TY  - JOUR
A1  - Buniatyan, Vahe V.
A1  - Abouzar, Maryam H.
A1  - Martirosyan, Norayr W.
A1  - Schubert, Jürgen
A1  - Gevorgian, Spartak
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique
JF  - Physica Status Solidi (A). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 824
EP  - 830
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Schiek, B.
T1  - Robust Algorithms for Txx Network Analyzer Self-Calibration Procedures
JF  - IEEE transactions on instrumentation and measurement : IM / Institute of Electrical and Electronics Engineers, Instrumentation and Measurement Group. 43 (1994), H. 1
Y1  - 1994
SN  - 0018-9456
SP  - 18
EP  - 23
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Fiorini, G. L.
A1  - Lensa, W. von
A1  - Burgazzi, L.
T1  - Reliability Methods for Passive Safety Functions
JF  - Proceedings of the SMiRT 14 Post Conference Seminar No 18 on Passive Safety Features in Nuclear Installations
Y1  - 1997
CY  - Pisa
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Heitzer, M.
T1  - Limit and Shakedown Analysis Using a General Purpose Finite Element Code
JF  - Proceedings of NAFEMS World Congress '97 on Design, Simulation & Optimisation : reliability & applicability of computational methods ; Stuttgart, Germany, 9 - 11 April 1997
Y1  - 1997
SN  - 1-87437-620-4
SP  - 522
EP  - 533
PB  - NAFEMS
CY  - Glasgow
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Razavi, A.
A1  - Bäcker, Matthias
A1  - Bijnens, N.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Moritz, W.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Nanocrystalline-diamond thin films with high pH and penicillin sensitivity prepared on a capacitive Si–SiO2 structure
JF  - Electrochimica Acta. 54 (2009), H. 25
Y1  - 2009
SN  - 0013-4686
SP  - 5981
EP  - 5985
ER  - 
TY  - CHAP
A1  - Valero, Daniel
A1  - Kramer, Matthias
A1  - Bung, Daniel Bernhard
A1  - Chanson, Hubert
T1  - A stochastic bubble generator for air-water flow research
T2  - E-proceedings of the 38th IAHR World Congress, September 1-6, 2019, Panama City, Panama
Y1  - 2019
U6  - https://doi.org/10.3850/38WC092019-0909
SP  - 5714
EP  - 5721
ER  - 
TY  - CHAP
A1  - Becker, Jörg
A1  - Eggert, Mathias
A1  - Fleischer, Stefan
A1  - Knackstedt, Ralf
T1  - How to Teach Regulatory Compliant Data Warehouse Engineering?
T2  - Proceedings of the Nineteenth Americas Conference on Information Systems, Chicago, Illinois, August 15-17, 2013.
Y1  - 2013
N1  - AMCIS 2013 Proceedings
ER  - 
TY  - JOUR
A1  - Ferrein, Alexander
A1  - Siebel, Nils T.
A1  - Steinbauer, Gerald
T1  - Hybrid control for autonomous systems — Integrating learning, deliberation and reactive control
JF  - Robotics and Autonomous Systems
Y1  - 2010
SN  - 0921-8890
VL  - 58
IS  - 9
SP  - 1037
EP  - 1038
ER  - 
TY  - BOOK
A1  - Laack, Walter van
T1  - Greater Than the Entire Universe
Y1  - 2022
SN  - 978-3-936624-52-6
PB  - van Laack GmbH
CY  - Aachen
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - https://doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
A1  - Ibrahim, Irfan
T1  - Improvements in the flicker noise reduction technique for osillator designs / Ibrahim, Irfan ; Heuermann, Holger
JF  - European Microwave Conference, 2009 : EuMC 2009 ; Sept. 29, 2009 - Oct. 1, 2009, Rome, Italy ; part of European Microwave Week (EuMW) / sponsored by EuMA, European Microwave Association ... Endorsed by IEEE
Y1  - 2009
SN  - 978-1-4244-4748-0
N1  - EuMC 2009
SP  - 1215
EP  - 1218
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - JOUR
A1  - Gun, Jenny
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Katz, Evgeny
T1  - Field-Effect Nanoparticle-Based Glucose Sensor on a Chip: Amplification Effect of Coimmobilized Redox Species
JF  - Electroanalysis. 20 (2008), H. 16
Y1  - 2008
SN  - 1521-4109
SP  - 1748
EP  - 1753
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, T.
