TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Neuendorf, Christian
A1  - Faßbender, Tobias
A1  - Nölke, Greta
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
A1  - Schröper, Florian
T1  - Sensitive and rapid detection of cholera toxin subunit B using magnetic frequency mixing detection
JF  - Plos One
N2  - Cholera is a life-threatening disease caused by the cholera toxin (CT) as produced by some Vibrio cholerae serogroups. In this research we present a method which directly detects the toxin’s B subunit (CTB) in drinking water. For this purpose we performed a magnetic sandwich immunoassay inside a 3D immunofiltration column. We used two different commercially available antibodies to capture CTB and for binding to superparamagnetic beads. ELISA experiments were performed to select the antibody combination. The beads act as labels for the magnetic frequency mixing detection technique. We show that the limit of detection depends on the type of magnetic beads. A nonlinear Hill curve was fitted to the calibration measurements by means of a custom-written python software. We achieved a sensitive and rapid detection of CTB within a broad concentration range from 0.2 ng/ml to more
than 700 ng/ml.
Y1  - 2019
U6  - http://dx.doi.org/10.1371/journal.pone.0219356
SN  - 1932-6203
VL  - 14
IS  - 7
PB  - Plos
CY  - San Francisco
ER  - 
TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Pourshahidi, Ali Mohammad
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
T1  - Multiplex detection of different magnetic beads using frequency scanning in magnetic frequency mixing technique
JF  - Sensors
N2  - In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles’ nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil’s signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements.
KW  - frequency mixing magnetic detection
KW  - magnetic sandwich immunoassay
KW  - multiparametric immunoassays
Y1  - 2019
U6  - http://dx.doi.org/10.3390/s19112599
SN  - 1424-8220
VL  - 19
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Schönenborn, Kristina
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
T1  - Measurement of the magnetophoretic velocity of different superparamagnetic beads
JF  - Journal of Magnetism and Magnetic Materials
N2  - The movement of magnetic beads due to a magnetic field gradient is of great interest in different application fields. In this report we present a technique based on a magnetic tweezers setup to measure the velocity factor of magnetically actuated individual superparamagnetic beads in a fluidic environment. Several beads can be tracked simultaneously in order to gain and improve statistics. Furthermore we show our results for different beads with hydrodynamic diameters between 200 and 1000 nm from diverse manufacturers. These measurement data can, for example, be used to determine design parameters for a magnetic separation system, like maximum flow rate and minimum separation time, or to select suitable beads for fixed experimental requirements.
KW  - magnetophoretic velocity
KW  - superparamagnetic bead
KW  - magnetic tweezers
KW  - magnetic separation
KW  - magnetic actuation
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jmmm.2018.10.066
SN  - 0304-8853
VL  - 477
IS  - 1
SP  - 244
EP  - 248
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Achtsnicht, Stefan
A1  - Tödter, Julia
A1  - Niehues, Julia
A1  - Telöken, Matthias
A1  - Offenhäusser, Andreas
A1  - Krause, Hans-Joachim
A1  - Schröper, Florian
T1  - 3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection
JF  - Sensors
N2  - For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated.
Y1  - 2019
U6  - http://dx.doi.org/10.3390/s19010148
SN  - 1424-8220
VL  - 19
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Albanna, Walid
A1  - Lüke, Jan Niklas
A1  - Schubert, Gerrit Alexander
A1  - Dibué-Adjei, Maxine
A1  - Kotliar, Konstantin
A1  - Hescheler, Jürgen
A1  - Clusmann, Hans
A1  - Steiger, Hans-Jakob
A1  - Hänggi, Daniel
A1  - Kamp, Marcel A.
A1  - Schneider, Toni
A1  - Neumaier, Felix
T1  - Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity
JF  - Molecular and Cellular Neuroscience
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.mcn.2019.03.003
SN  - 1044-7431
VL  - 96
IS  - 4
SP  - 35
EP  - 46
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Toward an immobilization method for spore-based biosensors in oxidative environment
JF  - Electrochimica Acta
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.electacta.2019.01.148
VL  - 302
SP  - 394
EP  - 401
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Arreola, Julio
A1  - Keusgen, Michael
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.111628
SN  - 0956-5663
VL  - 143
IS  - 111628
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Attar, Mandana Hossein Zadeh
A1  - Merk, Hans F.
