TY - JOUR
A1 - Hillen, Walter
T1 - High pT hadron production in photon-photon collisions . TASSO Collaboration
JF - Physics Letters B. 107 (1982), H. 4
Y1 - 1982
SN - 0370-2693
SP - 290
EP - 296
ER -
TY - JOUR
A1 - Hillen, Walter
T1 - Λ, Image production in e+e- annihilation at 33 GeV centre of mass energy. TASSO Collaboration
JF - Physics Letters B. 105 (1981), H. 4
Y1 - 1981
SN - 0370-2693
SP - 75
EP - 80
ER -
TY - JOUR
A1 - Hillen, Walter
T1 - Evidence for charged primary partons in e+e− → 2 jets. TASSO Collaboration
JF - Physics Letters B. 100 (1981), H. 4
Y1 - 1981
SN - 0370-2693
SP - 357
EP - 363
ER -
TY - JOUR
A1 - Hillen, Walter
T1 - Search for new sequential leptons in e+e- annihilation at petra energies. TASSO Collaboration
JF - Physics Letters B. 99 (1981), H. 2
Y1 - 1981
SN - 0370-2693
SP - 163
EP - 168
ER -
TY - JOUR
A1 - Hillen, Walter
T1 - Evidence for a spin-1 gluon in three-jet events. TASSO Collaboration
JF - Physics Letters B. 97 (1980), H. 3-4
Y1 - 1980
SN - 0370-2693
SP - 453
EP - 458
ER -
TY - JOUR
A1 - Hillen, Walter
T1 - RHO-RHO production by two photon scattering. TASSO Collaboration
JF - Physics Letters B. 97 (1980), H. 3-4
Y1 - 1980
SN - 0370-2693
SP - 448
EP - 452
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Alper Selver, M.
A1 - Fischer, Felix
A1 - Kuntalp, Mehmet
T1 - A software tool for interactive generation, representation, and systematical storage of transfer functions for 3D medical images / Alper Selver, M. ; Fischer, Felix ; Kuntalp, Mehmet ; Hillen, Walter
JF - Computer Methods and Programs in Biomedicine. 86 (2007), H. 3
Y1 - 2007
SN - 0169-2607
SP - 270
EP - 280
PB - -
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Barry, J. C.
A1 - Pongs, U. M.
T1 - Algorithm for Purkinje Image I and IV and Limbus Centre Location. Barry, J. C.; Pongs, U. M.; Hillen, W.
JF - Computers in Biology and Medicine. 27 (1997), H. 6
Y1 - 1997
SN - 0010-4825
SP - 515
EP - 531
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Eckenbach, W.
A1 - Quadflieg, Peter
A1 - Zaengel, Thomas T.
T1 - Signal-to-noise performance of a CsI fluorescent screen
JF - Medical Imaging V: Image physics
Y1 - 1991
SN - 0-8194-0538-8
N1 - Proceedings of SPIE ; 1443
SP - 120
EP - 131
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Fischer, Felix
T1 - Farbanalyse von gebackenen oder frittierten Nahrungsmitteln und Vorhersage des Acrylamid-Wertes
JF - 10. Workshop Farbbildverarbeitung : Elektronische Ressource : 7.-8. Oktober 2004, Koblenz = 10th Workshop Color Image Processing / Detlev Droege ... Hrsg.
Y1 - 2004
SN - 389959245X
N1 - Workshop Farbbildverarbeitung <10, 2004, Koblenz>
SP - 133
EP - 148
PB - Der Andere Verl.
CY - Tönning [u.a.]
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Fischer, Felix
A1 - Paulus, Dietrich
T1 - 3D Presentation States: Parametrisierung und Speicherung der 3D-Darstellung von segmentierten medizinischen Volumendaten / Fischer, Felix ; Hillen, Walter ; Paulus, Dietrich
JF - Biomedizinische Technik. 52 (2007), H. Ergänzungsband
Y1 - 2007
SN - 0939-4990
N1 - BMT 2007, 41. Jahrestagung der DGBMT - Deutschen Gesellschaft für Biomedizinische Technik im VDE, Aachen, DE, 26.-29. Sep, 2007
SP - 1
EP - 2
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Jansen, N.
