TY  - JOUR
A1  - Poghossian, Arshak
A1  - Thust, M.
A1  - Schöning, Michael Josef
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier
JF  - Sensors and Actuators B. 68 (2000), H. 1-3
Y1  - 2000
SN  - 0925-4005
SP  - 260
EP  - 265
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Brinkmann, D.
A1  - Demuth, C.
A1  - Poghossian, Arshak
T1  - CIP (cleaning-in-place)-suitable „non-glass“ pH sensor based on a Ta2O5-gate EIS structure
JF  - Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].
Y1  - 2004
SN  - 88-7621-282-5
N1  - Eurosensors ; (18, 2004, Roma)
SP  - 857
EP  - 860
CY  - Roma
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, Lars
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs
JF  - Proceedings of SPIE. 4560 (2001)
Y1  - 2001
SP  - 19
EP  - 27
ER  - 
TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer
JF  - Applied Materials Today
N2  - An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte–insulator–semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
KW  - Electrolyte–insulator–semiconductor
KW  - Capacitive field-effect
KW  - CNOT
KW  - XOR
KW  - Enzyme logic gate
Y1  - 2017
U6  - https://doi.org/10.1016/j.apmt.2017.08.003
SN  - 2352-9407
VL  - 9
SP  - 266
EP  - 270
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Beging, Stefan
A1  - Rotter, L.
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Zang, Werner
A1  - Schöning, Michael Josef
T1  - Online-Messsysteme für die automatisierte Charakterisierung von feldeffektbasierten Biosensoren
JF  - 8. Dresdner Sensor-Symposium : Sensoren für Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme für die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung für die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)
Y1  - 2007
SN  - 978-3-940046-45-1
N1  - Dresdner Sensor-Symposium <8, 2007, Dresden> ; Dresdner Beiträge zur Sensorik ; 29
SP  - 257
EP  - 260
PB  - TUDpress, Verl. der Wissenschaften
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Ecken, H.
A1  - Poghossian, Arshak
A1  - Simonis, A.
A1  - Iwasaki, H.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Constant-current-mode LAPS (CLAPS) for the detection of penicillin
JF  - Electroanalysis. 13 (2001), H. 8-9
Y1  - 2001
SN  - 1040-0397
SP  - 733
EP  - 736
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
T1  - Capacitance–voltage and impedance characteristics of field-effect EIS sensors functionalised with polyelectrolyte multilayers
JF  - IRBM. 29 (2008), H. 2-3
Y1  - 2008
SN  - 1959-0318
SP  - 149
EP  - 154
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Lüth, H.
A1  - Schultze, J. W.
A1  - Schöning, Michael Josef
T1  - (Bio-)chemical and physical microsensor array using an identical transducer principle
JF  - Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz
Y1  - 2001
SN  - 0-08-044014-2
SP  - 243
EP  - 249
PB  - Elsevier [u.a.]
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - BioFEDs (field-effect devices) : State-of-the-art and new directions
JF  - Electroanalysis
Y1  - 2006
U6  - https://doi.org/10.1002/elan.200603609
SN  - 1521-4109
VL  - 18
IS  - 19-20
SP  - 1893
EP  - 1900
ER  - 
TY  - JOUR
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Kerroumi, Iman
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Zander, Willi
A1  - Schubert, Jürgen
A1  - Buniatyan, Vahe V.
A1  - Martirosyan, Norayr W.
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Multiparameter sensor chip with Barium Strontium Titanate as multipurpose material
JF  - Electroanalysis
N2  - It is well known that biochemical and biotechnological processes are strongly dependent and affected by a variety of physico-chemical parameters such as pH value, temperature, pressure and electrolyte conductivity. Therefore, these quantities have to be monitored or controlled in order to guarantee a stable process operation, optimization and high yield. In this work, a sensor chip for the multiparameter detection of three physico-chemical parameters such as electrolyte conductivity, pH and temperature is realized using barium strontium titanate (BST) as multipurpose material. The chip integrates a capacitively coupled four-electrode electrolyte-conductivity sensor, a capacitive field-effect pH sensor and a thin-film Pt-temperature sensor. Due to the multifunctional properties of BST, it is utilized as final outermost coating layer of the processed sensor chip and serves as passivation and protection layer as well as pH-sensitive transducer material at the same time. The results of testing of the individual sensors of the developed multiparameter sensor chip are presented. In addition, a quasi-simultaneous multiparameter characterization of the sensor chip in buffer solutions with different pH value and electrolyte conductivity is performed. To study the sensor behavior and the suitability of BST as multifunctional material under harsh environmental conditions, the sensor chip was exemplarily tested in a biogas digestate.
