TY - JOUR A1 - Sildatke, Michael A1 - Karwanni, Hendrik A1 - Kraft, Bodo A1 - Zündorf, Albert T1 - A distributed microservice architecture pattern for the automated generation of information extraction pipelines JF - SN Computer Science N2 - Companies often build their businesses based on product information and therefore try to automate the process of information extraction (IE). Since the information source is usually heterogeneous and non-standardized, classic extract, transform, load techniques reach their limits. Hence, companies must implement the newest findings from research to tackle the challenges of process automation. They require a flexible and robust system that is extendable and ensures the optimal processing of the different document types. This paper provides a distributed microservice architecture pattern that enables the automated generation of IE pipelines. Since their optimal design is individual for each input document, the system ensures the ad-hoc generation of pipelines depending on specific document characteristics at runtime. Furthermore, it introduces the automated quality determination of each available pipeline and controls the integration of new microservices based on their impact on the business value. The introduced system enables fast prototyping of the newest approaches from research and supports companies in automating their IE processes. Based on the automated quality determination, it ensures that the generated pipelines always meet defined business requirements when they come into productive use. KW - Architectural design KW - Model-driven software engineering KW - Software and systems modeling KW - Enterprise information systems KW - Information extraction Y1 - 2023 U6 - http://dx.doi.org/10.1007/s42979-023-02256-4 SN - 2661-8907 N1 - Corresponding authors: Michael Sildatke, Hendrik Karwanni IS - 4, Article number: 833 PB - Springer Singapore CY - Singapore ER - TY - CHAP A1 - Sildatke, Michael A1 - Karwanni, Hendrik A1 - Kraft, Bodo A1 - Schmidts, Oliver A1 - Zündorf, Albert T1 - Automated Software Quality Monitoring in Research Collaboration Projects T2 - ICSEW'20: Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops Y1 - 2020 U6 - http://dx.doi.org/10.1145/3387940.3391478 SP - 603 EP - 610 ER - TY - JOUR A1 - Siepmann, Thomas A1 - Schuh, G. A1 - Levering, V. T1 - PROPLAN / Schuh, G.; Siepmann, Th.; Levering, V. JF - Handbook on architectures of information systems : with 24 tables / Peter Bernus ... (ed.) Y1 - 1998 SN - 3-540-64453-9 N1 - International handbooks on information systems ; 1 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Siepmann, Thomas A1 - Rupietta, D. T1 - Closer to the customer with computerized product support JF - Technische Mitteilungen Krupp (1993) Y1 - 1993 CY - Essen ER - TY - BOOK A1 - Siepmann, Thomas T1 - Modeller for Value Systems Y1 - 1997 PB - Erasmus Universiteit Rotterdam CY - Rotterdam ER - TY - JOUR A1 - Siepmann, Thomas T1 - Exploitation Plan of the TELEflow Project Y1 - 1999 N1 - 4th Framework Programme Report CY - Brussels ER - TY - CHAP A1 - Siekmann, Thomas A1 - Müller, Karsten T1 - Adaptive potential of the stormwater management in urban areas faced by the climate change T2 - 12th International Conference on Urban Drainage, Porto Alegre/Brazil, 11-16 September 2011 Y1 - 2011 ER - TY - JOUR A1 - Sieker, Tim A1 - Neuner, Andreas A1 - Dimitrova, Darina A1 - Tippkötter, Nils A1 - Muffler, Kai A1 - Bart, Hans-Jörg A1 - Heinzle, Elmar A1 - Ulber, Roland T1 - Ethanol production from grass silage by simultaneous