TY - CHAP A1 - Molinnus, Denise A1 - Hardt, Gabriel A1 - Käver, Larissa A1 - Willenberg, Holger S. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology T2 - MDPI Proceedings Y1 - 2017 U6 - http://dx.doi.org/10.3390/proceedings1040506 ER - TY - JOUR A1 - Molinnus, Denise A1 - Hardt, G. A1 - Käver, L. A1 - Willenberg, H.S. A1 - Kröger, J.-C. A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling JF - Sensor and Actuators B: Chemical N2 - A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.snb.2018.05.136 SN - 0925-4005 VL - 272 SP - 21 EP - 27 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Molinnus, Denise A1 - Drinic, Aleksander A1 - Iken, Heiko A1 - Kröger, Nadja A1 - Zinser, Max A1 - Smeets, Ralf A1 - Köpf, Marius A1 - Kopp, Alexander A1 - Schöning, Michael Josef T1 - Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk JF - Biosensors and Bioelectronics Y1 - 2021 U6 - http://dx.doi.org/10.1016/j.bios.2021.113204 SN - 0956-5663 VL - 183 IS - Art. 113204 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Molinnus, Denise A1 - Bäcker, Matthias A1 - Siegert, Petra A1 - Willenberg, H. A1 - Poghossian, Arshak A1 - Keusgen, M. A1 - Schöning, Michael Josef T1 - Detection of Adrenaline Based on Substrate Recycling Amplification JF - Procedia Engineering N2 - An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.708 SN - 1877-7058 N1 - Eurosensors 2015 VL - 120 SP - 540 EP - 543 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Molinnus, Denise A1 - Bäcker, Matthias A1 - Iken, Heiko A1 - Poghossian, Arshak A1 - Keusgen, Michael A1 - Schöning, Michael Josef T1 - Concept for a biomolecular logic chip with an integrated sensor and actuator function JF - Physica status solidi (a) N2 - A concept for a new generation of an integrated multi-functional biosensor/actuator system is developed, which is based on biomolecular logic principles. Such a system is expected to be able to detect multiple biochemical input signals simultaneously and in real-time and convert them into electrical output signals with logical operations such as OR, AND, etc. The system can be designed as a closed-loop drug release device triggered by an enzyme logic gate, while the release of the drug induced by the actuator at the required dosage and timing will be controlled by an additional drug sensor. Thus, the system could help to make an accurate and specific diagnosis. The presented concept is exemplarily demonstrated by using an enzyme logic gate based on a glucose/glucose oxidase system, a temperature-responsive hydrogel mimicking the actuator function and an insulin (drug) sensor. In this work, the results of functional testing of individual amperometric glucose and insulin sensors as well as an impedimetric sensor for the detection of the hydrogel swelling/shrinking are presented. Y1 - 2015 U6 - http://dx.doi.org/10.1002/pssa.201431913 SN - 1862-6319 VL - 212 IS - 6 SP - 1382 EP - 1388 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Miyamoto, Koichiro A1 - Seki, Kosuke A1 - Suto, Takeyuki A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers JF - Sensor and Actuators B: Chemical N2 - The chemical imaging sensor is a semiconductor-based chemical sensor capable of visualizing pH and ion distributions. The spatial resolution depends on the lateral diffusion of photocarriers generated by illumination of the semiconductor substrate. In this study, two types of optical setups, one based on a bundle of optical fibers and the other based on a binocular tube head, were developed to project a hybrid illumination of a modulated light beam and a ring-shaped constant illumination onto the sensor plate. An improved spatial resolution was realized by the ring-shaped constant illumination, which suppressed lateral diffusion of photocarriers by enhanced recombination due to the increased carrier concentration. Y1 - 2018 U6 - http://dx.doi.org/10.1016/j.snb.2018.07.016 SN - 0925-4005 VL - 273 SP - 1328 EP - 1333 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Yoshida, Midori A1 - Sakai, Taito A1 - Matsuzaka, Atsushi A1 - Wagner, Torsten A1 - Kanoh, Sanoh A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Differential setup of light-addressable potentiometric sensor with an enzyme reactor in a flow channel JF - Japanese Journal of Applied Physics. 50 (2011) Y1 - 2011 SN - 0021-4922 SP - 04DL08-1 EP - 04DL08-5 PB - Japan Society of Applied Physics CY - Bristol ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef T1 - Phase-mode LAPS and its application to chemical imaging JF - Sensors and Actuators B: Chemical. 154 (2011), H. 1 Y1 - 2011 SN - 1873-3077 SP - 28 EP - 32 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef T1 - Phase-mode operation of FDM-LAPS JF - Sensor letters Y1 - 2011 SN - 1546-1971 VL - 9 IS - 2 SP - 691 EP - 694 PB - American Scientific Publishers CY - Stevenson Ranch, Calif. ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Mimura, Shuhei A1 - Kanoh, Shiníchiro A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Constant-phase-mode operation of the light-addressable potentiometric sensor JF - Sensors and Actuators B: Chemical. 154 (2011), H. 2 Y1 - 2011 SN - 1873-3077 N1 - EUROSENSORS XXIII SP - 119 EP - 123 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Wagner, Torsten A1 - Mimura, Shuhei A1 - Kanoh, Shin`ichiro A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Constant-phase-mode operation of the light-addressable potentiometric sensor JF - Procedia Chemistry. 1 (2009), H. 1 Y1 - 2009 SN - 1876-6196 N1 - Proceedings of the Eurosensors XXIII conference ; Eurosensors 23 SP - 1487 EP - 1490 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Miyamoto, Ko-ichiro A1 - Suto, Takeyuki A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor T2 - MDPI Proceedings Y1 - 2017 U6 - http://dx.doi.org/10.3390/proceedings1040477 N1 - Eurosensors 2017 Conference, Paris, France, 3–6 September 2017 VL - 1 IS - 4 ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Sugawara, Yuri A1 - Kanoh, Shin´ichiro A1 - Yoshinobu, Tatsuo A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Image correction method for the chemical imaging sensor JF - Sensors and Actuators B: Chemical. 144 (2010), H. 2 Y1 - 2010 N1 - 22nd International Conference on Eurosensors - Dresden, Germany, 7-10 September 2008 ; Eurosensors ; (22, 2008, Dresden) SP - 344 EP - 348 ER - TY - JOUR A1 - Miyamoto, Ko-Ichiro A1 - Sato, Takuya A1 - Abe, Minami A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Light-addressable potentiometric sensor as a sensing element in plug-based microfluidic devices JF - Micromachines N2 - A plug-based microfluidic system based on the principle of the light-addressable potentiometric sensor (LAPS) is proposed. The LAPS is a semiconductor-based chemical sensor, which has a free addressability of the measurement point on the sensing surface. By combining a microfluidic device and LAPS, ion sensing can be performed anywhere inside the microfluidic channel. In this study, the sample solution to be measured was introduced into the channel in a form of a plug with a volume in the range of microliters. Taking advantage of the light-addressability, the position of the plug could be monitored and pneumatically controlled. With the developed system, the pH value of a plug with a volume down to 400 nL could be measured. As an example of plug-based operation, two plugs were merged in the channel, and the pH change was detected by differential measurement. KW - light-addressable potentiometric sensor KW - plug-based microfluidic device KW - chemical sensor Y1 - 2016 U6 - http://dx.doi.org/10.3390/mi7070111 SN - 2072-666X N1 - This article belongs to the Special Issue "Micro/Nano Devices for Chemical Analysis" VL - 7 IS - 7 SP - 111 PB - MDPI CY - Basel ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Kaneko, Kazumi A1 - Matsuo, Akira A1 - Wagner, Torsten A1 - Kanoh, Shiníchiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Miniaturized chemical imaging sensor system using an OLED display panel JF - Sensors and Actuators B: Chemical N2 - The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the two-dimensional distribution of specific ions or molecules in the solution. In this study, we developed a miniaturized chemical imaging sensor system with an OLED display panel as a light source that scans the sensor plate. In the proposed configuration, the display panel is placed directly below the sensor plate and illuminates the back surface. The measured area defined by illumination can be arbitrarily customized to fit the size and the shape of the sample to be measured. The waveform of the generated photocurrent, the current–voltage characteristics and the pH sensitivity were investigated and pH imaging with this miniaturized system was demonstrated. KW - LAPS KW - Light-addressable potentiometric sensor KW - Chemical imaging sensor KW - Organic light-emitting diode display Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.snb.2011.02.029 SN - 0925-4005 N1 - Part of special issue "Eurosensors XXIV, 2010" VL - 170 SP - 82 EP - 87 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Kaneko, Kazumi A1 - Matsuo, Akira A1 - Wagner, Torsten A1 - Kanoh, Shin`ichiro A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Miniaturized chemical imaging sensor system using an OLED display panel JF - Procedia Engineering. 