TY  - JOUR
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Simonis, A.
A1  - Ecken, H.
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS?
JF  - Sensors and Actuators B. 78 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 237
EP  - 242
ER  - 
TY  - JOUR
A1  - Rolka, David
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Integration of a capacitive EIS sensor into a FIA system for pH and penicillin determination
JF  - Sensors. 4 (2004)
Y1  - 2004
SN  - 1424-8220
SP  - 84
EP  - 94
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Krischer, M.
A1  - Wenzel, L.
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor
JF  - Procedia Engineering
N2  - A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.
KW  - Field-effect sensor
KW  - enzymatic (bio)degradation
KW  - poly(d, l-lactic acid)
KW  - in-situ monitoring
KW  - impedance spectroscopy
Y1  - 2014
U6  - http://dx.doi.org/10.1016/j.proeng.2014.11.689
SN  - 1877-7058
N1  - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014>
VL  - 87
SP  - 1314
EP  - 1317
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Leinhos, Marcel
A1  - Krischer, M.
A1  - Wenzel, L.
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Sensorkonzept zur in vitro Echtzeitmessung des Degradationsverhaltens von biodegradierbaren Biopolymeren
T2  - 11. Dresdner Sensor-Symposium : 9.-11.12.2013
Y1  - 2013
SN  - 978-3-9813484-5-3
SP  - 174
EP  - 177
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Krischer, M.
A1  - Molin, D. G. M.
A1  - Akker, N. M. S. van den
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Sensor System for in-situ and Real-time Monitoring of Polymer (bio) degradation
JF  - Procedia Engineering
N2  - A sensor system for investigating (bio)degradationprocesses of polymers is presented. The system utilizes semiconductor field-effect sensors and is capable of monitoring the degradation process in-situ and in real-time. The degradation of the polymer poly(d,l-lactic acid) is exemplarily monitored in solutions with different pH value, pH-buffer solution containing the model enzyme lipase from Rhizomucormiehei and cell-culture medium containing supernatants from stimulated and non-stimulated THP-1-derived macrophages mimicking activation of the immune system.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.815
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 948
EP  - 951
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Krischer, Maximillian
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors
JF  - Analytical Chemistry
N2  - Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(d,l-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers.
Y1  - 2015
U6  - http://dx.doi.org/10.1021/acs.analchem.5b00617
SN  - 1520-6882
VL  - 87
IS  - 13
SP  - 6607
EP  - 6613
PB  - ACS Publications
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers
JF  - Physica Status Solidi (A)
N2  - Investigation of the degradation kinetics of biodegradable polymers is essential for the development of implantable biomedical devices with predicted biodegradability. In this work, an impedimetric sensor has been applied for real-time and in situ monitoring of degradation processes of biopolymers. The sensor consists of two platinum thin-film electrodes covered by a polymer film to be studied. The benchmark biomedical polymer poly(D,L-lactic acid) (PDLLA) was used as a model system. PDLLA films were deposited on the sensor structure from a polymer solution by using the spin-coating method. The degradation kinetics of PDLLA films have been studied in alkaline solutions of pH 9 and 12 by means of an impedance spectroscopy (IS) method. Any changes in a polymer capacitance/resistance induced by water uptake and/or polymer degradation will modulate the global impedance of the polymer-covered sensor that can be used as an indicator of the polymer degradation. The degradation rate can be evaluated from the time-dependent impedance spectra. As expected, a faster degradation has been observed for PDLLA films exposed to pH 12 solution.
Y1  - 2013
U6  - http://dx.doi.org/10.1002/pssa.201200941
SN  - 1521-396X ; 0031-8965
VL  - 210
IS  - 5
SP  - 905
EP  - 910
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Schusser, Sebastian
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
ED  - Abdelghani, Adnane
ED  - Schöning, Michael Josef
T1  - Biopolymer-degradation monitoring by chip-­based impedance spectroscopy technique
T2  - Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012
Y1  - 2012
SP  - 47
EP  - 47
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Menzel, S.