A1  - Kotliar, Konstantin
A1  - Wurpts, Gerda
A1  - Röseler, Stefani
A1  - Moll-Slodowy, Silke
A1  - Plange, Johann
A1  - Baron, Jens Malte
A1  - Balakirski, Galina
T1  - The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria
JF  - European Journal of Dermatology
Y1  - 2019
U6  - http://dx.doi.org/10.1684/ejd.2019.3680
VL  - 29
IS  - 6
SP  - 614
EP  - 618
ER  - 
TY  - JOUR
A1  - Baringhaus, Ludwig
A1  - Gaigall, Daniel
T1  - On an asymptotic relative efficiency concept based on expected volumes of confidence regions
JF  - Statistics - A Journal of Theoretical and Applied Statistic
N2  - The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.
KW  - Volume of confidence regions
KW  - asymptotic relative efficiency
KW  - likelihood ratio test
KW  - multivariate normal distribution
KW  - multinomial distribution
Y1  - 2019
U6  - http://dx.doi.org/10.1080/02331888.2019.1683560
SN  - 1029-4910
VL  - 53
IS  - 6
SP  - 1396
EP  - 1436
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Bartella, Alexander K.
A1  - Kamal, Mohammad
A1  - Scholl, Ingrid
A1  - Schiffer, Stefan
A1  - Steegmann, Julius
A1  - Ketelsen, Dominik
A1  - Hölzle, Frank W.
A1  - Lethaus, Bernd
T1  - Virtual reality in preoperative imaging in maxillofacial surgery: implementation of “the next level”?
JF  - British Journal of Oral and Maxillofacial Surgery
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bjoms.2019.02.014
SN  - 0266-4356
VL  - 57
IS  - 7
SP  - 644
EP  - 648
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bhattarai, Aroj
A1  - Staat, Manfred
T1  - A computational study of organ relocation after laparoscopic pectopexy to repair posthysterectomy vaginal vault prolapse
JF  - Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization
Y1  - 2019
U6  - http://dx.doi.org/10.1080/21681163.2019.1670095
SN  - 2168-1171
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Bleilevens, Christian
A1  - Hill, Aileen
A1  - Grzanna, Tim
A1  - Fechter, Tamara
A1  - Bohnen, Melanie
A1  - Weber, Hans-Joachim
A1  - Beckers, Christian
A1  - Borosch, Sebastian
A1  - Zayat, Rashad
A1  - Benstoem, Carin
A1  - Rossaint, Rolf
A1  - Goetzenich, Andreas
T1  - In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop
JF  - Interactive cardiovascular and thoracic surgery
Y1  - 2019
U6  - http://dx.doi.org/10.1093/icvts/ivy206
SN  - 1569-9285
VL  - 28
IS  - 1
SP  - 120
EP  - 127
ER  - 
TY  - JOUR
A1  - Breuer, Lars
A1  - Pilas, Johanna
A1  - Guthmann, Eric
A1  - Schöning, Michael Josef
A1  - Thoelen, Ronald
A1  - Wagner, Torsten
T1  - Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels
JF  - Sensor and Actuators B: Chemical
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.snb.2019.02.086
SN  - 0925-4005
VL  - 288
SP  - 579
EP  - 585
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bronder, Thomas
A1  - Poghossian, Arshak
A1  - Jessing, Max P.
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Surface regeneration and reusability of label-free DNA biosensors based on weak polyelectrolyte-modified capacitive field-effect structures
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2018.11.019
SN  - 0956-5663
VL  - 126
SP  - 510
EP  - 517
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bucur, Alexandru
A1  - Lazarescu, Lucian
A1  - Pop, Grigore Marian
A1  - Achimas, Gheorghe
A1  - Gebhardt, Andreas
T1  - Tribological performance of biodegradable lubricants under different surface roughness of tools
JF  - Academic Journal of Manufacturing Engineering
Y1  - 2019
SN  - 1583-7904
VL  - 17
IS  - 1
SP  - 172
EP  - 178
ER  - 
TY  - JOUR
A1  - Butenweg, Christoph
A1  - Marinkovic, Marko
A1  - Salatic, Ratko
T1  - Experimental results of reinforced concrete frames with masonry infills under combined quasi-static in-plane and out-of-plane seismic loading
JF  - Bulletin of Earthquake Engineering
Y1  - 2019
U6  - http://dx.doi.org/10.1007/s10518-019-00602-7
SN  - 1573-1456
VL  - 17
SP  - 3397
EP  - 3422
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Campen, R.
