TY - JOUR A1 - Salpati, Laurent A1 - Chu, Xiaoyan A1 - Chen, Liangfu A1 - Prasad, Bhagwat A1 - Dallas, Shannon A1 - Evers, Raymond A1 - Mamaril-Fishman, Donna A1 - Geier, Ethan G. A1 - Kehler, Jonathan A1 - Kunta, Jeevan A1 - Mezler, Mario A1 - Laplanche, Loic A1 - Pang, Jodie A1 - Soars, Matthew G. A1 - Unadkat, Jashvant D. A1 - van Waterschoot, Robert A.B. A1 - Yabut, Jocelyn A1 - Schinkel, Alfred H. A1 - Scheer, Nico A1 - Rode, Anja T1 - Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins JF - Drug Metabolism and Disposition N2 - Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography–tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans. Y1 - 2014 U6 - https://doi.org/10.1124/dmd.114.057976 SN - 1521-009X VL - 42 IS - 8 SP - 1301 EP - 1313 PB - ASPET CY - Bethesda, Md. ER - TY - CHAP A1 - Sakthivel, Mariappan A1 - Weppner, Werner T1 - Response behaviour of a hydrogen sensor based on ionic conducting polymer-metal interfaces prepared by the chemical reduction method N2 - A solid-state amperometric hydrogen sensor based on a protonated Nafion membrane and catalytic active electrode operating at room temperature was fabricated and tested. Ionic conducting polymer-metal electrode interfaces were prepared chemically by using the impregnation-reduction method. The polymer membrane was impregnated with tetra-ammine platinum chloride hydrate and the metal ions were subsequently reduced by using either sodium tetrahydroborate or potassium tetrahydroborate. The hydrogen sensing characteristics with air as reference gas is reported. The sensors were capable of detecting hydrogen concentrations from 10 ppm to 10% in nitrogen. The response time was in the range of 10-30 s and a stable linear current output was observed. The thin Pt films were characterized by XRD, Infrared Spectroscopy, Optical Microscopy, Atomic Force Microscopy, Scanning Electron Microscopy and EDAX. KW - Biosensor KW - Hydrogen sensor KW - amperometric sensor KW - porous Pt electrode KW - chemical reduction method Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:hbz:a96-opus-1399 ER - TY - CHAP A1 - Sajatovic, Miodrag A1 - Rihacek, Christoph A1 - Haindl, Bernhard A1 - Schnell, Michael A1 - Brandes, Sinja A1 - Gligorevic, Snjezana T1 - Broadband VHF (B-VHF) project achievements and follow-on activities T2 - Integrated Communications, Navigation and Surveillance Conference : Herndon, VA, 1 - 3 May 2007 Y1 - 2007 SN - 1-4244-1216-1 SP - 1 EP - 8 ER - TY - JOUR A1 - Sadykov, Rustam A1 - Digel, Ilya A1 - Temiz Artmann, Aysegül A1 - Porst, Dariusz A1 - Linder, Peter A1 - Kayser, Peter A1 - Artmann, Gerhard A1 - Savitskaya, Irina A1 - Zhubanova, Azhar T1 - Oral lead exposure induces dysbacteriosis in rats JF - Journal of Occupational Health. 51 (2009) (2009), H. 1 Y1 - 2009 SN - 1348-9585 SP - 64 EP - 73 ER - TY - CHAP A1 - Sadeghfam, Arash A1 - Sadeghi-Ahangar, A. A1 - Elgamal, Abdelrahman A1 - Heuermann, Holger T1 - Design and Development of a Novel Self-Igniting Microwave Plasma Jet for Industrial Applications T2 - IEEE MTT-S International Microwave Symposium Digest Y1 - 2019 SN - 978-172811309-8 SP - 63 EP - 66 ER - TY - JOUR A1 - Sabitova, A. A1 - Ebert, Ph. A1 - Lenz, A. A1 - Schaafhausen, S. A1 - Ivanova, L. A1 - Dähne, M. A1 - Hoffmann, A. A1 - Dunin-Borkowski, R. E. A1 - Förster, Arnold A1 - Grandidier, B. A1 - Eisele, H. T1 - Intrinsic bandgap of cleaved ZnO(112¯0) surfaces JF - Applied physics letters Y1 - 2013 SN - 1077-3118 (E-Journal); 0003-6951 (Print) VL - Vol. 102 SP - 021608 ER - TY - CHAP A1 - Rütters, René A1 - Weinheimer, Marius A1 - Bragard, Michael T1 - Teaching Control Theory with a Simplified Helicopter Model and a Classroom Fitting Hardware Test-Bench T2 - 2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON) Y1 - 2018 SN - 978-1-5386-6903-7 U6 - https://doi.org/10.1109/RTUCON.2018.8659871 ER - TY - CHAP A1 - Rütters, René A1 - Bragard, Michael A1 - Dolls, Sarah T1 - The Inverted Rotary Pendulum: Facilitating Practical Teaching in Advanced Control Engineering T2 - 2024 IEEE Global Engineering Education Conference (EDUCON) N2 - This paper outlines a practical approach to teach control engineering principles, with an inverted rotary pendulum, serving as an illustrative example. It shows how the pendulum is embedded in an advanced course of control engineering. This approach is incorporated into a flipped-classroom concept, as well as classical teaching concepts, offering students practical experience in control engineering. In addition, the design of the pendulum is shown, using a Raspberry Pi as the target platform for Matlab Simulink. This pendulum can be used in the classroom to evaluate the controller design mentioned above. It is analysed if the use of the pendulum generates a deeper understanding of the learning contents. KW - Matlab KW - Engineering education KW - Online services KW - Software packages KW - Electronic learning KW - Control engineering Y1 - 2024 U6 - https://doi.org/10.1109/EDUCON60312.2024.10578937 SN - 2165-9559 SN - 2165-9567 (eISSN) N1 - 2024 IEEE Global Engineering Education Conference (EDUCON), 08-11 May 2024, Kos Island, Greece PB - IEEE CY - New York, NY ER - TY - JOUR A1 - Rübbelke, Dirk A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Zobel, Luzy T1 - Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production JF - Data in Brief N2 - Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (Rübbelke, 2022). KW - Energy-intensive industry KW - Steel industry KW - Competitiveness KW - Floor prices KW - Cross border adjustment mechanism Y1 - 2023 U6 - https://doi.org/10.1016/j.dib.2023.108907 SN - 2352-3409 VL - 47 IS - Article 108907 SP - 1 EP - 5 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rübbelke, Dirk A1 - Vögele, Stefan A1 - Grajewski, Matthias A1 - Zobel, Luzy T1 - Hydrogen-based steel production and global climate protection: An empirical analysis of the potential role of a European cross border adjustment mechanism JF - Journal of Cleaner Production N2 - The European Union's aim to become climate neutral by 2050 necessitates ambitious efforts to reduce carbon emissions. Large reductions can be attained particularly in energy intensive sectors like iron and steel. In order to prevent the relocation of such industries outside the EU in the course of tightening environmental regulations, the establishment of a climate club jointly with other large emitters and alternatively the unilateral implementation of an international cross-border carbon tax mechanism are proposed. This article focuses on the latter option choosing the steel sector as an example. In particular, we investigate the financial conditions under which a European cross border mechanism is capable to protect hydrogen-based steel production routes employed in Europe against more polluting competition from abroad. By using a floor price model, we assess the competitiveness of different steel production routes in selected countries. We evaluate the climate friendliness of steel production on the basis of specific GHG emissions. In addition, we utilize an input-output price model. It enables us to assess impacts of rising cost of steel production on commodities using steel as intermediates. Our results raise concerns that a cross-border tax mechanism will not suffice to bring about competitiveness of hydrogen-based steel production in Europe because the cost tends to remain higher than the cost of steel production in e.g. China. Steel is a classic example for a good used mainly as intermediate for other products. Therefore, a cross-border tax mechanism for steel will increase the price of products produced in the EU that require steel as an input. This can in turn adversely affect competitiveness of these sectors. Hence, the effects of higher steel costs on European exports should be borne in mind and could require the cross-border adjustment mechanism to also subsidize exports. Y1 - 2022 U6 - https://doi.org/10.1016/j.jclepro.2022.135040 SN - 0959-6526 VL - 380 IS - Part 2, Art. Nr.:135040 PB - Elsevier ER - TY - JOUR A1 - Röthenbacher, Annika A1 - Cesari, Matteo A1 - Doppler, Christopher E.J. A1 - Okkels, Niels A1 - Willemsen, Nele A1 - Sembowski, Nora A1 - Seger, Aline A1 - Lindner, Marie A1 - Brune, Corinna A1 - Stefani, Ambra A1 - Högl, Birgit A1 - Bialonski, Stephan A1 - Borghammer, Per A1 - Fink, Gereon R. A1 - Schober, Martin A1 - Sommerauer, Michael T1 - RBDtector: an open-source software to detect REM sleep without atonia according to visual scoring criteria JF - Scientific Reports N2 - REM sleep without atonia (RSWA) is a key feature for the diagnosis of rapid eye movement (REM) sleep behaviour disorder (RBD). We introduce RBDtector, a novel open-source software to score RSWA according to established SINBAR visual scoring criteria. We assessed muscle activity of the mentalis, flexor digitorum superficialis (FDS), and anterior tibialis (AT) muscles. RSWA was scored manually as tonic, phasic, and any activity by human scorers as well as using RBDtector in 20 subjects. Subsequently, 174 subjects (72 without RBD and 102 with RBD) were analysed with RBDtector to show the algorithm’s applicability. We additionally compared RBDtector estimates to a previously published dataset. RBDtector showed robust conformity with human scorings. The highest congruency was achieved for phasic and any activity of the FDS. Combining mentalis any and FDS any, RBDtector identified RBD subjects with 100% specificity and 96% sensitivity applying a cut-off of 20.6%. Comparable performance was obtained without manual artefact removal. RBD subjects also showed muscle bouts of higher amplitude and longer duration. RBDtector provides estimates of tonic, phasic, and any activity comparable to human scorings. RBDtector, which is freely available, can help identify RBD subjects and provides reliable RSWA metrics. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-25163-9 SN - 2045-2322 VL - 12 IS - Article number: 20886 SP - 1 EP - 14 PB - Springer Nature CY - London ER - TY - JOUR A1 - Rösch, C. A1 - Kratz, F. A1 - Hering, T. A1 - Trautmann, S. A1 - Umanskaya, N. A1 - Tippkötter, Nils A1 - Müller-Renno, C.M. A1 - Ulber, Roland A1 - Hannig, M. A1 - Ziegler, C. T1 - Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity JF - Colloids and Surfaces B: Biointerfaces N2 - The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase. Y1 - 2016 U6 - https://doi.org/10.1016/j.colsurfb.2016.09.048 VL - 149 IS - 1 SP - 115 EP - 121 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Schöning, Michael Josef A1 - Selmer, Thorsten T1 - Development of an amperometric biosensor platform for the combined determination of l-Malic, Fumaric, and l-Aspartic acid JF - Applied Biochemistry and Biotechnology N2 - Three amperometric biosensors have been developed for the detection of L-malic acid, fumaric acid, and L -aspartic acid, all based on the combination of a malate-specific dehydrogenase (MDH, EC 1.1.1.37) and diaphorase (DIA, EC 1.8.1.4). The stepwise