TY  - CHAP
A1  - Koch, Claudia
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Schöning, Michael Josef
ED  - Wege, Christina
T1  - TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications
T2  - Virus-Derived Nanoparticles for Advanced Technologies
N2  - Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance.
KW  - Tobacco mosaic virus (TMV)
KW  - Coat protein
KW  - Enzyme nanocarrier
KW  - Glucose biosensor
KW  - Glucose oxidase
Y1  - 2018
SN  - 978-1-4939-7808-3
U6  - http://dx.doi.org/10.1007/978-1-4939-7808-3
N1  - Methods in Molecular Biology, vol 1776
SP  - 553
EP  - 568
PB  - Humana Press
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Kramer, Friederike
A1  - Halamkova, Lenka
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
A1  - Halamek, Jan
T1  - Biocatalytic analysis of biomarkers for forensic identification of ethnicity between Caucasian and African American
JF  - The analyst. August 2013
Y1  - 2013
SN  - 1364-5528 (E-Journal); 0003-2654 (Print)
VL  - Vol. 138
SP  - 6251
EP  - 6257
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Krämer, Melina
A1  - Pita, Marcos
A1  - Zhou, Jian
A1  - Ornatska, Maryna
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information
JF  - Journal of Physical Chemistry C: Nanomaterials and Interfaces. 113 (2009), H. 6
Y1  - 2009
SN  - 1932-7455
SP  - 2573
EP  - 2579
PB  - American Cemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Leinhos, Marcel
A1  - Schusser, Sebastian
A1  - Bäcker, Matthias
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Micromachined multi-parameter sensor chip for the control of polymer-degradation medium
JF  - Physica Status Solidi (A) : special issue on engineering and functional interfaces
N2  - It is well known that the degradation environment can strongly influence the biodegradability and kinetics of biodegradation processes of polymers. Therefore, besides the monitoring of the degradation process, it is also necessary to control the medium in which the degradation takes place. In this work, a micromachined multi-parameter sensor chip for the control of the polymer-degradation medium has been developed. The chip combines a capacitive field-effect pH sensor, a four-electrode electrolyte-conductivity sensor and a thin-film Pt-temperature sensor. The results of characterization of individual sensors are presented. In addition, the multi-parameter sensor chip together with an impedimetric polymer-degradation sensor was simultaneously characterized in degradation solutions with different pH and electrolyte conductivity. The obtained results demonstrate the feasibility of the multi-parameter sensor chip for the control of the polymer-degradation medium.
Y1  - 2014
U6  - http://dx.doi.org/10.1002/pssa.201330364
SN  - 1521-396X (E-Journal); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)
VL  - 211
IS  - 6
SP  - 1346
EP  - 1351
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Bäcker, Matthias
A1  - Iken, Heiko
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Concept for a biomolecular logic chip with an integrated sensor and actuator function
JF  - Physica status solidi (a)
N2  - A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented.
Y1  - 2015
U6  - http://dx.doi.org/10.1002/pssa.201431913
SN  - 1862-6319
VL  - 212
IS  - 6
SP  - 1382
EP  - 1388
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Bäcker, Matthias
A1  - Siegert, Petra
A1  - Willenberg, H.
A1  - Poghossian, Arshak
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline Based on Substrate Recycling Amplification
JF  - Procedia Engineering
N2  - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.
Y1  - 2015
U6  - http://dx.doi.org/10.1016/j.proeng.2015.08.708
SN  - 1877-7058
N1  - Eurosensors 2015
VL  - 120
SP  - 540
EP  - 543
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Hardt, G.
A1  - Käver, L.
A1  - Willenberg, H.S.
A1  - Kröger, J.-C.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling
JF  - Sensor and Actuators B: Chemical
N2  - A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.snb.2018.05.136
SN  - 0925-4005
VL  - 272
SP  - 21
EP  - 27
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Molinnus, Denise
A1  - Hardt, Gabriel
A1  - Käver, Larissa
A1  - Willenberg, Holger S.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology
T2  - MDPI Proceedings
Y1  - 2017
U6  - http://dx.doi.org/10.3390/proceedings1040506
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Hardt, Gabriel
A1  - Siegert, Petra
A1  - Willenberg, Holger S.
