TY - CHAP A1 - Alexopoulos, Spiros A1 - Rau, Christoph A1 - Sattler, Johannes, Christoph A1 - Kronhardt, Valentina A1 - Hoffschmidt, Bernhard T1 - Simulation von Solarturmkraftwerken mit offenem volumetrischen Receiver am Standort Italien T2 - Forschung und Entwicklung für solarthermische Kraftwerke : 14. Kölner Sonnenkolloquium Mittwoch, 13. Juli 2011, im Auditorium des Campus Jülich der FH Aachen : Kurzfassungen der Vorträge und Poster Y1 - 2011 SP - 4 S. PB - DLR CY - Köln ER - TY - CHAP A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Mokrov, Oleg A1 - Zabirov, Alexander T1 - Simulation des Tropfenübergangs beim MSG-Impulslichtbogenschweißen T2 - Große Schweißtechnische Tagung 2011 : Studentenkongress 2011, Abschlusskolloquium Lichtbogenschweißen 2011; Vorträge der Veranstaltung in Hamburg Y1 - 2011 SN - 978-3-87155-267-0 SP - 554 EP - 559 PB - DVS-Media CY - Düsseldorf ER - TY - CHAP A1 - Achenbach, Timm A1 - Geimer, K. A1 - Göttsche, Joachim A1 - Hoffschmidt, Bernhard A1 - Lynen, A. A1 - Bauer, J. T1 - Simulation and flow measurements of volumetric high temperature absorbers for solar tower power plants T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - JOUR A1 - Bühler, Yves A1 - Christen, Marc A1 - Kowalski, Julia A1 - Bartelt, Perry T1 - Sensitivity of snow avalanche simulations to digital elevation model quality and resolution JF - Annals of Glaciology N2 - Digital elevation models (DEMs), represent the three-dimensional terrain and are the basic input for numerical snow avalanche dynamics simulations. DEMs can be acquired using topographic maps or remote-sensing technologies, such as photogrammetry or lidar. Depending on the acquisition technique, different spatial resolutions and qualities are achieved. However, there is a lack of studies that investigate the sensitivity of snow avalanche simulation algorithms to the quality and resolution of DEMs. Here, we perform calculations using the numerical avalance dynamics model RAMMS, varying the quality and spatial resolution of the underlying DEMs, while holding the simulation parameters constant. We study both channelized and open-terrain avalanche tracks with variable roughness. To quantify the variance of these simulations, we use well-documented large-scale avalanche events from Davos, Switzerland (winter 2007/08), and from our large-scale avalanche test site, Valĺee de la Sionne (winter 2005/06). We find that the DEM resolution and quality is critical for modeled flow paths, run-out distances, deposits, velocities and impact pressures. Although a spatial resolution of ~25 m is sufficient for large-scale avalanche modeling, the DEM datasets must be checked carefully for anomalies and artifacts before using them for dynamics calculations. KW - snow KW - avalanche Y1 - 2011 SN - 1727-5644 VL - 52 IS - 58 SP - 72 EP - 80 PB - Cambridge University Press CY - Cambridge ER - TY - CHAP A1 - Meskouris, Konstantin A1 - Holtschoppen, Britta A1 - Butenweg, Christoph A1 - Rosin, Julia T1 - Seismic analysis of liquid storage tanks T2 - Earthquake Geology and Archaeology: Science, Society and Critical facilities : proceedings ; 2nd INQUA-IGCP 567 International Workshop on Active Tectonics, Earthquake Geology, Archaeology and Engineering ; 19-24 September 