TY - JOUR A1 - Ge, B. A1 - Meyer, T. A1 - Schöning, Michael Josef A1 - Wollenberger, U. A1 - Lisdat, F., T1 - Cytochrome c‘ from Chromatium vinosum on gold electrodes JF - Electrochemistry Communications. 2 (2000), H. 8 Y1 - 2000 SN - 1388-2481 SP - 557 EP - 561 ER - TY - THES A1 - Geenen, Eva-Maria T1 - Studies of Epstein-Barr virus EBNA2 and its interactions with host cell factors T1 - Etude de la protéine EBNA2 du virus Epstein-Barr et ses interactions avec les facteurs de la cellule hôte Y1 - 2013 N1 - Thesis PB - Université de Grenoble CY - Grenoble ER - TY - JOUR A1 - Geier, Christian A1 - Bialonski, Stephan A1 - Elger, Christian E. A1 - Lehnertz, Klaus T1 - How important is the seizure onset zone for seizure dynamics? JF - Seizure Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.seizure.2014.10.013 SN - 1059-1311 VL - 25 SP - 160 EP - 166 ER - TY - JOUR A1 - Geier, Christian A1 - Lehnertz, Klaus A1 - Bialonski, Stephan T1 - Time-dependent degree-degree correlations in epileptic brain networks: from assortative to dissortative mixing JF - Frontiers in Human Neuroscience Y1 - 2015 U6 - http://dx.doi.org/10.3389/fnhum.2015.00462 SN - 1662-5161 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Gerhards, M. A1 - Belloum, A. A1 - Berretz, F. A1 - Sander, Volker A1 - Skorupa, S. T1 - A history-tracing XML-based provenance framework for workflows Y1 - 2010 SN - 978-1-4244-8989-3 N1 - Workflows in Support of Large-Scale Science (WORKS), 2010 5th Workshop on SP - 1 EP - 10 ER - TY - JOUR A1 - Gerhards, M. A1 - Skorupa, S. A1 - Sander, Volker A1 - Belloum, A. A1 - Vesunin, D. A1 - Benabdelkader, A. T1 - HisT/PLIER : A Two-Fold Provenance Approach for Grid-Enabled Scientific Workflows Using WS-VLAM JF - 12th IEEE/ACM International Conference on Grid Computing (GRID), 2011 Y1 - 2011 U6 - http://dx.doi.org/10.1109/Grid.2011.39 SP - 224 EP - 225 PB - IEEE CY - New York ER - TY - JOUR A1 - Gerhards, M. A1 - Skorupa, S. A1 - Sander, Volker A1 - Pfeiffer, P. A1 - Belloum, A. T1 - Towards a security framework for a WS-HumanTask processor JF - 7th International Conference on Network and Service Management (CNSM), 2011 Paris Y1 - 2011 SN - 978-3-901882-44-9 SP - 1 EP - 5 PB - IEEE CY - New York ER - TY - CHAP A1 - Gerhards, Michael A1 - Sander, Volker A1 - Belloum, Adam ED - Zimmermann, Wolf ED - Lee, Yong Woo ED - Demchenko, Yuri T1 - About the flexible Migration of Workflow Tasks to Clouds : Combining on- and off-premise Executions of Applications T2 - CLOUD COMPUTING 2012 : The Third International Conference on Cloud Computing, GRIDs, and Virtualization ; July 22-27, 2012 - Nice, France N2 - An increasing number of applications target their executions on specific hardware like general purpose Graphics Processing Units. Some Cloud Computing providers offer this specific hardware so that organizations can rent such resources. However, outsourcing the whole application to the Cloud causes avoidable costs if only some parts of the application benefit from the specific expensive hardware. A partial execution of applications in the Cloud is a tradeoff between costs and efficiency. This paper addresses the demand for a consistent framework that allows for a mixture of on- and off-premise calculations by migrating only specific parts to a Cloud. It uses the concept of workflows to present how individual workflow tasks can be migrated to the Cloud whereas the remaining tasks are executed on-premise. KW - Workflow Orchestration KW - Workflow KW - Grid Computing KW - Cloud Service Broker KW - Cloud Computing Y1 - 2012 SN - 978-1-61208-216-5 SP - 82 EP - 87 PB - IARIA Journals ER - TY - CHAP A1 - Gerhards, Michael A1 - Sander, Volker A1 - Belloum, Adam T1 - Seamlessly enabling the use of cloud resources in workflows T2 - Cloud Computing 2013 : The Fourth International Conference on Cloud