Y1  - 2014
U6  - https://doi.org/10.1002/elan.201400076
SN  - 1521-4109 (E-Journal); 1040-0397 (Print)
VL  - 26
IS  - 5
SP  - 980
EP  - 987
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Rolka, David
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Integration of a capacitive EIS sensor into a FIA system for pH and penicillin determination
JF  - Sensors. 4 (2004)
Y1  - 2004
SN  - 1424-8220
SP  - 84
EP  - 94
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Detecting Both Physical and (Bio-)Chemical Parameters by Means of ISFET Devices
JF  - Electroanalysis. 16 (2004), H. 22
Y1  - 2004
SN  - 1040-0397
SP  - 1863
EP  - 1872
ER  - 
TY  - CHAP
A1  - Koch, Claudia
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
ED  - Wege, Christina
T1  - TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications
T2  - Virus-Derived Nanoparticles for Advanced Technologies
N2  - Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance.
KW  - Tobacco mosaic virus (TMV)
KW  - Coat protein
KW  - Enzyme nanocarrier
KW  - Glucose biosensor
KW  - Glucose oxidase
Y1  - 2018
SN  - 978-1-4939-7808-3
U6  - https://doi.org/10.1007/978-1-4939-7808-3
N1  - Methods in Molecular Biology, vol 1776
SP  - 553
EP  - 568
PB  - Humana Press
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer
JF  - Biosensors and Bioelectronics. 25 (2009), H. 2
Y1  - 2009
SN  - 0956-5663
SP  - 497
EP  - 501
ER  - 
TY  - JOUR
A1  - Gamella, Maria
A1  - Zakharchenko, Andrey
A1  - Guz, Nataliia
A1  - Masi, Madeline
A1  - Minko, Sergiy
A1  - Kolpashchikov, Dmitry M.
A1  - Iken, Heiko
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - DNA computing system activated by electrochemically triggered DNA realease from a polymer-brush-modified electrode array
JF  - Electroanalysis
N2  - An array of four independently wired indium tin oxide (ITO) electrodes was used for electrochemically stimulated DNA release and activation of DNA-based Identity, AND and XOR logic gates. Single-stranded DNA molecules were loaded on the mixed poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA)/poly(methacrylic acid) (PMAA) brush covalently attached to the ITO electrodes. The DNA deposition was performed at pH 5.0 when the polymer brush is positively charged due to protonation of tertiary amino groups in PDMAEMA, thus resulting in electrostatic attraction of the negatively charged DNA. By applying electrolysis at −1.0 V(vs. Ag/AgCl reference) electrochemical oxygen reduction resulted in the consumption of hydrogen ions and local pH increase near the electrode surface. The process resulted in recharging the polymer brush to the negative state due to dissociation of carboxylic groups of PMAA, thus repulsing the negatively charged DNA and releasing it from the electrode surface. The DNA release was performed in various combinations from different electrodes in the array assembly. The released DNA operated as input signals for activation of the Boolean logic gates. The developed system represents a step forward in DNA computing, combining for the first time DNA chemical processes with electronic input signals.
Y1  - 2017
U6  - https://doi.org/10.1002/elan.201600389
SN  - 1521-4109
VL  - 29
IS  - 2
SP  - 398
EP  - 408
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Razavi, Arash
A1  - Besmehn, Astrid
A1  - Bijnens, Nathalie
A1  - Williams, Oliver A.
A1  - Haenen, Ken
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Penicillin detection with nanocrystalline-diamond field-effect sensor
JF  - physica status solidi (a). 205 (2008), H. 9
Y1  - 2008
SN  - 1862-6319
N1  - Special Issue: Hasselt Diamond Workshop 2008 - SBDD XIII
SP  - 2141
EP  - 2145
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Ingebrandt, S.
A1  - Poghossian, Arshak
A1  - Zhang, Y.