expansion of the malate platform with the enzymes fumarate hydratase (FH, EC 4.2.1.2) and aspartate ammonia-lyase (ASPA, EC 4.3.1.1) resulted in multi-enzyme reaction cascades and, thus, augmentation of the substrate spectrum of the sensors. Electrochemical measurements were carried out in presence of the cofactor β-nicotinamide adenine dinucleotide (NAD+) and the redox mediator hexacyanoferrate (III) (HCFIII). The amperometric detection is mediated by oxidation of hexacyanoferrate (II) (HCFII) at an applied potential of + 0.3 V vs. Ag/AgCl. For each biosensor, optimum working conditions were defined by adjustment of cofactor concentrations, buffer pH, and immobilization procedure. Under these improved conditions, amperometric responses were linear up to 3.0 mM for L-malate and fumarate, respectively, with a corresponding sensitivity of 0.7 μA mM−1 (L-malate biosensor) and 0.4 μA mM−1 (fumarate biosensor). The L-aspartate detection system displayed a linear range of 1.0–10.0 mM with a sensitivity of 0.09 μA mM−1. The sensor characteristics suggest that the developed platform provides a promising method for the detection and differentiation of the three substrates. Y1 - 2017 U6 - https://doi.org/10.1007/s12010-017-2578-1 SN - 1559-0291 VL - 183 SP - 566 EP - 581 PB - Springer CY - Berlin ER - TY - JOUR A1 - Röhlen, Desiree A1 - Pilas, Johanna A1 - Dahmen, Markus A1 - Keusgen, Michael A1 - Selmer, Thorsten A1 - Schöning, Michael Josef T1 - Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes JF - Frontiers in Chemistry N2 - Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes. Y1 - 2018 U6 - https://doi.org/10.3389/fchem.2018.00284 IS - 6 PB - Frontiers CY - Lausanne ER - TY - JOUR A1 - Rupp, Matthias A1 - Schulze, Sven A1 - Kuperjans, Isabel T1 - Comparative life cycle analysis of conventional and hybrid heavy-duty trucks JF - World electric vehicle journal N2 - Heavy-duty trucks are one of the main contributors to greenhouse gas emissions in German traffic. Drivetrain electrification is an option to reduce tailpipe emissions by increasing energy conversion efficiency. To evaluate the vehicle’s environmental impacts, it is necessary to consider the entire life cycle. In addition to the daily use, it is also necessary to include the impact of production and disposal. This study presents the comparative life cycle analysis of a parallel hybrid and a conventional heavy-duty truck in long-haul operation. Assuming a uniform vehicle glider, only the differing parts of both drivetrains are taken into account to calculate the environmental burdens of the production. The use phase is modeled by a backward simulation in MATLAB/Simulink considering a characteristic driving cycle. A break-even analysis is conducted to show at what mileage the larger CO2eq emissions due to the production of the electric drivetrain are compensated. The effect of parameter variation on the break-even mileage is investigated by a sensitivity analysis. The results of this analysis show the difference in CO2eq/t km is negative, indicating that the hybrid vehicle releases 4.34 g CO2eq/t km over a lifetime fewer emissions compared to the diesel truck. The break-even analysis also emphasizes the advantages of the electrified drivetrain, compensating the larger emissions generated during production after already a distance of 15,800 km (approx. 1.5 months of operation time). The intersection coordinates, distance, and CO2eq, strongly depend on fuel, emissions for battery production and the driving profile, which lead to nearly all parameter variations showing an increase in break-even distance. Y1 - 2018 U6 - https://doi.org/10.3390/wevj9020033 SN - 2032-6653 VL - 9 IS - 2 SP - Article No. 33 PB - MDPI CY - Basel ER - TY - JOUR A1 - Rupp, Matthias A1 - Rieke, Christian A1 - Handschuh, Nils A1 - Kuperjans, Isabel T1 - Economic and ecological optimization of electric bus charging considering variable electricity prices and CO₂eq intensities JF - Transportation Research Part D: Transport and Environment N2 - In many cities, diesel buses are being replaced by electric buses with the aim of reducing local emissions and thus improving air quality. The protection of the environment and the health of the population is the highest priority of our society. For the transport companies that operate these buses, not only ecological issues but also economic issues are of great importance. Due to the high purchase costs of electric buses compared to conventional buses, operators are forced to use electric vehicles in a targeted manner in order to ensure amortization over the service life of the vehicles. A compromise between ecology and economy must be found in order to both protect the environment and ensure economical operation of the buses. In this study, we present a new methodology for optimizing the vehicles’ charging time as a function of the parameters CO₂eq emissions and electricity costs. Based on recorded driving profiles in daily bus operation, the energy demands of conventional and electric buses are calculated for the passenger transportation in the city of Aachen in 2017. Different charging scenarios are defined to analyze the influence of the temporal variability of CO₂eq intensity and electricity price on the environmental impact and economy of the bus. For every individual day of a year, charging periods with the lowest and highest costs and emissions are identified and recommendations for daily bus operation are made. To enable both the ecological