A1 - Unglauben, F.
A1 - Indefrey, R.
T1 - Multimediale Darstellung und Verarbeitung medizinischer Bilddaten in Rechnernetzen.
JF - Bildverarbeitung für die Medizin 1998 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops am 26. und 27. März 1998 in Aachen / Thomas Lehmann ... (Hrsg.)
Y1 - 1998
SN - 3540638857
N1 - Workshop Bildverarbeitung für die Medizin ; <1998, Aachen> Inhaltsverzeichnis
SP - 373
EP - 377
PB - Springer
CY - Berlin [u.a.]
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Lehmann, T.
A1 - Horn, H.
A1 - Schmitt, W.
T1 - IDEFIX - Identifizierung dentaler Fixturen mit morphologischen Filtern. Lehmann, T.; Horn, H.; Schmitt, W., Hillen, W.; Spitzer, K.
JF - Bildverarbeitung für die Medizin : Algorithmen - Systeme - Anwendungen ; proceedings des Aachener Workshops am 8. und 9. November 1996 / Institut für Medizinische Informatik und Biometrie der RWTH Aachen. Hrsg. von Thomas Lehmann ...
Y1 - 1996
SN - 3-86073-519-5
SP - 327
EP - 332
PB - Verl. der Augustinus-Buchh.
CY - Aachen
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Lehmann, T.
A1 - Horn, H.
A1 - Schmitt, W.
T1 - Identification of Dental Fixtures in Intraoral X-rays. Lehmann, T.; Hillen, W.; Horn, H.; Schmitt, W.
JF - Medical imaging 1996 : image processing ; 12 - 15 February 1996, Newport Beach, California / Murray H. Loew ... chairs/ed.
Y1 - 1996
SN - 0-8194-2085-9
N1 - Proceedings of SPIE; 2710
SP - 584
EP - 584
PB - SPIE - The International Society for Optical Engineering
CY - Bellingham, Wash.
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Lehmann, T.
A1 - Horn, H.
A1 - Schmitt, W.
T1 - IDEFIX - Identification of Dental Fixtures. Lehmann, T.; Hillen, W.; Horn, H.; Schmitt, W.
JF - 5th European Congress on Dental and Maxillo-Facial Radiology : 30th Annual meeting of Working Group for Dental Radiology in the German Scientific Society for Dentistry, November 8-11, 1995, Cologne : abstracts
Y1 - 1995
N1 - European Congress on Dental and Maxillo-Facial Radiology <5, 1995, Köln>
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Rupp, S.
A1 - Schiebel, U.
A1 - Zaengel, Thomas T.
T1 - Imaging performance of a selenium-based detector for high-resolution radiography
JF - Medical Imaging III: Image Formation
Y1 - 1989
SN - 0-8194-0125-0
N1 - Proceedings of SPIE ; 1090
SP - 296
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Schiebel, U.
A1 - Zaengel, T.
T1 - A selenium-based detector for digital slot-radiography
JF - Medical Imaging II
Y1 - 1988
N1 - Proceedings of SPIE ; 914
SP - 253
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Schiebel, U.
A1 - Zaengel, T.
T1 - Image quality in selenium-based digital radiography. Schiebel, U.; Hillen, W.; Zaengel, T.
JF - Medical Imaging
Y1 - 1986
N1 - Proceedings of SPIE ; 626
SP - 176
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Schiebel, U.
A1 - Zaengel, T.
T1 - Imaging performance of a digital storage phosphor system
JF - Medical Physics. 14 (1987), H. 5
Y1 - 1987
SN - 0094-2405
SP - 744
EP - 751
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Schmitt, W.
A1 - Bockemühl, J.