A1  - Kowalski, Julia
A1  - Lyons, W.B.
A1  - Tulaczyk, S.
A1  - Dachwald, Bernd
A1  - Pettit, E.
A1  - Welch, K. A.
A1  - Mikucki, J.A.
T1  - Microbial diversity of an Antarctic subglacial community and high‐resolution replicate sampling inform hydrological connectivity in a polar desert
JF  - Environmental Microbiology
Y1  - 2019
U6  - http://dx.doi.org/10.1111/1462-2920.14607
SN  - 1462-2920
IS  - accepted article
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Capri, Miriam
A1  - Morsiani, Cristina
A1  - Santoro, Aurelia
A1  - Moriggi, Manuela
A1  - Conte, Maria
A1  - Martucci, Morena
A1  - Bellavista, Elena
A1  - Fabbri, Cristina
A1  - Giampieri, Enrico
A1  - Albracht, Kirsten
A1  - Flück, Martin
A1  - Ruoss, Severin
A1  - Brocca, Lorenza
A1  - Canepari, Monica
A1  - Longa, Emanuela
A1  - Giulio, Irene Di
A1  - Bottinelli, Roberto
A1  - Cerretelli, Paolo
A1  - Salvioli, Stefano
A1  - Gelfi, Cecilia
A1  - Franceschi, Claudio
A1  - Narici, Marco
A1  - Rittweger, Jörn
T1  - Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
JF  - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Y1  - 2019
U6  - http://dx.doi.org/10.1096/fj.201801625R
VL  - 33
IS  - 4
SP  - 5168
EP  - 5180
ER  - 
TY  - JOUR
A1  - Claer, Mario
A1  - Ferrein, Alexander
A1  - Schiffer, Stefan
T1  - Calibration of a Rotating or Revolving Platform with a LiDAR Sensor
JF  - Applied Sciences
Y1  - 2019
U6  - http://dx.doi.org/10.3390/app9112238
SN  - 2076-3417
VL  - Volume 9
IS  - issue 11, 2238
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Cornelis, Peter
A1  - Givanoudi, Stella
A1  - Yongabi, Derick
A1  - Iken, Heiko
A1  - Duwé, Sam
A1  - Deschaume, Olivier
A1  - Robbens, Johan
A1  - Dedecker, Peter
A1  - Bartic, Carmen
A1  - Wübbenhorst, Michael
A1  - Schöning, Michael Josef
A1  - Heyndrickx, Marc
A1  - Wagner, Patrick
T1  - Sensitive and specific detection of E. coli using biomimetic receptors in combination with a modified heat-transfer method
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.04.026
SN  - 0956-5663
VL  - 136
SP  - 97
EP  - 105
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Selmer, Thorsten
A1  - Wagner, Torsten
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.111332
VL  - 139
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dantism, Shahriar
A1  - Röhlen, Desiree
A1  - Wagner, Torsten
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - A LAPS-based differential sensor for parallelized metabolism monitoring of various bacteria
JF  - Sensors
N2  - Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process.
Y1  - 2019
U6  - http://dx.doi.org/10.3390/s19214692
SN  - 1424-8220
VL  - 19
IS  - 21
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Delaittre, Guillaume
T1  - Telechelic Poly(2-Oxazoline)s
JF  - European Polymer Journal
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.eurpolymj.2019.109281
SN  - 0014-3057
IS  - In Press, Journal Pre-proof, 109281
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Dotzauer, Martin
A1  - Pfeiffer, Diana
A1  - Lauer, Markus
A1  - Pohl, Marcel
A1  - Mauky, Eric
A1  - Bär, Katharina
A1  - Sonnleitner, Matthias
A1  - Zörner, Wilfried
A1  - Hudde, Jessica
A1  - Schwarz, Björn
A1  - Faßauer, Burkhardt
A1  - Dahmen, Markus
A1  - Rieke, Christian
A1  - Herbert, Johannes
A1  - Thrän, Daniela
T1  - How to measure flexibility – Performance indicators for demand driven power generation from biogas plants
JF  - Renewable Energy
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.renene.2018.10.021
SN  - 0960-1481
SP  - 135
EP  - 146
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engel, Mareike
A1  - Bayer, Hendrik
A1  - Holtmann, Dirk
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Flavin secretion of Clostridium acetobutylicum in a bioelectrochemical system - Is an iron limitation involved?
