TY - CHAP A1 - Schusser, Sebastian A1 - Leinhos, Marcel A1 - Poghossian, Arshak A1 - Wagner, Patrick A1 - Schöning, Michael Josef ED - Abdelghani, Adnane ED - Schöning, Michael Josef T1 - Biopolymer-degradation monitoring by chip-­based impedance spectroscopy technique T2 - Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012 Y1 - 2012 SP - 47 EP - 47 ER - TY - BOOK A1 - Digel, Ilya A1 - Zhubanova, Azhar Ahmetovna A1 - Akimbekov, Nuraly S. T1 - Visual Virology Y1 - 2012 SN - 978-601-247-298-1 N1 - Text kasachisch, russisch, englisch CY - Almaty ER - TY - CHAP A1 - Frotscher, Ralf A1 - Raatschen, Hans-Jürgen A1 - Staat, Manfred ED - Eberhardsteiner, J. T1 - Application of an edge-based smoothed finite element method on geometrically non-linear plates of non-linear material T2 - Proceedings European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Y1 - 2012 N1 - 6th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012) Vienna, Austria, September 10-14, 2012 ER - TY - CHAP A1 - Alexopoulos, Spiros A1 - Hoffschmidt, Bernhard A1 - Rau, Christoph A1 - Sattler, Johannes Christoph T1 - Simulation of hybrid solar tower power plants T2 - 30th ISES Biennial Solar World Congress 2011 : Kassel, Germany, 28 August - 2 September 2011. Vol. 5 Y1 - 2012 SP - 4044 EP - 4050 PB - Curran CY - Red Hook, NY ER - TY - JOUR A1 - Staat, Manfred A1 - Vu, Duc Khoi T1 - Limit analysis of flaws in pressurized pipes and cylindrical vessels Part II: Circumferential defects JF - Engineering Fracture Mechanics ; 97(2013), H. 1 N2 - Upper and lower bound theorems of limit analyses have been presented in part I of the paper. Part II starts with the finite element discretization of these theorems and demonstrates how both can be combined in a primal–dual optimization problem. This recently proposed numerical method is used to guide the development of a new class of closed-form limit loads for circumferential defects, which show that only large defects contribute to plastic collapse with a rapid loss of strength with increasing crack sizes. The formulae are compared with primal–dual FEM limit analyses and with burst tests. Even closer predictions are obtained with iterative limit load solutions for the von Mises yield function and for the Tresca yield function. Pressure loading of the faces of interior cracks in thick pipes reduces the collapse load of circumferential defects more than for axial flaws. Axial defects have been treated in part I of the paper. Y1 - 2012 U6 - https://doi.org/10.1016/j.engfracmech.2012.05.017 SN - 0013-7944 VL - 97 SP - 314 EP - 333 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grande, Marion A1 - Meffert, Elisabeth A1 - Schoenberger, Eva A1 - Jung, Stefanie A1 - Frauenrath, Tobias A1 - Huber, Walter A1 - Hussmann, Katja A1 - Moormann, Mareike A1 - Heim, Stefan T1 - From a concept to a word in a syntactically complete sentence: An fMRI study on spontaneous language production in an overt picture description task JF - NeuroImage N2 - Spontaneous language has rarely been subjected to neuroimaging studies. This study therefore introduces a newly developed method for the analysis of linguistic phenomena observed in continuous language production during fMRI. Most neuroimaging studies investigating language have so far focussed on single word or — to a smaller extent — sentence processing, mostly due to methodological considerations. Natural language production, however, is far more than the mere combination of words to larger units. Therefore, the present study aimed at relating brain activation to linguistic phenomena like word-finding difficulties or syntactic completeness in a continuous language fMRI paradigm. A picture description task with special constraints was used to provoke hesitation phenomena and speech errors. The transcribed speech sample was segmented into events of one second and each event was assigned to one category of a complex schema especially developed for this purpose. The main results were: conceptual planning engages bilateral activation of the precuneus. Successful lexical retrieval is accompanied – particularly in comparison to unsolved word-finding difficulties – by the left middle and superior temporal gyrus. Syntactic completeness is reflected in activation of the left inferior frontal gyrus (IFG) (area 44). In sum, the method has proven to be useful for investigating the neural correlates of lexical and syntactic phenomena in an overt picture description task. This opens up new prospects for the analysis of spontaneous language production during fMRI. Y1 - 2012 U6 - https://doi.org/10.1016/j.neuroimage.2012.03.087 SN - 1522-2586 VL - 61 IS - 3 SP - 702 EP - 714 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Hartmann, Axel A1 - Kallweit, Stephan A1 - Feldusen, Antje A1 - Schröder, Wolfgang T1 - Detection of upstream propagating sound waves at buffet flow using high-speed PIV BT - 16th International Symposium on Applications of Laser Techniques to Fluid Mechanics ; 9th to 12th July 2012 Lisbon, Portugal Y1 - 2012 N1 - Aerodynamisches Institut ; International Symposium on Applications of Laser Techniques to Fluid Mechanics <16, 2012, Lissabon> ER - TY - GEN A1 - Frauenrath, Tobias A1 - Pfeiffer, Harald A1 - Hezel, Fabian A1 - Dieringer, Matthias A. A1 - Winter, Lukas A1 - Gräßl, Andreas A1 - Santoro, Davide A1 - Özerdem, Celal A1 - Renz, Wolfgang A1 - Greiser, Andreas A1 - Niendorf, Thoralf T1 - Lessons