TY  - JOUR
A1  - Scheer, Nico
A1  - Wolf, C. Roland
T1  - Xenobiotic receptor humanized mice and their utility
JF  - Drug Metabolism Reviews
Y1  - 2013
U6  - https://doi.org/10.3109/03602532.2012.738687
SN  - 1097-9883
IS  - 1
SP  - 110
EP  - 121
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Wilson, Ian D.
T1  - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
JF  - Drug Discovery Today
N2  - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.
Y1  - 2016
U6  - https://doi.org/10.1016/j.drudis.2015.09.002
SN  - 1359-6446
VL  - 21
IS  - 2
SP  - 250
EP  - 263
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Snaith, Mike
A1  - Wolf, C. Roland
A1  - Seibler, Jost
T1  - Generation and utility of genetically humanized mouse models
JF  - Drug Discovery Today
Y1  - 2013
U6  - https://doi.org/10.1016/j.drudis.2013.07.007
SN  - 1359-6446
VL  - Vol 18
IS  - 23-24
SP  - 1200
EP  - 1211
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Ross, Jillian
A1  - Rode, Anja
A1  - Zevnik, Branko
A1  - Niehaves, Sandra
A1  - Faust, Nicole
A1  - Wolf, C. Roland
T1  - A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
JF  - Journal of Clinical Investigation
Y1  - 2008
U6  - https://doi.org/https://doi.org/10.1172/JCI35483
SN  - 1558-8238
VL  - 118
IS  - 9
SP  - 3228
EP  - 3239
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Ross, Jillian
A1  - Kapelyukh, Yury
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice
JF  - Drug Metabolism and Disposition
N2  - Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.
Y1  - 2010
U6  - https://doi.org/10.1124/dmd.109.031872
SN  - 1521-009X
VL  - 38
IS  - 7
SP  - 1046
EP  - 1053
PB  - ASPET
CY  - Bethesda
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Riedl, Iris
A1  - Warren, J.T.
A1  - Kuwada, John Y.
A1  - Campos-Ortega, José A.
T1  - A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish
JF  - Mechanism of Development
Y1  - 2002
U6  - https://doi.org/10.1016/S0925-4773(01)00621-9
SN  - 0925-4773
VL  - 112
IS  - 1-2
SP  - 9
EP  - 14
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Mclaughlin, Lesley A.
A1  - Rode, Anja
A1  - MacLeod, Alastair Kenneth
A1  - Henderson, Colin J.
A1  - Wolf, Roland C.
T1  - Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism
JF  - Drug Metabolism and Disposition
N2  - In humans, 75% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15%) and larger livers (20%). Changes in hepatic morphology and a decreased blood glucose (30%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.
Y1  - 2014
U6  - https://doi.org/10.1124/dmd.114.057885
SN  - 1521-009X
VL  - 42
IS  - 6
SP  - 1022
EP  - 1030
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - Rode, Anja
A1  - Oswald, Stefan
A1  - Busch, Diana
A1  - Mclaughlin, Lesley A.
A1  - Lin, De
A1  - Henderson, Colin J.
A1  - Wolf, C. Roland
T1  - Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model
JF  - Drug Metabolism and Disposition
Y1  - 2015
U6  - https://doi.org/10.1124/dmd.115.065656
SN  - 1521-009x
VL  - 43
IS  - 11
SP  - 1679
EP  - 1690
PB  - ASPET
CY  - Bethesda
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - Rode, Anja
A1  - Buechel, Sandra
A1  - Wolf, C. Roland
T1  - Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines
JF  - Molecular Pharmacology
N2  - Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.112.080036
SN  - 1521-0111
VL  - 82
IS  - 6
SP  - 1022
EP  - 1029
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Kapelyukh, Yury
A1  - McEwan, Jillian
A1  - Beuger, Vincent
A1  - Stanley, Lesley A.
A1  - Rode, Anja
A1  - Wolf, C. Roland
T1  - Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines
JF  - Molecular Pharmacology
N2  - The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.
Y1  - 2012
U6  - https://doi.org/10.1124/mol.111.075192
SN  - 1521-0111
VL  - 81
IS  - 1
SP  - 63
EP  - 72
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Henderson, Colin James
A1  - Kapelyukh, Yury
A1  - Rode, Anja
A1  - Mclaren, Aileen W.