JF  - Bioelectrochemistry
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bioelechem.2019.05.014
SN  - 1567-5394
IS  - In Press, Accepted Manuscript
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engel, Mareike
A1  - Gemünde, Andre
A1  - Holtmann, Dirk
A1  - Müller-Renno, Christine
A1  - Ziegler, Christiane
A1  - Tippkötter, Nils
A1  - Ulber, Roland
T1  - Clostridium acetobutylicum’s connecting world: cell appendage formation in bioelectrochemical systems
JF  - ChemElectroChem
Y1  - 2019
U6  - http://dx.doi.org/10.1002/celc.201901656
SN  - 2196-0216
IS  - Accepted Article
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Seifert, Julian
A1  - Mues, Benedikt
A1  - Roitsch, Stefan
A1  - Ménager, Christine
A1  - Schmidt, Annette M.
A1  - Slabu, Ioana
T1  - Heating efficiency of magnetic nanoparticles decreases with gradual immobilization in hydrogels
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jmmm.2018.09.113
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 486
EP  - 494
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Engelmann, Ulrich M.
A1  - Shasha, Carolyn
A1  - Teeman, Eric
A1  - Slabu, Iona
A1  - Krishnan, Kannan M.
T1  - Predicting size-dependent heating efficiency of magnetic nanoparticles from experiment and stochastic Néel-Brown Langevin simulation
JF  - Journal of Magnetism and Magnetic Materials
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jmmm.2018.09.041
SN  - 0304-8853
VL  - 471
IS  - 1
SP  - 450
EP  - 456
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Finger, Felix
A1  - Bil, Cees
A1  - Braun, Carsten
T1  - Initial Sizing Methodology for Hybrid-Electric General Aviation Aircraft
JF  - Journal of Aircraft
Y1  - 2019
U6  - http://dx.doi.org/10.2514/1.C035428
SN  - 1533-3868
VL  - 57
IS  - 2
SP  - 245
EP  - 255
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Beckmann, Nils
A1  - Abanteriba, Sylvester
T1  - An overview on dry low NOx micromix combustor development for hydrogen-rich gas turbine applications
JF  - International Journal of Hydrogen Energy
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.ijhydene.2019.01.161
SN  - 0360-3199
VL  - 44
IS  - 13
SP  - 6978
EP  - 6990
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Funke, Harald
A1  - Beckmann, Nils
A1  - Keinz, Jan
A1  - Abanteriba, Sylvester
T1  - Numerical and Experimental Evaluation of a Dual-Fuel Dry-Low-NOx Micromix Combustor for Industrial Gas Turbine Applications
JF  - Journal of Thermal Science and Engineering Applications
Y1  - 2019
U6  - http://dx.doi.org/10.1115/1.4041495
SN  - 19485085
N1  - Paper No: GT2017-64795
VL  - 11
IS  - 1
SP  - 011015
PB  - ASME
CY  - New York
ER  - 
TY  - JOUR
A1  - Gaigall, Daniel
T1  - On a new approach to the multi-sample goodness-of-fit problem
JF  - Communications in Statistics - Simulation and Computation
N2  - Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.