T1 - Signal-to-Noise Performance of a digital dental X-ray Detector
JF - Computer assisted radiology : proceedings of the International Symposium on Computer and Communication Systems for Image Guided Diagnosis and Therapy / CAR '95 Berlin, June 21 - 24, 1995. Ed. by H. U. Lemke
Y1 - 1995
SN - 3-540-59177-X
N1 - CAR <6, 1995, Berlin>
PB - Springer
CY - Berlin [u.a.]
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Unglauben, F.
A1 - Indefrey, F.
T1 - Java Image Viewer zur Darstellung und Verarbeitung medizinischer Bilddaten in Rechnernetzen
JF - Intelligente, innovative Produktentwicklung für die industrielle Praxis. Stenzel, Horst [Hrsg.]
Y1 - 2001
N1 - Forschungsverbund Multimedia an Fachhochschulen in Nordrhein-Westfalen
SP - 23
EP - 28
PB - Forschungverbund Multimedia an Fachhochschulen
CY - Köln
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Unglauben, F.
A1 - Kondring, T.
T1 - Java DICOM Viewer für die Teleradiologie. Unglauben, F.; Hillen, W.; Kondring, T.
JF - Bildverarbeitung für die Medizin 2001 : Algorithmen, Systeme, Anwendungen ; proceedings des Workshops [Bildverarbeitung für die Medizin] vom 4. - 6. März 2001 in Lübeck / Heinz Handels ... [Hrsg.]
Y1 - 2001
SN - 3-540-41690-0
N1 - Inhaltsverzeichnis; Workshop Bildverarbeitung für die Medizin <2001, Lübeck>
SP - 404
EP - 408
PB - Springer
CY - Berlin [u.a.]
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Unglauben, F.
A1 - Murdfield, M.
T1 - Study of Database Connections for a Java Medical Image Viewer. Unglauben, F.; Hillen, W.; Murdfield, M.
JF - Intelligente, innovative Produktentwicklung für die industrielle Praxis. Blümel, Bernd; Stenzel, Horst [Hrsg.]
Y1 - 2001
N1 - Forschungsverbund Multimedia an Fachhochschulen in Nordrhein-Westfalen
SP - 29
EP - 33
PB - Forschungverbund Multimedia an Fachhochschulen
CY - Köln
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Unglauben, F.
A1 - Murdfield, M.
T1 - Evaluation of two- and three-tier database connections for a java-based medical image viewer. Unglauben, F.; Hillen, W.; Murdfield, M.
JF - Bildverarbeitung für die Medizin 2000 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops [Bildverarbeitung für die Medizin] vom 12. - 14. März 2000 in München / Alexander Horsch ... [Hrsg.]
Y1 - 2000
SN - 3-540-67123-4
N1 - Inhaltsverzeichnis; Workshop Bildverarbeitung für die Medizin <2000, München>
SP - 203
EP - 207
PB - Springer
CY - Berlin [u.a.]
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Unglauben, F.
A1 - Wirtz, G.
T1 - Architectures and Modeling of Distributed Image Information Systems. Unglauben, F.; Hillen, W.; Wirtz, G.
JF - Proceedings : July 14 - 18, 2002, Orlando, Florida, USA ; [jointly with the 8th International Conference on Information Systems Analysis and Synthesis (ISAS 2002)] / organized by IIIS, International Institute of Informatics and Systemics. Ed. by Nagib Callaos
Y1 - 2002
SN - 9800781501
N1 - World Multiconference on Systemics, Cybernetics and Informatics ; (6, 2002, Orlando, Fla.) ; International Conference on Information Systems, Analysis and Synthesis ; (8, 2002, Orlando, Fla.) ; International Institute of Informatics and Systemics ; World Multiconference on Systemics, Cybernetics and Informatics ; (6 : ; 2002.07.14-18 : ; Orlando, Fla.) ; SCI 2002 ; (6 : ; 2002.07.14-18 : ; Orlando, Fla.) ; International Conference on Information Systems Analysis and Synthesis ; (8 : ; 2002.07.14-18 : ; Orlando, Fla.) ; ISAS 2002 ; (8 : ; 2002.07.14-18 : ; Orlando, Fla.)
PB - IIIS
CY - Orlando, Fla.