A1  - MacLeod, Alastair Kenneth
A1  - Lin, De
A1  - Wright, Jayne
A1  - Stanley, Lesley
A1  - Wolf, C. Roland
T1  - An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials
JF  - Drug Metabolism and Disposition
Y1  - 2019
U6  - https://doi.org/10.1124/dmd.119.086397
IS  - Early view
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Groth, Anne
A1  - Hans, Stefan
A1  - Campos-Ortega, José A.
T1  - An instructive function for Notch in promoting gliogenesis in the zebrafish retina
JF  - Development
Y1  - 2001
SN  - 0950-1991
VL  - 128
IS  - 7
SP  - 1099
EP  - 1107
ER  - 
TY  - CHAP
A1  - Scheer, Nico
A1  - Chu, Xiaoyan
A1  - Salphati, Laurent
A1  - Zamek-Gliszczynski, Maciej J.
ED  - Nicholls, Glynis
T1  - Knockout and humanized animal models to study membrane transporters in drug development
T2  - Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development
Y1  - 2016
SN  - 978-1-78262-379-3
U6  - https://doi.org/10.1039/9781782623793-00298
SP  - 298
EP  - 332
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Campos-Ortega, José A.
T1  - Use of the Gal4-UAS technique for targeted gene expression in the zebrafish
JF  - Mechanism of Development
Y1  - 1999
U6  - https://doi.org/10.1016/S0925-4773(98)00209-3
SN  - 0925-4773
VL  - 80
IS  - 2
SP  - 153
EP  - 158
ER  - 
TY  - JOUR
A1  - Scheer, Nico
A1  - Balimane, Praveen
A1  - Hayward, Michael D.
A1  - Buechel, Sandra
A1  - Kauselmann, Gunther
A1  - Wolf, C. Roland
T1  - Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
JF  - Drug Metabolism and Disposition
N2  - The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(−/−)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(−/−) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.
Y1  - 2012
U6  - https://doi.org/10.1124/dmd.112.047605
SN  - 1521-0111
VL  - 40
IS  - 11
SP  - 2212
EP  - 2218
PB  - ASPET
CY  - Bethesda, Md.
ER  - 
TY  - JOUR
A1  - Scheele, Sandra
A1  - Oertel, Dan
A1  - Bongaerts, Johannes
A1  - Evers, Stefan
A1  - Hellmuth, Hendrik
A1  - Maurer, Karl-Heinz
A1  - Bott, Michael
A1  - Freudl, Roland
T1  - Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol–xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum
JF  - Microbial biotechnology
Y1  - 2013
SN  - 1751-7915
SP  - 202
EP  - 206
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Schartner, Karl-Heinz
A1  - Loeb, H. W.
A1  - Dachwald, Bernd
A1  - Ohndorf, Andreas
T1  - Perspectives of electric propulsion for outer planetary and deep space missions
T2  - European Planetary Science Congress 2009
N2  - Solar-electric propulsion (SEP) is superior with
respect to payload capacity, flight time and
flexible launch window to the conventional
interplanetary transfer method using chemical
propulsion combined with gravity assists. This fact
results from the large exhaust velocities of electric
low–thrust propulsion and is favourable also for
missions to the giant planets, Kuiper-belt objects
and even for a heliopause probe (IHP) as shown in
three studies by the authors funded by DLR. They
dealt with a lander for Europa and a sample return
mission from a mainbelt asteroid [1], with the
TANDEM mission [2]; the third recent one
investigates electric propulsion for the transfer to
the edge of the solar system.
All studies are based on triple-junction solar arrays,
on rf-ion thrusters of the qualified RIT-22 type and
they use the intelligent trajectory optimization
program InTrance [3].
Y1  - 2009
N1  - European Planetary Science Congress 2009, 13-18 September, Potsdam, Germany
SP  - 416
EP  - 416
ER  - 
TY  - JOUR
A1  - Schael, S.
A1  - Atanasyan, A.
A1  - Berdugo, J.
A1  - Bretz, T.
A1  - Czupalla, Markus
A1  - Dachwald, Bernd
A1  - Doetinchem, P. von
A1  - Duranti, M.
A1  - Gast, H.
A1  - Karpinski, W.
A1  - Kirn, T.
A1  - Lübelsmeyer, K.
A1  - Maña, C.
A1  - Marrocchesi, P.S.
