TY  - JOUR
A1  - Lehnertz, Klaus
A1  - Mormann, Florian
A1  - Osterhage, Hannes
A1  - Andy, Müller
A1  - Prusseit, Jens
A1  - Chernihovskyi, Anton
A1  - Staniek, Matthäus
A1  - Krug, Dieter
A1  - Bialonski, Stephan
A1  - Elger, Christian E.
T1  - State-of-the-art of seizure prediction
JF  - Journal of Clinical Neurophysiology
Y1  - 2007
U6  - https://doi.org/10.1097/WNP.0b013e3180336f16
SN  - 1537-1603
VL  - 24
IS  - 2
SP  - 147
EP  - 153
ER  - 
TY  - JOUR
A1  - Bhattarai, Aroj
A1  - May, Charlotte Anabell
A1  - Staat, Manfred
A1  - Kowalczyk, Wojciech
A1  - Tran, Thanh Ngoc
T1  - Layer-specific damage modeling of porcine large intestine under biaxial tension
JF  - Bioengineering
N2  - The mechanical behavior of the large intestine beyond the ultimate stress has never been investigated. Stretching beyond the ultimate stress may drastically impair the tissue microstructure, which consequently weakens its healthy state functions of absorption, temporary storage, and transportation for defecation. Due to closely similar microstructure and function with humans, biaxial tensile experiments on the porcine large intestine have been performed in this study. In this paper, we report hyperelastic characterization of the large intestine based on experiments in 102 specimens. We also report the theoretical analysis of the experimental results, including an exponential damage evolution function. The fracture energies and the threshold stresses are set as damage material parameters for the longitudinal muscular, the circumferential muscular and the submucosal collagenous layers. A biaxial tensile simulation of a linear brick element has been performed to validate the applicability of the estimated material parameters. The model successfully simulates the biomechanical response of the large intestine under physiological and non-physiological loads.
KW  - biaxial tensile experiment
KW  - anisotropy
KW  - hyperelastic
KW  - constitutive modeling
KW  - damage
Y1  - 2022
U6  - https://doi.org/10.3390/bioengineering9100528
SN  - 2306-5354
N1  - Der Artikel gehört zum Sonderheft "Computational Biomechanics"
VL  - 9
IS  - 10, Early Access
SP  - 1
EP  - 17
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Knobe, M.
A1  - Giesen, M.
A1  - Plate, S.
A1  - Gradl-Dietsch, G.
A1  - Buecking, B.
A1  - Eschbach, D.
A1  - Laack, Walter van
A1  - Pape, H.-C.
T1  - The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale
JF  - European Journal Of Trauma And Emergency Surgery
N2  - Purpose
The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale.

Methods
For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland–Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated.

Results
The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = −0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points).

Conclusion
The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status.
KW  - Tinetti test
KW  - Mobility
KW  - Mobility tests
KW  - Ground-level falls
KW  - Elderly
KW  - Fall prevention
KW  - Co-managed care
KW  - Balance
Y1  - 2016
U6  - https://doi.org/10.1007/s00068-016-0693-2
SN  - 1863-9941
VL  - 42
IS  - 5
SP  - 537
EP  - 545
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Pedraza, A. M.
A1  - Gandhi, D.
A1  - Ingebrandt, S.
A1  - Moritz, W.
A1  - Schöning, Michael Josef
T1  - An array of field-effect nanoplate SOI capacitors for (bio-)chemical sensing
JF  - Biosensors and Bioelectronics. 26 (2011), H. 6
Y1  - 2011
SN  - 0956-5663
SP  - 3023
EP  - 3028
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kurulgan Demirci, Eylem
A1  - Linder, Peter
A1  - Demirci, Taylan
A1  - Trzewik, Jürgen
A1  - Digel, Ilya
A1  - Artmann, Gerhard
A1  - Temiz Artmann, Aysegül
T1  - Contractile tension of endothelial cells: An LPS based in-vitro sepsis model
JF  - IUBMB Life. 61 (2009), H. 3
Y1  - 2009
SN  - 1521-6543
N1  - Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey
SP  - 307
EP  - 308
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Cherstvy, A.