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of Adrenaline in Blood Plasma as Biomarker for Adrenal Venous Sampling
JF  - Electroanalysis
N2  - An amperometric bi-enzyme biosensor based on substrate recycling principle for the amplification of the sensor signal has been developed for the detection of adrenaline in blood. Adrenaline can be used as biomarker verifying successful adrenal venous sampling procedure. The adrenaline biosensor has been realized via modification of a galvanic oxygen sensor with a bi-enzyme membrane combining a genetically modified laccase and a pyrroloquinoline quinone-dependent glucose dehydrogenase. The measurement conditions such as pH value and temperature were optimized to enhance the sensor performance. A high sensitivity and a low detection limit of about 0.5–1 nM adrenaline have been achieved in phosphate buffer at pH 7.4, relevant for measurements in blood samples. The sensitivity of the biosensor to other catecholamines such as noradrenaline, dopamine and dobutamine has been studied. Finally, the sensor has been successfully applied for the detection of adrenaline in human blood plasma.
Y1  - 2018
U6  - http://dx.doi.org/10.1002/elan.201800026
SN  - 1521-4109
VL  - 30
IS  - 5
SP  - 937
EP  - 942
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Iken, Heiko
A1  - Johnen, Anna Lynn
A1  - Richstein, Benjamin
A1  - Hellmich, Lena
A1  - Poghossian, Arshak
A1  - Knoch, Joachim
A1  - Schöning, Michael Josef
T1  - Miniaturized pH-Sensitive Field-Effect Capacitors with Ultrathin Ta₂O₅ Films Prepared by Atomic Layer Deposition
JF  - physica status solidi (a) applications and materials science
N2  - Miniaturized electrolyte–insulator–semiconductor capacitors (EISCAPs) with ultrathin gate insulators have been studied in terms of their pH-sensitive sensor characteristics: three different EISCAP systems consisting of Al–p-Si–Ta2O5(5 nm), Al–p-Si–Si3N4(1 or 2 nm)–Ta2O5 (5 nm), and Al–p-Si–SiO2(3.6 nm)–Ta2O5(5 nm) layer structures are characterized in buffer solution with different pH values by means of capacitance–voltage and constant capacitance method. The SiO2 and Si3N4 gate insulators are deposited by rapid thermal oxidation and rapid thermal nitridation, respectively, whereas the Ta2O5 film is prepared by atomic layer deposition. All EISCAP systems have a clear pH response, favoring the stacked gate insulators SiO2–Ta2O5 when considering the overall sensor characteristics, while the Si3N4(1 nm)–Ta2O5 stack delivers the largest accumulation capacitance (due to the lower equivalent oxide thickness) and a higher steepness in the slope of the capacitance–voltage curve among the studied stacked gate insulator systems.
KW  - atomic layer deposition
KW  - capacitive field-effect sensors
KW  - pH sensors
KW  - ultrathin gate insulators
Y1  - 2022
U6  - http://dx.doi.org/10.1002/pssa.202100660
SN  - 1862-6319
VL  - 219
IS  - 8
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Katz, Evgeny
A1  - Schöning, Michael Josef
T1  - Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips
JF  - Electroanalysis
N2  - The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.
Y1  - 2017
U6  - http://dx.doi.org/10.1002/elan.201700208
SN  - 1521-4109
VL  - 29
IS  - 8
SP  - 1840
EP  - 1849
PB  - Wiley
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Molinnus, Denise
A1  - Sorich, Maren
A1  - Bartz, Alexander
A1  - Siegert, Petra
A1  - Willenberg, Holger S.
A1  - Lisdat, Fred
A1  - Poghossian, Arshak
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate
JF  - Sensors and Actuators B: Chemical
N2  - An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer’s solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.snb.2016.06.064
SN  - 0925-4005
VL  - 237
SP  - 190
EP  - 195
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Moseley, Fiona
A1  - Halamek, Jan
A1  - Kramer, Friederike
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Katz, Evgeny
T1  - An enzyme-based reversible CNOT logic gate realized in a flow system
JF  - Analyst
N2  - An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.
Y1  - 2014
U6  - http://dx.doi.org/10.1039/C4AN00133H
SN  - 1364-5528 (E-Journal) ; 0003-2654 (Print)
VL  - 139
IS  - 8
SP  - 1839
EP  - 1842
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Mourzina, Y.
A1  - Mai, T.
A1  - Poghossian, Arshak
A1  - Ermolenko, Y.
A1  - Yoshinobu, T.
A1  - Vlasov, Y.
A1  - Iwasaki, H.
A1  - Schöning, Michael Josef
T1  - K+-selective field-effect sensors as transducers for bioelectronic applications
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SN  - 0013-4686
SP  - 3333
EP  - 3339
ER  - 
TY  - JOUR
A1  - Näther, Niko
A1  - Auger, V.
