1  - Spacecraft for Hypervelocity Impact Research – An Overview of Capabilities, Constraints and the Challenges of Getting There
JF  - Procedia Engineering
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.04.021
SN  - 1877-7058
N1  - Proceedings of the 2015 Hypervelocity Impact Symposium (HVIS 2015)
VL  - Vol. 103
SP  - 151
EP  - 158
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Borella, Laura
A1  - Ceriotti, Matteo
A1  - Chand, Suditi
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Fexer, Sebastian
A1  - Grimm, Christian D.
A1  - Hendrikse, Jeffrey
A1  - Herčík, David
A1  - Herique, Alain
A1  - Hillebrandt, Martin
A1  - Ho, Tra-Mi
A1  - Kesseler, Lars
A1  - Laabs, Martin
A1  - Lange, Caroline
A1  - Lange, Michael
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin R.
A1  - Moore, Iain
A1  - Peloni, Alessandro
A1  - Plettenmeier, Dirk
A1  - Quantius, Dominik
A1  - Seefeldt, Patric
A1  - Venditti, Flaviane c. F.
A1  - Vergaaij, Merel
A1  - Viavattene, Giulia
A1  - Virkki, Anne K.
A1  - Zander, Martin
T1  - More bucks for the bang: new space solutions, impact tourism and one unique science & engineering opportunity at T-6 months and counting
T2  - 7th IAA Planetary Defense Conference
N2  - For now, the Planetary Defense Conference Exercise 2021's incoming fictitious(!), asteroid, 2021 PDC, seems headed for impact on October 20th, 2021, exactly 6 months after its discovery. Today (April 26th, 2021), the impact probability is 5%, in a steep rise from 1 in 2500 upon discovery six days ago. We all know how these things end. Or do we? Unless somebody kicked off another headline-grabbing media scare or wants to keep civil defense very idle very soon, chances are that it will hit (note: this is an exercise!). Taking stock, it is barely 6 months to impact, a steadily rising likelihood that it will actually happen, and a huge uncertainty of possible impact energies: First estimates range from 1.2 MtTNT to 13 GtTNT, and this is not even the worst-worst case: a 700 m diameter massive NiFe asteroid (covered by a thin veneer of Ryugu-black rubble to match size and brightness), would come in at 70 GtTNT. In down to Earth terms, this could be all between smashing fireworks over some remote area of the globe and a 7.5 km crater downtown somewhere. Considering the deliberate and sedate ways of development of interplanetary missions it seems we can only stand and stare until we know well enough where to tell people to pack up all that can be moved at all and save themselves. But then, it could just as well be a smaller bright rock. The best estimate is 120 m diameter from optical observation alone, by 13% standard albedo. NASA's upcoming DART mission to binary asteroid (65803) Didymos is designed to hit such a small target, its moonlet Dimorphos. The Deep Impact mission's impactor in 2005 successfully guided itself to the brightest spot on comet 9P/Tempel 1, a relatively small feature on the 6 km nucleus. And 'space' has changed: By the end of this decade, one satellite communication network plans to have launched over 11000 satellites at a pace of 60 per launch every other week. This level of series production is comparable in numbers to the most prolific commercial airliners. Launch vehicle production has not simply increased correspondingly – they can be reused, although in a trade for performance. Optical and radio astronomy as well as planetary radar have made great strides in the past decade, and so has the design and production capability for everyday 'high-tech' products. 60 years ago, spaceflight was invented from scratch within two years, and there are recent examples of fast-paced space projects as well as a drive towards 'responsive space'. It seems it is not quite yet time to abandon all hope. We present what could be done and what is too close to call once thinking is shoved out of the box by a clear and present danger, to show where a little more preparedness or routine would come in handy – or become decisive. And if we fail, let's stand and stare safely and well instrumented anywhere on Earth together in the greatest adventure of science.