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]
Y1  - 2000
SN  - 87-89935-50-0
N1  - Eurosensors ; (14, 2000, København) ; Eurosensors ; (14 : ; 2000.08.27-30 : ; Copenhagen) ; European Conference on Solid-State Transducers ; (14 : ; 2000.08.27-30 : ; Copenhagen)
SP  - 27
EP  - 30
PB  - MIC, Mikroelektronik Centret
CY  - Lyngby, Denmark
ER  - 
TY  - JOUR
A1  - Heuermann, Holger
T1  - A Synthesis Technique for Mono- and Mixed-Mode Symmetrical Filter
JF  - Conference proceedings : Tuesday 12th, Wednesday 13th and Thursday 14th October, [RAI International Exhibition and Congress Centre, Amsterdam ; part of European Microwave Week 2004] / EuMA, European Microwave Association . Vol. 1
Y1  - 2004
SN  - 1-580-53992-0
N1  - European Microwave Conference ; (34, 2004, Amsterdam) ; European Microwave Week ; (7, 2004, Amsterdam)
SP  - 309
EP  - 312
PB  - Horizon House Publ
CY  - London
ER  - 
TY  - CHAP
A1  - Kerpen, N. B.
A1  - Bung, Daniel Bernhard
A1  - Schlurmann, Torsten
ED  - Janssen, Robert
T1  - Physical model investigations of ships passing through a lock
T2  - Hydraulic structures: useful water harvesting systems or relics? : Third International Junior Researcher and Engineer Workshop on Hydraulic Structures (IJREWHS'10) : Edinburgh, Scotland, U.K., 2-3 May 2010
Y1  - 2010
SN  - 9781742720159
SP  - 93
EP  - 100
PB  - School of Civil Engineeering, The University of Queensland
CY  - Brisbane
ER  - 
TY  - CHAP
A1  - Bung, Daniel Bernhard
T1  - Non-intrusive measuring of air-water flow properties in self-aerated stepped spillway flow
T2  - Balance and uncertainty - water in a changing world :  proceedings of the 34th IAHR world congress ; 33rd Hydrology and Water Resources Symposium ; 10th Conference on Hydraulics in Water Engineering ; 26 June - 1 July 2011, Brisbane, Australia
Y1  - 2011
SN  - 978-0-85825-868-6
SP  - 2380
EP  - 2387
ER  - 
TY  - CHAP
A1  - Bung, Daniel Bernhard
A1  - Schlenkhoff, Andreas
ED  - Pagliara, Stefano
T1  - Optimization of the reaeration potential on embankment stepped spillways in skimming flow regime
T2  - Hydraulic structures : proceedings of the second International Junior Researcher and Engineer Workshop on Hydraulic Structures, Pisa, Italy, 30 July-1 August 2008
Y1  - 2008
SN  - 978-88-8492-568-8
SP  - 97
EP  - 106
ER  - 
TY  - CHAP
A1  - Schlenkhoff, Andreas
A1  - Bung, Daniel Bernhard
T1  - Prediction of oxygen transfer in self-aerated skimming flow on embankment stepped spillways
T2  - Water engineering for sustainable environment : 33rd IAHR congress ; 9 - 14 August 2009, Vancouver, British Columbia, Canada
Y1  - 2009
SN  - 9789078046080
SP  - 1 CD-ROM
ER  - 
TY  - CHAP
A1  - Bung, Daniel Bernhard
A1  - Schlenkhoff, Andreas
A1  - Oertel, M.
T1  - Self-aerated skimming flow on embankment stepped spillways
T2  - Water engineering for sustainable environment : 33rd IAHR congress ; 9 - 14 August 2009, Vancouver, British Columbia, Canada
Y1  - 2009
SN  - 9789078046080
SP  - 1 CD-ROM
ER  - 
TY  - CHAP
A1  - Oertel, M.
A1  - Bung, Daniel Bernhard
A1  - Schlenkhoff, Andreas
T1  - Flash flood awareness and prevention
T2  - Water engineering for sustainable environment : 33rd IAHR congress ; 9 - 14 August 2009, Vancouver, British Columbia, Canada
Y1  - 2009
SN  - 9789078046080
SP  - 1 CD-ROM
ER  - 
TY  - JOUR
A1  - Honarvarfard, Elham
A1  - Gamella, Maria
A1  - Channaveerappa, Devika
A1  - Darie, Costel C.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - Electrochemically Stimulated Insulin Release from a Modified Graphene–functionalized Carbon Fiber Electrode
JF  - Electroanalysis
N2  - A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9–10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of −1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.
