TY - GEN A1 - Machado, Patricia Almeida A1 - Dahmann, Peter A1 - Keimer, Jona A1 - Saretzki, Charlotte A1 - Stübing, Felix A1 - Küpper, Thomas T1 - Stress profile and individual workload monitoring in general aviation pilots – an experiment’s setting T2 - 23. Annual Meeting of the German Society of Travel Medicine, Coburg, 18.-19.9.2020 Y1 - 2020 U6 - https://doi.org/10.55225/hppa.156 ER - TY - JOUR A1 - Malan, Leone A1 - Hamer, Mark A1 - Känel, Roland von A1 - Kotliar, Konstantin A1 - Wyk, Roelof D. van A1 - Lambert, Gavin W. A1 - Vilser, Walthard A1 - Ziemssen, Tjalf A1 - Schlaich, Markus P. A1 - Smith, Wayne A1 - Magnusson, Martin A1 - Wentzel, Annemarie A1 - Myburgh, Carlien E. A1 - Steyn, Hendrik S. A1 - Malan, Nico T. T1 - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study JF - Cardiovascular Journal of Africa Y1 - 2020 U6 - https://doi.org/10.5830/CVJA-2020-031 SN - 1680-0745 VL - 26 IS - 31 SP - 1 EP - 12 PB - Clinics Cardive Publishing CY - Durbanville ER - TY - CHAP A1 - Mansurov, Zulkhair A. A1 - Jandosov, Jakpar A1 - Chenchik, D. A1 - Azat, Seitkhan A1 - Savitskaya, Irina S. A1 - Kistaubaeva, Aida A1 - Akimbekov, Nuraly S. A1 - Digel, Ilya A1 - Zhubanova, Azhar Achmet T1 - Biocomposite Materials Based on Carbonized Rice Husk in Biomedicine and Environmental Applications T2 - Carbon Nanomaterials in Biomedicine and the Environment N2 - This chapter describes the prospects for biomedical and environmental engineering applications of heterogeneous materials based on nanostructured carbonized rice husk. Efforts in engineering enzymology are focused on the following directions: development and optimization of immobilization methods leading to novel biotechnological and biomedical applications; construction of biocomposite materials based on individual enzymes, multi-enzyme complexes and whole cells, targeted on realization of specific industrial processes. Molecular biological and biochemical studies on cell adhesion focus predominantly on identification, isolation and structural analysis of attachment-responsible biological molecules and their genetic determinants. The chapter provides a short overview of applications of the biocomposite materials based of nanostructured carbonized adsorbents. It emphasizes that further studies and better understanding of the interactions between CNS and microbial cells are necessary. The future use of living cells as biocatalysts, especially in the environmental field, needs more systematic investigations of the microbial adsorption phenomenon. Y1 - 2020 SN - 978-981-4800-27-3 U6 - https://doi.org/10.1201/9780429428647-2 SP - 3 EP - 32 PB - Jenny Stanford Publishing Pte. Ltd. CY - Singapore ER - TY - JOUR A1 - Marinkovic, Marko A1 - Butenweg, Christoph T1 - Ausfachungen aus Ziegelmauerwerk in Stahlbetonrahmentragwerken unter Erdbebenbeanspruchung JF - Mauerwerk N2 - Stahlbetonrahmentragwerke mit Ausfachungen aus Mauerwerk weisen nach Erdbeben häufig schwere Schäden auf. Gründe hierfür sind die Beanspruchungen der Ausfachungswände durch die aufgezwungenen Rahmenverformungen in Wandebene und die gleichzeitig auftretenden Trägheitskräfte senkrecht zur Wandebene in Kombination mit der konstruktiven Ausführung des Ausfachungsmauerwerks. Die Ausfachung wird in der Regel knirsch gegen die Rahmenstützen gemauert, wobei der Verschluss der oberen Fuge mit Mörtel oder Montageschaum erfolgt. Dadurch kommt es im Erdbebenfall zu lokalen Interaktionen zwischen Ausfachung und Rahmen, die in der Folge zu einem Versagen einzelner Ausfachungswände oder zu einem sukzessiven Versagen des Gesamtgebäudes führen können. Die beobachteten Schäden waren die Motivation dafür, in dem europäischen Forschungsprojekt INSYSME für Stahlbetonrahmentragwerke mit Ausfachungen aus hochwärmedämmenden Ziegelmauerwerk innovative Lösungen zur Verbesserung des seismischen Verhaltens zu entwickeln. Der vorliegende Beitrag stellt die im Rahmen des Projekts von den deutschen Projektpartnern (Universität Kassel, SDA-engineering GmbH) entwickelten Lösungen vor und vergleicht deren seismisches Verhalten mit der traditionellen Ausführung der Ausfachungswände. Grundlage für den Vergleich sind statisch-zyklische Wandversuche und Simulationen auf Wandebene. Aus den Ergebnissen werden Empfehlungen für die erdbebensichere Auslegung von Stahlbetonrahmentragwerken mit Ausfachungen aus Ziegelmauerwerk abgeleitet. Y1 - 2020 U6 - https://doi.org/10.1002/dama.202000011 SN - 1437-1022 VL - 24 IS - 4 SP - 194 EP - 205 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Marinkovic, Marko A1 - Butenweg, Christoph T1 - Earthquake-proof system for masonry infills in RC frame structures JF - International Journal of Masonry Research and Innovation Y1 - 2020 U6 - https://doi.org/10.1504/IJMRI.2020.106328 SN - 2056-9467 VL - 5 IS - 2 SP - 185 EP - 208 PB - Inderscience Enterprises CY - Olney, Bucks ER - TY - CHAP A1 - Marinkovic, Marko A1 - Butenweg, Christoph T1 - Seismic behaviour of RC frames with uncoupled masonry infills having two storeys or two bays T2 - Brick and Block Masonry - From Historical to Sustainable Masonry. Proceedings of the 17th International Brick/Block Masonry Conference N2 - Reinforced concrete (RC) structures with masonry infills are widely used for several types of buildings all over the world. However, it is well known that traditional masonry infills constructed with rigid contact to the surrounding RC frame performed rather poor in past earthquakes. Masonry infills showed severe in-plane damages and failed in many cases under out-of-plane seismic loading. As the undesired interactions between frames and infills changes the load transfer on building level, complete collapses of buildings were observed. A possible solution is uncoupling of masonry infills to the frame to reduce the infill contribution activated by the frame deformation under horizontal loading. The paper presents numerical simulations on RC frames equipped with the innovative decoupling system INODIS. The system was developed within the European project INSYSME and allows an effective uncoupling of frame and infill. The simulations are carried out with a micro-modelling approach, which is able to predict the complex nonlinear behaviour resulting from the different materials and their interaction. Each brick is modelled individually and connected taking into account nonlinearity of a brick mortar interface. The calibration of the model is based on small specimen tests and experimental results for one bay one storey frame are used for the validation. The validated model is further used for parametric studies on two storey and two bay infilled frames. The response and change of the structural stiffness are analysed and compared to the traditionally infilled frame. The results confirm the effectiveness of the INODIS system with less damage and relatively low contribution of the infill at high drift levels. In contrast to the uncoupled system configurations, traditionally infilled frames experienced brittle failure at rather low drift levels. Y1 - 2020 U6 - https://doi.org/10.1201/9781003098508-72 N1 - 17th International Brick/Block Masonry Conference (17thIB2MaC 2020), July 5-8, 2020, Kraków, Poland SP - 1 EP - 7 PB - CRC Press CY - London ER - TY - CHAP A1 - Marinković, Marko A1 - Butenweg, Christoph T1 - Out-of-plane behavior of decoupled masonry infills under seismic loading T2 - Proceedings of the 17th World Conference on Earthquake Engineering N2 - Masonry is used in many buildings not only for load-bearing walls, but also for non-load-bearing enclosure elements in the form of infill walls. Many studies confirmed that infill walls interact with the surrounding reinforced concrete frame, thus changing dynamic characteristics of the structure. Consequently, masonry infills cannot be neglected in the design process. However, although the relevant standards contain requirements for infill walls, they do not describe how these requirements are to be met concretely. This leads in practice to the fact that the infill walls are neither dimensioned nor constructed correctly. The evidence of this fact is confirmed by the recent earthquakes, which have led to enormous damages, sometimes followed by the total collapse of buildings and loss of human lives. Recently, the increasing effort