A1  - Schöning, Michael Josef
T1  - Possibilities and limitations of label-free detection of DNA hybridization with field-effect based devices
JF  - Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].
Y1  - 2004
SN  - 88-7621-282-5
N1  - Eurosensors ; (18, 2004, Roma)
SP  - 173
EP  - 176
CY  - Roma
ER  - 
TY  - JOUR
A1  - Pham, Phu Tinh
A1  - Staat, Manfred
T1  - FEM-based shakedown analysis of hardening structures
JF  - Asia Pacific journal on computational engineering
N2  - This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature.
Y1  - 2014
U6  - https://doi.org/10.1186/2196-1166-1-4
SN  - 2196-1166 (E-Journal)
IS  - 1
SP  - Article No. 4
PB  - SpringerOpen
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Maki, Rafael M.
A1  - Paulovich, Fernando V.
A1  - Werner, Frederik
A1  - Poghossian, Arshak
A1  - Oliveira, Maria C. F. de
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor
JF  - Analytical Chemistry  (2010)
Y1  - 2010
SN  - 0003-2700
SP  - 61
EP  - 65
ER  - 
TY  - JOUR
A1  - Albanna, W.
A1  - Conzen, C.
A1  - Weiss, M.
A1  - Clusmann, H.
A1  - Fuest, M.
A1  - Mueller, M.
A1  - Brockmann, M.A.
A1  - Vilser, W.
A1  - Schmidt-Trucksäss, A.
A1  - Hoellig, A.
A1  - Seiz, M.
A1  - Thomé, C.
A1  - Kotliar, Konstantin
A1  - Schubert, G.A.
T1  - Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study
JF  - PLoS ONE
N2  - Background
Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH.

Methods
In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling.

Results
Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion.

Conclusion
RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.
Y1  - 2016
U6  - https://doi.org/10.1371/journal.pone.0158781
SN  - 1932-6203
VL  - 11
IS  - 7
PB  - PLOS
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Vornholt, Wolfgang
A1  - Werner, Frederik
A1  - Yoshinobu, Tatsuo
A1  - Miyamoto, Ko-Ichiro
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening
JF  - Physics in medicine
N2  - The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.
Y1  - 2016
U6  - https://doi.org/10.1016/j.phmed.2016.03.001
SN  - 2352-4510
VL  - 2016
IS  - 1
SP  - 2
EP  - 7
ER  - 
TY  - JOUR
A1  - Doll, Theodor
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Schöning (eds.)
JF  - Physica status solidi (a)
Y1  - 2016
U6  - https://doi.org/10.1002/pssa.201670641
SN  - 1862-6319
VL  - 213
IS  - 6
SP  - 1393
EP  - 1394
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kolditz, Melanie
A1  - Albin, Thivaharan
A1  - Abel, Dirk
A1  - Fasse, Alessandro
A1  - Brüggemann, Gert-Peter
A1  - Albracht, Kirsten
T1  - Evaluation of foot position and orientation as manipulated variables to control external knee adduction moments in leg extension training
JF  - Computer methods and programs in biomedicine
N2  - Background and Objective
Effective leg extension training at a leg press requires high forces, which need to be controlled to avoid training-induced damage. In order to avoid high external knee adduction moments, which are one reason for unphysiological loadings on knee joint structures, both training movements and the whole reaction force vector need to be observed. In this study, the applicability of lateral and medial changes in foot orientation and position as possible manipulated variables to control external knee adduction moments is investigated. As secondary parameters both the medio-lateral position of the center of pressure and the frontal-plane orientation of the reaction force vector are analyzed.

Methods
Knee adduction moments are estimated using a dynamic model of the musculoskeletal system together with the measured reaction force vector and the motion of the subject by solving the inverse kinematic and dynamic problem. Six different foot conditions with varying positions and orientations of the foot in a static leg press are evaluated and compared to a neutral foot position.

Results
Both lateral and medial wedges under the foot and medial and lateral shifts of the foot can influence external knee adduction moments in the presented study with six healthy subjects. Different effects are observed with the varying conditions: the pose of the leg is changed and the direction and center of pressure of the reaction force vector is influenced. Each effect results in a different direction or center of pressure of the reaction force vector.

