TY  - JOUR
A1  - Werfel, Stanislas
A1  - Günthner, Roman
A1  - Hapfelmeier, Alexander
A1  - Hanssen, Henner
A1  - Kotliar, Konstantin
A1  - Heemann, Uwe
A1  - Schmaderer, Christoph
ED  - Guzik, Tomasz J.
T1  - Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning
JF  - Cardiovascular Research
N2  - Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.
KW  - Machine learning
KW  - Retinal vessels
KW  - Microcirculation
KW  - Haemodialysis
KW  - Myocardial infarction and cardiac death
Y1  - 2022
U6  - http://dx.doi.org/10.1093/cvr/cvab040
SN  - 0008-6363
VL  - 118
IS  - 2
SP  - 612
EP  - 621
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - CHAP
A1  - Wendorff, Marion
A1  - Eggert, Thorsten
A1  - Pohl, Martina
A1  - Dresen, Carola
A1  - Müller, Michael
A1  - Jaeger, Karl-Erich
A1  - Sprenger, Georg A.
A1  - Schürmann, Melanie
A1  - Schürmann, Martin
A1  - Johnen, Sandra
A1  - Sprenger, Gerda
A1  - Sahm, Hermann
A1  - Inoue, Tomoyuki
A1  - Schörken, Ulrich
A1  - Breittaupt, Holger
A1  - Frölich, Bettina
A1  - Heim, Petra
A1  - Iding, Hans
A1  - Juchem, Bettina
A1  - Siegert, Petra
A1  - Kula, Maria-Regina
A1  - Weckbecker, Andrea
A1  - Hummel, Werner
A1  - Fessner, Wolf-Dieter
A1  - Elling, Lothar
A1  - Wolberg, Michael
A1  - Bode, Silke
A1  - Feldmann, Ralf
A1  - Geilenkirchen, Petra
A1  - Schubert, Thomas
A1  - Walter, Lydia
A1  - Dünnwald, Thomas
A1  - Demir, Ayhan S.
A1  - Kolter-Jung, Doris
A1  - Nitsche, Adam
A1  - Dünkelmann, Pascal
A1  - Cosp, Annabel
A1  - Lingen, Bettina
T1  - Catalytic asymmetric synthesis : section 2.2
T2  - Asymmetric synthesis with chemical and biological methods / ed. by Dieter Enders ...
Y1  - 2007
SN  - 978-3-527-31473-7
SP  - 298
EP  - 413
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Wendlandt, Tim
A1  - Koch, Claudia
A1  - Britz, Beate
A1  - Liedek, Anke
A1  - Schmidt, Nora
A1  - Werner, Stefan
A1  - Gleba, Yuri
A1  - Vahidpour, Farnoosh
A1  - Welden, Melanie
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
T1  - Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System
JF  - Viruses
N2  - Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes.
KW  - biosensor
KW  - horseradish peroxidase (HRP)
KW  - glucose oxidase (GOx)
KW  - enzyme cascade
KW  - turnip vein clearing virus (TVCV)
KW  - tobacco mosaic virus (TMV)
Y1  - 2023
U6  - http://dx.doi.org/doi.org/10.3390/v15091951
SN  - 1999-4915
N1  - This article belongs to the Special Issue "Tobamoviruses 2023"
VL  - 9
IS  - 15
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Wemhöner, Carsten
A1  - Hafner, Bernd
A1  - Schwarzer, Klemens
T1  - Simulation of solar thermal systems with CARNOT blockset in the environment MATLAB-Simulink
Y1  - 2000
SP  - 1
EP  - 6
ER  - 
TY  - CHAP
A1  - Wellmer, Georg
A1  - Chen, B.-H.
A1  - Braun, Carsten
A1  - Ballmann, Josef
T1  - Numerical prediction of aeroelastic effects on twin-sting-rig mounted models for rear fuselage and empennage flow investigation in transonic windtunnel
T2  - Proceedings / IFASD 2007, CEAS/AIAA/KTH International Forum on Aeroelasticity and Structural Dynamics, June 18 - 21, 2007, Stockholm, Sweden
Y1  - 2007
PB  - KTH
CY  - Stockholm
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick H.