A1  - Mertsch, P.
A1  - Moskalenko, I.V.
A1  - Schervan, T.
A1  - Schluse, M.
A1  - Schröder, K.-U.
A1  - Schultz von Dratzig, A.
A1  - Senatore, C.
A1  - Spies, L.
A1  - Wakely, S.P.
A1  - Wlochal, M.
A1  - Uglietti, D.
A1  - Zimmermann, J.
T1  - AMS-100: The next generation magnetic spectrometer in space – An international science platform for physics and astrophysics at Lagrange point 2
JF  - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Y1  - 2019
U6  - https://doi.org/10.1016/j.nima.2019.162561
SN  - 0168-9002
VL  - 944
IS  - 162561
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schaefer, Thomas
A1  - Höfken, Hans-Wilhelm
A1  - Schuba, Marko
T1  - Windows Phone 7 from a Digital Forensics’ Perspective
Y1  - 2011
N1  - ICDF2C <3, 2011, Dublin>
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Sawada, Kazuaki
A1  - Nakazawa, Hirokazu
A1  - Takenaga, Shoko
A1  - Hizawa, Takeshi
A1  - Futagawa, Masato
A1  - Dasai, Fumihiro
A1  - Sakurai, Takashi
A1  - Okumura, Koichi
A1  - Hattori, Toshiaki
A1  - Ishida, Makoto
T1  - Multimodal bioimage sensor
JF  - IEICE transactions on fundamentals of electronics, communidations and computer sciences
N2  - To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.
Y1  - 2014
U6  - https://doi.org/10.1587/transfun.E97.A.726
SN  - 0916-8508 (Print) ; 1745-1337 (Online)
VL  - E97-A (2014)
IS  - 3
SP  - 726
EP  - 733
PB  - IEICE
CY  - Tokyo
ER  - 
TY  - JOUR
A1  - Savitskaya, Irina
A1  - Zhantlessova, Sirina
A1  - Kistaubayeva, Aida
A1  - Ignatova, Ludmila
A1  - Shokatayeva, Dina
A1  - Sinyavsky, Yuriy
A1  - Kushugulova, Almagul
A1  - Digel, Ilya
T1  - Prebiotic cellulose–pullulan matrix as a “vehicle” for probiotic biofilm delivery to the host large intestine
JF  - Polymers
N2  - This study describes the development of a new combined polysaccharide-matrix-based technology for the immobilization of Lactobacillus rhamnosus GG (LGG) bacteria in biofilm form. The new composition allows for delivering the bacteria to the digestive tract in a manner that improves their robustness compared with planktonic cells and released biofilm cells. Granules consisting of a polysaccharide matrix with probiotic biofilms (PMPB) with high cell density (>9 log CFU/g) were obtained by immobilization in the optimized nutrient medium. Successful probiotic loading was confirmed by fluorescence microscopy and scanning electron microscopy. The developed prebiotic polysaccharide matrix significantly enhanced LGG viability under acidic (pH 2.0) and bile salt (0.3%) stress conditions. Enzymatic extract of feces, mimicking colon fluid in terms of cellulase activity, was used to evaluate the intestinal release of probiotics. PMPB granules showed the ability to gradually release a large number of viable LGG cells in the model colon fluid. In vivo, the oral administration of PMPB granules in rats resulted in the successful release of probiotics in the colon environment. The biofilm-forming incubation method of immobilization on a complex polysaccharide matrix tested in this study has shown high efficacy and promising potential for the development of innovative biotechnologies.
KW  - immobilization
KW  - prebiotic
KW  - bacterial cellulose
KW  - biofilms
KW  - Lactobacillus rhamnosus GG
Y1  - 2023
U6  - https://doi.org/10.3390/polym16010030
N1  - This article belongs to the Section "Polymer Composites and Nanocomposites"
IS  - 16(1)
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Savitskaya, Irina S.
A1  - Kistaubayeva, Aida S.
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Zhubanova, Azhar A.
T1  - Performance of Bio-Composite Carbonized Materials in Probiotic Applications
T2  - World Academy of Science, Engineering and Technology International Journal of Biotechnology and Bioengineering
Y1  - 2013
VL  - 7
IS  - 7
SP  - 685
EP  - 689
ER  - 
TY  - CHAP
A1  - Savitskaya, Irina S.