Conclusions
The results allow the conclusion that foot position and orientation can be used as manipulated variables in a control loop to actively control knee adduction moments in leg extension training.
KW  - External knee adduction moments
KW  - Manipulated variables
KW  - Inverse dynamic problem
KW  - Inverse kinematic problem
KW  - Musculoskeletal model
Y1  - 2016
U6  - https://doi.org/10.1016/j.cmpb.2016.09.005
SN  - 0169-2607
N1  - Part of special issue: "SI: Personalised Models and System Identification"
VL  - 171
SP  - 81
EP  - 86
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Belavy, Daniel L.
A1  - Albracht, Kirsten
A1  - Bruggemann, Gert-Peter
A1  - Vergroesen, Pieter-Paul A.
A1  - Dieen, Jaap H. van
T1  - Can exercise positively influence the intervertebral disc?
JF  - Sports Medicine
N2  - To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a ‘critical period’ for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.
KW  - Intradiscal Pressure
KW  - Annulus Fibrosus
KW  - Disc Degeneration
KW  - Nucleus Pulposus
KW  - Intervertebral Disc
Y1  - 2016
U6  - https://doi.org/10.1007/s40279-015-0444-2
SN  - 1179-2035
VL  - 46
IS  - 4
SP  - 473
EP  - 485
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Seynnes, O. R.
A1  - Bojsen-Moller, J.
A1  - Albracht, Kirsten
A1  - Arndt, A.
A1  - Cronin, N. J.
A1  - Finni, T.
A1  - Magnusson, S. P.
T1  - Ultrasound-based testing of tendon mechanical properties: a critical evaluation
JF  - Journal of Applied Physiology
Y1  - 2015
U6  - https://doi.org/10.1152/japplphysiol.00849.2014
SN  - 8750-7587
VL  - 118
IS  - 2
SP  - 133
EP  - 141
ER  - 
TY  - JOUR
A1  - Albracht, Kirsten
A1  - Arampatzis, Adamantios
T1  - Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans
JF  - European Journal of Applied Physiology
Y1  - 2013
U6  - https://doi.org/10.1007/s00421-012-2585-4
SN  - 1439-6327
VL  - 113
IS  - 6
SP  - 1605
EP  - 1615
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Karamanidis, Kiros
A1  - Albracht, Kirsten
A1  - Braunstein, Bjoern
A1  - Catala, Maria Moreno
A1  - Goldmann, Jan-Peter
A1  - Brüggemann, Gert-Peter
T1  - Lower leg musculoskeletal geometry and sprint performance
JF  - Gait and Posture
N2  - The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.
Y1  - 2011
U6  - https://doi.org/10.1016/j.gaitpost.2011.03.009
SN  - 0966-6362
VL  - 34
IS  - 1
SP  - 138
EP  - 141
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Peper, Andreas
A1  - Bierbaum, Stefanie
A1  - Albracht, Kirsten
T1  - Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain
JF  - Journal of Biomechanics
N2  - The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47%), and the other leg at high tendon strain magnitude (4.72±1.08%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon–aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon–aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.
Y1  - 2010
U6  - https://doi.org/10.1016/j.jbiomech.2010.08.014
SN  - 0021-9290
VL  - 43
IS  - 16
SP  - 3073
EP  - 3079
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Aggeloussis, Nickos
A1  - Giannakou, Erasmia
A1  - Albracht, Kirsten
A1  - Arampatzis, Adamantios
T1  - Reproducibility of fascicle length and pennation angle of gastrocnemius medialis in human gait in vivo
JF  - Gait and Posture
N2  - The purpose of the current study was to examine the reproducibility of fascicle length and pennation angle of gastrocnemius medialis while human walking. To the best of our knowledge, this is the first study of the reproducibility of fascicle length and pennation angle of gastrocnemius medialis in vivo during human gait. Twelve males performed 10 gait trials on a treadmill, in 2 separate days. B-mode ultrasonography, with the ultrasound probe firmly adjusted in the transverse and frontal planes using a special cast, was used to measure the fascicle length and the pennation angle of the gastrocnemius medialis (GM). A Vicon 624 system with three cameras operating at 120 Hz was also used to record the ankle and knee joint angles. The results showed that measurements of fascicle length and pennation angle showed high reproducibility during the gait cycle, both within the same day and between different days. Moreover, the root mean square differences between the repeated waveforms of both variables were very small, compared with their ranges (fascicle length: RMS = ∼3 mm, range: 38–63 mm; pennation angle: RMS = ∼1.5°, range: 22–32°). However, their reproducibility was lower compared to the joint angles. It was found that representative data have to be derived by a wide number of gait trials (fascicle length ∼six trials, pennation angle more than 10 trials), to assure the reliability of the fascicle length and pennation angle in human gait.