pretreatment, saccharification and fermentation: First steps in the process development JF - Engineering in Life Sciences N2 - Grass silage provides a great potential as renewable feedstock. Two fractions of the grass silage, a press juice and the fiber fraction, were evaluated for their possible use for bioethanol production. Direct production of ethanol from press juice is not possible due to high concentrations of organic acids. For the fiber fraction, alkaline peroxide or enzymatic pretreatment was used, which removes the phenolic acids in the cell wall. In this study, we demonstrate the possibility to integrate the enzymatic pretreatment with a simultaneous saccharification and fermentation to achieve ethanol production from grass silage in a one-process step. Achieved yields were about 53 g ethanol per kg silage with the alkaline peroxide pretreatment and 91 g/kg with the enzymatic pretreatment at concentrations of 8.5 and 14.6 g/L, respectively. Furthermore, it was shown that additional supplementation of the fermentation medium with vitamins, trace elements and nutrient salts is not necessary when the press juice is directly used in the fermentation step. Y1 - 2011 U6 - http://dx.doi.org/10.1002/elsc.201000160 N1 - Special Issue "Bioprocess‐oriented plant design" VL - 11 IS - 4 SP - 436 EP - 442 PB - Wiley CY - Weinheim ER - TY - CHAP A1 - Siegert, Petra A1 - Pohl, Martina A1 - Kneen, Malea M. A1 - Pogozheva, Irina D. A1 - Kenyon, George L. A1 - McLeish, Michael J. T1 - Exploring the substrate specificity of benzoylformate decarboxylase, pyruvate decarboxylase, and benzaldehyde lyase T2 - Thiamine : catalytic mechanisms in normal and disease states / ed. by Frank Jordan ... Y1 - 2004 SN - 0-8247-4062-9 SP - 275 EP - 290 PB - Dekker CY - New York, NY ER - TY - JOUR A1 - Siegert, Petra A1 - McLeish, Michael J. A1 - Baumann, Martin A1 - Iding, Hans A1 - Kneen, Malea M. A1 - Kenyon, George L. A1 - Pohl, Martina T1 - Exchanging the substrate specificities of pyruvate decarboxylase from Zymomonas mobilis and benzoylformate decarboxylase from Pseudomonas putida JF - Protein engineering, design, and selection : peds Y1 - 2005 SN - 1460-213X (E-Journal); 1741-0134 (E-Journal); 0269-2139 (Print); 1741-0126 (Print) VL - Vol. 18 IS - Iss. 7 SP - 345 EP - 357 ER - TY - CHAP A1 - Siegert, Petra A1 - Iding, Hans A1 - Baumann, Martin A1 - McLeish, Michael J. A1 - Kenyon, George L. A1 - Pohl, Martina T1 - Broadening of the substrate spectra of two ThDP-dependent decarboxylases using site-directed-mutagenesis T2 - Proceedings of the 4th International Congress on Biochemical Engineering : 17 and 18 February 2000, Stuttgart Y1 - 2000 SN - 3-8167-5570-4 SP - 38 EP - 42 ER - TY - CHAP A1 - Siebigteroth, Ines A1 - Kraft, Bodo A1 - Schmidts, Oliver A1 - Zündorf, Albert T1 - A Study on Improving Corpus Creation by Pair Annotation T2 - Proceedings of the Poster Session of the 2nd Conference on Language, Data and Knowledge (LDK-PS 2019) Y1 - 2019 SN - 1613-0073 SP - 40 EP - 44 ER - TY - CHAP A1 - Sherelkhan, Dinara A1 - Alibekova, Alina ED - Digel, Ilya ED - Staat, Manfred ED - Trzewik, Jürgen ED - Sielemann, Stefanie ED - Erni, Daniel ED - Zylka, Waldemar T1 - EEM spectroscopy characterization of humic substances of biomedical importance T2 - 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen N2 - Humic substances possess distinctive chemical features enabling their use in many advanced applications, including biomedical fields. No chemicals in nature have the same combination of specific chemical and