A1  - Wagner, Torsten
T1  - Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions
JF  - Sensors
N2  - In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor–electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types.
Y1  - 2020
U6  - http://dx.doi.org/10.3390/s20061680
SN  - 1424-8220
VL  - 20
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Scheja, Sabrina
A1  - Schöning, Michael Josef
A1  - Wagner, Patrick
A1  - Wagner, Torsten
T1  - Electrochemical Evaluation of Light‐Addressable Electrodes Based on TiO2 for the Integration in Lab‐on‐Chip Systems
JF  - physica status solidi a : applications and materials sciences
N2  - In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol–gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated.
Y1  - 2018
U6  - http://dx.doi.org/10.1002/pssa.201800150
SN  - 1862-6319
VL  - 215
IS  - 15
SP  - Article number 1800150
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Nagamine Komesu, Cindy A.
A1  - Wagner, Patrick H.
A1  - Schöning, Michael Josef
A1  - Wagner, Torsten
T1  - Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment
JF  - Electrochemical Science Advances
N2  - Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin.
KW  - enzymatic biosensor
KW  - penicillin
KW  - penicillinase
KW  - photoelectrochemistry
KW  - titanium dioxide photoanode
Y1  - 2021
U6  - http://dx.doi.org/10.1002/elsa.202100131
SN  - 2698-5977
N1  - Corresponding auhtor: Michael J. Schöning
VL  - 2
IS  - 4
SP  - 1
EP  - 5
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Welden, Rene
A1  - Jablonski, Melanie
A1  - Wege, Christina
A1  - Keusgen, Michael
A1  - Wagner, Patrick Hermann
A1  - Wagner, Torsten
A1  - Schöning, Michael Josef
T1  - Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase
JF  - Biosensors
N2  - The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte’s pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS.
KW  - microfluidics
KW  - enzyme kinetics
KW  - actuator-sensor system
KW  - light-addressable electrode
KW  - light-addressable potentiometric sensor
Y1  - 2021
U6  - http://dx.doi.org/10.3390/bios11060171
SN  - 2079-6374
N1  - This article belongs to the Special Issue "Selected Papers from the 1st International Electronic Conference on Biosensors (IECB 2020)"
VL  - 11
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Welden, Melanie
A1  - Severins, Robin
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Siegert, Petra
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors
T2  - 2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN)
N2  - A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy.
KW  - Tobacco mosaic virus
KW  - acetoin
KW  - capacitive field-effect biosensor
KW  - enzyme immobilization
Y1  - 2022
SN  - 978-1-6654-5860-3 (Online)
SN  - 978-1-6654-5861-0 (Print)
U6  - http://dx.doi.org/10.1109/ISOEN54820.2022.9789657
N1  - IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 29 May 2022 - 01 June 2022, Aveiro, Portugal.
PB  - IEEE
ER  - 
TY  - JOUR
A1  - Welden, Melanie
A1  - Severins, Robin
A1  - Poghossian, Arshak
A1  - Wege, Christina
A1  - Bongaerts, Johannes
A1  - Siegert, Petra
A1  - Keusgen, Michael
A1  - Schöning, Michael Josef
T1  - Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor
JF  - Chemosensors
N2  - Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte–insulator–semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin–streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage–current, capacitance–voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.
Y1  - 2022
U6  - http://dx.doi.org/10.3390/chemosensors10060218
SN  - 2227-9040
N1  - This article belongs to the Special Issue "Nanostructured Devices for Biochemical Sensing"
VL  - 10
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Welden, Melanie
A1  - Poghossian, Arshak
A1  - Vahidpour, Farnoosh
A1  - Wendlandt, Tim
A1  - Keusgen, Michael
A1  - Wege, Christina
A1  - Schöning, Michael Josef
T1  - Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers
JF  - Biosensors
N2  - Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1–3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.