5 (2010) Y1 - 2010 SN - 1877-7058 N1 - Eurosensor XXIV Conference SP - 516 EP - 519 ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Itabashi, Akinori A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - High-speed chemical imaging inside a microfluidic channel JF - Sensors and actuators. B: Chemical N2 - In this study, a high-speed chemical imaging system was developed for visualization of the interior of a microfluidic channel. A microfluidic channel was constructed on the sensor surface of the light-addressable potentiometric sensor (LAPS), on which the ion concentrations could be measured in parallel at up to 64 points illuminated by optical fibers. The temporal change of pH distribution inside the microfluidic channel was recorded at a maximum rate of 100 frames per second (fps). The high frame rate allowed visualization of moving interfaces and plugs in the channel even at a flow velocity of 111 mm/s, which suggests the feasibility of plug-based microfluidic devices for flow-injection analysis (FIA). Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.snb.2013.12.090 SN - 1873-3077 (E-Journal); 0925-4005 (Print) VL - 194 SP - 521 EP - 527 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Ichimura, Hiroki A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Chemical imaging of the concentration profile of ion diffusion in a microfluidic channel JF - Sensors and actuators. B: Chemical N2 - The chemical imaging sensor is a device to visualize the spatial distribution of chemical species based on the principle of LAPS (light-addressable potentiometric sensor), which is a field-effect chemical sensor based on semiconductor. In this study, the chemical imaging sensor has been applied to investigate the ion profile of laminar flows in a microfluidic channel. The chemical images (pH maps) were collected in a Y-shaped microfluidic channel while injecting HCl and NaCl solutions into two branches. From the chemical images, it was clearly observed that the injected solutions formed laminar flows in the channel. In addition, ion diffusion across the laminar flows was observed, and the diffusion coefficient could be derived by fitting the pH profiles to the Fick's equation. Y1 - 2013 U6 - http://dx.doi.org/10.1016/j.snb.2013.04.057 SN - 1873-3077 (E-Journal); 0925-4005 (Print) N1 - Part of special issue "Selected Papers from the 26th European Conference on Solid-State Transducers" VL - 189 SP - 240 EP - 245 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Hirayama, Yuji A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Visualization of enzymatic reaction in a microfluidic channel using chemical imaging sensor JF - Electrochimica acta Y1 - 2013 SN - 1873-3859 (E-Journal); 0013-4686 (Print) SP - Publ. online PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Hayashi, Kosuke A1 - Sakamoto, Azuma A1 - Werner, Frederik A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - A high-Q resonance-mode measurement of EIS capacitive sensor by elimination of series resistance JF - Sensor and Actuators B: Chemical N2 - An EIS capacitive sensor is a semiconductor-based potentiometric sensor, which is sensitive to the ion concentration or pH value of the solution in contact with the sensing surface. To detect a small change in the ion concentration or pH, a small capacitance change must be detected. Recently, a resonance-mode measurement was proposed, in which an inductor was connected to the EIS capacitive sensor and the resonant frequency was correlated with the pH value. In this study, the Q factor of the resonant circuit was enhanced by canceling the internal resistance of the reference electrode and the internal resistance of the inductor coil with the help of a bypass capacitor and a negative impedance converter, respectively. 1% variation of the signal in the developed system corresponded to a pH change of 3.93 mpH, which was about 1/12 of the conventional method, suggesting a better performance in detection of a small pH change. KW - Negative impedance convertor KW - Resonance-mode measurement KW - Chemical sensor KW - EIS capacitive sensor Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.snb.2017.03.002 SN - 0925-4005 VL - 248 SP - 1006 EP - 1010 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, Ko-ichiro A1 - Bing, Yu A1 - Wagner, Torsten A1 - Yoshinobu, Tatsuo A1 - Schöning, Michael Josef T1 - Visualization of Defects on a Cultured Cell Layer by Utilizing Chemical Imaging Sensor JF - Procedia Engineering N2 - The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) inthe sample. In this study, a novel wound-healing assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the defect of a cell layer brought into proximity of the sensing surface.A reduced impedance inside the defect, which was artificially formed ina cell layer, was successfully visualized in a photocurrent image. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.proeng.2015.08.806 SN - 1877-7058 N1 - Part of special issue "Eurosensors 2015" VL - 120 SP - 936 EP - 939 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, K. A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Multi-well structure for cell culture on the chemical imaging sensor Y1 - 2011 N1 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011 SP - 2130 EP - 2132 PB - IEEE CY - New York ER - TY - JOUR A1 - Miyamoto, K. A1 - Seki, K. A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, T. T1 - Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination JF - Procedia Engineering N2 - The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm. Y1 - 2014 U6 - http://dx.doi.org/10.1016/j.proeng.2014.11.563 SN - 1877-7058 N1 - EUROSENSORS 2014 ; European Conference on Solid-State Transducers <28, 2014> VL - 87 SP - 612 EP - 615 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, K. A1 - Kuwabara, Yohei A1 - Kanoh, Shin'ichiro A1 - Yoshinobu, Tatsuo A1 - Wagner, Torsten A1 - Schöning, Michael Josef T1 - Chemical image scanner based on FDM-LAPS JF - Sensors and Actuators B: Chemical. 137 (2009), H. 2 Y1 - 2009 SN - 0925-4005 SP - 533 EP - 538 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamoto, K. A1 - Ichimura, H. A1 - Wagner, Torsten A1 - Yoshinobu, T. A1 - Schöning, Michael Josef T1 - Chemical Imaging of ion Diffusion in a Microfluidic Channel JF - Procedia Engineering N2 - The chemical imaging sensor is a chemical sensor which is capable of visualizing the spatial distribution of chemical species in sample solution. In this study, a novel measurement system based on the chemical imaging sensor was developed to observe the inside of a Y-shaped microfluidic channel while injecting two sample solutions from two branches. From the collected chemical images, it was clearly observed that the injected solutions formed laminar flows in the microfluidic channel. In addition, ion diffusion across the laminar flows was observed. This label-free method can acquire quantitative data of ion distribution and diffusion in microfluidic devices, which can be used to determine the diffusion coefficients, and therefore, the molecular weights of chemical species in the sample solution. Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.proeng.2012.09.289 SN - 1877-7058 N1 - Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" IS - 47 SP - 886 EP - 889 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Miyamato, Ko-ichiro A1 - Sakakita, Sakura A1 - Wagner, Torsten A1 - Schöning, Michael Josef A1 - Yoshinobu, Tatsuo T1 - Application of chemical imaging sensor to in-situ pH imaging in the vicinity of a corroding metal surface JF - Electrochimica Acta N2 - The chemical imaging sensor was applied to in-situ pH imaging of the solution in the vicinity of a corroding surface of stainless steel under potentiostatic polarization. A test piece of polished stainless steel was placed on the sensing surface leaving a narrow gap filled with artificial seawater and the stainless steel was corroded under polarization. The pH images obtained during polarization showed correspondence between the region of lower pH and the site of corrosion. It was also found that the pH value in the gap became as low as 2 by polarization, which triggered corrosion. Y1 - 2015 U6 - http://dx.doi.org/10.1016/j.electacta.2015.07.184 SN - 0013-4686 VL - 183 SP - 137 EP - 142 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Mirmohseni, Abdolreza A1 - Rostamizadeh, Kobra T1 - Quartz crystal nanobalance in conjunction with principal component analysis for identification of volatile organic compounds N2 - Quartz crystal nanobalance (QCN) sensors are considered as powerful masssensitive sensors to determine materials in the sub-nanogram level. In this study, a single piezoelectric quartz crystal nanobalance modified with polystyrene was employed to detect benzene, toluene, ethylbenzene and xylene (BTEX compounds). The frequency shift of the QCN sensor was found to be linear against the BTEX compound concentrations in the range about 1-45 mg l-1. The correlation coefficients for benzene, toluene, ethylbenzene, and xylene were 0.991, 0.9977, 0.9946 and 0.9971, respectively. The principal component analysis was also utilized to process the frequency response data of the single piezoelectric crystal at different times, considering to the different adsorption-desorption dynamics of BTEX compounds. Using principal component analysis, it was found that over 90% of the data variance could still be explained by use of two principal components (PC1 and PC2). Subsequently, the successful identification of benzene and toluene was possible through the principal component analysis of the transient responses of the polystyrene modified QCN sensor. The results showed that the polystyrene-modified QCN had favorable identification and quantification performances for the BTEX compounds. KW - Biosensor KW - Quartz crystal nanobalance (QCN) KW - BTEX compounds KW - principal component Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1434 