A1  - Moritz, W.
A1  - Schöning, Michael Josef
T1  - Field-effect nanoplate capacitive pH sensor based on SOI structure
JF  - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009
Y1  - 2009
SP  - 55
EP  - 58
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - "High-order” hybrid FET module for (bio)chemical and physical sensing
JF  - Integrated analytical systems / ed. by Salvador Alegret
Y1  - 2003
SN  - 0-444-51037-0
SP  - 587
EP  - 623
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Schöning, Michael Josef
T1  - Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer
JF  - Nanoscale
N2  - A multi-spot (16 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure modified with a weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. To achieve a preferentially flat orientation of DNA strands and thus, to reduce the distance between the DNA charge and MLAPS surface, the negatively charged probe single-stranded DNAs (ssDNA) were electrostatically adsorbed onto the positively charged PAH layer using a simple layer-by-layer (LbL) technique. In this way, more DNA charge can be positioned within the Debye length, yielding a higher sensor signal. The surface potential changes in each spot induced due to the surface modification steps (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), non-specific adsorption of mismatched ssDNA) were determined from the shifts of photocurrent–voltage curves along the voltage axis. A high sensor signal of 83 mV was registered after immobilization of probe ssDNA onto the PAH layer. The hybridization signal increases from 5 mV to 32 mV with increasing the concentration of cDNA from 0.1 nM to 5 μM. In contrast, a small signal of 5 mV was recorded in the case of non-specific adsorption of fully mismatched ssDNA (5 μM). The obtained results demonstrate the potential of the MLAPS in combination with the simple and rapid LbL immobilization technique as a promising platform for the future development of multi-spot light-addressable label-free DNA chips with direct electrical readout.
Y1  - 2015
U6  - https://doi.org/10.1039/C4NR07225A
VL  - 14
IS  - 7
SP  - 6143
EP  - 6150
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Beging, Stefan
A1  - Mlynek, Daniela
A1  - Hataihimakul, Sudkanung
A1  - Poghossian, Arshak
A1  - Baldsiefen, Gerhard
A1  - Busch, Heinz
A1  - Laube, Norbert
A1  - Kleinen, Lisa
A1  - Schöning, Michael Josef
T1  - Field-effect calcium sensor for the determination of the risk of urinary stone  formation
JF  - Sensors and Actuators B: Chemical. 144 (2010), H. 2
Y1  - 2010
N1  - 22nd International Conference on Eurosensors - Dresden, Germany, 7-10 September 2008 ; Eurosensors ; (22, 2008, Dresden)
SP  - 374
EP  - 379
ER  - 
TY  - JOUR
A1  - Buniatyan, V.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Aroutiounian, V. M.
A1  - Schöning, Michael Josef
T1  - BaxSr1-x TiO3/pc-Si heterojunction
JF  - Armenian journal of physics
Y1  - 2013
SN  - 1829-1171
VL  - 6
IS  - 4
SP  - 177
EP  - 187
PB  - National Academy of Sciences of Armenia
CY  - Yerevan
ER  - 
TY  - JOUR
A1  - Yoshinobu, T.
A1  - Ecken, H.
A1  - Poghossian, Arshak
A1  - Lüth, H.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - Alternative sensor materials for light-addressable potentiometric sensors
JF  - Sensors and Actuators B. 76 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 388
EP  - 392
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Sakkari, M.
A1  - Kassab, T.
A1  - Han, Y.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Field-effect sensors for monitoring the layer-by-layer adsorption of charged macromolecules
JF  - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2
Y1  - 2006
SN  - 0925-4005
N1  - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers
SP  - 163
EP  - 170
ER  - 
TY  - JOUR
A1  - Krämer, Melina
A1  - Pita, Marcos
A1  - Zhou, Jian
A1  - Ornatska, Maryna
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information
JF  - Journal of Physical Chemistry C: Nanomaterials and Interfaces. 113 (2009), H. 6
Y1  - 2009
SN  - 1932-7455
SP  - 2573
EP  - 2579
PB  - American Cemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Werner, Frederik
A1  - Bäcker, Matthias
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips
JF  - Physica status solidi A : Applications and materials science
N2  - A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al–p-Si–SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent–voltage (I–V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I–V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge.