KW  - urease
KW  - enzyme-logic gate
KW  - bi-enzyme biosensor
KW  - capacitive field-effect sensor
KW  - tobacco mosaic virus (TMV)
KW  - penicillinase
Y1  - 2022
U6  - http://dx.doi.org/10.3390/bios12010043
SN  - 2079-6374
N1  - This article belongs to the Special Issue "Biosensors: 10th Anniversary Feature Papers"
VL  - 12
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - CHAP
A1  - Weiss, Christian
A1  - Heslenfeld, Jonas
A1  - Saewe, Jasmin Kathrin
A1  - Bremen, Sebastian
A1  - Häfner, Constantin Leon
T1  - Investigation on the influence of powder humidity in Laser Powder Bed Fusion (LPBF)
T2  - Procedia CIRP
N2  - In the Laser Powder Bed Fusion (LPBF) process, parts are built out of metal powder material by exposure of a laser beam. During handling operations of the powder material, several influencing factors can affect the properties of the powder material and therefore directly influence the processability during manufacturing. Contamination by moisture due to handling operations is one of the most critical aspects of powder quality. In order to investigate the influences of powder humidity on LPBF processing, four materials (AlSi10Mg, Ti6Al4V, 316L and IN718) are chosen for this study. The powder material is artificially humidified, subsequently characterized, manufactured into cubic samples in a miniaturized process chamber and analyzed for their relative density. The results indicate that the processability and reproducibility of parts made of AlSi10Mg and Ti6Al4V are susceptible to humidity, while IN718 and 316L are barely influenced.
KW  - LPBF
KW  - Additive Manufacturing
KW  - Powder Material
KW  - Humidity
Y1  - 2022
U6  - http://dx.doi.org/10.1016/j.procir.2022.08.102
SN  - 2212-8271
N1  - Teil der Sonderausgabe: 12th CIRP Conference on Photonic Technologies [LANE 2022]
VL  - 111
SP  - 115
EP  - 120
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Weiss, Alexander
A1  - Abanteriba, Sylvester
A1  - Esch, Thomas
T1  - Investigation of Flow Separation Inside a Conical Rocket Nozzle With the Aid of an Annular Cross Flow
T2  - Proceedings of the ASME/JSME 2007 5th Joint Fluids Engineering Conference. Volume 1: Symposia, Parts A and B
N2  - Flow separation is a phenomenon that occurs in all kinds of supersonic nozzles sometimes during run-up and shut-down operations. Especially in expansion nozzles of rocket engines with large area ratio, flow separation can trigger strong side loads that can damage the structure of the nozzle. The investigation presented in this paper seeks to establish measures that may be applied to alter the point of flow separation. In order to achieve this, a supersonic nozzle was placed at the exit plane of the conical nozzle. This resulted in the generation of cross flow surrounding the core jet flow from the conical nozzle. Due to the entrainment of the gas stream from the conical nozzle the pressure in its exit plane was found to be lower than that of the ambient. A Cold gas instead of hot combustion gases was used as the working fluid. A mathematical simulation of the concept was validated by experiment. Measurements confirmed the simulation results that due to the introduction of a second nozzle the pressure in the separated region of the conical nozzle was significantly reduced. It was also established that the boundary layer separation inside the conical nozzle was delayed thus allowing an increased degree of overexpansion. The condition established by the pressure measurements was also demonstrated qualitatively using transparent nozzle configurations.
Y1  - 2007
SN  - 0-7918-4288-6
U6  - http://dx.doi.org/10.1115/FEDSM2007-37387
N1  - Proceedings of the ASME/JSME 2007 5th Joint Fluids Engineering Conference. Volume 1: Symposia, Parts A and B. San Diego, California, USA. July 30–August 2, 2007
SP  - 1861
EP  - 1871
PB  - American Society of Mechanical Engineers (ASME)
CY  - New York
ER  - 
TY  - CHAP
A1  - Weil, M.
A1  - Poghossian, Arshak
A1  - Schöning, Michael Josef
A1  - Cherstvy, A.
T1  - Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices
Y1  - 2012
SN  - 978-3-9813484-2-2
U6  - http://dx.doi.org/10.5162/IMCS2012/P2.5.2
SP  - 1575
EP  - 1578
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
A1  - Collani, E. v.
A1  - Saniga, E.M.