has been dedicated to the approach of decoupling of masonry infills from the frame elements by introducing the gap in between. This helps in removing the interaction between infills and frame, but raises the question of out-of-plane stability of the panel. This paper presents the results of the experimental campaign showing the out-of-plane behavior of masonry infills decoupled with the system called INODIS (Innovative decoupled infill system), developed within the European project INSYSME (Innovative Systems for Earthquake Resistant Masonry Enclosures in Reinforced Concrete Buildings). Full scale specimens were subjected to the different loading conditions and combinations of in-plane and out-of-plane loading. Out-of-plane capacity of the masonry infills with the INODIS system is compared with traditionally constructed infills, showing that INODIS system provides reliable out-of-plane connection under various loading conditions. In contrast, traditional infills performed very poor in the case of combined and simultaneously applied in-plane and out-of-plane loading, experiencing brittle behavior under small in-plane drifts followed by high out-of-plane displacements. Decoupled infills with the INODIS system have remained stable under out-of-plane loads, even after reaching high in-plane drifts and being damaged. KW - in-plane KW - out-of-plane KW - INODIS KW - earthquake KW - connection detail Y1 - 2020 N1 - 17th World Conference on Earthquake Engineering, Sendai, Japan, September 27 to October 2, 2021 N1 - (Die Konferenz war ursprünglich für den 13-18 September 2020 angesetzt) ER - TY - JOUR A1 - Marinković, Marko A1 - Flores Calvinisti, Santiago A1 - Butenweg, Christoph T1 - Numerical analysis of reinforced concrete frame buildings with decoupled infill walls T1 - Numerička analiza armiranobe tonskih okvirnih zgrada sa izolovanom zidanom ispunom JF - Building Materials and Structures JF - Građevinski materijali i konstrukcije N2 - Reinforced concrete (RC) buildings with masonry infill walls are widely used in many countries all over the world. Although infills are considered as non-structural elements, they significantly change dynamic characteristics of RC frame structures during earthquake excitation. Recently, significant effort was spent on studying decoupled infills, which are isolated from the surrounding frame usually by adding a gap between frame and infill. In this case, the frame deformation does not activate infill wall, thus infills are not influencing the behaviour of the frame. This paper presents the results of the investigation of the behaviour of RC frame buildings with the INODIS system that decouples masonry infills from the surrounding frame. Effect of masonry infill decoupling was investigated first on the one-bay onestorey frame. This was used as a base for parametric study on the frames with more bays and storeys, as well as on the building level. Change of stiffness and dynamic characteristics was analysed as well as response under earthquake loading. Comparison with the bare frame and traditionally infilled frame was performed. The results show that behaviour of the decoupled infilled frames is similar to the bare frame, whereas behaviour of frames with traditional infills is significantly different and demands complex numerical models. This means that if adequate decoupling is applied, design of N2 - Armiranobetonske (AB) zgrade sa zidanom ispunom se izvode u mnogim zemljama širom sveta. Iako se zidana ispuna posmatra kao nekonstruktivni element, ona značajno utiče na promenu dinamičkih karakteristika AB ramovskih konstrukcija u toku zemljotresnog dejstva. Odskora, značajan napor je utrošen na istraživanje izolovanih ispuna, koje su odvojene od okolnog rama obično ostavljanjem prostora između rama i ispune. U ovom slučaju deformacija rama ne aktivira ispunu i na taj način ispuna ne utiče na ponašanje rama. Ovaj rad predstavlja rezultate istraživanja ponašanja AB ramovskih zgrada sa INODIS sistemom koji izoluje ispunu u odnosu na okolni ram. Uticaj izolovane ispune je prvo ispitan na jednospratnim i jednobrodnim ramovima. Ovo je iskorišćeno kao osnova za parametarsku analizu na višespratnim i višebrodnim ramovima, kao i na primeru zgrade. Promena krutosti i dinamičkih karakteristika je analizirano kao i odgovor pri zemljotresnom dejstvu. Izvršeno je poređenje sa praznom ramovskom konstrukcijom kao i ramovima ispunjenim ispunom na tradicionalni način. Rezultati pokazuju da je ponašanje ramova sa izolovanom ispunom slično ponašanju praznih ramova, dok je ponašanje ramova sa tradicionalnom ispunom daleko drugačije i zahteva kompleksne numeričke modele. Ovo znači da ukoliko se primeni adekvatna konstruktivna mera izolacije ispune, proračun ramovskim zgrada sa zidanom ispunom se može značajno pojednostaviti. KW - masonry infill KW - seismic KW - INODIS KW - in-plane behaviour KW - out-of-plane behaviour Y1 - 2020 U6 - https://doi.org/10.5937/GRMK2004013M SN - 2217-8139 N1 - Text serbisch, ab 2011 serbisch und englisch VL - 63 IS - 4 SP - 13 EP - 48 PB - Society for Materials and Structures Testing of Serbia CY - Belgrad ER - TY - CHAP A1 - Markinkovic, Marko A1 - Butenweg, Christoph A1 - Pavese, A. A1 - Lanese, I. A1 - Hoffmeister, B. A1 - Pinkawa, M. A1 - Vulcu, C. A1 - Bursi, O. A1 - Nardin, C. A1 - Paolacci, F. A1 - Quinci, G. A1 - Fragiadakis, M. A1 - Weber, F. A1 - Huber, P. A1 - Renault, P. A1 - Gündel, M. A1 - Dyke, S. A1 - Ciucci, M. A1 - Marino, A. T1 - Investigation of the seismic behaviour of structural and nonstructural components in industrial facilities by means of shaking table tests T2 - Seismic design of industrial facilities 2020 Y1 - 2020 SN - 978-3-86359-729-0 N1 - 2nd International Conference on Seismic Design of Industrial Facilities (Aachen, Germany, March 4-5, 2020) SP - 159 EP - 172 PB - Apprimus Verlag CY - Aachen ER - TY - JOUR A1 - Martín-Vaquero, J. A1 - Kleefeld, Andreas T1 - Solving nonlinear parabolic PDEs in several dimensions: Parallelized ESERK codes JF - Journal of Computational Physics N2 - There is a very large number of very important situations which can be modeled with nonlinear parabolic partial differential equations (PDEs) in several dimensions. In general, these PDEs can be solved by discretizing in the spatial variables and transforming them into huge systems of ordinary differential equations (ODEs), which are very stiff. Therefore, standard explicit methods require a large number of iterations to solve stiff problems. But implicit schemes are computationally very expensive when solving huge systems of nonlinear ODEs. Several families of Extrapolated Stabilized Explicit Runge-Kutta schemes (ESERK) with different order of accuracy (3 to 6) are derived and analyzed in this work. They are explicit methods, with stability regions extended, along the negative real semi-axis, quadratically with respect to the number of stages s, hence they can be considered to solve stiff problems much faster than traditional explicit schemes. Additionally, they allow the adaptation of the step length easily with a very small cost. Two new families of ESERK schemes (ESERK3 and ESERK6) are derived, and analyzed, in this work. Each family has more than 50 new schemes, with up to 84.000 stages in the case of ESERK6. For the first time, we also parallelized all these new variable step length and variable number of stages algorithms (ESERK3, ESERK4, ESERK5, and ESERK6). These parallelized strategies allow to decrease times significantly, as it is discussed and also shown numerically in two problems. Thus, the new codes provide very good results compared to other well-known ODE solvers. Finally, a new strategy is proposed to increase the efficiency of these schemes, and it is discussed the idea of combining ESERK families in one code, because typically, stiff problems have different zones and according to them and the requested tolerance the optimum order of convergence is different. KW - Multi-dimensional partial differential equations KW - Higher-order codes KW - Nonlinear PDEs Y1 - 2020 U6 - https://doi.org/10.1016/j.jcp.2020.109771 SN - 0021-9991 IS - 423 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Maurischat, Andreas A1 - Perkins, Rudolph T1 - Taylor coefficients of Anderson generating functions