A1  - Poghossian, Arshak
A1  - Koudelka-Hep, M.
A1  - Schöning, Michael Josef
T1  - A miniaturized flow-through cell in SU-8 technique for EIS sensors
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 994
EP  - 995
ER  - 
TY  - CHAP
A1  - Näther, Niko
A1  - Poghossian, Arshak
A1  - Platen, J.
A1  - Yoshinobu, T.
A1  - Koudelka-Hep, M.
A1  - Schöning, Michael Josef
T1  - Multi-parameter sensing of both physical and (bio-)chemical quantities using the same transducer principle
T2  - Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...
Y1  - 2006
SP  - 172
EP  - 181
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Näther, Niko
A1  - Rolka, David
A1  - Poghossian, Arshak
A1  - Koudelka-Hep, M.
A1  - Schöning, Michael Josef
T1  - Two microcell flow-injection analysis (FIA) platforms for capacitive silicon-based field-effect sensors
JF  - Electrochimica Acta. 51 (2005), H. 5
Y1  - 2005
SN  - 0013-4686
U6  - http://dx.doi.org/10.1016/j.electacta.2005.04.066
SP  - 924
EP  - 929
ER  - 
TY  - JOUR
A1  - Pita, Marcos
A1  - Krämer, Melina
A1  - Zouh, Jian
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Fernandez, Victor M.
A1  - Katz, Evgeny
T1  - Optoelectronic Properties of Nanostructured Ensembles Controlled by Biomolecular Logic Systems
JF  - ACS Nano. 10 (2008), H. 2
Y1  - 2008
SN  - 1936-086X
SP  - 2160
EP  - 2166
ER  - 
TY  - CHAP
A1  - Platen, J.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Präparation von selbstjustierenden Nanostrukturen mittels Schichtausdehnungstechnik
T2  - Sensoren und Mess-Systeme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau
Y1  - 2006
SN  - 3-8007-2939-3
SP  - 277
EP  - 280
PB  - VDE Verl.
CY  - Berlin
ER  - 
TY  - CHAP
A1  - Platen, Johannes
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Microstructured Nanostructures – nanostructuring by means of conventional photolithography and layer-expansion technique
N2  - A new and simple method for nanostructuring using conventional photolithography and layer expansion or pattern-size reduction technique is presented, which can further be applied for the fabrication of different nanostructures and nano-devices. The method is based on the conversion of a photolithographically patterned metal layer to a metal-oxide mask with improved pattern-size resolution using thermal oxidation. With this technique, the pattern size can be scaled down to several nanometer dimensions. The proposed method is experimentally demonstrated by preparing nanostructures with different configurations and layouts, like circles, rectangles, trapezoids, “fluidic-channel”-, “cantilever”- and meander-type structures.
KW  - Biosensor
KW  - Nanostructuring
KW  - layer expansion
KW  - pattern-size reduction
KW  - self-aligned patterning
Y1  - 2006
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1477
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Amberger, F.
A1  - Mayer, D.
A1  - Han, Y.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Field-effect sensors with charged macromolecules: Characterisation by capacitance–voltage, constant-capacitance, impedance spectroscopy and atomic-force microscopy methods
JF  - Biosensors and Bioelectronics. 22 (2007), H. 9-10
Y1  - 2007
SN  - 0956-5663
N1  - Selected Papers from the Ninth World Congress On Biosensors. Toronto, Canada 10 - 12 May 2006, Alice X. J . Tang
SP  - 2100
EP  - 2107
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Nanocrystalline diamond-based field-effect (bio-)chemical sensor
JF  - 8. Dresdner Sensor-Symposium : Sensoren für Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme für die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung für die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)
Y1  - 2007
SN  - 978-3-940046-45-1
N1  - Dresdner Sensor-Symposium <8, 2007, Dresden> ; Dresdner Beiträge zur Sensorik ; 29
SP  - 191
EP  - 194
PB  - TUDpress, Verl. der Wissenschaften
CY  - Dresden
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Christiaens, P.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors
JF  - Journal of Contemporary Physics. 43 (2008), H. 2
Y1  - 2008
SN  - 1934-9378
N1  - Armenian Academy of Sciences
SP  - 77
EP  - 81
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Razavi, A.
A1  - Bäcker, Matthias
A1  - Bijnens, N.
A1  - Williams, O. A.
A1  - Haenen, K.
A1  - Moritz, W.
A1  - Wagner, P.