biological properties as humic substances. Traditional medicine and modern research have demonstrated that humic substances from different sources possess immunomodulatory and anti-inflammatory properties, which makes them suitable for the prevention and treatment of chronic dermatoses, allergic rhinitis, atopic dermatitis, and other conditions characterized by inflammatory and allergic responses [1-4]. The use of humic compounds as agentswith antifungal and antiviral properties shows great potential [5-7]. Y1 - 2024 SN - 978-3-940402-65-3 U6 - http://dx.doi.org/10.17185/duepublico/81475 SP - 31 EP - 32 PB - Universität Duisburg-Essen CY - Duisburg ER - TY - CHAP A1 - Shahidi, Parham A1 - Pfaff, Raphael A1 - Enning, Manfred T1 - The connected wagon - a concept for the integration of vehicle side sensors and actors with cyber physical representation for condition based maintenance T2 - First International Conference on Rail Transportation Y1 - 2017 N1 - 2017 ICRT; International Conference on Rail Transportation <1, 2017, Chengdu, China> SP - 1 EP - 8 ER - TY - JOUR A1 - Seynnes, O. R. A1 - Bojsen-Moller, J. A1 - Albracht, Kirsten A1 - Arndt, A. A1 - Cronin, N. J. A1 - Finni, T. A1 - Magnusson, S. P. T1 - Ultrasound-based testing of tendon mechanical properties: a critical evaluation JF - Journal of Applied Physiology Y1 - 2015 U6 - http://dx.doi.org/10.1152/japplphysiol.00849.2014 SN - 8750-7587 VL - 118 IS - 2 SP - 133 EP - 141 ER - TY - CHAP A1 - Serror, Martin A1 - Henze, Martin A1 - Hack, Sacha A1 - Schuba, Marko A1 - Wehrle, Klaus T1 - Towards in-network security for smart homes T2 - 13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018 Y1 - 2018 SN - 978-145036448-5 U6 - http://dx.doi.org/10.1145/3230833.3232802 SP - Article numer 3232802 ER - TY - JOUR A1 - Serror, Martin A1 - Hack, Sacha A1 - Henze, Martin A1 - Schuba, Marko A1 - Wehrle, Klaus T1 - Challenges and Opportunities in Securing the Industrial Internet of Things JF - IEEE Transactions on Industrial Informatics Y1 - 2021 U6 - http://dx.doi.org/10.1109/TII.2020.3023507 SN - 1941-0050 VL - 17 IS - 5 SP - 2985 EP - 2996 PB - IEEE CY - New York ER - TY - JOUR A1 - Selmer, Thorsten A1 - Yu, Lihua A1 - Blaser, Martin A1 - Andrei, Paula I. T1 - 4-Hydroxyphenylacetate decarboxylases: properties of a novel subclass of glycyl radical enzyme systems / Yu, L. ; Blaser, M. ; Andrei, PI. ; Pierik, AJ. Selmer, T. JF - Biochemistry. 31 (2006), H. 45 Y1 - 2006 N1 - PMID: 16878993 SP - 9584 EP - 9592 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Willanzheimer, Angela A1 - Hetzel, Marc T1 - Propionate CoA-transferase from Clostridium propionicum. Cloning of the gene and identification of glutamate 324 at the active site JF - European Journal of Biochemistry. 269 (2002), H. 1 Y1 - 2002 SN - 0014-2956 SP - 372 EP - 380 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Thamer, Wiebke A1 - Cirpus, Irina A1 - Hans, Marcus T1 - A two [4Fe-4S]-cluster-containing ferredoxin as an alternative electron donor for 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans / Thamer, Wiebke ; Cirpus, Irina ; Hans, Marcus ; Pierik, Antonio, J. ; Selmer, Thorsten ; Bill, Eckhard ; JF - Archives of Microbiology. 179 (2003), H. 3 Y1 - 2003 SN - 1432-072X SP - 197 EP - 204 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Sommerlade, Hans-Jörg A1 - Ingendoh, Arnd A1 - Gieselmann, Volkmar T1 - Glycosylation and phosphorylation of arylsulfatase A / Sommerlade, Hans-Jörg. ; Selmer, Thomas. ; Ingendoh, Arnd ; Gieselmann, Volkmar ; Figura, Kurt von ; Neifer, Klaus ; Schmidt, Bernhard JF - Journal of Biological Chemistry. 