KW  - Goodness-of-fit test
KW  - Multi-sample problem
KW  - Parametric bootstrap
Y1  - 2019
U6  - http://dx.doi.org/10.1080/03610918.2019.1618472
SN  - 1532-4141
VL  - 53
IS  - 10
SP  - 2971
EP  - 2989
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Götten, Falk
A1  - Havermann, Marc
A1  - Braun, Carsten
A1  - Gomez, Francisco
A1  - Bil, Cees
T1  - RANS Simulation Validation of a Small Sensor Turret for UAVs
JF  - Journal of Aerospace Engineering
N2  - Recent Unmanned Aerial Vehicle (UAV) design procedures rely on full aircraft steady-state Reynolds-Averaged-Navier-Stokes (RANS) analyses in early design stages. Small sensor turrets are included in such simulations, even though their aerodynamic properties show highly unsteady behavior. Very little is known about the effects of this approach on the simulation outcomes of small turrets. Therefore, the flow around a model turret at a Reynolds number of 47,400 is simulated with a steady-state RANS approach and compared to experimental data. Lift, drag, and surface pressure show good agreement with the experiment. The RANS model predicts the separation location too far downstream and shows a larger recirculation region aft of the body. Both characteristic arch and horseshoe vortex structures are visualized and qualitatively match the ones found by the experiment. The Reynolds number dependence of the drag coefficient follows the trend of a sphere within a distinct range. The outcomes indicate that a steady-state RANS model of a small sensor turret is able to give results that are useful for UAV engineering purposes but might not be suited for detailed insight into flow properties.
Y1  - 2019
U6  - http://dx.doi.org/10.1061/(ASCE)AS.1943-5525.0001055
SN  - 1943-5525
VL  - 32
IS  - 5
PB  - ASCE
CY  - New York
ER  - 
TY  - JOUR
A1  - Göttsche, Joachim
A1  - Alexopoulos, Spiros
A1  - Dümmler, Andreas
A1  - Maddineni, S. K.
T1  - Multi-Mirror Array Calculations With Optical Error
N2  - The optical performance of a 2-axis solar concentrator was simulated with the COMSOL Multiphysics® software. The concentrator consists of a mirror array, which was created using the application builder. The mirror facets are preconfigured to form a focal point. During tracking all mirrors are moved simultaneously in a coupled mode by 2 motors in two axes, in order to keep the system in focus with the moving sun. Optical errors on each reflecting surface were implemented in combination with the solar angular cone of ± 4.65 mrad. As a result, the intercept factor of solar radiation that is available to the receiver was calculated as a function of the transversal and longitudinal angles of incidence. In addition, the intensity distribution on the receiver plane was calculated as a function of the incidence angles.
KW  - solar process heat
KW  - concentrating collector
KW  - raytracing
KW  - point-focussing system
Y1  - 2019
SP  - 1
EP  - 6
ER  - 
TY  - JOUR
A1  - Hüning, Felix
A1  - Hillgärtner, Michael
A1  - Reke, Michael
T1  - Rolling Labs – Teaching Vehicle Electronics from the Beginning
JF  - International Journal of Engineering Pedagogy (iJEP)
Y1  - 2019
U6  - http://dx.doi.org/10.3991/ijep.v9i1.9241
SN  - 2192-4880
VL  - 9
IS  - 1
SP  - 34
EP  - 49
ER  - 
TY  - JOUR
A1  - Iken, Heiko
A1  - Bronder, Thomas
A1  - Goretzki, Alexander
A1  - Kriesel, Jana
A1  - Ahlborn, Kristina
A1  - Gerlach, Frank
A1  - Vonau, Winfried
A1  - Zander, Willi
A1  - Schubert, Jürgen
A1  - Schöning, Michael Josef
T1  - Development of a Combined pH- and Redox-Sensitive Bi-Electrode Glass Thin-Film Sensor
JF  - physica status solidi a : applications and materials sciences
Y1  - 2019
U6  - http://dx.doi.org/10.1002/pssa.201900114
SN  - 1862-6319
VL  - 216
IS  - 12
SP  - 1
EP  - 8
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Jan Thimo, Grundmann
A1  - Bauer, Waldemar
A1  - Biele, Jens
A1  - Boden, Ralf
A1  - Ceriotti, Matteo
A1  - Cordero, Federico
A1  - Dachwald, Bernd
A1  - Dumont, Etienne
A1  - Grimm, Christian D.
A1  - Hercik, David
T1  - Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs
JF  - Acta Astronautica
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.actaastro.2018.03.019
SN  - 0094-5765
VL  - 156
IS  - 3
SP  - 330
EP  - 362
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jayaraman, Chandrasekaran
A1  - Mummidisetty, Chaitanya Krishna
A1  - Loesch, Alexandra
A1  - Kaur, Sandi
A1  - Hoppe-Ludwig, Shenan
A1  - Staat, Manfred
A1  - Jayaraman, Arun
T1  - Postural and metabolic benefits of using a forearm support walker in older adults with impairments
JF  - Archives of Physical Medicine and Rehabilitation
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.apmr.2018.10.001
SN  - 0003-9993
VL  - Volume 100
IS  - Issue 4
SP  - 638
EP  - 647
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jildeh, Zaid B.