and Drinfeld torsion extensions N2 - We generalize our work on Carlitz prime power torsion extension to torsion extensions of Drinfeld modules of arbitrary rank. As in the Carlitz case, we give a description of these extensions in terms of evaluations of Anderson generating functions and their hyperderivatives at roots of unity. We also give a direct proof that the image of the Galois representation attached to the p-adic Tate module lies in the p-adic points of the motivic Galois group. This is a generalization of the corresponding result of Chang and Papanikolas for the t-adic case. Y1 - 2020 U6 - https://doi.org/10.1142/S1793042122500099 IS - Vol. 18, No. 01 SP - 113 EP - 130 PB - World Scientific CY - Singapur ER - TY - CHAP A1 - Meck, Marvin M. A1 - Müller, Tim M. A1 - Altherr, Lena A1 - Pelz, Peter F. T1 - Improving an industrial cooling system using MINLP, considering capital and operating costs T2 - Operations Research Proceedings 2019 N2 - The chemical industry is one of the most important industrial sectors in Germany in terms of manufacturing revenue. While thermodynamic boundary conditions often restrict the scope for reducing the energy consumption of core processes, secondary processes such as cooling offer scope for energy optimisation. In this contribution, we therefore model and optimise an existing cooling system. The technical boundary conditions of the model are provided by the operators, the German chemical company BASF SE. In order to systematically evaluate different degrees of freedom in topology and operation, we formulate and solve a Mixed-Integer Nonlinear Program (MINLP), and compare our optimisation results with the existing system. KW - Engineering optimisation KW - Mixed-integer programming KW - Industrial optimisation KW - Cooling system KW - Process engineering Y1 - 2020 SN - 978-3-030-48438-5 (Print) SN - 978-3-030-48439-2 (Online) U6 - https://doi.org/10.1007/978-3-030-48439-2_61 N1 - Annual International Conference of the German Operations Research Society (GOR), Dresden, Germany, September 4-6, 2019. SP - 505 EP - 512 PB - Springer CY - Cham ER - TY - JOUR A1 - Mennicken, Max A1 - Peter, Sophia K. A1 - Kaulen, Corinna A1 - Simon, Ulrich A1 - Karthäuser, Silvia T1 - Transport through Redox-Active Ru-Terpyridine Complexes Integrated in Single Nanoparticle Devices JF - The Journal of Physical Chemistry C N2 - Transition metal complexes are electrofunctional molecules due to their high conductivity and their intrinsic switching ability involving a metal-to-ligand charge transfer. Here, a method is presented to contact reliably a few to single redox-active Ru-terpyridine complexes in a CMOS compatible nanodevice and preserve their electrical functionality. Using hybrid materials from 14 nm gold nanoparticles (AuNP) and bis-{4′-[4-(mercaptophenyl)-2,2′:6′,2″-terpyridine]}-ruthenium(II) complexes a device size of 30² nm² inclusive nanoelectrodes is achieved. Moreover, this method bears the opportunity for further downscaling. The Ru-complex AuNP devices show symmetric and asymmetric current versus voltage curves with a hysteretic characteristic in two well separated conductance ranges. By theoretical approximations based on the single-channel Landauer model, the charge transport through the formed double-barrier tunnel junction is thoroughly analyzed and its sensibility to the molecule/metal contact is revealed. It can be verified that tunneling transport through the HOMO is the main transport mechanism while decoherent hopping transport is present to a minor extent. Y1 - 2020 U6 - https://doi.org/10.1021/acs.jpcc.9b11716 SN - 1932-7455 VL - 124 IS - 8 SP - 4881 EP - 4889 PB - ACS Publications CY - Washington, DC ER - TY - JOUR A1 - Meyer, S. A1 - Hänel, Matthias A1 - Beeh, B. A1 - Dittmann-Gabriel, Sören A1 - Dluhosch, R. A1 - May, Martin A1 - Herrmann, Ulf T1 - Multifunktionaler thermischer Stromspeicher für die Strom- und Wärmeversorgung der Industrie von morgen JF - ETG Journal / Energietechnische Gesellschaft im VDE (ETG) Y1 - 2020 SN - 2625-9907 VL - 2020 IS - 1 SP - 6 EP - 9 ER - TY - JOUR A1 - Michel, P. A1 - Butenweg, Christoph A1 - Klinkel, S. T1 - Einfluss der dynamischen Steifigkeit von Flach-und Pfahlgründungen auf die Dynamik von Onshore-Windenergieanlagen JF - Bauingenieur Y1 - 2020 SN - 0005-6650 VL - 95 IS - 4 SP - 139 EP - 146 PB - VDI Fachmedien CY - Düsseldorf ER - TY - CHAP A1 - Michel, Philipp A1 - Rosin, Julia A1 - Butenweg, Christoph A1 - Klinkel, Sven T1 - Soil-dependent earthquake spectra in the analysis of liquid-storage-tanks on compliant soil T2 - Seismic design of industrial facilities 2020 N2 - A further development of the Added-Mass-Method allows the combined representation of the effects of both soil-structure-interaction and fluid-structure interaction on a liquid-filled-tank in one model. This results in a practical method for describing the dynamic fluid pressure on the tank shell during joint movement. The fluid pressure is calculated on the basis of the tank's eigenform and the earthquake acceleration and represented by additional masses on the shell. The bearing on compliant ground is represented by replacement springs, which are calculated dependent on the local soil composition. The influence of the shear modulus of the compliant soil is clearly visible in the pressure curves and the stress distribution in the shell. The acceleration spectra are also dependent on soil stiffness. According to Eurocode-8 the acceleration spectra are determined for fixed soil-classes, instead of calculating the accelerations for each site in direct dependence on the soil composition. This leads to unrealistic sudden changes in the system's response. Therefore, earthquake spectra are calculated for different soil models in direct dependence of the shear modulus. Thus, both the acceleration spectra and the replacement springs match the soil composition. This enables a reasonable and consistent calculation of the system response for the actual conditions at each site. Y1 - 2020 SN - 978-3-86359-729-0 N1 - 2nd International Conference on Seismic Design of Industrial Facilities (Aachen, Germany, March 4-5, 2020) SP - 245 EP - 254 PB - Apprimus Verlag CY - Aachen ER - TY - CHAP A1 - Milkova, Kristina A1 - Butenweg, Christoph A1 - Dumova-Jovanoska, Elena T1 - Methodology for development of seismic vulnerability curve for existing unreinforced Masonry buildings T2 - Proceedings of the 17th World Conference on Earthquake Engineering N2 - Seismic behavior of an existing unreinforced masonry building built pre-modern code, located in the City of Ohrid, Republic of North Macedonia has been investigated in this paper. The analyzed school building is selected as an archetype in an ongoing project named “Seismic vulnerability assessment of existing masonry structures in Republic of North Macedonia (SeismoWall)”. Two independent segments were included in this research: Seismic hazard assessment by creating a cite specific response spectra and Seismic vulnerability definition by creating a region - specific series of vulnerability curves for the chosen building topology. A reliable Seismic Hazard Assessment for a selected region is a crucial point for performing a seismic risk analysis of a characteristic building class. In that manner, a scenario – based method that incorporates together the knowledge of tectonic style of the considered region, the active fault characterization, the earth crust model and the historical seismicity named Neo Deterministic approach is used for calculation of the response spectra for the location of the building. Variations of the rupturing process are taken into account in the nucleation point of the rupture, in the rupture velocity pattern and in the istribution of the slip on the fault. The results obtained from the multiple scenarios are obtained as an envelope of the response spectra computed for the cite using the procedure Maximum Credible Seismic Input (MCSI). Capacity of the selected building has been determined by using nonlinear static analysis. MINEA software (SDA Engineering) was used for verification of the structural safety of the chosen unreinforced masonry structure. In the process of optimization of the number of samples, computational cost required in a Monte Carlo