A1  - Kistaubayeva, Aida S.
A1  - Akimbekov, Nuraly S.
A1  - Digel, Ilya
A1  - Shokatayeva, Dina
A1  - Zhubanova, Azhar Achmet
T1  - Prospective Use of Probiotics Immobilized on Sorbents with Nanostructured Surfaces
T2  - Carbon Nanomaterials in Biomedicine and the Environment
N2  - Activated carbons are known as excellent adsorbents. Their applications include the adsorptive removal of color, odor, taste, undesirable organic and inorganic pollutants from drinking and waste water; air purification in inhabited spaces; purification of many chemicals, pharmaceutical products and many others. This chapter elucidates the role of normal microflora in the maintenance of human health and presents materials on possible clinical displays of microecological infringements and ways of their correction. It presents new developments concerning new probiotics with immobilized Lactobacillus and Bacillus. The chapter considers the mechanisms of the intestine disbacteriosis correction by sorbed probiotics. It demonstrates the advantages and creation prospects of immobilized probiotics developed on the basis of carbonized rice husk. There are great prospects for the development of medical biotechnology due to use of carbon sorbents with a nanostructured surface. Microbial communities form a biocenosis of the biotope and together with the host organism create permanent or temporary ecosystems.
Y1  - 2020
SN  - 978-981-4800-27-3
U6  - https://doi.org/10.1201/9780429428647-12
SP  - 229
EP  - 267
PB  - Jenny Stanford Publishing
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Savitskaya, I.S.
A1  - Kistaubayeva, A.S.
A1  - Ignatova, L.V.
A1  - Digel, Ilya
T1  - Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
JF  - Heliyon
Y1  - 2019
U6  - https://doi.org/10.1016/j.heliyon.2019.e02592
SN  - 2405-8440
VL  - 5
IS  - 10
SP  - Artikelnummer e02592
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Savitskaya, I. S.
A1  - Kistaubayeva, A. S.
A1  - Digel, Ilya
A1  - Shokatayeva, D. H.
T1  - Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials
JF  - Eurasian Chemico-Technological Journal
Y1  - 2017
U6  - https://doi.org/10.18321/ectj670
SN  - 2522-4867
VL  - 19
IS  - 3
SP  - 255
EP  - 264
ER  - 
TY  - CHAP
A1  - Sauerborn, Markus
A1  - Liebenstund, Lena
A1  - Raue, Markus
A1  - Mang, Thomas
A1  - Herrmann, Ulf
A1  - Dueing, Andreas
T1  - Analytic method for material aging and quality analyzing to forecast long time stability of plastic micro heliostat components
T2  - AIP Conference Proceedings
Y1  - 2017
U6  - https://doi.org/10.1063/1.4984388
VL  - 1850
IS  - 1
SP  - 030045-1
EP  - 030045-8
ER  - 
TY  - CHAP
A1  - Sauerborn, Markus
A1  - Klimek, J.
A1  - Hoffschmidt, Bernhard
A1  - Essen, H.
A1  - Sieger, S.
A1  - Biegel, G.
A1  - Göttsche, Joachim
A1  - Hilger, Patrick
T1  - Eurosun 2012 : radar technology for heliostat posititon control
T2  - Eurosun 2012 : Solar energy for a brighter future : conference proceedings : Rijeka, 18.-22.09.2012
Y1  - 2012
SP  - ID 80
CY  - Rijeka
ER  - 
TY  - CHAP
A1  - Sauerborn, Markus
A1  - Hoffschmidt, Bernhard
A1  - Telle, R.
A1  - Wagner, M.
T1  - Heatable optical analyse system for high temperature absorbers
T2  - 30th ISES Biennial Solar World Congress 2011 : : Kassel, Germany, 28 August - 2 September 2011. Vol. 5
Y1  - 2012
SN  - 978-1-61839-364-7
SP  - 3852
EP  - 3860
PB  - Curran
CY  - Red Hook, NY
ER  - 
TY  - CHAP
A1  - Sauerborn, Markus
A1  - Arshadi, S.
A1  - Rohrmoser, R.