Computing, GRIDs, and Virtualization : May 27 - June 1, 2013 - Valencia, Spain Y1 - 2013 SN - 978-1-61208-271-4 SP - 108 EP - 114 PB - Curren CY - Red Hook, NY ER - TY - JOUR A1 - Gerhards, Michael A1 - Sander, Volker A1 - Zivkovic, Miroslav A1 - Belloum, Adam A1 - Bubak, Marian T1 - New approach to allocation planning of many‐task workflows on clouds JF - Concurrency and Computation: Practice and Experience N2 - Experience has shown that a priori created static resource allocation plans are vulnerable to runtime deviations and hence often become uneconomic or highly exceed a predefined soft deadline. The assumption of constant task execution times during allocation planning is even more unlikely in a cloud environment where virtualized resources vary in performance. Revising the initially created resource allocation plan at runtime allows the scheduler to react on deviations between planning and execution. Such an adaptive rescheduling of a many-task application workflow is only feasible, when the planning time can be handled efficiently at runtime. In this paper, we present the static low-complexity resource allocation planning algorithm (LCP) applicable to efficiently schedule many-task scientific application workflows on cloud resources of different capabilities. The benefits of the presented algorithm are benchmarked against alternative approaches. The benchmark results show that LCP is not only able to compete against higher complexity algorithms in terms of planned costs and planned makespan but also outperforms them significantly by magnitudes of 2 to 160 in terms of required planning time. Hence, LCP is superior in terms of practical usability where low planning time is essential such as in our targeted online rescheduling scenario. Y1 - 2020 U6 - http://dx.doi.org/10.1002/cpe.5404 SN - 1532-0634 VL - 32 IS - 2 Article e5404 SP - 1 EP - 16 PB - Wiley CY - Chichester ER - TY - JOUR A1 - Givanoudi, Stella A1 - Cornelis, Peter A1 - Rasschaert, Geertrui A1 - Wackers, Gideon A1 - Iken, Heiko A1 - Rolka, David A1 - Yongabi, Derick A1 - Robbens, Johan A1 - Schöning, Michael Josef A1 - Heyndrickx, Marc A1 - Wagner, Patrick T1 - Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source JF - Sensors and Actuators B: Chemical Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.snb.2021.129484 SN - 0925-4005 IS - In Press, Journal Pre-proof SP - Article 129484 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Glück, O. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Emons, H. A1 - Hanewinkel, C. A1 - Schumacher, D. A1 - Otto, A. T1 - Trace metal determination with gold microelectrodes fabricated by silicon technology JF - Proceedings of the 11th European Conference on Solid-State Transducers / Eurosensors XI, September 21 - 24, 1997, Warsaw, Poland. [Organised by] Warsaw University of Technology. Vol 2. Y1 - 1997 SN - 83-908335-0-6 N1 - Eurosensors ; (11, 1997, Warszawa) ; Eurosensors - European Conference on Solid-State Transducers ; (11 : ; 1997.09.21-24 : ; Warsaw) SP - 615 EP - 618 PB - Sensor Lab Sp. CY - Warsaw ER - TY - JOUR A1 - Glück, O. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Emons, H. A1 - Otto, A. T1 - Schwermetallbestimmung mittels Widerstandsmessungen und Voltammetrie an Dünnschichtelektroden JF - Chemie- und Biosensoren : aktuelle Anwendungen und Entwicklungstrends / 3. Dresdner Sensor-Symposium, 8. - 10. Dezember 1997, Dresden-Radebeul. J. P. Baselt ... (Hg.) Y1 - 1998 SN - 3-933168-03-1 N1 - Serie Dresdner Beiträge zur Sensorik ; 5 SP - 165 EP - 168 PB - Dresden Univ. Press CY - Dresden ; München ER - TY - JOUR A1 - Glück, O. A1 - Schöning, Michael Josef A1 - Lüth, H. A1 - Otto, A. A1 - Emons, H. T1 - Trace metal determination by dc resistance changes of microstructured thin gold film electrodes JF - Electrochimica Acta. 44 (1999), H. 21-22 Y1 - 1999 SN - 