Y1  - 2010
U6  - https://doi.org/10.1016/j.gaitpost.2009.08.249
SN  - 0966-6362
VL  - 31
IS  - 1
SP  - 73
EP  - 77
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arampatzis, Adamantios
A1  - Karamanidis, Kiros
A1  - Mademli, Lida
A1  - Albracht, Kirsten
T1  - Plasticity of the human tendon to short and long-term mechanical loading
JF  - Exercise and Sport Sciences Reviews
Y1  - 2009
U6  - https://doi.org/10.1097/JES.0b013e31819c2e1d
SN  - 1538-3008
VL  - 37
IS  - 2
SP  - 66
EP  - 72
ER  - 
TY  - JOUR
A1  - Albracht, Kirsten
A1  - Arampatzis, A.
A1  - Baltzopoulos, V.
T1  - Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo
JF  - Journal of Biomechanics
Y1  - 2008
U6  - https://doi.org/10.1016/j.jbiomech.2008.04.020
SN  - 0021-9290
VL  - 41
SP  - 2211
EP  - 2218
ER  - 
TY  - JOUR
A1  - Miyamoto, Ko-Ichiro
A1  - Sato, Takuya
A1  - Abe, Minami
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
A1  - Yoshinobu, Tatsuo
T1  - Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices
JF  - Micromachines
N2  - A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement.
KW  - light-addressable potentiometric sensor
KW  - plug-based microfluidic device
KW  - chemical sensor
Y1  - 2016
U6  - https://doi.org/10.3390/mi7070111
SN  - 2072-666X
N1  - This article belongs to the Special Issue "Micro/Nano Devices for Chemical Analysis"
VL  - 7
IS  - 7
SP  - 111
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Scheja, Sabrina
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Wagner, Torsten
T1  - Electrochemical Evaluation of Light‐Addressable Electrodes Based on TiO2 for the Integration in Lab‐on‐Chip Systems
JF  - physica status solidi a : applications and materials sciences
N2  - In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol–gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated.
Y1  - 2018
U6  - https://doi.org/10.1002/pssa.201800150
SN  - 1862-6319
VL  - 215
IS  - 15
SP  - Article number 1800150
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Oberländer, Jan
A1  - Kirchner, Patrick
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Thermocatalytic Behavior of Manganese (IV) Oxide as Nanoporous Material on the Dissociation of a Gas Mixture Containing Hydrogen Peroxide
JF  - Nanomaterials
N2  - In this article, we present an overview on the thermocatalytic reaction of hydrogen peroxide (H₂O₂) gas on a manganese (IV) oxide (MnO₂) catalytic structure. The principle of operation and manufacturing techniques are introduced for a calorimetric H₂O₂ gas sensor based on porous MnO₂. Results from surface analyses by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) of the catalytic material provide indication of the H₂O₂ dissociation reaction schemes. The correlation between theory and the experiments is documented in numerical models of the catalytic reaction. The aim of the numerical models is to provide further information on the reaction kinetics and performance enhancement of the porous MnO₂ catalyst.
Y1  - 2018
U6  - https://doi.org/10.3390/nano8040262
SN  - 2079-4991
VL  - 8
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Dikta, Gerhard
T1  - Semi-parametric random censorship models
JF  - From Statistics to Mathematical Finance : Festschrift in Honour of Winfried Stute
Y1  - 2017
SN  - 978-3-319-50986-0
U6  - https://doi.org/10.1007/978-3-319-50986-0_3
SP  - 43
EP  - 56
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pilas, Johanna
A1  - Yazici, Y.