Y1  - 2021
N1  - 7th IAA Planetary Defense Conference, Vienna, Austria, 26-30 April 2021
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Riemann, Johannes
A1  - Spröwitz, Tom
A1  - Tardivel, Simon
T1  - Soil to sail-asteroid landers on near-term sailcraft as an evolution of the GOSSAMER small spacecraft solar sail concept for in-situ characterization
T2  - 5th IAA Planetary Defense Conference
KW  - multiple NEA rendezvous
KW  - solar sail
KW  - GOSSAMER-1
KW  - MASCOT
KW  - asteroid sample return
Y1  - 2017
N1  - 5th IAA Planetary Defense Conference – PDC 2017
15-19 May 2017, Tokyo, Japan
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Biele, Jens
A1  - Dachwald, Bernd
A1  - Grimm, Christian
A1  - Lange, Caroline
A1  - Ulamec, Stephan
T1  - Small spacecraft for small solar system body science, planetary defence and applications
T2  - IEEE Aerospace Conference 2016
N2  - Following the recent successful landings and occasional re-awakenings of PHILAE, the lander carried aboard ROSETTA to comet 67P/Churyumov-Gerasimenko, and the launch of the Mobile Asteroid Surface Scout, MASCOT, aboard the HAYABUSA2 space probe to asteroid (162173) Ryugu we present an overview of the characteristics and peculiarities of small spacecraft missions to small solar system bodies (SSSB). Their main purpose is planetary science which is transitioning from a ‘pure’ science of observation of the distant to one also supporting in-situ applications relevant for life on Earth. Here we focus on missions at the interface of SSSB science and planetary defence applications. We provide a brief overview of small spacecraft SSSB missions and on this background present recent missions, projects and related studies at the German Aerospace Center, DLR, that contribute to the worldwide planetary defence community. These range from Earth orbit technology demonstrators to active science missions in interplanetary space. We provide a summary of experience from recently flown missions with DLR participation as well as a number of studies. These include PHILAE, the lander of ESA’s ROSETTA comet rendezvous mission now on the surface of comet 67P/Churyumov-Gerasimenko, and the Mobile Asteroid Surface Scout, MASCOT, now in cruise to the ~1 km diameter C-type near-Earth asteroid (162173) Ryugu aboard the Japanese sample-return probe HAYABUSA2. We introduce the differences between the conventional methods employed in the design, integration and testing of large spacecraft and the new approaches developed by small spacecraft projects. We expect that the practical experience that can be gained from projects on extremely compressed timelines or with high-intensity operation phases on a newly explored small solar system body can contribute significantly to the study, preparation and realization of future planetary defence related missions. One is AIDA (Asteroid Impact & Deflection Assessment), a joint effort of ESA, JHU/APL, NASA, OCA and DLR, combining JHU/APL’s DART (Double Asteroid Redirection Test) and ESA’s AIM (Asteroid Impact Monitor) spacecraft in a mission towards near-Earth binary asteroid system (65803) Didymos. DLR is currently applying MASCOT heritage and lessons learned to the design of MASCOT2, a lander for the AIM mission to support a bistatic low frequency radar experiment with PHILAE/ROSETTA CONSERT heritage to explore the inner structure of Didymoon which is the designated impact target for DART.
Y1  - 2016
SP  - 1
EP  - 20
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Biele, Jens
A1  - Dachwald, Bernd
A1  - Grimm, Christian D.
A1  - Lange, Caroline
A1  - Ulamec, Stephan
A1  - Ziach, Christian
A1  - Spröwitz, Tom
A1  - Ruffer, Michael
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Toth, Norbert
A1  - Mimasu, Yuya
A1  - Rittweger, Andreas
A1  - Bibring, Jean-Pierre
A1  - Braukhane, Andy
A1  - Boden, Ralf Christian
A1  - Dumont, Etienne
A1  - Jahnke, Stephan Siegfried
A1  - Jetzschmann, Michael
A1  - Krüger, Hans
A1  - Lange, Michael
A1  - Gomez, Antonio Martelo
A1  - Massonett, Didier
A1  - Okada, Tatsuaki
A1  - Sagliano, Marco
A1  - Sasaki, Kaname
A1  - Schröder, Silvio
A1  - Sippel, Martin
A1  - Skoczylas, Thomas
A1  - Wejmo, Elisabet
T1  - Small landers and separable sub-spacecraft for near-term solar sails
T2  - The Fourth International Symposium on Solar Sailing 2017
N2  - Following the successful PHILAE landing with ESA's ROSETTA probe and the launch of the MINERVA rovers and the Mobile Asteroid Surface Scout, MASCOT, aboard the JAXA space probe, HAYABUSA2, to asteroid (162173) Ryugu, small landers have found increasing interest. Integrated at the instrument level in their mothership they support small solar system body studies. With efficient capabilities, resource-friendly design and inherent robustness they are an attractive exploration mission element. We discuss advantages and constraints of small sub-spacecraft, focusing on emerging areas of activity such as asteroid diversity studies, planetary defence, and asteroid mining, on the background of our projects PHILAE, MASCOT, MASCOT2, the JAXA-DLR Solar Power Sail Lander Design Study, and others. The GOSSAMER-1 solar sail deployment concept also involves independent separable sub-spacecraft operating synchronized to deploy the sail. Small spacecraft require big changes in the way we do things and occasionally a little more effort than would be anticipated based on a traditional large spacecraft approach. In a Constraints-Driven Engineering environment we apply Concurrent Design and Engineering (CD/CE), Concurrent Assembly, Integration and Verification (CAIV) and Model-Based Systems Engineering (MBSE). Near-term solar sails will likely be small spacecraft which we expect to harmonize well with nano-scale separable instrument payload packages.