ER -
TY - JOUR
A1 - Hillen, Walter
A1 - Winterschlade, T.
A1 - Krone, J.
T1 - Erkennung lokaler Bildfehler in Röntgenbildverstärkern durch parallel arbeitende Bildrechner
JF - Parallele Datenverarbeitung : Entwurfsmethoden, Bildverarbeitung, Simulation ; Workshop der Arbeitsgemeinschaft "Parallelverarbeitung an Fachhochschulen in NRW" am 19.6.1998 in Bochum / Jörg Krone ... (Hrsg.)
Y1 - 1998
SN - 3-18-355310-4
N1 - Fortschritt-Berichte VDI : Reihe 10, Informatik, Kommunikationstechnik ; 553
SP - 88
EP - 94
PB - VDI-Verl.
CY - Düsseldorf
ER -
TY - CHAP
A1 - Hingley, Peter
A1 - Dikta, Gerhard
T1 - Finding a well performing box-jenkins forecasting model for annualised patent filings counts
T2 - International Symposium on Forecasting, Thessaloniki, Greece, June 2019
Y1 - 2019
ER -
TY - JOUR
A1 - Hirschfeld, Julian A.
A1 - Lustfeld, Hans
A1 - Reißel, Martin
A1 - Steffen, Bernhard
T1 - A novel scheme for precise diagnostics and effective stabilization of currents in a fuel cell stack
JF - International Journal of Energy Research
N2 - A novel scheme for detecting inhomogeneous internal currents in a fuel cell stack is presented. In this paper the scheme is investigated for the case that the flow field plates consist of graphite. Then plates of high conductivity, e.g. aluminium between the flow field plates together with small slits in these plates have three effects: (a) Whenever a local inhomogeneity of the electric current occurs at a particular cell in the stack, this will induce a surface current close to that cell perpendicular to the averaged current. This current can be detected. (b) The plates of high conductivity completely prevent the inhomogeneities from spreading to neighbouring cells. (c) Even at the particular cell the inhomogeneity is suppressed as far as possible. Thus this scheme leads to much better diagnostic possibilities and at the same time reduces electric instabilities to an extent, where they probably become harmless. This scheme will first be explained for a simple model to clarify the idea. However, very precise three dimensional computations using realistic parameters are presented, corroborating the results of the simple model.
Y1 - 2010
U6 - https://doi.org/10.1002/er.1662
SN - 0363-907X
VL - 34
IS - 3
SP - 293
EP - 301
PB - Wiley
CY - London
ER -
TY - JOUR
A1 - Hirschfeld, Julian A.
A1 - Lustfeld, Hans
A1 - Reißel, Martin
A1 - Steffen, Bernhard
T1 - Tomographic diagnostics of current distributions in a fuel cell stack
JF - International Journal of Energy Research
N2 - A novel tomographic scheme for analysing the state of any single membrane electrode assembly (MEA) in a stack is suggested. Plates of very high conductivity placed between every fuel cell and slitted in an appropriate manner cause surface currents at well-defined locations of the stack. We show that knowing these surface currents, information about anomalies of the currents in a MEA can be obtained using the methods of tomography. The results are mathematically not unique. However, when assuming plausible defect structures, one can exclude improbable deficiencies by applying a special form of simulated annealing. We present numerical calculations of typical examples demonstrating that the essential defects of the MEA in any single cell of the stack can be detected and their extent can be determined.