T1  - Influence of clouds and aerosols to the haze of the sunshape
T2  - 30th ISES Biennial Solar World Congress 2011 : Kassel, Germany, 28 August - 2 September 2011. Vol. 5
Y1  - 2012
SP  - 3887
EP  - 3894
PB  - Curran
CY  - Red Hook, NY
ER  - 
TY  - CHAP
A1  - Sauerborn, Markus
T1  - Investigations to the influence of clouds and aerosols to the haze of the sunshape
T2  - SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain
Y1  - 2011
CY  - Granada
ER  - 
TY  - CHAP
A1  - Sattler, Johannes Christoph
A1  - Schneider, Iesse Peer
A1  - Angele, Florian
A1  - Atti, Vikrama
A1  - Teixeira Boura, Cristiano José
A1  - Herrmann, Ulf
T1  - Development of heliostat field calibration methods: Theory and experimental test results
T2  - SolarPACES 2022 conference proceedings
N2  - In this work, three patent pending calibration methods for heliostat fields of central receiver systems (CRS) developed by the Solar-Institut Jülich (SIJ) of the FH Aachen University of Applied Sciences are presented. The calibration methods can either operate in a combined mode or in stand-alone mode. The first calibration method, method A, foresees that a camera matrix is placed into the receiver plane where it is subjected to concentrated solar irradiance during a measurement process. The second calibration method, method B, uses an unmanned aerial vehicle (UAV) such as a quadrocopter to automatically fly into the reflected solar irradiance cross-section of one or more heliostats (two variants of method B were tested). The third calibration method, method C, foresees a stereo central camera or multiple stereo cameras installed e.g. on the solar tower whereby the orientations of the heliostats are calculated from the location detection of spherical red markers attached to the heliostats. The most accurate method is method A which has a mean accuracy of 0.17 mrad. The mean accuracy of method B variant 1 is 1.36 mrad and of variant 2 is 1.73 mrad. Method C has a mean accuracy of 15.07 mrad. For method B there is great potential regarding improving the measurement accuracy. For method C the collected data was not sufficient for determining whether or not there is potential for improving the accuracy.
KW  - Heliostat Field Calibration
KW  - Unmanned aerial vehicle
KW  - UAV
KW  - Quadrocopter
KW  - Camera system
Y1  - 2024
U6  - https://doi.org/10.52825/solarpaces.v1i.678
SN  - 2751-9899 (online)
N1  - SolarPACES 2022: 28th International Conference on Concentrating Solar Power and Chemical Energy Systems, 27-30 September, Albuquerque, NM, USA
IS  - 1
PB  - TIB Open Publishing
CY  - Hannover
ER  - 
TY  - JOUR
A1  - Sattler, Johannes Christoph
A1  - Röger, Marc
A1  - Schwarzbözl, Peter
A1  - Buck, Reiner
A1  - Macke, Ansgar
A1  - Raeder, Christian
A1  - Göttsche, Joachim
T1  - Review of heliostat calibration and tracking control methods
JF  - Solar Energy
N2  - Large scale central receiver systems typically deploy between thousands to more than a hundred thousand heliostats. During solar operation, each heliostat is aligned individually in such a way that the overall surface normal bisects the angle between the sun’s position and the aim point coordinate on the receiver. Due to various tracking error sources, achieving accurate alignment ≤1 mrad for all the heliostats with respect to the aim points on the receiver without a calibration system can be regarded as unrealistic. Therefore, a calibration system is necessary not only to improve the aiming accuracy for achieving desired flux distributions but also to reduce or eliminate spillage. An overview of current larger-scale central receiver systems (CRS), tracking error sources and the basic requirements of an ideal calibration system is presented. Leading up to the main topic, a description of general and specific terms on the topics heliostat calibration and tracking control clarifies the terminology used in this work. Various figures illustrate the signal flows along various typical components as well as the corresponding monitoring or measuring devices that indicate or measure along the signal (or effect) chain. The numerous calibration systems are described in detail and classified in groups. Two tables allow the juxtaposition of the calibration methods for a better comparison. In an assessment, the advantages and disadvantages of individual calibration methods are presented.