A1  - Schöning, Michael Josef
T1  - Nanocrystalline-diamond thin films with high pH and penicillin sensitivity prepared on a capacitive Si–SiO2 structure
JF  - Electrochimica Acta. 54 (2009), H. 25
Y1  - 2009
SN  - 0013-4686
SP  - 5981
EP  - 5985
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Sakkari, M.
A1  - Kassab, T.
A1  - Han, Y.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Field-effect sensors for monitoring the layer-by-layer adsorption of charged macromolecules
JF  - Sensors and Actuators B: Chemical. 118 (2006), H. 1-2
Y1  - 2006
SN  - 0925-4005
N1  - Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers
SP  - 163
EP  - 170
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
T1  - Capacitance–voltage and impedance characteristics of field-effect EIS sensors functionalised with polyelectrolyte multilayers
JF  - IRBM. 29 (2008), H. 2-3
Y1  - 2008
SN  - 1959-0318
SP  - 149
EP  - 154
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Baade, A.
A1  - Emons, H.
A1  - Schöning, Michael Josef
T1  - Application of ISFET for pH measurements in rain droplets
JF  - Sensors and Actuators B. 76 (2001), H. 1-3
Y1  - 2001
SN  - 0925-4005
SP  - 634
EP  - 638
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, L.
A1  - Schultze, J. W.
A1  - Lüth, H.
A1  - Schöning, Michael Josef
T1  - „High order“ hybrid sensor module based on an identical transducer principle
JF  - Chemical and biological sensors and analytical methods : proceedings of the international symposium / Sensor, Physical Electrochemistry, and Organic and Biological Electrochemistry Divisions. Ed.: M. Butler
Y1  - 2001
SN  - 1-56677-351-2
N1  - International Symposium: Chemical and Biological Sensors and Analytical Methods ; (2 : 2001.)
SP  - 143
EP  - 152
PB  - Electrochemical Society
CY  - Pennington, NJ
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, L.
A1  - Schöning, Michael Josef
T1  - Chemical sensor as a physical sensor: ISFET-based flowvelocity, flow-direction and diffusion-coefficient sensor
JF  - Book of abstracts / ed. by J. Saneistr.
Y1  - 2002
SN  - 80-01-02576-4
N1  - Eurosensors ; (16, 2002, Praha)
SP  - 649
EP  - 652
PB  - Czech Technical University, Faculty of Electrical Engineering, Department of Measurement
CY  - Prague
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, Lars
A1  - Lüth, Hans
A1  - Schöning, Michael Josef
T1  - Novel concepts for flow-rate and flow-direction determination by means of pH-sensitive ISFETs
JF  - Proceedings of SPIE. 4560 (2001)
Y1  - 2001
SP  - 19
EP  - 27
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Berndsen, Lars
A1  - Schöning, Michael Josef
T1  - Chemical sensor as physical sensor: ISFET-based flowvelocity, flow-direction and diffusion-coefficient sensor
JF  - Sensors and Actuators B. 95 (2003), H. 1-3
Y1  - 2003
SN  - 0925-4005
SP  - 384
EP  - 390
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Bronder, Thomas
A1  - Scheja, S.
A1  - Wu, Chunsheng
A1  - Metzger-Boddien, C.
A1  - Keusgen, M.
A1  - Schöning, Michael Josef
T1  - Label-free Electrostatic Detection of DNA Amplification by PCR Using Capacitive Field-effect Devices
T2  - Procedia Engineering
N2  - A capacitive field-effect EIS (electrolyte-insulator-semiconductor) sensor modified with a positively charged weak polyelectrolyte of poly(allylamine hydrochloride) (PAH)/single-stranded probe DNA (ssDNA) bilayer has been used for a label-free electrostatic detection of pathogen-specific DNA amplification via polymerase chain reaction (PCR). The sensor is able to distinguish between positive and negative PCR solutions, to detect the existence of target DNA amplicons in PCR samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.proeng.2016.11.512
SN  - 1877-7058
N1  - Proceedings of the 30th anniversary Eurosensors Conference – Eurosensors 2016, 4-7. Sepember 2016, Budapest, Hungary
VL  - Vol. 168
SP  - 514
EP  - 517
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Bronder, Thomas
A1  - Wu, Chunsheng
A1  - Schöning, Michael Josef
T1  - Label-free sensing of biomolecules by their intrinsic molecular charge using field-effect devices
T2  - Semiconductor Micro- and Nanoelectonics : Proceedings of the tenth international conference, Yerevan, Armenia, September 11-13
Y1  - 2015
SN  - 978-5-8084-1991-9
SP  - 61
EP  - 63
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Bäcker, Matthias
A1  - Mayer, Dirk
A1  - Schöning, Michael Josef
T1  - Gating capacitive field-effect sensors by the charge of nanoparticle/molecule hybrids
JF  - Nanoscale
Y1  - 2015
U6  - http://dx.doi.org/10.1039/C4NR05987E
SN  - 2040-3372 (E-Journal); 2040-3364 (Print)
SP  - 1023
EP  - 1031
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Cherstvy, A.