269 (1994), H. 33 Y1 - 1994 SN - 1083-351X SP - 20977 EP - 20981 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Scott, Richard A1 - Näser, Ulrike A1 - Friedrich, Peter T1 - Stereochemistry of hydrogen removal from the 'unactivated' C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase / Scott, R. ; Näser, U. ; Friedrich, P. ; Selmer, T. ; Buckel, W. ; Golding, BT. JF - Chemical Communications : ChemCom (2004) Y1 - 2004 SN - 1364-548X SP - 1210 EP - 1211 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Schmidt, Bernhard A1 - Ingendoh, Arnd A1 - Figura, Kurt von T1 - A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency / Schmidt, Bernhard ; Selmer, Thorsten ; Ingendoh, Arnd ; Figurat, Kurt von JF - Cell. 82 (1995), H. 2 Y1 - 1995 SN - 0092-8674 SP - 271 EP - 278 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Recksiek, Michael A1 - Dierks, Thomas A1 - Schmidt, Bernhard T1 - Sulfatases, Trapping of the Sulfated Enzyme Intermediate by Substituting the Active Site Formylglycine / Recksiek, Michael ; Selmer, Thorsten ; Dierks, Thomas ; Schmidt, Bernhard ; Figura, Kurt von JF - Journal of Biological Chemistry. 273 (1998), H. 11 Y1 - 1998 SN - 1083-351X SP - 6096 EP - 6103 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Pinkenburg, Olaf T1 - Method of cloning at least one nucleic acid molecule of interest using type IIS restriction endonucleases, and corresponding cloning vectors, kits and system using type IIS restriction endonucleases / Selmer, Thorsten ; Pinkenburg, Olaf Y1 - 2008 N1 - Patent No. WO 2008095927 A1 Aug 14, 2008 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Pierik, Antonio J. A1 - Heider, Johann T1 - New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria JF - Biological Chemistry. 386 (2005), H. 10 Y1 - 2005 SN - 1431-6730 SP - 981 EP - 988 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Netz, Daili Jacqueline Aguilar A1 - Pohl, Regula A1 - Beck-Sickinger, Annette G. T1 - Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus / Netz, Daili Jacqueline Aguilar ; Pohl, Regula ; Beck-Sickinger, Annette G. ; Selmer, Thorsten ; Pierik, Antonio J. ; Carmo de Frei JF - Journal of Molecular Biology. 319 (2002), H. 3 Y1 - 2002 SN - 0022-2836 SP - 745 EP - 756 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Miech, Claudia A1 - Dierks, Thomas A1 - Figura, Kurt von T1 - Arylsulfatase from Klebsiella pneumoniae Carries a Formylglycine Generated from a Serine / Miech, Claudia ; Dierks, Thomas ; Selmer, Thorsten ; Figura, Kurt von ; Schmidt, Bernd JF - Journal of Biological Chemistry. 273 (1998), H. 9 Y1 - 1998 SN - 1083-351X SP - 4835 EP - 4837 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Lukatela, G. A1 - Krauss, N. A1 - Theis, K. T1 - Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis / Lukatela, G. ; Krauss, N. ; Theis, K. ; Selmer, T. ; Gieselmann, V. ; Figura, K. von ; Saenger, JF - Biochemistry. 37 (1998), H. 11 Y1 - 1998 SP - 3654 EP - 3664 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Kim, Jihoe A1 - Darley, Daniel A1 - Buckel, Wolfgang T1 - Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile / Kim, J. ; Darley, D. ; Selmer, T. ; Buckel, W. JF - Applied and Environmental Microbiology. 72 (2006), H. 9 Y1 - 2006 SN - 0099-2240 N1 - PMID: 16957230 SP - 6062 EP - 6069 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Kahnt, Jörg A1 - Goubeaud, Marcel A1 - Shima, Seigo T1 - The biosynthesis of methylated amino acids in the active site region of methyl-coenzyme M reductase / Selmer, Thorsten ; Kahnt, Jörg ; Goubeaud, Marcel ; Shima, Seigo ; Grabarse, Wolfgang ; Ermler, Ulrich ; Thauer, Rudolf K. JF - Journal of Biological Chemistry. 