0013-4686 SP - 3761 EP - 3768 ER - TY - CHAP A1 - Goldmann, Jan-Peter A1 - Braunstein, Bjoern A1 - Heinrich, Kai A1 - Sanno, Maximilian A1 - Stäudle, Benjamin A1 - Ritzdorf, Wolfgang A1 - Brüggemann, Gert-Peter A1 - Albracht, Kirsten T1 - Joint work of the take-off leg during elite high jump T2 - Proceedings of the 33th International Conference on Biomechanics in Sports (ISBS) Y1 - 2015 ER - TY - JOUR A1 - Gono, Y. A1 - Lieder, R. M. A1 - Mayer-Böricke, C. A1 - Müller-Veggian, Mattea T1 - High spin states and isomers in ¹⁸⁹,¹⁹¹,¹⁹³ Au JF - Frühjahrstagung ... des Fachausschusses Kernphysik und Hochenergiephysik der DPG (Sektion A: Kernphysik) / Deutsche Physikalische Gesellschaft. 11 (1976) Y1 - 1976 N1 - Verhandlungen der Deutschen Physikalischen Gesellschaft ; 1976=6.R.11,8 SP - 952 ER - TY - JOUR A1 - Gorissen, P. A1 - Staat, Manfred A1 - Laack, Walter van T1 - Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport T1 - Experimental measurement of forces as a contribution to evaluate the effectiveness of shin guards in soccer JF - OUP Zeitschrift für die orthopädische und unfallchirurgische Praxis N2 - Diese Studie beschäftigte sich mit der Dämpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgeführt, der verschiedene Aufschlagkräfte auf die Schoner ermöglichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkräften unterhalb von 5kN erreichen können, dass bei größerer Belastung allerdings Verbesserungsbedarf besteht. Hierfür konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „adäquaten Zusammenspiel von Schale und Polsterung“ der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der Dämpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte. N2 - This study was conducted to test the damping effects of commercially available soccer shin guards on their damping effects. Therefore a pendulum impact apparatus with varying impact forces was used. It became clear that shin guards show the best effect at maximum forces of less than 5kN. There is however a need for improvement at greater impact forces. A good starting point was found in an „appropriate interaction of shell and padding” of the shin guard. It was further clarified that a significant improvement on the damping effect could be achieved at least partially over the last years. KW - Fußball KW - Schienbeinschoner KW - Aufschlagversuch Y1 - 2012 U6 - http://dx.doi.org/10.3238/oup.2012.0010-0015 SN - 2193-5785 VL - 1 IS - 1 SP - 10 EP - 15 PB - Deutscher Ärzte-Verlag CY - Köln ER - TY - JOUR A1 - Gossmann, Matthias A1 - Thomas, Ulrich A1 - Horváth, András A1 - Dragicevic, Elena A1 - Stoelzle-Feix, Sonja A1 - Jung, Alexander A1 - Raman, Aravind Hariharan A1 - Staat, Manfred A1 - Linder, Peter T1 - A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions JF - Journal of Pharmacological and Toxicological Methods Y1 - 2020 U6 - http://dx.doi.org/10.1016/j.vascn.2020.106843 VL - 105 IS - Article 106843 PB - Elsevier CY - New York, NY ER - TY - THES A1 - Goßmann, Matthias T1 - Entwicklung eines autokontraktilen Herzmuskelmodells zur funktionalen Medikamenten- und Toxinforschung Y1 - 2015 N1 - Duisburg, Essen, Universität Duisburg-Essen, Diss., 2015 PB - Universitätsbibliothek Duisburg-Essen CY - Duisburg ; Essen ER - TY - JOUR A1 - Goßmann, Matthias A1 - Frotscher, Ralf A1 - Linder, Peter A1 - Bayer, Robin A1 - Epple, U. A1 - Staat, Manfred A1 - Temiz Artmann, Aysegül A1 - Artmann, Gerhard T1 - Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells JF - Cellular physiology and biochemistry N2 - Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential. KW - Inotropic compounds KW - Pharmacology KW - Ion channels KW - CellDrum KW - Heart tissue culture KW - Induced pluripotent stem cells KW - Cardiac myocytes Y1 - 2016 U6 - http://dx.doi.org/10.1159/000443124 SN - 1421-9778 (Online) SN - 1015-8987 (Print) VL - 38 