simulation is significantly reduced since the simulation is performed on a polynomial response surface function for prediction of the structural response. Performance point, found as the intersection of the capacity of the building and the spectra used, is chosen as a response parameter. Five levels of damage limit states based on the capacity curve of the building are defined in dependency on the yield displacement and the maximum displacement. Maximum likelihood estimation procedure is utilized in the process of vulnerability curves determination. As a result, region specific series of vulnerability curves for the chosen type of masonry structures are defined. The obtained probabilities of exceedance a specific damage states as a result from vulnerability curves are compared with the observed damages happened after the earthquake in July 2017 in the City of Ohrid, North Macedonia. KW - Masonry structures KW - Vulnerability Curves KW - Capacity Curve KW - Neo-Deterministic KW - Seismic Hazard Y1 - 2020 N1 - 17th World Conference on Earthquake Engineering, Sendai, Japan, September 27 to October 2, 2021 N1 - (Die Konferenz war ursprünglich für den 13-18 September 2020 angesetzt) ER - TY - JOUR A1 - Molinnus, Denise A1 - Beging, Stefan A1 - Lowis, Carsten A1 - Schöning, Michael Josef T1 - Towards a multi-enzyme capacitive field-effect biosensor by comparative study of drop-coating and nano-spotting technique JF - Sensors N2 - Multi-enzyme immobilization onto a capacitive field-effect biosensor by nano-spotting technique is presented. The nano-spotting technique allows to immobilize different enzymes simultaneously on the sensor surface with high spatial resolution without additional photolithographical patterning. The amount of applied enzymatic cocktail on the sensor surface can be tailored. Capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors with Ta2O5 as pH-sensitive transducer layer have been chosen to immobilize the three different (pL droplets) enzymes penicillinase, urease, and glucose oxidase. Nano-spotting immobilization is compared to conventional drop-coating method by defining different geometrical layouts on the sensor surface (fully, half-, and quarter-spotted). The drop diameter is varying between 84 µm and 102 µm, depending on the number of applied drops (1 to 4) per spot. For multi-analyte detection, penicillinase and urease are simultaneously nano-spotted on the EIS sensor. Sensor characterization was performed by C/V (capacitance/voltage) and ConCap (constant capacitance) measurements. Average penicillin, glucose, and urea sensitivities for the spotted enzymes were 81.7 mV/dec, 40.5 mV/dec, and 68.9 mV/dec, respectively. Y1 - 2020 SN - 1424-8220 U6 - https://doi.org/10.3390/s20174924 N1 - Special issue: Multisensor Systems and Signal Processing in Analytical Chemistry VL - 20 IS - 17 PB - MDPI CY - Basel ER - TY - JOUR A1 - Morat, Mareike A1 - Faude, Oliver A1 - Hanssen, Henner A1 - Ludyga, Sebastian A1 - Zacher, Jonas A1 - Eibl, Angi A1 - Albracht, Kirsten A1 - Donath, Lars T1 - Agility Training to Integratively Promote Neuromuscular, Cognitive, Cardiovascular and Psychosocial Function in Healthy Older Adults: A Study Protocol of a One-Year Randomized-Controlled Trial JF - International Journal of Environmental Research and Public Health N2 - Exercise training effectively mitigates aging-induced health and fitness impairments. Traditional training recommendations for the elderly focus separately on relevant physiological fitness domains, such as balance, flexibility, strength and endurance. Thus, a more holistic and functional training framework is needed. The proposed agility training concept integratively tackles spatial orientation, stop and go, balance and strength. The presented protocol aims at introducing a two-armed, one-year randomized controlled trial, evaluating the effects of this concept on neuromuscular, cardiovascular, cognitive and psychosocial health outcomes in healthy older adults. Eighty-five participants were enrolled in this ongoing trial. Seventy-nine participants completed baseline testing and were block-randomized to the agility training group or the inactive control group. All participants undergo pre- and post-testing with interim assessment after six months. The intervention group currently receives supervised, group-based agility training twice a week over one year, with progressively demanding perceptual, cognitive and physical exercises. Knee extension strength, reactive balance, dual task gait speed and the Agility Challenge for the Elderly (ACE) serve as primary endpoints and neuromuscular, cognitive, cardiovascular, and psychosocial meassures serve as surrogate secondary outcomes. Our protocol promotes a comprehensive exercise training concept for older adults, that might facilitate stakeholders in health and exercise to stimulate relevant health outcomes without relying on excessively time-consuming physical activity recommendations. KW - agility KW - prevention KW - healthy aging KW - community dwelling KW - psychosocial Y1 - 2020 U6 - https://doi.org/10.3390/ijerph17061853 SN - 1660-4601 VL - 17 IS - 6 SP - 1 EP - 14 PB - MDPI CY - Basel ER - TY - JOUR A1 - Moret, J.L.T.M. A1 - Alkemade, J. A1 - Upcraft, T.M. A1 - Paulßen, Elisabeth A1 - Wolterbeek, H.T. A1 - Ommen, J.R. van A1 - Denkova, A.G. T1 - The application of atomic layer deposition in the production of sorbents for ⁹⁹Mo/⁹⁹ᵐTc generator JF - Applied Radiation and Isotopes N2 - New production routes for ⁹⁹Mo are steadily gaining importance. However, the obtained specific activity is much lower than currently produced by the fission of U-235. To be able to supply hospitals with ⁹⁹Mo/⁹⁹ᵐTc generators with the desired activity, the adsorption capacity of the column material should be increased. In this paper we have investigated whether the gas phase coating technique Atomic Layer Deposition (ALD), which can deposit ultra-thin layers on high surface area materials, can be used to attain materials with high adsorption capacity for ⁹⁹Mo. For this purpose, ALD was applied on a silica-core sorbent material to coat it with a thin layer of alumina. This sorbent material shows to have a maximum adsorption capacity of 120 mg/g and has a ⁹⁹ᵐTc elution efficiency of 55 ± 2% based on 3 executive elutions. Y1 - 2020 U6 - https://doi.org/10.1016/j.apradiso.2020.109266 SN - 0969-8043 VL - 164 IS - 109266 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Muschallik, Lukas A1 - Kipp, Carina Ronja A1 - Recker, Inga A1 - Bongaerts, Johannes A1 - Pohl, Martina A1 - Gelissen, Melanie A1 - Schöning, Michael Josef A1 - Selmer, Thorsten A1 - Siegert, Petra T1 - Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase JF - Journal of Biotechnology N2 - The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled. Y1 - 2020 SN - 2590-1559 U6 - https://doi.org/10.1016/j.jbiotec.2020.09.016 VL - 202 IS - Vol. 324 SP - 61 EP - 70 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Muschallik, Lukas A1 - Molinnus, Denise A1 - Jablonski, Melanie A1 - Kipp, Carina Ronja A1 - Bongaerts, Johannes A1 - Pohl, Martina A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Selmer, Thorsten A1 - Siegert, Petra T1 - Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase JF - RSC Advances N2 - α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated. Y1 - 2020 U6 - https://doi.org/10.1039/D0RA02066D SN - 2046-2069 VL - 10 SP - 12206 EP - 12216 PB - Royal Society of Chemistry (RSC) CY - Cambridge ER - TY - BOOK A1 - Mühl, Thomas T1 - Elektrische Messtechnik: Grundlagen, Messverfahren, Anwendungen Y1 - 2020 SN - 978-3-658-29115-0 U6 - https://doi.org/10.1007/978-3-658-29116-7 N1 - gedruckt in der Bereichsbibliothek Eupener Str. unter der Signatur 21 XXA 15(6); auch als Online-Ressource ISBN 978-3-658-29116-7 PB - Springer Vieweg CY - Wiesbaden ET - 6., überarbeitete Auflage ER - TY - CHAP A1 - Müller, Tim M. A1 - Altherr, Lena A1 - Leise, Philipp A1 - Pelz, Peter F. T1 - Optimization of pumping systems for buildings: Experimental validation of different degrees of model detail on a modular test rig T2 - Operations Research Proceedings 2019 N2 - Successful optimization requires an appropriate model of the system under consideration. When selecting a suitable level of detail, one