and economical operation of the bus, the parameters of electricity price and CO₂ are weighted differently, and several charging periods are proposed, taking into account the priorities previously set. A sensitivity analysis is carried out to evaluate the influence of selected parameters and to derive recommendations for improving the ecological and economic balance of the battery-powered electric vehicle. In all scenarios, the optimization of the charging period results in energy cost savings of a maximum of 13.6% compared to charging at a fixed electricity price. The savings potential of CO₂eq emissions is similar, at 14.9%. From an economic point of view, charging between 2 a.m. and 4 a.m. results in the lowest energy costs on average. The CO₂eq intensity is also low in this period, but midday charging leads to the largest savings in CO₂eq emissions. From a life cycle perspective, the electric bus is not economically competitive with the conventional bus. However, from an ecological point of view, the electric bus saves on average 37.5% CO₂eq emissions over its service life compared to the diesel bus. The reduction potential is maximized if the electric vehicle exclusively consumes electricity from solar and wind power. Y1 - 2020 U6 - https://doi.org/10.1016/j.trd.2020.102293 SN - 1361-9209 VL - 81 IS - Article 102293 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Rupp, Matthias A1 - Handschuh, Nils A1 - Rieke, Christian A1 - Kuperjans, Isabel T1 - Contribution of country-specific electricity mix and charging time to environmental impact of battery electric vehicles: A case study of electric buses in Germany JF - Applied Energy Y1 - 2019 U6 - https://doi.org/10.1016/j.apenergy.2019.01.059 SN - 0306-2619 VL - 237 SP - 618 EP - 634 PB - Elsevier CY - Amsterdam ER - TY - CHAP A1 - Rousseau, Alain A1 - Kern, Alexander T1 - How to deal with environmental risk in IEC 62305-2 T2 - 2014 International Conference on Lightning Protection (ICLP), Shanghai, China N2 - The 2nd edition of the lightning risk management standard (IEC 62305-2) considers structures, which may endanger environment. In these cases, the loss is not limited to the structure itself, which is valid for usual structures. In the past (Edition 1) this danger was simply taken into account by a special hazard factor, multiplying the existing risk for the structure with a number. Now, in the edition 2, we add to the risk for the structure itself a “second risk” due to the losses outside the structure. The losses outside can be treated independently from what occurs inside. This is a major advantage to analyze the risk for sensitive structures, like chemical plants, nuclear plants, or structures containing explosives, etc. In this paper, the existing procedure given by the European version EN 62305-2 Ed.2 is further developed and applied to a few structures. Y1 - 2014 SP - 521 EP - 527 ER - TY - GEN A1 - Rothkranz, Berit A1 - Krafft, Simone A1 - Tippkötter, Nils T1 - Media optimization for sustainable fuel production: How to produce biohydrogen from renewable resources with Thermotoga neapolitana T2 - Chemie Ingenieur Technik N2 - Hydrogen is playing an increasingly important role in research and politics as an energy carrier of the future. Since hydrogen has commonly been produced from methane by steam reforming, the need for climate-friendly, alternative production routes is emerging. In addition to electrolysis, fermentative routes for the production of so-called biohydrogen are "green" alternatives. The application of microorganisms offers the advantage of sustainable production from renewable resources using easily manageable technologies. In this project, the hyperthermophilic, anaerobic microorganism Thermotoga neapolitana is used for the productio nof biohydrogen from renewable resources. The enzymatically hydrolyzed resources were used in fermentation leading to yield coefficients of 1.8 mole H₂ per mole glucose when using hydrolyzed straw and ryegrass supplemented with medium, respectively. These results are similar to the hydrogen yields when using Thermotoga basal medium with glucose (TBGY) as control group. In order to minimize the supplementation of the hydrolysate and thus increase the economic efficiency of the process, the essential media components were identified. The experiments revealed NaCl, KCl, and glucose as essential components for cell growth as well as biohydrogen production. When excluding NaCl, a decrease of 96% in hydrogen production occured. Y1 - 2022 U6 - https://doi.org/10.1002/cite.202255305 SN - 0009-286X SN - 1522-2640 (eISSN) N1 - ProcessNet and DECHEMA‐BioTechNet Jahrestagungen 2022 together with 13th ESBES Symposium 2022, 12. - 15. September 2022, Eurogress Aachen VL - 94 IS - 9 SP - 1298 EP - 1299 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Roth, Jasmine A1 - Tippkötter, Nils T1 - Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium JF - Cellulose Chemistry and Technology N2 - Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹. Y1 - 2016 VL - 50 IS - 3-4 SP - 405 EP - 410 PB - Editura Academiei Romane CY - Bukarest ER - TY - GEN A1 - Roth, J. A1 - Tippkötter, Nils T1 - New Approach for Enzymatic Hydrolysis of Lignocellulose with Selective Diffusion Separation of the Monosaccharide Products T2 - Chemie Ingenieur Technik N2 - Enzymatic hydrolysis of lignocellulosic material plays an important role in the classical biorefinery approach. Apart from the pretreatment of the raw material, hydrolysis is the