KW  - Small Solar System Body Lander
KW  - Small Spacecraft
KW  - PHILAE
KW  - MASCOT
KW  - Solar Power Sail
Y1  - 2017
N1  - The Fourth International Symposium on Solar Sailing 2017, 17-20 January 2017. Kyoto Research Park, Kyoto, Japan
SP  - 1
EP  - 10
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Wlademar
A1  - Borchers, Kai
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Koch, Aaron D.
A1  - Lange, Caroline
A1  - Maiwald, Volker
A1  - Meß, Jan-Gerd
A1  - Mikulz, Eugen
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Sasaki, Kaname
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Toth, Norbert
A1  - Ceriotti, Matteo
A1  - McInnes, Colin
A1  - Peloni, Alessandro
A1  - Biele, Jens
A1  - Krause, Christian
A1  - Dachwald, Bernd
A1  - Hercik, David
A1  - Lichtenheldt, Roy
A1  - Wolff, Friederike
A1  - Koncz, Alexander
A1  - Pelivan, Ivanka
A1  - Schmitz, Nicole
A1  - Boden, Ralf
A1  - Riemann, Johannes
A1  - Seboldt, Wolfgang
A1  - Wejmo, Elisabet
A1  - Ziach, Christian
A1  - Mikschl, Tobias
A1  - Montenegro, Sergio
A1  - Ruffer, Michael
A1  - Cordero, Federico
A1  - Tardivel, Simon
T1  - Solar sails for planetary defense & high-energy missions
T2  - IEEE Aerospace Conference Proceedings
N2  - 20 years after the successful ground deployment test of a (20 m) 2 solar sail at DLR Cologne, and in the light of the upcoming U.S. NEAscout mission, we provide an overview of the progress made since in our mission and hardware design studies as well as the hardware built in the course of our solar sail technology development. We outline the most likely and most efficient routes to develop solar sails for useful missions in science and applications, based on our developed `now-term' and near-term hardware as well as the many practical and managerial lessons learned from the DLR-ESTEC Gossamer Roadmap. Mission types directly applicable to planetary defense include single and Multiple NEA Rendezvous ((M)NR) for precursor, monitoring and follow-up scenarios as well as sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation. Other mission types such as the Displaced L1 (DL1) space weather advance warning and monitoring or Solar Polar Orbiter (SPO) types demonstrate the capability of near-term solar sails to achieve asteroid rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. Some of these mission types such as SPO, (M)NR and RKI include separable payloads. For one-way access to the asteroid surface, nanolanders like MASCOT are an ideal match for solar sails in micro-spacecraft format, i.e. in launch configurations compatible with ESPA and ASAP secondary payload platforms. Larger landers similar to the JAXA-DLR study of a Jupiter Trojan asteroid lander for the OKEANOS mission can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. The high impact velocities and re-try capability achieved by the RKI mission type on a final orbit identical to the target asteroid's but retrograde to its motion enables small spacecraft size impactors to carry sufficient kinetic energy for deflection.
Y1  - 2019
U6  - http://dx.doi.org/10.1109/AERO.2019.8741900
N1  - AERO 2019; Big Sky; United States; 2 March 2019 through 9 March 2019
SP  - 1
EP  - 21
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Borchers, Kai
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Lange, Caroline
A1  - Maiwald, Volker
A1  - Mikulz, Eugen
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Sasaki, Kaname
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Toth, Norbert
A1  - Wejmo, Elisabet
A1  - Biele, Jens
A1  - Krause, Christian
A1  - Cerotti, Matteo
A1  - Peloni, Alessandro
A1  - Dachwald, Bernd
T1  - Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing
T2  - 2018 IEEE Aerospace Conference : 3-10 March 2018
Y1  - 2018
SN  - 978-1-5386-2014-4
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Boden, Ralf Christian
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, D.
A1  - Herique, A.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Kofman, Wlodek
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin R.