A1  - Bäcker, Matthias
A1  - Leinhos, Marcel
A1  - Poghossian, Arshak
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Degradation of thin poly(lactic acid) films: characterization by capacitance-voltage, atomic force microscopy, scanning electron microscopy and contact-angle measurements
JF  - Electrochimica Acta
Y1  - 2013
SN  - 1873-3859 (E-Journal); 0013-4686 (Print)
VL  - Vol. 113
SP  - 779
EP  - 784
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Krischer, M.
A1  - Leinhos, Marcel
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - An application of field-effect sensors for in-situ monitoring of degradation of biopolymers
JF  - Sensors and actuators B: Chemical
N2  - The characterization of the degradation kinetics of biodegradable polymers is mandatory with regard to their proper application. In the present work, polymer-modified electrolyte–insulator–semiconductor (PMEIS) field-effect sensors have been applied for in-situ monitoring of the pH-dependent degradation kinetics of the commercially available biopolymer poly(d,l-lactic acid) (PDLLA) in buffer solutions from pH 3 to pH 13. PDLLA films of 500 nm thickness were deposited on the surface of an Al–p-Si–SiO2–Ta2O5 structure from a polymer solution by means of spin-coating method. The PMEIS sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. A faster degradation has been observed for PDLLA films exposed to alkaline solutions (pH 9, pH 11 and pH 13).
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.snb.2014.10.058
SN  - 1873-3077 (E-Journal); 0925-4005 (Print)
VL  - 207, Part B
SP  - 954
EP  - 959
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schusser, Sebastian
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Leinhos, Marcel
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Characterization of biodegradable polymers with capacitive field-effect sensors
JF  - Sensors and actuators B: Chemical
N2  - In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.
KW  - Impedance spectroscopy
KW  - C–V method
KW  - Real-time monitoring
KW  - Poly(d,l-lacticacid)
KW  - (Bio)degradation
KW  - Field-effect sensor
Y1  - 2012
U6  - http://dx.doi.org/10.1016/j.snb.2012.07.099
SN  - 0925-4005
N1  - Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors"
VL  - 187
SP  - 2
EP  - 7
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Han, Y.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Poghossian, Arshak
T1  - Markierungsfreie DNA-Detektion mit Silizium-Feldeffektsensoren – Messeffekte oder Artefakte?
T2  - Sensoren und Mess-Systeme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau
Y1  - 2006
SN  - 3-8007-2939-3
SP  - 443
EP  - 446
PB  - VDE Verl.
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Ingebrandt, Sven
A1  - Platen, Johannes
A1  - Offenhäusser, Andreas
A1  - Poghossian, Arshak
ED  - Comini, Elisabetta
T1  - Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices
JF  - Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.
Y1  - 2006
SN  - 9781558998711
IS  - paper 0915-R05-04
SP  - 89
EP  - 94
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
T1  - pH and ion sensitivity of a field-effect EIS (electrolyte-insulator-semiconductor) sensor covered with polyelectrolyte multilayers
JF  - Journal of Solid State Electrochemistry. 13 (2009), H. 1
Y1  - 2009
SN  - 1433-0768
N1  - This manuscript is an invited paper to the special issue on “Solid-state potentiometric sensors” (Guest editor: Johan Bobacka).
SP  - 115
EP  - 122
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Han, Yinhua
A1  - Offenhäusser, Andreas
A1  - Ingebrandt, Sven
T1  - Markierungsfreie DNA-Detektion mit Silizium-Feldeffekt-Sensoren – Messeffekte oder Artefakte?
JF  - tm - Technisches Messen . 74 (2007), H. 9
Y1  - 2007
SN  - 0171-8096
SP  - 466
EP  - 476
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Abouzar, Maryam H.
A1  - Wagner, Torsten
A1  - Näther, Niko
A1  - Rolka, David
A1  - Yoshinobu, Tatsuo
A1  - Kloock, Joachim P.