2011, Corinth (Greece) / Eds.: C. Grützner ; R. Pérez-Lopez ; T. Fernández Steeger ; I. Papanikolaou ; K. Reicherter ; P. G. Silva ; A. Vött. Volume 2 Y1 - 2011 SN - 978-960-466-093-3 SP - 136 EP - 139 PB - The Natural hazards Laboratory, National and Kapodistrian University of Athens CY - Athens ER - TY - CHAP A1 - Bragard, Michael A1 - Ronge, C. A1 - De Doncker, R. W. T1 - Sandwich design of high-power thyristor based devices with integrated MOSFET structure T2 - Proceedings of the 2011 - 14th - European Conference on Power Electronics and Applications (EPE 2011) : Aug. 30, 2011 - Sept. 1, 2011, Birmingham, United Kingdom Y1 - 2011 SN - 978-1-61284-167-0 (Print) SN - 978-90-75815-15-3 (Online) PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Ferrein, Alexander A1 - Marais, Stephen A1 - Potgieter, Anet A1 - Steinbauer, Gerald T1 - RoboCup Junior: A vehicle for S&T education in Africa? Y1 - 2011 SN - 978-1-61284-992-8 N1 - AFRICON, 2011 SP - 1 EP - 6 PB - IEEE CY - New York ER - TY - JOUR A1 - Umutlu, Lale A1 - Orzada, Stephan A1 - Kinner, Sonja A1 - Maderwald, Stefan A1 - Bronte, Irina A1 - Bitz, Andreas A1 - Kraff, Oliver A1 - Ladd, Susanne C. A1 - Antoch, Gerald A1 - Ladd, Mark E. A1 - Quick, Harald H. A1 - Lauenstein, Thomas C. T1 - Renal imaging at 7 Tesla: preliminary results JF - European Radiology N2 - Objective To investigate the feasibility of 7T MR imaging of the kidneys utilising a custom-built 8-channel transmit/receive radiofrequency body coil. Methods In vivo unenhanced MR was performed in 8 healthy volunteers on a 7T whole-body MR system. After B0 shimming the following sequences were obtained: 1) 2D and 3D spoiled gradient-echo sequences (FLASH, VIBE), 2) T1-weighted 2D in and opposed phase 3) True-FISP imaging and 4) a T2-weighted turbo spin echo (TSE) sequence. Visual evaluation of the overall image quality was performed by two radiologists. Results Renal MRI at 7T was feasible in all eight subjects. Best image quality was found using T1-weighted gradient echo MRI, providing high anatomical details and excellent conspicuity of the non-enhanced vasculature. With successful shimming, B1 signal voids could be effectively reduced and/or shifted out of the region of interest in most sequence types. However, T2-weighted TSE imaging remained challenging and strongly impaired because of signal heterogeneities in three volunteers. Conclusion The results demonstrate the feasibility and diagnostic potential of dedicated 7T renal imaging. Further optimisation of imaging sequences and dedicated RF coil concepts are expected to improve the acquisition quality and ultimately provide high clinical diagnostic value. Y1 - 2011 SN - 1432-1084 VL - 21 IS - 4 SP - 841 EP - 849 PB - Springer CY - Berlin ER - TY - CHAP A1 - Fabo, Sabine ED - Schmidt, Sabine Maria T1 - REMOTEWORDS – in Erwartung des großen Beobachters T2 - Hacking the city : Interventionen in urbanen und kommunikativen Räumen ; Museum Folkwang, [16. Juli - 26. September 2010] KW - Streetart KW - Öffentlicher Raum KW - Stadtgestaltung KW - Aktionskunst KW - Kommunikationsguerrilla Y1 - 2011 SN - 978-3-86930-187-7 N1 - http://www.hackingthecity.org SP - 130 EP - 133 PB - Steidl ; Edition Folkwang CY - Göttingen [u.a.] ER - TY - CHAP A1 - Fabo, Sabine