basis for the conversion of the cellulose and hemicellulose fraction into fermentable sugars. After hydrolysis, usually a solid-liquid separation takes place, in order to separate the residual plant material from the sugar-rich fraction, which can be subsequently used in a fermentation step. In order to factor out the separation step, the usage of in alginate immobilized crude cellulose fiber beads (CFBs) were evaluated. Pretreated cellulose fibers are incorporated in an alginate matrix together with the relevant enzymes. In doing so, sugars diffuse trough the alginate matrix, allowing a simplified delivery into the surrounding fluid. This again reduces product inhibition of the glucose on the enzyme catalysts. By means of standardized bead production the hydrolysis in lab scale was possible. First results show that liberation of glucose and xylose is possible, allowing a maximum total sugar yield of 75 %. Y1 - 2016 U6 - https://doi.org/10.1002/cite.201650301 SN - 0009-286X SN - 1522-2640 (eISSN) N1 - ProcessNet-Jahrestagung 2016 und 32. DECHEMA-Jahrestagung der Biotechnologen 2016, 12. - 15. September 2016, Eurogress Aachen VL - 88 IS - 9 SP - 1237 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Roth, J. A1 - Möhring, S. A1 - Tippkötter, Nils T1 - Characterization and evaluation of lignocellulosic biomass 130 hydrolysates for ABE fermentation T2 - New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany Y1 - 2016 SP - 130 PB - DECHEMA CY - Frankfurt am Main ER - TY - JOUR A1 - Rossi, Leonardo A1 - Winands, Mark H. M. A1 - Butenweg, Christoph ED - Zhang, Jessica T1 - Monte Carlo Tree Search as an intelligent search tool in structural design problems JF - Engineering with Computers : An International Journal for Simulation-Based Engineering N2 - Monte Carlo Tree Search (MCTS) is a search technique that in the last decade emerged as a major breakthrough for Artificial Intelligence applications regarding board- and video-games. In 2016, AlphaGo, an MCTS-based software agent, outperformed the human world champion of the board game Go. This game was for long considered almost infeasible for machines, due to its immense search space and the need for a long-term strategy. Since this historical success, MCTS is considered as an effective new approach for many other scientific and technical problems. Interestingly, civil structural engineering, as a discipline, offers many tasks whose solution may benefit from intelligent search and in particular from adopting MCTS as a search tool. In this work, we show how MCTS can be adapted to search for suitable solutions of a structural engineering design problem. The problem consists of choosing the load-bearing elements in a reference reinforced concrete structure, so to achieve a set of specific dynamic characteristics. In the paper, we report the results obtained by applying both a plain and a hybrid version of single-agent MCTS. The hybrid approach consists of an integration of both MCTS and classic Genetic Algorithm (GA), the latter also serving as a term of comparison for the results. The study’s outcomes may open new perspectives for the adoption of MCTS as a design tool for civil engineers. KW - Monte Carlo Tree Search KW - Structural design KW - Artificial intelligence KW - Civil engineering KW - Genetic algorithm Y1 - 2022 U6 - https://doi.org/10.1007/s00366-021-01338-2 SN - 1435-5663 SN - 0177-0667 VL - 38 IS - 4 SP - 3219 EP - 3236 PB - Springer Nature CY - Cham ER - TY - JOUR A1 - Rossi, Leonardo A1 - Stupazzini, Marco A1 - Parisi, Davide A1 - Holtschoppen, Britta A1 - Ruggieri, Gabriella A1 - Butenweg, Christoph T1 - Empirical fragility functions and loss curves for long-span-beam buildings based on the 2012 Emilia-Romagna earthquake official database JF - Bulletin of Earthquake Engineering N2 - The 2012 Emilia-Romagna earthquake, that mainly struck the homonymous Italian region provoking 28 casualties and damage to thousands of structures and infrastructures, is an exceptional source of information to question, investigate, and challenge the validity of seismic fragility functions and loss curves from an empirical standpoint. Among the most recent seismic events taking place in Europe, that of Emilia-Romagna is quite likely one of the best documented, not only in terms of experienced damages, but also for what concerns occurred losses and necessary reconstruction costs. In fact, in order to manage the compensations in a fair way both to citizens and business owners, soon after the seismic sequence, the regional administrative authority started (1) collecting damage and consequence-related data, (2) evaluating information sources and (3) taking care of the cross-checking of various reports. A specific database—so-called Sistema Informativo Gestione Europa (SFINGE)—was devoted to damaged business activities. As a result, 7 years after the seismic events, scientists can rely on a one-of-a-kind, vast and consistent database, containing information about (among other things): (1) buildings’ location and dimensions, (2) occurred structural damages, (3) experienced direct economic losses and (4) related reconstruction costs. The present work is focused on a specific data subset of SFINGE, whose elements are Long-Span-Beam buildings (mostly precast) deployed for business activities in industry, trade or agriculture. With the available set of data, empirical fragility functions, cost and loss ratio curves are elaborated, that may be included within existing Performance