IS - 3 SP - 1182 EP - 1198 PB - Karger CY - Basel ER - TY - PAT A1 - Graf, Günter A1 - Groß, Heinz A1 - Sponagel, Stefan T1 - Verfahren zur Herstellung eines Dichtringes mit einer Dichtlippe : Patentschrift DE3621241C1 ; Veröffentlichungstag der Patenterteilung : 25.06.1987 Y1 - 1987 N1 - Volltext über Datenbank DEPATISnet PB - Deutsches Patent- und Markenamt CY - München ER - TY - BOOK A1 - Graf, Günter A1 - Groß, Heinz A1 - Sponagel, Stefan T1 - Verfahren zur Herstellung eines Dichtringes : Europäische Patentschrift EP0250642B1 ; Veröffentlichungstag der Patentschrift: 11.02.1988 Y1 - 1988 N1 - Volltext über Datenbank DEPATISnet PB - Europäisches Patentamt CY - [München u.a.] ER - TY - JOUR A1 - Grajewski, Matthias A1 - Hron, Jaroslav A1 - Turek, Stefan T1 - Numerical analysis for a new non-conforming linear finite element on quadrilaterals JF - Journal of Computational and Applied Mathematics Y1 - 2006 U6 - http://dx.doi.org/10.1016/j.cam.2005.05.024 SN - 0377-0427 VL - 193 IS - 1 SP - 38 EP - 50 ER - TY - JOUR A1 - Grajewski, Matthias A1 - Hron, Jaroslav A1 - Turek, Stefan T1 - Dual weighted a posteriori error estimation for a new nonconforming linear finite element on quadrilaterals JF - Applied Numerical Mathematics N2 - After a short introduction of a new nonconforming linear finite element on quadrilaterals recently developed by Park, we derive a dual weighted residual-based a posteriori error estimator (in the sense of Becker and Rannacher) for this finite element. By computing a corresponding dual solution we estimate the error with respect to a given target error functional. The reliability and efficiency of this estimator is analyzed in several numerical experiments. Y1 - 2005 U6 - http://dx.doi.org/10.1016/j.apnum.2004.09.016 SN - 0168-9274 VL - 54 IS - 3-4 SP - 504 EP - 518 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Kleefeld, Andreas T1 - Detecting and approximating decision boundaries in low-dimensional spaces JF - Numerical Algorithms N2 - A method for detecting and approximating fault lines or surfaces, respectively, or decision curves in two and three dimensions with guaranteed accuracy is presented. Reformulated as a classification problem, our method starts from a set of scattered points along with the corresponding classification algorithm to construct a representation of a decision curve by points with prescribed maximal distance to the true decision curve. Hereby, our algorithm ensures that the representing point set covers the decision curve in its entire extent and features local refinement based on the geometric properties of the decision curve. We demonstrate applications of our method to problems related to the detection of faults, to multi-criteria decision aid and, in combination with Kirsch’s factorization method, to solving an inverse acoustic scattering problem. In all applications we considered in this work, our method requires significantly less pointwise classifications than previously employed algorithms. KW - MCDA KW - Inverse scattering problem KW - Fault approximation KW - Fault detection Y1 - 2023 SN - 1572-9265 N1 - Corresponding author: Matthias Grajewski VL - 93 IS - 4 PB - Springer Science+Business Media CY - Dordrecht ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefam T1 - Numerical analysis and implementational aspects of a new multilevel grid deformation method JF - Applied Numerical Mathematics N2 - Recently, we introduced and mathematically analysed a new method for grid deformation (Grajewski et al., 2009) [15] we call basic deformation method (BDM) here. It generalises the method proposed by Liao et al. (Bochev et al., 1996; Cai et al., 2004; Liao and Anderson, 1992) [4], [6], [20]. In this article, we employ the BDM as core of a new multilevel deformation method (MDM) which leads to vast improvements regarding