A1  - Mikschl, Tobias
A1  - Montenegro, Sergio
A1  - Moore, Iain
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettenmeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Rogez, Yves
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Toth, Norbert
A1  - Viavattene, Giulia
A1  - Wejmo, Elisabet
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Responsive exploration and asteroid characterization through integrated solar sail and lander development using small spacecraft technologies
T2  - IAA Planetary Defense Conference
N2  - In parallel to the evolution of the Planetary Defense Conference, the exploration of small solar system bodies has advanced from fast fly-bys on the sidelines of missions to the planets to the implementation of dedicated sample-return and in-situ analysis missions. Spacecraft of all sizes have landed, touch-and-go sampled, been gently beached, or impacted at hypervelocity on asteroid and comet surfaces. More have flown by close enough to image their surfaces in detail or sample their immediate environment, often as part of an extended or re-purposed mission. And finally, full-scale planetary defense experiment missions are in the making. Highly efficient low-thrust propulsion is increasingly applied beyond commercial use also in mainstream and flagship science missions, in combination with gravity assist propulsion. Another development in the same years is the growth of small spacecraft solutions, not in size but in numbers and individual capabilities. The on-going NASA OSIRIS-REx and JAXA HAYABUSA2 missions exemplify the trend as well as the upcoming NEA SCOUT mission or the landers MINERVA-II and MASCOT recently deployed on Ryugu. We outline likely as well as possible and efficient routes of continuation of all these developments towards a propellant-less and highly efficient class of spacecraft for small solar system body exploration: small spacecraft solar sails designed for carefree handling and equipped with carried landers and application modules, for all asteroid user communities –planetary science, planetary defence, and in-situ resource utilization. This projection builds on the experience gained in the development of deployable membrane structures leading up to the successful ground deployment test of a (20 m)² solar sail at DLR Cologne and in the 20 years since. It draws on the background of extensive trajectory optimization studies, the qualified technology of the DLR GOSSAMER-1 deployment demonstrator, and the MASCOT asteroid lander. These enable ‘now-term’ as well as near-term hardware solutions, and thus responsive fast-paced development. Mission types directly applicable to planetary defense include: single and Multiple NEA Rendezvous ((M)NR) for mitigation precursor, target monitoring and deflection follow-up tasks; sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation; and deployable membrane based methods to modify the asteroid’s properties or interact with it. The DLR-ESTEC GOSSAMER Roadmap initiated studies of missions uniquely feasible with solar sails such as Displaced L1 (DL1) space weather advance warning and monitoring and Solar Polar Orbiter (SPO) delivery which demonstrate the capability of near-term solar sails to achieve NEA rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. For those mission types using separable payloads, such as SPO, (M)NR and RKI, design concepts can be derived from the separable Boom Sail Deployment Units characteristic of DLR GOSSAMER solar sail technology, nanolanders like MASCOT, or microlanders like the JAXA-DLR Jupiter Trojan Asteroid Lander for the OKEANOS mission which can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. These are an ideal match for solar sails in micro-spacecraft format whose launch configurations are compatible with ESPA and ASAP secondary payload platforms.
Y1  - 2019
N1  - Conference: IAA Planetary Defense ConferenceAt: Washington DC, USA
29.04-03.05.2019
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Boden, Ralf Christian
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, D.
A1  - Herique, A.
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Kofman, Wlodek
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin R.
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Moore, Iain
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettemeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Rogez, Yves
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Toth, Norbert
A1  - Viavattene, Giulia
A1  - Wejmo, Elisabet
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Responsive integrated small spacecraft solar sail and payload design concepts and missions
T2  - Conference: 5th International Symposium on Solar Sailing (ISSS 2019)
N2  - Asteroid mining has the potential to greatly reduce the cost of in-space manufacturing, production of propellant for space transportation and consumables for crewed spacecraft, compared to launching the required resources from Earth’s deep gravity well. This paper discusses the top-level mission architecture and trajectory design for these resource-return missions, comparing high-thrust trajectories with continuous low-thrust solar-sail trajectories. This work focuses on maximizing the economic Net Present Value, which takes the time-cost of finance into account and therefore balances the returned resource mass and mission duration. The different propulsion methods will then be compared in terms of maximum economic return, sets of attainable target asteroids, and mission flexibility. This paper provides one more step towards making commercial asteroid mining an economically viable reality by integrating trajectory design, propulsion technology and economic modelling.