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Possibilities and limitations of label-free detection of DNA hybridization with field-effect-based devices
JF  - Sensors and Actuators B. 111-112 (2005)
Y1  - 2005
SN  - 0925-4005
N1  - Eurosensors XVIII 2004 — The 18th European Conference on Solid-State Transducers
SP  - 470
EP  - 480
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Cherstvy, A.
A1  - Schöning, Michael Josef
T1  - Possibilities and limitations of label-free detection of DNA hybridization with field-effect based devices
JF  - Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale].
Y1  - 2004
SN  - 88-7621-282-5
N1  - Eurosensors ; (18, 2004, Roma)
SP  - 173
EP  - 176
CY  - Roma
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Geissler, Hanno
A1  - Schöning, Michael Josef
T1  - Rapid methods and sensors for milk quality monitoring and spoilage detection
JF  - Biosensors and Bioelectronics
Y1  - 2019
U6  - http://dx.doi.org/10.1016/j.bios.2019.04.040
SN  - 0956-5663
VL  - 140
IS  - Article 111272
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Abouzar, Maryam H.
A1  - Schöning, Michael Josef
T1  - Label-free detection of charged macromolecules by using a field-effect-based sensor platform: Experiments and possible mechanisms of signal generation
JF  - Applied Physics A: Materials Science & Processing. 87 (2007), H. 3
Y1  - 2007
SN  - 0947-8396
N1  - Special Issue “From Surface Science to Nanoscale Devices”
SP  - 517
EP  - 524
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Field-effect devices for detecting cellular signals
JF  - Seminars in Cell & Developmental Biology. 20 (2009), H. 1
Y1  - 2009
SN  - 1096-3634
SP  - 41
EP  - 48
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Platen, J.
A1  - Schöning, Michael Josef
T1  - Field-effect sensors with charged macromolecules – from micro towards nano aspects
T2  - Biochemical Sensing Utilisation of Micro-and                       Nanotechnologies, Warschau, Nov. 2005 : Lecture Notes of the                       ICB Seminar / ed.: M. Mascini, W. Torbicz
Y1  - 2006
SP  - 74
EP  - 81
PB  - Polish Academy Sciences Press
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Ingebrandt, S.
A1  - Yeung, C.-K.
A1  - Offenhäusser, A.
A1  - Schöning, Michael Josef
T1  - Microsensors based on ion-sensitive field-effect transistors for biomedical applications
JF  - Biomedizinische Technik. 49 (2004), H. 2
Y1  - 2004
SN  - 0932-4666
SP  - 1036
EP  - 1037
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Jablonski, Melanie
A1  - Koch, Claudia
A1  - Bronder, Thomas
A1  - Rolka, David
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Field-effect biosensor using virus particles as scaffolds for enzyme immobilization
JF  - Biosensors and Bioelectronics
N2  - A field-effect biosensor employing tobacco mosaic virus (TMV) particles as scaffolds for enzyme immobilization is presented. Nanotubular TMV scaffolds allow a dense immobilization of precisely positioned enzymes with retained activity. To demonstrate feasibility of this new strategy, a penicillin sensor has been developed by coupling a penicillinase with virus particles as a model system. The developed field-effect penicillin biosensor consists of an Al-p-Si-SiO₂-Ta₂O₅-TMV structure and has been electrochemically characterized in buffer solutions containing different concentrations of penicillin G. In addition, the morphology of the biosensor surface with virus particles was characterized by scanning electron microscopy and atomic force microscopy methods. The sensors possessed a high penicillin sensitivity of ~ 92 mV/dec in a nearly-linear range from 0.1 mM to 10 mM, and a low detection limit of about 50 µM. The long-term stability of the penicillin biosensor was periodically tested over a time period of about one year without any significant loss of sensitivity. The biosensor has also been successfully applied for penicillin detection in bovine milk samples.