Y1 - 2010
U6 - https://doi.org/10.1002/er.1634
SN - 0363-907X
VL - 34
IS - 3
SP - 284
EP - 292
PB - Wiley
CY - London
ER -
TY - PAT
A1 - Hofbauer, Peter
A1 - Härtel, Günter
A1 - Lösing, Karl-Heinrich
A1 - Dorner, Robert
A1 - Simonis, Rainer
A1 - Schulte, Erasmus
T1 - Brennstoffeinspritzsystem für Brennkraftmaschinen : Offenlegungsschrift DE 3833215 A1 ; Offenlegungstag: 28.12.89
N2 - Es wird ein Brennstoffeinspritzsystem für Brennkraftmaschinen vorgeschlagen, bei dem ein definiertes Teil eines fest vorgegebenen Brennstoffvolumens durch die Druckerhöhung innerhalb einer brennstoffeinschließenden Kammer eine definierte Brennstoffmenge über jeweils ein Rückschlagventil abgespritzt wird. Ein elektronisches Steuergerät berechnet die Dauer und/oder Intensität und gegebenenfalls die Impulsfolge eines zum Beispiel zur Verdampfung einer bestimmten Brennstoffmenge erforderlichen Laserimpulses. Das System kann für Ein- oder Mehrstelleinspritzung Verwendung finden.
KW - Brennkraftmaschine
KW - Brennstoffeinspritzsystem
Y1 - 1989
PB - Deutsches Patent- und Markenamt
CY - München
ER -
TY - JOUR
A1 - Honarvarfard, Elham
A1 - Gamella, Maria
A1 - Channaveerappa, Devika
A1 - Darie, Costel C.
A1 - Poghossian, Arshak
A1 - Schöning, Michael Josef
A1 - Katz, Evgeny
T1 - Electrochemically Stimulated Insulin Release from a Modified Graphene–functionalized Carbon Fiber Electrode
JF - Electroanalysis
N2 - A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9–10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of −1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.
Y1 - 2017
U6 - https://doi.org/10.1002/elan.201700095
SN - 1521-4109
VL - 29
IS - 6
SP - 1543
EP - 1553
PB - Wiley-VCH
CY - Weinheim
ER -
TY - JOUR
A1 - Honarvarfard, Elham
A1 - Gamella, Maria
A1 - Poghossian, Arshak
A1 - Schöning, Michael Josef
A1 - Katz, Evgeny
T1 - An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer
JF - Applied Materials Today
N2 - An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte–insulator–semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
KW - Electrolyte–insulator–semiconductor
KW - Capacitive field-effect
KW - CNOT
KW - XOR
KW - Enzyme logic gate
Y1 - 2017
U6 - https://doi.org/10.1016/j.apmt.2017.08.003
SN - 2352-9407
VL - 9
SP - 266
EP - 270
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Horbach, Andreas
A1 - Duong, Minh Tuan
A1 - Staat, Manfred
T1 - Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement
JF - Journal of the mechanical behavior of biomedical materials
Y1 - 2017
U6 - https://doi.org/10.1016/j.jmbbm.2017.06.012
SN - 1751-6161
VL - 74
SP - 400
EP - 410
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Horbach, Andreas
A1 - Staat, Manfred
T1 - Optical strain measurement for the modeling of surgical meshes and their porosity
JF - Current Directions in Biomedical Engineering
N2 - The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.
Y1 - 2018
U6 - https://doi.org/10.1515/cdbme-2018-0045
SN - 2364-5504
VL - Band 4
IS - 1
SP - 181
EP - 184
PB - De Gruyter
CY - Berlin
ER -
TY - JOUR
A1 - Horbach, Andreas
A1 - Staat, Manfred
A1 - Perez-Viana, Daniel
A1 - Simmen, Hans-Peter
A1 - Neuhaus, Valentin
A1 - Pape, Hans-Christoph
A1 - Prescher, Andreas
A1 - Ciritsis, Bernhard
T1 - Biomechanical in vitro examination of a standardized low-volume tubular femoroplasty
JF - Clinical Biomechanics
N2 - Background
Osteoporosis is associated with the risk of fractures near the hip. Age and comorbidities increase the perioperative risk. Due to the ageing population, fracture of the proximal femur also proves to be a socio-economic problem. Preventive surgical measures have hardly been used so far.
Methods
10 pairs of human femora from fresh cadavers were divided into control and low-volume femoroplasty groups and subjected to a Hayes fall-loading fracture test. The results of the respective localization and classification of the fracture site, the Singh index determined by computed tomography (CT) examination and the parameters in terms of fracture force, work to fracture and stiffness were evaluated statistically and with the finite element method. In addition, a finite element parametric study with different position angles and variants of the tubular geometry of the femoroplasty was performed.