Y1  - 2017
U6  - https://doi.org/10.1002/elan.201700095
SN  - 1521-4109
VL  - 29
IS  - 6
SP  - 1543
EP  - 1553
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Hardt, G.
A1  - Käver, L.
A1  - Willenberg, H.S.
A1  - Kröger, J.-C.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling
JF  - Sensor and Actuators B: Chemical
N2  - A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician.
Y1  - 2018
U6  - https://doi.org/10.1016/j.snb.2018.05.136
SN  - 0925-4005
VL  - 272
SP  - 21
EP  - 27
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Kuhlen, Max
A1  - Digel, Ilya
ED  - Erni, Daniel
ED  - Fischerauer, Alice
ED  - Himmel, Jörg
ED  - Seeger, Thomas
ED  - Thelen, Klaus
T1  - Fluorescence signatures and detection limits of ubiquitous terrestrial bio-compounds
T2  - 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West
Y1  - 2017
SN  - 978-3-9814801-9-1
U6  - https://doi.org/10.17185/duepublico/43984
N1  - A young researchers track of the 7th IEEE Workshop & SENSORICA 2017
SP  - 102
EP  - 103
PB  - Universität Duisburg-Essen
CY  - Duisburg
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schultze, J. W.
A1  - Schöning, Michael Josef
T1  - Application of a (bio-)chemical sensor (ISFET) for the detection of physical parameters in liquids
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SP  - 3289
EP  - 3297
ER  - 
TY  - INPR
A1  - Grieger, Niklas
A1  - Mehrkanoon, Siamak
A1  - Bialonski, Stephan
T1  - Preprint: Data-efficient sleep staging with synthetic time series pretraining
T2  - arXiv
N2  - Analyzing electroencephalographic (EEG) time series can be challenging, especially with deep neural networks, due to the large variability among human subjects and often small datasets. To address these challenges, various strategies, such as self-supervised learning, have been suggested, but they typically rely on extensive empirical datasets. Inspired by recent advances in computer vision, we propose a pretraining task termed "frequency pretraining" to pretrain a neural network for sleep staging by predicting the frequency content of randomly generated synthetic time series. Our experiments demonstrate that our method surpasses fully supervised learning in scenarios with limited data and few subjects, and matches its performance in regimes with many subjects. Furthermore, our results underline the relevance of frequency information for sleep stage scoring, while also demonstrating that deep neural networks utilize information beyond frequencies to enhance sleep staging performance, which is consistent with previous research. We anticipate that our approach will be advantageous across a broad spectrum of applications where EEG data is limited or derived from a small number of subjects, including the domain of brain-computer interfaces.
Y1  - 2024
ER  - 
TY  - JOUR
A1  - Duong, Minh Tuan
A1  - Nguyen, Nhu Huynh
A1  - Tran, Thanh Ngoc
A1  - Tolba, R. H.
A1  - Staat, Manfred
T1  - Influence of refrigerated storage on tensile mechanical properties of porcine liver and spleen
JF  - International biomechanics
Y1  - 2015
U6  - https://doi.org/10.1080/23335432.2015.1049295
SN  - 2333-5432
VL  - Vol. 2
IS  - Iss. 1
SP  - 79
EP  - 88
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Staat, Manfred
A1  - Sponagel, Stefan
A1  - Nguyen, Nhu Huynh
T1  - Experiment and material model for soft tissue materials
JF  - Constitutive  models for rubber VI : proceedings of the sixth European Conference on Constitutive Models for Rubber, Dresden, Germany, 7 - 10 September 2009 / eds. Gert Heinrich ...
Y1  - 2010
SN  - 978-0-415-56327-7
SP  - 465
EP  - 470
PB  - CRC Press
CY  - Boca Raton [u.a.]
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Delle, L.
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Zang, Werner
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Electrochemical sensor array for bioprocess monitoring
JF  - Electrochimica Acta (2011)
Y1  - 2011
VL  - 56
IS  - 26
SP  - 9673
EP  - 9678
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Näther, Niko
A1  - Auger, V.