T1  - Economic Adjustment Design for -Control Charts. E.v.Collani, E.M. Saniga, Ch. Weigand
JF  - IIE Transactions / Institute of Industrial Engineers. 26 (1994), H. 6
Y1  - 1994
SN  - 0569-5554
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Optimal Production Schedule for a K Products Single Machine Problem
JF  - Economic Quality Control. 9 (1994)
Y1  - 1994
SN  - 0940-5151
SP  - 91
EP  - 101
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - A Solution to the Scheduling Problem Taking into Account Quality
JF  - Operations research '91 : extended abstracts of the 16th Symposium on Operations Research held at the University of Trier at September 9 - 11, 1991 / [GMÖOR]. Peter Gritzmann ... (eds.)
Y1  - 1991
SN  - 3790806080
N1  - Symposium on Operations Research ; (16, 1991, Trier)
SP  - 373
EP  - 375
PB  - Physica-Verl.
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Optimal Adjustment Policies
JF  - Proceedings of the First Umeå-Würzburg Conference in Statistics : Kronlund Conference Center and University of Umeå, September 10 - 14, 1990 / ed. by Kurt Brännäs
Y1  - 1990
SN  - 91-7174-564-5
N1  - Umeå-Würzburg Conference in Statistics <1, 1990>
SP  - 147
EP  - 158
PB  - Univ. of Umeå
CY  - Umeå
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Technically Optimal Inspection Policy with Arithmetical Adaption
JF  - IMA Journal of Management Mathematics. 14 (2003), H. 4
Y1  - 2003
SN  - 1471-678X
N1  - weitere ISSN 1471-6798 (E)
SP  - 357
EP  - 371
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economically Optimal Inspection Policy with Geometrical Adaption
JF  - Journal of Applied Statistics. 30 (2003), H. 5
Y1  - 2003
SN  - 0266-4763
N1  - weitere ISSN 1360-0532 (E)
SP  - 555
EP  - 569
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economically Optimal Inspection Policy with Arithmetical Adaption
JF  - Applied stochastic models and data analysis / [10th International Symposium on Applied Stochastic Models and Analysis, June 12-15 2001, Université Technologique de Compiègne] ; editors Gérard Govaert, Jacques Janssen, Nikolaos Limnios.
Y1  - 2001
N1  - ASDMA 2001
SP  - 1010
EP  - 1015
PB  - Université Technologique de Compiègne
CY  - Compiègne
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economically Optimal Adaptive Inspection Policies
JF  - Economic Quality Control. 15 (2000), H. 1/2
Y1  - 2000
SN  - 0940-5151
N1  - Printausgabe vorhanden: 43 Z 711
SP  - 55
EP  - 77
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Economic Machine Adjustment in the Case of Product Screening .E.v.Collani, Ch. Weigand
JF  - Statistical Papers. 33 (1992)
Y1  - 1992
SP  - 171
EP  - 184
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - On the Effects of SPC on Production Time
JF  - Economic Quality Control. 8 (1993)
Y1  - 1993
SN  - 0940-5151
SP  - 23
EP  - 61
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - A new Approach for Optimal Control of a Production process
JF  - Economic Quality Control. 7 (1992)
Y1  - 1992
SN  - 0940-5151
SP  - 225
EP  - 251
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Defining Precisions for Reliable Measurement and Estimation Procedures
JF  - Economic Quality Control. 24 (2009), H. 1
Y1  - 2009
SN  - 0940-5151
SP  - 5
EP  - 33
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Weigand, Christoph
T1  - Statistical Tests Based on Reliability and Precision
JF  - Economic Quality Control : EQC ; international journal for quality and reliability
N2  - The construction of a statistical test is investigated which is based only on “reliability” and “precision” as quality criteria. The reliability of a statistical test is quantifiedin a straightforward way by the probability that the decision of the test is correct.  However, the quantification of the precision of a statistical test is not at all evident.  Thereforethe paper presents and discusses several approaches.  Moreover the distinction of “nullhypothesis” and “alternative hypothesis” is not necessary any longer.
Y1  - 2012
U6  - http://dx.doi.org/10.1515/eqc-2012-0002
SN  - 1869-6147
VL  - 27
IS  - 1
SP  - 43
EP  - 64
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Wegner, Lena
A1  - von Arx, Georg
A1  - Sass-Klaassen, Ute G. W.