A1  - Selmer, Thorsten
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Application of a portable multi-analyte biosensor for organic acid determination in silage
JF  - Sensors
N2  - Multi-analyte biosensors may offer the opportunity to perform cost-effective and rapid analysis with reduced sample volume, as compared to electrochemical biosensing of each analyte individually. This work describes the development of an enzyme-based biosensor system for multi-parametric determination of four different organic acids. The biosensor array comprises five working electrodes for simultaneous sensing of ethanol, formate, d-lactate, and l-lactate, and an integrated counter electrode. Storage stability of the biosensor was evaluated under different conditions (stored at +4 °C in buffer solution and dry at −21 °C, +4 °C, and room temperature) over a period of 140 days. After repeated and regular application, the individual sensing electrodes exhibited the best stability when stored at −21 °C. Furthermore, measurements in silage samples (maize and sugarcane silage) were conducted with the portable biosensor system. Comparison with a conventional photometric technique demonstrated successful employment for rapid monitoring of complex media.
Y1  - 2018
U6  - https://doi.org/10.3390/s18051470
SN  - 1424-8220
VL  - 18
IS  - 5
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Optimization of Cell-Based Multi-Chamber LAPS Measurements Utilizing FPGA-Controlled Laser-Diode Modules
JF  - physica status solidi a : applications and materials sciences
N2  - A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric device, which detects concentration changes of an analyte solution on the sensor surface in a spatially resolved way. It uses a light source to generate electron–hole pairs inside the semiconductor, which are separated in the depletion region due to an applied bias voltage across the sensor structure and hence, a surface-potential-dependent photocurrent can be read out. However, depending on the beam angle of the light source, scattering effects can occur, which influence the recorded signal in LAPS-based differential measurements. To solve this problem, a novel illumination unit based on a field programmable gate array (FPGA) consisting of 16 small-sized tunable infrared laser-diode modules (LDMs) is developed. Due to the improved focus of the LDMs with a beam angle of only 2 mrad, undesirable scattering effects are minimized. Escherichia coli (E. coli) K12 bacteria are used as a test microorganism to study the extracellular acidification on the sensor surface. Furthermore, a salt bridge chamber is built up and integrated with the LAPS system enabling multi-chamber differential measurements with a single Ag/AgCl reference electrode.
Y1  - 2018
U6  - https://doi.org/10.1002/pssa.201800058
SN  - 1862-6319
VL  - 215
IS  - 15
SP  - Article number 1800058
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Schreiber, Marc
A1  - Kraft, Bodo
A1  - Zündorf, Albert
T1  - NLP Lean Programming Framework: Developing NLP Applications More Effectively
T2  - Proceedings of NAACL-HLT 2018: Demonstrations, New Orleans, Louisiana, June 2 - 4, 2018
N2  - This paper presents NLP Lean Programming
framework (NLPf), a new framework
for creating custom natural language processing
(NLP) models and pipelines by utilizing
common software development build systems.
This approach allows developers to train and
integrate domain-specific NLP pipelines into
their applications seamlessly. Additionally,
NLPf provides an annotation tool which improves
the annotation process significantly by
providing a well-designed GUI and sophisticated
way of using input devices. Due to
NLPf’s properties developers and domain experts
are able to build domain-specific NLP
applications more efficiently. NLPf is Opensource
software and available at https://
gitlab.com/schrieveslaach/NLPf.