A1  - Poghossian, Arshak
A1  - Koudelka-Hep, M.
T1  - Miniaturized flow-through cell with integrated capacitive EIS sensors fabricated at wafer level using Si and Su-8 technologies
JF  - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors
Y1  - 2004
N1  - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba)
SP  - 554
EP  - 555
PB  - Japan Association of Chemical Sensors
CY  - Fukuoka
ER  - 
TY  - JOUR
A1  - Schiffer, Stefan
A1  - Ferrein, Alexander
A1  - Lakemeyer, Gerhard
T1  - Reasoning with Qualitative Positional Information for Domestic Domains in the Situation Calculus
JF  - Journal of Intelligent & Robotic Systems
Y1  - 2011
SN  - 0921-0296
VL  - 63
IS  - 2
SP  - 273
EP  - 300
PB  - Springer
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Stender, Michael
A1  - Ritz, Thomas
T1  - Modeling of business-to-business mobile commerce processes
T2  - Electronic proceedings / ICPR 17, 17th International Conference on Production Research [Blacksburg, Virginia, USA, August 3 - 7, 2003]
Y1  - 2003
SN  - 0-9721257-3-6
CY  - Blacksburg, Va.
ET  - CD-ROM-Ausg.
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Bronder, Thomas
A1  - Wu, Chunsheng
A1  - Scheja, Sabrina
A1  - Jessing, Max
A1  - Metzger-Boddien, Christoph
A1  - Keusgen, Michael
A1  - Poghossian, Arshak
T1  - Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities
JF  - Proceedings
N2  - Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.
Y1  - 2017
U6  - https://doi.org/10.3390/proceedings1080719
SN  - 2504-3900
N1  - This article belongs to the Proceedings of "Proceedings of the 5th International Symposium on Sensor Science (I3S 2017)"
VL  - 1
IS  - 8
SP  - Artikel 719
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Steuer-Dankert, Linda
A1  - Berg, Tobias
A1  - Leicht-Scholten, Carmen
T1  - Breaking the habit – new approaches in engineering education
T2  - Proceedings of the 43rd Annual Conference of the European Society for Engineering Education
N2  - Within the framework of the project a genderand diversity-oriented teaching evaluation and modern, media-supported blended learning approaches were used in order to achieve the intended goals. First research results of the literature and status quo analysis were already implemented and tested in newly designed teaching approaches, for example in a multidisciplinary introductory lecture of civil engineering at RWTH Aachen University.
KW  - teaching
KW  - engineering education
KW  - gender and diversity
KW  - best practice
Y1  - 2015
SN  - 978-2-87352-012-0
N1  - Annual Conference of the European Society for Engineering Education , Orléans , France , SEFI , 2015-06-29 - 2015-07-02
ER  - 
TY  - JOUR
A1  - Mourzina, Y.
A1  - Mai, T.
A1  - Poghossian, Arshak
A1  - Ermolenko, Y.
A1  - Yoshinobu, T.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - K+-selective field-effect sensors as transducers for bioelectronic applications
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3333
EP  - 3339
ER  - 
TY  - CHAP
A1  - Niemueller, Tim
A1  - Neumann, Tobias
A1  - Henke, Christoph
A1  - Schönitz, Sebastian
A1  - Reuter, Sebastian
A1  - Ferrein, Alexander
A1  - Jeschke, Sabina
A1  - Lakemeyer, Gerhard
T1  - International Harting Open Source Award 2016: Fawkes for the RoboCup Logistics League
T2  - RoboCup 2016: RoboCup 2016: Robot World Cup XX. RoboCup 2016
Y1  - 2017
SN  - 978-3-319-68792-6
U6  - https://doi.org/10.1007/978-3-319-68792-6_53
N1  - Lecture Notes in Computer Science, LNCS, Vol 9776
SP  - 634
EP  - 642
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Platen, J.
A1  - Schöning, Michael Josef
T1  - Towards self-aligned nanostructures by means of layerexpansion technique
JF  - Electrochimica Acta. 51 (2005), H. 5
Y1  - 2005
SN  - 0013-4686
SP  - 838
EP  - 843
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - A Solution to the Scheduling Problem Taking into Account Quality
JF  - Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GMÖOR]. Peter Gritzmann ... (eds.)
Y1  - 1991
SN  - 3790806080
N1  - Symposium on Operations Research ; (16, 1991, Trier)
SP  - 373
EP  - 375
PB  - Physica-Verl.