Based Earthquake Engineering assessment toolkits. KW - Empirical fragility functions KW - Empirical consequence curves KW - Precast buildings KW - Emilia-Romagna earthquake KW - PBEE Y1 - 2019 U6 - https://doi.org/10.1007/s10518-019-00759-1 SN - 1573-1456 VL - 18 SP - 1693 EP - 1721 PB - Springer Nature ER - TY - JOUR A1 - Rossi, Leonardo A1 - Parisi, Davide A1 - Casari, Chiara A1 - Montanari, Luca A1 - Ruggieri, Gabriella A1 - Holtschoppen, Britta A1 - Butenweg, Christoph T1 - Empirical Data about Direct Economic Consequences of Emilia-Romagna 2012 Earthquake on Long-Span-Beam Buildings JF - Earthquake Spectra Y1 - 2019 U6 - https://doi.org/10.1193/100118EQS224DP SN - 1944-8201 VL - 35 IS - 4 SP - 1979 EP - 2001 ER - TY - JOUR A1 - Rossi, Leonardo A1 - Holtschoppen, Britta A1 - Butenweg, Christoph T1 - Official data on the economic consequences of the 2012 Emilia-Romagna earthquake: a first analysis of database SFINGE JF - Bulletin of Earthquake Engineering Y1 - 2019 U6 - https://doi.org/10.1007%2Fs10518-019-00655-8 VL - 17 IS - 9 SP - 4855 EP - 4884 PB - Springer CY - Berlin ER - TY - GEN A1 - Ross-Jones, J. A1 - Teumer, T. A1 - Capitain, C. A1 - Tippkötter, Nils A1 - Krause, M. J. A1 - Methner, F.-J. A1 - Rädle, M. T1 - Analytical methods for in-line characterization of beer haze T2 - Trends in Brewing N2 - In most beers, producers strive to minimize haze to maximize visual appeal. To detect the formation of particulates, a measurement system for sub-micron particles is required. Beer haze is naturally occurring, composed of protein or polyphenol particles; in their early stage of growth their size is smaller than 2 µm. Microscopy analysis is time and resource intensive; alternatively, backscattering is an inexpensive option for detecting particle sizes of interest. Y1 - 2018 N1 - Trends in Brewing, April 8 –12, 2018, Ghent, Belgium ER - TY - JOUR A1 - Ross, Jillian A1 - Plummer, Simon M. A1 - Rode, Anja A1 - Scheer, Nico A1 - Bower, Conrad C. A1 - Vogel, Ortwin A1 - Henderson, Colin J. A1 - Wolf, C. Roland A1 - Elcombe, Clifford R. T1 - Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo JF - Toxicological Sciences N2 - Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel “humanized” and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained. Y1 - 2010 U6 - https://doi.org/10.1093/toxsci/kfq118 SN - 1096-0929 VL - 116 IS - 2 SP - 452 EP - 466 PB - Oxford University Press CY - Oxford ER - TY - CHAP A1 - Rosin, Julia A1 - Kubalski, Thomas A1 - Butenweg, Christoph T1 - Seismic Design of cylindrical liquid storage tanks T2 - Seismic design of industrial facilities : proceedings of the International Conference on Seismic Design of Industrial Facilities (SeDIF-Conference) ; [Aachen, 26. - 27. September 2013] / Chair of Structural Statics and Dynamics, RWTH Aachen. Sven Klinkel ..., ed. Y1 - 2014 SN - 978-3-658-02810-7 (E-Book) ; 978-3-658-02809-1 (Print) U6 - https://doi.org/10.1007/978-3-658-02810-7_36 SP - 429 EP - 440 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Rosin, Julia A1 - Kubalski, Thomas A1 - Butenweg, Christoph ED - Klinkel, Sven ED - Butenweg, Christoph ED - Lin, Gao ED - Holtschoppen, Britta T1 - Seismic isolation of cylindrical liquid storage tanks T2 - Seismic design of industrial facilities N2 - Seismic excited liquid filled tanks are subjected to extreme loading due to hydrodynamic pressures, which can lead to nonlinear stability failure of the thinwalled cylindrical tanks, as it is known from past earthquakes. A significant reduction of the seismically induced loads can be obtained by the application of base isolation systems, which have to be designed carefully with respect to the modified hydrodynamic behaviour of the tank in interaction with the liquid. For this reason a highly sophisticated fluid-structure interaction model has to be applied for a realistic simulation of the overall dynamic system. In the following, such a model is presented and compared with the results of simplified mathematical models for rigidly supported tanks. Finally, it is examined to what extent a simple mechanical model can represent the behaviour of a base isolated tank in case of seismic excitation Y1 - 2013 SN - 978-3-658-02810-7 SN - 978-3-658-02809-1 SN - 978-3-658-14037-3 U6 - https://doi.org/10.1007/978-3-658-02810-7_36 N1 - International Conference on Seismic Design of Industrial Facilities, Aachen, Germany, 26.-27.09.2013. https://sedif-conference.jimdofree.com/ SP - 429 EP - 440 PB - Springer Vieweg CY - Wiesbaden ER - TY - CHAP A1 - Rosin, Julia A1 - Henneböhl, Benedickt A1 - Butenweg, Christoph T1 - Global buckling analysis of cylindrical liquid storage tanks under earthquake loading T2 - 2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6 Y1 - 2014 SN - 978-1-5108-1021-1 SP - 5270 EP - 5281 PB - Curran Associates, Inc. CY - Red Hook, NY ER - TY - JOUR A1 - Rosin, Julia A1 - Butenweg, Christoph A1 - Cacciatore, Pamela A1 - Boesen, Niklas T1 - Investigation of the seismic performance of modern masonry buildings during the Emilia Romagna earthquake series T1 - Untersuchungen des seismischen Verhaltens von modernen Mauerwerksbauten während der Erdbebenserie in der Emilia Romagna JF - Mauerwerk N2 - The article presents the investigation of the seismic behaviour of a modern URM building located in the municipality of Finale Emilia in province of Modena, Northern Italy. The building is situated in the centre of the series of the 2012 Northern Italy earthquakes and has not suffered any damage