Y1  - 2014
U6  - https://doi.org/10.1002/pssa.201330442
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1423
EP  - 1428
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Näther, Niko
A1  - Poghossian, Arshak
A1  - Platen, J.
A1  - Yoshinobu, T.
A1  - Koudelka-Hep, M.
A1  - Schöning, Michael Josef
T1  - Multi-parameter sensing of both physical and (bio-)chemical quantities using the same transducer principle
T2  - Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...
Y1  - 2006
SP  - 172
EP  - 181
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Welden, Rene
A1  - Buniatyan, Vahe V.
A1  - Schöning, Michael Josef
T1  - An Array of On-Chip Integrated, Individually Addressable Capacitive Field-Effect Sensors with Control Gate: Design and Modelling
JF  - Sensors
N2  - The on-chip integration of multiple biochemical sensors based on field-effect electrolyte-insulator-semiconductor capacitors (EISCAP) is challenging due to technological difficulties in realization of electrically isolated EISCAPs on the same Si chip. In this work, we present a new simple design for an array of on-chip integrated, individually electrically addressable EISCAPs with an additional control gate (CG-EISCAP). The existence of the CG enables an addressable activation or deactivation of on-chip integrated individual CG-EISCAPs by simple electrical switching the CG of each sensor in various setups, and makes the new design capable for multianalyte detection without cross-talk effects between the sensors in the array. The new designed CG-EISCAP chip was modelled in so-called floating/short-circuited and floating/capacitively-coupled setups, and the corresponding electrical equivalent circuits were developed. In addition, the capacitance-voltage curves of the CG-EISCAP chip in different setups were simulated and compared with that of a single EISCAP sensor. Moreover, the sensitivity of the CG-EISCAP chip to surface potential changes induced by biochemical reactions was simulated and an impact of different parameters, such as gate voltage, insulator thickness and doping concentration in Si, on the sensitivity has been discussed.
KW  - equivalent circuit
KW  - multianalyte detection
KW  - control gate
KW  - on-chip integrated addressable EISCAP sensors
KW  - capacitive field-effect sensor
Y1  - 2021
U6  - https://doi.org/10.3390/s21186161
SN  - 1424-8220
N1  - This article belongs to the Special Issue "Field-Effect Sensors: From pH Sensing to Biosensing"
VL  - 21
IS  - 18
SP  - 17
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Katz, Evgeny
A1  - Schöning, Michael Josef
T1  - Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips
JF  - Electroanalysis
N2  - The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.
Y1  - 2017
U6  - https://doi.org/10.1002/elan.201700208
SN  - 1521-4109
VL  - 29
IS  - 8
SP  - 1840
EP  - 1849
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Wagner, P.
A1  - Haenen, K.
T1  - Feldeffektsensor auf nanokristalliner Diamantbasis
JF  - Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik
Y1  - 2008
SN  - 978-3-18-092011-5
N1  - VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008
SP  - 549
EP  - 558
PB  - VDI-Verl.
CY  - Düsseldorf
ER  - 
TY  - CHAP
A1  - Platen, Johannes
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Microstructured Nanostructures – nanostructuring by means of conventional photolithography and layer-expansion technique
N2  - A new and simple method for nanostructuring using conventional photolithography and layer expansion or pattern-size reduction technique is presented, which can further be applied for the fabrication of different nanostructures and nano-devices. The method is based on the conversion of a photolithographically patterned metal layer to a metal-oxide mask with improved pattern-size resolution using thermal oxidation. With this technique, the pattern size can be scaled down to several nanometer dimensions. The proposed method is experimentally demonstrated by preparing nanostructures with different configurations and layouts, like circles, rectangles, trapezoids, “fluidic-channel”-, “cantilever”- and meander-type structures.
KW  - Biosensor
KW  - Nanostructuring
KW  - layer expansion
KW  - pattern-size reduction
KW  - self-aligned patterning
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1477
ER  - 
TY  - JOUR
A1  - Kloock, Joachim P.
A1  - Poghossian, Arshak
A1  - Schumacher, K.
A1  - Rosenkranz, C.
A1  - Schultze, J. W.