ER - TY - JOUR A1 - Mikielewicz, Marek A1 - Kotliar, Konstantin A1 - Barraquer, Rafael I. A1 - Michael, Ralph T1 - Air-pulse corneal applanation signal curve parameters for the characterisation of keratoconus JF - British Journal of Ophthalmology (eBJO) Y1 - 2011 SN - 1468-2079 VL - 95 IS - 6 SP - 793 EP - 798 PB - BMJ Publ. Group CY - London ER - TY - JOUR A1 - Micili, Serap C. A1 - Valter, Markus A1 - Oflaz, Hakan A1 - Ozogul, Candan A1 - Linder, Peter A1 - Föckler, Nicole A1 - Artmann, Gerhard A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül T1 - Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes JF - Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine Y1 - 2013 SN - 0046-2039 (Print) ; 2041-3033 (E-Journal) VL - Vol. 227 IS - No. 4 SP - 393 EP - 401 PB - Sage CY - London ER - TY - JOUR A1 - Michael, Hackl A1 - Mayer, Katharina A1 - Weber, Mareike A1 - Staat, Manfred A1 - van Riet, Roger A1 - Burkhart, Klau Josef A1 - Müller, Lars Peter A1 - Wegmann, Kilian T1 - Plate osteosynthesis of proximal ulna fractures : a biomechanical micromotion analysis JF - The journal of hand surgery Y1 - 2017 U6 - http://dx.doi.org/10.1016/j.jhsa.2017.05.014 SN - 0363-5023 VL - 42 IS - 10 SP - 834.e1 EP - 834.e7 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Meyer, Carolin A1 - Gaalen, Kerstin van A1 - Leschinger, Tim A1 - Scheyerer, Max J. A1 - Neiss, Wolfram F. A1 - Staat, Manfred A1 - Müller, Lars P. A1 - Wegmann, Kilian T1 - Kyphoplasty of Osteoporotic Fractured Vertebrae: A Finite Element Analysis about Two Types of Cement JF - BioMed Research International Y1 - 2019 U6 - http://dx.doi.org/10.1155/2019/9232813 SP - Article ID 9232813 ER - TY - JOUR A1 - Mennicken, Max A1 - Peter, Sophia Katharina A1 - Kaulen, Corinna A1 - Simon, Ulrich A1 - Karthäuser, Silvia T1 - Controlling the Electronic Contact at the Terpyridine/Metal Interface JF - The Journal of Physical Chemistry C Y1 - 2019 U6 - http://dx.doi.org/10.1021/acs.jpcc.9b05865 SN - 1932-7455 VL - 123 IS - 35 SP - 21367 EP - 21375 ER - TY - JOUR A1 - Mennicken, Max A1 - Peter, Sophia K. A1 - Kaulen, Corinna A1 - Simon, Ulrich A1 - Karthäuser, Silvia T1 - Transport through Redox-Active Ru-Terpyridine Complexes Integrated in Single Nanoparticle Devices JF - The Journal of Physical Chemistry C N2 - Transition metal complexes are electrofunctional molecules due to their high conductivity and their intrinsic switching ability involving a metal-to-ligand charge transfer. Here, a method is presented to contact reliably a few to single redox-active Ru-terpyridine complexes in a CMOS compatible nanodevice and preserve their electrical functionality. Using hybrid materials from 14 nm gold nanoparticles (AuNP) and bis-{4′-[4-(mercaptophenyl)-2,2′:6′,2″-terpyridine]}-ruthenium(II) complexes a device size of 30² nm² inclusive nanoelectrodes is achieved. Moreover, this method bears the opportunity for further downscaling. The Ru-complex AuNP devices show symmetric and asymmetric current versus voltage curves with a hysteretic characteristic in two well separated conductance ranges. By theoretical approximations based on the single-channel Landauer model, the charge transport through the formed double-barrier tunnel junction is thoroughly analyzed and its sensibility to the molecule/metal contact is revealed. It can be verified that tunneling transport through the HOMO is the main transport mechanism while decoherent hopping transport is present to a minor extent. Y1 - 2020 U6 - http://dx.doi.org/10.1021/acs.jpcc.9b11716 SN - 1932-7455 VL - 124 IS - 8 SP - 4881 EP - 4889 PB - ACS Publications CY - Washington, DC ER - TY - CHAP A1 - Maurer, Florian A1 - Miskiw, Kim K. A1 - Acosta, Rebeca Ramirez A1 - Harder, Nick A1 - Sander, Volker A1 - Lehnhoff, Sebastian ED - Jorgensen, Bo Norregaard ED - Pereira da Silva, Luiz Carlos ED - Ma, Zheng T1 - Market abstraction of energy markets and policies - application in an agent-based modeling toolbox T2 - EI.A 2023: Energy Informatics N2 - In light of emerging challenges in energy systems, markets are prone to changing dynamics and market design. Simulation models are commonly used to understand the changing dynamics of future electricity markets. However, existing market models were often created with specific use cases in mind, which limits their flexibility and usability. This can impose challenges for using a single model to compare different market designs. This paper introduces a new method of defining market designs for energy market simulations. The proposed concept makes it easy to incorporate different market designs into electricity market models by using relevant parameters derived from analyzing existing simulation tools, morphological categorization and ontologies. These parameters are then used to derive a market abstraction and integrate