Y1  - 2020
U6  - https://doi.org/10.1016/j.solener.2020.06.030
VL  - 207
SP  - 110
EP  - 132
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Sattler, Johannes Christoph
A1  - Chico Caminos, Ricardo Alexander
A1  - Ürlings, Nicolas
A1  - Dutta, Siddharth
A1  - Ruiz, Victor
A1  - Kalogirou, Soteris
A1  - Ktistis, Panayiotis
A1  - Agathokleous, Rafaela
A1  - Jung, Christian
A1  - Alexopoulos, Spiros
A1  - Atti, Vikrama Nagababu
A1  - Teixeira Boura, Cristiano José
A1  - Herrmann, Ulf
T1  - Operational experience and behaviour of a parabolic trough collector system with concrete thermal energy storage for process steam generation in Cyprus
T2  - AIP Conference Proceedings
N2  - As part of the transnational research project EDITOR, a parabolic trough collector system (PTC) with concrete thermal energy storage (C-TES) was installed and commissioned in Limassol, Cyprus. The system is located on the premises of the beverage manufacturer KEAN Soft Drinks Ltd. and its function is to supply process steam for the factory's pasteurisation process [1]. Depending on the factory's seasonally varying capacity for beverage production, the solar system delivers between 5 and 25 % of the total steam demand. In combination with the C-TES, the solar plant can supply process steam on demand before sunrise or after sunset. Furthermore, the C-TES compensates the PTC during the day in fluctuating weather conditions. The parabolic trough collector as well as the control and oil handling unit is designed and manufactured by Protarget AG, Germany. The C-TES is designed and produced by CADE Soluciones de Ingeniería, S.L., Spain. In the focus of this paper is the description of the operational experience with the PTC, C-TES and boiler during the commissioning and operation phase. Additionally, innovative optimisation measures are presented.
Y1  - 2020
U6  - https://doi.org/10.1063/5.0029278
N1  - SOLARPACES 2019: International Conference on Concentrating Solar Power and Chemical Energy Systems, 1–4 October 2019, Daegu, South Korea
IS  - 2303
SP  - 140004-1
EP  - 140004-10
ER  - 
TY  - CHAP
A1  - Sattler, Johannes Christoph
A1  - Atti, Vikrama
A1  - Alexopoulos, Spiros
A1  - Teixeira Boura, Cristiano José
A1  - Herrmann, Ulf
A1  - Dutta, Siddharth
A1  - Kioutsioukis, Ioannis
T1  - DNI forecast tool for the smart operation of a parabolic trough collector system with concrete thermal energy storage: Theory, results and outlook
T2  - SolarPACES 2022 conference proceedings
N2  - This work presents a basic forecast tool for predicting direct normal irradiance (DNI) in hourly resolution, which the Solar-Institut Jülich (SIJ) is developing within a research project. The DNI forecast data shall be used for a parabolic trough collector (PTC) system with a concrete thermal energy storage (C-TES) located at the company KEAN Soft Drinks Ltd in Limassol, Cyprus. On a daily basis, 24-hour DNI prediction data in hourly resolution shall be automatically produced using free or very low-cost weather forecast data as input. The purpose of the DNI forecast tool is to automatically transfer the DNI forecast data on a daily basis to a main control unit (MCU). The MCU automatically makes a smart decision on the operation mode of the PTC system such as steam production mode and/or C-TES charging mode. The DNI forecast tool was evaluated using historical data of measured DNI from an on-site weather station, which was compared to the DNI forecast data. The DNI forecast tool was tested using data from 56 days between January and March 2022, which included days with a strong variation in DNI due to cloud passages. For the evaluation of the DNI forecast reliability, three categories were created and the forecast data was sorted accordingly. The result was that the DNI forecast tool has a reliability of 71.4 % based on the tested days. The result fulfils SIJ’s aim to achieve a reliability of around 70 %, but SIJ aims to still improve the DNI forecast quality.
KW  - Direct normal irradiance forecast
KW  - DNI forecast
KW  - Parabolic trough collector
KW  - PTC
KW  - Thermal Energy Storage
Y1  - 2024
U6  - https://doi.org/10.52825/solarpaces.v1i.731
SN  - 2751-9899 (online)
N1  - SolarPACES 2022, 28th International Conference on Concentrating Solar Power and Chemical Energy Systems, 27-30 September, Albuquerque, NM, USA
IS  - 1
PB  - TIB Open Publishing
CY  - Hannover
ER  - 
TY  - CHAP
A1  - Sattler, Johannes Christoph
A1  - Alexopoulos, Spiros
A1  - Chico Caminos, Ricardo Alexander
A1  - Mitchell, John C.
A1  - Ruiz, Victor C.
A1  - Kalogirou, Soteris
A1  - Ktistis, Panayiotis K.