has to consider solution quality as well as the computational and implementation effort. In this paper, we present a MINLP for a pumping system for the drinking water supply of high-rise buildings. We investigate the influence of the granularity of the underlying physical models on the solution quality. Therefore, we model the system with a varying level of detail regarding the friction losses, and conduct an experimental validation of our model on a modular test rig. Furthermore, we investigate the computational effort and show that it can be reduced by the integration of domain-specific knowledge. KW - Experimental validation KW - MINLP KW - Engineering optimization KW - Water supply system KW - Network design Y1 - 2020 SN - 978-3-030-48438-5 U6 - https://doi.org/10.1007/978-3-030-48439-2_58 N1 - Annual International Conference of the German Operations Research Society (GOR), Dresden, Germany, September 4-6, 2019 SP - 481 EP - 488 PB - Springer CY - Cham ER - TY - JOUR A1 - Müller, Tim M. A1 - Leise, Philipp A1 - Lorenz, Imke-Sophie A1 - Altherr, Lena A1 - Pelz, Peter F. T1 - Optimization and validation of pumping system design and operation for water supply in high-rise buildings JF - Optimization and Engineering N2 - The application of mathematical optimization methods for water supply system design and operation provides the capacity to increase the energy efficiency and to lower the investment costs considerably. We present a system approach for the optimal design and operation of pumping systems in real-world high-rise buildings that is based on the usage of mixed-integer nonlinear and mixed-integer linear modeling approaches. In addition, we consider different booster station topologies, i.e. parallel and series-parallel central booster stations as well as decentral booster stations. To confirm the validity of the underlying optimization models with real-world system behavior, we additionally present validation results based on experiments conducted on a modularly constructed pumping test rig. Within the models we consider layout and control decisions for different load scenarios, leading to a Deterministic Equivalent of a two-stage stochastic optimization program. We use a piecewise linearization as well as a piecewise relaxation of the pumps’ characteristics to derive mixed-integer linear models. Besides the solution with off-the-shelf solvers, we present a problem specific exact solving algorithm to improve the computation time. Focusing on the efficient exploration of the solution space, we divide the problem into smaller subproblems, which partly can be cut off in the solution process. Furthermore, we discuss the performance and applicability of the solution approaches for real buildings and analyze the technical aspects of the solutions from an engineer’s point of view, keeping in mind the economically important trade-off between investment and operation costs. KW - Technical Operations Research KW - MINLP KW - MILP KW - Experimental validation KW - Pumping systems Y1 - 2020 U6 - https://doi.org/10.1007/s11081-020-09553-4 SN - 1573-2924 VL - 2021 IS - 22 SP - 643 EP - 686 PB - Springer ER - TY - CHAP A1 - Nees, Franz A1 - Stengel, Ingo A1 - Meister, Vera G. A1 - Barton, Thomas A1 - Herrmann, Frank A1 - Müller, Christian A1 - Wolf, Martin T1 - Angewandte Forschung in der Wirtschaftsinformatik 2020 : Tagungsband zur 33. AKWI-Jahrestagung am 14.09.2020, ausgerichtet von der Hochschule Karlsruhe - Wirtschaft und Technik / hrsg. von Franz Nees, Ingo Stengel, Vera G. Meister, Thomas Barton, Frank Herrmann, Christian Müller, Martin R. Wolf N2 - Tagungsbeiträge aus den Bereichen KI, Prozessorganisation und Plattformen für Geschäftsprozesse, Sicherheit und Datenschutz sowie Prototypen und Modelle. Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-13840 SN - 978-3-944330-66-2 N1 - 33. AKWI-Jahrestagung am 14.09.2020, ausgerichtet von der Hochschule Karlsruhe - Wirtschaft und Technik PB - mana-Buch CY - Heide ER - TY - JOUR A1 - Nobis, Moritz A1 - Schmitt, Carlo A1 - Schemm, Ralf A1 - Schnettler, Armin T1 - Pan-European CVAR-constrained stochastic unit commitment in day-ahead and intraday electricity markets JF - Energies N2 - The fundamental modeling of energy systems through individual unit commitment decisions is crucial for energy system planning. However, current large-scale models are not capable of including uncertainties or even risk-averse behavior arising from forecasting errors of variable renewable energies. However, risks associated with uncertain forecasting errors have become increasingly relevant within the process of decarbonization. The intraday market serves to compensate for these forecasting errors. Thus, the uncertainty of forecasting errors results in uncertain intraday prices and quantities. Therefore, this paper proposes a two-stage risk-constrained stochastic optimization approach to fundamentally model unit commitment decisions facing an uncertain intraday market. By the nesting of Lagrangian relaxation and an extended Benders decomposition, this model can be applied to large-scale, e.g., pan-European, power systems. The approach is applied to scenarios for 2023—considering a full nuclear phase-out in Germany—and 2035—considering a full coal phase-out in Germany. First, the influence of the risk factors is evaluated. Furthermore, an evaluation of the market prices shows an increase in price levels as well as an increasing day-ahead-intraday spread in 2023 and in 2035. Finally, it is shown that intraday cross-border trading has a significant influence on trading volumes and prices and ensures a more efficient allocation of resources. Y1 - 2020 U6 - https://doi.org/10.3390/en13092339 SN - 1996-1073 N1 - Special Issue Uncertainties and Risk Management in Competitive Energy Markets VL - 13 IS - Art. 2339 SP - 1 EP - 35 PB - MDPI CY - Basel ER - TY - CHAP A1 - Oetringer, Kerstin A1 - Dümmler, Andreas A1 - Göttsche, Joachim T1 - Neues Modell zur 1D-Simulation der indirekten Verdunstungskühlung T2 - DKV‐Tagung 2020, AA II.1 N2 - Im Projekt Coolplan‐ AIR geht es um die Fortentwicklung und Feld‐ Validierung eines Berechnungs‐ und Auslegungstools zur energieeffizienten Kühlung von Gebäuden mit luftgestützten Systemen. Neben dem Aufbau und der Weiterentwicklung von Simulationsmodellen erfolgen Vermessungen der Gesamtsysteme anhand von Praxisanlagen im Feld. Eine der betrachteten Anlagen arbeitet mit indirekter Verdunstung. Diese Veröffentlichung zeigt den Entwicklungsprozess und den Aufbau des Simulationsmodells zur Verdunstungskühlung in der Simulationsumgebung Matlab‐ Simulink mit der CARNOT‐ Toolbox. Das besondere Augenmerk liegt dabei auf dem physikalischen Modell des Wärmeübertragers, in dem die Verdunstung implementiert ist. Dem neuen Modellansatz liegt die Annahme einer aus der Enthalpie‐ Betrachtung hergeleiteten effektiven Wärmekapazität zugrunde. Des Weiteren wird der Befeuchtungsgrad als konstant angesehen und eine standardisierte Zunahme der Wärmeübertragung des feuchten gegenüber dem trockenen Wärmeübertrager angenommen. Die Validierung des Modells erfolgte anhand von Literaturdaten. Für den trockenen Wärmetauscher ist der maximale absolute Fehler der berechneten Austrittstemperatur (Zuluft) kleiner als ±0.1 K und für den nassen Wärmetauscher (Kühlfall) unter der Annahme eines konstanten Verdunstungsgrades kleiner als ±0.4 K. Y1 - 2020 N1 - Deutsche Kälte- und Klimatagung, 19-20 November 2020, online SP - 250 EP - 262 ER - TY - GEN A1 - Ohrtmann, Jan-Peter A1 - Golland, Alexander T1 - Daten- und Privatsphäreschutz im Wandel der 2020er-Jahre Y1 - 2020 SP - 33 EP - 38 ER - TY - JOUR A1 - Olbertz, Klaus T1 - Jahresrückblick Arbeitsrecht 2019 : Gesetzesänderungen und insbesondere im Zeichen des Befristungs- und Urlaubsrechts stehende höchstrichterliche Rechtsprechung JF - NWB - Steuer- und Wirtschaftsrecht N2 - In Fortschreibung des Jahresrückblicks 2018 (Olbertz, NWB 5/2019 S. 266 ) skizziert der vorliegende Beitrag die jüngsten nennenswerten Entwicklungen im Arbeitsrecht des Jahres 2019. Im Bereich der Gesetzgebung, mit dem sich der erste Teil des Beitrags befasst, betrifft dies etwa das Fachkräfteeinwanderungsgesetz, die angestoßenen Schutzvorschriften für Whistleblower oder das gesetzlich verankerte Recht auf