Y1  - 2019
N1  - Conference: 5th International Symposium on Solar Sailing (ISSS 2019)At: Aachen, Germany
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Chand, Suditi
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Heiligers, Jeannette
A1  - Herčík, David
A1  - Hérique, Alain
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Kofman, Wlodek
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - McInnes, Colin
A1  - Meß, Jan-Gerd
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Moore, Iain
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettemeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Rogez, Yves
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Tóth, Norbert
A1  - Vergaaij, Merel
A1  - Viavattene, Giulia
A1  - Wejmo, Elisabet
A1  - Wiedemann, Carsten
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Flights are ten a sail – Re-use and commonality in the design and system engineering of small spacecraft solar sail missions with modular hardware for responsive and adaptive exploration
T2  - 70th International Astronautical Congress (IAC)
KW  - system engineering
KW  - small solar system body characterisation
KW  - small spacecraft solar sail
KW  - small spacecraft asteroid lander
KW  - responsive space
Y1  - 2019
SN  - 9781713814856
N1  - 70th International Astronautical Congress (IAC), Washington D.C., United States, 21-25 October 2019
SP  - 1
EP  - 7
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Cordero, Frederico
A1  - Dachwald, Bernd
A1  - Koncz, Alexander
A1  - Krause, Christian
A1  - Mikschl, Tobias
A1  - Montenegro, Sergio
A1  - Quantius, Dominik
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seefeldt, Patric
A1  - Tóth, Norbert
A1  - Wejmo, Elisabet
T1  - From Sail to Soil – Getting Sailcraft Out of the Harbour on a Visit to One of Earth’s Nearest Neighbours
T2  - 4th IAA Planetary Denfense Conference - PDC 2015,  13-17 April 2015, Frascati, Roma, Italy
Y1  - 2015
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian
A1  - Herčík, David
A1  - Herique, Alain
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Koch, Aaron
A1  - Kofman, Wlodek
A1  - Koncz, Alexander
A1  - Krause, Christian
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - Maiwald, Volker
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Plettemeier, Dirk
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Tardivel, Simon
A1  - Toth, Norbert
A1  - Wejmo, Elisabet
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Efficient massively parallel prospection for ISRU by multiple near-earth asteroid rendezvous using near-term solar sails and'now-term'small spacecraft solutions
T2  - 2nd Asteroid Science Intersections with In-Space Mine Engineering – ASIME 2018
N2  - Physical interaction with small solar system bodies (SSSB) is key for in-situ resource utilization (ISRU). The design of mining missions requires good understanding of SSSB properties, including composition, surface and interior structure, and thermal environment. But as the saying goes "If you've seen one asteroid, you've seen one Asteroid": Although some patterns may begin to appear, a stable and reliable scheme of SSSB classification still has to be evolved. Identified commonalities would enable generic ISRU technology and spacecraft design approaches with a high degree of re-use. Strategic approaches require much broader in-depth characterization of the SSSB populations of interest to the ISRU community. The DLR-ESTEC GOSSAMER Roadmap Science Working Groups identified target-flexible Multiple Near-Earth asteroid (NEA) Rendezvous (MNR) as one of the missions only feasible with solar sail propulsion, showed the ability to access any inclination and a wide range of heliocentric distances as well as continuous operation close to Earth's orbit where low delta-v objects reside.