Y1  - 2018
U6  - https://doi.org/10.18653/v1/N18-5001 
ER  - 
TY  - JOUR
A1  - Vahidpour, Farnoosh
A1  - Oberländer, Jan
A1  - Schöning, Michael Josef
T1  - Flexible Calorimetric Gas Sensors for Detection of a Broad Concentration Range of Gaseous Hydrogen Peroxide: A Step Forward to Online Monitoring of Food-Package Sterilization Processes
JF  - Phys. Status Solidi A
N2  - In this study, flexible calorimetric gas sensors are developed for specificdetection of gaseous hydrogen peroxide (H₂O₂) over a wide concentrationrange, which is used in sterilization processes for aseptic packaging industry.The flexibility of these sensors is an advantage for identifying the chemical components of the sterilant on the corners of the food boxes, so-called “coldspots”, as critical locations in aseptic packaging, which are of great importance. These sensors are fabricated on flexible polyimide films by means of thin-film technique. Thin layers of titanium and platinum have been deposited on polyimide to define the conductive structures of the sensors. To detect the high-temperature evaporated H₂O₂, a differential temperature set-up is proposed. The sensors are evaluated in a laboratory-scaled sterilizationsystem to simulate the sterilization process. The concentration range of the evaporated H₂O₂ from 0 to 7.7% v/v was defined and the sensors have successfully detected high as well as low H₂O₂ concentrations with a sensitivity of 5.04 °C/% v/v. The characterizations of the sensors confirm their precise fabrication, high sensitivity and the novelty of low H₂O₂ concentration detections for future inline monitoring of food-package sterilization.
Y1  - 2018
U6  - https://doi.org/10.1002/pssa.201800044
VL  - 215
IS  - 15
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Schmidts, Oliver
A1  - Kraft, Bodo
A1  - Siebigteroth, Ines
A1  - Zündorf, Albert
T1  - Schema Matching with Frequent Changes on Semi-Structured Input Files: A Machine Learning Approach on Biological Product Data
T2  - Proceedings of the 21st International Conference on Enterprise Information Systems - Volume 1: ICEIS
Y1  - 2019
SN  - 978-989-758-372-8
U6  - https://doi.org/10.5220/0007723602080215
SP  - 208
EP  - 215
ER  - 
TY  - JOUR
A1  - Morais, Paulo V.
A1  - Silva, Anielle C. A.
A1  - Dantas, Noelio O.
A1  - Schöning, Michael Josef
A1  - Siqueira, José R., Jr.
T1  - Hybrid Layer‐by‐Layer Film of Polyelectrolytes‐Embedded Catalytic CoFe2O4 Nanocrystals as Sensing Units in Capacitive Electrolyte‐Insulator‐Semiconductor Devices
JF  - physica status solidi a : applications and materials sciences
Y1  - 2019
U6  - https://doi.org/10.1002/pssa.201900044
VL  - 216
IS  - 1900044
SP  - 1
EP  - 9
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lüke, Jan Niklas
A1  - Schubert, Gerrit Alexander
A1  - Dibué-Adjei, Maxine
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Steiger, Hans-Jakob
A1  - Hänggi, Daniel
A1  - Kamp, Marcel A.
A1  - Schneider, Toni
A1  - Neumaier, Felix
T1  - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity
JF  - Molecular and Cellular Neuroscience
Y1  - 2019
U6  - https://doi.org/10.1016/j.mcn.2019.03.003
SN  - 1044-7431
VL  - 96
IS  - 4
SP  - 35
EP  - 46
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Pilas, Johanna
A1  - Guthmann, Eric
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels
JF  - Sensor and Actuators B: Chemical
Y1  - 2019
U6  - https://doi.org/10.1016/j.snb.2019.02.086
SN  - 0925-4005
VL  - 288
SP  - 579
EP  - 585
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Cornelis, Peter
A1  - Givanoudi, Stella
A1  - Yongabi, Derick
A1  - Iken, Heiko
A1  - Duwé, Sam
A1  - Deschaume, Olivier
A1  - Robbens, Johan
A1  - Dedecker, Peter
A1  - Bartic, Carmen
A1  - Wübbenhorst, Michael
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Sensitive and specific detection of E. coli using biomimetic receptors in combination with a modified heat-transfer method
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.04.026
SN  - 0956-5663
VL  - 136
SP  - 97
EP  - 105
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dadfar, Dryed Mohammadali
A1  - Camozzi, Denise
A1  - Darguzyte, Milita
A1  - Roemhild, Karolin
A1  - Varvarà, Paola
A1  - Metselaar, Josbert
A1  - Banala, Srinivas
A1  - Straub, Marcel
A1  - Güver, Nihan
A1  - Engelmann, Ulrich M.