A1  - Eilmann, Britta
T1  - ROXAS – an efficient and accurate tool to detect vessels in diffuse-porous species
JF  - IAWA Journal / International Association of Wood Anatomists
Y1  - 2013
U6  - http://dx.doi.org/10.1163/22941932-00000034
SN  - 0928-1541 (Print)
SN  - 2294-1932 (Online)
VL  - 34
IS  - 4
SP  - 425
EP  - 432
PB  - Brill
CY  - Leiden
ER  - 
TY  - JOUR
A1  - Wegmann, Kilian
A1  - Hackl, Michael
A1  - Staat, Manfred
A1  - Mayer, Katharina
A1  - Müller, Lars-Peter
T1  - Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results
JF  - Knee surgery, sports traumatology, arthroscopy
N2  - While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates.
Y1  - 2016
U6  - http://dx.doi.org/10.1007/s00167-016-4079-0
SN  - 0942-2056
VL  - Volume 24
IS  - Supplement 1
SP  - 58
EP  - 59
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Weemstra, Monique
A1  - Eilmann, Britta
A1  - Sass-Klaassen, Ute G. W.
A1  - Sterck, Frank J.
T1  - Summer droughts limit tree growth across 10 temperate species on a productive forest site
JF  - Forest Ecology and Management
Y1  - 2013
U6  - http://dx.doi.org/doi:10.1016/j.foreco.2013.06.007
SN  - 0378-1127 (Print)
SN  - 1872-7042  (Online)
VL  - 2013
IS  - 306
SP  - 142
EP  - 149
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wedrowski, M.
A1  - Bruyndonckx, P.
A1  - Tavernier, S.
A1  - Zhi, L.
A1  - Dang, J.
A1  - Mendes, P. R.
A1  - Perez, J. M.
A1  - Ziemons, Karl
T1  - Robustness of neural networks algorithm for gamma detection in monolithic block detector, positron emission tomography
JF  - 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)
N2  - The monolithic scintillator block approach for gamma detection in the Positron Emission Tomography (PET) avoids estimating Depth of Interaction (DOI), reduces dead zones in detector and diminishes costs of detector production. Neural Networks (NN) are very efficient to determine the entrance point of a gamma incident on a scintillator block. This paper presents results on the robustness of the spatial resolution as a function of the random fraction in the data, temperature and HV fluctuations. This is important when implementing the method in a real scanner. Measurements were done with two Hamamatsu S8550 APD arrays, glued on a 20 × 20 × 10 mm3 monolithic LSO crystal block.
Y1  - 2009
SN  - 1082-3654
SP  - 2625
EP  - 2628
ER  - 
TY  - JOUR
A1  - Weckesser, Matthias
A1  - Hufnagel, Andreas
A1  - Ziemons, Karl
A1  - Grießmeier, Martin
A1  - Sonnenberg, Frank
A1  - Hackländer, Thomas
A1  - Langen, Karl-J.
A1  - Holschbach, Markus
A1  - Elger, Christian E.
A1  - Müller-Gärtner, Hans-W.
T1  - Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy
JF  - European Journal of Nuclear Medicine
N2  - Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration.
Y1  - 1997
SN  - 1619-7089
VL  - 24
IS  - 9
SP  - 1156
EP  - 1161
ER  - 
TY  - JOUR
A1  - Weckesser, Martin
A1  - Grießmeier, Martin
A1  - Schmidt, Daniela
A1  - Sonnenberg, Frank
A1  - Ziemons, Karl
A1  - Kemna, Lars
A1  - Holschbach, Marcus
A1  - Langen, Karl-J.
A1  - Müller-Gärtner, Hans-W.
T1  - Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent
JF  - European Journal of Nuclear Medicine
N2  - Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%–25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment.
Y1  - 1998
SN  - 1619-7089
VL  - 25
IS  - 2
SP  - 150
EP  - 156
ER  - 
TY  - CHAP
A1  - Weber, Tobias
A1  - Tellis, Jane J.