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Iken, Heiko
A1  - Johnen, Anna Lynn
A1  - Richstein, Benjamin
A1  - Hellmich, Lena
A1  - Poghossian, Arshak
A1  - Knoch, Joachim
A1  - Schöning, Michael Josef
T1  - Miniaturized pH-Sensitive Field-Effect Capacitors with Ultrathin Ta₂O₅ Films Prepared by Atomic Layer Deposition
JF  - physica status solidi (a) applications and materials science
N2  - Miniaturized electrolyte–insulator–semiconductor capacitors (EISCAPs) with ultrathin gate insulators have been studied in terms of their pH-sensitive sensor characteristics: three different EISCAP systems consisting of Al–p-Si–Ta2O5(5 nm), Al–p-Si–Si3N4(1 or 2 nm)–Ta2O5 (5 nm), and Al–p-Si–SiO2(3.6 nm)–Ta2O5(5 nm) layer structures are characterized in buffer solution with different pH values by means of capacitance–voltage and constant capacitance method. The SiO2 and Si3N4 gate insulators are deposited by rapid thermal oxidation and rapid thermal nitridation, respectively, whereas the Ta2O5 film is prepared by atomic layer deposition. All EISCAP systems have a clear pH response, favoring the stacked gate insulators SiO2–Ta2O5 when considering the overall sensor characteristics, while the Si3N4(1 nm)–Ta2O5 stack delivers the largest accumulation capacitance (due to the lower equivalent oxide thickness) and a higher steepness in the slope of the capacitance–voltage curve among the studied stacked gate insulator systems.
KW  - atomic layer deposition
KW  - capacitive field-effect sensors
KW  - pH sensors
KW  - ultrathin gate insulators
Y1  - 2022
U6  - https://doi.org/10.1002/pssa.202100660
SN  - 1862-6319
N1  - Corresponding author: Michael J. Schöning
VL  - 219
IS  - 8
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Goßmann, Matthias
A1  - Frotscher, Ralf
A1  - Linder, Peter
A1  - Bayer, Robin
A1  - Epple, U.
A1  - Staat, Manfred
A1  - Temiz Artmann, Aysegül
A1  - Artmann, Gerhard
T1  - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells
JF  - Cellular physiology and biochemistry
N2  - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.
KW  - Inotropic compounds
KW  - Pharmacology
KW  - Ion channels
KW  - CellDrum
KW  - Heart tissue culture
KW  - Induced pluripotent stem cells
KW  - Cardiac myocytes
Y1  - 2016
U6  - https://doi.org/10.1159/000443124
SN  - 1421-9778 (Online)
SN  - 1015-8987 (Print)
VL  - 38
IS  - 3
SP  - 1182
EP  - 1198
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Scheja, Sabrina
A1  - Wu, Chunsheng
A1  - Keusgen, Michael
A1  - Mewes, Dieter
A1  - Schöning, Michael Josef
T1  - DNA Immobilization and Hybridization Detection by the Intrinsic Molecular Charge Using Capacitive Field-Effect Sensors Modified with a Charged Weak Polyelectrolyte Layer
JF  - Applied Materials & Interfaces
N2  - Miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge favor the semiconductor field-effect platform as one of the most attractive approaches for the development of label-free DNA chips. In this work, a capacitive field-effect EIS (electrolyte–insulator–semiconductor) sensor covered with a layer-by-layer prepared, positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)) was used for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization. The negatively charged probe single-stranded DNA (ssDNA) molecules were electrostatically adsorbed onto the positively charged PAH layer, resulting in a preferentially flat orientation of the ssDNA molecules within the Debye length, thus yielding a reduced charge-screening effect and a higher sensor signal. Each sensor-surface modification step (PAH adsorption, probe ssDNA immobilization, hybridization with complementary target DNA (cDNA), reducing an unspecific adsorption by a blocking agent, incubation with noncomplementary DNA (ncDNA) solution) was monitored by means of capacitance–voltage and constant-capacitance measurements. In addition, the surface morphology of the PAH layer was studied by atomic force microscopy and contact-angle measurements. High hybridization signals of 34 and 43 mV were recorded in low-ionic strength solutions of 10 and 1 mM, respectively. In contrast, a small signal of 4 mV was recorded in the case of unspecific adsorption of fully mismatched ncDNA. The density of probe ssDNA and dsDNA molecules as well as the hybridization efficiency was estimated using the experimentally measured DNA immobilization and hybridization signals and a simplified double-layer capacitor model. The results of field-effect experiments were supported by fluorescence measurements, verifying the DNA-immobilization and hybridization event.