learned from cardiac MRI at 7.0 T: LV function assessment at 3.0 T using local multi-channel transceiver coil arrays T2 - 2012 ISMRM Annual Meeting Proceedings N2 - Cardiac MR (CMR) is of proven clinical value but also an area of vigorous ongoing research since image quality is not always exclusively defined by signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). Recent developments of CMR at 7.0 T have been driven by pioneering explorations into novel multichannel transmit and receive coil array technology to tackle the challenges B1+-field inhomogeneities, to offset specific-absorption rate (SAR) constraints and to reduce banding artifacts in SSFP imaging. For this study, recognition of the benefits and performance of local surface Tx/Rx-array structures recently established at 7.0 T inspired migration to 3.0 T, where RF inhomogeneities and SAR limitations encountered in routine clinical CMR, though somewhat reduced versus the 7.0 T situation, remain significant. For all these reasons, this study was designed to build and examine the feasibility of a local four channel Tx/Rx cardiac coil array for anatomical and functional cardiac imaging at 3.0 T. For comparison, a homebuilt 4 channel Rx cardiac coil array exhibiting the same geometry as the Tx/Rx coil and a Rx surface coil array were used. Y1 - 2012 SN - 1545-4428 N1 - ISMRM 20th Annual Meeting & Exhibition, 5-11 May 2012, Melbourne, Australia ER - TY - CHAP A1 - Ferrein, Alexander A1 - Kallweit, Stephan A1 - Lautermann, Mark T1 - Towards an autonomous pilot system for a tunnel boring machine T2 - 5th Robotics and Mechatronics Conference of South Africa (ROBMECH) : 26 - 27 November 2012 ; CSIR International Conference Centre Gauteng South Africa Y1 - 2012 SN - 978-1-4673-5183-6 N1 - Robotics and Mechatronics Conference of South Africa <5, 2012, Johannesburg> ; ROBOMECH <5, 2012, Johannesburg> PB - IEEE CY - Piscataway, NJ ER - TY - CHAP A1 - Fuchs, Britta A1 - Ritz, Thomas A1 - Strauch, Jakob ED - Obaidat, Mohammad S. T1 - Usability of mobile applications : dissemination of usability engineering in small and medium enterprises T2 - Proceedings of the International Conference on Data Communication Networking, e-Business and Optical Communication Systems : Rome, Italy, 24 - 27 July, 2012 ; [integrated in the ICETE (International Conference on e-Business and Telecommunications)] Y1 - 2012 SN - 978-989-8565-23-5 N1 - Nebentitel: DCNET; ICE-B; OPTICS SP - 272 EP - 277 PB - SciTePress CY - [Lissabon] ER - TY - JOUR A1 - Scheer, Nico A1 - Kapelyukh, Yury A1 - Rode, Anja A1 - Buechel, Sandra A1 - Wolf, C. Roland T1 - Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines JF - Molecular Pharmacology N2 - Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction. Y1 - 2012 U6 - https://doi.org/10.1124/mol.112.080036 SN - 1521-0111 VL - 82 IS - 6 SP - 1022 EP - 1029 PB - ASPET CY - Bethesda, Md. ER - TY - CHAP A1 - Nötzold, K. A1 - Uphues, A. A1 - Wegener, R. A1 - Soter, S. A1 - Fink, K. A1 - Bragard, Michael A1 - Griessel, R. T1 - Inverter based test setup for LVRT verification of a full-scale 2 MW wind power converter T2 - EPE Joint Wind Energy and T&D Chapters Seminar : 28th and 29th of June 2012, in the Utzon Centre, Aalborg, Denmark ; papers, posters, presentations. - Session 2: Grid connection, compliance Y1 - 2012 PB - EPE Association CY - Brussels ER - TY - GEN A1 - Frauenrath, Tobias A1 - Fuchs, Katharina A1 - Hezel, Fabian A1 - Dieringer, Matthias A. A1 - Rieger, Jan A1 - Niendorf, Thoralf T1 - Improved cardiac triggering by combining multiple physiological signals: a cardiac MR feasibility study at 7.0 T T2 - 2012 ISMRM Annual Meeting Proceedings N2 - In current clinical cardiovascular MR (CMR) practice cardiac motion is commonly dealt with using ECG based synchronization. However, ECG is corrupted by magneto-hydrodynamic (MHD) effects in magnetic fields. This leads to artifacts in the ECG trace and evokes severe T-wave elevations, which might be misinterpreted as R-waves resulting in erroneous triggering. At (ultra)high field strengths, the propensity of ECG recordings to MHD effects is further pronounced. Pulse oximetry (POX) being inherently sensitive to blood oxygenation provides an alternative approach for cardiac gating. However, due to the travel time of the blood the peak of maximum oxygenation and hence the trigger is delayed by approx. 300 ms with respect to the ECG's R-wave. Also the peak of maximum oxygenation shows a jitter of up to 65 ms. Alternative triggering approaches include acoustic cardiac triggering (ACT). In current clinical practice cardiac gating / triggering commonly relies on using single physiological signals only. Realizing this limitation this study proposes a combined triggering approach which exploits multiple physiological signals including ECG, POX or ACT to track cardiac activity. The feasibility of the coupled approach is examined for LV function assessment at 7.0 T. For this purpose, breath-held 2D-CINE imaging in conjunction with cardiac synchronization was performed paralleled by real time logging of physiological waveforms to track (mis)synchronization between the cardiac cycle and data acquisition. Combinations of the ECG, POX and ACT signals were evaluated and processed in real time to facilitate reliable trigger information. Y1 - 2012 SN - 1545-4428 N1 - ISMRM 20th Annual Meeting & Exhibition, 5-11 May 2012, Melbourne, Australia ER -