A1  - Müller-Veggian, Mattea
A1  - Schöning, Michael Josef
T1  - Funktionsprüfung und Charakterisierung von ionensensitiven Feldeffekttransistoren (ISFETs) auf Waferebene mittels Mikrotropfenzelle für den zukünftigen Einsatz in der Sensorproduktion
JF  - Sensoren und Messsysteme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14. März 2006 in Freiburg/Breisgau / Veranst.: Informationstechnische Gesellschaft im VDE (ITG) ; VDE/VDI-Gesellschaft Mess- und Automatisierungstechnik (GMA). Wiss. Tagungsleitung: L. M. Reindl
Y1  - 2006
SN  - 3-8007-2939-3
N1  - Fachtagung Sensoren und Messsysteme <13, 2006, Freiburg, Breisgau>
SP  - 257
EP  - 260
PB  - VDE-Verl.
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
A1  - Poghossian, Arshak
A1  - Miyamoto, K.I.
A1  - Werner, C.F.
A1  - Krause, S.
A1  - Yoshinobu, T.
T1  - Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging
T2  - Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7
Y1  - 2018
SN  - 9780128097397
SP  - 295
EP  - 308
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Sensors and Actuators B. 78 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 237
EP  - 242
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Han, Y.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Poghossian, Arshak
T1  - Markierungsfreie DNA-Detektion mit Silizium-Feldeffektsensoren – Messeffekte oder Artefakte?
T2  - Sensoren und Mess-Systeme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau
Y1  - 2006
SN  - 3-8007-2939-3
SP  - 443
EP  - 446
PB  - VDE Verl.
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Chemical and biological field-effect sensors for liquids – a status report
JF  - Handbook of biosensors and biochips / ed. Robert S. Marks ... Bd. 1
Y1  - 2007
SN  - 978-0-470-01905-4
SP  - 395
EP  - 412
PB  - Wiley
CY  - Chichester
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Weil, M.
A1  - Cherstvy, A. G.
A1  - Schöning, Michael Josef
T1  - Electrical monitoring of polyelectrolyte multilayer formation by means of capacitive field-effect devices
JF  - Analytical and bioanalytical chemistry
N2  - The semiconductor field-effect platform represents a powerful tool for detecting the adsorption and binding of charged macromolecules with direct electrical readout. In this work, a capacitive electrolyte–insulator–semiconductor (EIS) field-effect sensor consisting of an Al-p-Si-SiO2 structure has been applied for real-time in situ electrical monitoring of the layer-by-layer formation of polyelectrolyte (PE) multilayers (PEM). The PEMs were deposited directly onto the SiO2 surface without any precursor layer or drying procedures. Anionic poly(sodium 4-styrene sulfonate) and cationic weak polyelectrolyte poly(allylamine hydrochloride) have been chosen as a model system. The effect of the ionic strength of the solution, polyelectrolyte concentration, number and polarity of the PE layers on the characteristics of the PEM-modified EIS sensors have been studied by means of capacitance–voltage and constant-capacitance methods. In addition, the thickness, surface morphology, roughness and wettabilityof the PE mono- and multilayers have been characterised by ellipsometry, atomic force microscopy and water contact-angle methods, respectively. To explain potential oscillations on the gate surface and signal behaviour of the capacitive field-effect EIS sensor modified with a PEM, a simplified electrostatic model that takes into account the reduced electrostatic screening of PE charges by mobile ions within the PEM has been proposed and discussed.
Y1  - 2013
U6  - https://doi.org/10.1007/s00216-013-6951-9
SN  - 1432-1130 ; 1618-2642
VL  - 405
IS  - 20
SP  - 6425
EP  - 6436
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Wu, Chunsheng
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - DNA-hybridization detection using light-addressable potentiometric sensor modified with gold layer
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 4
PB  - VDE-Verl.
CY  - Düsseldorf
ER  - 
TY  - CHAP
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Buniatyan, V.
A1  - Schöning, Michael Josef
T1  - Multi-parameter detection for supporting monitoring and control of biogas processes in agriculture
T2  - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1  - 2014
SN  - 978-3-8007-3622-5
SP  - 1
EP  - 5
PB  - VDE-Verl.
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Glück, Olaf
A1  - Thust, Marion
T1  - Electrochemical methods for the determination of chemical variables in aqueous media
T2  - Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement
Y1  - 2014
SN  - 978-1-4398-4891-3
SP  - 55-1
EP  - 55-54
PB  - CRC Pr.