robustness, accuracy and speed. We achieve this by splitting up the deformation process in a sequence of easier subproblems and by exploiting grid hierarchy. Being of optimal asymptotic complexity, we experience speed-ups up to a factor of 15 in our test cases compared to the BDM. This gives our MDM the potential for tackling large grids and time-dependent problems, where possibly the grid must be dynamically deformed once per time step according to the user's needs. Moreover, we elaborate on implementational aspects, in particular efficient grid searching, which is a key ingredient of the BDM. Y1 - 2010 U6 - http://dx.doi.org/10.1016/j.apnum.2010.03.017 SN - 0168-9274 VL - 60 IS - 8 SP - 767 EP - 781 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Grajewski, Matthias A1 - Köster, Michael A1 - Turek, Stefan T1 - Mathematical and Numerical Analysis of a Robust and Efficient Grid Deformation Method in the Finite Element Context JF - SIAM Journal on Scientific Computing Y1 - 2009 U6 - http://dx.doi.org/10.1137/050639387 VL - 31 IS - 2 SP - 1539 EP - 1557 PB - Society for Industrial and Applied Mathematics CY - Philadelphia, Pa. ER - TY - INPR A1 - Grieger, Niklas A1 - Mehrkanoon, Siamak A1 - Bialonski, Stephan T1 - Preprint: Data-efficient sleep staging with synthetic time series pretraining T2 - arXiv N2 - Analyzing electroencephalographic (EEG) time series can be challenging, especially with deep neural networks, due to the large variability among human subjects and often small datasets. To address these challenges, various strategies, such as self-supervised learning, have been suggested, but they typically rely on extensive empirical datasets. Inspired by recent advances in computer vision, we propose a pretraining task termed "frequency pretraining" to pretrain a neural network for sleep staging by predicting the frequency content of randomly generated synthetic time series. Our experiments demonstrate that our method surpasses fully supervised learning in scenarios with limited data and few subjects, and matches its performance in regimes with many subjects. Furthermore, our results underline the relevance of frequency information for sleep stage scoring, while also demonstrating that deep neural networks utilize information beyond frequencies to enhance sleep staging performance, which is consistent with previous research. We anticipate that our approach will be advantageous across a broad spectrum of applications where EEG data is limited or derived from a small number of subjects, including the domain of brain-computer interfaces. Y1 - 2024 ER - TY - JOUR A1 - Grieger, Niklas A1 - Schwabedal, Justus T. C. A1 - Wendel, Stefanie A1 - Ritze, Yvonne A1 - Bialonski, Stephan T1 - Automated scoring of pre-REM sleep in mice with deep learning JF - Scientific Reports N2 - Reliable automation of the labor-intensive manual task of scoring animal sleep can facilitate the analysis of long-term sleep studies. In recent years, deep-learning-based systems, which learn optimal features from the data, increased scoring accuracies for the classical sleep stages of Wake, REM, and Non-REM. Meanwhile, it has been recognized that the statistics of transitional stages such as pre-REM, found between Non-REM and REM, may hold additional insight into the physiology of sleep and are now under vivid investigation. We propose a classification system based on a simple neural network architecture that scores the classical stages as well as pre-REM sleep in mice. When restricted to the classical stages, the optimized network showed state-of-the-art classification performance with an out-of-sample F1 score of 0.95 in male C57BL/6J mice. When unrestricted, the network showed lower F1 scores on pre-REM (0.5) compared to the classical stages. The result is comparable to previous attempts to score transitional