A1  - Slabu, Ioana
A1  - Buhl, Miriam
A1  - Leusen, Jan van
A1  - Kögerler, Paul
A1  - Hermanns-Sachweh, Benita
A1  - Schulz, Volkmar
A1  - Kiessling, Fabian
A1  - Lammers, Twan
T1  - Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance
JF  - Journal of Nanobiotechnology
N2  - Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.
Y1  - 2020
U6  - https://doi.org/10.1186/s12951-020-0580-1
SN  - 1477-3155
VL  - 18
IS  - Article number 22
SP  - 1
EP  - 13
PB  - Nature Portfolio
ER  - 
TY  - JOUR
A1  - Slabu, Ioana
A1  - Roeth, Anjali A.
A1  - Engelmann, Ulrich M.
A1  - Wiekhorst, Frank
A1  - Buhl, Eva M.
A1  - Neumann, Ulf P.
A1  - Schmitz-Rode, Thomas
T1  - Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro
JF  - Nanotechnology
Y1  - 2019
U6  - https://doi.org/10.1088/1361-6528/ab033e
SN  - 1361-6528
VL  - 30
IS  - 18
SP  - 184004
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Teeman, Eric
A1  - Slabu, Iona
A1  - Krishnan, Kannan M.
T1  - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - https://doi.org/10.1016/j.jmmm.2018.09.041
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 450
EP  - 456
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Seifert, Julian
A1  - Mues, Benedikt
A1  - Roitsch, Stefan
A1  - Ménager, Christine
A1  - Schmidt, Annette M.
A1  - Slabu, Ioana
T1  - Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - https://doi.org/10.1016/j.jmmm.2018.09.113
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 486
EP  - 494
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Roeth, Anjali A.J.
A1  - Eberbeck, Dietmar
A1  - Buhl, Eva Miriam
A1  - Neumann, Ulf Peter
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells
JF  - Scientific Reports
N2  - Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells.
Y1  - 2018
U6  - https://doi.org/10.1038/s41598-018-31553-9
SN  - 2045-2322
VL  - 8
IS  - 1
SP  - Article number 13210
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Buhl, Eva Miriam
A1  - Draack, Sebastian
A1  - Viereck, Thilo
A1  - Frank, 
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications
JF  - IEEE Magnetic Letters
N2  - Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23% for agglomerated MNP in suspension and a decrease by up to 28% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.
Y1  - 2018
U6  - https://doi.org/10.1109/LMAG.2018.2879034
SN  - 1949-307X
VL  - 9
IS  - Article number 8519617
PB  - IEEE
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Buhl, Eva Miriam
A1  - Baumann, Martin
A1  - Schmitz-Rode, Thomas
A1  - Slabu, Ioana
T1  - Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia
JF  - Current Directions in Biomedical Engineering
Y1  - 2017
U6  - https://doi.org/10.1515/cdbme-2017-0096
SN  - 2364-5504
VL  - 3
IS  - 2
SP  - 457
EP  - 460
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Chen, Chao
A1  - Jost, Peter
A1  - Volker, Hanno
A1  - Kaminski, Marvin
A1  - Wirtssohn, Matti R.
A1  - Engelmann, Ulrich M.
A1  - Krüger, K.
A1  - Schlich, Franziska F.
A1  - Schlockermann, Carl
A1  - Lobo, Ricardo P.S.M.
A1  - Wuttig, Matthias
T1  - Dielectric properties of amorphous phase-change materials
JF  - Physical Review B
Y1  - 2017
U6  - https://doi.org/10.1103/PhysRevB.95.094111
SN  - 2469-9950
VL  - 95
IS  - 9
SP  - Article number 094111
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Wagner, Torsten
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - A LAPS-based differential sensor for parallelized metabolism monitoring of various bacteria
JF  - Sensors
N2  - Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process.
Y1  - 2019
U6  - https://doi.org/10.3390/s19214692
SN  - 1424-8220
VL  - 19
IS  - 21
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Karschuck, T. L.
A1  - Filipov, Y.
A1  - Bollella, P.