A1  - Turek, Monika
A1  - Ingebrandt, Sven
A1  - Poghossian, Arshak
T1  - A semiconductor-based field-effect platform for (bio-)chemical and physical sensors: From capacitive EIS sensors and LAPS over ISFETs to nano-scale devices
T2  - MRS Proceedings
Y1  - 2006
U6  - http://dx.doi.org/10.1557/PROC-0952-F08-02
N1  - Vol. 952 - Symposium F - Integrated Nanosensors
SP  - 1
EP  - 9
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Biselli, Manfred
A1  - Selmer, Thorsten
A1  - Öhlschläger, Peter
A1  - Baumann, Marcus
A1  - Förster, Arnold
A1  - Poghossian, Arshak
T1  - Forschung „zwischen“ den Disziplinen: das Institut für Nano- und Biotechnologien
JF  - Analytik news : das Online-Labormagazin für Labor und Analytik
N2  - "Biologie trifft Mikroelektronik", das Motto des Instituts für Nano- und Biotechnologien (INB) an der FH Aachen, unterstreicht die zunehmende Bedeutung interdisziplinär geprägter Forschungsaktivitäten. Der thematische Zusammenschluss grundständiger Disziplinen, wie die Physik, Elektrotechnik, Chemie, Biologie sowie die Materialwissenschaften, lässt neue Forschungsgebiete entstehen, ein herausragendes Beispiel hierfür ist die Nanotechnologie: Hier werden neue Werkstoffe und Materialien entwickelt, einzelne Nanopartikel oder Moleküle und deren Wechselwirkung untersucht oder Schichtstrukturen im Nanometerbereich aufgebaut, die neue und vorher nicht bekannte Eigenschaften hervorbringen.

Vor diesem Hintergrund bündelt das im Jahre 2006 gegründete INB die an der FH Aachen vorhandenen Kompetenzen von derzeit insgesamt sieben Laboratorien auf den Gebieten der Halbleitertechnik und Nanoelektronik, Nanostrukturen und DNA-Sensorik, der Chemo- und Biosensorik, der Enzymtechnologie, der Mikrobiologie und Pflanzenbiotechnologie, der Zellkulturtechnik, sowie der Roten Biotechnologie synergetisch. In der Nano- und Biotechnologie steckt außergewöhnliches Potenzial! Nicht zuletzt deshalb stellen sich die Forscher der Herausforderung, in diesem Bereich gemeinsam zu forschen und Schnittstellen zu nutzen, um so bei der Gestaltung neuartiger Ideen und Produkte mitzuwirken, die zukünftig unser alltägliches Leben verändern werden.

Im Folgenden werden die verschiedenen Forschungsbereiche kurz zusammenfassend vorgestellt und vorhandene Interaktionen anhand von exemplarisch ausgewählten, aktuellen Forschungsprojekten skizziert.
Y1  - 2012
VL  - Publ. online
PB  - Dr. Beyer Internet-Beratung
CY  - Ober-Ramstadt
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Brinkmann, D.
A1  - Demuth, C.
A1  - Poghossian, Arshak
T1  - CIP (cleaning-in-place)-suitable „non-glass“ pH sensor based on a Ta2O5-gate EIS structure
JF  - Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].
Y1  - 2004
SN  - 88-7621-282-5
N1  - Eurosensors ; (18, 2004, Roma)
SP  - 857
EP  - 860
CY  - Roma
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Brinkmann, D.
A1  - Rolka, David
A1  - Demuth, C.
A1  - Poghossian, Arshak
T1  - CIP (cleaning-in-place) suitable “non-glass” pH sensor based on a Ta2O5-gate EIS structure
JF  - Sensors and Actuators B: Chemical. 111-112 (2005)
Y1  - 2005
SN  - 0925-4005
N1  - Eurosensors XVIII 2004 - The 18th European Conference on Solid-State Transducers
SP  - 423
EP  - 429
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Bronder, Thomas
A1  - Wu, Chunsheng
A1  - Scheja, Sabrina
A1  - Jessing, Max
A1  - Metzger-Boddien, Christoph
A1  - Keusgen, Michael
A1  - Poghossian, Arshak
T1  - Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities
JF  - Proceedings
N2  - Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1080719
SN  - 2504-3900
N1  - This article belongs to the Proceedings of "Proceedings of the 5th International Symposium on Sensor Science (I3S 2017)"
VL  - 1
IS  - 8
SP  - Artikel 719
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Näther, Niko
A1  - Auger, V.