A1  - Teixeira Boura, Cristiano José
A1  - Herrmann, Ulf
T1  - Dynamic simulation model of a parabolic trough collector system with concrete thermal energy storage for process steam generation
T2  - AIP Conference Proceedings
Y1  - 2019
U6  - https://doi.org/10.1063/1.5117663
SN  - 0094243X
VL  - 2126
SP  - 150007-1
EP  - 150007-8
ER  - 
TY  - JOUR
A1  - Saretzki, Charlotte
A1  - Bergmann, Ole
A1  - Dahmann, Peter
A1  - Janser, Frank
A1  - Keimer, Jona
A1  - Machado, Patricia
A1  - Morrison, Audry
A1  - Page, Henry
A1  - Pluta, Emil
A1  - Stübing, Felix
A1  - Küpper, Thomas
T1  - Are small airplanes safe with regards to COVID-19 transmission?
JF  - Journal of Travel Medicine
Y1  - 2021
U6  - https://doi.org/10.1093/jtm/taab105
SN  - 1708-8305
VL  - 28
IS  - 7
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - RPRT
A1  - Sansom, M.
A1  - Lawson, R.M.
A1  - Tucho, R.
A1  - Kendrick, C.
A1  - Ogden, R.
A1  - Resalati, S.
A1  - Garay, R.
A1  - Döring, Bernd
A1  - Reger, V.
A1  - Gilbert, J.
A1  - Heikkinen, J.
A1  - Hemmila, K.
T1  - Building in active thermal mass into steel structures (BATIMASS) - EUR 28166EN
N2  - The main objective of the BATIMASS project was to address how the energy balance in relatively lightweight steel buildings can be improved by building in ‘active thermal mass’ (ATM) into the building fabric. This was achieved through concept design, dynamic thermal modelling and testing of a number of potentially viable systems and concepts. A significant programme of thermal simulation modelling was undertaken utilising the thermally equivalent slab (TES) concept to model the passive thermal capacity effect of profiled, composite metal floor decks. It is apparent from the modelling results that thermal mass is a highly complex phenomenon which is highly dependent upon building type, occupancy patterns, climate and many other aspects of the building design and servicing strategy. The ATM systems developed, both conceptually and for prototype testing, focussed on water-cooled composite slabs, the Cofradal floor system and the phase change material (PCM) Energain. In addition to laboratory testing of prototypes, whole building monitoring was undertaken at the Kubik building in Spain and the RWTH test building in Germany. Advanced thermal modelling was also undertaken to estimate the likely benefits of the ATM concept designs developed and for comparison with the test results. In addition to thermal testing, structural tests were conducted on composite floor specimens incorporating embedded water pipes. This Final Report presents the results of the activities carried out under this RFCS contract RFSR CT 2012 00033. The work carried out is reported in six major sections corresponding to the technical Work Packages of the project. Only summaries of the work carried out are provided in this report; all work undertaken is fully reported in the formal project deliverables.
KW  - industrial research
KW  - iron and steel industry
KW  - research project
KW  - materials technology
KW  - resistance of materials
KW  - steel
KW  - metal structure
KW  - ingot
KW  - building industry
KW  - research report
Y1  - 2016
SN  - 978-92-79-63176-4
U6  - https://doi.org/10.2777/25999
SN  - 1831-9424
PB  - Publications Office of the European Union
CY  - Luxembourg
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Roy, Alain
T1  - GARA: A Uniform Quality of Service Architecture / Roy, Alain ; Sander, Volker
JF  - Grid resource management : state of the art and future trends / ed. by Jarek Nabrzyski; Jennifer M. Schopf; Jan W&#796;eglarz
Y1  - 2004
SN  - 1-4020-7575-8
N1  - International series in operations research & management science ; 64
SP  - 377
EP  - 394
PB  - Kluwer Academic Publ.
CY  - Boston
ER  - 
TY  - BOOK
A1  - Sander, Volker
A1  - Roy, Alain
T1  - Advance Reservation API / Roy, Alain ; Sander, Volker
Y1  - 2002
N1  - GFD-E.5 Scheduling Working Group Category: Experimental
PB  - Global Grid Forum
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Foster, Ian T.