CY  - Boca Raton, Fla.
ER  - 
TY  - JOUR
A1  - Knobbe, D.-T.
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Mourzina, Y.
T1  - Charakterisierung von kapazitiven EMISSensoren mittels Impedanzspektroskopie, Kapazitäts-Spannungs- und Konstant-Kapazitäts-Messung
JF  - Sensoren und Messsysteme 2004 : Tagung Ludwigsburg, 15. und 16. März 2004 / VDI-VDE-Gesellschaft Mess- und Automatisierungstechnik
Y1  - 2004
SN  - 3-18-091829-2
N1  - Auch erschienen als: VDI-Berichte ; 1829
SP  - 851
EP  - 854
PB  - VDI
CY  - Düsseldorf
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Bäcker, Matthias
A1  - Siegert, Petra
A1  - Willenberg, H.
A1  - Poghossian, Arshak
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline Based on Substrate Recycling Amplification
JF  - Procedia Engineering
N2  - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.
Y1  - 2015
U6  - https://doi.org/10.1016/j.proeng.2015.08.708
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 540
EP  - 543
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Cherstvy, Andrey G.
A1  - Pedraza, Angela M.
A1  - Ingebrandt, Sven
A1  - Schöning, Michael Josef
T1  - Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling
JF  - Physica Status Solidi (a)
N2  - Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100710
SN  - 1862-6319
VL  - 209
SP  - 925
EP  - 934
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Wagner, H.
A1  - Schöning, Michael Josef
T1  - Automatisiertes „wafer level“-Testsystem zur Charakterisierung von siliziumbasierten Chemo- und Biosensoren
JF  - Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA)
Y1  - 2010
SN  - 978-3-8007-3260-9
N1  - Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik
SP  - 89
EP  - 92
PB  - VDE Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Geissler, Hanno
A1  - Schöning, Michael Josef
T1  - Rapid methods and sensors for milk quality monitoring and spoilage detection
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - https://doi.org/10.1016/j.bios.2019.04.040
SN  - 0956-5663
VL  - 140
IS  - Article 111272
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Wagner, Holger
A1  - Schöning, Michael Josef
T1  - Functional testing and characterisation of (bio-)chemical sensors on wafer level
JF  - Procedia Chemistry. 1 (2009), H. 1
Y1  - 2009
SN  - 1876-6196
N1  - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23
SP  - 835
EP  - 838
ER  - 
TY  - JOUR
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Siqueira, José R. Jr.
A1  - Oliveira, Osvaldo N. Jr.
A1  - Moritz, Werner
A1  - Schöning, Michael Josef
T1  - Capacitive electrolyte-insulator-semiconductor structures functionalised with a polyelectrolyte/enzyme multilayer: New strategy for enhanced field-effect biosensing
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 884
EP  - 890
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Field-effect devices for detecting cellular signals
JF  - Seminars in Cell & Developmental Biology. 20 (2009), H. 1
Y1  - 2009
SN  - 1096-3634
SP  - 41
EP  - 48
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices
JF  - Physica status solidi (a). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 781
EP  - 786
ER  - 
TY  - CHAP
A1  - Buniatyan, V. V.
A1  - Huck, Christina
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Rustamyan, L. G.
A1  - Hovnikyan, H. H.
T1  - Equivalent circuit and optimization of impedance characteristics of an electrolyte conductivity sensor
T2  - Proceedings of State Engineering University Armenia : Series Information technologies, electronics, radio engineering
Y1  - 2014
VL  - Iss. 17
IS  - No. 1
SP  - 69
EP  - 76
ER  - 
TY  - JOUR
A1  - Näther, Niko
A1  - Rolka, David
A1  - Poghossian, Arshak
A1  - Koudelka-Hep, M.
A1  - Schöning, Michael Josef
T1  - Two microcell flow-injection analysis (FIA) platforms for capacitive silicon-based field-effect sensors
JF  - Electrochimica Acta. 51 (2005), H. 5
Y1  - 2005
SN  - 0013-4686
U6  - https://doi.org/10.1016/j.electacta.2005.04.066
SP  - 924
EP  - 929
ER  -