A1  - Kirchner, Patrick
A1  - Baltes, Klaus
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
T1  - Development of an in-line evaporation unit for the production of gas mixtures containing hydrogen peroxide – numerical modeling and experimental results
JF  - International Journal of Heat and Mass Transfer
N2  - Hydrogen peroxide (H2O2) is a typical surface sterilization agent for packaging materials used in the pharmaceutical, food and beverage industries. We use the finite-elements method to analyze the conceptual design of an in-line thermal evaporation unit to produce a heated gas mixture of air and evaporated H2O2 solution. For the numerical model, the required phase-transition variables of pure H2O2  solution and of the aerosol mixture are acquired from vapor-liquid equilibrium (VLE) diagrams derived from vapor-pressure formulations. This work combines homogeneous single-phase turbulent flow with heat-transfer physics to describe the operation of the evaporation unit. We introduce the apparent heat-capacity concept to approximate the non-isothermal phase-transition process of the H2O2-containing aerosol. Empirical and analytical functions are defined to represent the temperature- and pressure-dependent material properties of the aqueous H2O2 solution, the aerosol and the gas mixture. To validate the numerical model, the simulation results are compared to experimental data on the heating power required to produce the gas mixture. This shows good agreement with the deviations below 10%. Experimental observations on the formation of deposits due to the evaporation of stabilized H2O2 solution fits the prediction made from simulation results.
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.118519
SN  - 0017-9310
VL  - 143
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Müller, Wolfram
A1  - Staat, Manfred
T1  - Optimization of the flight technique in ski jumping: the influence of wind
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.jbiomech.2019.03.023
IS  - Early view
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Jung, Alexander
A1  - Staat, Manfred
T1  - Modeling and simulation of human induced pluripotent stem cell-derived cardiac tissue
JF  - GAMM - Mitteilungen der Gesellschaft für Angewandte Mathematik und Mechanik
Y1  - 2019
U6  - http://dx.doi.org/10.1002/gamm.201900002
SN  - 1522-2608
VL  - 42
IS  - 4
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Kapelyukh, Yury
A1  - Henderson, Colin James
A1  - Scheer, Nico
A1  - Rode, Anja
A1  - Wolf, Charles Roland
T1  - Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice
JF  - Drug Metabolism and Disposition
Y1  - 2019
U6  - http://dx.doi.org/10.1124/dmd.119.087718
IS  - Early view
ER  - 
TY  - JOUR
A1  - Karschuck, T. L.
A1  - Filipov, Y.
A1  - Bollella, P.
A1  - Schöning, Michael Josef
A1  - Katz, E.
T1  - Not-XOR (NXOR) logic gate based on an enzyme-catalyzed reaction
JF  - International Journal of Unconventional Computing
N2  - Enzyme-catalyzed reactions have been designed to mimic various Boolean logic gates in the general framework of unconventional biomolecular computing. While some of the logic gates, particularly OR, AND, are easy to realize with biocatalytic reactions and have been reported in numerous publications, some other, like NXOR, are very challenging and have not been realized yet with enzyme reactions. The paper reports on a novel approach to mimicking the NXOR logic gate using the bell-shaped enzyme activity dependent on pH values. Shifting pH from the optimum value to the acidic or basic values by using acid or base inputs (meaning 1,0 and 0,1 inputs) inhibits the enzyme reaction, while keeping the optimum pH (assuming 0,0 and 1,1 input combinations) preserves a high enzyme activity. The challenging part of the present approach is the selection of an enzyme with a well-demonstrated bell-shape activity dependence on the pH value. While many enzymes can satisfy this condition, we selected pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase as this enzyme has the optimum pH center-located on the pH scale allowing the enzyme activity change by the acidic and basic pH shift from the optimum value corresponding to the highest activity. The present NXOR gate is added to the biomolecular “toolbox” as a new example of Boolean logic gates based on enzyme reactions.