stages in other species such as transition sleep in rats or N1 sleep in humans. Nevertheless, we observed that the sequence of predictions including pre-REM typically transitioned from Non-REM to REM reflecting sleep dynamics observed by human scorers. Our findings provide further evidence for the difficulty of scoring transitional sleep stages, likely because such stages of sleep are under-represented in typical data sets or show large inter-scorer variability. We further provide our source code and an online platform to run predictions with our trained network. Y1 - 2021 U6 - http://dx.doi.org/10.1038/s41598-021-91286-0 SN - 2045-2322 N1 - Corresponding author: Stephan Bialonski VL - 11 IS - Art. 12245 PB - Springer Nature CY - London ER - TY - JOUR A1 - Grießmeier, M. A1 - Sonnenberg, F. A1 - Weckesser, M. A1 - Ziemons, Karl A1 - Langen, K.-J. A1 - Müller-Gärtner, H. W. T1 - Improvement of SPECT quantification in small brain structures by using experiment based recovery-coefficient corrections JF - European Journal of Nuclear Medicine Y1 - 1996 SN - 1619-7089 N1 - Abstracts ; PSu827 VL - 23 IS - 9 SP - 1238 EP - 1238 ER - TY - JOUR A1 - Grinsven, B. van A1 - Bon, N. vanden A1 - Grieten, L. A1 - Murib, M. A1 - Janssen, S. D. A1 - Haenen, K. A1 - Schneider, E. A1 - Ingebrandt, E. A1 - Schöning, Michael Josef A1 - Vermeeren, V. A1 - Ameloot, M. A1 - Michiels, L. A1 - Thoelen, R. A1 - Ceuninck, W. de A1 - Wagner, P. T1 - Rapid assessment of the stability of DNA duplexes by impedimetric real-time monitoring of chemically induced denaturation JF - Lab on a Chip Y1 - 2011 SN - 1473-0197 VL - 11 IS - 9 SP - 1656 EP - 1663 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - JOUR A1 - Grinsven, Bart van A1 - Bon, Natalie vanden A1 - Strauven, Hannelore A1 - Grieten, Lars A1 - Murib, Mohammed A1 - Jiménez Monroy, Kathia L. A1 - Janssens, Stoffel D. A1 - Haenen, Ken A1 - Schöning, Michael Josef A1 - Vermeeren, Veronique A1 - Ameloot, Marcel A1 - Michiels, Luc A1 - Thoelen, Ronald A1 - Ceuninck, Ward de A1 - Wagner, Patrick T1 - Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA. JF - ACS Nano N2 - In this article, we report on the heat-transfer resistance at interfaces as a novel, denaturation-based method to detect single-nucleotide polymorphisms in DNA. We observed that a molecular brush of double-stranded DNA grafted onto synthetic diamond surfaces does not notably affect the heat-transfer resistance at the solid-to-liquid interface. In contrast to this, molecular brushes of single-stranded DNA cause, surprisingly, a substantially higher heat-transfer resistance and behave like a thermally insulating layer. This effect can be utilized to identify ds-DNA melting temperatures via the switching from low- to high heat-transfer resistance. The melting temperatures identified with this method for different DNA duplexes (29 base pairs without and with built-in mutations) correlate nicely with data calculated by modeling. The method is fast, label-free (without the need for fluorescent or radioactive markers), allows for repetitive measurements, and can also be extended toward array formats. Reference measurements by confocal fluorescence microscopy and impedance spectroscopy confirm that the switching of heat-transfer resistance upon denaturation is indeed related to the thermal on-chip denaturation of DNA. Y1 - 2012 U6 - http://dx.doi.org/10.1021/nn300147e SN - 1936-086X VL - 6 IS - 3 SP - 2712 EP - 2721 PB - ACS Publications CY - Washington, DC ER - TY - CHAP A1 - Groebel, Simone A1 - Werner, Frederik A1 - Jörres, Niklas A1 - Jansen, F. A1 - Kasper, Katharina A1 - Schiffels, Johannes A1 - Sprenger, B. A1 - Baumann, Marcus A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Entwicklung einer Sensor-Überwachung für Biogasanlagen auf Basis von Prozessdaten einer Parallelanlage T2 - 