Findings
Compared to the control group, the work to fracture could be increased by 33.2%. The fracture force increased by 19.9%. The used technique and instrumentation proved to be standardized and reproducible with an average poly(methyl methacrylate) volume of 10.5 ml. The parametric study showed the best results for the selected angle and geometry.
Interpretation
The cadaver studies demonstrated the biomechanical efficacy of the low-volume tubular femoroplasty. The numerical calculations confirmed the optimal choice of positioning as well as the inner and outer diameter of the tube in this setting. The standardized minimally invasive technique with the instruments developed for it could be used in further comparative studies to confirm the measured biomechanical results.
Y1 - 2020
U6 - https://doi.org/10.1016/j.clinbiomech.2020.105104
VL - 80
IS - Art. 105104
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Horstmann, Marie-Therese
A1 - Bialonski, Stephan
A1 - Noenning, Nina
A1 - Mai, Heinke
A1 - Prusseit, Jens
A1 - Wellmer, Jörg
A1 - Hinrichs, Hermann
A1 - Lehnertz, Klaus
T1 - State dependent properties of epileptic brain networks: Comparative graph–theoretical analyses of simultaneously recorded EEG and MEG
JF - Clinical Neurophysiology
N2 - Objective
To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval.
Methods
We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics.
Results
Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings.
Conclusions
Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks.
Significance
An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks.
Y1 - 2010
U6 - https://doi.org/10.1016/j.clinph.2009.10.013
SN - 1388-2457
VL - 121
IS - 2
SP - 172
EP - 185
PB - Elsevier
CY - Amsterdam
ER -
TY - CHAP
A1 - Huck, Christina
A1 - Bäcker, Matthias
A1 - Poghossian, Arshak
A1 - Wagner, Patrick
A1 - Schöning, Michael Josef
T1 - Bifunktionaler Sensorchip für den Nachweis von Gelöstwasserstoff
Y1 - 2011
SN - 978-3942710-53-4
U6 - https://doi.org/10.5162/10dss2011/16.10
SP - 325
EP - 328
ER -
TY - JOUR
A1 - Huck, Christina
A1 - Jolly, Christina
A1 - Wagner, Patrick
A1 - Poghossian, Arshak
A1 - Schöning, Michael Josef
T1 - One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen
JF - Procedia Engineering. 25 (2011)
Y1 - 2011
SN - 1877-7058
N1 - EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece
SP - 1161
EP - 1164
PB - Elsevier
CY - Amsterdam
ER -
TY - CHAP
A1 - Huck, Christina
A1 - Poghossian, Arshak
A1 - Buniatyan, V.
A1 - Schöning, Michael Josef
T1 - Multi-parameter detection for supporting monitoring and control of biogas processes in agriculture
T2 - Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250)
Y1 - 2014
SN - 978-3-8007-3622-5
SP - 1
EP - 5
PB - VDE-Verl.
CY - Berlin
ER -
TY - JOUR
A1 - Huck, Christina
A1 - Poghossian, Arshak
A1 - Bäcker, Matthias
A1 - Chaudhuri, S.
A1 - Zander, W.
A1 - Schubert, J.
A1 - Begoyan, Vardges K.
A1 - Buniatyan, V. V.
A1 - Wagner, P.
A1 - Schöning, Michael Josef
T1 - Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate
JF - Sensors and actuators. B: Chemical
Y1 - 2014
U6 - https://doi.org/10.1016/j.snb.2014.02.103
SN - 1873-3077 (E-Journal); 0925-4005 (Print)
IS - 198
SP - 102
EP - 109
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Huck, Christina
A1 - Poghossian, Arshak
A1 - Bäcker, Matthias
A1 - Reisert, Steffen
A1 - Kramer, Friederike
A1 - Begoyan, Vardges K.
A1 - Buniatyan, Vahe V.