A1  - Poghossian, Arshak
A1  - Koudelka-Hep, M.
T1  - Miniaturised flow-through cell with integrated capacitive EIS sensor fabricated at wafer level using Si and SU-8 technologies
JF  - Sensors and Actuators B. 108 (2005), H. 1-2
Y1  - 2005
SN  - 0925-4005
N1  - Proceedings of the Tenth International Meeting on Chemical Sensors — IMCS - 10 2004
SP  - 986
EP  - 992
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Näther, Niko
A1  - Auger, V.
A1  - Poghossian, Arshak
A1  - Koudelka-Hep, M.
T1  - Miniaturized flow-through cell with integrated capacitive EIS sensors fabricated at wafer level using Si and Su-8 technologies
JF  - Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors
Y1  - 2004
N1  - Chemical sensors ; 20.2004 Suppl. B. IMCS ; (10, 2004, Tsukuba) ; International Meeting on Chemical Sensors ; (10 : ; 2004.07.11-14 : ; Tsukuba)
SP  - 554
EP  - 555
PB  - Japan Association of Chemical Sensors
CY  - Fukuoka
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Recent advances in biologically sensitive field-effect transistors (BioFETs)
JF  - Analyst. 127 (2002)
Y1  - 2002
SN  - 0003-2654
SP  - 1137
EP  - 1151
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Detection of charged macromolecules by means of field-effect devices (FEDs): possibilities and limitations
JF  - Electrochemical sensors, biosensors and their biomedical applications / ed. by Xueji Zhang ...
Y1  - 2008
SN  - 978-0-12-373738-0
SP  - 187
EP  - 212
PB  - Elsevier Acad. Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Silicon-based field-effect devices for (bio-)chemical sensing
JF  - International Conference on Advanced Semiconductor Devices and Microsystems, 2008. ASDAM 2008
Y1  - 2008
SN  - 978-1-4244-2325-5
SP  - 31
EP  - 38
CY  - Smolenice, Slovakia
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Silicon-based field-effect devices with nanostructured surfaces for bio-/chemical sensing
JF  - Semiconductor micro- and nanoelectronics : Proceedings of the Seventh International Conference , Tsakhcadzor, Armenia July 3-5 2009
Y1  - 2009
SP  - 51
EP  - 53
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - BioFEDs (field-effect devices) : State-of-the-art and new directions
JF  - Electroanalysis
Y1  - 2006
U6  - http://dx.doi.org/10.1002/elan.200603609
SN  - 1521-4109
VL  - 18
IS  - 19-20
SP  - 1893
EP  - 1900
ER  - 
TY  - BOOK
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Label-free biosensing: advanced materials, devices and applications
Y1  - 2018
SN  - 978-3-319-75219-8
PB  - Springer
CY  - Cham
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
T1  - Enzyme und Biosensorik
T2  - Einführung in die Enzymtechnologie
N2  - Enzymbasierte Biosensoren finden seit mehr als fünf Jahrzehnten einen prosperierenden Wachstumsmarkt und werden zunehmend auch in biotechnologischen Prozessen eingesetzt. In diesem Kapitel werden, ausgehend vom Sensorbegriff und typischen Kenngrößen für Biosensoren (Abschn. 18.1), elektrochemische Enzym-Biosensoren vorgestellt und deren typischen Einsatzgebiete diskutiert (Abschn. 18.2). Ein Blick über den „Tellerrand“ hinaus zeigt alternative Transduktorprinzipien (Abschn. 18.3) und führt abschließend in aktuelle Forschungstrends ein (Abschn. 18.4).
Y1  - 2018
SN  - 978-3-662-57619-9
U6  - http://dx.doi.org/10.1007/978-3-662-57619-9_18
SP  - 323
EP  - 347
PB  - Springer Spektrum
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Glück, Olaf
A1  - Thust, Marion
T1  - Electrochemical composition measurement
T2  - Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen
Y1  - 2014
SN  - 978-1-4398-4891-3
SP  - 55-1
EP  - 55-54
PB  - CRC Pr.