ED - Schmidt, Sabine Maria T1 - REMOTEWORDS – anticipating the big observer T2 - Hacking the city : Interventionen in urbanen und kommunikativen Räumen ; Museum Folkwang, [16. Juli - 26. September 2010] KW - Streetart KW - Öffentlicher Raum KW - Stadtgestaltung KW - Aktionskunst KW - Kommunikationsguerrilla Y1 - 2011 SN - 978-3-86930-187-7 N1 - http://www.hackingthecity.org SP - 134 EP - 137 PB - Steidl ; Edition Folkwang CY - Göttingen [u.a.] ER - TY - BOOK A1 - Blaß, Hans Joachim A1 - Uibel, Thomas T1 - Rechnerische Nachweise für das Spaltversagen von Holz in Haupt-Nebenträger-Anschlüssen. Teil 2: Überprüfung und Erweiterung des Rechenmodells Y1 - 2011 SN - 978-3-8167-8588-0 N1 - Bauforschung : T ; 3263,2 PB - Fraunhofer IRB CY - Stuttgart ER - TY - BOOK A1 - Blaß, Hans Joachim A1 - Uibel, Thomas T1 - Rechnerische Nachweise für das Spaltversagen von Holz in Haupt-Nebenträger-Anschlüssen. Teil 1: Entwicklung eines Rechenmodells Y1 - 2011 SN - 978-3-8167-8586-6 N1 - Bauforschung : T ; 3263,1 PB - Fraunhofer IRB CY - Stuttgart ER - TY - JOUR A1 - Schiffer, Stefan A1 - Ferrein, Alexander A1 - Lakemeyer, Gerhard T1 - Reasoning with Qualitative Positional Information for Domestic Domains in the Situation Calculus JF - Journal of Intelligent & Robotic Systems Y1 - 2011 SN - 0921-0296 VL - 63 IS - 2 SP - 273 EP - 300 PB - Springer CY - Berlin ER - TY - JOUR A1 - Grinsven, B. van A1 - Bon, N. vanden A1 - Grieten, L. A1 - Murib, M. A1 - Janssen, S. D. A1 - Haenen, K. A1 - Schneider, E. A1 - Ingebrandt, E. A1 - Schöning, Michael Josef A1 - Vermeeren, V. A1 - Ameloot, M. A1 - Michiels, L. A1 - Thoelen, R. A1 - Ceuninck, W. de A1 - Wagner, P. T1 - Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation JF - Lab on a Chip Y1 - 2011 SN - 1473-0197 VL - 11 IS - 9 SP - 1656 EP - 1663 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Blecken, Udo A1 - Holthaus-Sellheier, Ursula T1 - Quantitative Prognoseverfahren für den Büroimmobilienmarkt. Tl. 2 JF - GuG : Grundstücksmarkt und Grundstückswert Y1 - 2011 SN - 0938-0175 N1 - (Fortsetzung des Beitrags aus GuG 1/2011, 30) VL - 21 IS - 3 SP - 156 EP - 163 PB - Werner CY - Köln ER - TY - JOUR A1 - Blecken, Udo A1 - Holthaus-Sellheier, Ursula T1 - Quantitative Prognoseverfahren für den Büroimmobilienmarkt, Tl.1 JF - GuG : Grundstücksmarkt und Grundstückswert Y1 - 2011 SN - 0938-0175 VL - 21 IS - 1 SP - 30 EP - 39 PB - Werner CY - Köln ER - TY - JOUR A1 - Hasegawa, Maki A1 - Kapelyukh, Yury A1 - Tahara, Harunobu A1 - Seibler, Jost A1 - Rode, Anja A1 - Krueger, Sylvia A1 - Lee, Dongtao N. A1 - Wolf, C. Roland A1 - Scheer, Nico T1 - Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line JF - Molecular Pharmacology Y1 - 2011 U6 - http://dx.doi.org/10.1124/mol.111.071845 SN - 1521-0111 VL - 80 IS - 33 SP - 518 EP - 528 PB - ASPET CY - Bethesda, Md. ER - TY - JOUR A1 - Kotliar, Konstantin A1 - Baumann, Marcus A1 - Vilser, Walthard A1 - Lanzl, Ines M. T1 - Pulse wave velocity in retinal arteries of healthy volunteers JF - British Journal of Ophthalmology (eBJO) Y1 - 2011 SN - 1468-2079 VL - 95 IS - 11 SP - 675 EP - 679 PB - BMJ Publ. Group CY - London ER - TY - JOUR A1 - Niemüller, Tim A1 - Ferrein, Alexander A1 - Eckel, Gerhard A1 - Pirro, David A1 - Podbregar, Patrick A1 - Kellner, Tobias A1 - Rath, Christoph A1 - Steinbauer, Gerald T1 - Providing Ground-truth Data for the Nao Robot Platform JF - RoboCup 2010: Robot Soccer World Cup XIV Y1 - 2011 SN - 978-3-642-20217-9 N1 - Lecture Notes in Computer Science ; 6556 SP - 133 EP - 144 PB - Springer CY - Berlin ER - TY - JOUR A1 - Hacker, Tobias A1 - Kraft, Bodo A1 - Zöll, Axel T1 - Projektzuschnitt für die inkrementelle Systementwicklung im Konzernverbund Y1 - 2011 SN - 978-3-8322-9990-3 N1 - Zusammenspiel von Vorgehensmodellen und Organisationsformen, Workshop der Fachgruppe WI-VM der Gesellschaft für Informatik, 18 SP - 78 EP - 83 ER - TY - CHAP A1 - Klocke, Martina T1 - Projektmodul im Bachelorstudiengang Maschinenbau bzw. Mechatronik T2 - Hochschulrektorenkonferenz HRK nexus : Kompetenzorientiertes Prüfen in den Ingenieurwissenschaften und in der Informatik. Gemeinsame Tagung von 4ING und nexus. 29.3.2011 Bremen Y1 - 2011 SP - 1 EP - 25 ER - TY - JOUR A1 - Kern, Alexander A1 - Schelthoff, Christof A1 - Mathieu, Moritz T1 - Probability of lightning strikes to air-terminations of structures using the electro-geometrical model theory and the statistics of lightning current parameters JF - Atmospheric Research. 104 (2011) Y1 - 2011 SN - 0169-8095 N1 - Article in Press PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Knobloch, V. A1 - Kowalski, Julia A1 - Bösiger, P. A1 - Kozerke, S. T1 - Probabilistic Streamline Estimation from Accelerated Fourier Velocity Encoded Measurements T2 - Proceedings of the 19th ISMRM International Society for Magnetic Resonance in Medicine Y1 - 2011 N1 - ISMRM 19th Annual Meeting & Exhibition in Montréal, Québec, Canada SP - 1215 EP - 1215 ER - TY - JOUR A1 - Digel, Ilya T1 - Primary thermosensory events in cells JF - Transient receptor potential channels / Md. Shahidul Islam, ed. Y1 - 2011 SN - 978-94-007-0264-6 N1 - (Advances in experimental medicine and biology ; 704) SP - 451 EP - 468 PB - Springer CY - Dordrecht [u.a.] ER - TY - JOUR A1 - Oosterhuis, Koen A1 - Öhlschläger, Peter A1 - Berg, Joost H. van den A1 - Toebes, Mireille A1 - Gomez, Raquel A1 - Schumacher, Ton N. A1 - Haanen, John B. T1 - Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7 JF - International Journal of Cancer Y1 - 2011 SN - 1097-0215 VL - 129 IS - 2 SP - 397 EP - 406 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Hüning, Felix T1 - PowerMOSFETs in ANL2-Technologie : Ansteuerungen bis in den kW-Bereich mit wenig Verlustleistung und Platzbedarf JF - Elektronik-Industrie Y1 - 2011 SN - 0174-5522 VL - 42 IS - 10 SP - 36 EP - 39 PB - Hüthig CY - Heidelberg ER - TY - RPRT A1 - Artmann, Gerhard T1 - Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten. Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011 Y1 - 2011 U6 - http://dx.doi.org/10.2314/GBV:747569150 N1 - Förderkennzeichen BMBF 1736X08 PB - Technische Informationsbibliothek u. Universitätsbibliothek CY - Aachen ER - TY - JOUR A1 - Aggarwal, Prerna A1 - Singh, Virendra A1 - Singh, Arjun A1 - Scherer, Ulrich W. A1 - Singh, Tejvir A1 - Singla, Madan L. A1 - Srivastava, Alok T1 - Physico-chemical transformations in swift heavy ion modified poly(ethyleneterephthalate) JF - Radiation Physics and Chemistry Y1 - 2011 SN - 0969-806X N1 - In Press, Accepted Manuscript