it into an agent-based simulation framework, allowing for a unified analysis of diverse market designs. Furthermore, we showcase the usability of integrating new types of long-term contracts and over-the-counter trading. To validate this approach, two case studies are demonstrated: a pay-as-clear market and a pay-as-bid long-term market. These examples demonstrate the capabilities of the proposed framework. KW - Energy market design KW - Agent-based simulation KW - Market modeling Y1 - 2023 SN - 978-3-031-48651-7 (Print) SN - 978-3-031-48652-4 (eBook) U6 - http://dx.doi.org/10.1007/978-3-031-48652-4_10 N1 - Energy Informatics Academy Conference, 6-8 December 23, Campinas, Brazil. N1 - Part of the Lecture Notes in Computer Science book series (LNCS,volume 14468). SP - 139 EP - 157 PB - Springer CY - Cham ER - TY - CHAP A1 - Maurer, Florian T1 - Framework to provide a simulative comparison of different energy market designs T2 - Energy Informatics N2 - Useful market simulations are key to the evaluation of diferent market designs existing of multiple market mechanisms or rules. Yet a simulation framework which has a comparison of diferent market mechanisms in mind was not found. The need to create an objective view on different sets of market rules while investigating meaningful agent strategies concludes that such a simulation framework is needed to advance the research on this subject. An overview of diferent existing market simulation models is given which also shows the research gap and the missing capabilities of those systems. Finally, a methodology is outlined how a novel market simulation which can answer the research questions can be developed. Y1 - 2022 U6 - http://dx.doi.org/10.1186/s42162-022-00215-6 SN - 2520-8942 VL - 5 IS - 2 SP - 18 EP - 20 PB - Springer Nature ER - TY - JOUR A1 - Martin-Gonzalez, Anabel A1 - Kotliar, Konstantin A1 - Rios-Martinez, Jorge A1 - Lanzl, Ines A1 - Navab, Nassir T1 - Mediated-reality magnification for macular degeneration rehabilitation JF - Journal of Modern Optics Y1 - 2014 U6 - http://dx.doi.org/10.1080/09500340.2014.936110 SN - 1362-3044 VL - 61 IS - 17 SP - 1400 EP - 1408 PB - Taylor & Francis CY - London ER - TY - CHAP A1 - Mansurov, Zulkhair A1 - Zhubanova, Azhar A. A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül A1 - Savitskaja, Irina S. A1 - Kozhalakova, A. A. A1 - Kistaubaeva, Aida S. T1 - The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials N2 - Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it’s microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties – ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS. KW - Kohlenstofffaser KW - Lipopolysaccharide KW - nanostrukturierte carbonisierte Pflanzenteile KW - lipopolysaccharides KW - nanostructured carbonized plant parts Y1 - 2008 ER - TY - CHAP A1 - Mansurov, Zulkhair A. A1 - Jandosov, Jakpar A1 - Chenchik, D. A1 - Azat, Seitkhan A1 - Savitskaya, Irina S. A1 - Kistaubaeva, Aida A1 - Akimbekov, Nuraly A1 - Digel, Ilya A1 - Zhubanova, Azhar Achmet T1 - Biocomposite Materials Based on Carbonized Rice Husk in Biomedicine and Environmental Applications T2 - Carbon Nanomaterials in Biomedicine and the Environment N2 - This chapter describes the prospects for biomedical and environmental engineering applications of heterogeneous materials based on nanostructured carbonized rice husk. Efforts in engineering enzymology are focused on the following directions: development and optimization of immobilization methods leading to novel biotechnological and biomedical applications; construction of biocomposite materials based on individual enzymes, multi-enzyme complexes and whole cells, targeted on realization of specific industrial processes. Molecular biological and biochemical studies on cell adhesion focus predominantly on identification, isolation and structural analysis of attachment-responsible biological molecules and their genetic determinants. The chapter provides a short overview of applications of the biocomposite materials based of nanostructured carbonized adsorbents. It emphasizes that further studies and better understanding of the interactions between CNS and microbial cells are necessary. The future use of living cells as biocatalysts, especially in the environmental field, needs more systematic investigations of the microbial adsorption phenomenon. Y1 - 2020 SN - 978-981-4800-27-3 U6 - http://dx.doi.org/10.1201/9780429428647-2 SP - 3 EP - 32 PB - Jenny Stanford Publishing Pte. Ltd. CY - Singapore ER - TY - JOUR A1 - Mansurov, Z. A1 - Digel, Ilya A1 - Biisenbaev, M. A1 - Savistkaya, I. A1 - Kistaubaeva, A. A1 - Akimbekov, N. A1 - Zhubanova, A. T1 - Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications JF - Eurasian Chemico-Technological Journal Y1 - 2012 U6 - http://dx.doi.org/10.18321/ectj105 SN - 2522-4867 VL - 