CY  - Boca Raton, Fa.
ET  - 2nd ed.
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Glück, Olaf
A1  - Thust, Marion
T1  - Electrochemical methods for the determination of chemical variables in aqueous media
T2  - Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement
Y1  - 2014
SN  - 978-1-4398-4891-3
SP  - 55-1
EP  - 55-54
PB  - CRC Pr.
CY  - Boca Raton, Fla.
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Schultze, J. W.
A1  - Lüth, H.
T1  - Field-effect based multifunctional hybrid sensor module for the determination of both (bio-)chemical and physical paramters
JF  - Proceedings of SPIE. 4576 (2002)
Y1  - 2002
SP  - 149
EP  - 159
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Schultze, Joachim W.
T1  - Measuring seven parameters by two ISFET modules in a microcell set-up
JF  - Int. Journal of Computational Engineering Science. 4 (2003), H. 2
Y1  - 2003
SN  - 1465-8763
SP  - 257
EP  - 260
ER  - 
TY  - JOUR
A1  - Schöning, Michael Josef
A1  - Poghossian, Arshak
A1  - Yoshinobu, Tatsuo
A1  - Lüth, Hans
T1  - Semiconductor-based field-effect structures for chemical sensing
Y1  - 2001
SP  - 188
EP  - 198
ER  - 
TY  - CHAP
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
A1  - Poghossian, Arshak
A1  - Miyamoto, K.I.
A1  - Werner, C.F.
A1  - Krause, S.
A1  - Yoshinobu, T.
T1  - Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging
T2  - Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7
Y1  - 2018
SN  - 9780128097397
SP  - 295
EP  - 308
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Maki, Rafael M.
A1  - Paulovich, Fernando V.
A1  - Werner, Frederik
A1  - Poghossian, Arshak
A1  - Oliveira, Maria C. F. de
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor
JF  - Analytical Chemistry  (2010)
Y1  - 2010
SN  - 0003-2700
SP  - 61
EP  - 65
ER  - 
TY  - JOUR
A1  - Siqueira, Jose R.
A1  - Werner, Frederik
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Layer-by-Layer Assembly of Carbon Nanotubes Incorporated in Light-Addressable Potentiometric Sensors
JF  - Journal of Physical Chemistry C. 113 (2009), H. 33
Y1  - 2009
SN  - 1932-7455
SP  - 14765
EP  - 14770
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Bäcker, Matthias
A1  - Zucolotto, Valtencir
A1  - Poghossian, Arshak
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors
JF  - physica status solidi (a) . 206 (2009), H. 3
Y1  - 2009
SN  - 1862-6319
N1  - Special Issue: Engineering of Functional Interfaces (EnFI 08)
SP  - 462
EP  - 467
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Abouzar, Maryam H.
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer
JF  - Biosensors and Bioelectronics. 25 (2009), H. 2
Y1  - 2009
SN  - 0956-5663
SP  - 497
EP  - 501
ER  - 
TY  - JOUR
A1  - Siqueira, José R. Jr.
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Zucolotto, Valtencir
A1  - Oliveira, Osvaldo N. Jr.
A1  - Schöning, Michael Josef
T1  - Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices
JF  - Physica status solidi (a). 207 (2010), H. 4
Y1  - 2010
SN  - 1862-6300
N1  - Special Issue: Engineering of Functional Interfaces EnFI 2009
SP  - 781
EP  - 786
ER  - 
TY  - JOUR
A1  - Spelthahn, Heiko
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Self-aligned nanogaps and nanochannels via conventional photolithography and pattern-size reduction technique
JF  - Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI
Y1  - 2009
SN  - 0013-4686
SP  - 6010
EP  - 6014
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Naser, S.
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Crosssensitivity of a capacitive penicillin sensor combined with a diffusion barrier
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors ; (13, 1999, 's-Gravenhage) ; Eurosensors ; (13 : ; 1999.09.12-15 : ; The Hague) ; European Conference on Solid-State Transducers ; (13 : ; 1999.09.12-15 : ; The Hague)
SP  - 573
EP  - 576
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Thust, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Naser, S.