SP - 1 EP - 28 PB - Pergamon Press CY - Oxford ER - TY - JOUR A1 - Kallweit, Stephan A1 - Korculanin, O. A1 - Fröhlig, F. A1 - Gabi, M. A1 - Mattern, P. T1 - Photogrammetrische Rekonstruktion von Partikelpositionen mittels Rückprojektion für 3D-PIV JF - Lasermethoden in der Strömungsmesstechnik : 19. Fachtagung, 6. - 8. September 2011, Ilmenau ; [Tagungsband enthält ... Beiträge, die anlässlich der 19. Fachtagaung "Lasermethoden in der Strömungsmesstechnik" ... vorgetragen und diskutiert wurden] / veranst. von der Deutschen Gesellschaft für Laser-Anemometrie GALA e.V. Hrsg. A. Thess... Y1 - 2011 SN - 978-3-9805613-7-2 N1 - Fachtagung Lasermethoden in der Strömungsmesstechnik <19, 2011, Ilmenau> ; Deutsche Gesellschaft für Laser-Anemometrie SP - 28/1 EP - 28/6 PB - Dt. Ges. für Laser-AnemometrieGALA e. V. CY - Karlsruhe ER - TY - JOUR A1 - Döring, Bernd A1 - Feldmann, Markus A1 - Kuhnhenne, Markus A1 - Müller, Dirk T1 - Phasenwechselmaterial im Metallleichtbau zur Optimierung von Energieeffizienz und sommerlicher Raumtemperatur JF - Stahlbau Y1 - 2011 SN - 1437-1049 (E-Journal); 0038-9145 (Print) VL - Vol. 80 IS - Iss. 9 SP - 666 EP - 672 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef T1 - Phase-mode operation of FDM-LAPS JF - Sensor letters Y1 - 2011 SN - 1546-1971 VL - 9 IS - 2 SP - 691 EP - 694 PB - American Scientific Publishers CY - Stevenson Ranch, Calif. ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef T1 - Phase-mode LAPS and its application to chemical imaging JF - Sensors and Actuators B: Chemical. 154 (2011), H. 1 Y1 - 2011 SN - 1873-3077 SP - 28 EP - 32 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Scholz, Christina A1 - Romagnoli, Daniele A1 - Dachwald, Bernd A1 - Theil, Stephan T1 - Performance analysis of an attitude control system for solar sails using sliding masses JF - Advances in Space Research Y1 - 2011 SN - 0273-1177 VL - 48 IS - 11 SP - 1822 EP - 1835 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Eckey, Ulrich T1 - Paris 2011 / [Organisation: Ulrich Eckey ... Red.: Felix Bockmeyer] Y1 - 2011 PB - FH Aachen CY - Aachen ER - TY - JOUR A1 - Funke, Harald A1 - Recker, E. A1 - Bosschaerts, W. A1 - Boonen, Q. A1 - Börner, Sebastian T1 - Parametrical study of the „Micromix“ hydrogen combustion principle JF - 10th International Symposium on Experimental and Computational Aerothermodynamics of Internal Flows, ISAIF10-049, Brussels, Belgium, 4-7 July 2011 Y1 - 2011 ER - TY - CHAP A1 - Rahier, Michael A1 - Ritz, Thomas A1 - Wallenborn, Ramona T1 - Ortsbezogene Anwendungen und Dienste im eCarSharing T2 - 8. GI-ITG-KuVS-Fachgespräch Ortsbezogene Anwendungen und Dienste Y1 - 2011 SN - 978-3-8325-3041-9 SP - 61 EP - 74 PB - Logos-Verl. CY - Berlin ER - TY - JOUR A1 - Kirchner, Patrick A1 - Oberländer, Jan A1 - Friedrich, Peter A1 - Berger, Jörg A1 - Suso, Henri-Pierre A1 - Kupyna, Andriy A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Optimisation and fabrication of a calorimetric gas sensor built up on a polyimide substrate for H2O2 monitoring JF - Physica status solidi (a) : applications and material science. 