A1  - Duhovic, Miro
T1  - Characterization of tool-part-interaction an interlaminar friction for manufacturing process simulation
T2  - ECCM 17, 17th European Conference on Composite Materials, München, DE, Jun 26-30, 2016
Y1  - 2016
SN  - 978-3-00-053387-7
SP  - 1
EP  - 7
ER  - 
TY  - JOUR
A1  - Weber, Tobias
A1  - Ruff-Stahl, Hans-Joachim K.
T1  - Advances in Composite Manufacturing of Helicopter Parts
JF  - International Journal of Aviation, Aeronautics, and Aerospace
Y1  - 2017
U6  - http://dx.doi.org/10.15394/ijaaa.2017.1153
SN  - 2374-6793
VL  - 4
IS  - 1
ER  - 
TY  - CHAP
A1  - Weber, Tobias
A1  - Englhard, Markus
A1  - Hailer, Benjamin
A1  - Arent, Jan-Christoph
T1  - Manufacturing Process Simulation for the Prediction of Tool-Part-Interaction and Ply Wrinkling
T2  - Proceedings of SAMPE Europe Conference 2019, Nantes, France
Y1  - 2019
SP  - 1
EP  - 10
ER  - 
TY  - CHAP
A1  - Weber, Tobias
A1  - Englhard, Markus
A1  - Hailer, Benjamin
A1  - Arent, Jan-Christoph
T1  - Manufacturing Process Simulation for the Prediction of Tool-Part-Interaction and Ply Wrinkling
T2  - Proceedings of SAMPE Europe Conference, Amiens , France
Y1  - 2015
SP  - 1
EP  - 10
ER  - 
TY  - JOUR
A1  - Weber, Tobias
A1  - Englhard, Markus
A1  - Arent, Jan-Christoph
A1  - Hausmann, Joachim
T1  - An experimental characterization of wrinkling generated during prepreg autoclave manufacturing using caul plates
JF  - Journal of Composite Materials
Y1  - 2019
U6  - http://dx.doi.org/10.1177/0021998319846556
SN  - 1530-793X
VL  - 53
IS  - 26-27
SP  - 3757
EP  - 3773
ER  - 
TY  - JOUR
A1  - Weber, Tobias
A1  - Arent, Jan-Christoph
A1  - Steffen, Lucas
A1  - Balvers, Johannes M.
A1  - Duhovic, Miro
T1  - Thermal optimization of composite autoclave molds using the shift factor approach for boundary condition estimation
JF  - Journal of Composite Materials
Y1  - 2017
U6  - http://dx.doi.org/10.1177/0021998317699868
SN  - 1530-793X
VL  - 51
IS  - 12
SP  - 1753
EP  - 1767
PB  - Sage
CY  - London
ER  - 
TY  - JOUR
A1  - Weber, Tobias
A1  - Arent, Jan-Christoph
A1  - Münch, Lukas
A1  - Duhovic, Miro
A1  - Balvers, Johannes M.
T1  - A fast method for the generation of boundary conditions for thermal autoclave simulation
JF  - Composites Part A
N2  - Manufacturing process simulation enables the evaluation and improvement of autoclave mold concepts early in the design phase. To achieve a high part quality at low cycle times, the thermal behavior of the autoclave mold can be investigated by means of simulations. Most challenging for such a simulation is the generation of necessary boundary conditions. Heat-up and temperature distribution in an autoclave mold are governed by flow phenomena, tooling material and shape, position within the autoclave, and the chosen autoclave cycle. This paper identifies and summarizes the most important factors influencing mold heat-up and how they can be introduced into a thermal simulation. Thermal measurements are used to quantify the impact of the various parameters. Finally, the gained knowledge is applied to develop a semi-empirical approach for boundary condition estimation that enables a simple and fast thermal simulation of the autoclave curing process with reasonably high accuracy for tooling optimization.
Y1  - 2016
U6  - http://dx.doi.org/10.1016/j.compositesa.2016.05.036
SN  - 1359-835X
VL  - 88
SP  - 216
EP  - 225
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - CHAP
A1  - Weber, Tobias
T1  - Manufacturing Process Simulation for Tooling Optimization: Reduction of Quality Issues During Autoclave Manufacturing of Composite Parts
T2  - Proceedings of SAMPE Europe Conference 2015, Amiens, France
Y1  - 2015
SP  - 1
EP  - 8
ER  - 
TY  - CHAP
A1  - Weber, S.