A1 - Schöning, Michael Josef
T1 - Multi-parameter sensing using high-k oxide of barium strontium titanate
JF - Physica status solidi (a)
N2 - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors. In this work, a Si-based sensor chip containing Pt interdigitated electrodes covered with a thin BST layer (485 nm) has been developed for multi-parameter chemical sensing. The chip has been applied for the contactless measurement of the electrolyte conductivity, the detection of adsorbed charged macromolecules (positively charged polyelectrolytes of polyethylenimine) and the concentration of hydrogen peroxide (H2O2) vapor. The experimental results of functional testing of individual sensors are presented. The mechanism of the BST sensitivity to charged polyelectrolytes and H2O2 vapor has been proposed and discussed.
Y1 - 2015
U6 - https://doi.org/10.1002/pssa.201431911
SN - 1862-6319
VL - 212
IS - 6
SP - 1259
PB - Wiley
CY - Weinheim
ER -
TY - JOUR
A1 - Huck, Christina
A1 - Poghossian, Arshak
A1 - Bäcker, Matthias
A1 - Reisert, Steffen
A1 - Schubert, J.
A1 - Zander, W.
A1 - Begoyan, Vardges K.
A1 - Buniatyan, V. V.
A1 - Schöning, Michael Josef
T1 - Chemical sensors based on a high-k perovskite oxide of barium strontium titanate
JF - Procedia Engineering
N2 - High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor.
KW - barium strontium titanate
KW - high-k material
KW - contactless conductivity sensor
KW - multi-functional material
KW - hydrogen peroxide
Y1 - 2014
U6 - https://doi.org/10.1016/j.proeng.2014.11.258
SN - 1877-7058
N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014>
VL - 87
SP - 28
EP - 31
PB - Elsevier
CY - Amsterdam
ER -
TY - CHAP
A1 - Huck, Christina
A1 - Poghossian, Arshak
A1 - Bäcker, Matthias
A1 - Zander, W.
A1 - Schubert, J.
A1 - Sukoyan, L. H.
A1 - Begoyan, Vardges K.
A1 - Buniatyan, V. V.
A1 - Wagner, Patrick
A1 - Schöning, Michael Josef
T1 - Chemische Sensoren mit Bariumstrontiumtitanat als funktionelle Schicht zur Multiparameterdetektion
T2 - 11. Dresdner Sensor-Symposium : 9.-11.12.2013
Y1 - 2013
SN - 978-3-9813484-5-3
SP - 368
EP - 372
ER -
TY - JOUR
A1 - Huck, Christina
A1 - Poghossian, Arshak
A1 - Kerroumi, Iman
A1 - Schusser, Sebastian
A1 - Bäcker, Matthias
A1 - Zander, Willi
A1 - Schubert, Jürgen
A1 - Buniatyan, Vahe V.
A1 - Martirosyan, Norayr W.
A1 - Wagner, Patrick
A1 - Schöning, Michael Josef
T1 - Multiparameter sensor chip with Barium Strontium Titanate as multipurpose material
JF - Electroanalysis
N2 - It is well known that biochemical and biotechnological processes are strongly dependent and affected by a variety of physico-chemical parameters such as pH value, temperature, pressure and electrolyte conductivity. Therefore, these quantities have to be monitored or controlled in order to guarantee a stable process operation, optimization and high yield. In this work, a sensor chip for the multiparameter detection of three physico-chemical parameters such as electrolyte conductivity, pH and temperature is realized using barium strontium titanate (BST) as multipurpose material. The chip integrates a capacitively coupled four-electrode electrolyte-conductivity sensor, a capacitive field-effect pH sensor and a thin-film Pt-temperature sensor. Due to the multifunctional properties of BST, it is utilized as final outermost coating layer of the processed sensor chip and serves as passivation and protection layer as well as pH-sensitive transducer material at the same time. The results of testing of the individual sensors of the developed multiparameter sensor chip are presented. In addition, a quasi-simultaneous multiparameter characterization of the sensor chip in buffer solutions with different pH value and electrolyte conductivity is performed. To study the sensor behavior and the suitability of BST as multifunctional material under harsh environmental conditions, the sensor chip was exemplarily tested in a biogas digestate.