275 (2000), H. 6 Y1 - 2000 SN - 1083-351X SP - 3775 EP - 3760 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Jennemann, Richard A1 - Bauer, Bernhard L. A1 - Bertalanffy, Helmut T1 - Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus / Jennemann, Richard ; Bauer, Bernhard, L. ; Bertalanffy, Helmut ; Geyer, Rudolf ; Gschwind, Ruth, M. ; Selmer, Thorsten ; Wiegandt, Herbert JF - European Journal of Biochemistry. 259 (1999), H. 1-2 Y1 - 1999 SN - 0014-2956 SP - 331 EP - 338 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Jennemann, Richard A1 - Bauer, Bernhard L. A1 - Bertalanffy, Helmut T1 - Basidiolipids from Agaricus are novel immune adjuvants / Jennemann, R. ; Bauer, BL. ; Bertalanffy, H. ; Selmer, T. ; Wiegandt, H. JF - Immunobiology. 200 (1999), H. 2 Y1 - 1999 SN - 0171-2985 N1 - PMID: 10416134 SP - 277 EP - 289 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Hetzel, Marc A1 - Brock, Matthias A1 - Pierik, Antonio J. T1 - Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein / Hetzel, Marc ; Brock, Matthias ; Selmer, Thorsten, Pierik, Antonio J. ; Golding, Bernard T. ; Buckel, Wolfgang JF - European Journal of Biochemistry. 270 (2003), H. 5 Y1 - 2003 SN - 0014-2956 SP - 902 EP - 910 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Hermann, Gloria A1 - Jessen, Holly A1 - Gokarn, Ravi R. T1 - Two beta-alanyl-CoA:ammonia lyases in Clostridium propionicum / Herrmann , G. ; Selmer, T. ; Jessen, HJ. ; Gokarn, RR. ; Selifonova, O. ; Gort , SJ. ; , Buckel, W. JF - The FEBS Journal. 272 (2005), H. 3 Y1 - 2005 SN - 1742-464X SP - 813 EP - 821 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Hallmann, Armin A1 - Schmidt, Bernhard A1 - Sumper, Manfred T1 - The Evolutionary Conservation of a Novel Protein Modification, the Conversion of Cysteine to Serinesemialdehyde in Arylsulfatase from Volvox carteri / Selmer, Thorsten ; Hallmann, Armin ; Schmidt, Bernhard ; Sumper, Manfred ; Figura, Kurt von JF - European Journal of Biochemistry. 238 (1996), H. 2 Y1 - 1996 SN - 0014-2956 SP - 341 EP - 345 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Figura, Kurt von A1 - Schmidt, Bernhard A1 - Dierks, T. T1 - A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease / Figura, Kurt von ; Schmidt, Bernhard ; Selmer, Thorsten ; Dierks, Thomas JF - Bioessays. 20 (1998), H. 6 Y1 - 1998 SN - 1521-1878 SP - 505 EP - 510 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Darley, Dan J. A1 - Clegg, William A1 - Harrington, Ross W. T1 - Stereocontrolled Synthesis of (2R,3S)-2-Methylisocitrate, a Central Intermediate in the Methylcitrate Cycle / Darley, Dan J. ; Selmer, Thorsten ; Clegg, William ; Harrington, Ross W. ; Buckel, Wolfgang ; Golding, Bernardt JF - Helvetica chimica acta. 86 (2003), H. 12 Y1 - 2003 SN - 1522-2675 SP - 3991 EP - 3999 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Buckel, Wolfgang T1 - Oxygen Exchange between Acetate and the Catalytic Glutamate Residue in Glutaconate CoA-transferase from Acidaminococcus fermentans. IMPLICATIONS FOR THE MECHANISM OF CoA-ESTER HYDROLYSIS JF - Journal of Biological Chemistry. 274 (1999), H. 30 Y1 - 1999 SN - 1083-351X SP - 20772 EP - 20778 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Brüser, Thomas A1 - Dahl, Christiane T1 - ADP Sulfurylase" from Thiobacillus denitrificans Is an Adenylylsulfate:Phosphate Adenylyltransferase and Belongs to a New Family of Nucleotidyltransferases / Brüser, Thomas ; Selmer, Thorsten ; Dahl, Christiane JF - Journal of Biological Chemistry. 