Y1  - 2018
U6  - http://dx.doi.org/10.1016/j.bios.2018.03.036
SN  - 0956-5663
VL  - 110
SP  - 168
EP  - 174
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Jablonski, Melanie
A1  - Molinnus, Denise
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers
JF  - Frontiers in Plant Science
N2  - Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases.
Y1  - 2020
U6  - http://dx.doi.org/10.3389/fpls.2020.598103
VL  - 11
IS  - Article 598103
SP  - 1
EP  - 14
PB  - Frontiers
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Karschuck, Tobias
A1  - Wagner, Patrick
A1  - Schöning, Michael Josef
T1  - Field-Effect Capacitors Decorated with Ligand-Stabilized Gold Nanoparticles: Modeling and Experiments
JF  - Biosensors
N2  - Nanoparticles are recognized as highly attractive tunable materials for designing field-effect biosensors with enhanced performance. In this work, we present a theoretical model for electrolyte-insulator-semiconductor capacitors (EISCAP) decorated with ligand-stabilized charged gold nanoparticles. The charged AuNPs are taken into account as additional, nanometer-sized local gates. The capacitance-voltage (C–V) curves and constant-capacitance (ConCap) signals of the AuNP-decorated EISCAPs have been simulated. The impact of the AuNP coverage on the shift of the C–V curves and the ConCap signals was also studied experimentally on Al–p-Si–SiO₂ EISCAPs decorated with positively charged aminooctanethiol-capped AuNPs. In addition, the surface of the EISCAPs, modified with AuNPs, was characterized by scanning electron microscopy for different immobilization times of the nanoparticles.
KW  - aminooctanethiol
KW  - nanoparticle coverage
KW  - capacitive model
KW  - gold nanoparticles
KW  - field-effect sensor
KW  - electrolyte-insulator-semiconductor capacitors
Y1  - 2022
U6  - http://dx.doi.org/10.3390/bios12050334
SN  - 2079-6374
N1  - This article belongs to the Special Issue "Biosensors in Nanotechnology"
VL  - 12
IS  - 5
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Katz, Evgeny
A1  - Schöning, Michael Josef
T1  - Enzyme logic AND-Reset and OR-Reset gates based on a field-effect electronic transducer modified with multi-enzyme membrane
JF  - Chemical Communications
N2  - Capacitive field-effect sensors modified with a multi-enzyme membrane have been applied for an electronic transduction of biochemical signals processed by enzyme-based AND-Reset and OR-Reset logic gates. The local pH change at the sensor surface induced by the enzymatic reaction was used for the activation of the Reset function for the first time.
Y1  - 2015
U6  - http://dx.doi.org/10.1039/C5CC01362C
VL  - 51
SP  - 6564
EP  - 6567
PB  - Royal Society of Chemistry (RSC)
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Lüth, H.
A1  - Schultze, J. W.
A1  - Schöning, Michael Josef
T1  - (Bio-)chemical and physical microsensor array using an identical transducer principle
JF  - Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz
Y1  - 2001
SN  - 0-08-044014-2
SP  - 243
EP  - 249
PB  - Elsevier [u.a.]
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Mai, D.-T.
A1  - Mourzina, Y.
A1  - Schöning, Michael Josef
T1  - Impedance effect of an ion-sensitive membrane: characterisation of an EMIS sensor by impedance spectroscopy, capacitance-voltage and constant-capacitance method
JF  - Sensors and Actuators B. 103 (2004), H. 1-2
Y1  - 2004
SN  - 0925-4005
SP  - 423
EP  - 428
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Malzahn, K.
A1  - Abouzar, Maryam H.
A1  - Mehndiratta, P.
A1  - Katz, E.
A1  - Schöning, Michael Josef
T1  - Integration of biomolecular logic gates with field-effect transducers
JF  - Electrochimica Acta. 56 (2011), H. 26
Y1  - 2011
SN  - 0013-4686
SP  - 9661
EP  - 9665
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Platen, J.
A1  - Schöning, Michael Josef
T1  - Towards self-aligned nanostructures by means of layerexpansion technique
JF  - Electrochimica Acta. 51 (2005), H. 5
Y1  - 2005
SN  - 0013-4686
SP  - 838
EP  - 843
ER  - 
TY  - JOUR
A1  - Poghossian, Arshak
A1  - Schultze, J. W.
A1  - Schöning, Michael Josef
T1  - Application of a (bio-)chemical sensor (ISFET) for the detection of physical parameters in liquids
JF  - Electrochimica Acta. 48 (2003), H. 20-22
Y1  - 2003
SP  - 3289
EP  - 3297
ER  -