208 (2011), H. 6 Y1 - 2011 SN - 1862-6319 SP - 1235 EP - 1240 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Hoffschmidt, Bernhard A1 - Telle, R. A1 - Sauerborn, Markus A1 - Wagner, M. T1 - Optical measurement system for high temperature absorbers T2 - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain Y1 - 2011 CY - Granada ER - TY - JOUR A1 - Orzada, Stephan A1 - Bitz, Andreas A1 - Schäfer, Lena C. A1 - Ladd, Susanne C. A1 - Ladd, Mark E. A1 - Maderwald, Stefan T1 - Open design eight-channel transmit/receive coil for high-resolution and real-time ankle imaging at 7 T JF - Medical Physics N2 - Purpose: At 1.5 T, real-time MRI of joint movement has been shown to be feasible. However, 7 T, provides higher SNR and thus an improved potential for parallel imaging acceleration. The purpose of this work was to build an open, U-shaped eight-channel transmit/receive microstrip coil for 7 T MRI to enable high-resolution and real-time imaging of the moving ankle joint. Methods: A U-shaped eight-channel transmit/receive array for the human ankle was built.urn:x-wiley:00942405:mp3399:equation:mp3399-math-0001-parameters and urn:x-wiley:00942405:mp3399:equation:mp3399-math-0002-factor were measured. SAR calculations of different ankle postures were performed to ensure patient safety. Inhomogeneities in the transmit field consequent to the open design were compensated for by the use of static RF shimming. High-resolution and real-time imaging was performed in human volunteers. Results: The presented array showed good performance with regard to patient comfort and image quality. High acceleration factors of up to 4 are feasible without visible acceleration artifacts. Reasonable image homogeneity was achieved with RF shimming. Conclusions: Open, noncylindrical designs for transmit/receive coils are practical at 7 T and real-time imaging of the moving joint is feasible with the presented coil design. Y1 - 2011 U6 - http://dx.doi.org/10.1118/1.3553399 SN - 2473-4209 VL - 38 IS - 3 SP - 1162 EP - 1167 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Huck, Christina A1 - Jolly, Christina A1 - Wagner, Patrick A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen JF - Procedia Engineering. 25 (2011) Y1 - 2011 SN - 1877-7058 N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece SP - 1161 EP - 1164 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grotendorst, Johannes T1 - On calculating the rate of linear convergence of non-linear transformed sequences JF - Proceeding SNC '11 Proceedings of the 2011 International Workshop on Symbolic-Numeric Computation Y1 - 2011 SN - 978-1-4503-0515-0 SP - 24 EP - 33 PB - ACM CY - New York, NY ER - TY - JOUR A1 - Jordan, Sabine D. A1 - Krüger, Markus A1 - Willmes, Diana M. A1 - Redemann, Nora A1 - Wunderlich, F. Thomas A1 - Brönneke, Hella S. A1 - Merkwirth, Carsten A1 - Kashkar, Hamid A1 - Olkkonen, Vesa M. A1 - Böttger, Thomas A1 - Braun, Thomas A1 - Seibler, Jost A1 - Brüning, Jens C. T1 - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism JF - Nature Cell Biology N2 - The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes. Y1 - 2011 U6 - http://dx.doi.org/10.1038/ncb2211 SN - 1465-7392 VL - 13 IS - 4 SP - 434 EP - 446 PB - Nature CY - New York ER - TY - CHAP A1 - Reindl, Lukas A1 - Butenweg, Christoph A1 - Kubalski, Thomas T1 - Numerical simulation of unreinforced masonry walls subject to dynamic out-of-plane loading