Brückenteilzeit. In der arbeitsrechtlichen höchstrichterlichen Rechtsprechung stand das Jahr 2019 insbesondere im Zeichen des Befristungs- und des Urlaubsrechts. Was hier und darüber hinaus wegweisend war, zeigt der zweite Teil des Beitrags. Y1 - 2020 SN - 0028-3460 IS - 8 SP - 557 EP - 569 PB - NWB-Verl. CY - Herne ER - TY - JOUR A1 - Olbertz, Klaus T1 - GmbH-Geschäftsführer: das eine Mal Arbeitnehmer, das andere Mal nicht : Arbeits- und sozialrechtliche Anwendung von Schutzvorschriften auf den Geschäftsführer von A bis Z JF - NWB - Steuer- und Wirtschaftsrecht Y1 - 2020 SN - 0028-3460 IS - 19 SP - 1431 EP - 1441 PB - NWB-Verl. CY - Herne ER - TY - JOUR A1 - Olbertz, Klaus T1 - Wenn der „leitende“ Angestellte doch nur ein „normaler“ Arbeitnehmer ist ... : Zur Rechtsstellung leitender Angestellter, zu Fehleinschätzungen des Arbeitgebers und Praxishinweisen JF - NWB - Steuer- und Wirtschaftsrecht Y1 - 2020 SN - 0028-3460 IS - 32 SP - 2397 EP - 2406 PB - NWB-Verl. CY - Herne ER - TY - JOUR A1 - Orzada, Stephan A1 - Fiedler, Thomas M. A1 - Bitz, Andreas A1 - Ladd, Mark E. A1 - Quick, Harald H. T1 - Local SAR compression with overestimation control to reduce maximum relative SAR overestimation and improve multi-channel RF array performance JF - Magnetic Resonance Materials in Physics, Biology and Medicine N2 - Objective In local SAR compression algorithms, the overestimation is generally not linearly dependent on actual local SAR. This can lead to large relative overestimation at low actual SAR values, unnecessarily constraining transmit array performance. Method Two strategies are proposed to reduce maximum relative overestimation for a given number of VOPs. The first strategy uses an overestimation matrix that roughly approximates actual local SAR; the second strategy uses a small set of pre-calculated VOPs as the overestimation term for the compression. Result Comparison with a previous method shows that for a given maximum relative overestimation the number of VOPs can be reduced by around 20% at the cost of a higher absolute overestimation at high actual local SAR values. Conclusion The proposed strategies outperform a previously published strategy and can improve the SAR compression where maximum relative overestimation constrains the performance of parallel transmission. Y1 - 2020 SN - 1352-8661 U6 - https://doi.org/10.1007/s10334-020-00890-0 IS - 34 (2021) SP - 153 EP - 164 PB - Springer CY - Heidelberg ER - TY - CHAP A1 - Paulsen, Svea A1 - Hoffstadt, Kevin A1 - Krafft, Simone A1 - Leite, A. A1 - Zang, J. A1 - Fonseca-Zang, W. A1 - Kuperjans, Isabel T1 - Continuous biogas production from sugarcane as sole substrate T2 - Energy Reports N2 - A German–Brazilian research project investigates sugarcane as an energy plant in anaerobic digestion for biogas production. The aim of the project is a continuous, efficient, and stable biogas process with sugarcane as the substrate. Tests are carried out in a fermenter with a volume of 10 l. In order to optimize the space–time load to achieve a stable process, a continuous process in laboratory scale has been devised. The daily feed in quantity and the harvest time of the substrate sugarcane has been varied. Analyses of the digester content were conducted twice per week to monitor the process: The ratio of inorganic carbon content to volatile organic acid content (VFA/TAC), the concentration of short-chain fatty acids, the organic dry matter, the pH value, and the total nitrogen, phosphate, and ammonium concentrations were monitored. In addition, the gas quality (the percentages of CO₂, CH₄, and H₂) and the quantity of the produced gas were analyzed. The investigations have exhibited feasible and economical production of biogas in a continuous process with energy cane as substrate. With a daily feeding rate of 1.68gᵥₛ/l*d the average specific gas formation rate was 0.5 m3/kgᵥₛ. The long-term study demonstrates a surprisingly fast metabolism of short-chain fatty acids. This indicates a stable and less susceptible process compared to other substrates. Y1 - 2020 U6 - https://doi.org/10.1016/j.egyr.2019.08.035 N1 - 6th International Conference on Energy and Environment Research, ICEER 2019, 22–25 July, University of Aveiro, Portugal VL - 6 IS - Supplement 1 SP - 153 EP - 158 PB - Elsevier ER - TY - JOUR A1 - Peterson-Oster, Madeleine A1 - Peterson, Leif Arne T1 - Fassadensystem: Optisch ansprechend, freistehend, elementiert und aus Eichenholz JF - Bauen mit Holz, Der Zimmermann N2 - Bei der Entwicklung des Fassadensystems ging es darum die mögliche Dauerhaftigkeit von Holz bei direkter Bewitterung zu maximieren. Gleichzeitig soll gezeigt werden, dass mittels durchdachter Ansätze beim konstruktiven Holzschutz und die Wahl einer geeigneten Holzart langlebige Konstruktionen realisiert werden können. Y1 - 2020 SN - 0005-6545 PB - Rudolf Müller CY - Köln ER - TY - JOUR A1 - Peterson-Oster, Madeleine A1 - Peterson, Leif Arne T1 - Gewerbebau: Modellprojekt mit neuem elementiertem, freistehendem Fassadensystem JF - Bauen mit Holz, Der Zimmermann N2 - Die im Zuge einer Betriebsübergabe anstehende Baumaßnahmen am eigenen Büro- und Produktionsgebäude boten ideale Voraussetzung zur Anwendung einer raum­-kreierenden Außenhaut. Mit der elementierten, freistehenden Eichenholz-Fassade wurde ein bis dahin weitgehend funktionales Bauwerk substanzschonend und zugleich optisch ansprechender umgestaltet. Y1 - 2020 SN - 0005-6545 PB - Rudolf Müller CY - Köln ER - TY - JOUR A1 - Pfaff, Raphael A1 - Gidaszewski, Lars A1 - Schmidt, Bernd T1 - Berücksichtigung von No Fault Found im Diagnose- und Instandhaltungssystem von Schienenfahrzeugen JF - ETR - Eisenbahntechnische Rundschau N2 - Intermittierende und nicht reproduzierbare Fehler, auch als No Fault Found bezeichnet, treten in praktisch allen Bereichen auf und sorgen für hohe Kosten. Diese sind häufig auf unpräzise Fehlerbeschreibungen zurückzuführen. Im vorliegenden Beitrag werden Anpassungen der Vorgehensweise bei der Entwicklung und Anpassungen des Diagnosesystems vorgeschlagen. Y1 - 2020 SN - 0013-2845 IS - 5 SP - 56 EP - 59 PB - DVV Media Group CY - Hamburg ER - TY - CHAP A1 - Philipp, Brauner A1 - Brillowski, Florian Sascha A1 - Dammers, Hannah A1 - Königs, Peter A1 - Kordtomeikel, Frauke Carole A1 - Petruck, Henning A1 - Schaar, Anne Kathrin A1 - Schmitz, Seth A1 - Steuer-Dankert, Linda A1 - Mertens, Alexander A1 - Gries, Thomas A1 - Leicht-Scholten, Carmen A1 - Nagel, Saskia K. A1 - Nitsch, Verena A1 - Schuh, Günther A1 - Ziefle, Martina ED - Mrugalska, Beata ED - Trzcielinski, Stefan ED - Karwowski, Waldemar ED - Nicolantonio, Massimo Di ED - Roossi, Emilio T1 - A research framework for human aspects in the internet of production: an intra-company perspective T2 - Proceedings of the AHFE 2020 N2 - Digitalization in the production sector aims at transferring concepts and methods from the Internet of Things (IoT) to the industry and is, as a result, currently reshaping the production area. Besides technological progress, changes in work processes and organization are relevant for a successful implementation of the “Internet of Production” (IoP). Focusing on the labor organization and organizational procedures emphasizes to consider intra-company factors such as (user) acceptance, ethical issues, and ergonomics in the context of IoP approaches. In the scope of this paper, a research approach is presented that considers these aspects from an intra-company perspective by conducting studies on the shop floor, control level and management level of companies in the production area. Focused on four central dimensions—governance, organization, capabilities, and interfaces—this contribution presents a research framework that is focused on a systematic integration and consideration of human aspects in the realization of the IoP. KW - Human factors KW - Digitalization KW - Acceptance KW - Ethics KW - Human-robot collaboration Y1 - 2020 SN - 978-3-030-51980-3 U6 - https://doi.org/10.1007/978-3-030-51981-0_1 N1 - AHFE 2020 Virtual Conferences on Human Aspects of Advanced Manufacturing, Advanced Production Management and Process Control, and Additive Manufacturing, Modeling Systems and 3D Prototyping, July 16–20, 2020, USA SP - 3 EP - 17 PB - Springer CY - Cham ER - TY - JOUR A1 - Poghossian, Arshak