Y1  - 2018
N1  - 2nd Asteroid Science Intersections with In-Space Mine Engineering – ASIME 2018
16-17 April 2018, Belval, Luxembourg
SP  - 1
EP  - 33
ER  - 
TY  - CHAP
A1  - Grundmann, Jan Thimo
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Herčík, David
A1  - Ho, Tra-Mi
A1  - Jahnke, Rico
A1  - Koch, Aaron D
A1  - Koncz, Alexander
A1  - Krause, Christian
A1  - Lange, Caroline
A1  - Lichtenheldt, Roy
A1  - Maiwald, Volker
A1  - Mikschl, Tobias
A1  - Mikulz, Eugen
A1  - Montenegro, Sergio
A1  - Pelivan, Ivanka
A1  - Peloni, Alessandro
A1  - Quantius, Dominik
A1  - Reershemius, Siebo
A1  - Renger, Thomas
A1  - Riemann, Johannes
A1  - Ruffer, Michael
A1  - Sasaki, Kaname
A1  - Schmitz, Nicole
A1  - Seboldt, Wolfgang
A1  - Seefeldt, Patric
A1  - Spietz, Peter
A1  - Spröwitz, Tom
A1  - Sznajder, Maciej
A1  - Tardivel, Simon
A1  - Tóth, Norbert
A1  - Wejmo, Elisabet
A1  - Wolff, Friederike
A1  - Ziach, Christian
T1  - Small spacecraft based multiple near-earth asteroid rendezvous and landing with near-term solar sails and ‘Now-Term ‘technologies
T2  - 69 th International Astronautical Congress (IAC)
N2  - Physical interaction with small solar system bodies (SSSB) is the next step in planetary science, planetary in-situ resource utilization (ISRU), and planetary defense (PD). It requires a broader understanding of the surface properties of the target objects, with particular interest focused on those near Earth. Knowledge of composition, multi-scale surface structure, thermal response, and interior structure is required to design, validate and operate missions addressing these three fields. The current level of understanding is occasionally simplified into the phrase, ”If you’ve seen one asteroid, you’ve seen one asteroid”, meaning that the in-situ characterization of SSSBs has yet to cross the threshold towards a robust and stable scheme of classification. This would enable generic features in spacecraft design, particularly for ISRU and science missions. Currently, it is necessary to characterize any potential target object sufficiently by a dedicated pre-cursor mission to design the mission which then interacts with the object in a complex fashion. To open up strategic approaches, much broader in-depth characterization of potential target objects would be highly desirable. In SSSB science missions, MASCOT-like nano-landers and instrument carriers which integrate at the instrument level to their mothership have met interest. By its size, MASCOT is compatible with small interplanetary missions. The DLR-ESTEC Gossamer Roadmap Science Working Groups‘ studies identified Multiple Near-Earth asteroid (NEA) Rendezvous (MNR) as one of the space science missions only feasible with solar sail propulsion. The Solar Polar Orbiter (SPO) study showed the ability to access any inclination, theDisplaced-L1 (DL1) mission operates close to Earth, where objects of interest to PD and for ISRU reside. Other studies outline the unique capability of solar sails to provide access to all SSSB, at least within the orbit of Jupiter, and significant progress has been made to explore the performance envelope of near-term solar sails for MNR. However, it is difficult for
sailcraft to interact physically with a SSSB. We expand and extend the philosophy of the recently qualified DLR Gossamer solar sail deployment technology using efficient multiple sub-spacecraft integration to also include landers for one-way in-situ investigations and sample-return missions by synergetic integration and operation of sail and lander. The MASCOT design concept and its characteristic features have created an ideal counterpart for thisand has already been adapted to the needs of the AIM spacecraft, former part of the NASA-ESA AIDA missionDesigning the 69th International Astronautical Congress (IAC), Bremen, Germany, 1-5 October 2018. IAC-18-F1.2.3 Page 2 of 17 combined spacecraft for piggy-back launch accommodation enables low-cost massively parallel access to the NEA population.
KW  - multiple NEA rendezvous
KW  - solar sail
KW  - GOSSAMER-1
KW  - MASCOT
KW  - small spacecraft
Y1  - 2018
N1  - 69th International Astronautical Congress (IAC), Bremen, Germany, 1-5 October 2018.
https://www.bho-legal.com/1-5-october-2018-69th-international-astronautical-congress-2018-in-bremen-germany/
SP  - 1
EP  - 18
ER  - 
TY  - JOUR
A1  - Grottke, O.
A1  - Braunschweig, T.
A1  - Philippen, B.
A1  - Gatzweiler, Karl-Heinz
A1  - Gronloh, N.
A1  - Staat, Manfred
A1  - Rossaint, R.
A1  - Tolba, R.
T1  - A New Model for Blunt Liver Injuries in the Swine
JF  - European Surgical Research. 44 (2010), H. 2
Y1  - 2010
SN  - 1421-9921
SP  - 65
EP  - 73
ER  - 
TY  - JOUR
A1  - Goßmann, Matthias
A1  - Frotscher, Ralf
A1  - Linder, Peter
A1  - Bayer, Robin
A1  - Epple, U.
A1  - Staat, Manfred
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells
JF  - Cellular physiology and biochemistry
N2  - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
KW  - Inotropic compounds
KW  - Pharmacology
KW  - Ion channels
KW  - CellDrum
KW  - Heart tissue culture
KW  - Induced pluripotent stem cells
KW  - Cardiac myocytes
Y1  - 2016
U6  - http://dx.doi.org/10.1159/000443124
SN  - 1421-9778 (Online)
SN  - 1015-8987 (Print)
VL  - 38
IS  - 3
SP  - 1182
EP  - 1198
PB  - Karger
CY  - Basel
ER  -