T2 - COMPDYN 2011 : ECCOMAS Thematic Conference ; Proceedings of the 3rd International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering ; 25-28 May, 2011, Corfu, Greece / Eds.: M. Papadrakakis ... Y1 - 2011 SN - 978-960-99994-0-3 SP - 1 EP - 10 PB - National Technical Univ. of Athens CY - Athen ER - TY - JOUR A1 - Behbahani, Mehdi A1 - Tran, L. A1 - Jockenhövel, S. A1 - Behr, M. A1 - Mottaghy, K. T1 - Numerical prediction of thrombocyte reactions for application to a vascular flow model JF - British Journal of Surgery Y1 - 2011 SN - 1365-2168 N1 - 46th Congress of the European Society for Surgical Research, Aachen, Germany, 25-28 May 2011 ; ESSR Abstracts 2011 ; Oral Sessions OP10-5 VL - 98 IS - S5 SP - S17 PB - Oxford University Press CY - Oxford ER - TY - CHAP A1 - Taddei, Francesca A1 - Reindl, Lukas A1 - Park, Jin A1 - Butenweg, Christoph A1 - Karadogan, Faruk T1 - Numerical investigation of AAC wall panels based on the damage plasticity constitutive law T2 - Cement, Wapno, Beton ; 2011, 7, Special issue: 5th International Conference on Autoclaved Aerated Concrete 'Securing a sustainable future' to be held at Bydgoszcz to celebrate 60 years of AAC experience in Poland, Bydgoszcz, September 14-17, 2011 Y1 - 2011 SN - 1425-8129 SP - 86 EP - 91 PB - Stowarzyszenie Producentów Cementu i Wapna CY - Krakow ER - TY - JOUR A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Mokrov, Oleg A1 - Ahmed, Essam T1 - Numerical and experimental investigation of tensile behavior of laser beam welded TRIP700 steel JF - ISIJ international Y1 - 2011 SN - 1347-5460 (E-Journal); 0915-1559 (Print) VL - Vol. 51 IS - No. 3 SP - 429 EP - 434 PB - ISIJ CY - Tōkyō ER - TY - CHAP A1 - Reisgen, Uwe A1 - Schleser, Markus A1 - Scheik, Sven A1 - Michaeli, Walter A1 - Grönlund, Oliver A1 - Neuß, Andreas A1 - Wunderle, Johannes A1 - Poprawe, Reinhart A1 - Rösner, A. A1 - Bobzin, Kirsten A1 - Schläfer, Thomas A1 - Theiß, Sebastian A1 - Kutschmann, Pia A1 - Haberstroh, Edmund A1 - Flock, Dustin A1 - Bührig-Polaczek, Andreas A1 - Jakob, M. ED - Thoben, Klaus-Dieter T1 - Novel process chains for the production of plastics/metal-hybrids T2 - 17th International Conference on Concurrent Enterprising (ICE 2011) : Aachen, Germany, 20 - 22 June 2011 Y1 - 2011 SN - 978-1-457-70772-8 ; 978-3-943024-05-0 SP - 596 EP - 604 PB - IEEE CY - Piscataway, NJ ER - TY - JOUR A1 - Dashevsky, Alexey V. A1 - Lanzl, Ines M. A1 - Kotliar, Konstantin T1 - Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal JF - Graefe's Archive for Clinical and Experimental Ophthalmology Y1 - 2011 SN - 0721-832x VL - 249 IS - 4 SP - 565 EP - 573 PB - Springer CY - Berlin ER - TY - CHAP A1 - Bung, Daniel B. T1 - Non-intrusive measuring of air-water flow properties in self-aerated stepped spillway flow T2 - Balance and uncertainty - water in a changing world : proceedings of the 34th IAHR world congress ; 33rd Hydrology and Water Resources Symposium ; 10th Conference on Hydraulics in Water Engineering ; 26 June - 1 July 2011, Brisbane, Australia Y1 - 2011 SN - 978-0-85825-868-6 SP - 2380 EP - 2387 ER - TY - BOOK A1 - Naujokat, Anke T1 - Non est hic : Leon Battista Albertis Tempietto in der Cappella Rucellai Y1 - 2011 SN - 978-3-943164-00-8 PB - Geymüller CY - Aachen ER -