A1 - Jablonski, Melanie A1 - Molinnus, Denise A1 - Wege, Christina A1 - Schöning, Michael Josef T1 - Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers JF - Frontiers in Plant Science N2 - Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases. Y1 - 2020 U6 - https://doi.org/10.3389/fpls.2020.598103 VL - 11 IS - Article 598103 SP - 1 EP - 14 PB - Frontiers CY - Lausanne ER - TY - JOUR A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Capacitive field-effect eis chemical sensors and biosensors: A status report JF - Sensors N2 - Electrolyte-insulator-semiconductor (EIS) field-effect sensors belong to a new generation of electronic chips for biochemical sensing, enabling a direct electronic readout. The review gives an overview on recent advances and current trends in the research and development of chemical sensors and biosensors based on the capacitive field-effect EIS structure—the simplest field-effect device, which represents a biochemically sensitive capacitor. Fundamental concepts, physicochemical phenomena underlying the transduction mechanism and application of capacitive EIS sensors for the detection of pH, ion concentrations, and enzymatic reactions, as well as the label-free detection of charged molecules (nucleic acids, proteins, and polyelectrolytes) and nanoparticles, are presented and discussed. Y1 - 2020 U6 - https://doi.org/10.3390/s20195639 SN - 1424-8220 VL - 20 IS - 19 PB - MDPI CY - Basel ER - TY - JOUR A1 - Pogorelova, Natalia A1 - Rogachev, Evgeniy A1 - Digel, Ilya A1 - Chernigova, Svetlana A1 - Nardin, Dmitry T1 - Bacterial Cellulose Nanocomposites: Morphology and Mechanical Properties JF - Materials N2 - Bacterial cellulose (BC) is a promising material for biomedical applications due to its unique properties such as high mechanical strength and biocompatibility. This article describes the microbiological synthesis, modification, and characterization of the obtained BC-nanocomposites originating from symbiotic consortium Medusomyces gisevii. Two BC-modifications have been obtained: BC-Ag and BC-calcium phosphate (BC-Ca3(PO4)2). Structure and physicochemical properties of the BC and its modifications were investigated by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and infrared Fourier spectroscopy as well as by measurements of mechanical and water holding/absorbing capacities. Topographic analysis of the surface revealed multicomponent thick fibrils (150–160 nm in diameter and about 15 µm in length) constituted by 50–60 nm nanofibrils weaved into a left-hand helix. Distinctive features of Ca-phosphate-modified BC samples were (a) the presence of 500–700 nm entanglements and (b) inclusions of Ca3(PO4)2 crystals. The samples impregnated with Ag nanoparticles exhibited numerous roundish inclusions, about 110 nm in diameter. The boundaries between the organic and inorganic phases were very distinct in both cases. The Ag-modified samples also showed a prominent waving pattern in the packing of nanofibrils. The obtained BC gel films possessed water-holding capacity of about 62.35 g/g. However, the dried (to a constant mass) BC-films later exhibited a low water absorption capacity (3.82 g/g). It was found that decellularized BC samples had 2.4 times larger Young’s modulus and 2.2 times greater tensile strength as compared to dehydrated native BC films. We presume that this was caused by molecular compaction of the BC structure. Y1 - 2020 SN - 1996-1944 U6 - https://doi.org/10.3390/ma13122849 VL - 13 IS - 12 SP - 1 EP - 16 PB - MDPI CY - Basel ER - TY - CHAP A1 - Pohle-Fröhlich, Regina A1 - Dalitz, Christoph A1 - Richter, Charlotte A1 - Hahnen, Tobias A1 - Stäudle, Benjamin A1 - Albracht, Kirsten T1 - Estimation of muscle fascicle orientation in ultrasonic images T2 - Proceedings of the 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications - Volume 5 N2 - We compare four different algorithms for automatically estimating the muscle fascicle angle from ultrasonic images: the vesselness filter, the Radon transform, the projection profile method and the gray level cooccurence matrix (GLCM). The algorithm results are compared to ground truth data generated by three different experts on 425 image frames from two videos recorded during different types of motion. The best agreement with the ground truth data was achieved by a combination of pre-processing with a vesselness filter and measuring the angle with the projection profile method. The robustness of the estimation is increased by applying the algorithms to subregions with high gradients and performing a LOESS fit through these estimates. Y1 - 2020 SN - 978-989-758-402-2 U6 - https://doi.org/10.5220/0008933900790086 N1 - 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications VISAPP 2020, Valletta, Malta SP - 79 EP - 86 PB - SciTePress CY - Setúbal, Portugal ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Abel, Thomas A1 - Albracht, Kirsten A1 - Meskemper, Joshua A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants JF - European Journal of Applied Physiology N2 - Purpose This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise. Methods Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography. Results During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors. Conclusion Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training. Y1 - 2020 U6 - https://doi.org/10.1007/s00421-020-04373-x SN - 1439-6327 IS - 120 SP - 1403 EP - 1415 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Quittmann, Oliver J. A1 - Meskemper, Joshua A1 - Albracht, Kirsten A1 - Abel, Thomas A1 - Foitschik, Tina A1 - Strüder, Heiko K. T1 - Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs JF - Journal of Electromyography and Kinesiology N2 - Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA. Y1 - 2020 U6 - https://doi.org/10.1016/j.jelekin.2020.102402 SN - 1050-6411 VL - 51 IS - Article 102402 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Raffeis, Iris A1 - Adjei-Kyeremeh, Frank A1 - Vroomen, Uwe A1 - Westhoff, Elmar A1 - Bremen, Sebastian A1 - Hohoi, Alexandru A1 - Bührig-Polaczek, Andreas T1 - Qualification of a Ni-Cu alloy for the laser powder bed fusion process (LPBF): Its microstructure and mechanical properties JF - Applied Sciences N2 - As researchers continue to seek the expansion of the material base for additive manufacturing, there is a need to focus attention on the Ni–Cu group of alloys which conventionally has wide industrial applications. In this work, the G-NiCu30Nb casting alloy, a variant of the Monel family of alloys with Nb and high Si content is, for the first time, processed via the laser powder bed fusion process (LPBF). Being novel to the LPBF processes, optimum LPBF parameters were determined, and hardness and tensile tests were performed in as-built conditions and after heat treatment at 1000 °C. Microstructures of the as-cast and the as-built condition were compared. Highly dense samples (99.8% density) were achieved after varying hatch distance (80 µm and 140 µm) with scanning speed (550 mm/s–1500 mm/s). There was no significant difference in microhardness between varied hatch distance print sets. Microhardness of the as-built condition (247 HV0.2) exceeded the as-cast microhardness (179 HV0.2.). Tensile specimens built in vertical (V) and horizontal (H) orientations revealed degrees of anisotropy and were superior to conventionally reported figures. Post heat treatment increased ductility from 20% to 31% (V), as well as from 16% to 25% (H), while ultimate tensile strength (UTS) and yield strength (YS) were considerably reduced. Y1 - 2020 U6 - https://doi.org/10.3390/app10103401 SN - 2076-3417 N1 - Special Issue Materials Development by Additive Manufacturing Techniques VL - 10 IS - Art. 3401 SP - 1 EP - 15 PB - MDPI CY - Basel ER - TY - JOUR A1 - Ramoshaba, Nthai E. A1 - Huisman, Hugo W. A1 - Lammertyn, Leandi A1 - Kotliar, Konstantin A1 - Schutte, Aletta E. A1 - Smith, Wayne T1 - Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study JF - Hypertension Research N2 - Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20–30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = −0.097 (95% CI = −0.165; −0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life. Y1 - 2020 U6 - https://doi.org/10.1038/s41440-020-0487-0 