10. Dresdner Sensor-Symposium : Dresden, 5. - 7. Dezember 2011 ; miniaturisierte analytische Verfahren, Hochtemperatur-Sensoren, Sensoren für Bioprozess- und Verfahrenstechnik, Sensoren für die Medizin, Chemische Verfahrenstechnik, Lebensmittelanalytik, innovative Sensorlösungen, Sensoren für die Wasserqualität, Selbstüberwachung / Gerald Gerlach ... (Hg.) N2 - Beim Ausbau nachhaltiger, regenerativer Energieversorgung hat die Umwandlung von organischer Biomasse in Biogas ein großes Potential. Der zugrundeliegende, komplexe biologische Prozess wird noch immer unzureichend verstanden und bedarf systematischer Untersuchungen der Prozessparameter, um einen hohen Ertrag bei guter Gasqualität zu ermöglichen. Die Fragestellungen zur Entschlüsselung des Prozesses sind sowohl verfahrenstechnischer als auch mikrobiologischer Natur. Aus mikrobiologischer Sicht ist die Kenntnis der tatsächlich beteiligten prozesstragenden Mikroorganismen von erheblicher Bedeutung, aus verfahrenstechnischer Sicht die Kenntnis der physikalischen und chemischen Faktoren, welche die mikrobiologischen Prozesse und kontrollieren. Im Zusammenspiel aller dieser Parameter wird die Biogasbildung befördert oder behindert, bis zum Abbruch des Prozesses. Eine mögliche Kontrollmethode ist die Messung der metabolischen Aktivität prozesstragender Organismen. Diese soll, beruhend auf fundierten Prozessdaten, gewonnen durch eine Parallelanlage, mit einem lichtadressierbaren potentiometrischen Sensor-System (LAPS) realisiert werden. Dieser Sensor ist in der Lage, pH-Wert-änderungen zu detektieren, die durch den Stoffwechsel der auf dem Chip immobilisierten Organismen hervorgerufen werden, um eine Online-Überwachung von Biogasanlagen zu ermöglichen. Y1 - 2011 SN - 978-3-942710-53-4 U6 - http://dx.doi.org/10.5162/10dss2011/4.3 N1 - Dresdner Beiträge zur Sensorik 43 ; Dresdner Sensor-Symposium ; 10 ; 2011 ; Dresden ; Forschungsgesellschaft für Messtechnik, Sensorik und Medizintechnik ; Zehntes Dresdner Sensor-Symposium ; Dresdner Sensor-Symposium ; (10 ; 2011.12.05-07 ; Dresden) SP - 81 EP - 84 PB - TUDpress CY - Dresden ER - TY - JOUR A1 - Grotendorst, Johannes T1 - On calculating the rate of linear convergence of non-linear transformed sequences JF - Proceeding SNC '11 Proceedings of the 2011 International Workshop on Symbolic-Numeric Computation Y1 - 2011 SN - 978-1-4503-0515-0 SP - 24 EP - 33 PB - ACM CY - New York, NY ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Computational Nanoscience: Do it yourself! : winter school, 14 - 22 February 2006, Forschungszentrum Jülich, Germany ; lecture notes / Grotendorst, Johannes Y1 - 2006 SN - 3-00-017350-1 N1 - NIC series ; 31 ; Forschungszentrum / John-von-Neumann-Institut für Computing PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - GALA - Grünenthal Applied Life Science Analysis : Bericht ; [Projektdokumentation] / John von Neumann-Institut für Computing (NIC); Zentralinstitut für Angewandte Mathematik. Achim Kless und Johannes Grotendorst (Hrsg.) Y1 - 2006 SN - 3-00-017349-8 N1 - NIC-Serie ; 30 ; John von Neumann-Institut für Computing PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - High performance computing in chemistry : report of the joint research project: High Performance Computing in Chemistry - HPC-Chem ; funded by the Federal Ministry for Education and Research (BMBF) ; period: 1 March 2001 - 29 February 2004 / ed. by Johannes Grotendorst Y1 - 2004 SN - 3-00-013618-5 N1 - NIC-Serie ; 25 ; John von Neumann Institute for Computing PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - ComputerMathematik mit Maple Y1 - 2003 SN - 3-89336-325-4 PB - Forschungszentrum Jülich CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - ComputerMathematik mit Maple / 2. Aufl. Y1 - 2003 SN - 3-89336-354-8 N1 - Schriften des Forschungszentrums Jülich : Reihe Informationstechnik ; 5 PB - Forschungszentrum Jülich CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Quantum simulations of complex many body systems/<1> Y1 - 2002 SN - 3-00-009057-6 N1 - NIC series ; 10 ; John-von-Neumann-Institut für Computing PB - Forschungszentrum Jülich CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Quantum simulations of complex many-body systems: from theory to algorithms : winter school, 25 February - 1 March 2002, Rolduc Conference Centre, Kerkrade, the Netherlands ; poster presentations / ed. by Johannes Grotendorst Y1 - 2002 SN - 3-00-009058-4 N1 - NIC series ; 11 ; Winter school ; (2002.02.25-03.01 : ; Kerkrade) PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Quantum Simulations of Complex Many-Body Systems: From Theory to Algorithms, Audio-Visual Lecture Notes / Grotendorst, Johannes [Ed.] Y1 - 2002 SN - 3-00-010000-8 N1 - NIC series ; 14 PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Workshop on Molecular Dynamics on Parallel Computers John von Neumann Institute for Computing (NIC), Research Centre Jülich, Germany 8 - 10 February 1999 Y1 - 2000 SN - 981-02-4232-8 N1 - Workshop on Molecular Dynamics on Parallel Computers <1999, Jülich> ; John-von-Neumann-Institut für Computing PB - World Scientific CY - Singapore ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Modern methods and algorithms of quantum chemistry : winter school, 21 - 25 February 2000, Forschungszentrum Jülich, Germany ; proceedings / organized by John-von-Neumann-Institute for Computing (NIC). Ed. by Johannes Grotendorst ... 2. ed. Y1 - 2000 SN - 3-00-005834-6 N1 - NIC series ; 3 ; Forschungszentrum ; John-von-Neumann-Institut für Computing PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Modern methods and algorithms of quantum chemistry : winter school, 21 - 25 February 2000, Forschungszentrum Jülich, Germany ; proceedings / organized by John-von-Neumann-Institute for Computing (NIC). Ed. by Johannes Grotendorst ... Y1 - 2000 SN - 3-00-005618-1 N1 - NIC series ; 1 ; Forschungszentrum ; John-von-Neumann-Institut für Computing PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Modern methods and algorithms of quantum chemistry : winter school, 21 - 25 February 2000, Forschungszentrum Jülich, Germany ; Poster Presentations / organized by John-von-Neumann-Institute for Computing (NIC). Ed. by Johannes Grotendorst ... Y1 - 2000 SN - 3-00-005746-3 N1 - NIC series ; 2 ; Forschungszentrum ; John-von-Neumann-Institut für Computing PB - NIC CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Gekoppelte SMP-Systeme im wissenschaftlich-technischen Hochleistungsrechnen - Status und Entwicklungsbedarf : Analyse im Auftrag des BMBF / Federführung: Zentralinstitut für Angewandte Mathematik, Forschungszentrum Jülich GmbH ... Ansprechpartner: F. Hoßfeld Y1 - 1999 N1 - Förderkennzeichen BMBF 01 IR 903. - Engl. Zsfassung u.d.T.: Coupled SMP-systems for scientific high-performance computing. PB - Zentralinstitut für Angewandte Mathematik CY - Jülich ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Multiscale Simulation Methods in Molecular Sciences : Institute for Advanced Simulation (IAS) ; winter school, 2 - 6 March 2009, Forschungszentrum Jülich, Germany ; lecture notes Y1 - 2009 SN - 978-3-9810843-8-2 CY - Jülich ER - TY - JOUR A1 - Grotendorst, Johannes T1 - Maple programs for converting series expansions to rational functions using the Levin transformation automatic generation of FORTRAN functions for numerical applications JF - Computer Physics Communications. 55 (1991), H. 3 Y1 - 1991 SN - 0010-4655 SP - 325 EP - 335 ER - TY - BOOK A1 - Grotendorst, Johannes T1 - Höchstleistungsrechnen in der Chemie / Esser, Rüdiger ; Grotendorst, Johannes ; Lewerenz, Marius [Eds.] Y1 - 1998 N1 - Tagung für industrielle Anwender vom 16. bis 18.2.1998 im Forschungszentrum Jülich ER -