Y1 - 2014
U6 - https://doi.org/10.1002/elan.201400076
SN - 1521-4109 (E-Journal); 1040-0397 (Print)
VL - 26
IS - 5
SP - 980
EP - 987
PB - Wiley-VCH
CY - Weinheim
ER -
TY - JOUR
A1 - Huck, Christina
A1 - Poghossian, Arshak
A1 - Wagner, Patrick
A1 - Schöning, Michael Josef
T1 - Combined amperometric/field-effect sensor for the detection of dissolved hydrogen
JF - Sensors and actuators B: Chemical
N2 - Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3% (v/v) with a slope of 198.4 ± 13.7 nA/% (v/v) and 14.9 ± 0.5 mV/% (v/v), respectively.
Y1 - 2012
U6 - https://doi.org/10.1016/j.snb.2012.10.050
SN - 0925-4005
N1 - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors"
VL - 187
SP - 168
EP - 173
PB - Elsevier
CY - Amsterdam
ER -
TY - JOUR
A1 - Huck, Christina
A1 - Schiffels, Johannes
A1 - Herrera, Cony N.
A1 - Schelden, Maximilian
A1 - Selmer, Thorsten
A1 - Poghossian, Arshak
A1 - Baumann, Marcus
A1 - Wagner, Patrick
A1 - Schöning, Michael Josef
T1 - Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor
JF - Physica Status Solidi (A)
N2 - Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the “welfare” of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis–Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.
Y1 - 2013
U6 - https://doi.org/10.1002/pssa.201200900
SN - 0031-8965
VL - 210
IS - 5
SP - 926
EP - 931
PB - Wiley-VCH
CY - Weinheim
ER -
TY - JOUR
A1 - Hugenroth, Kristin
A1 - Borchardt, Ralf
A1 - Ritter, Philine
A1 - Groß‑Hardt, Sascha
A1 - Meyns, Bart
A1 - Verbelen, Tom
A1 - Steinseifer, Ulrich
A1 - Kaufmann, Tim A. S.
A1 - Engelmann, Ulrich M.
T1 - Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input
JF - Scientific Reports
N2 - Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.
Y1 - 2021
U6 - https://doi.org/10.1038/s41598-021-96397-2
SN - 2045-2322
VL - 11
IS - Art. No. 16800
SP - 1
EP - 12
PB - Springer
CY - Berlin
ER -
TY - JOUR
A1 - Hugenroth, Kristin
A1 - Neidlin, Michael
A1 - Engelmann, Ulrich M.
A1 - Kaufmann, Tim A. S.
A1 - Steinseifer, Ulrich
A1 - Heilmann, Torsten
T1 - Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk‐Reduced Placement: an In Silico Proof‐of‐Concept
JF - Artificial Organs
Y1 - 2021
U6 - https://doi.org/10.1111/aor.13964
SN - 1525-1594
IS - Accepted Article
PB - Wiley
CY - Weinheim
ER -
TY - CHAP
A1 - Hunker, Jan
A1 - Jung, Alexander
A1 - Goßmann, Matthias
A1 - Linder, Peter
A1 - Staat, Manfred
ED - Staat, Manfred
ED - Erni, Daniel
T1 - Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue
T2 - 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
N2 - The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.
Y1 - 2019
SN - 978-3-940402-22-6
U6 - https://doi.org/10.17185/duepublico/48750
SP - 7
EP - 8
PB - Universität Duisburg-Essen
CY - Duisburg
ER -
TY - JOUR
A1 - Hunker, Jan L.
A1 - Gossmann, Matthias
A1 - Raman, Aravind Hariharan
A1 - Linder, Peter
T1 - Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility
JF - Journal of Pharmacological and Toxicological Methods
Y1 - 2021
U6 - https://doi.org/10.1016/j.vascn.2021.107044
SN - 1056-8719
VL - 111
IS - Article number 107044
PB - Elsevier
CY - New York
ER -