during the earthquake series in 2012. The observed earthquake resistance of the building is compared with predicted resistances based on linear and nonlinear design approaches according to Eurocode. Furthermore, probabilistic analyses based on nonlinear calculation models taking into account scattering of the most relevant input parameters are carried out to identify their influence to the results and to derive fragility curves. Y1 - 2018 U6 - https://doi.org/10.1002/dama.201800013 SN - 1437-1022 VL - 22 IS - 4 SP - 238 EP - 250 PB - Ernst & Sohn CY - Berlin ER - TY - CHAP A1 - Rosin, Julia A1 - Butenweg, Christoph A1 - Boesen, Niklas A1 - Gellert, Christoph T1 - Evaluation of the Seismic Behavior of a Modern URM Building During the 2012 Northern Italy Earthquakes T2 - 16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018 Y1 - 2018 SP - 1 EP - 12 ER - TY - CHAP A1 - Rosin, Julia A1 - Butenweg, Christoph T1 - Seismic isolation of cylindrical liquid storage tanks T2 - Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.) Y1 - 2014 SN - 978-972-752-165-4 SP - 3145 EP - 3152 CY - Porto ER - TY - CHAP A1 - Rosin, J. A1 - Mykoniou, K. A1 - Butenweg, Christoph T1 - Analysis Of Base Isolated Liquid Storage Tanks With 3D Fsi-Analysis As Well As Simplified Approaches T2 - 16th World Conference on Earthquake Engineering, 16WCEE 2017 Santiago Chile, January 9th to 13th 2017 N2 - Tanks are preferably designed, for cost-saving reasons, as circular, cylindrical, thin-walled shells. In case of seismic excitation, these constructions are highly vulnerable to stability failures. An earthquake-resistant design of rigidly supported tanks for high seismic loading demands, however, uneconomic wall thicknesses. A cost-effective alternative can be provided by base isolation systems. In this paper, a simplified seismic design procedure for base isolated tanks is introduced, by appropriately modifying the standard mechanical model for flexible, rigidly supported tanks. The non-linear behavior of conventional base isolation systems becomes an integral part of a proposed simplified process, which enables the assessment of the reduced hydrodynamic forces acting on the tank walls and the corresponding stress distribution. The impulsive and convective actions of the liquid are taken into account. The validity of this approach is evaluated by employing a non-linear fluid-structure interaction algorithm of finite element method. Special focus is placed on the boundary conditions imposed from the base isolation and the resulting hydrodynamic pressures. Both horizontal and vertical component of ground motion are considered in order to study the principal effects of the base isolation on the pressure distribution of the tank walls. The induced rocking effects associated with elastomeric bearings are discussed. The results manifest that base isolated tanks can be designed for seismic loads by means of the proposed procedure with sufficient accuracy, allowing to dispense with numerically expensive techniques. KW - liquid storage tank KW - seismic isolation KW - elastomeric bearing KW - friction pendulum bearing KW - simplified approach Y1 - 2017 N1 - Paper No 2246 SP - 1 EP - 14 PB - Chilean Association on Seismology and Earthquake Engineering (ACHISINA) ER - TY - JOUR A1 - Rosenauer, A. A1 - Oberst, W. A1 - Litvinov, D. A1 - Gerthsen, D. A1 - Förster, Arnold A1 - Schmidt, R. T1 - Structural and Chemical Investigation of In-0.6Ga0.4As Stranski-Krastanow Layers Burried in GaAs by Transmission Electron Microscopy JF - Physical Review B. 61 (2000), H. 12 Y1 - 2000 SN - 1095-3795 SP - 8276 EP - 8288 ER - TY - CHAP A1 - Rosemann, Michael A1 - Eggert, Mathias A1 - Voigt, Matthias A1 - Beverungen, Daniel T1 - Leveraging Social Network Data for Analytical CRM Strategies - The Introduction of Social BI. T2 - ECIS 2012 Proceedings Y1 - 2012 N1 - European Conference on Information Systems (ECIS), 2012 ER - TY - CHAP A1 - Roosen, Petra A1 - Feyerl, Günter T1 - Gender-specific perception and utilization of personal use vehicles T2 - FISITA World Automotive Congress 2014 : Maastricht, The Netherlands, 2 - 6 June / [organised by the International Federation of Automotive Engineering Societies (FISITA) ...]. Bd. 1 Y1 - 2015 SN - 978-1-5108-0209-4 SP - 418 EP - 425 PB - Curran CY - Red Hook, NY ER - TY - JOUR A1 - Rolka, David A1 - Poghossian, Arshak A1 - Schöning, Michael Josef T1 - Integration of a capacitive EIS sensor into a FIA system for pH and penicillin determination JF - Sensors. 4 (2004) Y1 - 2004 SN - 1424-8220 SP - 84 EP - 94 ER - TY - CHAP A1 - Rokitansky, Carl-Herbert A1 - Ehammer, Max A1 - Gräupl, Thomas A1 - Schnell, Michael A1 - Brandes, Sinja A1 - Gligorevic, Snjezana A1 - Rihacek, Christoph A1 - Sajatovic, Miodrag T1 - B-AMC a system for future broadband aeronautical multi-carrier communications in the L-BAND T2 - IEEE/AIAA 26th Digital Avionics Systems Conference ; DASC '07 ; 21 - 25 Oct. 2007, Dallas, Texas Y1 - 2007 SN - 978-1-4244-1108-5 SP - 4D2-1 EP - 4D2-13 ER - TY - CHAP A1 - Rokitansky, Carl-Herbert A1 - Ehammer, Max A1 - Gräupl, Thomas A1 - Schnell, Michael A1 - Brandes, Sinja A1 - Gligorevic, Snjezana A1 - Rihacek, Christoph A1 - Sajatovic, Miodrag T1 - B-AMC – Aeronautical Broadband Communication in the L-Band T2 - First CEAS European Air and Space Conference : Motto: century perspectives : Deutscher Luft-und Raumfahrtkongress 2007 : 10-13 September 2007 in Berlin, Germany. (Jahrbuch der Deutschen Gesellschaft für Luft- und Raumfahrt 