SN - 1348-4214 IS - 43 SP - 1231 EP - 1238 PB - Springer Nature CY - Osaka ER - TY - JOUR A1 - Rausch, Valentin A1 - Harbrecht, Andreas A1 - Kahmann, Stephanie Lucina A1 - Fenten, Thomas A1 - Jovanovic, Nebojsa A1 - Hackl, Michael A1 - Müller, Lars P. A1 - Staat, Manfred A1 - Wegmann, Kilian T1 - Osteosynthesis of Phalangeal Fractures: Biomechanical Comparison of Kirschner Wires, Plates, and Compression Screws JF - The Journal of Hand Surgery N2 - Purpose The aim of this study was to compare several osteosynthesis techniques (intramedullary headless compression screws, T-plates, and Kirschner wires) for distal epiphyseal fractures of proximal phalanges in a human cadaveric model. Methods A total of 90 proximal phalanges from 30 specimens (index, ring, and middle fingers) were used for this study. After stripping off all soft tissue, a transverse distal epiphyseal fracture was simulated at the proximal phalanx. The 30 specimens were randomly assigned to 1 fixation technique (30 per technique), either a 3.0-mm intramedullary headless compression screw, locking plate fixation with a 2.0-mm T-plate, or 2 oblique 1.0-mm Kirschner wires. Displacement analysis (bending, distraction, and torsion) was performed using optical tracking of an applied random speckle pattern after osteosynthesis. Biomechanical testing was performed with increasing cyclic loading and with cyclic load to failure using a biaxial torsion-tension testing machine. Results Cannulated intramedullary compression screws showed significantly less displacement at the fracture site in torsional testing. Furthermore, screws were significantly more stable in bending testing. Kirschner wires were significantly less stable than plating or screw fixation in any cyclic load to failure test setup. Conclusions Intramedullary compression screws are a highly stable alternative in the treatment of transverse distal epiphyseal phalangeal fractures. Kirschner wires seem to be inferior regarding displacement properties and primary stability. Clinical relevance Fracture fixation of phalangeal fractures using plate osteosynthesis may have the advantage of a very rigid reduction, but disadvantages such as stiffness owing to the more invasive surgical approach and soft tissue irritation should be taken into account. Headless compression screws represent a minimally invasive choice for fixation with good biomechanical properties. Y1 - 2020 U6 - https://doi.org/10.1016/j.jhsa.2020.04.010 SN - 0363-5023 VL - 45 IS - 10 SP - 987.e1 EP - 987.e8 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rausch, Valentin A1 - Kahmann, Stephanie Lucina A1 - Baltschun, Christoph A1 - Staat, Manfred A1 - Müller, Lars P. A1 - Wegmann, Kilian T1 - Pressure distribution to the distal biceps tendon at the radial tuberosity: a biomechanical study JF - The Journal of Hand Surgery N2 - Purpose Mechanical impingement at the narrow radioulnar space of the tuberosity is believed to be an etiological factor in the injury of the distal biceps tendon. The aim of the study was to compare the pressure distribution at the proximal radioulnar space between 2 fixation techniques and the intact state. Methods Six right arms and 6 left arms from 5 female and 6 male frozen specimens were used for this study. A pressure transducer was introduced at the height of the radial tuberosity with the intact distal biceps tendon and after 2 fixation methods: the suture-anchor and the cortical button technique. The force (N), maximum pressure (kPa) applied to the radial tuberosity, and the contact area (mm²) of the radial tuberosity with the ulna were measured and differences from the intact tendon were detected from 60° supination to 60° pronation in 15° increments with the elbow in full extension and in 45° and 90° flexion of the elbow. Results With the distal biceps tendon intact, the pressures during pronation were similar regardless of extension and flexion and were the highest at 60° pronation with 90° elbow flexion (23.3 ± 53.5 kPa). After repair of the tendon, the mean peak pressure, contact area, and total force showed an increase regardless of the fixation technique. Highest peak pressures were found using the cortical button technique at 45° flexion of the elbow and 60° pronation. These differences were significantly different from the intact tendon. The contact area was significantly larger in full extension and 15°, 30°, and 60° pronation using the cortical button technique. Conclusions Pressures on the distal biceps tendon at the radial tuberosity increase during pronation, especially after repair of the tendon. Clinical relevance Mechanical impingement could play a role in both the etiology of primary distal biceps tendon ruptures and the complications occurring after fixation of the tendon using certain techniques. Y1 - 2020 U6 - https://doi.org/10.1016/j.jhsa.2020.01.006 SN - 0363-5023 VL - 45 IS - 8 SP - 776.e1 EP - 776.e9 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Reger, Vitali A1 - Kuhnhenne, Markus A1 - Ebbert, Thiemo A1 - Hachul, Helmut A1 - Blanke, Tobias A1 - Döring, Bernd T1 - Nutzung erneuerbarer Energien durch thermische Aktivierung von Komponenten aus Stahl JF - Stahlbau N2 - Die Versorgung von Neubauten soll möglichst weitgehend unabhängig von fossilen Energieträgern erfolgen. Erneuerbare Energien spielen dafür eine gewichtige Rolle. Eine gute Möglichkeit, erneuerbare Energien ohne viel zusätzlichen Aufwand nutzbar zu machen, ist, bereits vorhandenen Komponenten im Gebäude zusätzliche Funktionen zu geben. Hier kann bspw. die Fassade oder das Dach solarthermisch aktiviert oder durch Fotovoltaikmodule ergänzt werden. Auch Tiefgründungen können neben der statischen Funktion noch eine geothermische Funktion zur Aufnahme oder Abgabe von Wärme erhalten. Neben der Erzeugung bietet sich auch für die Verteilung der Wärme oder Kälte im Gebäude die Integration in Bauteile an. Hier kann bspw. der Boden durch eine Fußbodenheizung oder die Decke durch Deckenstrahlplatten aktiviert werden. Im Rahmen der Veröffentlichung wird auf die thermische Aktivierung von Stahlkomponenten eingegangen. Es wird eine Lösung vorgestellt, die vorgehängte hinterlüftete Stahlfassade (VHF) solarthermisch zu aktivieren. Außerdem werden zwei Möglichkeiten zur geothermischen Aktivierung von Tiefgründungen mittels Stahlpfählen gezeigt. Zuletzt wird ein System zur thermischen Aktivierung von Stahltrapezprofilen an der Decke erläutert, welches Wärme zuführen oder bei Bedarf abführen kann. Y1 - 2020 U6 - https://doi.org/10.1002/stab.202000031 SN - 1437-1049 VL - 2020 IS - Volume 89, Issue 6512-519 SP - 512 EP - 519 PB - Ernst & Sohn CY - Berlin ER - TY - CHAP A1 - Reke, Michael A1 - Peter, Daniel A1 - Schulte-Tigges, Joschua A1 - Schiffer, Stefan A1 - Ferrein, Alexander A1 - Walter, Thomas A1 - Matheis, Dominik T1 - A Self-Driving Car Architecture in ROS2 T2 - 2020 International SAUPEC/RobMech/PRASA Conference, Cape Town, South Africa N2 - In this paper we report on an architecture for a self-driving car that is based on ROS2. Self-driving cars have to take decisions based on their sensory input in real-time, providing high reliability with a strong demand in functional safety. In principle, self-driving cars are robots. However, typical robot software, in general, and the previous version of the Robot Operating System (ROS), in particular, does not always meet these requirements. With the successor ROS2 the situation has changed and it might be considered as a solution for automated and autonomous driving. Existing robotic software based on ROS was not ready for safety critical applications like self-driving cars. We propose an architecture for using ROS2 for a self-driving car that enables safe and reliable real-time behaviour, but keeping the advantages of ROS such as a distributed architecture and standardised message types. First experiments with an automated real passenger car at lower and higher speed-levels show that our approach seems feasible for autonomous driving under the necessary real-time conditions. Y1 - 2020 SN - 978-1-7281-4162-6 U6 - https://doi.org/10.1109/SAUPEC/RobMech/PRASA48453.2020.9041020 N1 - 2020 International SAUPEC/RobMech/PRASA Conference, 29-31 Jan. 2020, Cape Town, South Africa SP - 1 EP - 6 PB - IEEE CY - New York, NY ER -