Y1  - 2015
U6  - https://doi.org/10.1021/acsami.5b05146
VL  - 36
IS  - 7
SP  - 20068
EP  - 20075
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Bäcker, Matthias
A1  - Raue, Markus
A1  - Schusser, Sebastian
A1  - Jeitner, C.
A1  - Breuer, L.
A1  - Wagner, P.
A1  - Poghossian, Arshak
A1  - Förster, Arnold
A1  - Mang, Thomas
A1  - Schöning, Michael Josef
T1  - Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films
JF  - Physica Status Solidi  (a)
N2  - Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3–12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.
Y1  - 2012
U6  - https://doi.org/10.1002/pssa.201100763
SN  - 1862-6319
VL  - 209
IS  - 5
SP  - 839
EP  - 845
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Label-free detection of double-stranded DNA molecules with polyelectrolyte-modified capacitive field-effect sensors
T1  - Markierungsfreie Detektion doppelsträngiger DNA Moleküle mit Hilfe von Polyelektrolyt-modifizierten kapazitiven Feldeffekt-Sensoren
JF  - tm - Technisches Messen
N2  - In this study, polyelectrolyte-modified field-effect-based electrolyte-insulator-semiconductor (EIS) devices have been used for the label-free electrical detection of double-stranded deoxyribonucleic acid (dsDNA)molecules. The sensor-chip functionalization with a positively charged polyelectrolyte layer provides the possibility of direct adsorptive binding of negatively charged target DNA oligonucleotides onto theSiO2-chip surface.EIS sensors can be utilized as a tool to detect surface-charge changes; the electrostatic adsorption of oligonucleotides onto the polyelectrolyte layer leads to a measureable surface-potential change. Signals of 39mV have been recorded after the incubation with the oligonucleotide solution. Besides the electrochemical experiments, the successful adsorption of dsDNA onto the polyelectrolyte layer has been verified via fluorescence microscopy. The presented results demonstrate that the signal recording of EISchips, which are modified with a polyelectrolyte layer, canbe used as a favorable approach for a fast, cheap and simple detection method for dsDNA.
Y1  - 2017
U6  - https://doi.org/10.1515/teme-2017-0015
VL  - 84
IS  - 10
SP  - 628
EP  - 634
PB  - De Gruyter
CY  - Oldenbourg
ER  - 
TY  - JOUR
A1  - Jablonski, Melanie
A1  - Poghossian, Arshak
A1  - Severin, Robin
A1  - Keusgen, Michael
A1  - Wege, Christian
A1  - Schöning, Michael Josef
T1  - Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles
JF  - Micromachines
N2  - Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles.
KW  - capacitive field-effect sensor
KW  - plant virus detection
KW  - tobacco mosaic virus (TMV)
KW  - TMV adsorption
KW  - Ta₂O₅ gate
Y1  - 2021
U6  - https://doi.org/10.3390/mi12010057
VL  - 12
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Valero, Daniel
A1  - Bung, Daniel Bernhard
T1  - Sensitivity of turbulent Schmidt number and turbulence model to simulations of jets in crossflow
JF  - Environmental Modelling and Software
N2  - Environmental discharges have been traditionally designed by means of cost-intensive and time-consuming experimental studies. Some extensively validated models based on an integral approach have been often employed for water quality problems, as recommended by USEPA (i.e.: CORMIX). In this study, FLOW-3D is employed for a full 3D RANS modelling of two turbulent jet-to-crossflow cases, including free surface jet impingement. Results are compared to both physical modelling and CORMIX to better assess model performance. Turbulence measurements have been collected for a better understanding of turbulent diffusion's parameter sensitivity. Although both studied models are generally able to reproduce jet trajectory, jet separation downstream of the impingement has been reproduced only by RANS modelling. Additionally, concentrations are better reproduced by FLOW-3D when the proper turbulent Schmidt number is used. This study provides a recommendation on the selection of the turbulence model and the turbulent Schmidt number for future outfall structures design studies.