2007 ; Bd. 1-5. - Enth.: Jahrbuch der Deutschen Gesellschaft für Luft- und Raumfahrt 2006 ; Bd. 3) Y1 - 2007 SN - 0070-4083 SP - 487 EP - 496 PB - Deutschen Gesellschaft für Luft- und Raumfahrt CY - Bonn ER - TY - JOUR A1 - Roeth, A.A. A1 - Slabu, I. A1 - Kessler, A. A1 - Engelmann, Ulrich M. T1 - Local treatment of pancreatic cancer with magnetic nanoparticles JF - HPB Y1 - 2019 U6 - https://doi.org/10.1016/j.hpb.2019.10.959 SN - 1365-182X VL - 21 IS - Supplement 3 SP - S868 EP - S869 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Roesner, Andreas A1 - Scheik, Sven A1 - Olowinsky, Alexander A1 - Gillner, Arnold A1 - Reisgen, Uwe A1 - Schleser, Markus T1 - Laser assisted joining of plastic metal hybrids JF - Lasers in manufacturing 2011 : proceedings of the sixth International WLT Conference on Lasers in Manufacturing, Munich, May 23 - 26 2011. (Physics procedia ; Vol. 12 (2011), Part B) Y1 - 2011 SN - 1875-3892 (E-Journal); 1875-3884 (Print) SP - 370 EP - 377 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Roesner, Andreas A1 - Scheik, Sven A1 - Olowinsky, Alexander A1 - Gillner, Arnold A1 - Propawe, Reinhart A1 - Schleser, Markus A1 - Reisgen, Uwe T1 - Innovative approach of joining hybrid components JF - Journal of laser applications Y1 - 2011 SN - 1042-346X VL - Vol. 23 IS - Iss. 3 SP - 32007 PB - Laser Institute of America CY - Orlando, Fla. ER - TY - JOUR A1 - Roepke, Rene A1 - Köhler, Klemens A1 - Drury, Vincent A1 - Schroeder, Ulrik A1 - Wolf, Martin R. A1 - Meyer, Ulrike T1 - A pond full of phishing games - analysis of learning games for anti-phishing education JF - Model-driven Simulation and Training Environments for Cybersecurity. MSTEC 2020 N2 - Game-based learning is a promising approach to anti-phishing education, as it fosters motivation and can help reduce the perceived difficulty of the educational material. Over the years, several prototypes for game-based applications have been proposed, that follow different approaches in content selection, presentation, and game mechanics. In this paper, a literature and product review of existing learning games is presented. Based on research papers and accessible applications, an in-depth analysis was conducted, encompassing target groups, educational contexts, learning goals based on Bloom’s Revised Taxonomy, and learning content. As a result of this review, we created the publications on games (POG) data set for the domain of anti-phishing education. While there are games that can convey factual and conceptual knowledge, we find that most games are either unavailable, fail to convey procedural knowledge or lack technical depth. Thus, we identify potential areas of improvement for games suitable for end-users in informal learning contexts. Y1 - 2020 SN - 978-3-030-62433-0 U6 - https://doi.org/10.1007/978-3-030-62433-0_32020 N1 - Lecture Notes in Computer Science, vol 12512 SP - 41 EP - 60 PB - Springer CY - Cham ER - TY - JOUR A1 - Rodrigues, Raul T. A1 - Morais, Paulo V. A1 - Nordi, Cristina S. F. A1 - Schöning, Michael Josef A1 - Siqueira Jr., José R. A1 - Caseli, Luciano T1 - Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films JF - Langmuir N2 - Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air–water interface were investigated by surface pressure–area isotherms, surface potential–area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte–insulator–semiconductor (EIS) devices, through the Langmuir–Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV–vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme–lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance–voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications. Y1 - 2018 U6 - https://doi.org/10.1021/acs.langmuir.7b04317 SN - 1520-5827 VL - 34 IS - 9 SP - 3082 EP - 3093 PB - ACS Publications CY - Washington, DC ER - TY - CHAP A1 - Rochefort, E. de A1 - Verver, M. A1 - Grunendahl, A. A1 - Mooi, H. A1 - Butenweg, Christoph T1 - Detailed modelling of the lumbar spine for investigation of low back pain T2 - Digital Human Modeling for Design and Engineering Symposium : Iowa City, Iowa June 14-16, 2005. (SAE technical papers series ; 2005-1-2716) Y1 - 2005 U6 - https://doi.org/10.4271/2005-01-2716 SN - 0096-736X SP - 1 EP - 11 PB - SAE International CY - Warrendale, Pa. ER - TY - JOUR A1 - Rochefort, E. de A1 - Verver, M. A1 - Grunendahl, A. A1 - Mooi, H. A1 - Butenweg, Christoph T1 - Detailed modelling of the lumbar spine for investigations of low back pain JF - SAE transactions : papers presented at Society and Section meetings / Society of Automotive Engineers Y1 - 2005 SN - 0096-736X VL - Volume 114 IS - Part 7 SP - 788 EP - 796 ER - TY - JOUR A1 - Robinson, A. E. A1 - Rönna, Uwe A1 - Funke, Harald T1 - Testing of a 10 kW diffusive micro-mix combustor for hydrogen-fuelled micro-scale gas turbines JF - International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications <7, 2007, Freiburg, Breisgau> ; PowerMEMS ; 7 Y1 - 2007 SP - 225 EP - 228 ER - TY - JOUR A1 - Robinson, A. E. A1 - Funke, Harald A1 - Wagemakers, R. A1 - Grossen, J. A1 - Bosschaerts, W. A1 - Hendrick, P. T1 - Numerical and Experimental Investigation of a Micromix Combustor for a Hydrogen Fuelled μ-Scale Gas Turbine JF - Proceedings of the ASME Turbo Expo 2009 : : presented at the 2009 ASME Turbo Expo, June 8 - 12, 2009, Orlando, Florida, USA / sponsored by the International Gas Turbine Institute Y1 - 2009 SN - 9780791848869 N1 - GT2009-60061 SP - 253 EP - 262 PB - ASME CY - New York, NY ER -