A1  - Terstegge, Andreas
A1  - Halling, H.
A1  - Herzog, H.
A1  - Reinartz, R.
A1  - Reinhart, P.
A1  - Rongen, F.
A1  - Müller-Gärtner, H.-W.
T1  - The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity
T2  - Conference record / 1995 IEEE Nuclear Science Symposium and Medical Imaging, October 21 - 28, 1995, San Francisco ; vol. 2
Y1  - 1995
SN  - 078033180X ; 0780331818 ; 0780331826
SP  - 1002
EP  - 1005
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - CHAP
A1  - Weber, S.
A1  - Terstegge, Andreas
A1  - Engels, R.
A1  - Herzog, H.
A1  - Reinartz, R.
A1  - Reinhart, P.
A1  - Rongen, F.
A1  - Müller-Gärtner, H. W.
A1  - Halling, H.
T1  - The KFA TierPET: performance characteristics and measurements
T2  - Conference record / 1996 IEEE Nuclear Science Symposium [and Medical Imaging], November 2 - 9, 1996, Anaheim, California ; vol. 2
Y1  - 1996
SN  - 0-7803-3534-1
SN  - 1082-3654
SP  - 1117
EP  - 1119
PB  - IEEE
CY  - Piscataway, NJ
ER  - 
TY  - CHAP
A1  - Weber, Ingo
A1  - Markovic, Ivan
A1  - Drumm, Christian
T1  - A conceptual framework for composition in business process management
T2  - Business Information Systems : 10th International Conference, BIS 2007, Poznan, Poland, April 25-27, 2007. Proceedings
Y1  - 2007
SN  - 978-3-540-72035-5
U6  - http://dx.doi.org/10.1007/978-3-540-72035-5_5
SP  - 54
EP  - 66
PB  - Springer
CY  - Berlin, Heidelberg
ER  - 
TY  - CHAP
A1  - Weber, Hans-Joachim
A1  - Porschen, W.
A1  - Dietzel, F.
A1  - [u.a.], 
ED  - Streffer, Christian
T1  - In vivo analysis of the influence of combined hyperthermia and gamma irradiation on euoxic and hypoxic tumor cells
T2  - Cancer therapy by hyperthermia and radiation : [proceedings of the 2. International Symposium on Cancer Therapy by Hyperthermia and Radiation, Essen, 2.-4.6.1977]
Y1  - 1978
SN  - 0-8067-1701-7
SN  - 3-541-71701-7
SP  - 276
EP  - 277
PB  - Urban and Schwarzenberg
CY  - Baltimore ; Munich [u.a.]
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
A1  - Ramakrishna, S.
T1  - PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation / X. Mo, H.-J. Weber, S. Ramakrishna
JF  - The International journal of artificial organs. 29 (2006), H. 8
Y1  - 2006
SP  - 790
EP  - 799
PB  - -
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
A1  - Chen, Zonggang
T1  - Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering / Mo Xiumei, Chen Zonggang, Hans J. Weber
JF  - Frontiers of materials science in China. 1 (2007), H. 1
Y1  - 2007
SN  - 1673-7377
SP  - 20
EP  - 23
PB  - -
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Mo, Xiumei
T1  - Electrospinning P(LLA-CL) nanofiber: a tubular scaffold fabrication with circumferential alignment / Xiumei Mo, Hans-Joachim Weber
JF  - Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder
Y1  - 2004
N1  - Österreichische Polymertage <6, 2003, Wien>. - (Macromolecular symposia ; 217,1)
SP  - 413
EP  - 416
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Weber, Hans-Joachim
A1  - Laco, Filip
A1  - Kun, Ma
A1  - Ramakrishna, S.
T1  - The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture / Laco, Filip ; Kun, Ma ; Weber, Hans Joachim ; Ramakrishna, S. ; Chan, Casey K.
JF  - Journal of Dermatological Science. 55 (2009), H. 3
Y1  - 2009
SN  - 0923-1811
SP  - 150
EP  - 160
ER  -