Y1  - 2019
SN  - 1548-7199
VL  - 14
IS  - 3-4
SP  - 235
EP  - 242
PB  - Old City Publishing
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Ketelhut, Maike
A1  - Kolditz, Melanie
A1  - Göll, Fabian
A1  - Braunstein, Bjoern
A1  - Albracht, Kirsten
A1  - Abel, Dirk
T1  - Admittance control of an industrial robot during resistance training
JF  - IFAC-PapersOnLine
N2  - Neuromuscular strength training of the leg extensor muscles plays an important role in the rehabilitation and prevention of age and wealth related diseases. In this paper, we focus on the design and implementation of a Cartesian admittance control scheme for isotonic training, i.e. leg extension and flexion against a predefined weight. For preliminary testing and validation of the designed algorithm an experimental research and development platform consisting of an 
industrial robot and a force plate mounted at its end-effector has been used. Linear, diagonal and arbitrary two-dimensional motion trajectories with different weights for the leg extension and flexion part are applied. The proposed algorithm is easily adaptable to trajectories consisting of arbitrary six-dimensional poses and allows the implementation of individualized trajectories.
KW  - Assistive technology
KW  - Rehabilitation engineering
KW  - Human-Computer interaction
KW  - Automatic control
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.ifacol.2019.12.102
SN  - 2405-8963
N1  - 14th IFAC Symposium on Analysis, Design, and Evaluation of Human Machine Systems HMS 2019
Tallinn, Estonia, 16–91 September 2019
VL  - 52
IS  - 19
SP  - 223
EP  - 228
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Kodomskoi, Leonid
A1  - Kotliar, Konstantin
A1  - Schröder, Andreas
A1  - Weiss, Michael
A1  - Hille, Konrad
T1  - Suture-Probe Canaloplasty as an Alternative to Canaloplasty using the iTrack™ Microcatheter
JF  - Journal of Glaucoma
Y1  - 2019
U6  - http://dx.doi.org/10.1097/IJG.0000000000001321
SN  - 1057-0829
IS  - Epub ahead of print
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Kopp, Alexander
A1  - Schmeets, Ralf
A1  - Gosau, Martin
A1  - Friedrich, Reinhard E.
A1  - Fuest, Sandra
A1  - Behbahani, Mehdi
A1  - Barbeck, Mike
A1  - Rutkowski, Rico
A1  - Burg, Simon
A1  - Kluwe, Lan
A1  - Henningsen, Anders
T1  - Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application
JF  - In Vivo
Y1  - 2019
U6  - http://dx.doi.org/10.21873/invivo.11536
SN  - 1791-7549
VL  - 33
IS  - 3
SP  - 757
EP  - 762
ER  - 
TY  - JOUR
A1  - Kramer, Matthias
A1  - Valero, Daniel
A1  - Chanson, Hubert
A1  - Bung, Daniel B.
T1  - Towards reliable turbulence estimations with phase-detection probes: an adaptive window cross-correlation technique
JF  - Experiments in Fluids
Y1  - 2019
U6  - http://dx.doi.org/10.1007/s00348-018-2650-9
SN  - 1432-1114
VL  - 60
EP  - Article number 2
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Krome, Cornelia
A1  - Höft, Jan
A1  - Sander, Volker
T1  - Clustering time series applied to energy markets
JF  - Energy Informatics
Y1  - 2019
U6  - http://dx.doi.org/10.1186/s42162-019-0076-0
SN  - 2520-8942
VL  - 2
IS  - Article numer 17
SP  - 1
EP  - 20
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Kunkel, Maximilian Hugo
A1  - Gebhardt, Andreas
A1  - Mpofu, Khumbulani
A1  - Kallweit, Stephan
T1  - Quality assurance in metal powder bed fusion via deep-learning-based image classification
JF  - Rapid Prototyping Journal
Y1  - 2019
U6  - http://dx.doi.org/10.1108/RPJ-03-2019-0066
SN  - 1355-2546
VL  - 26
IS  - 2
SP  - 259
EP  - 266
ER  - 
TY  - JOUR
A1  - Kurz, Melanie
T1  - Images of Sweden in Germany: from Sundborn and Bullerby to Ikea
JF  - nomad: the magazine for new design culture, business affairs and contemporary lifestyle
Y1  - 2019
SN  - 2513-0714
IS  - 8
SP  - 136
EP  - 147
ER  -