A1  - Müller-Veggian, Mattea
A1  - Kordos, P.
A1  - Lüth, H.
T1  - Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier
JF  - Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1.
Y1  - 1999
SN  - 90-76699-02-X
N1  - Eurosensors <13, 1999, 's-Gravenhage> ; Eurosensors <13, 1999, The Hague> ;  European Conference on Solid-State Transducers <13, 1999, The Hague>
SP  - 573
EP  - 576
CY  - The Hague, The Netherlands
ER  - 
TY  - JOUR
A1  - Turek, M.
A1  - Keusgen, M.
A1  - Poghossian, Arshak
A1  - Mulchandani, A.
A1  - Wang, J.
A1  - Schöning, Michael Josef
T1  - Enzyme-modified electrolyte-insulator-semiconductor sensors
JF  - Journal of Contemporary Physics. 43 (2008), H. 2
Y1  - 2008
SN  - 1934-9378
N1  - Armenian Academy of Sciences
SP  - 82
EP  - 85
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Beging, Stefan
A1  - Rotter, L.
A1  - Poghossian, Arshak
A1  - Biselli, Manfred
A1  - Zang, Werner
A1  - Schöning, Michael Josef
T1  - Online-Messsysteme für die automatisierte Charakterisierung von feldeffektbasierten Biosensoren
JF  - 8. Dresdner Sensor-Symposium : Sensoren für Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme für die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung für die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)
Y1  - 2007
SN  - 978-3-940046-45-1
N1  - Dresdner Sensor-Symposium <8, 2007, Dresden> ; Dresdner Beiträge zur Sensorik ; 29
SP  - 257
EP  - 260
PB  - TUDpress, Verl. der Wissenschaften
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Wagner, Torsten
A1  - Maris, Rob J.
A1  - Ackermann, Hans-Josef
A1  - Otto, Ralph
A1  - Beging, Stefan
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations
JF  - Sensors and Actuators B: Chemical  . 127 (2007), H. 1
Y1  - 2007
SN  - 0925-4005
SP  - 217
EP  - 223
ER  - 
TY  - CHAP
A1  - Weil, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Cherstvy, A.
T1  - Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - http://dx.doi.org/10.5162/IMCS2012/P2.5.2
SP  - 1575
EP  - 1578
ER  - 
TY  - JOUR
A1  - Welden, Melanie
A1  - Poghossian, Arshak
A1  - Vahidpour, Farnoosh
A1  - Wendlandt, Tim
A1  - Keusgen, Michael
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers
JF  - Biosensors
N2  - Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1–3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.
KW  - urease
KW  - enzyme-logic gate
KW  - bi-enzyme biosensor
KW  - capacitive field-effect sensor
KW  - tobacco mosaic virus (TMV)
KW  - penicillinase
Y1  - 2022
U6  - http://dx.doi.org/10.3390/bios12010043
SN  - 2079-6374
N1  - This article belongs to the Special Issue "Biosensors: 10th Anniversary Feature Papers"
VL  - 12
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Welden, Melanie
A1  - Severins, Robin
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Bongaerts, Johannes
A1  - Siegert, Petra
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor
JF  - Chemosensors
N2  - Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte–insulator–semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin–streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage–current, capacitance–voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.
Y1  - 2022
U6  - http://dx.doi.org/10.3390/chemosensors10060218
SN  - 2227-9040
N1  - This article belongs to the Special Issue "Nanostructured Devices for Biochemical Sensing"
VL  - 10
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Welden, Melanie
A1  - Severins, Robin
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Siegert, Petra
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors
T2  - 2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN)
N2  - A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy.
KW  - Tobacco mosaic virus
KW  - acetoin
KW  - capacitive field-effect biosensor
KW  - enzyme immobilization
Y1  - 2022
SN  - 978-1-6654-5860-3 (Online)
SN  - 978-1-6654-5861-0 (Print)
U6  - http://dx.doi.org/10.1109/ISOEN54820.2022.9789657
N1  - IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 29 May 2022 - 01 June 2022, Aveiro, Portugal.
PB  - IEEE
ER  -