14 IS - 2 SP - 115 EP - 131 PB - Institute of Combustion Problems CY - Almaty ER - TY - JOUR A1 - Mansurov, Z. A. A1 - Jandosov, J. M. A1 - Kerimkulova, A. R. A1 - Azat, S. A1 - Zhubanova, A. A. A1 - Digel, Ilya A1 - Savistkaya, I. S. A1 - Akimbekov, N. S. A1 - Kistaubaeva, A. S. T1 - Nanostructured carbon materials for biomedical use JF - Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences N2 - One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials. Y1 - 2014 U6 - http://dx.doi.org/10.18321/ectj224 SN - 1562-3920 VL - 15 (2013) IS - 3 SP - 209 EP - 217 PB - Institute of Combustion Problems CY - Almaty ER - TY - CHAP A1 - Mandekar, Swati A1 - Jentsch, Lina A1 - Lutz, Kai A1 - Behbahani, Mehdi A1 - Melnykowycz, Mark T1 - Earable design analysis for sleep EEG measurements T2 - UbiComp '21 N2 - Conventional EEG devices cannot be used in everyday life and hence, past decade research has been focused on Ear-EEG for mobile, at-home monitoring for various applications ranging from emotion detection to sleep monitoring. As the area available for electrode contact in the ear is limited, the electrode size and location play a vital role for an Ear-EEG system. In this investigation, we present a quantitative study of ear-electrodes with two electrode sizes at different locations in a wet and dry configuration. Electrode impedance scales inversely with size and ranges from 450 kΩ to 1.29 MΩ for dry and from 22 kΩ to 42 kΩ for wet contact at 10 Hz. For any size, the location in the ear canal with the lowest impedance is ELE (Left Ear Superior), presumably due to increased contact pressure caused by the outer-ear anatomy. The results can be used to optimize signal pickup and SNR for specific applications. We demonstrate this by recording sleep spindles during sleep onset with high quality (5.27 μVrms). KW - EEG KW - sensors KW - Impedance Spectroscopy KW - Sleep EEG KW - biopotential electrodes Y1 - 2021 U6 - http://dx.doi.org/10.1145/3460418.3479328 N1 - UbiComp '21: Adjunct Proceedings of the 2021 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2021 ACM International Symposium on Wearable Computers, September 21–26, 2021, Virtual, USA SP - 171 EP - 175 ER - TY - JOUR A1 - Mandekar, Swati A1 - Holland, Abigail A1 - Thielen, Moritz A1 - Behbahani, Mehdi A1 - Melnykowycz, Mark T1 - Advancing towards Ubiquitous EEG, Correlation of In-Ear EEG with Forehead EEG JF - Sensors N2 - Wearable EEG has gained popularity in recent years driven by promising uses outside of clinics and research. The ubiquitous application of continuous EEG requires unobtrusive form-factors that are easily acceptable by the end-users. In this progression, wearable EEG systems have been moving from full scalp to forehead and recently to the ear. The aim of this study is to demonstrate that emerging ear-EEG provides similar impedance and signal properties as established forehead EEG. EEG data using eyes-open and closed alpha paradigm were acquired from ten healthy subjects using generic earpieces fitted with three custom-made electrodes and a forehead electrode (at Fpx) after impedance analysis. Inter-subject variability in in-ear electrode impedance ranged from 20 kΩ to 25 kΩ at 10 Hz. Signal quality was comparable with an SNR of 6 for in-ear and 8 for forehead electrodes. Alpha attenuation was significant during the eyes-open condition in all in-ear electrodes, and it followed the structure of power spectral density plots of forehead electrodes, with the Pearson correlation coefficient of 0.92 between in-ear locations ELE (Left Ear Superior) and ERE (Right Ear Superior) and forehead locations, Fp1 and Fp2, respectively. The results indicate that in-ear EEG is an unobtrusive alternative in terms of impedance, signal properties and information content to established forehead EEG. KW - in-ear EEG KW - correlation KW - forehead EEG KW - impedance spectroscopy KW - biopotential electrodes Y1 - 2022 U6 - http://dx.doi.org/10.3390/s22041568 SN - 1424-8220 VL - 22 IS - 4 SP - 1 EP - 19 PB - MDPI CY - Basel ER - TY - JOUR A1 - Malzahn, Kerstin A1 - Windmiller, Joshua Ray A1 - Valdés-Ramírez, Gabriela A1 - Wang, Joseph A1 - Schöning, Michael Josef T1 - Wearable electrochemical sensors for in situ analysis in marine environments JF - Analyst. 