275 (2000), H. 3 Y1 - 2000 SN - 1083-351X SP - 1691 EP - 1690 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Andrei, Paula I. A1 - Pierik, Antonio J. A1 - Zauner, Stefan T1 - Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity / Andrei, PI. ; Pierik, AJ. ; Zauner , S. ; Andrei-Selmer, LC. ; Selmer, T. JF - European Journal of Biochemistry. 271 (2004), H. 11 Y1 - 2004 SN - 0014-2956 SP - 2225 EP - 2230 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Andrei, Paula I. T1 - p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol JF - European Journal of Biochemistry. 268 (2001), H. 5 Y1 - 2001 SN - 0014-2956 SP - 1363 EP - 1372 ER - TY - JOUR A1 - Selmer, Thorsten A1 - Achebach, Stephanie A1 - Unden, Gottfried T1 - Properties and significance of apoFNR as a second form of air-inactivated [4Fe-4S]·FNR of Escherichia coli / Achebach, S. ; Selmer, T. ; Unden, G. JF - The FEBS Journal. 272 (2005), H. 16 Y1 - 2005 SN - 1742-464X SP - 4260 EP - 4269 ER - TY - JOUR A1 - Seiler, Friedrich A1 - Pichler, Alexander A1 - Pfaff, Raphael A1 - Srulijes, Julio T1 - Novel processing tools for automated doppler picture velocimetry (DPV) evaluation JF - Journal of visualization Y1 - 2009 SN - 1343-8875 VL - Vol. 12 IS - Iss. 4 SP - 323 EP - 337 ER - TY - CHAP A1 - Seiler, Friedrich A1 - Pichler, Alexander A1 - Pfaff, Raphael A1 - George, Alfred A1 - Srulijes, Julio T1 - Improved Doppler picture velocimetry and new automated processing T2 - 14th International Symposium on Applications of Laser Techniques to Fluid Mechanics : Lisbon, Portugal, 7 - 10 July 2008 Y1 - 2008 SP - 1 EP - 12 ER - TY - JOUR A1 - Seifarth, Volker A1 - Schehl, D. A1 - Linder, Peter A1 - Gossmann, Matthias A1 - Digel, Ilya A1 - Artmann, Gerhard A1 - Porst, Dariusz A1 - Preiß, C. A1 - Kayser, Peter A1 - Pack, O. A1 - Temiz Artmann, Aysegül T1 - Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds N2 - The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days. KW - Tissue Engineering KW - Bioreaktor KW - Organkultur KW - Harnleiter Y1 - 2011 ER - TY - JOUR A1 - Seifarth, Volker A1 - Grosse, Joachim O. A1 - Grossmann, Matthias A1 - Janke, Heinz Peter A1 - Arndt, Patrick A1 - Koch, Sabine A1 - Epple, Matthias A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation JF - Journal of Biomaterials Applications Y1 - 2017 U6 - http://dx.doi.org/10.1177/0885328217723178 SN - 1530-8022 VL - 32 IS - 3 SP - 321 EP - 330 PB - Sage CY - London ER - TY - JOUR A1 - Seifarth, Volker A1 - Goßmann, Matthias A1 - Grosse, J. O. A1 - Becker, C. A1 - Heschel, I. A1 - Artmann, Gerhard A1 - Temiz Artmann, Aysegül T1 - Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds JF - Urologia Internationalis Y1 - 2015 U6 - http://dx.doi.org/10.1159/000368419 SN - 0042-1138 VL - 2015 IS - 95 SP - 106 EP - 113 PB - Karger CY - Basel ER - TY - THES A1 - Seifarth, Volker T1 - Ureteral tissue engineering : development of a bioreactor system and subsequent characterization of the generated biohybrids Y1 - 2015 N1 - Duisburg, Essen, Universität Duisburg-Essen, Diss., 2015 PB - Universitätsbibliothek Duisburg-Essen CY - Duisburg ; Essen ER - TY - JOUR A1 - Seidova, Seid-Fatima A1 - Kotliar, Konstantin A1 - Foerger, Frauke A1 - Klopfer, Matthias A1 - Lanzl, Ines T1 - Functional retinal changes in Gaucher disease JF - Documenta Ophthalmologica Y1 - 2009 SN - 1573-2622 VL - 118 IS - 2 SP - 151 EP - 154 PB - Springer CY - Berlin ER -