A1  - Fidler, Markus
A1  - Roy, Alain
T1  - End-to-end quality of service for high-end applications / Foster, Ian T. ; Fidler, Markus ; Roy, Alain ; Sander, Volker ; Winkler, Linda
JF  - Computer Communications. 27 (2004), H. 14
Y1  - 2004
SN  - 0140-3664
SP  - 1375
EP  - 1388
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Foster, Ian
A1  - Roy, Alain
A1  - Winkler, Linda
T1  - A differentiated services implementation for high-performance TCP flows
JF  - Computer Networks. 34 (2000), H. 6
Y1  - 2000
SN  - 1389-1286
SP  - 915
EP  - 929
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Fidler, Markus
A1  - Klimala, Wojciech
T1  - Traffic shaping in aggregate-based networks: implementation and analysis / Fidler, Markus ; Sander, Volker ; Klimala, Wojciech
JF  - Computer Communications. 28 (2005), H. 3
Y1  - 2005
SN  - 0140-3664
SP  - 274
EP  - 286
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Fidler, Markus
T1  - A parameter based admission control for differentiated services networks / Fidler, Markus ; Sander, Volker
JF  - Computer Networks. 44 (2004), H. 4
Y1  - 2004
SN  - 1389-1286
SP  - 463
EP  - 479
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Erwin, Dietmar
A1  - Huber, Valentina
T1  - High-performance computer management based on Java
JF  - Future Generation Computer Systems. 15 (1999), H. 3
Y1  - 1999
SN  - 0167-739X
SP  - 425
EP  - 432
ER  - 
TY  - JOUR
A1  - Sander, Volker
A1  - Czajkowski, K.
A1  - Foster, I.
A1  - Kesselman, C.
T1  - SNAP: A Protocol for Negotiating Service Level Agreements and Coordinating Resource Management in Distributed Systems / Czajkowski, K. ; Foster, I. ; Kesselman, C. ; Sander, V. ; Tuecke, S.
JF  - Job Scheduling Strategies for Parallel Processing : 8th InternationalWorkshop, JSSPP 2002 Edinburgh, Scotland, UK, July 24, 2002. Revised Papers
Y1  - 2002
SN  - 3-540-00172-7
N1  - Lecture Notes in Computer Science ; 2537 ; JSSPP <8, 2002, Edinburgh >
SP  - 153
EP  - 183
PB  - Springer
CY  - Berlin
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Design and evaluation of a bandwidth broker that provides network quality of service for grid applications
Y1  - 2003
SN  - 3-00-010002-4
N1  - NIC series ; 16 ; Zugl. Aachen, Techn. Hochsch., Diss., 2002
PB  - John von Neumann Institute for Computing (NIC)
CY  - Jülich
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Optical Network Infrastructure for Grid / Simeonidou, Dimitra ... (ed.)
Y1  - 2004
N1  - GFD-I.036 Category: Informational ; GHPN-RG
PB  - Global Grid Forum
ER  - 
TY  - BOOK
A1  - Sander, Volker
T1  - Networking Issues for Grid Infrastructure / Sander, Volker  (ed.)
Y1  - 2004
N1  - GFD-I.037 Category: Informational ; Grid High Performance Networking Research Group
PB  - Global Grid Forum
ER  - 
TY  - CHAP
A1  - Samuelsson, K.
A1  - Scheer, Nico
A1  - Wilson, I.
A1  - Wolf, C.R.
A1  - Henderson, C.J.
ED  - Chackalamannil, Samuel
T1  - Genetically Humanized Animal Models
T2  - Comprehensive Medicinal Chemistry III. 3rd Edition
N2  - Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
KW  - Chimeric liver-humanized mice
KW  - Drug distribution
KW  - Drug metabolism
KW  - Toxicology
KW  - Knockout mice
Y1  - 2017
SN  - 978-0-12-803201-5
U6  - https://doi.org/10.1016/B978-0-12-409547-2.12376-5
SP  - 130
EP  - 149
PB  - Elsevier
CY  - Saint Louis
ER  - 
TY  - JOUR
A1  - Samm, Doris
A1  - Faissner, H.
A1  - Moers, T.
A1  - Priem, R.
T1  - Modular wall-less drift chamber for muon detection at the LHC / H. Faissner, Th. Moers, R. Priem, ... , D. Samm [u.a.]
JF  - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 330 (1993), H. 1-2
Y1  - 1993
SP  - 76
EP  - 82
ER  -