Y1  - 2016
U6  - https://doi.org/10.1016/j.envsoft.2016.04.030
SN  - 1364-8152 (electronic)
VL  - 82
SP  - 218
EP  - 228
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kurulgan Demirci, Eylem
A1  - Demirci, T.
A1  - Trzewik, Jürgen
A1  - Linder, Peter
A1  - Karakulah, G.
A1  - Artmann, Gerhard
A1  - Sakizli, M.
A1  - Temiz Artmann, Aysegül
T1  - Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation
JF  - Cellular and molecular bioengineering. 4 (2011), H. 1
Y1  - 2011
SN  - 1865-5025
SP  - 46
EP  - 55
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
T1  - pH and ion sensitivity of a field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with polyelectrolyte multilayers
JF  - Journal of Solid State Electrochemistry. 13 (2009), H. 1
Y1  - 2009
SN  - 1433-0768
N1  - This manuscript is an invited paper to the special issue on “Solid-state potentiometric sensors” (Guest editor: Johan Bobacka).
SP  - 115
EP  - 122
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Naser, S.
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors <13, 1999, 's-Gravenhage> ; Eurosensors <13, 1999, The Hague> ;  European Conference on Solid-State Transducers <13, 1999, The Hague>
SP  - 573
EP  - 576
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Luft, Angela
A1  - Luft, Nils
A1  - Arntz, Kristian
T1  - A basic description logic for service-oriented architecture in factory planning and operational control in the age of industry 4.0
JF  - Applied Sciences
N2  - Manufacturing companies across multiple industries face an increasingly dynamic and unpredictable environment. This development can be seen on both the market and supply side. To respond to these challenges, manufacturing companies must implement smart manufacturing systems and become more flexible and agile. The flexibility in operational planning regarding the scheduling and sequencing of customer orders needs to be increased and new structures must be implemented in manufacturing systems’ fundamental design as they constitute much of the operational flexibility available. To this end, smart and more flexible solutions for production planning and control (PPC) are developed. However, scheduling or sequencing is often only considered isolated in a predefined stable environment. Moreover, their orientation on the fundamental logic of the existing IT solutions and their applicability in a dynamic environment is limited. This paper presents a conceptual model for a task-based description logic that can be applied to factory planning, technology planning, and operational control. By using service-oriented architectures, the goal is to generate smart manufacturing systems. The logic is designed to allow for easy and automated maintenance. It is compatible with the existing resource and process allocation logic across operational and strategic factory and production planning.
KW  - manufacturing data model
KW  - production planning and control
KW  - manufacturing flexibility
KW  - technology planning
KW  - SOA
KW  - service-oriented architectures
KW  - factory planning
Y1  - 2023
U6  - https://doi.org/10.3390/app13137610
SN  - 2076-3417
N1  - This article belongs to the Special Issue "Smart Industrial System"
VL  - 2023
IS  - 13
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Niemueller, Tim
A1  - Zwilling, Frederik
A1  - Lakemeyer, Gerhard
A1  - Löbach, Matthias
A1  - Reuter, Sebastian
A1  - Jeschke, Sabina
A1  - Ferrein, Alexander
T1  - Cyber-Physical System Intelligence
T2  - Industrial Internet of Things
N2  - Cyber-physical systems are ever more common in manufacturing industries. Increasing their autonomy has been declared an explicit goal, for example, as part of the Industry 4.0 vision. To achieve this system intelligence, principled and software-driven methods are required to analyze sensing data, make goal-directed decisions, and eventually execute and monitor chosen tasks. In this chapter, we present a number of knowledge-based approaches to these problems and case studies with in-depth evaluation results of several different implementations for groups of autonomous mobile robots performing in-house logistics in a smart factory. We focus on knowledge-based systems because besides providing expressive languages and capable reasoning techniques, they also allow for explaining how a particular sequence of actions came about, for example, in the case of a failure.
KW  - Smart factory
KW  - Industry 4.0
KW  - Multi-robot systems
KW  - Autonomous mobile robots
KW  - RoboCup
Y1  - 2017
SN  - 978-3-319-42559-7
U6  - https://doi.org/10.1007/978-3-319-42559-7_17
N1  - Springer Series in Wireless Technology
SP  - 447
EP  - 472
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Lüth, Hans
T1  - Semiconductor-based field-effect structures for chemical sensing
Y1  - 2001
SP  - 188
EP  - 198
ER  -