136 (2011), H. 14 Y1 - 2011 SN - 0003-2654 SP - 2912 EP - 2917 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Malinowski, Daniel A1 - Fournier, Yvan A1 - Horbach, Andreas A1 - Frick, Michael A1 - Magliani, Mirko A1 - Kalverkamp, Sebastian A1 - Hildinger, Martin A1 - Spillner, Jan A1 - Behbahani, Mehdi A1 - Hima, Flutura T1 - Computational fluid dynamics analysis of endoluminal aortic perfusion JF - Perfusion N2 - Introduction: In peripheral percutaneous (VA) extracorporeal membrane oxygenation (ECMO) procedures the femoral arteries perfusion route has inherent disadvantages regarding poor upper body perfusion due to watershed. With the advent of new long flexible cannulas an advancement of the tip up to the ascending aorta has become feasible. To investigate the impact of such long endoluminal cannulas on upper body perfusion, a Computational Fluid Dynamics (CFD) study was performed considering different support levels and three cannula positions. Methods: An idealized literature-based- and a real patient proximal aortic geometry including an endoluminal cannula were constructed. The blood flow was considered continuous. Oxygen saturation was set to 80% for the blood coming from the heart and to 100% for the blood leaving the cannula. 50% and 90% venoarterial support levels from the total blood flow rate of 6 l/min were investigated for three different positions of the cannula in the aortic arch. Results: For both geometries, the placement of the cannula in the ascending aorta led to a superior oxygenation of all aortic blood vessels except for the left coronary artery. Cannula placements at the aortic arch and descending aorta could support supra-aortic arteries, but not the coronary arteries. All positions were able to support all branches with saturated blood at 90% flow volume. Conclusions: In accordance with clinical observations CFD analysis reveals, that retrograde advancement of a long endoluminal cannula can considerably improve the oxygenation of the upper body and lead to oxygen saturation distributions similar to those of a central cannulation. KW - computational fluid dynamics analysis KW - simulation KW - endoluminal KW - aortic perfusion KW - extracorporeal membrane oxygenation Y1 - 2022 U6 - http://dx.doi.org/10.1177/02676591221099809 SN - 1477-111X VL - 0 IS - 0 SP - 1 EP - 8 PB - Sage CY - London ER - TY - JOUR A1 - Malan, Leone A1 - Hamer, Mark A1 - Känel, Roland von A1 - Kotliar, Konstantin A1 - Wyk, Roelof D. van A1 - Lambert, Gavin W. A1 - Vilser, Walthard A1 - Ziemssen, Tjalf A1 - Schlaich, Markus P. A1 - Smith, Wayne A1 - Magnusson, Martin A1 - Wentzel, Annemarie A1 - Myburgh, Carlien E. A1 - Steyn, Hendrik S. A1 - Malan, Nico T. T1 - Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study JF - Cardiovascular Journal of Africa Y1 - 2020 U6 - http://dx.doi.org/10.5830/CVJA-2020-031 SN - 1680-0745 VL - 26 IS - 31 SP - 1 EP - 12 PB - Clinics Cardive Publishing CY - Durbanville ER - TY - JOUR A1 - Maggakis-Kelemen, Christina A1 - Digel, Ilya A1 - Artmann, Gerhard T1 - Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility JF - Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1 Y1 - 2005 SP - 324 EP - 326 ER - TY - JOUR A1 - Maggakis-Kelemen, Christina A1 - Biselli, Manfred A1 - Artmann, Gerhard T1 - Determination of the elastic shear modulus of cultured human red blood cells JF - Biomedizinische Technik. 47 (2002), H. Suppl. 1 Pt. 1 Y1 - 2002 SN - 0013-5585 N1 - Druckausgabe unter 63 Z 471 vorhanden SP - 106 EP - 109 ER - TY - JOUR A1 - Lüth, H. A1 - Thust, M. A1 - Steffen, A. A1 - Kordos, P. A1 - Schöning, Michael Josef T1 - Biochemical sensors with structured and porous silicon capacitors JF - Materials Science and Engineering B. 69-70 (2000) Y1 - 2000 SN - 0921-5107 SP - 104 EP - 108 ER - TY - JOUR A1 - Lustfeld, H. A1 - Pithan, C. A1 - Reißel, Martin T1 - Metallic electrolyte composites in the framework of the brick-layer model JF - Journal of the European Ceramic Society N2 - It is well known that the already large dielectric constants of some electrolytes like BaTiO₃ can be enhanced further by adding metallic (e.g. Ni, Cu or Ag) nanoparticles. The enhancement can be quite large, a factor of more than 1000 is possible. The consequences for the properties will be discussed in the present paper applying a brick-layer model (BLM) for calculating dc-resistivities of thin layers and a modified one (PBLM) that includes percolation for calculating dielectric properties of these materials. The PBLM results in an at least qualitative description and understanding of the physical phenomena: This model gives an explanation for the steep increase of the dielectric constant below the percolation threshold and why this increase is connected to a dramatic decrease of the breakdown voltage as well as the ability of storing electrical energy. We conclude that metallic electrolyte composites like BaTiO₃ are not appropriate for energy storage. Y1 - 2012 U6 - http://dx.doi.org/10.1016/j.jeurceramsoc.2011.10.017 SN - 0955-2219 VL - 32 IS - 4 SP - 859 EP - 864 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Lustfeld, H. A1 - Hirschfeld, J. A. A1 - Reißel, Martin A1 - Steffen, B. T1 - Enhancement of precision and reduction of measuring points in tomographic reconstructions JF - Physics Letters A Y1 - 2011 SN - 0375-9601 VL - 375 IS - 8 SP - 1167 EP - 1171 PB - Elsevier CY - Amsterdam ER -