A1  - Schöning, Michael Josef
A1  - Katz, E.
T1  - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction
JF  - International Journal of Unconventional Computing
N2  - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Y1  - 2019
SN  - 1548-7199
VL  - 14
IS  - 3-4
SP  - 235
EP  - 242
PB  - Old City Publishing
CY  - Philadelphia
ER  - 
TY  - THES
A1  - Engelmann, Ulrich M.
T1  - Assessing magnetic fluid hyperthermia : magnetic relaxation simulation, modeling of nanoparticle uptake inside pancreatic tumor cells and in vitro efficacy
Y1  - 2019
SN  - 978-3-945954-58-4
N1  - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2019
PB  - Infinite Science Publishing
CY  - Lübeck
ER  - 
TY  - JOUR
A1  - Quittmann, Oliver J.
A1  - Meskemper, Joshua
A1  - Albracht, Kirsten
A1  - Abel, Thomas
A1  - Foitschik, Tina
A1  - Strüder, Heiko K.
T1  - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs
JF  - Journal of Electromyography and Kinesiology
N2  - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA.
Y1  - 2020
U6  - https://doi.org/10.1016/j.jelekin.2020.102402
SN  - 1050-6411
VL  - 51
IS  - Article 102402
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schunck, Laura
A1  - Gosau, Martin
A1  - Smeets, Ralf
A1  - Burg, Simon
A1  - Fuest, Sandra
A1  - Kröger, Nadja
A1  - Zinser, Max
A1  - Krohn, Sebastian
A1  - Behbahani, Mehdi
A1  - Köpf, Marius
A1  - Lauts, Lisa
A1  - Rutkowski, Rico
T1  - Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes
JF  - International Journal of Molecular Sciences
N2  - In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live–dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.
Y1  - 2020
U6  - https://doi.org/10.3390/ijms21186704
SN  - 1422-0067
N1  - Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine
VL  - 21
IS  - 18 art. no. 6704
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Bozakov, Zdravko
A1  - Sander, Volker
T1  - OpenFlow: A Perspective for Building Versatile Networks
T2  - Network-Embedded Management and Applications
Y1  - 2013
SN  - 978-1-4419-6769-5
U6  - https://doi.org/10.1007/978-1-4419-6769-5_11
SP  - 217
EP  - 245
PB  - Springer
CY  - New York, NY
ER  - 
TY  - BOOK
A1  - Yoshinobu, Tatsuo
A1  - Schöning, Michael Josef
ED  - Yoshinobu, Tatsuo
ED  - Schöning, Michael Josef
T1  - Light-addressing and chemical imaging technologies for electrochemical sensing
Y1  - 2020
SN  - 978-3-03943-029-1
U6  - https://doi.org/10.3390/books978-3-03943-029-1
N1  - This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Conzen, Catharina
A1  - Albanna, Walid
A1  - Weiss, Miriam
A1  - Kürten, David
A1  - Vilser, Walthard
A1  - Kotliar, Konstantin
A1  - Zäske, Charlotte
A1  - Clusmann, Hans
A1  - Schubert, Gerrit Alexander
T1  - Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes
JF  - Translational Stroke Research
N2  - Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5–14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome.
Y1  - 2018
U6  - https://doi.org/10.1007/s12975-017-0585-8
SN  - 1868-601X
IS  - 9
SP  - 284
EP  - 293
PB  - Springer Nature
CY  - Cham
ER  - 
TY  - JOUR
A1  - Hugenroth, Kristin
A1  - Borchardt, Ralf
A1  - Ritter, Philine
A1  - Groß‑Hardt, Sascha
A1  - Meyns, Bart
A1  - Verbelen, Tom
A1  - Steinseifer, Ulrich
A1  - Kaufmann, Tim A. S.
A1  - Engelmann, Ulrich M.
T1  - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input
JF  - Scientific Reports
N2  - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.
Y1  - 2021
U6  - https://doi.org/10.1038/s41598-021-96397-2
SN  - 2045-2322
VL  - 11
IS  - Art. No. 16800
SP  - 1
EP  - 12
PB  - Springer
CY  - Berlin
ER  -